JP2010505902A5 - - Google Patents
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- Publication number
- JP2010505902A5 JP2010505902A5 JP2009531813A JP2009531813A JP2010505902A5 JP 2010505902 A5 JP2010505902 A5 JP 2010505902A5 JP 2009531813 A JP2009531813 A JP 2009531813A JP 2009531813 A JP2009531813 A JP 2009531813A JP 2010505902 A5 JP2010505902 A5 JP 2010505902A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- acceptable salt
- pharmaceutically acceptable
- hcv
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 150000001875 compounds Chemical class 0.000 claims 24
- 150000003839 salts Chemical class 0.000 claims 21
- 241000711549 Hepacivirus C Species 0.000 claims 12
- 239000003814 drug Substances 0.000 claims 12
- 229910052739 hydrogen Inorganic materials 0.000 claims 11
- 239000001257 hydrogen Substances 0.000 claims 11
- -1 monophosphate ester Chemical class 0.000 claims 9
- 102000014150 Interferons Human genes 0.000 claims 6
- 108010050904 Interferons Proteins 0.000 claims 6
- 125000000217 alkyl group Chemical group 0.000 claims 6
- 150000002431 hydrogen Chemical class 0.000 claims 6
- 210000000987 immune system Anatomy 0.000 claims 6
- 229940079322 interferon Drugs 0.000 claims 6
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 5
- 229940124683 HCV polymerase inhibitor Drugs 0.000 claims 4
- 239000003443 antiviral agent Substances 0.000 claims 4
- 239000002777 nucleoside Substances 0.000 claims 4
- 150000003833 nucleoside derivatives Chemical class 0.000 claims 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 4
- 125000003545 alkoxy group Chemical group 0.000 claims 3
- 239000003085 diluting agent Substances 0.000 claims 3
- 239000003937 drug carrier Substances 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 239000000546 pharmaceutical excipient Substances 0.000 claims 3
- 102000007644 Colony-Stimulating Factors Human genes 0.000 claims 2
- 108010071942 Colony-Stimulating Factors Proteins 0.000 claims 2
- 229940122604 HCV protease inhibitor Drugs 0.000 claims 2
- 229940121759 Helicase inhibitor Drugs 0.000 claims 2
- 102000015696 Interleukins Human genes 0.000 claims 2
- 108010063738 Interleukins Proteins 0.000 claims 2
- 229940122488 Primase inhibitor Drugs 0.000 claims 2
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 2
- 230000000840 anti-viral effect Effects 0.000 claims 2
- 230000037396 body weight Effects 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 239000007891 compressed tablet Substances 0.000 claims 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 229940125777 fusion inhibitor Drugs 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- 230000001404 mediated effect Effects 0.000 claims 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 2
- 230000010076 replication Effects 0.000 claims 2
- 239000001226 triphosphate Substances 0.000 claims 2
- 235000011178 triphosphate Nutrition 0.000 claims 2
- 102000003390 tumor necrosis factor Human genes 0.000 claims 2
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 claims 1
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 1
- KPPVNWGJXFMGAM-UUILKARUSA-N (e)-2-methyl-1-(6-methyl-3,4-dihydro-2h-quinolin-1-yl)but-2-en-1-one Chemical compound CC1=CC=C2N(C(=O)C(/C)=C/C)CCCC2=C1 KPPVNWGJXFMGAM-UUILKARUSA-N 0.000 claims 1
- 101100516563 Caenorhabditis elegans nhr-6 gene Proteins 0.000 claims 1
- 150000008575 L-amino acids Chemical class 0.000 claims 1
- 239000001177 diphosphate Substances 0.000 claims 1
- 235000011180 diphosphates Nutrition 0.000 claims 1
- 125000001188 haloalkyl group Chemical group 0.000 claims 1
- 125000004404 heteroalkyl group Chemical group 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- UUEVFMOUBSLVJW-UHFFFAOYSA-N oxo-[[1-[2-[2-[2-[4-(oxoazaniumylmethylidene)pyridin-1-yl]ethoxy]ethoxy]ethyl]pyridin-4-ylidene]methyl]azanium;dibromide Chemical compound [Br-].[Br-].C1=CC(=C[NH+]=O)C=CN1CCOCCOCCN1C=CC(=C[NH+]=O)C=C1 UUEVFMOUBSLVJW-UHFFFAOYSA-N 0.000 claims 1
- 125000003884 phenylalkyl group Chemical group 0.000 claims 1
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 0 CC(C)C(O[C@@]([C@]1C)[C@@](*)(CO)O[C@]1N(C=CC(N)=N1)C1=O)=O Chemical compound CC(C)C(O[C@@]([C@]1C)[C@@](*)(CO)O[C@]1N(C=CC(N)=N1)C1=O)=O 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US85092606P | 2006-10-10 | 2006-10-10 | |
| PCT/EP2007/060557 WO2008043704A1 (en) | 2006-10-10 | 2007-10-04 | Hcv nucleoside inhibitor |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011167159A Division JP2011246485A (ja) | 2006-10-10 | 2011-07-29 | 合成中間体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010505902A JP2010505902A (ja) | 2010-02-25 |
| JP2010505902A5 true JP2010505902A5 (show.php) | 2011-09-15 |
Family
ID=38925483
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009531813A Ceased JP2010505902A (ja) | 2006-10-10 | 2007-10-04 | Ｈｃｖヌクレオシド阻害剤 |
| JP2011167159A Ceased JP2011246485A (ja) | 2006-10-10 | 2011-07-29 | 合成中間体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011167159A Ceased JP2011246485A (ja) | 2006-10-10 | 2011-07-29 | 合成中間体 |
Country Status (31)
| Country | Link |
|---|---|
| US (4) | US7666856B2 (show.php) |
| EP (2) | EP2084175B1 (show.php) |
| JP (2) | JP2010505902A (show.php) |
| KR (1) | KR20090078347A (show.php) |
| CN (2) | CN101573370B (show.php) |
| AP (1) | AP2009004812A0 (show.php) |
| AT (1) | ATE493428T1 (show.php) |
| AU (1) | AU2007306405A1 (show.php) |
| BR (1) | BRPI0719258A2 (show.php) |
| CA (1) | CA2665049C (show.php) |
| CO (1) | CO6180441A2 (show.php) |
| CR (1) | CR10789A (show.php) |
| CY (1) | CY1111342T1 (show.php) |
| DE (1) | DE602007011658D1 (show.php) |
| DK (1) | DK2084175T3 (show.php) |
| EA (1) | EA018935B1 (show.php) |
| ES (2) | ES2392948T3 (show.php) |
| GT (1) | GT200900069A (show.php) |
| HN (1) | HN2009000614A (show.php) |
| HR (1) | HRP20110193T1 (show.php) |
| IL (1) | IL197907A0 (show.php) |
| MX (1) | MX2009003452A (show.php) |
| MY (1) | MY145314A (show.php) |
| NO (1) | NO20091834L (show.php) |
| NZ (1) | NZ575889A (show.php) |
| PL (2) | PL2361922T3 (show.php) |
| PT (1) | PT2084175E (show.php) |
| RS (1) | RS51643B (show.php) |
| SI (1) | SI2084175T1 (show.php) |
| WO (1) | WO2008043704A1 (show.php) |
| ZA (1) | ZA200902496B (show.php) |
Families Citing this family (37)
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| NZ575889A (en) * | 2006-10-10 | 2011-09-30 | Medivir Ab | Hcv nucleoside inhibitor |
| CN100532388C (zh) * | 2007-07-16 | 2009-08-26 | 郑州大学 | 2’-氟-4’-取代-核苷类似物、其制备方法及应用 |
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| EP2166016A1 (en) | 2008-09-18 | 2010-03-24 | Centocor Ortho Biotech Products L.P. | Phosphoramidate Derivatives of Nucleosides |
| AR073603A1 (es) * | 2008-09-18 | 2010-11-17 | Ortho Mcneil Janssen Pharm | Combinaciones sinergicas de un inhibidor macrociclico del vhc y un nucleosido |
| PA8852101A1 (es) | 2008-12-08 | 2010-07-27 | Medivir Ab | Nucleótidos uracil ciclopropílicos |
| DE102009028015A1 (de) * | 2009-07-24 | 2011-01-27 | Virologik Gmbh | Mittel zur Behandlung von Hepatitis C-Infektionen |
| US8552021B2 (en) | 2009-09-29 | 2013-10-08 | Janssen Products, L.P. | Phosphoramidate derivatives of nucleosides |
| JP5989635B2 (ja) | 2010-04-13 | 2016-09-07 | ジヤンセン・フアーマシユーチカルズ・インコーポレーテツド | Ｈｃｖの大環状阻害剤、非ヌクレオシドおよびヌクレオシドの組合せ |
| EA025341B1 (ru) | 2010-09-22 | 2016-12-30 | Алиос Биофарма, Инк. | Замещенные аналоги нуклеотидов |
| CA2812962C (en) | 2010-09-22 | 2020-03-31 | Alios Biopharma, Inc. | Azido nucleosides and nucleotide analogs |
| US9243025B2 (en) | 2011-03-31 | 2016-01-26 | Idenix Pharmaceuticals, Llc | Compounds and pharmaceutical compositions for the treatment of viral infections |
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| EP3027636B1 (en) | 2013-08-01 | 2022-01-05 | Idenix Pharmaceuticals LLC | D-amino acid phosphoramidate pronucleotides of halogeno pyrimidine compounds for liver disease |
| UA117375C2 (uk) * | 2013-09-04 | 2018-07-25 | Медівір Аб | Інгібітори полімерази hcv |
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| ES2361997T3 (es) | 2003-09-22 | 2011-06-27 | Boehringer Ingelheim International Gmbh | Péptidos macrocíclicos activos contra el virus de la hepatitis c. |
| DK1713823T3 (da) | 2004-01-30 | 2010-03-08 | Medivir Ab | HCV NS-3 serinproteaseinhibitorer |
| ATE437875T1 (de) | 2004-08-23 | 2009-08-15 | Hoffmann La Roche | Heterozyklische antivirale verbindungen |
| ES2327252T3 (es) * | 2004-08-23 | 2009-10-27 | F. Hoffmann-La Roche Ag | 4'-azido nucleosidos antivirales. |
| NZ575889A (en) * | 2006-10-10 | 2011-09-30 | Medivir Ab | Hcv nucleoside inhibitor |
-
2007
- 2007-10-04 NZ NZ575889A patent/NZ575889A/en not_active IP Right Cessation
- 2007-10-04 CN CN2007800379054A patent/CN101573370B/zh not_active Expired - Fee Related
- 2007-10-04 WO PCT/EP2007/060557 patent/WO2008043704A1/en not_active Ceased
- 2007-10-04 PL PL10196341T patent/PL2361922T3/pl unknown
- 2007-10-04 DE DE602007011658T patent/DE602007011658D1/de active Active
- 2007-10-04 EP EP07820934A patent/EP2084175B1/en active Active
- 2007-10-04 CA CA2665049A patent/CA2665049C/en not_active Expired - Fee Related
- 2007-10-04 DK DK07820934.3T patent/DK2084175T3/da active
- 2007-10-04 EA EA200970358A patent/EA018935B1/ru not_active IP Right Cessation
- 2007-10-04 CN CN201010274006XA patent/CN101979397B/zh not_active Expired - Fee Related
- 2007-10-04 KR KR1020097009591A patent/KR20090078347A/ko not_active Ceased
- 2007-10-04 JP JP2009531813A patent/JP2010505902A/ja not_active Ceased
- 2007-10-04 PT PT07820934T patent/PT2084175E/pt unknown
- 2007-10-04 BR BRPI0719258-4A2A patent/BRPI0719258A2/pt active Search and Examination
- 2007-10-04 SI SI200730544T patent/SI2084175T1/sl unknown
- 2007-10-04 ES ES10196341T patent/ES2392948T3/es active Active
- 2007-10-04 AU AU2007306405A patent/AU2007306405A1/en not_active Abandoned
- 2007-10-04 RS RS20110127A patent/RS51643B/sr unknown
- 2007-10-04 HR HR20110193T patent/HRP20110193T1/hr unknown
- 2007-10-04 ES ES07820934T patent/ES2358853T3/es active Active
- 2007-10-04 AP AP2009004812A patent/AP2009004812A0/xx unknown
- 2007-10-04 PL PL07820934T patent/PL2084175T3/pl unknown
- 2007-10-04 AT AT07820934T patent/ATE493428T1/de active
- 2007-10-04 MX MX2009003452A patent/MX2009003452A/es active IP Right Grant
- 2007-10-04 MY MYPI20091428A patent/MY145314A/en unknown
- 2007-10-04 EP EP10196341A patent/EP2361922B1/en active Active
- 2007-10-10 US US11/973,681 patent/US7666856B2/en not_active Expired - Fee Related
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2009
- 2009-03-31 CO CO09033094A patent/CO6180441A2/es not_active Application Discontinuation
- 2009-03-31 GT GT200900069A patent/GT200900069A/es unknown
- 2009-04-05 IL IL197907A patent/IL197907A0/en unknown
- 2009-04-09 ZA ZA200902496A patent/ZA200902496B/xx unknown
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- 2009-05-11 CR CR10789A patent/CR10789A/es not_active Application Discontinuation
- 2009-05-11 NO NO20091834A patent/NO20091834L/no not_active Application Discontinuation
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2010
- 2010-01-20 US US12/690,842 patent/US7825239B2/en not_active Expired - Fee Related
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2011
- 2011-03-17 CY CY20111100298T patent/CY1111342T1/el unknown
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- 2011-07-29 JP JP2011167159A patent/JP2011246485A/ja not_active Ceased
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