CO6180441A2 - Inhibidores nucleosidos del hcv - Google Patents

Inhibidores nucleosidos del hcv

Info

Publication number
CO6180441A2
CO6180441A2 CO09033094A CO09033094A CO6180441A2 CO 6180441 A2 CO6180441 A2 CO 6180441A2 CO 09033094 A CO09033094 A CO 09033094A CO 09033094 A CO09033094 A CO 09033094A CO 6180441 A2 CO6180441 A2 CO 6180441A2
Authority
CO
Colombia
Prior art keywords
hydrogen
compound according
cor4
phenyl
group
Prior art date
Application number
CO09033094A
Other languages
English (en)
Inventor
Nils-Gunnar Johansson
Genadiy Kalayanov
Joseph Armstrong Martin
David Bernard Smith
Anna Winqvist
Original Assignee
Medivir Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medivir Ab filed Critical Medivir Ab
Publication of CO6180441A2 publication Critical patent/CO6180441A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/073—Pyrimidine radicals with 2-deoxyribosyl as the saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/191—Tumor necrosis factors [TNF], e.g. lymphotoxin [LT], i.e. TNF-beta
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/193—Colony stimulating factors [CSF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

1.- Un compuesto de fórmula Idonde: R1, R2 y R3 se seleccionan en forma independiente entre el grupo que consiste en hidrógeno, COR4, C(=O)OR4 y C(=O)CHR5NHR6; o R1 y R3 son H y R2 es el éster monofosfato, difosfato o trifosfato; R4 se selecciona en forma independiente entre el grupo que consiste en (a) C1-18 alquilo lineal o ramificado, (b) C1-18 haloalquilo, (c) C3-8 cicloalquilo, (d) C1-10 heteroalquilo y (e) fenilo donde dicho fenilo está opcionalmente sustituido con entre uno y tres grupos seleccionados en forma independiente entre C1-3 alquilo, C1-3 alcoxi, halógeno, ciano o nitro; R5 es hidrógeno, C1-10 alquilo, fenilo o C1-3 fenilalquilo donde dicho fenilo está opcionalmente sustituido con entre uno y tres grupos seleccionados en forma independiente entre el grupo que consiste en halógeno, hidroxi, C1-3 alcoxi, C1-3 alquilo, ciano y nitro; R6 es hidrógeno o C1-6 alcoxi; o, sales de adición ácida del mismo. 2.- Un compuesto de acuerdo con la reivindicación 1 en donde R1, R2 y R3 son en cada caso hidrógeno. 3.- Un compuesto de acuerdo con la reivindicación 1 en donde R1, R2 y R3 son cada uno en forma independiente hidrógeno, OCR4 o C(=O)OR4. 4.- Un compuesto de acuerdo con la reivindicación 3 en donde R4 es C1-10 alquilo lineal o ramificado. 5.- Un compuesto de acuerdo con la reivindicación 1 en donde R1 es hidrógeno y R2 y R3 son COR4. 6.- Un compuesto de acuerdo con la reivindicación 1 en donde R1 es hidrógeno, R2 y R3 son COR4 y R4 es alquilo lineal o ramificado; o una sal farmacéuticamente aceptable del mismo. 7.- Un compuesto de acuerdo con la reivindicación 1 en donde R1 y R3 son hidrógeno R2 se selecciona entre el grupo que consiste en COR4, C(=O)OR4 y COCH(R5)NHR6. 8.- Un compuesto de acuerdo con la reivindicación 7 en donde R2 es COCH(R5)NHR6, R5 es iso-propilo, iso-butilo o sec-butilo y R6 es hidrógeno. 9.- Un compuesto de acuerdo con la reivindicación 8 en donde R5 tiene la estereoquímica de un L-aminoácido. 10.- Un compuesto de acuerdo con la reivindicación 7, en donde R2 es OCR4.
CO09033094A 2006-10-10 2009-03-31 Inhibidores nucleosidos del hcv CO6180441A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US85092606P 2006-10-10 2006-10-10

Publications (1)

Publication Number Publication Date
CO6180441A2 true CO6180441A2 (es) 2010-07-19

Family

ID=38925483

Family Applications (1)

Application Number Title Priority Date Filing Date
CO09033094A CO6180441A2 (es) 2006-10-10 2009-03-31 Inhibidores nucleosidos del hcv

Country Status (32)

Country Link
US (4) US7666856B2 (es)
EP (2) EP2361922B1 (es)
JP (2) JP2010505902A (es)
KR (1) KR20090078347A (es)
CN (2) CN101573370B (es)
AP (1) AP2009004812A0 (es)
AT (1) ATE493428T1 (es)
AU (1) AU2007306405A1 (es)
BR (1) BRPI0719258A2 (es)
CA (1) CA2665049C (es)
CO (1) CO6180441A2 (es)
CR (1) CR10789A (es)
CY (1) CY1111342T1 (es)
DE (1) DE602007011658D1 (es)
DK (1) DK2084175T3 (es)
EA (1) EA018935B1 (es)
ES (2) ES2358853T3 (es)
GT (1) GT200900069A (es)
HK (2) HK1137459A1 (es)
HN (1) HN2009000614A (es)
HR (1) HRP20110193T1 (es)
IL (1) IL197907A0 (es)
MX (1) MX2009003452A (es)
MY (1) MY145314A (es)
NO (1) NO20091834L (es)
NZ (1) NZ575889A (es)
PL (2) PL2361922T3 (es)
PT (1) PT2084175E (es)
RS (1) RS51643B (es)
SI (1) SI2084175T1 (es)
WO (1) WO2008043704A1 (es)
ZA (1) ZA200902496B (es)

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ES2358853T3 (es) 2011-05-16
DK2084175T3 (da) 2011-04-18
GT200900069A (es) 2009-11-06
JP2010505902A (ja) 2010-02-25
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EP2084175B1 (en) 2010-12-29
EA200970358A1 (ru) 2009-12-30
DE602007011658D1 (de) 2011-02-10
EP2084175A1 (en) 2009-08-05
EA018935B1 (ru) 2013-11-29
BRPI0719258A2 (pt) 2014-04-29
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HK1154247A1 (en) 2012-04-13
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