ECSP088965A - Derivados de 2-tioxantina que actúan como inhibidores de la mpo - Google Patents

Derivados de 2-tioxantina que actúan como inhibidores de la mpo

Info

Publication number
ECSP088965A
ECSP088965A EC2008008965A ECSP088965A ECSP088965A EC SP088965 A ECSP088965 A EC SP088965A EC 2008008965 A EC2008008965 A EC 2008008965A EC SP088965 A ECSP088965 A EC SP088965A EC SP088965 A ECSP088965 A EC SP088965A
Authority
EC
Ecuador
Prior art keywords
thioxantine
mpo
inhibitors
derivatives
act
Prior art date
Application number
EC2008008965A
Other languages
English (en)
Inventor
Anna-Karin Tiden
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of ECSP088965A publication Critical patent/ECSP088965A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/22—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one sulfur atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Resumen: La presente invención se relaciona con un compuesto de acuerdo a la Fórmula (I) donde R1 es seleccionado de C1-C6 alquil, y dicho C1-C6 alquil es sustituido con C1-C6 alcoxi; y al menos uno de dicho C1-C6 alquil o dicho C1-C6 alcoxi es ramificado; o un sal farmacéuticamente aceptable del mismo, solvato o solvato de una sal del mismo, con composiciones que contienen el compuesto y el uso del mismo en terapia.
EC2008008965A 2006-06-05 2008-12-12 Derivados de 2-tioxantina que actúan como inhibidores de la mpo ECSP088965A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US81091906P 2006-06-05 2006-06-05

Publications (1)

Publication Number Publication Date
ECSP088965A true ECSP088965A (es) 2009-01-30

Family

ID=38801720

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2008008965A ECSP088965A (es) 2006-06-05 2008-12-12 Derivados de 2-tioxantina que actúan como inhibidores de la mpo

Country Status (20)

Country Link
US (2) US7943625B2 (es)
EP (1) EP2029598A4 (es)
JP (1) JP2009539828A (es)
KR (1) KR20090014189A (es)
CN (1) CN101460498A (es)
AR (1) AR061134A1 (es)
AU (1) AU2007256005B2 (es)
BR (1) BRPI0712310A2 (es)
CA (1) CA2653774A1 (es)
CL (1) CL2007001590A1 (es)
EC (1) ECSP088965A (es)
IL (1) IL195287A0 (es)
MX (1) MX2008014991A (es)
NO (1) NO20085269L (es)
RU (1) RU2435772C2 (es)
TW (1) TW200804383A (es)
UA (1) UA94606C2 (es)
UY (1) UY30387A1 (es)
WO (1) WO2007142576A1 (es)
ZA (1) ZA200809800B (es)

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TW200804383A (en) * 2006-06-05 2008-01-16 Astrazeneca Ab New compounds
US20090053176A1 (en) * 2007-08-23 2009-02-26 Astrazeneca Ab New Combination 937
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US8765126B2 (en) * 2011-05-05 2014-07-01 Robert Sackstein Methods of treating complications and disorders associated with G-CSF administration
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US9221821B2 (en) * 2012-06-05 2015-12-29 Forest Laboratories Holdings, Limited Methods for the synthesis of 1,3-substituted aminouracils and other xanthine-related compounds
US9932329B2 (en) 2014-03-03 2018-04-03 Principia Biopharma, Inc. Benzimidazole derivatives as RLK and ITK inhibitors
WO2015196245A1 (en) * 2014-06-25 2015-12-30 Adelaide Research & Innovation Pty Ltd Modulation of osteogenesis and or angiogenesis by modulating peroxidase functionality
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WO2016191172A1 (en) 2015-05-22 2016-12-01 Principia Biopharma Inc. Quinolone derivatives as fibroblast growth factor receptor inhibitors
KR20240070721A (ko) 2015-06-03 2024-05-21 프린시피아 바이오파마, 인코퍼레이티드 티로신 키나제 억제제
UY40399A (es) 2022-08-18 2024-02-15 Astrazeneca Ab Inhibidores de mieloperoxidasa
EP4624473A1 (en) * 2022-12-09 2025-10-01 Shenzhen Salubris Pharmaceuticals Co., Ltd. Pyrrolo[3,2-d]pyrimidin-4-one derivative, and preparation method therefor and medical use thereof
WO2025172474A1 (en) 2024-02-15 2025-08-21 Astrazeneca Ab Inhibitors of myeloperoxidase
WO2025190901A1 (en) 2024-03-13 2025-09-18 Institut National de la Santé et de la Recherche Médicale Use of myeloperoxidase (mpo) inhibitors for promoting cd8+ t cell responses

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Also Published As

Publication number Publication date
CL2007001590A1 (es) 2008-01-25
AU2007256005B2 (en) 2011-03-17
MX2008014991A (es) 2008-12-05
CA2653774A1 (en) 2007-12-13
RU2008145971A (ru) 2010-07-20
ZA200809800B (en) 2010-04-28
WO2007142576A1 (en) 2007-12-13
US20090131459A1 (en) 2009-05-21
KR20090014189A (ko) 2009-02-06
BRPI0712310A2 (pt) 2012-01-17
CN101460498A (zh) 2009-06-17
RU2435772C2 (ru) 2011-12-10
UY30387A1 (es) 2008-01-31
AR061134A1 (es) 2008-08-06
AU2007256005A1 (en) 2007-12-13
US20080221133A1 (en) 2008-09-11
US7943625B2 (en) 2011-05-17
EP2029598A1 (en) 2009-03-04
UA94606C2 (ru) 2011-05-25
IL195287A0 (en) 2009-08-03
JP2009539828A (ja) 2009-11-19
TW200804383A (en) 2008-01-16
NO20085269L (no) 2009-03-05
EP2029598A4 (en) 2010-02-17

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