|
US3487890A
(en)
|
1967-04-14 |
1970-01-06 |
Boyles Bros Drilling Co |
Core drilling system
|
|
US3847890A
(en)
|
1971-11-01 |
1974-11-12 |
A Green |
Acidic monosaccharide-substituted proteins
|
|
US4179337A
(en)
|
1973-07-20 |
1979-12-18 |
Davis Frank F |
Non-immunogenic polypeptides
|
|
US4356170A
(en)
|
1981-05-27 |
1982-10-26 |
Canadian Patents & Development Ltd. |
Immunogenic polysaccharide-protein conjugates
|
|
US4757006A
(en)
|
1983-10-28 |
1988-07-12 |
Genetics Institute, Inc. |
Human factor VIII:C gene and recombinant methods for production
|
|
US4970300A
(en)
|
1985-02-01 |
1990-11-13 |
New York University |
Modified factor VIII
|
|
GR860984B
(en)
|
1985-04-17 |
1986-08-18 |
Zymogenetics Inc |
Expression of factor vii and ix activities in mammalian cells
|
|
US5250421A
(en)
|
1986-01-03 |
1993-10-05 |
Genetics Institute, Inc. |
Method for producing factor VIII:C-type proteins
|
|
US5198349A
(en)
|
1986-01-03 |
1993-03-30 |
Genetics Institute, Inc. |
Method for producing factor VIII:C and analogs
|
|
JPH0387173A
(ja)
|
1987-09-10 |
1991-04-11 |
Teijin Ltd |
ヒト活性化天然型ファクター８ｃの製造方法及びそれに用いる形質転換体
|
|
US5153265A
(en)
|
1988-01-20 |
1992-10-06 |
Cetus Corporation |
Conjugation of polymer to colony stimulating factor-1
|
|
US4966999A
(en)
|
1988-06-07 |
1990-10-30 |
Cytogen Corporation |
Radiohalogenated compounds for site specific labeling
|
|
US5122614A
(en)
|
1989-04-19 |
1992-06-16 |
Enzon, Inc. |
Active carbonates of polyalkylene oxides for modification of polypeptides
|
|
SE465222C5
(sv)
|
1989-12-15 |
1998-02-10 |
Pharmacia & Upjohn Ab |
Ett rekombinant, humant faktor VIII-derivat och förfarande för dess framställning
|
|
SE466754B
(sv)
|
1990-09-13 |
1992-03-30 |
Berol Nobel Ab |
Saett att kovalent binda biopolymerer till hydrofila ytor
|
|
EP0513332A4
(en)
|
1990-11-14 |
1993-03-17 |
Cargill, Incorporated |
Conjugates of poly(vinylsaccharide) with proteins for the stabilization of proteins
|
|
JPH06506217A
(ja)
|
1991-03-18 |
1994-07-14 |
エンゾン，インコーポレーテッド |
ポリペプチドまたはグリコポリペプチドとポリマーとのヒドラジン含有結合体
|
|
US5846951A
(en)
|
1991-06-06 |
1998-12-08 |
The School Of Pharmacy, University Of London |
Pharmaceutical compositions
|
|
GB9112212D0
(en)
*
|
1991-06-06 |
1991-07-24 |
Gregoriadis Gregory |
Pharmaceutical compositions
|
|
US6037452A
(en)
|
1992-04-10 |
2000-03-14 |
Alpha Therapeutic Corporation |
Poly(alkylene oxide)-Factor VIII or Factor IX conjugate
|
|
AU5098193A
(en)
|
1992-09-01 |
1994-03-29 |
Berlex Laboratories, Inc. |
Glycolation of glycosylated macromolecules
|
|
HU220194B
(hu)
|
1992-10-02 |
2001-11-28 |
Genetics Institute Inc. |
Koagulációs faktor VIII-at tartalmazó készítmény és eljárás előállítására
|
|
NZ250375A
(en)
|
1992-12-09 |
1995-07-26 |
Ortho Pharma Corp |
Peg hydrazone and peg oxime linkage forming reagents and protein derivatives
|
|
US5298643A
(en)
|
1992-12-22 |
1994-03-29 |
Enzon, Inc. |
Aryl imidate activated polyalkylene oxides
|
|
FR2700268B1
(fr)
|
1993-01-13 |
1995-03-31 |
Lvmh Rech |
Composition cosmétique ou pharmaceutique, notamment dermatologique, contenant un extrait de Vismia.
|
|
WO1994015625A1
(en)
|
1993-01-15 |
1994-07-21 |
Enzon, Inc. |
Factor viii - polymeric conjugates
|
|
AU7097094A
(en)
|
1993-06-01 |
1994-12-20 |
Enzon, Inc. |
Carbohydrate-modified polymer conjugates with erythropoietic activity
|
|
US5621039A
(en)
|
1993-06-08 |
1997-04-15 |
Hallahan; Terrence W. |
Factor IX- polymeric conjugates
|
|
SE504074C2
(sv)
|
1993-07-05 |
1996-11-04 |
Pharmacia Ab |
Proteinberedning för subkutan, intramuskulär eller intradermal administrering
|
|
CA2204726A1
(en)
|
1994-11-09 |
1996-12-27 |
Robin E. Offord |
Functionalized polymers for site-specific attachment
|
|
WO1996040731A1
(en)
|
1995-06-07 |
1996-12-19 |
Mount Sinai School Of Medicine Of The City University Of New York |
Pegylated modified proteins
|
|
SE9503380D0
(sv)
|
1995-09-29 |
1995-09-29 |
Pharmacia Ab |
Protein derivatives
|
|
US5763401A
(en)
|
1996-07-12 |
1998-06-09 |
Bayer Corporation |
Stabilized albumin-free recombinant factor VIII preparation having a low sugar content
|
|
AU5773798A
(en)
|
1997-01-29 |
1998-08-18 |
Polymasc Pharmaceuticals Plc |
Pegylation process
|
|
EP0981548A4
(en)
|
1997-04-30 |
2005-11-23 |
Enzon Inc |
GLYCOSYLATABLE SINGLE CHAIN ANTIGEN-BINDING PROTEINS, MANUFACTURE AND USE THEREOF
|
|
US6183738B1
(en)
|
1997-05-12 |
2001-02-06 |
Phoenix Pharamacologics, Inc. |
Modified arginine deiminase
|
|
WO2001082943A2
(en)
|
2000-05-03 |
2001-11-08 |
Novo Nordisk A/S |
Subcutaneous administration of coagulation factor vii
|
|
AU2051899A
(en)
|
1997-12-03 |
1999-06-16 |
Roche Diagnostics Gmbh |
Method for preparing polypeptides with appropriate glycosilation
|
|
US5985263A
(en)
|
1997-12-19 |
1999-11-16 |
Enzon, Inc. |
Substantially pure histidine-linked protein polymer conjugates
|
|
ATE283034T1
(de)
|
1998-04-27 |
2004-12-15 |
Opperbas Holding Bv |
Pharmazeutische zusammensetzungen enthaltend faktor viii und neutrale liposomen
|
|
JP2002528562A
(ja)
|
1998-08-28 |
2002-09-03 |
グリフォン サイエンシーズ |
長さのばらつきが小さいポリアミド連鎖、その連鎖の製造方法およびその連鎖とタンパク質の複合体
|
|
CN101062419B
(zh)
|
1998-10-16 |
2016-06-29 |
生物基因Ma公司 |
干扰素-β-1a的聚合物缀合物及其使用
|
|
DE19852729A1
(de)
|
1998-11-16 |
2000-05-18 |
Werner Reutter |
Rekombinante Glycoproteine, Verfahren zu ihrer Herstellung, sie enthaltende Arzneimittel und ihre Verwendung
|
|
CN101810854A
(zh)
|
1999-02-22 |
2010-08-25 |
巴克斯特国际公司 |
新的无白蛋白的因子viii制剂
|
|
US6531122B1
(en)
|
1999-08-27 |
2003-03-11 |
Maxygen Aps |
Interferon-β variants and conjugates
|
|
CN1309423C
(zh)
|
1999-11-12 |
2007-04-11 |
马克西根控股公司 |
干扰素γ偶联物
|
|
ATE428445T1
(de)
|
2000-02-11 |
2009-05-15 |
Bayer Healthcare Llc |
Gerinnungsfaktor vii oder viia konjugate
|
|
US6586398B1
(en)
|
2000-04-07 |
2003-07-01 |
Amgen, Inc. |
Chemically modified novel erythropoietin stimulating protein compositions and methods
|
|
EP1282693B1
(en)
|
2000-05-03 |
2010-10-20 |
Novo Nordisk Health Care AG |
Human coagulation factor vii variants
|
|
CA2414076A1
(en)
|
2000-06-08 |
2001-12-13 |
La Jolla Pharmaceutical Company |
Multivalent platform molecules comprising high molecular weight polyethylene oxide
|
|
US6423826B1
(en)
|
2000-06-30 |
2002-07-23 |
Regents Of The University Of Minnesota |
High molecular weight derivatives of vitamin K-dependent polypeptides
|
|
US7118737B2
(en)
|
2000-09-08 |
2006-10-10 |
Amylin Pharmaceuticals, Inc. |
Polymer-modified synthetic proteins
|
|
JP4361728B2
(ja)
|
2000-09-13 |
2009-11-11 |
ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト |
ヒト凝固因子ｖｉｉ変異型
|
|
EP2311943A3
(en)
*
|
2000-10-02 |
2011-05-04 |
Novo Nordisk Health Care AG |
Factor VII glycoforms
|
|
WO2002032957A1
(en)
|
2000-10-16 |
2002-04-25 |
Chugai Seiyaku Kabushiki Kaisha |
Peg-modified erythropoietin
|
|
ES2432967T3
(es)
|
2001-03-22 |
2013-12-05 |
Novo Nordisk Health Care Ag |
Derivados del Factor VII de coagulación
|
|
US6913915B2
(en)
|
2001-08-02 |
2005-07-05 |
Phoenix Pharmacologics, Inc. |
PEG-modified uricase
|
|
US8008252B2
(en)
*
|
2001-10-10 |
2011-08-30 |
Novo Nordisk A/S |
Factor VII: remodeling and glycoconjugation of Factor VII
|
|
EP2305313B1
(en)
|
2001-10-10 |
2014-03-26 |
ratiopharm GmbH |
Remodelling and glycoconjugation of interferon-alpha (IFNa)
|
|
US7795210B2
(en)
|
2001-10-10 |
2010-09-14 |
Novo Nordisk A/S |
Protein remodeling methods and proteins/peptides produced by the methods
|
|
US7214660B2
(en)
|
2001-10-10 |
2007-05-08 |
Neose Technologies, Inc. |
Erythropoietin: remodeling and glycoconjugation of erythropoietin
|
|
EP1446438A2
(en)
|
2001-11-07 |
2004-08-18 |
Nektar Therapeutics Al, Corporation |
Branched polymers and their conjugates
|
|
WO2003045980A2
(en)
|
2001-11-28 |
2003-06-05 |
Neose Technologies, Inc. |
Glycopeptide remodeling using amidases
|
|
CA2468295C
(en)
|
2001-11-28 |
2010-08-03 |
Neose Technologies, Inc. |
Glycoprotein remodeling using endoglycanases
|
|
DE60336555D1
(de)
|
2002-06-21 |
2011-05-12 |
Novo Nordisk Healthcare Ag |
Pegylierte glykoformen von faktor vii
|
|
CA2490360A1
(en)
*
|
2002-06-21 |
2003-12-31 |
Novo Nordisk Health Care Ag |
Pegylated factor vii glycoforms
|
|
US7122189B2
(en)
|
2002-08-13 |
2006-10-17 |
Enzon, Inc. |
Releasable polymeric conjugates based on aliphatic biodegradable linkers
|
|
US7087229B2
(en)
|
2003-05-30 |
2006-08-08 |
Enzon Pharmaceuticals, Inc. |
Releasable polymeric conjugates based on aliphatic biodegradable linkers
|
|
WO2004024761A1
(en)
|
2002-09-11 |
2004-03-25 |
Fresenius Kabi Deutschland Gmbh |
Hasylated polypeptides, especially hasylated erythropoietin
|
|
US20040062748A1
(en)
|
2002-09-30 |
2004-04-01 |
Mountain View Pharmaceuticals, Inc. |
Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof
|
|
EP1578841B2
(en)
|
2002-12-31 |
2016-10-12 |
Nektar Therapeutics AL, Corporation |
Maleamic acid polymer derivatives and their bioconjugates
|
|
CN100343304C
(zh)
|
2002-12-31 |
2007-10-17 |
尼克塔治疗亚拉巴马公司 |
水解稳定的马来酰亚胺封端的聚合物
|
|
KR101085375B1
(ko)
|
2003-02-26 |
2011-11-21 |
넥타르 테라퓨틱스 |
중합체-인자 ⅷ 부분 콘쥬게이트
|
|
US7691603B2
(en)
*
|
2003-04-09 |
2010-04-06 |
Novo Nordisk A/S |
Intracellular formation of peptide conjugates
|
|
BRPI0412671A
(pt)
|
2003-08-08 |
2006-10-03 |
Fresenius Kabi De Gmbh |
conjugados de um polìmero e uma proteìna ligados por um grupo de ligação de oxima
|
|
WO2005014035A2
(en)
|
2003-08-08 |
2005-02-17 |
Novo Nordisk Health Care Ag |
Use of galactose oxidase for selective chemical conjugation of protractor molecules to proteins of therapeutic interest
|
|
KR101113726B1
(ko)
|
2003-08-12 |
2012-02-27 |
리폭센 테크놀로지즈 리미티드 |
단백질 유도 및 컨쥬게이션용 시알산 유도체
|
|
EP1654289B1
(en)
|
2003-08-12 |
2007-10-03 |
Lipoxen Technologies Limited |
Polysialic acid derivatives
|
|
WO2005032581A2
(en)
|
2003-10-07 |
2005-04-14 |
Novo Nordisk Health Care Ag |
Hybrid molecules having factor vii/viia activity
|
|
WO2005055950A2
(en)
|
2003-12-03 |
2005-06-23 |
Neose Technologies, Inc. |
Glycopegylated factor ix
|
|
ES2560657T3
(es)
|
2004-01-08 |
2016-02-22 |
Ratiopharm Gmbh |
Glicosilación con unión en O de péptidos G-CSF
|
|
KR100651220B1
(ko)
|
2004-06-29 |
2006-11-29 |
씨제이 주식회사 |
Ｌ-메씨오닌 생산 균주 및 상기 균주를 이용한ｌ-메씨오닌의 생산방법
|
|
EP1786379A2
(en)
|
2004-07-14 |
2007-05-23 |
Mali Arel |
Feeding bottles
|
|
US20090292110A1
(en)
|
2004-07-23 |
2009-11-26 |
Defrees Shawn |
Enzymatic modification of glycopeptides
|
|
WO2006013202A2
(en)
|
2004-08-02 |
2006-02-09 |
Novo Nordisk Health Care Ag |
Conjugation of fvii
|
|
EP1776389B1
(en)
*
|
2004-08-12 |
2016-06-29 |
Lipoxen Technologies Limited |
Sialic acid derivatives
|
|
ES2821832T3
(es)
|
2004-11-12 |
2021-04-27 |
Bayer Healthcare Llc |
Modificación de FVIII dirigida al sitio
|
|
JP5022231B2
(ja)
*
|
2004-12-27 |
2012-09-12 |
バクスター・インターナショナル・インコーポレイテッド |
ポリマー−フォンビルブラント因子結合体
|
|
EP1838332A1
(en)
|
2005-01-06 |
2007-10-03 |
Neose Technologies, Inc. |
Glycoconjugation using saccharyl fragments
|
|
EP1853634B1
(en)
*
|
2005-02-23 |
2016-08-10 |
Lipoxen Technologies Limited |
Activated sialic acid derivatives for protein derivatisation and conjugation
|
|
AU2006222187A1
(en)
*
|
2005-03-11 |
2006-09-14 |
Fresenius Kabi Deutschland Gmbh |
Production of bioactive glycoproteins from inactive starting material by conjugation with hydroxyalkylstarch
|
|
JP5216580B2
(ja)
|
2005-05-25 |
2013-06-19 |
ノヴォ ノルディスク アー／エス |
グリコペグ化第ｉｘ因子
|
|
US8633300B2
(en)
|
2005-06-17 |
2014-01-21 |
Novo Nordisk Healthcare Ag |
Selective reduction and derivatization of engineered proteins comprising at least one non-native cysteine
|
|
EP1919498A2
(en)
|
2005-08-26 |
2008-05-14 |
Maxygen Holdings Ltd. |
Liquid factor vii composition
|
|
EP1962907A2
(en)
|
2005-12-21 |
2008-09-03 |
Wyeth a Corporation of the State of Delaware |
Protein formulations with reduced viscosity and uses thereof
|
|
US7985839B2
(en)
|
2006-03-31 |
2011-07-26 |
Baxter International Inc. |
Factor VIII polymer conjugates
|
|
US7645860B2
(en)
|
2006-03-31 |
2010-01-12 |
Baxter Healthcare S.A. |
Factor VIII polymer conjugates
|
|
KR20080108147A
(ko)
|
2006-03-31 |
2008-12-11 |
백스터 인터내셔널 인코포레이티드 |
페질화된 인자 ｖｉｉｉ
|
|
US7982010B2
(en)
|
2006-03-31 |
2011-07-19 |
Baxter International Inc. |
Factor VIII polymer conjugates
|
|
US20090285780A1
(en)
|
2006-05-24 |
2009-11-19 |
Chyi Lee |
Peg linker compounds and biologically active conjugates thereof
|
|
JP2007319283A
(ja)
*
|
2006-05-31 |
2007-12-13 |
Nippon Sherwood Medical Industries Ltd |
医療用バッグ
|
|
US7939632B2
(en)
|
2006-06-14 |
2011-05-10 |
Csl Behring Gmbh |
Proteolytically cleavable fusion proteins with high molar specific activity
|
|
ES2565180T3
(es)
|
2006-07-13 |
2016-04-01 |
Serum Institute Of India Ltd, |
Proceso para la preparación de ácido polisiálico de gran pureza
|
|
JP5096466B2
(ja)
|
2006-07-25 |
2012-12-12 |
リポクセン テクノロジーズ リミテッド |
Ｎ末端ポリシアリル化
|
|
US8969532B2
(en)
|
2006-10-03 |
2015-03-03 |
Novo Nordisk A/S |
Methods for the purification of polypeptide conjugates comprising polyalkylene oxide using hydrophobic interaction chromatography
|
|
EP2101821B1
(en)
*
|
2006-12-15 |
2014-08-13 |
Baxter International Inc. |
Factor viia- (poly) sialic acid conjugate having prolonged in vivo half-life
|
|
WO2008081024A1
(en)
|
2007-01-03 |
2008-07-10 |
Novo Nordisk Health Care Ag |
Subcutaneous administration of coagulation factor viia-related popypeptdes
|
|
WO2008119815A1
(en)
|
2007-04-02 |
2008-10-09 |
Novo Nordisk A/S |
Subcutaneous administration of coagulation factor ix
|
|
MX2009013682A
(es)
|
2007-06-26 |
2010-08-31 |
Baxter Int |
Enlazador de fmoc polimerico hidrolizable.
|
|
JP5702600B2
(ja)
|
2007-07-03 |
2015-04-15 |
チルドレンズ ホスピタル アンド リサーチ センター アット オークランド |
オリゴシアル酸誘導体、製造方法および免疫学的使用
|
|
ES2597849T3
(es)
|
2007-10-09 |
2017-01-23 |
Polytherics Limited |
Proteínas y péptidos conjugados novedosos
|
|
JP5647899B2
(ja)
|
2008-01-08 |
2015-01-07 |
ラツィオファルム ゲーエムベーハーｒａｔｉｏｐｈａｒｍ ＧｍｂＨ |
オリゴサッカリルトランスフェラーゼを使用するポリペプチドの複合糖質化
|
|
KR101582841B1
(ko)
|
2008-02-27 |
2016-01-11 |
노보 노르디스크 에이/에스 |
콘쥬게이트된 인자 ｖｉｉｉ 분자
|
|
MX2010011672A
(es)
|
2008-04-24 |
2011-03-02 |
Celtic Pharma Peg Ltd |
Conjugados del factor ix con vidas medias extendidas.
|
|
CN102065899A
(zh)
|
2008-05-23 |
2011-05-18 |
诺沃-诺迪斯克保健股份有限公司 |
含有高浓度的芳香族防腐剂的peg-官能化的丝氨酸蛋白酶的制剂
|
|
CN102083459A
(zh)
|
2008-05-23 |
2011-06-01 |
诺沃-诺迪斯克保健股份有限公司 |
包括含有peg化的gla-结构域的蛋白质的低粘度组合物
|
|
AU2009256093A1
(en)
|
2008-06-04 |
2009-12-10 |
Bayer Healthcare Llc |
FVIII muteins for treatment of von Willebrand disease
|
|
DK2374481T3
(en)
|
2008-07-21 |
2016-02-01 |
Polytherics Ltd |
New reagents and methods for the conjugation of biological molecules
|
|
KR20110093775A
(ko)
|
2008-11-03 |
2011-08-18 |
바이엘 헬스케어 엘엘씨 |
혈우병 치료 방법
|
|
WO2010083536A1
(en)
|
2009-01-19 |
2010-07-22 |
Bayer Healthcare Llc |
Protein conjugate having an endopeptidase-cleavable bioprotective moiety
|
|
JP2012518029A
(ja)
|
2009-02-19 |
2012-08-09 |
ノヴォ・ノルディスク・アー／エス |
第ｖｉｉｉ因子の修飾
|
|
WO2010100430A1
(en)
|
2009-03-04 |
2010-09-10 |
Polytherics Limited |
Conjugated proteins and peptides
|
|
US20100330033A1
(en)
|
2009-04-16 |
2010-12-30 |
Nian Wu |
Protein-carrier conjugates
|
|
GB0908393D0
(en)
|
2009-05-15 |
2009-06-24 |
Almac Sciences Scotland Ltd |
Labelling method
|
|
MX2012001207A
(es)
|
2009-07-27 |
2012-05-08 |
Baxter Int |
Conjugados proteicos de coagulacion sanguínea.
|
|
JP5909755B2
(ja)
|
2009-07-27 |
2016-04-27 |
リポクセン テクノロジーズ リミテッド |
非血液凝固タンパク質の糖ポリシアル酸化
|
|
PE20121643A1
(es)
|
2009-07-31 |
2012-11-25 |
Bayer Healthcare Llc |
Polipeptidos del factor ix modificados y usos de los mismos
|
|
DE102009028526A1
(de)
|
2009-08-13 |
2011-02-24 |
Leibniz-Institut Für Polymerforschung Dresden E.V. |
Verfahren zur Modifikation und Funktionalisierung von Sacchariden
|
|
WO2011037896A2
(en)
|
2009-09-25 |
2011-03-31 |
Vybion, Inc. |
Polypeptide modification
|
|
WO2011064247A1
(en)
|
2009-11-24 |
2011-06-03 |
Novo Nordisk Health Care Ag |
Method of purifying pegylated proteins
|
|
JP5914363B2
(ja)
|
2010-02-16 |
2016-05-11 |
ノヴォ ノルディスク アー／エス |
低減されたｖｗｆ結合を有する因子ｖｉｉｉ分子
|
|
GB201007357D0
(en)
|
2010-04-30 |
2010-06-16 |
Leverton Licence Holdings Ltd |
Conjugated factor VIII
|
|
GB201007356D0
(en)
|
2010-04-30 |
2010-06-16 |
Leverton Licence Holdings Ltd |
Conjugated factor VIIa
|
|
EP2640483A1
(en)
|
2010-11-15 |
2013-09-25 |
Biogen Idec Inc. |
Enrichment and concentration of select product isoforms by overloaded bind and elute chromatography
|
|
HUE043763T2
(hu)
|
2011-07-08 |
2019-09-30 |
Bioverativ Therapeutics Inc |
VIII-as faktor kiméra és hibrid polipeptidek, és azok alkalmazási eljárásai
|