DK1835938T3 - Polymer-von Willebrand-faktor-konjugater - Google Patents
Polymer-von Willebrand-faktor-konjugaterInfo
- Publication number
- DK1835938T3 DK1835938T3 DK05855442.9T DK05855442T DK1835938T3 DK 1835938 T3 DK1835938 T3 DK 1835938T3 DK 05855442 T DK05855442 T DK 05855442T DK 1835938 T3 DK1835938 T3 DK 1835938T3
- Authority
- DK
- Denmark
- Prior art keywords
- polymer
- von willebrand
- willebrand factor
- factor conjugates
- conjugates
- Prior art date
Links
- 229960001134 von willebrand factor Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/775—Apolipopeptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63924404P | 2004-12-27 | 2004-12-27 | |
| US66837805P | 2005-04-04 | 2005-04-04 | |
| US67190105P | 2005-04-15 | 2005-04-15 | |
| US68508605P | 2005-05-26 | 2005-05-26 | |
| PCT/US2005/046879 WO2006071801A2 (en) | 2004-12-27 | 2005-12-23 | Polymer-von willebrand factor-conjugates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1835938T3 true DK1835938T3 (da) | 2013-11-04 |
Family
ID=36540284
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK05855442.9T DK1835938T3 (da) | 2004-12-27 | 2005-12-23 | Polymer-von Willebrand-faktor-konjugater |
Country Status (15)
| Country | Link |
|---|---|
| US (4) | US7884075B2 (enExample) |
| EP (1) | EP1835938B1 (enExample) |
| JP (2) | JP5022231B2 (enExample) |
| KR (1) | KR20070092754A (enExample) |
| CN (1) | CN101163506B (enExample) |
| AU (1) | AU2005322067B8 (enExample) |
| BR (1) | BRPI0519562A2 (enExample) |
| CA (1) | CA2591852A1 (enExample) |
| DK (1) | DK1835938T3 (enExample) |
| ES (1) | ES2434035T3 (enExample) |
| IL (1) | IL183634A (enExample) |
| MX (1) | MX2007007877A (enExample) |
| PL (1) | PL1835938T3 (enExample) |
| PT (1) | PT1835938E (enExample) |
| WO (1) | WO2006071801A2 (enExample) |
Families Citing this family (74)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6263355A (ja) * | 1985-09-13 | 1987-03-20 | Hitachi Ltd | バツテリバツクアツプｒａｍのチエツク方法 |
| AU2005322067B8 (en) | 2004-12-27 | 2012-07-26 | Takeda Pharmaceutical Company Limited | Polymer-von Willebrand factor-conjugates |
| US7985839B2 (en) | 2006-03-31 | 2011-07-26 | Baxter International Inc. | Factor VIII polymer conjugates |
| US7982010B2 (en) | 2006-03-31 | 2011-07-19 | Baxter International Inc. | Factor VIII polymer conjugates |
| CA2647314A1 (en) | 2006-03-31 | 2007-11-08 | Baxter International Inc. | Pegylated factor viii |
| US7645860B2 (en) * | 2006-03-31 | 2010-01-12 | Baxter Healthcare S.A. | Factor VIII polymer conjugates |
| JP5570809B2 (ja) | 2006-09-01 | 2014-08-13 | ノボ ノルディスク ヘルス ケア アーゲー | 修飾タンパク質 |
| EP2101821B1 (en) * | 2006-12-15 | 2014-08-13 | Baxter International Inc. | Factor viia- (poly) sialic acid conjugate having prolonged in vivo half-life |
| US8133865B2 (en) * | 2006-12-27 | 2012-03-13 | Nektar Therapeutics | von Willebrand factor- and factor VIII-polymer conjugates having a releasable linkage |
| PL2152735T3 (pl) * | 2007-05-18 | 2015-08-31 | Baxalta Inc | Sposób wytwarzania dojrzałego VWF z propeptydu |
| ES2392569T3 (es) * | 2007-06-13 | 2012-12-11 | Csl Behring Gmbh | Uso de preparaciones FVIII estabilizadas VWF para administración extravascular en la terapia y el tratamiento profiláctico de trastornos de hemorragias |
| MX2009013682A (es) | 2007-06-26 | 2010-08-31 | Baxter Int | Enlazador de fmoc polimerico hidrolizable. |
| EP2222329A1 (en) * | 2007-11-09 | 2010-09-01 | Baxter International Inc. | Modified recombinant factor viii and von willebrand factor and methods of use |
| KR101627157B1 (ko) | 2007-12-27 | 2016-06-03 | 박스알타 인코퍼레이티드 | 샘플 내의 재조합 단백질로부터 혈장-유래 단백질의 분별 방법 |
| ES2428774T3 (es) | 2007-12-27 | 2013-11-11 | Baxter International Inc. | Procedimiento y composiciones para detectar específicamente moléculas poliméricas fisiológicamente aceptables |
| US11197916B2 (en) | 2007-12-28 | 2021-12-14 | Takeda Pharmaceutical Company Limited | Lyophilized recombinant VWF formulations |
| MX2010007150A (es) * | 2007-12-28 | 2010-09-03 | Baxter Int | Formulaciones del factor de von-willebrand recombinante. |
| EP2235188A2 (en) * | 2007-12-31 | 2010-10-06 | Baxter International Inc. | Transgenic non-human animals expressing human blood clotting factors |
| CN102083469A (zh) * | 2008-05-06 | 2011-06-01 | 奥克塔法马股份有限公司 | 含有肝素结合蛋白和肝素-羟烷基淀粉缀合物的复合物 |
| ES2531464T3 (es) * | 2008-06-24 | 2015-03-16 | Csl Behring Gmbh | Factor VIII, factor de von Willebrand o sus complejos con semivida in vivo prolongada |
| AR072596A1 (es) * | 2008-07-23 | 2010-09-08 | Hanmi Pharmaceutical Co Ltd | Un complejo proteico que comprende una proteina dimerica y un polimero no peptidico |
| US8575102B2 (en) * | 2008-08-01 | 2013-11-05 | Nektar Therapeutics | Conjugates having a releasable linkage |
| CA2738679A1 (en) | 2008-10-17 | 2010-04-22 | Baxter International Inc. | Modified blood factors comprising a low degree of water soluble polymer |
| EP2337794B1 (en) * | 2008-10-20 | 2013-07-31 | USV Limited | An improved process for pegylation of proteins |
| KR101772674B1 (ko) * | 2008-10-21 | 2017-09-01 | 박스알타 인코퍼레이티드 | 동결건조된 재조합 ｖｗｆ 제제 |
| EP2350658A2 (en) | 2008-10-21 | 2011-08-03 | Baxter International Inc. | Methods for determining active ingredients in pro-drug peg protein conjugates with releasable peg reagents (in vitro de-pegylation) |
| US20100152115A1 (en) * | 2008-12-11 | 2010-06-17 | Baxter International Inc. | Detection of physiologically acceptable polymer molecules using near infrared spectroscopy |
| PL2459224T3 (pl) | 2009-07-27 | 2017-08-31 | Baxalta GmbH | Koniugaty białka związanego z krzepnięciem krwi |
| EP2459226B1 (en) | 2009-07-27 | 2016-06-29 | Lipoxen Technologies Limited | Glycopolysialylation of proteins other than blood coagulation proteins |
| US8642737B2 (en) | 2010-07-26 | 2014-02-04 | Baxter International Inc. | Nucleophilic catalysts for oxime linkage |
| US8809501B2 (en) | 2009-07-27 | 2014-08-19 | Baxter International Inc. | Nucleophilic catalysts for oxime linkage |
| TWI537006B (zh) | 2009-07-27 | 2016-06-11 | 巴克斯歐塔公司 | 凝血蛋白接合物 |
| WO2011017414A2 (en) | 2009-08-04 | 2011-02-10 | Baxter International Inc. | Transgenic mouse lacking endogenous fviii and vwf - a model of hemophilia a |
| IN2012DN01849A (enExample) | 2009-08-20 | 2015-08-21 | Baxter Int | |
| AU2010290131C1 (en) | 2009-08-24 | 2015-12-03 | Amunix Operating Inc. | Coagulation factor VII compositions and methods of making and using same |
| NZ600278A (en) * | 2009-11-13 | 2014-04-30 | Grifols Therapeutics Inc | Von willebrand factor (vwf)-containing preparations, and methods, kits, and uses related thereto |
| GB201007357D0 (en) * | 2010-04-30 | 2010-06-16 | Leverton Licence Holdings Ltd | Conjugated factor VIII |
| AR082941A1 (es) | 2010-07-30 | 2013-01-23 | Baxter Int | Metodo para conjugar un polimero hidrosoluble a una porcion de carbohidrato oxidado de una proteina terapeutica |
| KR101309566B1 (ko) | 2010-12-10 | 2013-09-17 | 포항공과대학교 산학협력단 | 히알루론산-단백질 컨쥬게이트 및 이의 제조 방법 |
| PT2654794T (pt) | 2010-12-22 | 2020-06-11 | Baxalta Inc | Materiais e métodos para conjugação de um derivado de ácido gordo solúvel em água a uma proteína |
| JP2014520094A (ja) | 2011-05-27 | 2014-08-21 | バクスター・インターナショナル・インコーポレイテッド | 増加した半減期を有する治療用タンパク質およびそれを調製する方法 |
| KR20190041032A (ko) * | 2011-06-10 | 2019-04-19 | 박스알타 인코퍼레이티드 | 재조합 vwf의 투여에 의한 응고 질환의 치료 |
| NZ626945A (en) | 2012-01-12 | 2016-10-28 | Biogen Ma Inc | Chimeric factor viii polypeptides and uses thereof |
| DK3564260T5 (da) | 2012-02-15 | 2024-09-02 | Bioverativ Therapeutics Inc | Faktor viii-sammensætninger og fremgangsmåder til fremstilling og anvendelse deraf |
| WO2013120939A1 (en) | 2012-02-15 | 2013-08-22 | Csl Behring Gmbh | Von willebrand factor variants having improved factor viii binding affinity |
| EP2822577B1 (en) | 2012-02-15 | 2019-02-06 | Bioverativ Therapeutics Inc. | Recombinant factor viii proteins |
| AU2013204754C1 (en) | 2012-05-16 | 2018-10-11 | Takeda Pharmaceutical Company Limited | Nucleophilic Catalysts for Oxime Linkage |
| US10138291B2 (en) * | 2012-07-11 | 2018-11-27 | Bioverativ Therapeutics Inc. | Factor VIII complex with XTEN and von Willebrand Factor protein, and uses thereof |
| DK2796145T3 (da) | 2013-04-22 | 2018-01-29 | Csl Ltd | Et kovalent kompleks af von Willebrand-faktor og faktor VIII linket af en disulfidbro |
| WO2015021423A2 (en) * | 2013-08-08 | 2015-02-12 | Biogen Idec Ma Inc. | Purification of chimeric fviii molecules |
| WO2015023891A2 (en) | 2013-08-14 | 2015-02-19 | Biogen Idec Ma Inc. | Factor viii-xten fusions and uses thereof |
| SG10201913697UA (en) * | 2014-01-10 | 2020-03-30 | Bioverativ Therapeutics Inc | Factor viii chimeric proteins and uses thereof |
| DK3158055T3 (da) | 2014-06-13 | 2019-10-14 | Csl Ltd | Forbedret produktion af recombinant von willebrand-faktor i en bioreaktor |
| EP3164150B1 (en) | 2014-07-02 | 2020-11-04 | CSL Behring Lengnau AG | Modified von willebrand factor |
| CN104491917B (zh) * | 2014-12-30 | 2018-01-09 | 广州市拜特凇医药科技有限公司 | 一种含有peg或其衍生物的生物材料 |
| CN107406493B (zh) | 2015-03-06 | 2021-08-13 | 康诺贝林伦瑙有限公司 | 具有改善的半衰期的经修饰的血管性血友病因子 |
| CN107810194B (zh) | 2015-05-22 | 2021-10-08 | 康诺贝林伦瑙有限公司 | 用于制备经修饰的血管性血友病因子的方法 |
| SG11201708755WA (en) | 2015-05-22 | 2017-12-28 | Csl Behring Recombinant Facility Ag | Truncated von willebrand factor polypeptides for treating hemophilia |
| JP2015155469A (ja) * | 2015-06-01 | 2015-08-27 | バクスター・インターナショナル・インコーポレイテッドＢａｘｔｅｒ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｉｎｃｏｒｐ０Ｒａｔｅｄ | 第ｆｖｉｉｉ因子ポリマー結合体 |
| CA2994547A1 (en) | 2015-08-03 | 2017-02-09 | Bioverativ Therapeutics Inc. | Factor ix fusion proteins and methods of making and using same |
| BR112018013822A2 (pt) | 2016-01-07 | 2018-12-11 | Csl Behring Recombinant Facility Ag | ?polipeptídeo modificado, complexo, composição farmacêutica, métodos para tratamento de um distúrbio hemorrágico, para produção de um polipeptídeo e para aumento da meia-vida do fator viii, uso de um polipeptídeo modificado, polinucleotídeo, plasmídeo ou vetor, e, célula hospedeira? |
| US10806774B2 (en) | 2016-01-07 | 2020-10-20 | CSL Behring Lengnau AG | Mutated truncated von Willebrand Factor |
| CA3043397A1 (en) | 2016-11-11 | 2018-05-17 | CSL Behring Lengnau AG | Truncated von willebrand factor polypeptides for extravascular administration in the treatment or prophylaxis of a blood coagulation disorder |
| EP3538133B1 (en) | 2016-11-11 | 2021-02-17 | CSL Behring Lengnau AG | Truncated von willebrand factor polypeptides for treating hemophilia |
| MX2019006444A (es) | 2016-12-02 | 2019-10-30 | Bioverativ Therapeutics Inc | Métodos de tratamiento de artropatía hemofílica utilizando factores de coagulación quiméricos. |
| EP4424366A3 (en) | 2017-07-07 | 2024-12-04 | Takeda Pharmaceutical Company Limited | Treatment of gastrointestinal bleeding in patients with severe von willebrand disease by administration of recombinant vwf |
| RU2766118C2 (ru) | 2017-07-07 | 2022-02-08 | Такеда Фармасьютикал Компани Лимитед | Лечение пациентов с тяжелой формой болезни фон виллебранда, подвергающихся плановому хирургическому вмешательству, путем введения рекомбинантного ффв |
| KR20250088663A (ko) | 2017-08-23 | 2025-06-17 | 체에스엘 베링 게엠베하 | 폰 빌레브란트 인자의 바이러스 여과 방법 |
| JP2018115170A (ja) * | 2018-03-02 | 2018-07-26 | バクスアルタ ゲーエムベーハー | 第ｆｖｉｉｉ因子ポリマー結合体 |
| EP3768697A1 (en) | 2018-03-21 | 2021-01-27 | Baxalta Incorporated | Separation of vwf and vwf propeptide by chromatographic methods |
| CN112512555A (zh) | 2018-05-18 | 2021-03-16 | 比奥维拉迪维治疗股份有限公司 | 治疗血友病a的方法 |
| MX2021009114A (es) | 2019-02-01 | 2021-10-13 | Takeda Pharmaceuticals Co | Métodos de tratamiento profiláctico que usan factor de von willebrand recombinante (rvwf). |
| JP2022547556A (ja) | 2019-09-11 | 2022-11-14 | 武田薬品工業株式会社 | フォン・ヴィレブランド因子と補体ｃ１ｑの複合体に関連する治療法 |
| CN115335074A (zh) | 2020-02-04 | 2022-11-11 | 武田药品工业株式会社 | 通过施用重组vwf来治疗患有重度冯维勒布兰德病的患者的月经过多 |
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-
2005
- 2005-12-23 AU AU2005322067A patent/AU2005322067B8/en not_active Expired
- 2005-12-23 CN CN2005800445983A patent/CN101163506B/zh not_active Expired - Lifetime
- 2005-12-23 PL PL05855442T patent/PL1835938T3/pl unknown
- 2005-12-23 CA CA002591852A patent/CA2591852A1/en not_active Abandoned
- 2005-12-23 PT PT58554429T patent/PT1835938E/pt unknown
- 2005-12-23 JP JP2007548552A patent/JP5022231B2/ja not_active Expired - Lifetime
- 2005-12-23 EP EP05855442.9A patent/EP1835938B1/en not_active Expired - Lifetime
- 2005-12-23 DK DK05855442.9T patent/DK1835938T3/da active
- 2005-12-23 ES ES05855442T patent/ES2434035T3/es not_active Expired - Lifetime
- 2005-12-23 KR KR1020077017261A patent/KR20070092754A/ko not_active Withdrawn
- 2005-12-23 MX MX2007007877A patent/MX2007007877A/es active IP Right Grant
- 2005-12-23 US US11/317,582 patent/US7884075B2/en active Active
- 2005-12-23 WO PCT/US2005/046879 patent/WO2006071801A2/en not_active Ceased
- 2005-12-23 BR BRPI0519562-4A patent/BRPI0519562A2/pt not_active IP Right Cessation
-
2007
- 2007-06-04 IL IL183634A patent/IL183634A/en active IP Right Grant
-
2011
- 2011-01-14 US US13/007,208 patent/US8076463B2/en not_active Expired - Lifetime
- 2011-11-28 US US13/305,334 patent/US8357779B2/en not_active Expired - Lifetime
-
2012
- 2012-03-30 JP JP2012081700A patent/JP5715983B2/ja not_active Expired - Lifetime
- 2012-12-21 US US13/724,831 patent/US8835388B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US7884075B2 (en) | 2011-02-08 |
| WO2006071801A3 (en) | 2007-08-16 |
| IL183634A0 (en) | 2007-09-20 |
| MX2007007877A (es) | 2007-08-21 |
| JP5715983B2 (ja) | 2015-05-13 |
| PL1835938T3 (pl) | 2014-01-31 |
| BRPI0519562A2 (pt) | 2009-01-27 |
| EP1835938B1 (en) | 2013-08-07 |
| US8076463B2 (en) | 2011-12-13 |
| US20060160948A1 (en) | 2006-07-20 |
| CN101163506B (zh) | 2012-09-26 |
| EP1835938A2 (en) | 2007-09-26 |
| JP2012126750A (ja) | 2012-07-05 |
| ES2434035T3 (es) | 2013-12-13 |
| JP5022231B2 (ja) | 2012-09-12 |
| AU2005322067B8 (en) | 2012-07-26 |
| US20130190242A1 (en) | 2013-07-25 |
| CN101163506A (zh) | 2008-04-16 |
| JP2008525491A (ja) | 2008-07-17 |
| HK1105276A1 (en) | 2008-02-06 |
| PT1835938E (pt) | 2013-11-06 |
| AU2005322067B2 (en) | 2012-07-05 |
| US20110111455A1 (en) | 2011-05-12 |
| AU2005322067A1 (en) | 2006-07-06 |
| CA2591852A1 (en) | 2006-07-06 |
| US20120135462A1 (en) | 2012-05-31 |
| IL183634A (en) | 2012-02-29 |
| WO2006071801A2 (en) | 2006-07-06 |
| KR20070092754A (ko) | 2007-09-13 |
| US8357779B2 (en) | 2013-01-22 |
| US8835388B2 (en) | 2014-09-16 |
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