AR054266A1 - Indoles sustituidos con piperidina - Google Patents

Indoles sustituidos con piperidina

Info

Publication number
AR054266A1
AR054266A1 AR20060101713A ARP060101713A AR054266A1 AR 054266 A1 AR054266 A1 AR 054266A1 AR 20060101713 A AR20060101713 A AR 20060101713A AR P060101713 A ARP060101713 A AR P060101713A AR 054266 A1 AR054266 A1 AR 054266A1
Authority
AR
Argentina
Prior art keywords
alkyl
het
cycloalkyl
aryl
halogen
Prior art date
Application number
AR20060101713A
Other languages
English (en)
Inventor
Peter Seither
Silke Hobbie
Thierry Bouyssou
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of AR054266A1 publication Critical patent/AR054266A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Dermatology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biomedical Technology (AREA)
  • Vascular Medicine (AREA)
  • Neurosurgery (AREA)
  • Communicable Diseases (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Otolaryngology (AREA)
  • Toxicology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Objeto de la presente, es proporcionar agonistas o antagonistas de CCR-3 o sales farmacéuticamente aceptables de los mismos, más particularmente proporcionar composiciones farmacéuticas que comprenden un soporte farmacéuticamente aceptable y una cantidad terapéuticamente eficaz de al menos uno de los compuestos de la presente o una sal farmacéuticamente aceptable de los mismos. Proceso y uso. Reivindicacion 1: Un compuesto de formula (1) en la que R1 es arilo, het o una especie condensada del mismo, en donde het es un anillo heterocíclico y la especie condensada comprende condensaciones arilo-het, het-arilo o het-het, cada uno de dicho arilo o het puede estar sustituido con 1, 2 o 3 R2; R2 son, cada uno independientemente, alquilo C1- 6, cicloalquilo C3-6, haloalquilo C1-6, aralquilo C6-10, halogeno, CN, COOR3, COR3, CONR3R4, NR3R4, NR3SO2R4, OR3, NO2, SR3, SOR3, SO2R3 o SO2NR3R4; R3 es H, alquilo C1-6, cicloalquilo C3-8 o (-cicloalquil C3-8)-alquilo C1-6; R4 es H, alquilo C1-6, cicloalquilo C3-8 o (-cicloalquil C3-8)-alquilo C1-6; o R5 es alquilo C1-6, alcoxi C1-6, aciloxi C1-6, aralquilo C6-10, cicloalquilo C3-6, (cicloalquil C3-6)-alquilo C1-6, haloalquilo C1-6, tioalquilo C1-6, halogeno, NO2, CN, NR3R4; R6 son, cada uno independientemente, alquilo C1-6, alcoxi C1-6, aciloxi C1-6,aralquilo C6-10, cicloalquilo C3-6, haloalquilo C1-6, tioalquilo C1-6, halogeno, OR3, SR3, CN, NO2, COOR3, COR3, CONR3R4, NR3R4, NR3COR4, NR3SO2R4, SOR3, SO2R3, SO2NR3R4, arilo o het; R7 es H o un sustituyente seleccionado del grupo que consiste en arilo y het, ambos opcionalmente sustituidos con 1, 2, 3 o 4 sustituyentes seleccionados del grupo que consiste en H, COOR7.1, SO2R7.1, halogeno, OH, O-alquilo C1-6-, CN, PO(OH)2, CONHCN, SO2NHCOR7.1, SO2NHR7.1 y R7.2; R7.1 es H, alquilo C1-6 o arilo; R7.2 es un anillo heterocíclico de 5 o 6 miembros, aromático o no aromático, que contiene 1, 2, 3 o 4 átomos seleccionados del grupo que consiste en N, S y O, opcionalmente sustituido con 1, 2 o 3 oxo; R8 es H, OH, O-alquilo C1-6, haloalquilo C1-6, halogeno; R9 es H, OH, O-alquilo C1-6, haloalquilo C1-6, halogeno, A es un alquileno C2-8 lineal, ramificado o cíclico, opcionalmente sustituido con R9; B es arilo o het, D-E es -CH- CH2-, -C=CH-, -CR8-CH2-; Y es -CH2-, NHR4-, NR24, -O-, -S(O)n-; i, j son, cada uno independientemente, 0, 1 o 2, en donde 0 <= i + j <= 4; n es 0, 1 o 2; m es 0, 1, 2, 3 o 4; y sales farmacéuticamente aceptables de los mismos, con la condicion de que tanto R7 como R8 no puedan tener el significado de H al mismo tiempo.
AR20060101713A 2005-04-30 2006-04-28 Indoles sustituidos con piperidina AR054266A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP05009556 2005-04-30

Publications (1)

Publication Number Publication Date
AR054266A1 true AR054266A1 (es) 2007-06-13

Family

ID=36809076

Family Applications (1)

Application Number Title Priority Date Filing Date
AR20060101713A AR054266A1 (es) 2005-04-30 2006-04-28 Indoles sustituidos con piperidina

Country Status (8)

Country Link
US (1) US7759365B2 (es)
EP (1) EP1994019B1 (es)
JP (1) JP5080450B2 (es)
AR (1) AR054266A1 (es)
AT (1) ATE531706T1 (es)
CA (1) CA2606550C (es)
TW (1) TW200716597A (es)
WO (1) WO2006117314A2 (es)

Families Citing this family (10)

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Publication number Priority date Publication date Assignee Title
JP4825679B2 (ja) * 2003-11-17 2011-11-30 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規ピペリジン置換インドール又はこれらのヘテロ誘導体
CA2667547C (en) * 2006-10-27 2014-07-29 Boehringer Ingelheim International Gmbh Piperidyl-propane-thiol ccr3 modulators
US8148403B2 (en) * 2006-10-27 2012-04-03 Boehringer Ingelheim International Gmbh Substituted piperidyl-propane-thiols
US10213421B2 (en) 2012-04-04 2019-02-26 Alkahest, Inc. Pharmaceutical formulations comprising CCR3 antagonists
US9877957B2 (en) 2014-09-05 2018-01-30 Merck Sharp & Dohme Corp. Tetrahydroisoquinoline derivatives useful as inhibitors of diacylglyceride O-acyltransferase 2
EP3188731B1 (en) 2014-09-05 2019-04-03 Merck Sharp & Dohme Corp. Isoquinoline derivatives useful as inhibitors of diacylglyceride o-acyltransferase 2
WO2016036633A1 (en) 2014-09-05 2016-03-10 Merck Sharp & Dohme Corp. Tetrahydroisoquinoline derivatives useful as inhibitors of diacylglyceride o-acyltransferase 2
EP3541376B1 (en) 2016-11-18 2023-04-19 Merck Sharp & Dohme LLC Indole derivatives useful as inhibitors of diacylglyceride o-acyltransferase 2
JP2020502058A (ja) 2016-11-18 2020-01-23 メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． ジアシルグリセリドｏ−アシルトランスフェラーゼ２の阻害薬として有用なインダゾール誘導体
TWI833819B (zh) 2018-10-05 2024-03-01 美商安尼波那生物公司 用於治療與apj受體活性相關的病狀的化合物及組成物

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Also Published As

Publication number Publication date
TW200716597A (en) 2007-05-01
EP1994019A2 (en) 2008-11-26
ATE531706T1 (de) 2011-11-15
US7759365B2 (en) 2010-07-20
JP2008540333A (ja) 2008-11-20
CA2606550A1 (en) 2006-11-09
WO2006117314A2 (en) 2006-11-09
JP5080450B2 (ja) 2012-11-21
CA2606550C (en) 2014-05-27
WO2006117314A3 (en) 2007-01-18
EP1994019B1 (en) 2011-11-02
US20060247230A1 (en) 2006-11-02

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