RU2005140285A - Производные карбостирила и стабилизаторы настроения для лечения расстройств настроения - Google Patents
Производные карбостирила и стабилизаторы настроения для лечения расстройств настроения Download PDFInfo
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- RU2005140285A RU2005140285A RU2005140285/15A RU2005140285A RU2005140285A RU 2005140285 A RU2005140285 A RU 2005140285A RU 2005140285/15 A RU2005140285/15 A RU 2005140285/15A RU 2005140285 A RU2005140285 A RU 2005140285A RU 2005140285 A RU2005140285 A RU 2005140285A
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- Prior art keywords
- mood
- treatment
- stabilizer
- composition
- oxcarbamazepine
- Prior art date
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- 229940127237 mood stabilizer Drugs 0.000 title claims 7
- 239000004050 mood stabilizer Substances 0.000 title claims 7
- 208000019022 Mood disease Diseases 0.000 title claims 6
- 239000000203 mixture Substances 0.000 claims 12
- UGJMXCAKCUNAIE-UHFFFAOYSA-N Gabapentin Chemical compound OC(=O)CC1(CN)CCCCC1 UGJMXCAKCUNAIE-UHFFFAOYSA-N 0.000 claims 8
- 238000000034 method Methods 0.000 claims 6
- LISFMEBWQUVKPJ-UHFFFAOYSA-N quinolin-2-ol Chemical class C1=CC=C2NC(=O)C=CC2=C1 LISFMEBWQUVKPJ-UHFFFAOYSA-N 0.000 claims 5
- CEUORZQYGODEFX-UHFFFAOYSA-N Aripirazole Chemical compound ClC1=CC=CC(N2CCN(CCCCOC=3C=C4NC(=O)CCC4=CC=3)CC2)=C1Cl CEUORZQYGODEFX-UHFFFAOYSA-N 0.000 claims 4
- KJADKKWYZYXHBB-XBWDGYHZSA-N Topiramic acid Chemical compound C1O[C@@]2(COS(N)(=O)=O)OC(C)(C)O[C@H]2[C@@H]2OC(C)(C)O[C@@H]21 KJADKKWYZYXHBB-XBWDGYHZSA-N 0.000 claims 4
- FFGPTBGBLSHEPO-UHFFFAOYSA-N carbamazepine Chemical compound C1=CC2=CC=CC=C2N(C(=O)N)C2=CC=CC=C21 FFGPTBGBLSHEPO-UHFFFAOYSA-N 0.000 claims 4
- 229960000623 carbamazepine Drugs 0.000 claims 4
- DGBIGWXXNGSACT-UHFFFAOYSA-N clonazepam Chemical compound C12=CC([N+](=O)[O-])=CC=C2NC(=O)CN=C1C1=CC=CC=C1Cl DGBIGWXXNGSACT-UHFFFAOYSA-N 0.000 claims 4
- 229960003120 clonazepam Drugs 0.000 claims 4
- 229960002870 gabapentin Drugs 0.000 claims 4
- PYZRQGJRPPTADH-UHFFFAOYSA-N lamotrigine Chemical compound NC1=NC(N)=NN=C1C1=CC=CC(Cl)=C1Cl PYZRQGJRPPTADH-UHFFFAOYSA-N 0.000 claims 4
- 229960001848 lamotrigine Drugs 0.000 claims 4
- 229960004002 levetiracetam Drugs 0.000 claims 4
- HPHUVLMMVZITSG-ZCFIWIBFSA-N levetiracetam Chemical compound CC[C@H](C(N)=O)N1CCCC1=O HPHUVLMMVZITSG-ZCFIWIBFSA-N 0.000 claims 4
- CTRLABGOLIVAIY-UHFFFAOYSA-N oxcarbazepine Chemical compound C1C(=O)C2=CC=CC=C2N(C(=O)N)C2=CC=CC=C21 CTRLABGOLIVAIY-UHFFFAOYSA-N 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 229960004394 topiramate Drugs 0.000 claims 4
- MSRILKIQRXUYCT-UHFFFAOYSA-M valproate semisodium Chemical compound [Na+].CCCC(C(O)=O)CCC.CCCC(C([O-])=O)CCC MSRILKIQRXUYCT-UHFFFAOYSA-M 0.000 claims 4
- UBQNRHZMVUUOMG-UHFFFAOYSA-N zonisamide Chemical compound C1=CC=C2C(CS(=O)(=O)N)=NOC2=C1 UBQNRHZMVUUOMG-UHFFFAOYSA-N 0.000 claims 4
- 229960002911 zonisamide Drugs 0.000 claims 4
- 229940126601 medicinal product Drugs 0.000 claims 3
- UDQMXYJSNNCRAS-UHFFFAOYSA-N 2,3-dichlorophenylpiperazine Chemical compound ClC1=CC=CC(N2CCNCC2)=C1Cl UDQMXYJSNNCRAS-UHFFFAOYSA-N 0.000 claims 2
- CDONPRYEWWPREK-UHFFFAOYSA-N 7-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy]-1h-quinolin-2-one Chemical group ClC1=CC=CC(N2CCN(CCCCOC=3C=C4NC(=O)C=CC4=CC=3)CC2)=C1Cl CDONPRYEWWPREK-UHFFFAOYSA-N 0.000 claims 2
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical group [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 claims 2
- 229960004372 aripiprazole Drugs 0.000 claims 2
- NIJJYAXOARWZEE-UHFFFAOYSA-N di-n-propyl-acetic acid Natural products CCCC(C(O)=O)CCC NIJJYAXOARWZEE-UHFFFAOYSA-N 0.000 claims 2
- 229940028937 divalproex sodium Drugs 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 229960001078 lithium Drugs 0.000 claims 2
- 229910052744 lithium Inorganic materials 0.000 claims 2
- 239000002207 metabolite Substances 0.000 claims 2
- 229960000604 valproic acid Drugs 0.000 claims 2
- 208000020925 Bipolar disease Diseases 0.000 claims 1
- 206010026749 Mania Diseases 0.000 claims 1
- 229940076279 serotonin Drugs 0.000 claims 1
- 239000003381 stabilizer Substances 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
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- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
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- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
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- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/423—Oxazoles condensed with carbocyclic rings
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- A61K31/425—Thiazoles
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4704—2-Quinolinones, e.g. carbostyril
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- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
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- A—HUMAN NECESSITIES
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- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Inorganic Chemistry (AREA)
- Psychiatry (AREA)
- Molecular Biology (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Claims (16)
1. Композиция, содержащая, по меньшей мере, одно производное карбостирила в комбинации, по меньшей мере, с одним стабилизатором настроения.
2. Композиция по п.1, в которой производное карбостирила представляет собой стабилизатор допамин-серотониновой системы.
3. Композиция по п.2, в которой производное карбостирила представляет собой арипипразол или его метаболит.
4. Композиция по п.3, в которой метаболитом арипипразола является дегидроарипипразол, DM-1458, DM-1451, DM-1452, DM-1454 или DCPP.
5. Композиция по п.1, в которой, по меньшей мере, один стабилизатор настроения представляет собой литий, вальпроевую кислоту, дивальпроекс натрия, карбамазепин, окскарбамазепин, зонисамид, ламотригин, топирамат, габапентин, леветирацетам или клоназепам, или его соль.
6. Композиция по п.1, в которой, по меньшей мере, один стабилизатор настроения представляет собой карбамазепин, окскарбамазепин, зонисамид, ламотригин, топирамат, габапентин, леветирацетам или клоназепам, или его соль.
7. Композиция по п.1, которая дополнительно содержит, по меньшей мере, один фармацевтически приемлемый носитель.
8. Применение композиций по любому из пп.1-7 в приготовлении лекарственного средства, предназначенного для лечения расстройств настроения.
9. Применение композиций по любому из пп.1-7 в приготовлении лекарственного средства, предназначенного для лечения биполярного расстройства.
10. Применение композиций по любому из пп.1-7 в приготовлении лекарственного средства, предназначенного для лечения маниакального синдрома.
11. Способ лечения расстройства настроения у пациента, включающий введение любой из композиций по пп.1-7 в фармацевтически приемлемом носителе, где количество данной композиции является эффективным для лечения расстройства настроения у пациента.
12. Способ лечения расстройства настроения у пациента, включающий раздельное введение первого количества производного карбостирила и второго количества стабилизатора настроения, где введение является эффективным для лечения расстройства настроения у пациента.
13. Способ по п.12, в котором производное карбостирила представляет собой арипипразол или его метаболит.
14. Способ по п.13, в котором метаболит арипипразола представляет собой дегидроарипипразол, DM-1458, DM-1451, DM-1452, DM-1454 или DCPP.
15. Способ по п.12, при котором стабилизатор настроения представляет собой литий, вальпроевую кислоту, дивальпроекс натрия, карбамазепин, окскарбамазепин, зонисамид, ламотригин, топирамат, габапентин, леветирацетам или клоназепам, или его соль.
16. Способ по п.15, при котором стабилизатор настроения представляет собой карбамазепин, окскарбамазепин, зонисамид, ламотригин, топирамат, габапентин, леветирацетам или клоназепам, или его соль.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US47337803P | 2003-05-23 | 2003-05-23 | |
| US60/473,378 | 2003-05-23 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2005140285A true RU2005140285A (ru) | 2006-06-10 |
| RU2359675C2 RU2359675C2 (ru) | 2009-06-27 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2005140285A RU2359675C2 (ru) | 2003-05-23 | 2004-05-19 | Производные карбостирила и стабилизаторы настроения для лечения расстройств настроения |
Country Status (27)
| Country | Link |
|---|---|
| US (5) | US9125939B2 (ru) |
| EP (2) | EP2601953A1 (ru) |
| JP (2) | JP4693778B2 (ru) |
| KR (1) | KR100881046B1 (ru) |
| CN (5) | CN102172401A (ru) |
| AU (1) | AU2004243096B2 (ru) |
| BR (1) | BRPI0410786A (ru) |
| CA (1) | CA2526562C (ru) |
| CO (1) | CO5630025A2 (ru) |
| CY (1) | CY1118313T1 (ru) |
| DK (1) | DK1626721T3 (ru) |
| EC (1) | ECSP056182A (ru) |
| ES (1) | ES2609382T3 (ru) |
| GE (1) | GEP20084567B (ru) |
| HU (1) | HUE030014T2 (ru) |
| IL (3) | IL171414A (ru) |
| LT (1) | LT1626721T (ru) |
| MX (1) | MXPA05012538A (ru) |
| NO (1) | NO332764B1 (ru) |
| NZ (1) | NZ542985A (ru) |
| PL (1) | PL1626721T3 (ru) |
| PT (1) | PT1626721T (ru) |
| RU (1) | RU2359675C2 (ru) |
| TW (1) | TWI342776B (ru) |
| UA (1) | UA92453C2 (ru) |
| WO (1) | WO2004105682A2 (ru) |
| ZA (1) | ZA200508306B (ru) |
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| US7053092B2 (en) * | 2001-01-29 | 2006-05-30 | Otsuka Pharmaceutical Co., Ltd. | 5-HT1a receptor subtype agonist |
| AR033485A1 (es) | 2001-09-25 | 2003-12-26 | Otsuka Pharma Co Ltd | Sustancia medicinal de aripiprazol de baja higroscopicidad y proceso para la preparacion de la misma |
| NZ556779A (en) | 2002-12-27 | 2008-12-24 | Otsuka Pharma Co Ltd | Carbostyril derivatives and serotonin reuptake inhibitors for treatment of mood disorders |
| DE05815688T1 (de) | 2005-01-27 | 2008-06-26 | Alembic Ltd. | Levetiracetam-formulierung mit verlängerter freisetzung |
| TWI320783B (en) | 2005-04-14 | 2010-02-21 | Otsuka Pharma Co Ltd | Heterocyclic compound |
| DK1909764T3 (da) * | 2005-07-26 | 2014-12-15 | Ucb Pharma Sa | Farmaceutisk sammensætninger omfattende levetiracetam og fremgangsmåde til deres fremstilling |
| US20080014264A1 (en) * | 2006-07-13 | 2008-01-17 | Ucb, S.A. | Novel pharmaceutical compositions comprising levetiracetam |
| US8247420B2 (en) * | 2007-05-21 | 2012-08-21 | Reviva Pharmaceuticals, Inc. | Compositions, synthesis, and methods of using quinolinone based atypical antipsychotic agents |
| GB2456183A (en) * | 2008-01-04 | 2009-07-08 | Gw Pharma Ltd | Anti-psychotic composition comprising cannabinoids and anti-psychotic medicament |
| CN102413830A (zh) | 2009-02-26 | 2012-04-11 | 雷维瓦药品公司 | 利用芳基哌嗪衍生物的组合物、合成及方法 |
| WO2010151711A1 (en) * | 2009-06-25 | 2010-12-29 | Alkermes, Inc. | Prodrugs of nh-acidic compounds |
| PL2445502T5 (pl) * | 2009-06-25 | 2023-03-13 | Alkermes Pharma Ireland Limited | Związki heterocykliczne do leczenia zaburzeń neurologicznych i psychologicznych |
| ES2691671T3 (es) | 2010-06-24 | 2018-11-28 | Alkermes Pharma Ireland Limited | Profármacos de compuestos NH-acídicos: derivados de éster, carbonato, carbamato y fosfonato |
| CA2826765C (en) * | 2011-02-09 | 2021-04-06 | The Johns Hopkins University | Methods and compositions for improving cognitive function |
| US9034867B2 (en) | 2011-03-18 | 2015-05-19 | Alkermes Pharma Ireland Limited | Pharmaceutical compositions comprising sorbitan esters |
| CA2858787C (en) | 2011-12-15 | 2017-11-21 | Alkermes Pharma Ireland Limited | Prodrugs of tertiary amine compounds |
| JP6219918B2 (ja) | 2012-03-19 | 2017-10-25 | アルカームス ファーマ アイルランド リミテッド | グリセロールエステルを含む医薬組成物 |
| NZ630643A (en) | 2012-03-19 | 2017-08-25 | Alkermes Pharma Ireland Ltd | Pharmaceutical compositions comprising fatty acid esters |
| CA2867137C (en) | 2012-03-19 | 2020-12-08 | Alkermes Pharma Ireland Limited | Pharmaceutical compositions comprising aripiprazole prodrugs and benzyl alcohol |
| JOP20200109A1 (ar) | 2012-04-23 | 2017-06-16 | Otsuka Pharma Co Ltd | مستحضر قابل للحقن |
| US9193685B2 (en) | 2012-09-19 | 2015-11-24 | Alkermes Pharma Ireland Limited | Pharmaceutical compositions having improved storage stability |
| WO2014078568A1 (en) | 2012-11-14 | 2014-05-22 | The Johns Hopkins University | Methods and compositions for treating schizophrenia |
| US8652527B1 (en) | 2013-03-13 | 2014-02-18 | Upsher-Smith Laboratories, Inc | Extended-release topiramate capsules |
| EP3827820A1 (en) | 2013-03-15 | 2021-06-02 | The Johns Hopkins University | Brivaracetam for improving cognitive function |
| US11160785B2 (en) | 2013-03-15 | 2021-11-02 | Agenebio Inc. | Methods and compositions for improving cognitive function |
| US9101545B2 (en) | 2013-03-15 | 2015-08-11 | Upsher-Smith Laboratories, Inc. | Extended-release topiramate capsules |
| CN103550778B (zh) * | 2013-11-18 | 2015-12-30 | 四川科瑞德制药有限公司 | 一种治疗情感性精神障碍疾病的药物组合物 |
| AU2015231278B2 (en) | 2014-03-20 | 2020-01-23 | Alkermes Pharma Ireland Limited | Aripiprazole formulations having increased injection speeds |
| BR112017025031B1 (pt) | 2015-05-22 | 2023-03-21 | Agenebio, Inc | Composições farmacêuticas de liberação prolongada de levetiracetam |
| CN108623520A (zh) * | 2017-03-16 | 2018-10-09 | 重庆医药工业研究院有限责任公司 | 阿立哌唑缩醛月桂酸酯的制备方法 |
| JP7384812B2 (ja) | 2018-03-05 | 2023-11-21 | アルカームス ファーマ アイルランド リミテッド | アリピプラゾール投与戦略 |
| JP7211136B2 (ja) * | 2019-02-14 | 2023-01-24 | ニプロ株式会社 | 錠剤、および、その製造方法 |
| US20240009181A1 (en) * | 2022-07-08 | 2024-01-11 | Jason Eric Schiffman | Method for the treatment and prophylaxis of substance-related and/or addictive disorders including substance/medication-induced depressive disorders, bipolar and related disorders, and anxiety disorders and compositions useful for the same |
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| US5006528A (en) | 1988-10-31 | 1991-04-09 | Otsuka Pharmaceutical Co., Ltd. | Carbostyril derivatives |
| JP2608788B2 (ja) | 1988-10-31 | 1997-05-14 | 大塚製薬 株式会社 | 精神分裂病治療剤 |
| JPH04284524A (ja) * | 1991-03-14 | 1992-10-09 | Matsushita Electric Ind Co Ltd | キー入力装置 |
| WO1997035584A1 (en) * | 1996-03-25 | 1997-10-02 | Eli Lilly And Company | Method for treating pain |
| CZ20004280A3 (cs) * | 1998-05-29 | 2001-09-12 | Eli Lilly And Company | Lék pro léčbu bipolárních poruch a farmaceutický prostředek |
| US20030027817A1 (en) | 1998-05-29 | 2003-02-06 | Tollefson Gary Dennis | Combination therapy for treatment of bipolar disorders |
| DK1158973T3 (da) | 1999-02-24 | 2005-05-30 | Univ Cincinnati | Anvendelse af sulfamatderivater til behandling af impulskontrolafvigelser |
| JP2002541098A (ja) | 1999-04-06 | 2002-12-03 | セプラコア インコーポレーテッド | ジプラシドン代謝産物を用いる神経弛緩薬性障害および関連障害を治療するための方法および組成物 |
| AU2002232470B2 (en) * | 2001-01-02 | 2005-11-03 | Pharmacia & Upjohn Company Llc | New drug combinations of norepinehrine reuptake inhibitors and neuroleptic agents |
| US7053092B2 (en) | 2001-01-29 | 2006-05-30 | Otsuka Pharmaceutical Co., Ltd. | 5-HT1a receptor subtype agonist |
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| EP1404342A1 (en) | 2001-04-26 | 2004-04-07 | Ortho-Mcneil Pharmaceutical, Inc. | Treatment of psychotic disorders comprising co-therapy with anticonvulsant derivatives and atypical antipsychotics |
| AR033485A1 (es) * | 2001-09-25 | 2003-12-26 | Otsuka Pharma Co Ltd | Sustancia medicinal de aripiprazol de baja higroscopicidad y proceso para la preparacion de la misma |
| WO2003066039A1 (en) | 2002-02-08 | 2003-08-14 | Abbott Laboratories | Combination therapy for treatment of schizophrenia |
| NZ556779A (en) * | 2002-12-27 | 2008-12-24 | Otsuka Pharma Co Ltd | Carbostyril derivatives and serotonin reuptake inhibitors for treatment of mood disorders |
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