JP5022231B2 - ポリマー−フォンビルブラント因子結合体 - Google Patents

ポリマー−フォンビルブラント因子結合体 Download PDF

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Publication number
JP5022231B2
JP5022231B2 JP2007548552A JP2007548552A JP5022231B2 JP 5022231 B2 JP5022231 B2 JP 5022231B2 JP 2007548552 A JP2007548552 A JP 2007548552A JP 2007548552 A JP2007548552 A JP 2007548552A JP 5022231 B2 JP5022231 B2 JP 5022231B2
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vwf
fviii
molecule
life
rvwf
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Expired - Lifetime
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Japanese (ja)
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JP2008525491A5 (enExample
JP2008525491A (ja
Inventor
フリードリッヒ シャイフリンガー，
ペーター トゥレセク，
ヨーガン シークマン，
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Baxter Healthcare SA
Baxter International Inc
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Baxter Healthcare SA
Baxter International Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/775—Apolipopeptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2007548552A 2004-12-27 2005-12-23 ポリマー−フォンビルブラント因子結合体 Expired - Lifetime JP5022231B2 (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US63924404P 2004-12-27 2004-12-27
US60/639,244 2004-12-27
US66837805P 2005-04-04 2005-04-04
US60/668,378 2005-04-04
US67190105P 2005-04-15 2005-04-15
US60/671,901 2005-04-15
US68508605P 2005-05-26 2005-05-26
US60/685,086 2005-05-26
PCT/US2005/046879 WO2006071801A2 (en) 2004-12-27 2005-12-23 Polymer-von willebrand factor-conjugates

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2012081700A Division JP5715983B2 (ja) 2004-12-27 2012-03-30 ポリマー−フォンビルブラント因子結合体

Publications (3)

Publication Number Publication Date
JP2008525491A JP2008525491A (ja) 2008-07-17
JP2008525491A5 JP2008525491A5 (enExample) 2009-02-12
JP5022231B2 true JP5022231B2 (ja) 2012-09-12

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JP2007548552A Expired - Lifetime JP5022231B2 (ja) 2004-12-27 2005-12-23 ポリマー−フォンビルブラント因子結合体
JP2012081700A Expired - Lifetime JP5715983B2 (ja) 2004-12-27 2012-03-30 ポリマー−フォンビルブラント因子結合体

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US (4) US7884075B2 (enExample)
EP (1) EP1835938B1 (enExample)
JP (2) JP5022231B2 (enExample)
KR (1) KR20070092754A (enExample)
CN (1) CN101163506B (enExample)
AU (1) AU2005322067B8 (enExample)
BR (1) BRPI0519562A2 (enExample)
CA (1) CA2591852A1 (enExample)
DK (1) DK1835938T3 (enExample)
ES (1) ES2434035T3 (enExample)
IL (1) IL183634A (enExample)
MX (1) MX2007007877A (enExample)
PL (1) PL1835938T3 (enExample)
PT (1) PT1835938E (enExample)
WO (1) WO2006071801A2 (enExample)

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JP2012126750A (ja) 2012-07-05
WO2006071801A3 (en) 2007-08-16
US8076463B2 (en) 2011-12-13
AU2005322067B8 (en) 2012-07-26
AU2005322067A1 (en) 2006-07-06
US20060160948A1 (en) 2006-07-20
US20110111455A1 (en) 2011-05-12
HK1105276A1 (en) 2008-02-06
US20120135462A1 (en) 2012-05-31
BRPI0519562A2 (pt) 2009-01-27
CN101163506B (zh) 2012-09-26
PT1835938E (pt) 2013-11-06
US20130190242A1 (en) 2013-07-25
EP1835938A2 (en) 2007-09-26
JP2008525491A (ja) 2008-07-17
WO2006071801A2 (en) 2006-07-06
KR20070092754A (ko) 2007-09-13
CA2591852A1 (en) 2006-07-06
EP1835938B1 (en) 2013-08-07
JP5715983B2 (ja) 2015-05-13
DK1835938T3 (da) 2013-11-04
AU2005322067B2 (en) 2012-07-05
PL1835938T3 (pl) 2014-01-31
IL183634A (en) 2012-02-29
US8357779B2 (en) 2013-01-22
US7884075B2 (en) 2011-02-08
CN101163506A (zh) 2008-04-16
IL183634A0 (en) 2007-09-20
ES2434035T3 (es) 2013-12-13
US8835388B2 (en) 2014-09-16

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