AR056686A1 - Derivados de diacilindazol como inhibidores de lipasas y fosfolipasas - Google Patents

Derivados de diacilindazol como inhibidores de lipasas y fosfolipasas

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Publication number
AR056686A1
AR056686A1 ARP060104444A ARP060104444A AR056686A1 AR 056686 A1 AR056686 A1 AR 056686A1 AR P060104444 A ARP060104444 A AR P060104444A AR P060104444 A ARP060104444 A AR P060104444A AR 056686 A1 AR056686 A1 AR 056686A1
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AR
Argentina
Prior art keywords
alkyl
heterocycle
identically
differently
amino
Prior art date
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ARP060104444A
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English (en)
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Sanofi Aventis Deutschland
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Application filed by Sanofi Aventis Deutschland filed Critical Sanofi Aventis Deutschland
Publication of AR056686A1 publication Critical patent/AR056686A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
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  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • General Health & Medical Sciences (AREA)
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  • General Chemical & Material Sciences (AREA)
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  • Diabetes (AREA)
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  • Dermatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
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  • Neurology (AREA)
  • Pulmonology (AREA)
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  • Urology & Nephrology (AREA)
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  • Psychiatry (AREA)
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  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Un compuesto de formulas (1) o (2) en la que X de forma idéntica o diferente, es =C(-R)- o =N-, en el que no más de dos X son =N-; R de forma idéntica o diferente, es H, halogeno, alquilo C1-6, alquiloxi C1-3-alquileno C1-3, haloalquilo C1-3, hidroxi, alquil C1-6-mercapto, amino, alquil C1-6-amino, dialquil C2-12-amino, monoalquil C1-6-aminocarbonilo, dialquil C2-8-aminocarbonilo, COOR3, ciano, alquil C1-6-sulfonilo, alquil C1-6-sulfinilo, aminosulfonilo, nitro, pentafluorosulfanilo, fenilo, heterociclo, fenoxi, O-heterociclo, CO-NR6R7, O-CO-NR6R7, O-CO-alquilen C1-6-CO-O-alquilo C1-6, O-CO-alquilen C1-6-CO-OH, O-CO-alquilen C1-6-CO-NR6R7 o alquiloxi C1-6 no sustituido o mono- o poli-F-sustituido; de forma idéntica o diferente, es alquilo C5-16, cicloalquilo C3-12, Y-arilo, Y-heterociclo o biciclo, en los que el cicloalquilo, arilo, heterociclo o biciclo puede estar sustituido una o más veces con halogeno, alquilo C1-6, alquiloxi C1-3, hidroxi, alquil C1-6-mercapto, amino, alquil C1-6-amino, dialquil C2-12-amino, monoalquil C1-6-aminocarbonilo, dialquil C2-8-aminocarbonilo, alquiloxi C1-6-carbonilo, alquil C1-6-carbonilo, ciano, trifluorometilo, trifluorometoxi, alquil C1-6-sulfonilo, aminosulfonilo, nitro; Y es alquilo c1-3, que puede estar sustituido una o más veces con halogeno, alquilo C1-3, hidroxi o trifluorometilo; R2 es H, o R1 y R2 junto con el átomo de N al que están unidos son un sistema de anillos monocíclico, saturado o parcialmente insaturado de 4 a 7 miembros, o un sistema de anillos bicíclico saturado o parcialmente insaturado, de 8 a 14 miembros, cuyos miembros individuales de los sistemas de anillos pueden estar reemplazados por uno a tres átomos o grupos atomicos de la serie -CHR4-, -CR4R5-, -(C=R4)-, -NR4-, -C(=O)-, -O-, -S-, -SO-, -SO2-, con la condicion de que dos unidades de la serie -O-, -S-, -SO-, -SO2- pueden no estar adyacentes; R3 es H, alquilo C1-6, bencilo; R4, R5 de forma idéntica o diferente, sn alquilo C16, halogeno, trifluorometilo, fenilo, heterociclo, COOR3, cicloalquilo C3-12; R6, R7 de forma idéntica o diferente, son H, alquilo C1-6, fenilo, bencilo, cicloalquilo C3-12; las formas tautomeras de los compuestos y sus sales fisiologicamente toleradas, con la condicion de que no más de un R es fenilo o heterociclo.
ARP060104444A 2005-10-12 2006-10-10 Derivados de diacilindazol como inhibidores de lipasas y fosfolipasas AR056686A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102005048897A DE102005048897A1 (de) 2005-10-12 2005-10-12 Diacylindazol-derivate als Inhibitoren von Lipasen und Phospholipasen

Publications (1)

Publication Number Publication Date
AR056686A1 true AR056686A1 (es) 2007-10-17

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ID=37813518

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ARP060104444A AR056686A1 (es) 2005-10-12 2006-10-10 Derivados de diacilindazol como inhibidores de lipasas y fosfolipasas

Country Status (18)

Country Link
US (2) US7772268B2 (es)
EP (1) EP1937648B1 (es)
JP (1) JP2009511517A (es)
KR (1) KR20080048062A (es)
CN (1) CN101282939A (es)
AR (1) AR056686A1 (es)
AU (1) AU2006301591A1 (es)
BR (1) BRPI0617222A2 (es)
CA (1) CA2625546A1 (es)
DE (1) DE102005048897A1 (es)
IL (1) IL190672A0 (es)
MA (1) MA29856B1 (es)
NO (1) NO20081878L (es)
RU (1) RU2008114360A (es)
TW (1) TW200728285A (es)
UY (1) UY29853A1 (es)
WO (1) WO2007042178A1 (es)
ZA (1) ZA200802105B (es)

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