JP2008525491A5 - - Google Patents
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- JP2008525491A5 JP2008525491A5 JP2007548552A JP2007548552A JP2008525491A5 JP 2008525491 A5 JP2008525491 A5 JP 2008525491A5 JP 2007548552 A JP2007548552 A JP 2007548552A JP 2007548552 A JP2007548552 A JP 2007548552A JP 2008525491 A5 JP2008525491 A5 JP 2008525491A5
- Authority
- JP
- Japan
- Prior art keywords
- fviii
- vwf
- construct
- life
- molecule
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63924404P | 2004-12-27 | 2004-12-27 | |
| US60/639,244 | 2004-12-27 | ||
| US66837805P | 2005-04-04 | 2005-04-04 | |
| US60/668,378 | 2005-04-04 | ||
| US67190105P | 2005-04-15 | 2005-04-15 | |
| US60/671,901 | 2005-04-15 | ||
| US68508605P | 2005-05-26 | 2005-05-26 | |
| US60/685,086 | 2005-05-26 | ||
| PCT/US2005/046879 WO2006071801A2 (en) | 2004-12-27 | 2005-12-23 | Polymer-von willebrand factor-conjugates |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012081700A Division JP5715983B2 (ja) | 2004-12-27 | 2012-03-30 | ポリマー−フォンビルブラント因子結合体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008525491A JP2008525491A (ja) | 2008-07-17 |
| JP2008525491A5 true JP2008525491A5 (enExample) | 2009-02-12 |
| JP5022231B2 JP5022231B2 (ja) | 2012-09-12 |
Family
ID=36540284
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007548552A Expired - Lifetime JP5022231B2 (ja) | 2004-12-27 | 2005-12-23 | ポリマー−フォンビルブラント因子結合体 |
| JP2012081700A Expired - Lifetime JP5715983B2 (ja) | 2004-12-27 | 2012-03-30 | ポリマー−フォンビルブラント因子結合体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012081700A Expired - Lifetime JP5715983B2 (ja) | 2004-12-27 | 2012-03-30 | ポリマー−フォンビルブラント因子結合体 |
Country Status (15)
| Country | Link |
|---|---|
| US (4) | US7884075B2 (enExample) |
| EP (1) | EP1835938B1 (enExample) |
| JP (2) | JP5022231B2 (enExample) |
| KR (1) | KR20070092754A (enExample) |
| CN (1) | CN101163506B (enExample) |
| AU (1) | AU2005322067B8 (enExample) |
| BR (1) | BRPI0519562A2 (enExample) |
| CA (1) | CA2591852A1 (enExample) |
| DK (1) | DK1835938T3 (enExample) |
| ES (1) | ES2434035T3 (enExample) |
| IL (1) | IL183634A (enExample) |
| MX (1) | MX2007007877A (enExample) |
| PL (1) | PL1835938T3 (enExample) |
| PT (1) | PT1835938E (enExample) |
| WO (1) | WO2006071801A2 (enExample) |
Families Citing this family (74)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6263355A (ja) * | 1985-09-13 | 1987-03-20 | Hitachi Ltd | バツテリバツクアツプramのチエツク方法 |
| DK1835938T3 (da) | 2004-12-27 | 2013-11-04 | Baxter Int | Polymer-von Willebrand-faktor-konjugater |
| US7645860B2 (en) | 2006-03-31 | 2010-01-12 | Baxter Healthcare S.A. | Factor VIII polymer conjugates |
| US7985839B2 (en) | 2006-03-31 | 2011-07-26 | Baxter International Inc. | Factor VIII polymer conjugates |
| JP2009532351A (ja) | 2006-03-31 | 2009-09-10 | バクスター・インターナショナル・インコーポレイテッド | ペグ化第viii因子 |
| US7982010B2 (en) | 2006-03-31 | 2011-07-19 | Baxter International Inc. | Factor VIII polymer conjugates |
| JP5570809B2 (ja) | 2006-09-01 | 2014-08-13 | ノボ ノルディスク ヘルス ケア アーゲー | 修飾タンパク質 |
| CN101557830B (zh) * | 2006-12-15 | 2016-06-08 | 巴克斯特国际公司 | 具有延长的体内半衰期的因子VIIa-聚唾液酸结合物 |
| AU2007340382B2 (en) | 2006-12-27 | 2013-06-27 | Nektar Therapeutics | Von Willebrand Factor- and Factor VIII-polymer conjugates having a releasable linkage |
| DK2152735T3 (en) * | 2007-05-18 | 2015-04-20 | Baxter Int | METHOD FOR PRODUCING mature VWF FROM VWF PRO-PEPTIDE |
| EP2486936A1 (en) | 2007-06-13 | 2012-08-15 | CSL Behring GmbH | A composition comprising VWF and FVIII preparations for use in treating of bleeding disorders |
| AU2008267360B2 (en) | 2007-06-26 | 2013-09-12 | Takeda Pharmaceutical Company Limited | Hydrolysable polymeric Fmoc-linker |
| KR20100095441A (ko) * | 2007-11-09 | 2010-08-30 | 백스터 인터내셔널 인코포레이티드 | 변형된 재조합 인자 ⅷ 및 폰 빌레브란트 인자 및 사용 방법 |
| NZ585530A (en) * | 2007-12-27 | 2012-06-29 | Baxter Int | Methods for differentiating plasma-derived protein from recombinant protein in a sample |
| AU2008345183B2 (en) | 2007-12-27 | 2014-08-21 | Baxalta GmbH | Method and compositions for specifically detecting physiologically acceptable polymer molecules |
| TWI600437B (zh) | 2007-12-28 | 2017-10-01 | 巴克斯歐塔公司 | 重組vwf調配物 |
| US11197916B2 (en) | 2007-12-28 | 2021-12-14 | Takeda Pharmaceutical Company Limited | Lyophilized recombinant VWF formulations |
| CA2710567A1 (en) | 2007-12-31 | 2009-07-16 | Baxter Healthcare S.A. | Transgenic non-human animals expressing human blood clotting factors |
| WO2009135888A2 (en) * | 2008-05-06 | 2009-11-12 | Octapharma Ag | Complex |
| ES2531464T3 (es) * | 2008-06-24 | 2015-03-16 | Csl Behring Gmbh | Factor VIII, factor de von Willebrand o sus complejos con semivida in vivo prolongada |
| KR101200659B1 (ko) * | 2008-07-23 | 2012-11-12 | 한미사이언스 주식회사 | 세 말단 반응기를 갖는 비펩타이드성 중합체를 이용한 생리활성 폴리펩타이드 약물 결합체 |
| WO2010014258A2 (en) * | 2008-08-01 | 2010-02-04 | Nektar Therapeutics Al, Corporation | Conjugates having a releasable linkage |
| MX2011004085A (es) | 2008-10-17 | 2011-09-27 | Baxter International | Factores sanguineos modificados que comprenden un bajo grado de polimero soluble en agua. |
| EP2337794B1 (en) * | 2008-10-20 | 2013-07-31 | USV Limited | An improved process for pegylation of proteins |
| HRP20130414T1 (en) * | 2008-10-21 | 2013-06-30 | Baxter International Inc. | Lyophilized recombinant vwf formulations |
| DK2431741T3 (da) * | 2008-10-21 | 2013-10-21 | Baxter Int | Fremgangsmåde til bestemmelse af virksomme bestanddele i profarmaka-PEG-proteinkonjugat |
| AU2009324447B2 (en) * | 2008-12-11 | 2016-02-25 | Takeda Pharmaceutical Company Limited | Detection of physiologically acceptable polymer molecules using near infrared spectroscopy |
| CA2769244A1 (en) | 2009-07-27 | 2011-02-03 | Lipoxen Technologies Limited | Glycopolysialylation of non-blood coagulation proteins |
| RU2595442C2 (ru) | 2009-07-27 | 2016-08-27 | Баксалта Инкорпорейтед | Конъюгаты белков свертывания крови |
| US8809501B2 (en) | 2009-07-27 | 2014-08-19 | Baxter International Inc. | Nucleophilic catalysts for oxime linkage |
| CN104530182A (zh) | 2009-07-27 | 2015-04-22 | 利普森技术有限公司 | 非凝血蛋白的糖基多唾液酸化 |
| US8642737B2 (en) | 2010-07-26 | 2014-02-04 | Baxter International Inc. | Nucleophilic catalysts for oxime linkage |
| US20110072524A1 (en) * | 2009-08-04 | 2011-03-24 | Baxter International Inc. | Transgenic Mouse Lacking Endogenous FVIII and VWF - A Model of Hemophilia A |
| HUE026907T2 (en) | 2009-08-20 | 2016-07-28 | Baxalta Inc | Clean VWF to enhance removal of non-lipid enveloped viruses |
| US20120263701A1 (en) | 2009-08-24 | 2012-10-18 | Volker Schellenberger | Coagulation factor vii compositions and methods of making and using same |
| RU2579977C2 (ru) * | 2009-11-13 | 2016-04-10 | Грифольс Терапьютикс Инк. | СОДЕРЖАЩИЕ ФАКТОР ФОН ВИЛЛЕБРАНДА (vWF) ПРЕПАРАТЫ И СПОСОБЫ, НАБОРЫ И ПРИМЕНЕНИЯ, СВЯЗАННЫЕ С НИМИ |
| GB201007357D0 (en) * | 2010-04-30 | 2010-06-16 | Leverton Licence Holdings Ltd | Conjugated factor VIII |
| KR102325780B1 (ko) | 2010-07-30 | 2021-11-12 | 박스알타 인코퍼레이티드 | 옥심 결합용 친핵성 촉매 |
| KR101309566B1 (ko) * | 2010-12-10 | 2013-09-17 | 포항공과대학교 산학협력단 | 히알루론산-단백질 컨쥬게이트 및 이의 제조 방법 |
| BR112013015898A2 (pt) | 2010-12-22 | 2018-06-26 | Baxter International Inc. | derivado de ácido graxo solúvel em água, e, métodos para preparar um derivado de ácido graxo e uma proteína terapêutica conjugada. |
| CA2836478A1 (en) | 2011-05-27 | 2012-12-06 | Baxter International Inc. | Therapeutic protein conjugated to water-soluble polymers via reduced cysteine sulfhydryl group |
| DK3412305T3 (da) * | 2011-06-10 | 2021-03-01 | Baxalta GmbH | Behandling af koagulationssygdom ved administration af rekombinant vwf |
| CN104271150A (zh) * | 2012-01-12 | 2015-01-07 | 比奥根艾迪克Ma公司 | 嵌合因子viii多肽及其用途 |
| MX369862B (es) | 2012-02-15 | 2019-11-25 | Bioverativ Therapeutics Inc | Composiciones del factor viii y metodos para hacerlas y usarlas. |
| ES2651523T3 (es) | 2012-02-15 | 2018-01-26 | Csl Behring Gmbh | Variantes del Factor de von Willebrand que tienen afinidad de unión al Factor VIII mejorada |
| NZ628014A (en) | 2012-02-15 | 2016-09-30 | Biogen Ma Inc | Recombinant factor viii proteins |
| AU2013204754C1 (en) | 2012-05-16 | 2018-10-11 | Takeda Pharmaceutical Company Limited | Nucleophilic Catalysts for Oxime Linkage |
| RS59876B1 (sr) * | 2012-07-11 | 2020-03-31 | Bioverativ Therapeutics Inc | Kompleks faktora viii sa xten i proteinom fon vilebrandovog faktora, i njihova primena |
| ES2657291T3 (es) * | 2013-04-22 | 2018-03-02 | Csl Ltd. | Un complejo covalente de factor de von Willebrand y factor VIII asociado por un puente disulfuro |
| WO2015021423A2 (en) * | 2013-08-08 | 2015-02-12 | Biogen Idec Ma Inc. | Purification of chimeric fviii molecules |
| EP3033097B1 (en) | 2013-08-14 | 2021-03-10 | Bioverativ Therapeutics Inc. | Factor viii-xten fusions and uses thereof |
| PT4176894T (pt) | 2014-01-10 | 2024-05-21 | Bioverativ Therapeutics Inc | Proteínas quiméricas de fator viii e utilizações destas |
| WO2015188224A1 (en) | 2014-06-13 | 2015-12-17 | Csl Limited | Improved production of recombinant von willebrand factor in a bioreactor |
| WO2016000039A1 (en) | 2014-07-02 | 2016-01-07 | Csl Limited | Modified von willebrand factor |
| CN104491917B (zh) * | 2014-12-30 | 2018-01-09 | 广州市拜特凇医药科技有限公司 | 一种含有peg或其衍生物的生物材料 |
| DK3265483T3 (da) | 2015-03-06 | 2020-03-02 | CSL Behring Lengnau AG | Modificeret von Willebrand-faktor med forbedret halveringstid |
| EP4089109A3 (en) | 2015-05-22 | 2023-03-01 | CSL Behring Lengnau AG | Methods for preparing modified von willebrand factor |
| EP3297656B1 (en) | 2015-05-22 | 2020-01-08 | CSL Behring Lengnau AG | Truncated von willebrand factor polypeptides for treating hemophilia |
| JP2015155469A (ja) * | 2015-06-01 | 2015-08-27 | バクスター・インターナショナル・インコーポレイテッドBaxter International Incorp0Rated | 第fviii因子ポリマー結合体 |
| CA2994547A1 (en) | 2015-08-03 | 2017-02-09 | Bioverativ Therapeutics Inc. | Factor ix fusion proteins and methods of making and using same |
| WO2017117630A1 (en) | 2016-01-07 | 2017-07-13 | Csl Limited | Mutated von willebrand factor |
| KR20180094114A (ko) | 2016-01-07 | 2018-08-22 | 체에스엘 베링 리컴비넌트 퍼실리티 아게 | 돌연변이된 절단된 폰 빌레브란트 인자 |
| TW201828975A (zh) | 2016-11-11 | 2018-08-16 | 瑞士商Csl貝林重組技能公司 | 用於治療血友病之截短型類血友病因子(von Willebrand factor)多肽類 |
| AU2017358865A1 (en) | 2016-11-11 | 2019-05-09 | CSL Behring Lengnau AG | Truncated von willebrand factor polypeptides for extravascular administration in the treatment or prophylaxis of a blood coagulation disorder |
| WO2018102743A1 (en) | 2016-12-02 | 2018-06-07 | Bioverativ Therapeutics Inc. | Methods of treating hemophilic arthropathy using chimeric clotting factors |
| JP7307047B2 (ja) | 2017-07-07 | 2023-07-11 | 武田薬品工業株式会社 | 組換えvwfの投与による重度のフォンヴィレブランド病を患う患者における消化管出血の治療 |
| US20190091298A1 (en) | 2017-07-07 | 2019-03-28 | Baxalta Incorporated | Treatment of patients with severe von willebrand disease undergoing elective surgery by administration of recombinant vwf |
| KR20200038309A (ko) | 2017-08-23 | 2020-04-10 | 체에스엘 베링 게엠베하 | 폰 빌레브란트 인자의 바이러스 여과 방법 |
| JP2018115170A (ja) * | 2018-03-02 | 2018-07-26 | バクスアルタ ゲーエムベーハー | 第fviii因子ポリマー結合体 |
| SG11202009213TA (en) | 2018-03-21 | 2020-10-29 | Baxalta Inc | Separation of vwf and vwf propeptide by chromatographic methods |
| SG11202010767SA (en) | 2018-05-18 | 2020-11-27 | Bioverativ Therapeutics Inc | Methods of treating hemophilia a |
| JP2022524291A (ja) | 2019-02-01 | 2022-05-02 | 武田薬品工業株式会社 | 組換えVWF(rVWF)を使用する予防治療法 |
| EP4028046B1 (en) | 2019-09-11 | 2024-02-14 | Takeda Pharmaceutical Company Limited | Methods of treatment related to complexes of von willebrand factor and complement c1q |
| JP2023514541A (ja) | 2020-02-04 | 2023-04-06 | 武田薬品工業株式会社 | 組換えvwfの投与による重症のフォンヴィレブランド病患者における過多月経の治療 |
Family Cites Families (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2004A (en) * | 1841-03-12 | Improvement in the manner of constructing and propelling steam-vessels | ||
| US4179337A (en) * | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| US4356170A (en) | 1981-05-27 | 1982-10-26 | Canadian Patents & Development Ltd. | Immunogenic polysaccharide-protein conjugates |
| JPS59172425A (ja) * | 1983-03-18 | 1984-09-29 | Nippon Chemiphar Co Ltd | 新規な血液凝固因子誘導体およびその製造法ならびにそれを含有する血液凝固促進剤 |
| US4757006A (en) | 1983-10-28 | 1988-07-12 | Genetics Institute, Inc. | Human factor VIII:C gene and recombinant methods for production |
| US4965199A (en) | 1984-04-20 | 1990-10-23 | Genentech, Inc. | Preparation of functional human factor VIII in mammalian cells using methotrexate based selection |
| US4970300A (en) | 1985-02-01 | 1990-11-13 | New York University | Modified factor VIII |
| JPS62502589A (ja) | 1985-04-11 | 1987-10-08 | ザ・チヤイルドレンズ・メデイカル・センタ−・コ−ポレ−シヨン | フオン・ビルブラント因子 |
| CA1339946C (en) | 1987-03-31 | 1998-07-07 | Michael J. Griffith | Ultrapurification process for polypeptides |
| US5605884A (en) | 1987-10-29 | 1997-02-25 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Factor VIII formulations in high ionic strength media |
| US4877608A (en) | 1987-11-09 | 1989-10-31 | Rorer Pharmaceutical Corporation | Pharmaceutical plasma protein formulations in low ionic strength media |
| US5122614A (en) * | 1989-04-19 | 1992-06-16 | Enzon, Inc. | Active carbonates of polyalkylene oxides for modification of polypeptides |
| DE4001451A1 (de) | 1990-01-19 | 1991-08-01 | Octapharma Ag | Stabile injizierbare loesungen von faktor viii und faktor ix |
| US5595732A (en) | 1991-03-25 | 1997-01-21 | Hoffmann-La Roche Inc. | Polyethylene-protein conjugates |
| DE4111393A1 (de) | 1991-04-09 | 1992-10-15 | Behringwerke Ag | Stabilisierte faktor viii-praeparationen |
| US5846951A (en) | 1991-06-06 | 1998-12-08 | The School Of Pharmacy, University Of London | Pharmaceutical compositions |
| WO1993000357A1 (en) * | 1991-06-28 | 1993-01-07 | Rhone-Poulenc Rorer International (Holdings) Inc. | Therapeutic polypeptides based on von willebrand factor |
| US6037452A (en) * | 1992-04-10 | 2000-03-14 | Alpha Therapeutic Corporation | Poly(alkylene oxide)-Factor VIII or Factor IX conjugate |
| SK282483B6 (sk) | 1992-10-02 | 2002-02-05 | Genetics Institute, Inc. | Stabilná kompozícia koagulačného faktora VIII, spôsob jej prípravy a stabilizácie |
| US5298643A (en) * | 1992-12-22 | 1994-03-29 | Enzon, Inc. | Aryl imidate activated polyalkylene oxides |
| WO1994015625A1 (en) | 1993-01-15 | 1994-07-21 | Enzon, Inc. | Factor viii - polymeric conjugates |
| US5621039A (en) | 1993-06-08 | 1997-04-15 | Hallahan; Terrence W. | Factor IX- polymeric conjugates |
| US5919455A (en) | 1993-10-27 | 1999-07-06 | Enzon, Inc. | Non-antigenic branched polymer conjugates |
| DE4435485C1 (de) | 1994-10-04 | 1996-03-21 | Immuno Ag | Verfahren zur Gewinnung von hochreinem von Willebrand-Faktor |
| US6127153A (en) | 1995-06-07 | 2000-10-03 | Neose Technologies, Inc. | Method of transferring at least two saccharide units with a polyglycosyltransferase, a polyglycosyltransferase and gene encoding a polyglycosyltransferase |
| SE9503380D0 (sv) | 1995-09-29 | 1995-09-29 | Pharmacia Ab | Protein derivatives |
| US6005077A (en) | 1995-11-10 | 1999-12-21 | Immuno Aktiengesellschaft | Use of von willebrand factor and pharmaceutical formulation |
| US6562781B1 (en) | 1995-11-30 | 2003-05-13 | Hamilton Civic Hospitals Research Development Inc. | Glycosaminoglycan-antithrombin III/heparin cofactor II conjugates |
| US5763401A (en) | 1996-07-12 | 1998-06-09 | Bayer Corporation | Stabilized albumin-free recombinant factor VIII preparation having a low sugar content |
| US6214966B1 (en) | 1996-09-26 | 2001-04-10 | Shearwater Corporation | Soluble, degradable poly(ethylene glycol) derivatives for controllable release of bound molecules into solution |
| AT405740B (de) | 1996-12-13 | 1999-11-25 | Immuno Ag | Von willebrand-faktor-derivat sowie ein verfahren zur isolierung von proteinen |
| AT405403B (de) | 1997-02-27 | 1999-08-25 | Immuno Ag | Reinigung von von willebrand-faktor durch kationenaustauscherchromatographie |
| AT405485B (de) | 1997-05-28 | 1999-08-25 | Immuno Ag | Eine das vwf-propeptid enthaltende pharmazeutische präparation |
| KR100358276B1 (ko) | 1998-03-24 | 2002-10-25 | 닛폰 유시 가부시키가이샤 | 옥시란 유도체 및 이의 제조방법 |
| AT407750B (de) | 1999-02-19 | 2001-05-25 | Immuno Ag | Verfahren zur herstellung einer vwf-präparation |
| DK1820516T3 (da) | 1999-02-22 | 2013-10-28 | Univ Connecticut | Nye albuminfrie faktor VIII-præparater |
| AU6357900A (en) * | 1999-07-20 | 2001-02-05 | Amgen, Inc. | Hyaluronic acid-protein conjugates, pharmaceutical compositions and related methods |
| SE515295C2 (sv) * | 1999-11-23 | 2001-07-09 | Medicarb Ab | Förfarande för framställning av konjugat av en biologiskt aktiv polysackarid och ett fast substrat, samt sådana konjugat |
| AUPR610501A0 (en) | 2001-07-04 | 2001-07-26 | Smart Drug Systems Inc | Treatment of parasitic disease |
| US7265084B2 (en) | 2001-10-10 | 2007-09-04 | Neose Technologies, Inc. | Glycopegylation methods and proteins/peptides produced by the methods |
| AU2002352524B2 (en) | 2001-11-07 | 2007-10-04 | Nektar Therapeutics | Branched polymers and their conjugates |
| WO2004075923A2 (en) * | 2003-02-26 | 2004-09-10 | Nektar Therapeutics Al, Corporation | Polymer-factor viii moiety conjugates |
| US20050176108A1 (en) * | 2003-03-13 | 2005-08-11 | Young-Min Kim | Physiologically active polypeptide conjugate having prolonged in vivo half-life |
| US20040247624A1 (en) * | 2003-06-05 | 2004-12-09 | Unger Evan Charles | Methods of making pharmaceutical formulations for the delivery of drugs having low aqueous solubility |
| WO2005032581A2 (en) * | 2003-10-07 | 2005-04-14 | Novo Nordisk Health Care Ag | Hybrid molecules having factor vii/viia activity |
| EP1691841B1 (en) * | 2003-12-10 | 2020-09-09 | Nektar Therapeutics | Compositions comprising two different populations of polymer-active agent conjugates |
| DK1835938T3 (da) | 2004-12-27 | 2013-11-04 | Baxter Int | Polymer-von Willebrand-faktor-konjugater |
-
2005
- 2005-12-23 DK DK05855442.9T patent/DK1835938T3/da active
- 2005-12-23 WO PCT/US2005/046879 patent/WO2006071801A2/en not_active Ceased
- 2005-12-23 BR BRPI0519562-4A patent/BRPI0519562A2/pt not_active IP Right Cessation
- 2005-12-23 KR KR1020077017261A patent/KR20070092754A/ko not_active Withdrawn
- 2005-12-23 ES ES05855442T patent/ES2434035T3/es not_active Expired - Lifetime
- 2005-12-23 MX MX2007007877A patent/MX2007007877A/es active IP Right Grant
- 2005-12-23 US US11/317,582 patent/US7884075B2/en active Active
- 2005-12-23 EP EP05855442.9A patent/EP1835938B1/en not_active Expired - Lifetime
- 2005-12-23 CA CA002591852A patent/CA2591852A1/en not_active Abandoned
- 2005-12-23 PL PL05855442T patent/PL1835938T3/pl unknown
- 2005-12-23 JP JP2007548552A patent/JP5022231B2/ja not_active Expired - Lifetime
- 2005-12-23 CN CN2005800445983A patent/CN101163506B/zh not_active Expired - Lifetime
- 2005-12-23 PT PT58554429T patent/PT1835938E/pt unknown
- 2005-12-23 AU AU2005322067A patent/AU2005322067B8/en active Active
-
2007
- 2007-06-04 IL IL183634A patent/IL183634A/en active IP Right Grant
-
2011
- 2011-01-14 US US13/007,208 patent/US8076463B2/en not_active Expired - Lifetime
- 2011-11-28 US US13/305,334 patent/US8357779B2/en not_active Expired - Lifetime
-
2012
- 2012-03-30 JP JP2012081700A patent/JP5715983B2/ja not_active Expired - Lifetime
- 2012-12-21 US US13/724,831 patent/US8835388B2/en not_active Expired - Lifetime
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