KR100765871B1 - 아토르바스타틴 헤미칼슘의 신규의 결정형, 이의 제조방법 및 다른 형을 제조하는 신규의 방법 - Google Patents

아토르바스타틴 헤미칼슘의 신규의 결정형, 이의 제조방법 및 다른 형을 제조하는 신규의 방법 Download PDF

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KR100765871B1
KR100765871B1 KR1020037007298A KR20037007298A KR100765871B1 KR 100765871 B1 KR100765871 B1 KR 100765871B1 KR 1020037007298 A KR1020037007298 A KR 1020037007298A KR 20037007298 A KR20037007298 A KR 20037007298A KR 100765871 B1 KR100765871 B1 KR 100765871B1
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atorvastatin hemicalcium
atorvastatin
hemicalcium
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KR20030059297A (ko
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아론히메쥬디쓰
리도르-하다스라미
니담발레리
리프쉬츠레비탈
이샤이에티
샘버스키가이
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테바 파마슈티컬 인더스트리즈 리미티드
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/282—Organic compounds, e.g. fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020037007298A 2000-11-30 2001-11-29 아토르바스타틴 헤미칼슘의 신규의 결정형, 이의 제조방법 및 다른 형을 제조하는 신규의 방법 Expired - Fee Related KR100765871B1 (ko)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US25007200P 2000-11-30 2000-11-30
US60/250,072 2000-11-30
US26789701P 2001-02-09 2001-02-09
US60/267,897 2001-02-09
US28187201P 2001-04-05 2001-04-05
US60/281,872 2001-04-05
US31214401P 2001-08-13 2001-08-13
US60/312,144 2001-08-13
US32652901P 2001-10-01 2001-10-01
US60/326,529 2001-10-01
PCT/US2001/044636 WO2002043732A1 (en) 2000-11-30 2001-11-29 Novel crystal forms of atorvastatin hemi-calcium and processes for their preparation as well as novel processes for preparing other forms

Publications (2)

Publication Number Publication Date
KR20030059297A KR20030059297A (ko) 2003-07-07
KR100765871B1 true KR100765871B1 (ko) 2007-10-11

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KR1020037007298A Expired - Fee Related KR100765871B1 (ko) 2000-11-30 2001-11-29 아토르바스타틴 헤미칼슘의 신규의 결정형, 이의 제조방법 및 다른 형을 제조하는 신규의 방법

Country Status (23)

Country Link
US (15) US20020183378A1 (enExample)
EP (5) EP1363621A4 (enExample)
JP (2) JP2004514694A (enExample)
KR (1) KR100765871B1 (enExample)
CN (1) CN1489463A (enExample)
AU (1) AU2002217927A1 (enExample)
BG (1) BG107856A (enExample)
BR (1) BR0115892A (enExample)
CA (3) CA2625277A1 (enExample)
CZ (1) CZ20031766A3 (enExample)
DE (1) DE01998348T1 (enExample)
ES (2) ES2437157T3 (enExample)
HR (2) HRP20030523A2 (enExample)
HU (1) HUP0600538A3 (enExample)
IL (2) IL156055A0 (enExample)
IS (1) IS6829A (enExample)
MX (1) MXPA03004844A (enExample)
NO (1) NO20032425L (enExample)
PL (1) PL363228A1 (enExample)
SK (1) SK8062003A3 (enExample)
TR (1) TR200400815T3 (enExample)
WO (1) WO2002043732A1 (enExample)
YU (1) YU42803A (enExample)

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ITBO20120368A1 (it) 2012-07-06 2014-01-07 Alfa Wassermann Spa Composizioni comprendenti rifaximina e amminoacidi, cristalli di rifaximina derivanti da tali composizioni e loro uso.
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TWI846166B (zh) 2013-11-15 2024-06-21 美商阿克比治療有限公司 {[5-(3-氯苯基)-3-羥基吡啶-2-羰基]胺基}乙酸之固體型式，其組合物及用途
CN103641764B (zh) * 2013-11-25 2015-12-02 北京三泉医药技术有限公司 调节血脂的药物组合物
CN104945300B (zh) * 2015-06-17 2017-05-10 北京嘉林药业股份有限公司 一种ⅰ型阿托伐他汀钙的纯化方法
CN104983690A (zh) * 2015-08-18 2015-10-21 青岛蓝盛洋医药生物科技有限责任公司 一种治疗冠心病的药物阿托伐他汀钙组合物干混悬剂
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