PL1835938T3 - Koniugaty polimer-czynnik von Willebrandta - Google Patents
Koniugaty polimer-czynnik von WillebrandtaInfo
- Publication number
- PL1835938T3 PL1835938T3 PL05855442T PL05855442T PL1835938T3 PL 1835938 T3 PL1835938 T3 PL 1835938T3 PL 05855442 T PL05855442 T PL 05855442T PL 05855442 T PL05855442 T PL 05855442T PL 1835938 T3 PL1835938 T3 PL 1835938T3
- Authority
- PL
- Poland
- Prior art keywords
- conjugates
- polymer
- von willebrand
- willebrand factor
- factor
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/775—Apolipopeptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63924404P | 2004-12-27 | 2004-12-27 | |
| US66837805P | 2005-04-04 | 2005-04-04 | |
| US67190105P | 2005-04-15 | 2005-04-15 | |
| US68508605P | 2005-05-26 | 2005-05-26 | |
| EP05855442.9A EP1835938B1 (en) | 2004-12-27 | 2005-12-23 | Polymer-von willebrand factor-conjugates |
| PCT/US2005/046879 WO2006071801A2 (en) | 2004-12-27 | 2005-12-23 | Polymer-von willebrand factor-conjugates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL1835938T3 true PL1835938T3 (pl) | 2014-01-31 |
Family
ID=36540284
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL05855442T PL1835938T3 (pl) | 2004-12-27 | 2005-12-23 | Koniugaty polimer-czynnik von Willebrandta |
Country Status (15)
| Country | Link |
|---|---|
| US (4) | US7884075B2 (enExample) |
| EP (1) | EP1835938B1 (enExample) |
| JP (2) | JP5022231B2 (enExample) |
| KR (1) | KR20070092754A (enExample) |
| CN (1) | CN101163506B (enExample) |
| AU (1) | AU2005322067B8 (enExample) |
| BR (1) | BRPI0519562A2 (enExample) |
| CA (1) | CA2591852A1 (enExample) |
| DK (1) | DK1835938T3 (enExample) |
| ES (1) | ES2434035T3 (enExample) |
| IL (1) | IL183634A (enExample) |
| MX (1) | MX2007007877A (enExample) |
| PL (1) | PL1835938T3 (enExample) |
| PT (1) | PT1835938E (enExample) |
| WO (1) | WO2006071801A2 (enExample) |
Families Citing this family (74)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6263355A (ja) * | 1985-09-13 | 1987-03-20 | Hitachi Ltd | バツテリバツクアツプｒａｍのチエツク方法 |
| AU2005322067B8 (en) * | 2004-12-27 | 2012-07-26 | Takeda Pharmaceutical Company Limited | Polymer-von Willebrand factor-conjugates |
| WO2007126808A1 (en) | 2006-03-31 | 2007-11-08 | Baxter International Inc | Pegylated factor viii |
| US7982010B2 (en) | 2006-03-31 | 2011-07-19 | Baxter International Inc. | Factor VIII polymer conjugates |
| US7985839B2 (en) | 2006-03-31 | 2011-07-26 | Baxter International Inc. | Factor VIII polymer conjugates |
| US7645860B2 (en) * | 2006-03-31 | 2010-01-12 | Baxter Healthcare S.A. | Factor VIII polymer conjugates |
| US20100056428A1 (en) | 2006-09-01 | 2010-03-04 | Novo Nordisk Health Care Ag | Modified proteins |
| DK2101821T3 (da) * | 2006-12-15 | 2014-10-06 | Baxter Healthcare Sa | Faktor VIIA-(poly)sialinsyre-konjugat med forlænget halveringstid in vivo |
| MX2009007145A (es) | 2006-12-27 | 2009-08-27 | Nektar Therapeutics Al Corp | Conjugados de polimero con factor viii y factor de von willebrand que tienen una ligadura liberable. |
| KR101156263B1 (ko) * | 2007-05-18 | 2012-06-13 | 박스터 헬쓰케어 에스.에이. | 폰 빌리브란트 인자 프로펩티드로부터 성숙한 폰 빌리브란트 인자를 제조하는 방법 |
| PL2167117T3 (pl) * | 2007-06-13 | 2013-01-31 | Csl Behring Gmbh | Zastosowanie stabilizowanego VWP preparatu FVIII do podawania pozanaczyniowego w terapii i profilaktyce zaburzeń krzepliwości krwi |
| TWI569810B (zh) | 2007-06-26 | 2017-02-11 | 巴克斯歐塔公司 | 可水解之聚合茀基甲氧基羰基－連接劑 |
| AU2008323768A1 (en) * | 2007-11-09 | 2009-05-14 | Baxter Healthcare S.A. | Modified recombinant Factor VIII and von Willebrand Factor and methods of use |
| KR101627157B1 (ko) * | 2007-12-27 | 2016-06-03 | 박스알타 인코퍼레이티드 | 샘플 내의 재조합 단백질로부터 혈장-유래 단백질의 분별 방법 |
| US8557534B2 (en) | 2007-12-27 | 2013-10-15 | Baxter International Inc. | Method and compositions for specifically detecting physiologically acceptable polymer molecules |
| US11197916B2 (en) | 2007-12-28 | 2021-12-14 | Takeda Pharmaceutical Company Limited | Lyophilized recombinant VWF formulations |
| EP2244814B1 (en) * | 2007-12-28 | 2021-06-02 | Takeda Pharmaceutical Company Limited | Recombinant vwf formulations |
| TWI492951B (zh) | 2007-12-31 | 2015-07-21 | Baxter Int | 表現人類凝血因子的基因轉殖非人類動物及其用途 |
| MX2010012044A (es) * | 2008-05-06 | 2011-05-19 | Octapharma Ag | Complejo que comprende proteinas de union a heparina y conjugados de heparina-almidon de hidroxialquilo. |
| EP2865760B1 (en) | 2008-06-24 | 2017-10-11 | CSL Behring GmbH | Factor viii, von willebrand factor or complexes thereof with prolonged in vivo half-life |
| EP2300501B1 (en) * | 2008-07-23 | 2014-08-20 | Hanmi Science Co., Ltd. | A polypeptide complex comprising non-peptidyl polymer having three functional ends |
| WO2010014258A2 (en) * | 2008-08-01 | 2010-02-04 | Nektar Therapeutics Al, Corporation | Conjugates having a releasable linkage |
| PT2349342T (pt) * | 2008-10-17 | 2018-10-26 | Baxalta Inc | Factores sanguíneos modificados que compreendem um baixo grau de polímero solúvel na água |
| MX2011004195A (es) * | 2008-10-20 | 2011-09-27 | Usv Ltd | Un proceso mejorado para la pegilacion de proteinas. |
| JP5775820B2 (ja) * | 2008-10-21 | 2015-09-09 | バクスター・インターナショナル・インコーポレイテッドＢａｘｔｅｒ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｉｎｃｏｒｐ０Ｒａｔｅｄ | 遊離可能ｐｅｇ試薬を有するプロドラッグｐｅｇタンパク質結合体において活性成分（インビトロ脱ペグ化）を決定する方法 |
| EP2349314B1 (en) | 2008-10-21 | 2013-02-27 | Baxter International Inc. | Lyophilized recombinant vwf formulations |
| JP5568091B2 (ja) * | 2008-12-11 | 2014-08-06 | バクスター・インターナショナル・インコーポレイテッド | 近赤外分光法を用いた生理学的に許容されるポリマー分子の検出 |
| US8642737B2 (en) | 2010-07-26 | 2014-02-04 | Baxter International Inc. | Nucleophilic catalysts for oxime linkage |
| BR112012001814A8 (pt) | 2009-07-27 | 2018-02-06 | Baxalta GmbH | Conjugados de proteína de coagulação sanguínea |
| RU2744370C2 (ru) | 2009-07-27 | 2021-03-05 | Баксалта Инкорпорейтед | Конъюгаты белков свертывания крови |
| EP3081233B1 (en) | 2009-07-27 | 2020-12-23 | Baxalta GmbH | Glycopolysialylation of proteins other than blood coagulation proteins |
| US8809501B2 (en) | 2009-07-27 | 2014-08-19 | Baxter International Inc. | Nucleophilic catalysts for oxime linkage |
| US20110072524A1 (en) * | 2009-08-04 | 2011-03-24 | Baxter International Inc. | Transgenic Mouse Lacking Endogenous FVIII and VWF - A Model of Hemophilia A |
| MX2012002129A (es) | 2009-08-20 | 2012-06-08 | Baxter Int | Purificacion del factor de von willebrand (vwf) para remocion incrementada de virus envueltos sin lipido. |
| CA2771999A1 (en) | 2009-08-24 | 2011-03-10 | Amunix Operating Inc. | Coagulation factor vii compositions and methods of making and using same |
| RU2579977C2 (ru) * | 2009-11-13 | 2016-04-10 | Грифольс Терапьютикс Инк. | СОДЕРЖАЩИЕ ФАКТОР ФОН ВИЛЛЕБРАНДА (vWF) ПРЕПАРАТЫ И СПОСОБЫ, НАБОРЫ И ПРИМЕНЕНИЯ, СВЯЗАННЫЕ С НИМИ |
| GB201007357D0 (en) * | 2010-04-30 | 2010-06-16 | Leverton Licence Holdings Ltd | Conjugated factor VIII |
| TWI534152B (zh) | 2010-07-30 | 2016-05-21 | 巴克斯特國際公司 | 用於肟連接的親核性催化劑 |
| KR101309566B1 (ko) * | 2010-12-10 | 2013-09-17 | 포항공과대학교 산학협력단 | 히알루론산-단백질 컨쥬게이트 및 이의 제조 방법 |
| ES2800983T3 (es) | 2010-12-22 | 2021-01-07 | Baxalta GmbH | Materiales y métodos para conjugar un derivado de ácido graso soluble en agua con una proteína |
| EP3412314A1 (en) | 2011-05-27 | 2018-12-12 | Baxalta GmbH | Therapeutic proteins conjugated to polysialic acid and methods of preparing same |
| CN103732244A (zh) * | 2011-06-10 | 2014-04-16 | 巴克斯特国际公司 | 通过施用重组vwf治疗凝血疾病 |
| HRP20191920T1 (hr) | 2012-01-12 | 2020-01-10 | Bioverativ Therapeutics Inc. | Kimerni polipeptidi faktora viii i njihova uporaba |
| US9458223B2 (en) | 2012-02-15 | 2016-10-04 | Csl Behring Gmbh | Von willebrand factor variants having improved factor VIII binding affinity |
| CN111548418A (zh) | 2012-02-15 | 2020-08-18 | 比奥贝拉蒂治疗公司 | 因子viii组合物及其制备和使用方法 |
| WO2013123457A1 (en) | 2012-02-15 | 2013-08-22 | Biogen Idec Ma Inc. | Recombinant factor viii proteins |
| AU2013204754C1 (en) | 2012-05-16 | 2018-10-11 | Takeda Pharmaceutical Company Limited | Nucleophilic Catalysts for Oxime Linkage |
| ES2770501T3 (es) * | 2012-07-11 | 2020-07-01 | Bioverativ Therapeutics Inc | Complejo del factor VIII con XTEN y proteína del factor de Von Willebrand y sus usos |
| EP2796145B1 (en) * | 2013-04-22 | 2017-11-01 | CSL Ltd. | A covalent complex of von willebrand factor and faktor viii linked by a disulphide bridge |
| EP3875106A1 (en) * | 2013-08-08 | 2021-09-08 | Bioverativ Therapeutics Inc. | Purification of chimeric fviii molecules |
| US10548953B2 (en) | 2013-08-14 | 2020-02-04 | Bioverativ Therapeutics Inc. | Factor VIII-XTEN fusions and uses thereof |
| EA201691111A1 (ru) | 2014-01-10 | 2017-01-30 | Байоджен Ма Инк. | Химерные белки фактора viii и их применение |
| EP3158055B1 (en) | 2014-06-13 | 2019-09-11 | CSL Limited | Improved production of recombinant von willebrand factor in a bioreactor |
| DK3164150T3 (da) | 2014-07-02 | 2021-02-08 | CSL Behring Lengnau AG | Modificeret von willebrand-faktor |
| CN104491917B (zh) * | 2014-12-30 | 2018-01-09 | 广州市拜特凇医药科技有限公司 | 一种含有peg或其衍生物的生物材料 |
| SG11201706659WA (en) | 2015-03-06 | 2017-09-28 | Csl Behring Recombinant Facility Ag | Modified von willebrand factor having improved half-life |
| CA2986626A1 (en) | 2015-05-22 | 2016-12-01 | Csl Behring Recombinant Facility Ag | Truncated von willebrand factor polypeptides for treating hemophilia |
| CA2986625A1 (en) | 2015-05-22 | 2016-12-01 | Csl Behring Recombinant Facility Ag | Methods for preparing modified von willebrand factor |
| JP2015155469A (ja) * | 2015-06-01 | 2015-08-27 | バクスター・インターナショナル・インコーポレイテッドＢａｘｔｅｒ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｉｎｃｏｒｐ０Ｒａｔｅｄ | 第ｆｖｉｉｉ因子ポリマー結合体 |
| UA126016C2 (uk) | 2015-08-03 | 2022-08-03 | Біовератів Терапеутікс Інк. | Злитий білок фактора іх |
| AU2017204955B2 (en) | 2016-01-07 | 2021-04-01 | CSL Behring Lengnau AG | Mutated truncated von Willebrand Factor |
| SG11201805494WA (en) | 2016-01-07 | 2018-07-30 | Csl Behring Recombinant Facility Ag | Mutated von willebrand factor |
| DK3538133T3 (da) | 2016-11-11 | 2021-04-19 | CSL Behring Lengnau AG | Trunkeret von willebrand faktor polypeptider til behandling af hæmofili |
| JP2020504082A (ja) | 2016-11-11 | 2020-02-06 | ツェー・エス・エル・ベーリング・レングナウ・アクチエンゲゼルシャフト | 血液凝固障害の処置又は予防における血管外投与のための切断型フォン・ヴィルブランド因子ポリペプチド |
| KR20190090827A (ko) | 2016-12-02 | 2019-08-02 | 바이오버라티브 테라퓨틱스 인크. | 키메라 응고 인자를 사용해 혈우병성 관절증을 치료하는 방법 |
| JP7326246B2 (ja) | 2017-07-07 | 2023-08-15 | 武田薬品工業株式会社 | 待機手術を受ける、重度のフォンヴィレブランド病を患う患者の、組換えｖｗｆの投与による治療法 |
| FI3648788T5 (fi) | 2017-07-07 | 2024-09-09 | Takeda Pharmaceuticals Co | Maha-suolikanavan verenvuodon hoito vaikeaa von willebrandin tautia sairastavilla potilailla antamalla rekombinanttia vwf:ää |
| EP3672644A1 (en) | 2017-08-23 | 2020-07-01 | CSL Behring GmbH | Method for virus filtration of von willebrand factor |
| JP2018115170A (ja) * | 2018-03-02 | 2018-07-26 | バクスアルタ ゲーエムベーハー | 第ｆｖｉｉｉ因子ポリマー結合体 |
| CA3094644A1 (en) | 2018-03-21 | 2019-09-26 | Baxalta Incorporated | Separation of vwf and vwf propeptide by chromatographic methods |
| KR102914074B1 (ko) | 2018-05-18 | 2026-01-16 | 바이오버라티브 테라퓨틱스 인크. | A형 혈우병의 치료 방법 |
| EA202192140A1 (ru) | 2019-02-01 | 2021-12-15 | Такеда Фармасьютикал Компани Лимитед | СПОСОБЫ ПРОФИЛАКТИЧЕСКОГО ЛЕЧЕНИЯ РЕКОМБИНАНТНЫМ ФВ (рФВ) |
| JP2022547556A (ja) | 2019-09-11 | 2022-11-14 | 武田薬品工業株式会社 | フォン・ヴィレブランド因子と補体ｃ１ｑの複合体に関連する治療法 |
| CA3169996A1 (en) | 2020-02-04 | 2021-08-12 | Takeda Pharmaceutical Company Limited | Treatment of menorrhagia in patients with severe von willebrand disease by administration of recombinant vwf |
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| US5846951A (en) * | 1991-06-06 | 1998-12-08 | The School Of Pharmacy, University Of London | Pharmaceutical compositions |
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-
2005
- 2005-12-23 AU AU2005322067A patent/AU2005322067B8/en not_active Expired
- 2005-12-23 JP JP2007548552A patent/JP5022231B2/ja not_active Expired - Lifetime
- 2005-12-23 PL PL05855442T patent/PL1835938T3/pl unknown
- 2005-12-23 DK DK05855442.9T patent/DK1835938T3/da active
- 2005-12-23 CN CN2005800445983A patent/CN101163506B/zh not_active Expired - Lifetime
- 2005-12-23 CA CA002591852A patent/CA2591852A1/en not_active Abandoned
- 2005-12-23 ES ES05855442T patent/ES2434035T3/es not_active Expired - Lifetime
- 2005-12-23 US US11/317,582 patent/US7884075B2/en active Active
- 2005-12-23 EP EP05855442.9A patent/EP1835938B1/en not_active Expired - Lifetime
- 2005-12-23 KR KR1020077017261A patent/KR20070092754A/ko not_active Withdrawn
- 2005-12-23 PT PT58554429T patent/PT1835938E/pt unknown
- 2005-12-23 MX MX2007007877A patent/MX2007007877A/es active IP Right Grant
- 2005-12-23 BR BRPI0519562-4A patent/BRPI0519562A2/pt not_active IP Right Cessation
- 2005-12-23 WO PCT/US2005/046879 patent/WO2006071801A2/en not_active Ceased
-
2007
- 2007-06-04 IL IL183634A patent/IL183634A/en active IP Right Grant
-
2011
- 2011-01-14 US US13/007,208 patent/US8076463B2/en not_active Expired - Lifetime
- 2011-11-28 US US13/305,334 patent/US8357779B2/en not_active Expired - Lifetime
-
2012
- 2012-03-30 JP JP2012081700A patent/JP5715983B2/ja not_active Expired - Lifetime
- 2012-12-21 US US13/724,831 patent/US8835388B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US7884075B2 (en) | 2011-02-08 |
| JP2012126750A (ja) | 2012-07-05 |
| US20110111455A1 (en) | 2011-05-12 |
| US20060160948A1 (en) | 2006-07-20 |
| ES2434035T3 (es) | 2013-12-13 |
| AU2005322067B2 (en) | 2012-07-05 |
| PT1835938E (pt) | 2013-11-06 |
| CN101163506B (zh) | 2012-09-26 |
| EP1835938B1 (en) | 2013-08-07 |
| MX2007007877A (es) | 2007-08-21 |
| JP2008525491A (ja) | 2008-07-17 |
| US20130190242A1 (en) | 2013-07-25 |
| IL183634A0 (en) | 2007-09-20 |
| AU2005322067B8 (en) | 2012-07-26 |
| IL183634A (en) | 2012-02-29 |
| KR20070092754A (ko) | 2007-09-13 |
| CN101163506A (zh) | 2008-04-16 |
| US8076463B2 (en) | 2011-12-13 |
| US8357779B2 (en) | 2013-01-22 |
| JP5715983B2 (ja) | 2015-05-13 |
| WO2006071801A2 (en) | 2006-07-06 |
| BRPI0519562A2 (pt) | 2009-01-27 |
| US20120135462A1 (en) | 2012-05-31 |
| HK1105276A1 (en) | 2008-02-06 |
| AU2005322067A1 (en) | 2006-07-06 |
| EP1835938A2 (en) | 2007-09-26 |
| US8835388B2 (en) | 2014-09-16 |
| JP5022231B2 (ja) | 2012-09-12 |
| WO2006071801A3 (en) | 2007-08-16 |
| CA2591852A1 (en) | 2006-07-06 |
| DK1835938T3 (da) | 2013-11-04 |
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