AR065724A1 - Macrolidos - Google Patents

Macrolidos

Info

Publication number
AR065724A1
AR065724A1 ARP080101036A ARP080101036A AR065724A1 AR 065724 A1 AR065724 A1 AR 065724A1 AR P080101036 A ARP080101036 A AR P080101036A AR P080101036 A ARP080101036 A AR P080101036A AR 065724 A1 AR065724 A1 AR 065724A1
Authority
AR
Argentina
Prior art keywords
hydroxy
naphthyridin
group
hydrogen
formula
Prior art date
Application number
ARP080101036A
Other languages
English (en)
Inventor
Richard Buzon Sr
Mark E Flanagan
Zhengong Bryan Li
Thomas V Magee
Usa Reilly
Daniel William Widlicka
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of AR065724A1 publication Critical patent/AR065724A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La presente también se refiere a composiciones farmacéuticas y procedimientos de tratamiento de infecciones bacterianas usando los compuestos de formula (1). Reivindicacion 1: i. Un compuesto caracterizado porque es de formula (1), en la que R1 seselecciona entre el grupo constituido por 3-hidroxi-[1,5]-naftiridin-4-ilo, 3-hidroxi-[1,6]-naftiridin-4-ilo, y 3-hidroxi-[1,7]-naftiridin-4-ilo, en la que dichos 3-hidroxi-[1,5]-naftiridin-4-ilo, 3-hidroxi-[1,6]-naftiridin-4-ilo, y 3-hidroxi-[1,7]-naftiridin-4-ilo, están opcionalmente sustituidos con un grupo seleccionado entre el grupo constituido por alquilo C1-3, ciclopropilo, y ciclobutilo; R2 se selecciona entre el grupo constituido por hidrogeno, metilo, y etilo; y X es hidrogeno ofluor; o su sal farmacéuticamente aceptable.
ARP080101036A 2007-03-13 2008-03-13 Macrolidos AR065724A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US89447507P 2007-03-13 2007-03-13
US2337008P 2008-01-24 2008-01-24

Publications (1)

Publication Number Publication Date
AR065724A1 true AR065724A1 (es) 2009-06-24

Family

ID=39760163

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP080101036A AR065724A1 (es) 2007-03-13 2008-03-13 Macrolidos

Country Status (28)

Country Link
US (1) US20080293646A1 (es)
EP (1) EP2125851B1 (es)
JP (1) JP4468487B1 (es)
KR (1) KR20090110381A (es)
CN (1) CN101631795A (es)
AP (1) AP2009004985A0 (es)
AR (1) AR065724A1 (es)
AT (1) ATE471943T1 (es)
AU (1) AU2008224633A1 (es)
BR (1) BRPI0809002A2 (es)
CA (1) CA2680527A1 (es)
CL (1) CL2008000695A1 (es)
CR (1) CR10998A (es)
CU (1) CU20090155A7 (es)
DE (1) DE602008001611D1 (es)
DO (1) DOP2009000214A (es)
EA (1) EA200901059A1 (es)
EC (1) ECSP099627A (es)
IL (1) IL200613A0 (es)
MA (1) MA31252B1 (es)
MX (1) MX2009009074A (es)
PA (1) PA8772401A1 (es)
PE (1) PE20090106A1 (es)
SV (1) SV2009003368A (es)
TN (1) TN2009000374A1 (es)
TW (1) TW200848061A (es)
UY (1) UY30957A1 (es)
WO (1) WO2008110918A2 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LT2822953T (lt) * 2012-03-06 2017-04-10 Pfizer Inc. Makrocikliniai dariniai, skirti proliferacinių ligų gydymui
US9982005B2 (en) 2013-04-04 2018-05-29 President And Fellows Of Harvard College Macrolides and methods of their preparation and use
WO2016057798A1 (en) * 2014-10-08 2016-04-14 President And Fellows Of Harvard College 14-membered ketolides and methods of their preparation and use
CN107530365A (zh) 2015-03-25 2018-01-02 哈佛大学的校长及成员们 具有修饰的脱氧糖胺糖的大环内酯及其用途
CN105924451B (zh) * 2016-04-27 2017-12-15 国家海洋局第三海洋研究所 具有抗茶叶致病真菌活性的大环内酯化合物及制备与用途

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1836211B1 (en) * 2004-12-21 2010-03-03 Pfizer Products Inc. Macrolides

Also Published As

Publication number Publication date
CR10998A (es) 2009-09-11
US20080293646A1 (en) 2008-11-27
ATE471943T1 (de) 2010-07-15
CA2680527A1 (en) 2008-09-18
EA200901059A1 (ru) 2010-02-26
EP2125851A2 (en) 2009-12-02
AU2008224633A1 (en) 2008-09-18
UY30957A1 (es) 2008-10-31
WO2008110918A3 (en) 2009-01-29
MA31252B1 (fr) 2010-03-01
EP2125851B1 (en) 2010-06-23
IL200613A0 (en) 2010-05-17
ECSP099627A (es) 2009-10-30
SV2009003368A (es) 2009-11-09
JP2010521448A (ja) 2010-06-24
CN101631795A (zh) 2010-01-20
CL2008000695A1 (es) 2008-09-22
CU20090155A7 (es) 2011-04-26
BRPI0809002A2 (pt) 2014-11-11
WO2008110918A2 (en) 2008-09-18
DE602008001611D1 (en) 2010-08-05
TW200848061A (en) 2008-12-16
TN2009000374A1 (fr) 2010-12-31
JP4468487B1 (ja) 2010-05-26
PE20090106A1 (es) 2009-02-08
DOP2009000214A (es) 2009-10-31
KR20090110381A (ko) 2009-10-21
PA8772401A1 (es) 2008-11-19
MX2009009074A (es) 2009-09-28
AP2009004985A0 (en) 2009-10-31

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