JP2008525498A5

JP2008525498A5 -

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Publication number: JP2008525498A5
Authority: JP; Japan
Prior art keywords: pyrazol; urea; phenyl; alkyl; yloxy
Prior art date: 2005-12-23
Legal status : Granted

Application number

JP2007548595A

Other languages

English (en)

Japanese (ja)

Other versions

JP5197016B2 (ja

JP2008525498A (ja

Filing date

2005-12-23

Publication date

2009-02-19

2005-12-23 Application filed filed Critical

2005-12-23 Priority claimed from PCT/US2005/047270 external-priority patent/WO2006071940A2/en

2008-07-17 Publication of JP2008525498A publication Critical patent/JP2008525498A/ja

2009-02-19 Publication of JP2008525498A5 publication Critical patent/JP2008525498A5/ja

2013-05-15 Application granted granted Critical

2013-05-15 Publication of JP5197016B2 publication Critical patent/JP5197016B2/ja

2025-12-23 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

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-1 hydroxy C1-C6 alkyl Chemical group 0.000 claims 676
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 244
XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims 232
239000004202 carbamide Substances 0.000 claims 232
125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 139
150000001875 compounds Chemical class 0.000 claims 87
125000001072 heteroaryl group Chemical group 0.000 claims 68
125000004452 carbocyclyl group Chemical group 0.000 claims 60
125000000217 alkyl group Chemical group 0.000 claims 58
125000000623 heterocyclic group Chemical group 0.000 claims 57
229910052760 oxygen Inorganic materials 0.000 claims 39
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 38
125000004943 pyrimidin-6-yl group Chemical group N1=CN=CC=C1* 0.000 claims 38
229910052717 sulfur Inorganic materials 0.000 claims 36
125000002950 monocyclic group Chemical group 0.000 claims 34
125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 33
125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 33
125000001624 naphthyl group Chemical group 0.000 claims 32
229910052799 carbon Inorganic materials 0.000 claims 30
125000004076 pyridyl group Chemical group 0.000 claims 30
125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 29
229910052757 nitrogen Inorganic materials 0.000 claims 28
125000000714 pyrimidinyl group Chemical group 0.000 claims 28
125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 27
125000000250 methylamino group Chemical group [H]N(*)C([H])([H])[H] 0.000 claims 27
229910052739 hydrogen Inorganic materials 0.000 claims 23
125000005842 heteroatom Chemical group 0.000 claims 22
125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 20
125000003118 aryl group Chemical group 0.000 claims 20
229910052736 halogen Inorganic materials 0.000 claims 20
150000002367 halogens Chemical class 0.000 claims 20
125000000168 pyrrolyl group Chemical group 0.000 claims 20
125000001544 thienyl group Chemical group 0.000 claims 20
125000006729 (C2-C5) alkenyl group Chemical group 0.000 claims 18
125000006730 (C2-C5) alkynyl group Chemical group 0.000 claims 18
125000002947 alkylene group Chemical group 0.000 claims 18
150000001721 carbon Chemical group 0.000 claims 18
125000002541 furyl group Chemical group 0.000 claims 18
125000002883 imidazolyl group Chemical group 0.000 claims 18
125000001786 isothiazolyl group Chemical group 0.000 claims 18
125000000842 isoxazolyl group Chemical group 0.000 claims 18
125000001715 oxadiazolyl group Chemical group 0.000 claims 18
125000002971 oxazolyl group Chemical group 0.000 claims 18
125000003226 pyrazolyl group Chemical group 0.000 claims 18
125000001113 thiadiazolyl group Chemical group 0.000 claims 18
125000000335 thiazolyl group Chemical group 0.000 claims 18
125000004093 cyano group Chemical group *C#N 0.000 claims 17
125000003545 alkoxy group Chemical group 0.000 claims 16
125000006528 (C2-C6) alkyl group Chemical group 0.000 claims 15
125000002619 bicyclic group Chemical group 0.000 claims 15
125000002887 hydroxy group Chemical group [H]O* 0.000 claims 15
125000003709 fluoroalkyl group Chemical group 0.000 claims 14
125000000719 pyrrolidinyl group Chemical group 0.000 claims 14
125000001424 substituent group Chemical group 0.000 claims 14
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 12
125000001769 aryl amino group Chemical group 0.000 claims 12
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 12
239000001301 oxygen Substances 0.000 claims 12
125000002294 quinazolinyl group Chemical group N1=C(N=CC2=CC=CC=C12)* 0.000 claims 12
239000011593 sulfur Substances 0.000 claims 12
125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 claims 11
125000003373 pyrazinyl group Chemical group 0.000 claims 11
125000003831 tetrazolyl group Chemical group 0.000 claims 11
125000002733 (C1-C6) fluoroalkyl group Chemical group 0.000 claims 10
125000002837 carbocyclic group Chemical group 0.000 claims 10
125000005844 heterocyclyloxy group Chemical group 0.000 claims 10
125000004594 isoindolinyl group Chemical group C1(NCC2=CC=CC=C12)* 0.000 claims 10
125000003386 piperidinyl group Chemical group 0.000 claims 10
125000004183 alkoxy alkyl group Chemical group 0.000 claims 9
125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 claims 9
125000005605 benzo group Chemical group 0.000 claims 9
125000003310 benzodiazepinyl group Chemical group N1N=C(C=CC2=C1C=CC=C2)* 0.000 claims 9
125000001164 benzothiazolyl group Chemical group S1C(=NC2=C1C=CC=C2)* 0.000 claims 9
125000004541 benzoxazolyl group Chemical group O1C(=NC2=C1C=CC=C2)* 0.000 claims 9
125000000259 cinnolinyl group Chemical group N1=NC(=CC2=CC=CC=C12)* 0.000 claims 9
125000005044 dihydroquinolinyl group Chemical group N1(CC=CC2=CC=CC=C12)* 0.000 claims 9
125000002768 hydroxyalkyl group Chemical group 0.000 claims 9
125000003387 indolinyl group Chemical group N1(CCC2=CC=CC=C12)* 0.000 claims 9
125000000904 isoindolyl group Chemical group C=1(NC=C2C=CC=CC12)* 0.000 claims 9
125000004433 nitrogen atom Chemical group N* 0.000 claims 9
125000004592 phthalazinyl group Chemical group C1(=NN=CC2=CC=CC=C12)* 0.000 claims 9
125000005545 phthalimidyl group Chemical group 0.000 claims 9
125000000561 purinyl group Chemical group N1=C(N=C2N=CNC2=C1)* 0.000 claims 9
125000003039 tetrahydroisoquinolinyl group Chemical group C1(NCCC2=CC=CC=C12)* 0.000 claims 9
125000000147 tetrahydroquinolinyl group Chemical group N1(CCCC2=CC=CC=C12)* 0.000 claims 9
125000001425 triazolyl group Chemical group 0.000 claims 9
125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 8
MZAGXDHQGXUDDX-JSRXJHBZSA-N (e,2z)-4-ethyl-2-hydroxyimino-5-nitrohex-3-enamide Chemical compound [O-][N+](=O)C(C)C(/CC)=C/C(=N/O)/C(N)=O MZAGXDHQGXUDDX-JSRXJHBZSA-N 0.000 claims 8
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 8
101100134927 Gallus gallus COR8 gene Proteins 0.000 claims 8
101100533890 Hypocrea jecorina (strain QM6a) sor3 gene Proteins 0.000 claims 8
101100533874 Hypocrea jecorina (strain QM6a) sor5 gene Proteins 0.000 claims 8
125000000499 benzofuranyl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 claims 8
125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 claims 8
125000004122 cyclic group Chemical group 0.000 claims 8
125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 8
125000004857 imidazopyridinyl group Chemical group N1C(=NC2=C1C=CC=N2)* 0.000 claims 8
125000003453 indazolyl group Chemical group N1N=C(C2=C1C=CC=C2)* 0.000 claims 8
125000002183 isoquinolinyl group Chemical group C1(=NC=CC2=CC=CC=C12)* 0.000 claims 8
125000002757 morpholinyl group Chemical group 0.000 claims 8
125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 claims 8
125000001567 quinoxalinyl group Chemical group N1=C(C=NC2=CC=CC=C12)* 0.000 claims 8
YBYIRNPNPLQARY-UHFFFAOYSA-N 1H-indene Natural products C1=CC=C2CC=CC2=C1 YBYIRNPNPLQARY-UHFFFAOYSA-N 0.000 claims 7
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 7
125000003392 indanyl group Chemical group C1(CCC2=CC=CC=C12)* 0.000 claims 7
125000003454 indenyl group Chemical group C1(C=CC2=CC=CC=C12)* 0.000 claims 7
125000001041 indolyl group Chemical group 0.000 claims 7
125000002098 pyridazinyl group Chemical group 0.000 claims 7
229920006395 saturated elastomer Polymers 0.000 claims 7
125000004306 triazinyl group Chemical group 0.000 claims 7
125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 6
125000006274 (C1-C3)alkoxy group Chemical group 0.000 claims 6
UWYZHKAOTLEWKK-UHFFFAOYSA-N 1,2,3,4-tetrahydroisoquinoline Chemical compound C1=CC=C2CNCCC2=C1 UWYZHKAOTLEWKK-UHFFFAOYSA-N 0.000 claims 6
KYXSVGVQGFPNRQ-UHFFFAOYSA-N 2-methyl-3,4-dihydro-1h-isoquinoline Chemical compound C1=CC=C2CN(C)CCC2=C1 KYXSVGVQGFPNRQ-UHFFFAOYSA-N 0.000 claims 6
HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims 6
125000002785 azepinyl group Chemical group 0.000 claims 6
125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 6
125000004432 carbon atom Chemical group C* 0.000 claims 6
239000000460 chlorine Substances 0.000 claims 6
229910052801 chlorine Inorganic materials 0.000 claims 6
125000000753 cycloalkyl group Chemical group 0.000 claims 6
125000002576 diazepinyl group Chemical group N1N=C(C=CC=C1)* 0.000 claims 6
125000001153 fluoro group Chemical group F* 0.000 claims 6
125000005241 heteroarylamino group Chemical group 0.000 claims 6
125000005553 heteroaryloxy group Chemical group 0.000 claims 6
150000004677 hydrates Chemical class 0.000 claims 6
PXZQEOJJUGGUIB-UHFFFAOYSA-N isoindolin-1-one Chemical compound C1=CC=C2C(=O)NCC2=C1 PXZQEOJJUGGUIB-UHFFFAOYSA-N 0.000 claims 6
125000000160 oxazolidinyl group Chemical group 0.000 claims 6
125000005968 oxazolinyl group Chemical group 0.000 claims 6
125000003585 oxepinyl group Chemical group 0.000 claims 6
125000003566 oxetanyl group Chemical group 0.000 claims 6
125000004043 oxo group Chemical group O=* 0.000 claims 6
125000004193 piperazinyl group Chemical group 0.000 claims 6
239000000651 prodrug Substances 0.000 claims 6
229940002612 prodrug Drugs 0.000 claims 6
125000004309 pyranyl group Chemical group O1C(C=CC=C1)* 0.000 claims 6
150000003839 salts Chemical class 0.000 claims 6
125000006296 sulfonyl amino group Chemical group [H]N(*)S(*)(=O)=O 0.000 claims 6
125000003718 tetrahydrofuranyl group Chemical group 0.000 claims 6
125000001412 tetrahydropyranyl group Chemical group 0.000 claims 6
125000004568 thiomorpholinyl group Chemical group 0.000 claims 6
WTKZEGDFNFYCGP-UHFFFAOYSA-N Pyrazole Chemical compound C=1C=NNC=1 WTKZEGDFNFYCGP-UHFFFAOYSA-N 0.000 claims 5
JQPJCPJUEYREHV-UHFFFAOYSA-N n-propan-2-ylpyridin-2-amine Chemical compound CC(C)NC1=CC=CC=N1 JQPJCPJUEYREHV-UHFFFAOYSA-N 0.000 claims 5
125000001712 tetrahydronaphthyl group Chemical group C1(CCCC2=CC=CC=C12)* 0.000 claims 5
ZXOXPYYAVFDCDK-UHFFFAOYSA-N 2-(1h-pyrazol-4-yl)pyridine Chemical compound C1=NNC=C1C1=CC=CC=N1 ZXOXPYYAVFDCDK-UHFFFAOYSA-N 0.000 claims 4
CGWOEOXQHIMZEQ-UHFFFAOYSA-N 3-[1-[[4-(2-phenylquinolin-3-yl)phenyl]methyl]piperidin-4-yl]-1h-benzimidazol-2-one Chemical compound OC1=NC2=CC=CC=C2N1C(CC1)CCN1CC(C=C1)=CC=C1C1=CC2=CC=CC=C2N=C1C1=CC=CC=C1 CGWOEOXQHIMZEQ-UHFFFAOYSA-N 0.000 claims 4
101100294115 Caenorhabditis elegans nhr-4 gene Proteins 0.000 claims 4
101100533888 Hypocrea jecorina (strain QM6a) sor4 gene Proteins 0.000 claims 4
101100533877 Hypocrea jecorina (strain QM6a) sor8 gene Proteins 0.000 claims 4
UQFQONCQIQEYPJ-UHFFFAOYSA-N N-methylpyrazole Chemical compound CN1C=CC=N1 UQFQONCQIQEYPJ-UHFFFAOYSA-N 0.000 claims 4
125000001309 chloro group Chemical group Cl* 0.000 claims 4
ZXEKIIBDNHEJCQ-UHFFFAOYSA-N iso-butyl alcohol Natural products CC(C)CO ZXEKIIBDNHEJCQ-UHFFFAOYSA-N 0.000 claims 4
BAXOFTOLAUCFNW-UHFFFAOYSA-N 1H-indazole Chemical compound C1=CC=C2C=NNC2=C1 BAXOFTOLAUCFNW-UHFFFAOYSA-N 0.000 claims 3
125000004180 3-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(F)=C1[H] 0.000 claims 3
125000004801 4-cyanophenyl group Chemical group [H]C1=C([H])C(C#N)=C([H])C([H])=C1* 0.000 claims 3
SMWDFEZZVXVKRB-UHFFFAOYSA-N Quinoline Chemical compound N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 claims 3
125000003710 aryl alkyl group Chemical group 0.000 claims 3
125000004604 benzisothiazolyl group Chemical group S1N=C(C2=C1C=CC=C2)* 0.000 claims 3
125000004603 benzisoxazolyl group Chemical group O1N=C(C2=C1C=CC=C2)* 0.000 claims 3
125000004446 heteroarylalkyl group Chemical group 0.000 claims 3
125000000336 imidazol-5-yl group Chemical group [H]N1C([H])=NC([H])=C1[*] 0.000 claims 3
125000004499 isoxazol-5-yl group Chemical group O1N=CC=C1* 0.000 claims 3
HXXAUIXTYRHFNO-UHFFFAOYSA-N n-methylpyridine-2-carboxamide Chemical compound CNC(=O)C1=CC=CC=N1 HXXAUIXTYRHFNO-UHFFFAOYSA-N 0.000 claims 3
VWJMXGHSQCIPPX-UHFFFAOYSA-N n-pyridin-2-ylmethanesulfonamide Chemical compound CS(=O)(=O)NC1=CC=CC=N1 VWJMXGHSQCIPPX-UHFFFAOYSA-N 0.000 claims 3
125000004550 quinolin-6-yl group Chemical group N1=CC=CC2=CC(=CC=C12)* 0.000 claims 3
125000003107 substituted aryl group Chemical group 0.000 claims 3
HHVIBTZHLRERCL-UHFFFAOYSA-N sulfonyldimethane Chemical compound CS(C)(=O)=O HHVIBTZHLRERCL-UHFFFAOYSA-N 0.000 claims 3
KTZQTRPPVKQPFO-UHFFFAOYSA-N 1,2-benzoxazole Chemical compound C1=CC=C2C=NOC2=C1 KTZQTRPPVKQPFO-UHFFFAOYSA-N 0.000 claims 2
MQFWUBIFAPGPTD-UHFFFAOYSA-N 1-(5-tert-butyl-2-quinazolin-6-ylpyrazol-3-yl)-3-[2-fluoro-5-[8-methyl-2-(methylamino)-7-oxopyrido[2,3-d]pyrimidin-6-yl]phenyl]urea Chemical compound N1=CN=CC2=CC(N3N=C(C=C3NC(=O)NC=3C(F)=CC=C(C=3)C3=CC4=CN=C(N=C4N(C)C3=O)NC)C(C)(C)C)=CC=C21 MQFWUBIFAPGPTD-UHFFFAOYSA-N 0.000 claims 2
UFRDABRESZTDFV-UHFFFAOYSA-N 1-[2-tert-butyl-4-(3-fluorophenyl)pyrimidin-5-yl]-3-[3-[8-methyl-2-(methylamino)-7-oxopyrido[2,3-d]pyrimidin-6-yl]phenyl]urea Chemical compound O=C1N(C)C2=NC(NC)=NC=C2C=C1C(C=1)=CC=CC=1NC(=O)NC1=CN=C(C(C)(C)C)N=C1C1=CC=CC(F)=C1 UFRDABRESZTDFV-UHFFFAOYSA-N 0.000 claims 2
QCHWBSOCXGWYHC-UHFFFAOYSA-N 1-[3-[8-methyl-2-(methylamino)-7-oxopyrido[2,3-d]pyrimidin-6-yl]phenyl]-3-(2-propan-2-yl-4-pyridin-3-ylpyrimidin-5-yl)urea Chemical compound O=C1N(C)C2=NC(NC)=NC=C2C=C1C(C=1)=CC=CC=1NC(=O)NC1=CN=C(C(C)C)N=C1C1=CC=CN=C1 QCHWBSOCXGWYHC-UHFFFAOYSA-N 0.000 claims 2
HBYDOQYKBGVGNL-UHFFFAOYSA-N 1-[5-tert-butyl-2-(1h-pyrazol-4-yl)pyrazol-3-yl]-3-[3-[8-methyl-2-(methylamino)-7-oxopyrido[2,3-d]pyrimidin-6-yl]phenyl]urea Chemical compound O=C1N(C)C2=NC(NC)=NC=C2C=C1C(C=1)=CC=CC=1NC(=O)NC1=CC(C(C)(C)C)=NN1C=1C=NNC=1 HBYDOQYKBGVGNL-UHFFFAOYSA-N 0.000 claims 2
IELZFJBBJXHQIN-UHFFFAOYSA-N 2-(1-methylpyrazol-4-yl)pyridine Chemical compound C1=NN(C)C=C1C1=CC=CC=N1 IELZFJBBJXHQIN-UHFFFAOYSA-N 0.000 claims 2
125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 claims 2
SOIMEQWMDFOVEP-UHFFFAOYSA-N 4-[4-[(5-tert-butyl-2-isoquinolin-6-ylpyrazol-3-yl)carbamoylamino]-3-fluorophenoxy]-n-methylpyridine-2-carboxamide Chemical compound C1=NC(C(=O)NC)=CC(OC=2C=C(F)C(NC(=O)NC=3N(N=C(C=3)C(C)(C)C)C=3C=C4C=CN=CC4=CC=3)=CC=2)=C1 SOIMEQWMDFOVEP-UHFFFAOYSA-N 0.000 claims 2
125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 claims 2
UBXXXBYLDPJPAZ-UHFFFAOYSA-N 8-methyl-2-(methylamino)pyrido[2,3-d]pyrimidin-7-one Chemical compound C1=CC(=O)N(C)C2=NC(NC)=NC=C21 UBXXXBYLDPJPAZ-UHFFFAOYSA-N 0.000 claims 2
JRLTTZUODKEYDH-UHFFFAOYSA-N 8-methylquinoline Chemical group C1=CN=C2C(C)=CC=CC2=C1 JRLTTZUODKEYDH-UHFFFAOYSA-N 0.000 claims 2
ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical group [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 2
LAFCTVKUQKRJSZ-UHFFFAOYSA-N [N]C1=CC=CN1 Chemical compound [N]C1=CC=CN1 LAFCTVKUQKRJSZ-UHFFFAOYSA-N 0.000 claims 2
125000003368 amide group Chemical group 0.000 claims 2
125000003943 azolyl group Chemical group 0.000 claims 2
AWJUIBRHMBBTKR-UHFFFAOYSA-N isoquinoline Chemical compound C1=NC=CC2=CC=CC=C21 AWJUIBRHMBBTKR-UHFFFAOYSA-N 0.000 claims 2
QROKOTBWFZITJZ-UHFFFAOYSA-N n-pyridin-2-ylacetamide Chemical compound CC(=O)NC1=CC=CC=N1 QROKOTBWFZITJZ-UHFFFAOYSA-N 0.000 claims 2
NRNCYVBFPDDJNE-UHFFFAOYSA-N pemoline Chemical compound O1C(N)=NC(=O)C1C1=CC=CC=C1 NRNCYVBFPDDJNE-UHFFFAOYSA-N 0.000 claims 2
210000002700 urine Anatomy 0.000 claims 2
GNCYAYSLWAPVMU-UHFFFAOYSA-N (5-propan-2-yl-2-pyridin-3-ylpyrazol-3-yl)urea Chemical compound C(C)(C)C1=NN(C(=C1)NC(=O)N)C=1C=NC=CC=1 GNCYAYSLWAPVMU-UHFFFAOYSA-N 0.000 claims 1
BCMCBBGGLRIHSE-UHFFFAOYSA-N 1,3-benzoxazole Chemical compound C1=CC=C2OC=NC2=C1 BCMCBBGGLRIHSE-UHFFFAOYSA-N 0.000 claims 1
HYHJQUMQEPNWFD-UHFFFAOYSA-N 1-(1-tert-butyl-3-isoquinolin-6-ylpyrazol-4-yl)-3-[2-fluoro-4-(1-oxo-2,3-dihydroisoindol-4-yl)phenyl]urea Chemical compound C1=NC=CC2=CC(C=3C(NC(=O)NC=4C(=CC(=CC=4)C=4C=5CNC(=O)C=5C=CC=4)F)=CN(N=3)C(C)(C)C)=CC=C21 HYHJQUMQEPNWFD-UHFFFAOYSA-N 0.000 claims 1
SMKVBYUPPGIBAR-UHFFFAOYSA-N 1-(1-tert-butyl-3-isoquinolin-6-ylpyrazol-4-yl)-3-[4-(1-oxo-2,3-dihydroisoindol-4-yl)phenyl]urea Chemical compound C1=NC=CC2=CC(C=3C(NC(=O)NC=4C=CC(=CC=4)C=4C=5CNC(=O)C=5C=CC=4)=CN(N=3)C(C)(C)C)=CC=C21 SMKVBYUPPGIBAR-UHFFFAOYSA-N 0.000 claims 1
WGZXPXHIAHPVJZ-UHFFFAOYSA-N 1-(1-tert-butyl-3-isoquinolin-6-ylpyrazol-4-yl)-3-[4-[2-(methanesulfonamido)pyridin-4-yl]oxyphenyl]urea Chemical compound C=1C=C2C=NC=CC2=CC=1C1=NN(C(C)(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC1=CC=NC(NS(C)(=O)=O)=C1 WGZXPXHIAHPVJZ-UHFFFAOYSA-N 0.000 claims 1
UEVCMAWFKNXVCG-UHFFFAOYSA-N 1-(1-tert-butyl-3-phenylpyrazol-4-yl)-3-[3-[2-(methylamino)-7-oxo-8-propan-2-ylpyrido[2,3-d]pyrimidin-6-yl]phenyl]urea Chemical compound O=C1N(C(C)C)C2=NC(NC)=NC=C2C=C1C(C=1)=CC=CC=1NC(=O)NC1=CN(C(C)(C)C)N=C1C1=CC=CC=C1 UEVCMAWFKNXVCG-UHFFFAOYSA-N 0.000 claims 1
OTYXKKQITHGSAC-UHFFFAOYSA-N 1-(1-tert-butyl-3-phenylpyrazol-4-yl)-3-[3-[8-methyl-2-(methylamino)-7-oxopyrido[2,3-d]pyrimidin-6-yl]phenyl]urea Chemical compound O=C1N(C)C2=NC(NC)=NC=C2C=C1C(C=1)=CC=CC=1NC(=O)NC1=CN(C(C)(C)C)N=C1C1=CC=CC=C1 OTYXKKQITHGSAC-UHFFFAOYSA-N 0.000 claims 1
VTVQNTSURXBQFD-UHFFFAOYSA-N 1-(1-tert-butyl-3-pyridin-3-ylpyrazol-4-yl)-3-[2-fluoro-4-(1-oxo-2,3-dihydroisoindol-4-yl)phenyl]urea Chemical compound N=1N(C(C)(C)C)C=C(NC(=O)NC=2C(=CC(=CC=2)C=2C=3CNC(=O)C=3C=CC=2)F)C=1C1=CC=CN=C1 VTVQNTSURXBQFD-UHFFFAOYSA-N 0.000 claims 1
WDVJAFTUUCDCFF-UHFFFAOYSA-N 1-(1-tert-butyl-3-quinazolin-6-ylpyrazol-4-yl)-3-(2,3-dichlorophenyl)urea Chemical compound C=1C=C2N=CN=CC2=CC=1C1=NN(C(C)(C)C)C=C1NC(=O)NC1=CC=CC(Cl)=C1Cl WDVJAFTUUCDCFF-UHFFFAOYSA-N 0.000 claims 1
QOWYYGAYFUCDCC-UHFFFAOYSA-N 1-(1-tert-butyl-3-quinazolin-6-ylpyrazol-4-yl)-3-[2-fluoro-4-[2-(1-methylpyrazol-4-yl)pyridin-4-yl]oxyphenyl]urea Chemical compound C1=NN(C)C=C1C1=CC(OC=2C=C(F)C(NC(=O)NC=3C(=NN(C=3)C(C)(C)C)C=3C=C4C=NC=NC4=CC=3)=CC=2)=CC=N1 QOWYYGAYFUCDCC-UHFFFAOYSA-N 0.000 claims 1
JRKBZJGVRZTZFX-UHFFFAOYSA-N 1-(1-tert-butyl-3-quinazolin-6-ylpyrazol-4-yl)-3-[4-[2-(1h-pyrazol-4-yl)pyridin-4-yl]oxyphenyl]urea Chemical compound C=1C=C2N=CN=CC2=CC=1C1=NN(C(C)(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC(C=1)=CC=NC=1C=1C=NNC=1 JRKBZJGVRZTZFX-UHFFFAOYSA-N 0.000 claims 1
CFUHIGRZRSUGIM-UHFFFAOYSA-N 1-(1-tert-butyl-3-quinolin-6-ylpyrazol-4-yl)-3-[2-fluoro-4-[2-(methanesulfonamido)pyridin-4-yl]oxyphenyl]urea Chemical compound C=1C=C2N=CC=CC2=CC=1C1=NN(C(C)(C)C)C=C1NC(=O)NC(C(=C1)F)=CC=C1OC1=CC=NC(NS(C)(=O)=O)=C1 CFUHIGRZRSUGIM-UHFFFAOYSA-N 0.000 claims 1
VUDHGSWNMWLMKS-UHFFFAOYSA-N 1-(2-ethyl-4-pyridin-3-ylpyrimidin-5-yl)-3-[2-fluoro-5-[2-(methylamino)-7-oxo-8-propan-2-ylpyrido[2,3-d]pyrimidin-6-yl]phenyl]urea Chemical compound N=1C(CC)=NC=C(NC(=O)NC=2C(=CC=C(C=2)C=2C(N(C(C)C)C3=NC(NC)=NC=C3C=2)=O)F)C=1C1=CC=CN=C1 VUDHGSWNMWLMKS-UHFFFAOYSA-N 0.000 claims 1
QPFRLQIDZKHFFE-UHFFFAOYSA-N 1-(2-ethyl-4-pyridin-3-ylpyrimidin-5-yl)-3-[3-[8-methyl-2-(methylamino)-7-oxopyrido[2,3-d]pyrimidin-6-yl]phenyl]urea Chemical compound N=1C(CC)=NC=C(NC(=O)NC=2C=C(C=CC=2)C=2C(N(C)C3=NC(NC)=NC=C3C=2)=O)C=1C1=CC=CN=C1 QPFRLQIDZKHFFE-UHFFFAOYSA-N 0.000 claims 1
KVRVCDXYEQZKFI-UHFFFAOYSA-N 1-(2-isoquinolin-6-yl-5-propan-2-ylpyrazol-3-yl)-3-[4-[2-(1h-pyrazol-4-yl)pyridin-4-yl]oxyphenyl]urea Chemical compound C=1C=C2C=NC=CC2=CC=1N1N=C(C(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC(C=1)=CC=NC=1C=1C=NNC=1 KVRVCDXYEQZKFI-UHFFFAOYSA-N 0.000 claims 1
DHBCVEPVCHMGAC-UHFFFAOYSA-N 1-(2-isoquinolin-6-yl-5-propan-2-ylpyrazol-3-yl)-3-[4-[2-(methanesulfonamido)pyridin-4-yl]oxyphenyl]urea Chemical compound C=1C=C2C=NC=CC2=CC=1N1N=C(C(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC1=CC=NC(NS(C)(=O)=O)=C1 DHBCVEPVCHMGAC-UHFFFAOYSA-N 0.000 claims 1
RWGCLLANRXQBIZ-UHFFFAOYSA-N 1-(2-isoquinolin-6-yl-5-propan-2-ylpyrazol-3-yl)-3-[4-[2-(propan-2-ylamino)pyridin-4-yl]oxyphenyl]urea Chemical compound C1=NC(NC(C)C)=CC(OC=2C=CC(NC(=O)NC=3N(N=C(C=3)C(C)C)C=3C=C4C=CN=CC4=CC=3)=CC=2)=C1 RWGCLLANRXQBIZ-UHFFFAOYSA-N 0.000 claims 1
MOBSVQGFAQPENN-UHFFFAOYSA-N 1-(2-tert-butyl-4-morpholin-4-ylpyrimidin-5-yl)-3-[3-[8-methyl-2-(methylamino)-7-oxopyrido[2,3-d]pyrimidin-6-yl]phenyl]urea Chemical compound O=C1N(C)C2=NC(NC)=NC=C2C=C1C(C=1)=CC=CC=1NC(=O)NC1=CN=C(C(C)(C)C)N=C1N1CCOCC1 MOBSVQGFAQPENN-UHFFFAOYSA-N 0.000 claims 1
GHNPWIQEGLPGJJ-UHFFFAOYSA-N 1-(2-tert-butyl-4-pyridin-3-ylpyrimidin-5-yl)-3-[3-[8-methyl-2-(methylamino)-7-oxopyrido[2,3-d]pyrimidin-6-yl]phenyl]urea Chemical compound O=C1N(C)C2=NC(NC)=NC=C2C=C1C(C=1)=CC=CC=1NC(=O)NC1=CN=C(C(C)(C)C)N=C1C1=CC=CN=C1 GHNPWIQEGLPGJJ-UHFFFAOYSA-N 0.000 claims 1
MKGOZHCMEDKNSC-UHFFFAOYSA-N 1-(2-tert-butyl-4-quinolin-6-ylpyrimidin-5-yl)-3-[4-fluoro-3-[8-methyl-2-(methylamino)-7-oxopyrido[2,3-d]pyrimidin-6-yl]phenyl]urea Chemical compound N1=CC=CC2=CC(C3=NC(=NC=C3NC(=O)NC=3C=C(C(=CC=3)F)C3=CC4=CN=C(N=C4N(C)C3=O)NC)C(C)(C)C)=CC=C21 MKGOZHCMEDKNSC-UHFFFAOYSA-N 0.000 claims 1
YDEZQDKHSPSGIU-UHFFFAOYSA-N 1-(3-isoquinolin-6-yl-1-propan-2-ylpyrazol-4-yl)-3-[4-[2-(1-methylpyrazol-4-yl)pyridin-4-yl]oxyphenyl]urea Chemical compound C=1C=C2C=NC=CC2=CC=1C1=NN(C(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC(C=1)=CC=NC=1C=1C=NN(C)C=1 YDEZQDKHSPSGIU-UHFFFAOYSA-N 0.000 claims 1
JPVWGENTZFISLK-UHFFFAOYSA-N 1-(3-isoquinolin-6-yl-1-propan-2-ylpyrazol-4-yl)-3-[4-[2-(1h-pyrazol-4-yl)pyridin-4-yl]oxyphenyl]urea Chemical compound C=1C=C2C=NC=CC2=CC=1C1=NN(C(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC(C=1)=CC=NC=1C=1C=NNC=1 JPVWGENTZFISLK-UHFFFAOYSA-N 0.000 claims 1
UUIITUMFUWDQSV-UHFFFAOYSA-N 1-(5-propan-2-yl-2-quinolin-6-ylpyrazol-3-yl)-3-[4-[2-(1h-pyrazol-4-yl)pyridin-4-yl]oxyphenyl]urea Chemical compound C=1C=C2N=CC=CC2=CC=1N1N=C(C(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC(C=1)=CC=NC=1C=1C=NNC=1 UUIITUMFUWDQSV-UHFFFAOYSA-N 0.000 claims 1
GYZLRVMYQPRIBK-UHFFFAOYSA-N 1-(5-tert-butyl-2-isoquinolin-6-ylpyrazol-3-yl)-3-(2,3-dichlorophenyl)urea Chemical compound C=1C=C2C=NC=CC2=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)NC1=CC=CC(Cl)=C1Cl GYZLRVMYQPRIBK-UHFFFAOYSA-N 0.000 claims 1
CWKZSWAAUXQPEE-UHFFFAOYSA-N 1-(5-tert-butyl-2-isoquinolin-6-ylpyrazol-3-yl)-3-[2-fluoro-4-[2-(1-methylpyrazol-4-yl)pyridin-4-yl]oxyphenyl]urea Chemical compound C1=NN(C)C=C1C1=CC(OC=2C=C(F)C(NC(=O)NC=3N(N=C(C=3)C(C)(C)C)C=3C=C4C=CN=CC4=CC=3)=CC=2)=CC=N1 CWKZSWAAUXQPEE-UHFFFAOYSA-N 0.000 claims 1
OTRIJCLAWZWJST-UHFFFAOYSA-N 1-(5-tert-butyl-2-isoquinolin-6-ylpyrazol-3-yl)-3-[2-fluoro-4-[2-(1h-pyrazol-4-yl)pyridin-4-yl]oxyphenyl]urea Chemical compound C=1C=C2C=NC=CC2=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)NC(C(=C1)F)=CC=C1OC(C=1)=CC=NC=1C=1C=NNC=1 OTRIJCLAWZWJST-UHFFFAOYSA-N 0.000 claims 1
SHMSPXDCIPRFLG-UHFFFAOYSA-N 1-(5-tert-butyl-2-isoquinolin-6-ylpyrazol-3-yl)-3-[2-fluoro-4-[2-(methanesulfonamido)pyridin-4-yl]oxyphenyl]urea Chemical compound C=1C=C2C=NC=CC2=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)NC(C(=C1)F)=CC=C1OC1=CC=NC(NS(C)(=O)=O)=C1 SHMSPXDCIPRFLG-UHFFFAOYSA-N 0.000 claims 1
KTZUSQQVOWSENL-UHFFFAOYSA-N 1-(5-tert-butyl-2-isoquinolin-6-ylpyrazol-3-yl)-3-[2-fluoro-4-[2-(propan-2-ylamino)pyridin-4-yl]oxyphenyl]urea Chemical compound C1=NC(NC(C)C)=CC(OC=2C=C(F)C(NC(=O)NC=3N(N=C(C=3)C(C)(C)C)C=3C=C4C=CN=CC4=CC=3)=CC=2)=C1 KTZUSQQVOWSENL-UHFFFAOYSA-N 0.000 claims 1
QSVRLQOLEJTWBO-UHFFFAOYSA-N 1-(5-tert-butyl-2-isoquinolin-6-ylpyrazol-3-yl)-3-[2-fluoro-5-(1-oxo-2,3-dihydroisoindol-4-yl)phenyl]urea Chemical compound C1=NC=CC2=CC(N3C(NC(=O)NC=4C(=CC=C(C=4)C=4C=5CNC(=O)C=5C=CC=4)F)=CC(=N3)C(C)(C)C)=CC=C21 QSVRLQOLEJTWBO-UHFFFAOYSA-N 0.000 claims 1
KCJCUOVXTVRTNY-UHFFFAOYSA-N 1-(5-tert-butyl-2-isoquinolin-6-ylpyrazol-3-yl)-3-[3-(1-oxo-2,3-dihydroisoindol-4-yl)phenyl]urea Chemical compound C1=NC=CC2=CC(N3C(NC(=O)NC=4C=C(C=CC=4)C=4C=5CNC(=O)C=5C=CC=4)=CC(=N3)C(C)(C)C)=CC=C21 KCJCUOVXTVRTNY-UHFFFAOYSA-N 0.000 claims 1
URIRLEVFANTFBJ-UHFFFAOYSA-N 1-(5-tert-butyl-2-isoquinolin-6-ylpyrazol-3-yl)-3-[4-(1-oxo-2,3-dihydroisoindol-4-yl)phenyl]urea Chemical compound C1=NC=CC2=CC(N3C(NC(=O)NC=4C=CC(=CC=4)C=4C=5CNC(=O)C=5C=CC=4)=CC(=N3)C(C)(C)C)=CC=C21 URIRLEVFANTFBJ-UHFFFAOYSA-N 0.000 claims 1
JVVSTDJUPOQPJE-UHFFFAOYSA-N 1-(5-tert-butyl-2-isoquinolin-6-ylpyrazol-3-yl)-3-[4-[2-(1-methylpyrazol-4-yl)pyridin-4-yl]oxyphenyl]urea Chemical compound C1=NN(C)C=C1C1=CC(OC=2C=CC(NC(=O)NC=3N(N=C(C=3)C(C)(C)C)C=3C=C4C=CN=CC4=CC=3)=CC=2)=CC=N1 JVVSTDJUPOQPJE-UHFFFAOYSA-N 0.000 claims 1
GSJKAUXMCOXQDE-UHFFFAOYSA-N 1-(5-tert-butyl-2-phenylpyrazol-3-yl)-3-[2-fluoro-5-[8-methyl-2-(methylamino)-7-oxopyrido[2,3-d]pyrimidin-6-yl]phenyl]urea Chemical compound O=C1N(C)C2=NC(NC)=NC=C2C=C1C(C=1)=CC=C(F)C=1NC(=O)NC1=CC(C(C)(C)C)=NN1C1=CC=CC=C1 GSJKAUXMCOXQDE-UHFFFAOYSA-N 0.000 claims 1
TVUVDRYLUPFDDH-UHFFFAOYSA-N 1-(5-tert-butyl-2-phenylpyrazol-3-yl)-3-[3-[2-(methylamino)-7-oxo-8-propan-2-ylpyrido[2,3-d]pyrimidin-6-yl]phenyl]urea Chemical compound O=C1N(C(C)C)C2=NC(NC)=NC=C2C=C1C(C=1)=CC=CC=1NC(=O)NC1=CC(C(C)(C)C)=NN1C1=CC=CC=C1 TVUVDRYLUPFDDH-UHFFFAOYSA-N 0.000 claims 1
OUGYIPQFIMHVTK-UHFFFAOYSA-N 1-(5-tert-butyl-2-phenylpyrazol-3-yl)-3-[3-[8-(1-hydroxy-2-methylpropan-2-yl)-2-(methylamino)-7-oxopyrido[2,3-d]pyrimidin-6-yl]phenyl]urea Chemical compound O=C1N(C(C)(C)CO)C2=NC(NC)=NC=C2C=C1C(C=1)=CC=CC=1NC(=O)NC1=CC(C(C)(C)C)=NN1C1=CC=CC=C1 OUGYIPQFIMHVTK-UHFFFAOYSA-N 0.000 claims 1
OFPKZOXDVHCZMP-UHFFFAOYSA-N 1-(5-tert-butyl-2-phenylpyrazol-3-yl)-3-[3-[8-methyl-2-(methylamino)-7-oxopyrido[2,3-d]pyrimidin-6-yl]phenyl]urea Chemical compound O=C1N(C)C2=NC(NC)=NC=C2C=C1C(C=1)=CC=CC=1NC(=O)NC1=CC(C(C)(C)C)=NN1C1=CC=CC=C1 OFPKZOXDVHCZMP-UHFFFAOYSA-N 0.000 claims 1
OVLBPIYCBYRXCX-UHFFFAOYSA-N 1-(5-tert-butyl-2-pyridin-3-ylpyrazol-3-yl)-3-[2-fluoro-4-(1-oxo-2,3-dihydroisoindol-4-yl)phenyl]urea Chemical compound N1=C(C(C)(C)C)C=C(NC(=O)NC=2C(=CC(=CC=2)C=2C=3CNC(=O)C=3C=CC=2)F)N1C1=CC=CN=C1 OVLBPIYCBYRXCX-UHFFFAOYSA-N 0.000 claims 1
QTTFYBKQWIOAMX-UHFFFAOYSA-N 1-(5-tert-butyl-2-pyridin-3-ylpyrazol-3-yl)-3-[2-fluoro-4-methyl-5-[2-(methylamino)-7-oxo-8-propan-2-ylpyrido[2,3-d]pyrimidin-6-yl]phenyl]urea Chemical compound O=C1N(C(C)C)C2=NC(NC)=NC=C2C=C1C(C(=CC=1F)C)=CC=1NC(=O)NC1=CC(C(C)(C)C)=NN1C1=CC=CN=C1 QTTFYBKQWIOAMX-UHFFFAOYSA-N 0.000 claims 1
XKHLMTIZCMNJHT-UHFFFAOYSA-N 1-(5-tert-butyl-2-pyridin-3-ylpyrazol-3-yl)-3-[2-fluoro-5-(1-oxo-2,3-dihydroisoindol-4-yl)phenyl]urea Chemical compound N1=C(C(C)(C)C)C=C(NC(=O)NC=2C(=CC=C(C=2)C=2C=3CNC(=O)C=3C=CC=2)F)N1C1=CC=CN=C1 XKHLMTIZCMNJHT-UHFFFAOYSA-N 0.000 claims 1
ZJDVUISBPLZXRQ-UHFFFAOYSA-N 1-(5-tert-butyl-2-pyridin-3-ylpyrazol-3-yl)-3-[2-fluoro-5-[8-methyl-2-(methylamino)-7-oxopyrido[2,3-d]pyrimidin-6-yl]phenyl]urea Chemical compound O=C1N(C)C2=NC(NC)=NC=C2C=C1C(C=1)=CC=C(F)C=1NC(=O)NC1=CC(C(C)(C)C)=NN1C1=CC=CN=C1 ZJDVUISBPLZXRQ-UHFFFAOYSA-N 0.000 claims 1
JNWJDYAMEBDPGZ-UHFFFAOYSA-N 1-(5-tert-butyl-2-pyridin-3-ylpyrazol-3-yl)-3-[3-(1-oxo-2,3-dihydroisoindol-4-yl)phenyl]urea Chemical compound N1=C(C(C)(C)C)C=C(NC(=O)NC=2C=C(C=CC=2)C=2C=3CNC(=O)C=3C=CC=2)N1C1=CC=CN=C1 JNWJDYAMEBDPGZ-UHFFFAOYSA-N 0.000 claims 1
AVKMBXXMUSKXHV-UHFFFAOYSA-N 1-(5-tert-butyl-2-pyridin-3-ylpyrazol-3-yl)-3-[3-[2-(methylamino)-7-oxo-8-propan-2-ylpyrido[2,3-d]pyrimidin-6-yl]phenyl]urea Chemical compound O=C1N(C(C)C)C2=NC(NC)=NC=C2C=C1C(C=1)=CC=CC=1NC(=O)NC1=CC(C(C)(C)C)=NN1C1=CC=CN=C1 AVKMBXXMUSKXHV-UHFFFAOYSA-N 0.000 claims 1
BOCIUEQASCLBTQ-UHFFFAOYSA-N 1-(5-tert-butyl-2-pyridin-3-ylpyrazol-3-yl)-3-[3-[8-(1-hydroxy-2-methylpropan-2-yl)-2-(methylamino)-7-oxopyrido[2,3-d]pyrimidin-6-yl]phenyl]urea Chemical compound O=C1N(C(C)(C)CO)C2=NC(NC)=NC=C2C=C1C(C=1)=CC=CC=1NC(=O)NC1=CC(C(C)(C)C)=NN1C1=CC=CN=C1 BOCIUEQASCLBTQ-UHFFFAOYSA-N 0.000 claims 1
KRTCIOQICONJDI-UHFFFAOYSA-N 1-(5-tert-butyl-2-pyridin-3-ylpyrazol-3-yl)-3-[3-[8-cyclopentyl-2-(methylamino)-7-oxopyrido[2,3-d]pyrimidin-6-yl]phenyl]urea Chemical compound O=C1N(C2CCCC2)C2=NC(NC)=NC=C2C=C1C(C=1)=CC=CC=1NC(=O)NC1=CC(C(C)(C)C)=NN1C1=CC=CN=C1 KRTCIOQICONJDI-UHFFFAOYSA-N 0.000 claims 1
YGOBGXVAPZOALP-UHFFFAOYSA-N 1-(5-tert-butyl-2-quinazolin-6-ylpyrazol-3-yl)-3-[2-fluoro-4-(1-oxo-2,3-dihydroisoindol-4-yl)phenyl]urea Chemical compound N1=CN=CC2=CC(N3C(NC(=O)NC=4C(=CC(=CC=4)C=4C=5CNC(=O)C=5C=CC=4)F)=CC(=N3)C(C)(C)C)=CC=C21 YGOBGXVAPZOALP-UHFFFAOYSA-N 0.000 claims 1
CCFNFNBPKDIARP-UHFFFAOYSA-N 1-(5-tert-butyl-2-quinazolin-6-ylpyrazol-3-yl)-3-[2-fluoro-4-[2-(1-methylpyrazol-4-yl)pyridin-4-yl]oxyphenyl]urea Chemical compound C1=NN(C)C=C1C1=CC(OC=2C=C(F)C(NC(=O)NC=3N(N=C(C=3)C(C)(C)C)C=3C=C4C=NC=NC4=CC=3)=CC=2)=CC=N1 CCFNFNBPKDIARP-UHFFFAOYSA-N 0.000 claims 1
SVHPKQQMJHJSDJ-UHFFFAOYSA-N 1-(5-tert-butyl-2-quinazolin-6-ylpyrazol-3-yl)-3-[2-fluoro-4-[2-(1h-pyrazol-4-yl)pyridin-4-yl]oxyphenyl]urea Chemical compound C=1C=C2N=CN=CC2=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)NC(C(=C1)F)=CC=C1OC(C=1)=CC=NC=1C=1C=NNC=1 SVHPKQQMJHJSDJ-UHFFFAOYSA-N 0.000 claims 1
OYJWHNHUTVNVFL-UHFFFAOYSA-N 1-(5-tert-butyl-2-quinazolin-6-ylpyrazol-3-yl)-3-[2-fluoro-4-[2-(methanesulfonamido)pyridin-4-yl]oxyphenyl]urea Chemical compound C=1C=C2N=CN=CC2=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)NC(C(=C1)F)=CC=C1OC1=CC=NC(NS(C)(=O)=O)=C1 OYJWHNHUTVNVFL-UHFFFAOYSA-N 0.000 claims 1
CALWIEDNTZNQGH-UHFFFAOYSA-N 1-(5-tert-butyl-2-quinazolin-6-ylpyrazol-3-yl)-3-[2-fluoro-4-[2-(propan-2-ylamino)pyridin-4-yl]oxyphenyl]urea Chemical compound C1=NC(NC(C)C)=CC(OC=2C=C(F)C(NC(=O)NC=3N(N=C(C=3)C(C)(C)C)C=3C=C4C=NC=NC4=CC=3)=CC=2)=C1 CALWIEDNTZNQGH-UHFFFAOYSA-N 0.000 claims 1
OCXSUYZJVXVYSC-UHFFFAOYSA-N 1-(5-tert-butyl-2-quinazolin-6-ylpyrazol-3-yl)-3-[2-fluoro-5-(1-oxo-2,3-dihydroisoindol-4-yl)phenyl]urea Chemical compound N1=CN=CC2=CC(N3C(NC(=O)NC=4C(=CC=C(C=4)C=4C=5CNC(=O)C=5C=CC=4)F)=CC(=N3)C(C)(C)C)=CC=C21 OCXSUYZJVXVYSC-UHFFFAOYSA-N 0.000 claims 1
AINAQNMWEWGCNX-UHFFFAOYSA-N 1-(5-tert-butyl-2-quinazolin-6-ylpyrazol-3-yl)-3-[3-(1-oxo-2,3-dihydroisoindol-4-yl)phenyl]urea Chemical compound N1=CN=CC2=CC(N3C(NC(=O)NC=4C=C(C=CC=4)C=4C=5CNC(=O)C=5C=CC=4)=CC(=N3)C(C)(C)C)=CC=C21 AINAQNMWEWGCNX-UHFFFAOYSA-N 0.000 claims 1
BNFBVELGGFGGIY-UHFFFAOYSA-N 1-(5-tert-butyl-2-quinazolin-6-ylpyrazol-3-yl)-3-[4-[2-(1h-pyrazol-4-yl)pyridin-4-yl]oxyphenyl]urea Chemical compound C=1C=C2N=CN=CC2=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC(C=1)=CC=NC=1C=1C=NNC=1 BNFBVELGGFGGIY-UHFFFAOYSA-N 0.000 claims 1
VJPBWOWKKLKNPE-UHFFFAOYSA-N 1-(5-tert-butyl-2-quinazolin-6-ylpyrazol-3-yl)-3-[4-[2-(methanesulfonamido)pyridin-4-yl]oxyphenyl]urea Chemical compound C=1C=C2N=CN=CC2=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC1=CC=NC(NS(C)(=O)=O)=C1 VJPBWOWKKLKNPE-UHFFFAOYSA-N 0.000 claims 1
JLCCGTBKCZMZDM-UHFFFAOYSA-N 1-(5-tert-butyl-2-quinolin-6-ylpyrazol-3-yl)-3-[2-fluoro-4-[2-(1h-pyrazol-4-yl)pyridin-4-yl]oxyphenyl]urea Chemical compound C=1C=C2N=CC=CC2=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)NC(C(=C1)F)=CC=C1OC(C=1)=CC=NC=1C=1C=NNC=1 JLCCGTBKCZMZDM-UHFFFAOYSA-N 0.000 claims 1
YPHFSMWXRBSMML-UHFFFAOYSA-N 1-(5-tert-butyl-2-quinolin-6-ylpyrazol-3-yl)-3-[2-fluoro-4-[2-(propan-2-ylamino)pyridin-4-yl]oxyphenyl]urea Chemical compound C1=NC(NC(C)C)=CC(OC=2C=C(F)C(NC(=O)NC=3N(N=C(C=3)C(C)(C)C)C=3C=C4C=CC=NC4=CC=3)=CC=2)=C1 YPHFSMWXRBSMML-UHFFFAOYSA-N 0.000 claims 1
MXOZMYIWGWYSCX-UHFFFAOYSA-N 1-(5-tert-butyl-2-quinolin-6-ylpyrazol-3-yl)-3-[4-[2-(1-methylpyrazol-4-yl)pyridin-4-yl]oxyphenyl]urea Chemical compound C1=NN(C)C=C1C1=CC(OC=2C=CC(NC(=O)NC=3N(N=C(C=3)C(C)(C)C)C=3C=C4C=CC=NC4=CC=3)=CC=2)=CC=N1 MXOZMYIWGWYSCX-UHFFFAOYSA-N 0.000 claims 1
LOTZKDFVDRBARK-UHFFFAOYSA-N 1-(5-tert-butyl-2-quinolin-6-ylpyrazol-3-yl)-3-[4-[2-(1h-pyrazol-4-yl)pyridin-4-yl]oxyphenyl]urea Chemical compound C=1C=C2N=CC=CC2=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC(C=1)=CC=NC=1C=1C=NNC=1 LOTZKDFVDRBARK-UHFFFAOYSA-N 0.000 claims 1
UKIXEDDYYJHYOA-UHFFFAOYSA-N 1-(5-tert-butyl-2-quinolin-6-ylpyrazol-3-yl)-3-[4-methyl-3-[8-methyl-2-(methylamino)-7-oxopyrido[2,3-d]pyrimidin-6-yl]phenyl]urea Chemical compound N1=CC=CC2=CC(N3N=C(C=C3NC(=O)NC=3C=C(C(=CC=3)C)C3=CC4=CN=C(N=C4N(C)C3=O)NC)C(C)(C)C)=CC=C21 UKIXEDDYYJHYOA-UHFFFAOYSA-N 0.000 claims 1
MCIBJIRAGVQRJK-UHFFFAOYSA-N 1-[1-tert-butyl-3-(1,2,3,4-tetrahydroisoquinolin-6-yl)pyrazol-4-yl]-3-(2,3-dichlorophenyl)urea Chemical compound C=1C=C2CNCCC2=CC=1C1=NN(C(C)(C)C)C=C1NC(=O)NC1=CC=CC(Cl)=C1Cl MCIBJIRAGVQRJK-UHFFFAOYSA-N 0.000 claims 1
FSODBRSQXPINJB-UHFFFAOYSA-N 1-[1-tert-butyl-3-(1,2,3,4-tetrahydroisoquinolin-6-yl)pyrazol-4-yl]-3-[2-fluoro-4-[2-(1-methylpyrazol-4-yl)pyridin-4-yl]oxyphenyl]urea Chemical compound C1=NN(C)C=C1C1=CC(OC=2C=C(F)C(NC(=O)NC=3C(=NN(C=3)C(C)(C)C)C=3C=C4CCNCC4=CC=3)=CC=2)=CC=N1 FSODBRSQXPINJB-UHFFFAOYSA-N 0.000 claims 1
WESYRWBCHCREHY-UHFFFAOYSA-N 1-[1-tert-butyl-3-(1,2,3,4-tetrahydroisoquinolin-6-yl)pyrazol-4-yl]-3-[2-fluoro-4-[2-(1h-pyrazol-4-yl)pyridin-4-yl]oxyphenyl]urea Chemical compound C=1C=C2CNCCC2=CC=1C1=NN(C(C)(C)C)C=C1NC(=O)NC(C(=C1)F)=CC=C1OC(C=1)=CC=NC=1C=1C=NNC=1 WESYRWBCHCREHY-UHFFFAOYSA-N 0.000 claims 1
QVZMNEQXBONNLX-UHFFFAOYSA-N 1-[1-tert-butyl-3-(1,2,3,4-tetrahydroisoquinolin-6-yl)pyrazol-4-yl]-3-[4-[2-(1-methylpyrazol-4-yl)pyridin-4-yl]oxyphenyl]urea Chemical compound C1=NN(C)C=C1C1=CC(OC=2C=CC(NC(=O)NC=3C(=NN(C=3)C(C)(C)C)C=3C=C4CCNCC4=CC=3)=CC=2)=CC=N1 QVZMNEQXBONNLX-UHFFFAOYSA-N 0.000 claims 1
ZBLCHKSUTQDHOX-UHFFFAOYSA-N 1-[1-tert-butyl-3-(1,2,3,4-tetrahydroisoquinolin-6-yl)pyrazol-4-yl]-3-[4-[2-(1h-pyrazol-4-yl)pyridin-4-yl]oxyphenyl]urea Chemical compound C=1C=C2CNCCC2=CC=1C1=NN(C(C)(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC(C=1)=CC=NC=1C=1C=NNC=1 ZBLCHKSUTQDHOX-UHFFFAOYSA-N 0.000 claims 1
HBMHHBKNPCYXEO-UHFFFAOYSA-N 1-[1-tert-butyl-3-(1,2,3,4-tetrahydroisoquinolin-6-yl)pyrazol-4-yl]-3-[4-[2-(methanesulfonamido)pyridin-4-yl]oxyphenyl]urea Chemical compound C=1C=C2CNCCC2=CC=1C1=NN(C(C)(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC1=CC=NC(NS(C)(=O)=O)=C1 HBMHHBKNPCYXEO-UHFFFAOYSA-N 0.000 claims 1
FHFAEOFTIHDQFL-UHFFFAOYSA-N 1-[1-tert-butyl-3-(1,2,3,4-tetrahydroisoquinolin-7-yl)pyrazol-4-yl]-3-[4-(1-oxo-2,3-dihydroisoindol-4-yl)phenyl]urea Chemical compound C1CNCC2=CC(C=3C(NC(=O)NC=4C=CC(=CC=4)C=4C=5CNC(=O)C=5C=CC=4)=CN(N=3)C(C)(C)C)=CC=C21 FHFAEOFTIHDQFL-UHFFFAOYSA-N 0.000 claims 1
RVSMSKDZWWOYNZ-UHFFFAOYSA-N 1-[1-tert-butyl-3-(1,3-thiazol-5-yl)pyrazol-4-yl]-3-[3-[2-(methylamino)-7-oxo-8-propan-2-ylpyrido[2,3-d]pyrimidin-6-yl]phenyl]urea Chemical compound O=C1N(C(C)C)C2=NC(NC)=NC=C2C=C1C(C=1)=CC=CC=1NC(=O)NC1=CN(C(C)(C)C)N=C1C1=CN=CS1 RVSMSKDZWWOYNZ-UHFFFAOYSA-N 0.000 claims 1
BCRVTHUZWOITFG-UHFFFAOYSA-N 1-[1-tert-butyl-3-(1h-indazol-5-yl)pyrazol-4-yl]-3-(2,3-dichlorophenyl)urea Chemical compound C=1C=C2NN=CC2=CC=1C1=NN(C(C)(C)C)C=C1NC(=O)NC1=CC=CC(Cl)=C1Cl BCRVTHUZWOITFG-UHFFFAOYSA-N 0.000 claims 1
VKXZROKDWJYREL-UHFFFAOYSA-N 1-[1-tert-butyl-3-(1h-indazol-5-yl)pyrazol-4-yl]-3-[2-fluoro-4-[2-(1h-pyrazol-4-yl)pyridin-4-yl]oxyphenyl]urea Chemical compound C=1C=C2NN=CC2=CC=1C1=NN(C(C)(C)C)C=C1NC(=O)NC(C(=C1)F)=CC=C1OC(C=1)=CC=NC=1C=1C=NNC=1 VKXZROKDWJYREL-UHFFFAOYSA-N 0.000 claims 1
SLPYSUJPSHSFEJ-UHFFFAOYSA-N 1-[1-tert-butyl-3-(1h-indazol-5-yl)pyrazol-4-yl]-3-[4-(1-oxo-2,3-dihydroisoindol-4-yl)phenyl]urea Chemical compound C1=C2NN=CC2=CC(C=2C(NC(=O)NC=3C=CC(=CC=3)C=3C=4CNC(=O)C=4C=CC=3)=CN(N=2)C(C)(C)C)=C1 SLPYSUJPSHSFEJ-UHFFFAOYSA-N 0.000 claims 1
NLTBLIJVRHDJHG-UHFFFAOYSA-N 1-[1-tert-butyl-3-(1h-indazol-5-yl)pyrazol-4-yl]-3-[4-[2-(1h-pyrazol-4-yl)pyridin-4-yl]oxyphenyl]urea Chemical compound C=1C=C2NN=CC2=CC=1C1=NN(C(C)(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC(C=1)=CC=NC=1C=1C=NNC=1 NLTBLIJVRHDJHG-UHFFFAOYSA-N 0.000 claims 1
JWDKXOXRRAVDFH-UHFFFAOYSA-N 1-[1-tert-butyl-3-(2-methyl-3,4-dihydro-1h-isoquinolin-6-yl)pyrazol-4-yl]-3-(2,3-dichlorophenyl)urea Chemical compound C=1C=C2CN(C)CCC2=CC=1C1=NN(C(C)(C)C)C=C1NC(=O)NC1=CC=CC(Cl)=C1Cl JWDKXOXRRAVDFH-UHFFFAOYSA-N 0.000 claims 1
ZUPGAGLHLLLNIH-UHFFFAOYSA-N 1-[1-tert-butyl-3-(2-methyl-3,4-dihydro-1h-isoquinolin-6-yl)pyrazol-4-yl]-3-[2-fluoro-4-(1-oxo-2,3-dihydroisoindol-4-yl)phenyl]urea Chemical compound C=1C=C2CN(C)CCC2=CC=1C1=NN(C(C)(C)C)C=C1NC(=O)NC(C(=C1)F)=CC=C1C1=CC=CC2=C1CNC2=O ZUPGAGLHLLLNIH-UHFFFAOYSA-N 0.000 claims 1
DXKHKLDCHRFSRP-UHFFFAOYSA-N 1-[1-tert-butyl-3-(2-methyl-3,4-dihydro-1h-isoquinolin-6-yl)pyrazol-4-yl]-3-[2-fluoro-4-[2-(1h-pyrazol-4-yl)pyridin-4-yl]oxyphenyl]urea Chemical compound C=1C=C2CN(C)CCC2=CC=1C1=NN(C(C)(C)C)C=C1NC(=O)NC(C(=C1)F)=CC=C1OC(C=1)=CC=NC=1C=1C=NNC=1 DXKHKLDCHRFSRP-UHFFFAOYSA-N 0.000 claims 1
ZTCZMEFBTLTSJC-UHFFFAOYSA-N 1-[1-tert-butyl-3-(2-methyl-3,4-dihydro-1h-isoquinolin-6-yl)pyrazol-4-yl]-3-[4-[2-(1-methylpyrazol-4-yl)pyridin-4-yl]oxyphenyl]urea Chemical compound C=1C=C2CN(C)CCC2=CC=1C1=NN(C(C)(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC(C=1)=CC=NC=1C=1C=NN(C)C=1 ZTCZMEFBTLTSJC-UHFFFAOYSA-N 0.000 claims 1
XDPKXLXBKMEGGH-UHFFFAOYSA-N 1-[1-tert-butyl-3-(2-methyl-3,4-dihydro-1h-isoquinolin-6-yl)pyrazol-4-yl]-3-[4-[2-(1h-pyrazol-4-yl)pyridin-4-yl]oxyphenyl]urea Chemical compound C=1C=C2CN(C)CCC2=CC=1C1=NN(C(C)(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC(C=1)=CC=NC=1C=1C=NNC=1 XDPKXLXBKMEGGH-UHFFFAOYSA-N 0.000 claims 1
VXAGOLXWFHJHRJ-UHFFFAOYSA-N 1-[1-tert-butyl-3-(2-methyl-3,4-dihydro-1h-isoquinolin-7-yl)pyrazol-4-yl]-3-[2-fluoro-4-[2-(1-methylpyrazol-4-yl)pyridin-4-yl]oxyphenyl]urea Chemical compound C1=C2CN(C)CCC2=CC=C1C1=NN(C(C)(C)C)C=C1NC(=O)NC(C(=C1)F)=CC=C1OC(C=1)=CC=NC=1C=1C=NN(C)C=1 VXAGOLXWFHJHRJ-UHFFFAOYSA-N 0.000 claims 1
OUUKPNMZXNFALG-UHFFFAOYSA-N 1-[1-tert-butyl-3-(2-methyl-3,4-dihydro-1h-isoquinolin-7-yl)pyrazol-4-yl]-3-[2-fluoro-4-[2-(methanesulfonamido)pyridin-4-yl]oxyphenyl]urea Chemical compound C1=C2CN(C)CCC2=CC=C1C1=NN(C(C)(C)C)C=C1NC(=O)NC(C(=C1)F)=CC=C1OC1=CC=NC(NS(C)(=O)=O)=C1 OUUKPNMZXNFALG-UHFFFAOYSA-N 0.000 claims 1
IRZXFATYFQSKCT-UHFFFAOYSA-N 1-[1-tert-butyl-3-(2-methyl-3,4-dihydro-1h-isoquinolin-7-yl)pyrazol-4-yl]-3-[4-(1-oxo-2,3-dihydroisoindol-4-yl)phenyl]urea Chemical compound C1=C2CN(C)CCC2=CC=C1C1=NN(C(C)(C)C)C=C1NC(=O)NC(C=C1)=CC=C1C1=CC=CC2=C1CNC2=O IRZXFATYFQSKCT-UHFFFAOYSA-N 0.000 claims 1
OIXLQCXLLVHYPB-UHFFFAOYSA-N 1-[1-tert-butyl-3-(2-methyl-3,4-dihydro-1h-isoquinolin-7-yl)pyrazol-4-yl]-3-[4-[2-(1-methylpyrazol-4-yl)pyridin-4-yl]oxyphenyl]urea Chemical compound C1=C2CN(C)CCC2=CC=C1C1=NN(C(C)(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC(C=1)=CC=NC=1C=1C=NN(C)C=1 OIXLQCXLLVHYPB-UHFFFAOYSA-N 0.000 claims 1
SXZFHFMBAKXWTJ-UHFFFAOYSA-N 1-[1-tert-butyl-3-(2-methyl-3,4-dihydro-1h-isoquinolin-7-yl)pyrazol-4-yl]-3-[4-[2-(methanesulfonamido)pyridin-4-yl]oxyphenyl]urea Chemical compound C1=C2CN(C)CCC2=CC=C1C1=NN(C(C)(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC1=CC=NC(NS(C)(=O)=O)=C1 SXZFHFMBAKXWTJ-UHFFFAOYSA-N 0.000 claims 1
RXKAMTIYQUNRGM-UHFFFAOYSA-N 1-[1-tert-butyl-3-(3-cyanophenyl)pyrazol-4-yl]-3-[2-fluoro-4-[2-(1h-pyrazol-4-yl)pyridin-4-yl]oxyphenyl]urea Chemical compound C=1C=CC(C#N)=CC=1C1=NN(C(C)(C)C)C=C1NC(=O)NC(C(=C1)F)=CC=C1OC(C=1)=CC=NC=1C=1C=NNC=1 RXKAMTIYQUNRGM-UHFFFAOYSA-N 0.000 claims 1
OWOYSNWLCDHABS-UHFFFAOYSA-N 1-[1-tert-butyl-3-(3-cyanophenyl)pyrazol-4-yl]-3-[2-fluoro-5-[2-(methylamino)-7-oxo-8-propan-2-ylpyrido[2,3-d]pyrimidin-6-yl]phenyl]urea Chemical compound O=C1N(C(C)C)C2=NC(NC)=NC=C2C=C1C(C=1)=CC=C(F)C=1NC(=O)NC1=CN(C(C)(C)C)N=C1C1=CC=CC(C#N)=C1 OWOYSNWLCDHABS-UHFFFAOYSA-N 0.000 claims 1
YCLUKIYURXRTMW-UHFFFAOYSA-N 1-[1-tert-butyl-3-(3-cyanophenyl)pyrazol-4-yl]-3-[2-fluoro-5-[8-methyl-2-(methylamino)-7-oxopyrido[2,3-d]pyrimidin-6-yl]phenyl]urea Chemical compound O=C1N(C)C2=NC(NC)=NC=C2C=C1C(C=1)=CC=C(F)C=1NC(=O)NC1=CN(C(C)(C)C)N=C1C1=CC=CC(C#N)=C1 YCLUKIYURXRTMW-UHFFFAOYSA-N 0.000 claims 1
YMMZUWQZTVOLIG-UHFFFAOYSA-N 1-[1-tert-butyl-3-(3-cyanophenyl)pyrazol-4-yl]-3-[3-[2-(methylamino)-7-oxo-8-propan-2-ylpyrido[2,3-d]pyrimidin-6-yl]phenyl]urea Chemical compound O=C1N(C(C)C)C2=NC(NC)=NC=C2C=C1C(C=1)=CC=CC=1NC(=O)NC1=CN(C(C)(C)C)N=C1C1=CC=CC(C#N)=C1 YMMZUWQZTVOLIG-UHFFFAOYSA-N 0.000 claims 1
AUTPEWXBSRISOQ-UHFFFAOYSA-N 1-[1-tert-butyl-3-(3-cyanophenyl)pyrazol-4-yl]-3-[3-[8-methyl-2-(methylamino)-7-oxopyrido[2,3-d]pyrimidin-6-yl]phenyl]urea Chemical compound O=C1N(C)C2=NC(NC)=NC=C2C=C1C(C=1)=CC=CC=1NC(=O)NC1=CN(C(C)(C)C)N=C1C1=CC=CC(C#N)=C1 AUTPEWXBSRISOQ-UHFFFAOYSA-N 0.000 claims 1
CXFLTESMWLQSEK-UHFFFAOYSA-N 1-[1-tert-butyl-3-(3-cyanophenyl)pyrazol-4-yl]-3-[4-(1-oxo-2,3-dihydroisoindol-4-yl)phenyl]urea Chemical compound N=1N(C(C)(C)C)C=C(NC(=O)NC=2C=CC(=CC=2)C=2C=3CNC(=O)C=3C=CC=2)C=1C1=CC=CC(C#N)=C1 CXFLTESMWLQSEK-UHFFFAOYSA-N 0.000 claims 1
BIDVRDRGUYMXIT-UHFFFAOYSA-N 1-[1-tert-butyl-3-(3-cyanophenyl)pyrazol-4-yl]-3-[4-[2-(1h-pyrazol-4-yl)pyridin-4-yl]oxyphenyl]urea Chemical compound C=1C=CC(C#N)=CC=1C1=NN(C(C)(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC(C=1)=CC=NC=1C=1C=NNC=1 BIDVRDRGUYMXIT-UHFFFAOYSA-N 0.000 claims 1
ZCBWFGLRNGSFFI-UHFFFAOYSA-N 1-[1-tert-butyl-3-(3-cyanophenyl)pyrazol-4-yl]-3-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]urea Chemical compound C1=C(NC=2N=C(C=CN=2)C=2C=NC=CC=2)C(C)=CC=C1NC(=O)NC1=CN(C(C)(C)C)N=C1C1=CC=CC(C#N)=C1 ZCBWFGLRNGSFFI-UHFFFAOYSA-N 0.000 claims 1
XOJTURVQPAVVNL-UHFFFAOYSA-N 1-[1-tert-butyl-3-(3-fluorophenyl)pyrazol-4-yl]-3-[3-[2-(methylamino)-7-oxo-8-propan-2-ylpyrido[2,3-d]pyrimidin-6-yl]phenyl]urea Chemical compound O=C1N(C(C)C)C2=NC(NC)=NC=C2C=C1C(C=1)=CC=CC=1NC(=O)NC1=CN(C(C)(C)C)N=C1C1=CC=CC(F)=C1 XOJTURVQPAVVNL-UHFFFAOYSA-N 0.000 claims 1
JMBWIRQGENSNAU-UHFFFAOYSA-N 1-[1-tert-butyl-3-(3-fluorophenyl)pyrazol-4-yl]-3-[3-[8-methyl-2-(methylamino)-7-oxopyrido[2,3-d]pyrimidin-6-yl]phenyl]urea Chemical compound O=C1N(C)C2=NC(NC)=NC=C2C=C1C(C=1)=CC=CC=1NC(=O)NC1=CN(C(C)(C)C)N=C1C1=CC=CC(F)=C1 JMBWIRQGENSNAU-UHFFFAOYSA-N 0.000 claims 1
MKXBBYKTXPQNKU-UHFFFAOYSA-N 1-[1-tert-butyl-3-(4-cyanophenyl)pyrazol-4-yl]-3-[2-fluoro-4-[2-(1-methylpyrazol-4-yl)pyridin-4-yl]oxyphenyl]urea Chemical compound C1=NN(C)C=C1C1=CC(OC=2C=C(F)C(NC(=O)NC=3C(=NN(C=3)C(C)(C)C)C=3C=CC(=CC=3)C#N)=CC=2)=CC=N1 MKXBBYKTXPQNKU-UHFFFAOYSA-N 0.000 claims 1
VHHNYFSQLAZHAR-UHFFFAOYSA-N 1-[1-tert-butyl-3-(4-cyanophenyl)pyrazol-4-yl]-3-[2-fluoro-4-[2-(1h-pyrazol-4-yl)pyridin-4-yl]oxyphenyl]urea Chemical compound C=1C=C(C#N)C=CC=1C1=NN(C(C)(C)C)C=C1NC(=O)NC(C(=C1)F)=CC=C1OC(C=1)=CC=NC=1C=1C=NNC=1 VHHNYFSQLAZHAR-UHFFFAOYSA-N 0.000 claims 1
UWTWRSYCVAZLGH-UHFFFAOYSA-N 1-[1-tert-butyl-3-(4-cyanophenyl)pyrazol-4-yl]-3-[2-fluoro-5-[2-(methylamino)-7-oxo-8-propan-2-ylpyrido[2,3-d]pyrimidin-6-yl]phenyl]urea Chemical compound O=C1N(C(C)C)C2=NC(NC)=NC=C2C=C1C(C=1)=CC=C(F)C=1NC(=O)NC1=CN(C(C)(C)C)N=C1C1=CC=C(C#N)C=C1 UWTWRSYCVAZLGH-UHFFFAOYSA-N 0.000 claims 1
AAPGQCDNYDJJJH-UHFFFAOYSA-N 1-[1-tert-butyl-3-(4-cyanophenyl)pyrazol-4-yl]-3-[3-[2-(methylamino)-7-oxo-8-propan-2-ylpyrido[2,3-d]pyrimidin-6-yl]phenyl]urea Chemical compound O=C1N(C(C)C)C2=NC(NC)=NC=C2C=C1C(C=1)=CC=CC=1NC(=O)NC1=CN(C(C)(C)C)N=C1C1=CC=C(C#N)C=C1 AAPGQCDNYDJJJH-UHFFFAOYSA-N 0.000 claims 1
FKFMWMOJPYSQMP-UHFFFAOYSA-N 1-[1-tert-butyl-3-(4-cyanophenyl)pyrazol-4-yl]-3-[3-[8-methyl-2-(methylamino)-7-oxopyrido[2,3-d]pyrimidin-6-yl]phenyl]urea Chemical compound O=C1N(C)C2=NC(NC)=NC=C2C=C1C(C=1)=CC=CC=1NC(=O)NC1=CN(C(C)(C)C)N=C1C1=CC=C(C#N)C=C1 FKFMWMOJPYSQMP-UHFFFAOYSA-N 0.000 claims 1
RWMFKGHUJPGVTP-UHFFFAOYSA-N 1-[1-tert-butyl-3-(4-fluorophenyl)pyrazol-4-yl]-3-[2-fluoro-4-(1-oxo-2,3-dihydroisoindol-4-yl)phenyl]urea Chemical compound N=1N(C(C)(C)C)C=C(NC(=O)NC=2C(=CC(=CC=2)C=2C=3CNC(=O)C=3C=CC=2)F)C=1C1=CC=C(F)C=C1 RWMFKGHUJPGVTP-UHFFFAOYSA-N 0.000 claims 1
DTZGGQCFFFHIHI-UHFFFAOYSA-N 1-[1-tert-butyl-3-(4-fluorophenyl)pyrazol-4-yl]-3-[2-fluoro-4-[2-(1-methylpyrazol-4-yl)pyridin-4-yl]oxyphenyl]urea Chemical compound C1=NN(C)C=C1C1=CC(OC=2C=C(F)C(NC(=O)NC=3C(=NN(C=3)C(C)(C)C)C=3C=CC(F)=CC=3)=CC=2)=CC=N1 DTZGGQCFFFHIHI-UHFFFAOYSA-N 0.000 claims 1
DVHUXPNPFHMGIE-UHFFFAOYSA-N 1-[1-tert-butyl-3-(4-fluorophenyl)pyrazol-4-yl]-3-[2-fluoro-5-[8-methyl-2-(methylamino)-7-oxopyrido[2,3-d]pyrimidin-6-yl]phenyl]urea Chemical compound O=C1N(C)C2=NC(NC)=NC=C2C=C1C(C=1)=CC=C(F)C=1NC(=O)NC1=CN(C(C)(C)C)N=C1C1=CC=C(F)C=C1 DVHUXPNPFHMGIE-UHFFFAOYSA-N 0.000 claims 1
DAADIUHMZAADTG-UHFFFAOYSA-N 1-[1-tert-butyl-3-(4-fluorophenyl)pyrazol-4-yl]-3-[3-[2-(methylamino)-7-oxo-8-propan-2-ylpyrido[2,3-d]pyrimidin-6-yl]phenyl]urea Chemical compound O=C1N(C(C)C)C2=NC(NC)=NC=C2C=C1C(C=1)=CC=CC=1NC(=O)NC1=CN(C(C)(C)C)N=C1C1=CC=C(F)C=C1 DAADIUHMZAADTG-UHFFFAOYSA-N 0.000 claims 1
QLMSUYKLGWQGHY-UHFFFAOYSA-N 1-[1-tert-butyl-3-(4-fluorophenyl)pyrazol-4-yl]-3-[3-[8-methyl-2-(methylamino)-7-oxopyrido[2,3-d]pyrimidin-6-yl]phenyl]urea Chemical compound O=C1N(C)C2=NC(NC)=NC=C2C=C1C(C=1)=CC=CC=1NC(=O)NC1=CN(C(C)(C)C)N=C1C1=CC=C(F)C=C1 QLMSUYKLGWQGHY-UHFFFAOYSA-N 0.000 claims 1
JNMCZWGHBACZSY-UHFFFAOYSA-N 1-[1-tert-butyl-3-(4-fluorophenyl)pyrazol-4-yl]-3-[4-[2-(1-methylpyrazol-4-yl)pyridin-4-yl]oxyphenyl]urea Chemical compound C1=NN(C)C=C1C1=CC(OC=2C=CC(NC(=O)NC=3C(=NN(C=3)C(C)(C)C)C=3C=CC(F)=CC=3)=CC=2)=CC=N1 JNMCZWGHBACZSY-UHFFFAOYSA-N 0.000 claims 1
GUCPQCDJGQNGOV-UHFFFAOYSA-N 1-[1-tert-butyl-3-(4-fluorophenyl)pyrazol-4-yl]-3-[4-[2-(1h-pyrazol-4-yl)pyridin-4-yl]oxyphenyl]urea Chemical compound C=1C=C(F)C=CC=1C1=NN(C(C)(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC(C=1)=CC=NC=1C=1C=NNC=1 GUCPQCDJGQNGOV-UHFFFAOYSA-N 0.000 claims 1
MCQRZOWSBUFHAD-UHFFFAOYSA-N 1-[1-tert-butyl-3-(6-cyanopyridin-3-yl)pyrazol-4-yl]-3-[2-fluoro-4-[2-(1-methylpyrazol-4-yl)pyridin-4-yl]oxyphenyl]urea Chemical compound C1=NN(C)C=C1C1=CC(OC=2C=C(F)C(NC(=O)NC=3C(=NN(C=3)C(C)(C)C)C=3C=NC(=CC=3)C#N)=CC=2)=CC=N1 MCQRZOWSBUFHAD-UHFFFAOYSA-N 0.000 claims 1
CYLKIQFHMKLKHZ-UHFFFAOYSA-N 1-[1-tert-butyl-3-(6-cyanopyridin-3-yl)pyrazol-4-yl]-3-[2-fluoro-4-[2-(1h-pyrazol-4-yl)pyridin-4-yl]oxyphenyl]urea Chemical compound C=1C=C(C#N)N=CC=1C1=NN(C(C)(C)C)C=C1NC(=O)NC(C(=C1)F)=CC=C1OC(C=1)=CC=NC=1C=1C=NNC=1 CYLKIQFHMKLKHZ-UHFFFAOYSA-N 0.000 claims 1
ZCSYDNRMAWSXDF-UHFFFAOYSA-N 1-[1-tert-butyl-3-(6-cyanopyridin-3-yl)pyrazol-4-yl]-3-[2-fluoro-5-[2-(methylamino)-7-oxo-8-propan-2-ylpyrido[2,3-d]pyrimidin-6-yl]phenyl]urea Chemical compound O=C1N(C(C)C)C2=NC(NC)=NC=C2C=C1C(C=1)=CC=C(F)C=1NC(=O)NC1=CN(C(C)(C)C)N=C1C1=CC=C(C#N)N=C1 ZCSYDNRMAWSXDF-UHFFFAOYSA-N 0.000 claims 1
GCJGBUCOUFUQFJ-UHFFFAOYSA-N 1-[1-tert-butyl-3-(6-cyanopyridin-3-yl)pyrazol-4-yl]-3-[2-fluoro-5-[8-methyl-2-(methylamino)-7-oxopyrido[2,3-d]pyrimidin-6-yl]phenyl]urea Chemical compound O=C1N(C)C2=NC(NC)=NC=C2C=C1C(C=1)=CC=C(F)C=1NC(=O)NC1=CN(C(C)(C)C)N=C1C1=CC=C(C#N)N=C1 GCJGBUCOUFUQFJ-UHFFFAOYSA-N 0.000 claims 1
ANIAWPRHMKXSQB-UHFFFAOYSA-N 1-[1-tert-butyl-3-(6-cyanopyridin-3-yl)pyrazol-4-yl]-3-[3-[2-(methylamino)-7-oxo-8-propan-2-ylpyrido[2,3-d]pyrimidin-6-yl]phenyl]urea Chemical compound O=C1N(C(C)C)C2=NC(NC)=NC=C2C=C1C(C=1)=CC=CC=1NC(=O)NC1=CN(C(C)(C)C)N=C1C1=CC=C(C#N)N=C1 ANIAWPRHMKXSQB-UHFFFAOYSA-N 0.000 claims 1
BLRRNVUBURYXIG-UHFFFAOYSA-N 1-[1-tert-butyl-3-(6-cyanopyridin-3-yl)pyrazol-4-yl]-3-[3-[8-methyl-2-(methylamino)-7-oxopyrido[2,3-d]pyrimidin-6-yl]phenyl]urea Chemical compound O=C1N(C)C2=NC(NC)=NC=C2C=C1C(C=1)=CC=CC=1NC(=O)NC1=CN(C(C)(C)C)N=C1C1=CC=C(C#N)N=C1 BLRRNVUBURYXIG-UHFFFAOYSA-N 0.000 claims 1
ACEZBBSDBDJGCH-UHFFFAOYSA-N 1-[1-tert-butyl-3-(6-cyanopyridin-3-yl)pyrazol-4-yl]-3-[4-[2-(1-methylpyrazol-4-yl)pyridin-4-yl]oxyphenyl]urea Chemical compound C1=NN(C)C=C1C1=CC(OC=2C=CC(NC(=O)NC=3C(=NN(C=3)C(C)(C)C)C=3C=NC(=CC=3)C#N)=CC=2)=CC=N1 ACEZBBSDBDJGCH-UHFFFAOYSA-N 0.000 claims 1
PGJDIYFCEKIORW-UHFFFAOYSA-N 1-[1-tert-butyl-3-(6-cyanopyridin-3-yl)pyrazol-4-yl]-3-[4-[2-(1h-pyrazol-4-yl)pyridin-4-yl]oxyphenyl]urea Chemical compound C=1C=C(C#N)N=CC=1C1=NN(C(C)(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC(C=1)=CC=NC=1C=1C=NNC=1 PGJDIYFCEKIORW-UHFFFAOYSA-N 0.000 claims 1
UOBWARZRLDGURW-UHFFFAOYSA-N 1-[2-(1,2-benzoxazol-5-yl)-5-propan-2-ylpyrazol-3-yl]-3-[2-fluoro-4-[2-(1h-pyrazol-4-yl)pyridin-4-yl]oxyphenyl]urea Chemical compound C=1C=C2ON=CC2=CC=1N1N=C(C(C)C)C=C1NC(=O)NC(C(=C1)F)=CC=C1OC(C=1)=CC=NC=1C=1C=NNC=1 UOBWARZRLDGURW-UHFFFAOYSA-N 0.000 claims 1
DRUXQOPGCMRHSM-UHFFFAOYSA-N 1-[2-(1,2-benzoxazol-5-yl)-5-propan-2-ylpyrazol-3-yl]-3-[2-fluoro-4-[2-(methanesulfonamido)pyridin-4-yl]oxyphenyl]urea Chemical compound C=1C=C2ON=CC2=CC=1N1N=C(C(C)C)C=C1NC(=O)NC(C(=C1)F)=CC=C1OC1=CC=NC(NS(C)(=O)=O)=C1 DRUXQOPGCMRHSM-UHFFFAOYSA-N 0.000 claims 1
HMJYCLGJENSXEK-UHFFFAOYSA-N 1-[2-(1,2-benzoxazol-5-yl)-5-propan-2-ylpyrazol-3-yl]-3-[4-[2-(propan-2-ylamino)pyridin-4-yl]oxyphenyl]urea Chemical compound C1=NC(NC(C)C)=CC(OC=2C=CC(NC(=O)NC=3N(N=C(C=3)C(C)C)C=3C=C4C=NOC4=CC=3)=CC=2)=C1 HMJYCLGJENSXEK-UHFFFAOYSA-N 0.000 claims 1
FJSWPNIAEUJFCT-UHFFFAOYSA-N 1-[2-(1,2-benzoxazol-5-yl)-5-tert-butylpyrazol-3-yl]-3-[2-fluoro-4-[2-(1h-pyrazol-4-yl)pyridin-4-yl]oxyphenyl]urea Chemical compound C=1C=C2ON=CC2=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)NC(C(=C1)F)=CC=C1OC(C=1)=CC=NC=1C=1C=NNC=1 FJSWPNIAEUJFCT-UHFFFAOYSA-N 0.000 claims 1
LHIWNBKXMPXZFN-UHFFFAOYSA-N 1-[2-(1,2-benzoxazol-5-yl)-5-tert-butylpyrazol-3-yl]-3-[2-fluoro-4-[2-(methanesulfonamido)pyridin-4-yl]oxyphenyl]urea Chemical compound C=1C=C2ON=CC2=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)NC(C(=C1)F)=CC=C1OC1=CC=NC(NS(C)(=O)=O)=C1 LHIWNBKXMPXZFN-UHFFFAOYSA-N 0.000 claims 1
KYRWPYLCXRRGKU-UHFFFAOYSA-N 1-[2-(1,2-benzoxazol-5-yl)-5-tert-butylpyrazol-3-yl]-3-[2-fluoro-5-(1-oxo-2,3-dihydroisoindol-4-yl)phenyl]urea Chemical compound C1=C2ON=CC2=CC(N2C(NC(=O)NC=3C(=CC=C(C=3)C=3C=4CNC(=O)C=4C=CC=3)F)=CC(=N2)C(C)(C)C)=C1 KYRWPYLCXRRGKU-UHFFFAOYSA-N 0.000 claims 1
NEBXSBUYADVQSH-UHFFFAOYSA-N 1-[2-(1,2-benzoxazol-5-yl)-5-tert-butylpyrazol-3-yl]-3-[2-fluoro-5-[8-methyl-2-(methylamino)-7-oxopyrido[2,3-d]pyrimidin-6-yl]phenyl]urea Chemical compound C1=C2ON=CC2=CC(N2N=C(C=C2NC(=O)NC=2C(F)=CC=C(C=2)C2=CC3=CN=C(N=C3N(C)C2=O)NC)C(C)(C)C)=C1 NEBXSBUYADVQSH-UHFFFAOYSA-N 0.000 claims 1
LWJUOLKUIAIJFI-UHFFFAOYSA-N 1-[2-(1,2-benzoxazol-5-yl)-5-tert-butylpyrazol-3-yl]-3-[3-(1-oxo-2,3-dihydroisoindol-4-yl)phenyl]urea Chemical compound C1=C2ON=CC2=CC(N2C(NC(=O)NC=3C=C(C=CC=3)C=3C=4CNC(=O)C=4C=CC=3)=CC(=N2)C(C)(C)C)=C1 LWJUOLKUIAIJFI-UHFFFAOYSA-N 0.000 claims 1
VSZWIMSVMMXZBN-UHFFFAOYSA-N 1-[2-(1,2-benzoxazol-5-yl)-5-tert-butylpyrazol-3-yl]-3-[4-(1-oxo-2,3-dihydroisoindol-4-yl)phenyl]urea Chemical compound C1=C2ON=CC2=CC(N2C(NC(=O)NC=3C=CC(=CC=3)C=3C=4CNC(=O)C=4C=CC=3)=CC(=N2)C(C)(C)C)=C1 VSZWIMSVMMXZBN-UHFFFAOYSA-N 0.000 claims 1
NRZUQHLNHOWFDF-UHFFFAOYSA-N 1-[2-(1,2-benzoxazol-5-yl)-5-tert-butylpyrazol-3-yl]-3-[4-[2-(propan-2-ylamino)pyridin-4-yl]oxyphenyl]urea Chemical compound C1=NC(NC(C)C)=CC(OC=2C=CC(NC(=O)NC=3N(N=C(C=3)C(C)(C)C)C=3C=C4C=NOC4=CC=3)=CC=2)=C1 NRZUQHLNHOWFDF-UHFFFAOYSA-N 0.000 claims 1
HHSBZIOVMOMGNE-UHFFFAOYSA-N 1-[2-(1,3-benzothiazol-5-yl)-5-propan-2-ylpyrazol-3-yl]-3-[2-fluoro-4-[2-(propan-2-ylamino)pyridin-4-yl]oxyphenyl]urea Chemical compound C1=NC(NC(C)C)=CC(OC=2C=C(F)C(NC(=O)NC=3N(N=C(C=3)C(C)C)C=3C=C4N=CSC4=CC=3)=CC=2)=C1 HHSBZIOVMOMGNE-UHFFFAOYSA-N 0.000 claims 1
HBXRGCINTDOSIU-UHFFFAOYSA-N 1-[2-(1,3-benzothiazol-5-yl)-5-propan-2-ylpyrazol-3-yl]-3-[4-[2-(methanesulfonamido)pyridin-4-yl]oxyphenyl]urea Chemical compound C=1C=C2SC=NC2=CC=1N1N=C(C(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC1=CC=NC(NS(C)(=O)=O)=C1 HBXRGCINTDOSIU-UHFFFAOYSA-N 0.000 claims 1
VAFXMAGBZZNGSN-UHFFFAOYSA-N 1-[2-(1,3-benzothiazol-5-yl)-5-propan-2-ylpyrazol-3-yl]-3-[4-[2-(propan-2-ylamino)pyridin-4-yl]oxyphenyl]urea Chemical compound C1=NC(NC(C)C)=CC(OC=2C=CC(NC(=O)NC=3N(N=C(C=3)C(C)C)C=3C=C4N=CSC4=CC=3)=CC=2)=C1 VAFXMAGBZZNGSN-UHFFFAOYSA-N 0.000 claims 1
RNLMHQMDLGEGIA-UHFFFAOYSA-N 1-[2-(1,3-benzothiazol-5-yl)-5-tert-butylpyrazol-3-yl]-3-(2,3-dichlorophenyl)urea Chemical compound C=1C=C2SC=NC2=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)NC1=CC=CC(Cl)=C1Cl RNLMHQMDLGEGIA-UHFFFAOYSA-N 0.000 claims 1
OTHHAQUHZUDCTP-UHFFFAOYSA-N 1-[2-(1,3-benzothiazol-5-yl)-5-tert-butylpyrazol-3-yl]-3-[2-fluoro-4-(1-oxo-2,3-dihydroisoindol-4-yl)phenyl]urea Chemical compound C1=C2SC=NC2=CC(N2C(NC(=O)NC=3C(=CC(=CC=3)C=3C=4CNC(=O)C=4C=CC=3)F)=CC(=N2)C(C)(C)C)=C1 OTHHAQUHZUDCTP-UHFFFAOYSA-N 0.000 claims 1
GSNJPOMBPBQTMH-UHFFFAOYSA-N 1-[2-(1,3-benzothiazol-5-yl)-5-tert-butylpyrazol-3-yl]-3-[2-fluoro-4-[2-(methanesulfonamido)pyridin-4-yl]oxyphenyl]urea Chemical compound C=1C=C2SC=NC2=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)NC(C(=C1)F)=CC=C1OC1=CC=NC(NS(C)(=O)=O)=C1 GSNJPOMBPBQTMH-UHFFFAOYSA-N 0.000 claims 1
WIXRZXPDCWXYRV-UHFFFAOYSA-N 1-[2-(1,3-benzothiazol-5-yl)-5-tert-butylpyrazol-3-yl]-3-[2-fluoro-5-[8-methyl-2-(methylamino)-7-oxopyrido[2,3-d]pyrimidin-6-yl]phenyl]urea Chemical compound C1=C2SC=NC2=CC(N2N=C(C=C2NC(=O)NC=2C(F)=CC=C(C=2)C2=CC3=CN=C(N=C3N(C)C2=O)NC)C(C)(C)C)=C1 WIXRZXPDCWXYRV-UHFFFAOYSA-N 0.000 claims 1
WGKOQUBQFNWCLZ-UHFFFAOYSA-N 1-[2-(1,3-benzothiazol-5-yl)-5-tert-butylpyrazol-3-yl]-3-[3-(1-oxo-2,3-dihydroisoindol-4-yl)phenyl]urea Chemical compound C1=C2SC=NC2=CC(N2C(NC(=O)NC=3C=C(C=CC=3)C=3C=4CNC(=O)C=4C=CC=3)=CC(=N2)C(C)(C)C)=C1 WGKOQUBQFNWCLZ-UHFFFAOYSA-N 0.000 claims 1
ZBUHHGUQWNHGMC-UHFFFAOYSA-N 1-[2-(1,3-benzothiazol-5-yl)-5-tert-butylpyrazol-3-yl]-3-[4-(1-oxo-2,3-dihydroisoindol-4-yl)phenyl]urea Chemical compound C1=C2SC=NC2=CC(N2C(NC(=O)NC=3C=CC(=CC=3)C=3C=4CNC(=O)C=4C=CC=3)=CC(=N2)C(C)(C)C)=C1 ZBUHHGUQWNHGMC-UHFFFAOYSA-N 0.000 claims 1
MXHPMGJFJIDBMB-UHFFFAOYSA-N 1-[2-(1,3-benzothiazol-5-yl)-5-tert-butylpyrazol-3-yl]-3-[4-[2-(propan-2-ylamino)pyridin-4-yl]oxyphenyl]urea Chemical compound C1=NC(NC(C)C)=CC(OC=2C=CC(NC(=O)NC=3N(N=C(C=3)C(C)(C)C)C=3C=C4N=CSC4=CC=3)=CC=2)=C1 MXHPMGJFJIDBMB-UHFFFAOYSA-N 0.000 claims 1
QLYCBVKEEVUEJM-UHFFFAOYSA-N 1-[2-(1,3-benzothiazol-5-yl)-5-tert-butylpyrazol-3-yl]-3-[4-methyl-3-[8-methyl-2-(methylamino)-7-oxopyrido[2,3-d]pyrimidin-6-yl]phenyl]urea Chemical compound C1=C2SC=NC2=CC(N2N=C(C=C2NC(=O)NC=2C=C(C(=CC=2)C)C2=CC3=CN=C(N=C3N(C)C2=O)NC)C(C)(C)C)=C1 QLYCBVKEEVUEJM-UHFFFAOYSA-N 0.000 claims 1
CMVQXMCIKHGSKN-UHFFFAOYSA-N 1-[2-(1,3-benzoxazol-5-yl)-5-propan-2-ylpyrazol-3-yl]-3-[2-fluoro-4-[2-(methanesulfonamido)pyridin-4-yl]oxyphenyl]urea Chemical compound C=1C=C2OC=NC2=CC=1N1N=C(C(C)C)C=C1NC(=O)NC(C(=C1)F)=CC=C1OC1=CC=NC(NS(C)(=O)=O)=C1 CMVQXMCIKHGSKN-UHFFFAOYSA-N 0.000 claims 1
JGWFFFREDRPGLV-UHFFFAOYSA-N 1-[2-(1,3-benzoxazol-5-yl)-5-propan-2-ylpyrazol-3-yl]-3-[2-fluoro-4-[2-(propan-2-ylamino)pyridin-4-yl]oxyphenyl]urea Chemical compound C1=NC(NC(C)C)=CC(OC=2C=C(F)C(NC(=O)NC=3N(N=C(C=3)C(C)C)C=3C=C4N=COC4=CC=3)=CC=2)=C1 JGWFFFREDRPGLV-UHFFFAOYSA-N 0.000 claims 1
JPBWIPMORXPRRY-UHFFFAOYSA-N 1-[2-(1,3-benzoxazol-5-yl)-5-propan-2-ylpyrazol-3-yl]-3-[4-[2-(methanesulfonamido)pyridin-4-yl]oxyphenyl]urea Chemical compound C=1C=C2OC=NC2=CC=1N1N=C(C(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC1=CC=NC(NS(C)(=O)=O)=C1 JPBWIPMORXPRRY-UHFFFAOYSA-N 0.000 claims 1
JRZWMMWALNNYAR-UHFFFAOYSA-N 1-[2-(1,3-benzoxazol-5-yl)-5-propan-2-ylpyrazol-3-yl]-3-[4-[2-(propan-2-ylamino)pyridin-4-yl]oxyphenyl]urea Chemical compound C1=NC(NC(C)C)=CC(OC=2C=CC(NC(=O)NC=3N(N=C(C=3)C(C)C)C=3C=C4N=COC4=CC=3)=CC=2)=C1 JRZWMMWALNNYAR-UHFFFAOYSA-N 0.000 claims 1
CJLDSEGQHLAYIW-UHFFFAOYSA-N 1-[2-(1,3-benzoxazol-5-yl)-5-tert-butylpyrazol-3-yl]-3-[2-fluoro-4-[2-(1h-pyrazol-4-yl)pyridin-4-yl]oxyphenyl]urea Chemical compound C=1C=C2OC=NC2=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)NC(C(=C1)F)=CC=C1OC(C=1)=CC=NC=1C=1C=NNC=1 CJLDSEGQHLAYIW-UHFFFAOYSA-N 0.000 claims 1
NSJCXZXYYJBMHL-UHFFFAOYSA-N 1-[2-(1,3-benzoxazol-5-yl)-5-tert-butylpyrazol-3-yl]-3-[2-fluoro-4-[2-(methanesulfonamido)pyridin-4-yl]oxyphenyl]urea Chemical compound C=1C=C2OC=NC2=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)NC(C(=C1)F)=CC=C1OC1=CC=NC(NS(C)(=O)=O)=C1 NSJCXZXYYJBMHL-UHFFFAOYSA-N 0.000 claims 1
ZKXATBSAKSDDQE-UHFFFAOYSA-N 1-[2-(1,3-benzoxazol-5-yl)-5-tert-butylpyrazol-3-yl]-3-[2-fluoro-5-(1-oxo-2,3-dihydroisoindol-4-yl)phenyl]urea Chemical compound C1=C2OC=NC2=CC(N2C(NC(=O)NC=3C(=CC=C(C=3)C=3C=4CNC(=O)C=4C=CC=3)F)=CC(=N2)C(C)(C)C)=C1 ZKXATBSAKSDDQE-UHFFFAOYSA-N 0.000 claims 1
USRSHTOWTVMZOO-UHFFFAOYSA-N 1-[2-(1,3-benzoxazol-5-yl)-5-tert-butylpyrazol-3-yl]-3-[2-fluoro-5-[8-methyl-2-(methylamino)-7-oxopyrido[2,3-d]pyrimidin-6-yl]phenyl]urea Chemical compound C1=C2OC=NC2=CC(N2N=C(C=C2NC(=O)NC=2C(F)=CC=C(C=2)C2=CC3=CN=C(N=C3N(C)C2=O)NC)C(C)(C)C)=C1 USRSHTOWTVMZOO-UHFFFAOYSA-N 0.000 claims 1
DSKWDJJQQRVQLK-UHFFFAOYSA-N 1-[2-(1,3-benzoxazol-5-yl)-5-tert-butylpyrazol-3-yl]-3-[3-(1-oxo-2,3-dihydroisoindol-4-yl)phenyl]urea Chemical compound C1=C2OC=NC2=CC(N2C(NC(=O)NC=3C=C(C=CC=3)C=3C=4CNC(=O)C=4C=CC=3)=CC(=N2)C(C)(C)C)=C1 DSKWDJJQQRVQLK-UHFFFAOYSA-N 0.000 claims 1
IEQXRGRPQUWDJY-UHFFFAOYSA-N 1-[2-(1,3-benzoxazol-5-yl)-5-tert-butylpyrazol-3-yl]-3-[4-[2-(propan-2-ylamino)pyridin-4-yl]oxyphenyl]urea Chemical compound C1=NC(NC(C)C)=CC(OC=2C=CC(NC(=O)NC=3N(N=C(C=3)C(C)(C)C)C=3C=C4N=COC4=CC=3)=CC=2)=C1 IEQXRGRPQUWDJY-UHFFFAOYSA-N 0.000 claims 1
CXPRXIMUFUNKSQ-UHFFFAOYSA-N 1-[2-(1h-indazol-5-yl)-5-propan-2-ylpyrazol-3-yl]-3-[4-[2-(1h-pyrazol-4-yl)pyridin-4-yl]oxyphenyl]urea Chemical compound C=1C=C2NN=CC2=CC=1N1N=C(C(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC(C=1)=CC=NC=1C=1C=NNC=1 CXPRXIMUFUNKSQ-UHFFFAOYSA-N 0.000 claims 1
YMPOFIMOORTQKD-UHFFFAOYSA-N 1-[2-(1h-indazol-5-yl)-5-propan-2-ylpyrazol-3-yl]-3-[4-[2-(methanesulfonamido)pyridin-4-yl]oxyphenyl]urea Chemical compound C=1C=C2NN=CC2=CC=1N1N=C(C(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC1=CC=NC(NS(C)(=O)=O)=C1 YMPOFIMOORTQKD-UHFFFAOYSA-N 0.000 claims 1
IWYUKJRNHOVVQH-UHFFFAOYSA-N 1-[2-(2-methyl-3,4-dihydro-1h-isoquinolin-6-yl)-5-propan-2-ylpyrazol-3-yl]-3-[4-[2-(1-methylpyrazol-4-yl)pyridin-4-yl]oxyphenyl]urea Chemical compound C=1C=C2CN(C)CCC2=CC=1N1N=C(C(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC(C=1)=CC=NC=1C=1C=NN(C)C=1 IWYUKJRNHOVVQH-UHFFFAOYSA-N 0.000 claims 1
XRAVVXQTUNWHLL-UHFFFAOYSA-N 1-[2-(2-methyl-3,4-dihydro-1h-isoquinolin-6-yl)-5-propan-2-ylpyrazol-3-yl]-3-[4-[2-(propan-2-ylamino)pyridin-4-yl]oxyphenyl]urea Chemical compound C1=NC(NC(C)C)=CC(OC=2C=CC(NC(=O)NC=3N(N=C(C=3)C(C)C)C=3C=C4CCN(C)CC4=CC=3)=CC=2)=C1 XRAVVXQTUNWHLL-UHFFFAOYSA-N 0.000 claims 1
MCKQSYXDWNZQLD-UHFFFAOYSA-N 1-[2-(2-methyl-3,4-dihydro-1h-isoquinolin-7-yl)-5-propan-2-ylpyrazol-3-yl]-3-[4-[2-(1h-pyrazol-4-yl)pyridin-4-yl]oxyphenyl]urea Chemical compound C=1C=C2CCN(C)CC2=CC=1N1N=C(C(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC(C=1)=CC=NC=1C=1C=NNC=1 MCKQSYXDWNZQLD-UHFFFAOYSA-N 0.000 claims 1
LMRDIDIYHMAGGO-UHFFFAOYSA-N 1-[2-(2-methyl-3,4-dihydro-1h-isoquinolin-7-yl)-5-propan-2-ylpyrazol-3-yl]-3-[4-[2-(propan-2-ylamino)pyridin-4-yl]oxyphenyl]urea Chemical compound C1=NC(NC(C)C)=CC(OC=2C=CC(NC(=O)NC=3N(N=C(C=3)C(C)C)C=3C=C4CN(C)CCC4=CC=3)=CC=2)=C1 LMRDIDIYHMAGGO-UHFFFAOYSA-N 0.000 claims 1
GSWJSTUXIMEXDR-UHFFFAOYSA-N 1-[2-(3-cyanophenyl)-5-propan-2-ylpyrazol-3-yl]-3-[2-fluoro-4-[2-(1-methylpyrazol-4-yl)pyridin-4-yl]oxyphenyl]urea Chemical compound C=1C=CC(C#N)=CC=1N1N=C(C(C)C)C=C1NC(=O)NC(C(=C1)F)=CC=C1OC(C=1)=CC=NC=1C=1C=NN(C)C=1 GSWJSTUXIMEXDR-UHFFFAOYSA-N 0.000 claims 1
OCSUMBURDRBZPO-UHFFFAOYSA-N 1-[2-(3-cyanophenyl)-5-propan-2-ylpyrazol-3-yl]-3-[2-fluoro-4-[2-(1h-pyrazol-4-yl)pyridin-4-yl]oxyphenyl]urea Chemical compound C=1C=CC(C#N)=CC=1N1N=C(C(C)C)C=C1NC(=O)NC(C(=C1)F)=CC=C1OC(C=1)=CC=NC=1C=1C=NNC=1 OCSUMBURDRBZPO-UHFFFAOYSA-N 0.000 claims 1
UTECISGFSOLSDF-UHFFFAOYSA-N 1-[2-(3-cyanophenyl)-5-propan-2-ylpyrazol-3-yl]-3-[2-fluoro-4-methyl-5-[2-(methylamino)-7-oxo-8-propan-2-ylpyrido[2,3-d]pyrimidin-6-yl]phenyl]urea Chemical compound O=C1N(C(C)C)C2=NC(NC)=NC=C2C=C1C(C(=CC=1F)C)=CC=1NC(=O)NC1=CC(C(C)C)=NN1C1=CC=CC(C#N)=C1 UTECISGFSOLSDF-UHFFFAOYSA-N 0.000 claims 1
QGEFZGTWMSPZCT-UHFFFAOYSA-N 1-[2-(3-cyanophenyl)-5-propan-2-ylpyrazol-3-yl]-3-[2-fluoro-5-[8-methyl-2-(methylamino)-7-oxopyrido[2,3-d]pyrimidin-6-yl]phenyl]urea Chemical compound O=C1N(C)C2=NC(NC)=NC=C2C=C1C(C=1)=CC=C(F)C=1NC(=O)NC1=CC(C(C)C)=NN1C1=CC=CC(C#N)=C1 QGEFZGTWMSPZCT-UHFFFAOYSA-N 0.000 claims 1
NTTXWDNLVRVOBF-UHFFFAOYSA-N 1-[2-(3-cyanophenyl)-5-propan-2-ylpyrazol-3-yl]-3-[4-[2-(1-methylpyrazol-4-yl)pyridin-4-yl]oxyphenyl]urea Chemical compound C=1C=CC(C#N)=CC=1N1N=C(C(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC(C=1)=CC=NC=1C=1C=NN(C)C=1 NTTXWDNLVRVOBF-UHFFFAOYSA-N 0.000 claims 1
YBKXKDRMZYYVAT-UHFFFAOYSA-N 1-[2-(3-cyanophenyl)-5-propan-2-ylpyrazol-3-yl]-3-[5-[8-cyclopentyl-2-(methylamino)-7-oxopyrido[2,3-d]pyrimidin-6-yl]-2-fluorophenyl]urea Chemical compound O=C1N(C2CCCC2)C2=NC(NC)=NC=C2C=C1C(C=1)=CC=C(F)C=1NC(=O)NC1=CC(C(C)C)=NN1C1=CC=CC(C#N)=C1 YBKXKDRMZYYVAT-UHFFFAOYSA-N 0.000 claims 1
ZKCBPGBXLJPJNR-UHFFFAOYSA-N 1-[2-(3-fluorophenyl)-5-propan-2-ylpyrazol-3-yl]-3-[2-fluoro-4-[2-(1h-pyrazol-4-yl)pyridin-4-yl]oxyphenyl]urea Chemical compound C=1C=CC(F)=CC=1N1N=C(C(C)C)C=C1NC(=O)NC(C(=C1)F)=CC=C1OC(C=1)=CC=NC=1C=1C=NNC=1 ZKCBPGBXLJPJNR-UHFFFAOYSA-N 0.000 claims 1
RIYFOQMRYJWFBA-UHFFFAOYSA-N 1-[2-(3-fluorophenyl)-5-propan-2-ylpyrazol-3-yl]-3-[4-[2-(1-methylpyrazol-4-yl)pyridin-4-yl]oxyphenyl]urea Chemical compound C=1C=CC(F)=CC=1N1N=C(C(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC(C=1)=CC=NC=1C=1C=NN(C)C=1 RIYFOQMRYJWFBA-UHFFFAOYSA-N 0.000 claims 1
ZXHYKDWYDODKBC-UHFFFAOYSA-N 1-[2-(3h-benzimidazol-5-yl)-5-propan-2-ylpyrazol-3-yl]-3-[2-fluoro-4-[2-(1h-pyrazol-4-yl)pyridin-4-yl]oxyphenyl]urea Chemical compound C=1C=C2NC=NC2=CC=1N1N=C(C(C)C)C=C1NC(=O)NC(C(=C1)F)=CC=C1OC(C=1)=CC=NC=1C=1C=NNC=1 ZXHYKDWYDODKBC-UHFFFAOYSA-N 0.000 claims 1
GGCWQQSLRPBODL-UHFFFAOYSA-N 1-[2-(3h-benzimidazol-5-yl)-5-propan-2-ylpyrazol-3-yl]-3-[2-fluoro-4-[2-(methanesulfonamido)pyridin-4-yl]oxyphenyl]urea Chemical compound C=1C=C2NC=NC2=CC=1N1N=C(C(C)C)C=C1NC(=O)NC(C(=C1)F)=CC=C1OC1=CC=NC(NS(C)(=O)=O)=C1 GGCWQQSLRPBODL-UHFFFAOYSA-N 0.000 claims 1
BNJQDWJXQLOAIM-UHFFFAOYSA-N 1-[2-(3h-benzimidazol-5-yl)-5-propan-2-ylpyrazol-3-yl]-3-[4-[2-(methanesulfonamido)pyridin-4-yl]oxyphenyl]urea Chemical compound C=1C=C2NC=NC2=CC=1N1N=C(C(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC1=CC=NC(NS(C)(=O)=O)=C1 BNJQDWJXQLOAIM-UHFFFAOYSA-N 0.000 claims 1
BYQCBHAMSLBHNJ-UHFFFAOYSA-N 1-[2-(3h-benzimidazol-5-yl)-5-propan-2-ylpyrazol-3-yl]-3-[4-[2-(propan-2-ylamino)pyridin-4-yl]oxyphenyl]urea Chemical compound C1=NC(NC(C)C)=CC(OC=2C=CC(NC(=O)NC=3N(N=C(C=3)C(C)C)C=3C=C4N=CNC4=CC=3)=CC=2)=C1 BYQCBHAMSLBHNJ-UHFFFAOYSA-N 0.000 claims 1
YYJZYVNXCSRYHC-UHFFFAOYSA-N 1-[2-(3h-benzimidazol-5-yl)-5-tert-butylpyrazol-3-yl]-3-(2,3-dichlorophenyl)urea Chemical compound C=1C=C2N=CNC2=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)NC1=CC=CC(Cl)=C1Cl YYJZYVNXCSRYHC-UHFFFAOYSA-N 0.000 claims 1
WSIZLHRUYMWIAI-UHFFFAOYSA-N 1-[2-(3h-benzimidazol-5-yl)-5-tert-butylpyrazol-3-yl]-3-[2-fluoro-4-(1-oxo-2,3-dihydroisoindol-4-yl)phenyl]urea Chemical compound C1=C2NC=NC2=CC(N2C(NC(=O)NC=3C(=CC(=CC=3)C=3C=4CNC(=O)C=4C=CC=3)F)=CC(=N2)C(C)(C)C)=C1 WSIZLHRUYMWIAI-UHFFFAOYSA-N 0.000 claims 1
PWGMVBPZXLHQPC-UHFFFAOYSA-N 1-[2-(3h-benzimidazol-5-yl)-5-tert-butylpyrazol-3-yl]-3-[2-fluoro-4-[2-(1h-pyrazol-4-yl)pyridin-4-yl]oxyphenyl]urea Chemical compound C=1C=C2NC=NC2=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)NC(C(=C1)F)=CC=C1OC(C=1)=CC=NC=1C=1C=NNC=1 PWGMVBPZXLHQPC-UHFFFAOYSA-N 0.000 claims 1
YUVFNDTXLLGLJI-UHFFFAOYSA-N 1-[2-(3h-benzimidazol-5-yl)-5-tert-butylpyrazol-3-yl]-3-[2-fluoro-4-[2-(methanesulfonamido)pyridin-4-yl]oxyphenyl]urea Chemical compound C=1C=C2NC=NC2=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)NC(C(=C1)F)=CC=C1OC1=CC=NC(NS(C)(=O)=O)=C1 YUVFNDTXLLGLJI-UHFFFAOYSA-N 0.000 claims 1
QLARBHHNBINOMX-UHFFFAOYSA-N 1-[2-(3h-benzimidazol-5-yl)-5-tert-butylpyrazol-3-yl]-3-[2-fluoro-4-[2-(propan-2-ylamino)pyridin-4-yl]oxyphenyl]urea Chemical compound C1=NC(NC(C)C)=CC(OC=2C=C(F)C(NC(=O)NC=3N(N=C(C=3)C(C)(C)C)C=3C=C4N=CNC4=CC=3)=CC=2)=C1 QLARBHHNBINOMX-UHFFFAOYSA-N 0.000 claims 1
RCXAJJNGKWDAPG-UHFFFAOYSA-N 1-[2-(3h-benzimidazol-5-yl)-5-tert-butylpyrazol-3-yl]-3-[4-(1-oxo-2,3-dihydroisoindol-4-yl)phenyl]urea Chemical compound C1=C2N=CNC2=CC(N2C(NC(=O)NC=3C=CC(=CC=3)C=3C=4CNC(=O)C=4C=CC=3)=CC(=N2)C(C)(C)C)=C1 RCXAJJNGKWDAPG-UHFFFAOYSA-N 0.000 claims 1
XVYXLOWRVYNXHN-UHFFFAOYSA-N 1-[2-(3h-benzimidazol-5-yl)-5-tert-butylpyrazol-3-yl]-3-[4-[2-(1h-pyrazol-4-yl)pyridin-4-yl]oxyphenyl]urea Chemical compound C=1C=C2NC=NC2=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC(C=1)=CC=NC=1C=1C=NNC=1 XVYXLOWRVYNXHN-UHFFFAOYSA-N 0.000 claims 1
BQIHFNXOPRZHIX-UHFFFAOYSA-N 1-[2-(3h-benzimidazol-5-yl)-5-tert-butylpyrazol-3-yl]-3-[4-[2-(methanesulfonamido)pyridin-4-yl]oxyphenyl]urea Chemical compound C=1C=C2NC=NC2=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC1=CC=NC(NS(C)(=O)=O)=C1 BQIHFNXOPRZHIX-UHFFFAOYSA-N 0.000 claims 1
XHTDHOOQJUQKNQ-UHFFFAOYSA-N 1-[2-(3h-benzimidazol-5-yl)-5-tert-butylpyrazol-3-yl]-3-[4-[2-(propan-2-ylamino)pyridin-4-yl]oxyphenyl]urea Chemical compound C1=NC(NC(C)C)=CC(OC=2C=CC(NC(=O)NC=3N(N=C(C=3)C(C)(C)C)C=3C=C4N=CNC4=CC=3)=CC=2)=C1 XHTDHOOQJUQKNQ-UHFFFAOYSA-N 0.000 claims 1
ASEARZRMOGVGFQ-UHFFFAOYSA-N 1-[2-(4-cyanophenyl)-5-propan-2-ylpyrazol-3-yl]-3-[2-fluoro-4-methyl-5-[2-(methylamino)-7-oxo-8-propan-2-ylpyrido[2,3-d]pyrimidin-6-yl]phenyl]urea Chemical compound O=C1N(C(C)C)C2=NC(NC)=NC=C2C=C1C(C(=CC=1F)C)=CC=1NC(=O)NC1=CC(C(C)C)=NN1C1=CC=C(C#N)C=C1 ASEARZRMOGVGFQ-UHFFFAOYSA-N 0.000 claims 1
HFGGYJAQCDGFSK-UHFFFAOYSA-N 1-[2-(4-cyanophenyl)-5-propan-2-ylpyrazol-3-yl]-3-[2-fluoro-5-[2-(methylamino)-7-oxo-8-propan-2-ylpyrido[2,3-d]pyrimidin-6-yl]phenyl]urea Chemical compound O=C1N(C(C)C)C2=NC(NC)=NC=C2C=C1C(C=1)=CC=C(F)C=1NC(=O)NC1=CC(C(C)C)=NN1C1=CC=C(C#N)C=C1 HFGGYJAQCDGFSK-UHFFFAOYSA-N 0.000 claims 1
KXEAIPFKMOCNMS-UHFFFAOYSA-N 1-[2-(4-cyanophenyl)-5-propan-2-ylpyrazol-3-yl]-3-[4-[2-(1-methylpyrazol-4-yl)pyridin-4-yl]oxyphenyl]urea Chemical compound C=1C=C(C#N)C=CC=1N1N=C(C(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC(C=1)=CC=NC=1C=1C=NN(C)C=1 KXEAIPFKMOCNMS-UHFFFAOYSA-N 0.000 claims 1
PRIJLOFZQDXHMY-UHFFFAOYSA-N 1-[2-(4-cyanophenyl)-5-propan-2-ylpyrazol-3-yl]-3-[5-[8-cyclopentyl-2-(methylamino)-7-oxopyrido[2,3-d]pyrimidin-6-yl]-2-fluorophenyl]urea Chemical compound O=C1N(C2CCCC2)C2=NC(NC)=NC=C2C=C1C(C=1)=CC=C(F)C=1NC(=O)NC1=CC(C(C)C)=NN1C1=CC=C(C#N)C=C1 PRIJLOFZQDXHMY-UHFFFAOYSA-N 0.000 claims 1
IDRTUURZRJIGNA-UHFFFAOYSA-N 1-[2-(4-fluorophenyl)-5-propan-2-ylpyrazol-3-yl]-3-[4-[2-(1-methylpyrazol-4-yl)pyridin-4-yl]oxyphenyl]urea Chemical compound C=1C=C(F)C=CC=1N1N=C(C(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC(C=1)=CC=NC=1C=1C=NN(C)C=1 IDRTUURZRJIGNA-UHFFFAOYSA-N 0.000 claims 1
RBSSIDTXOUMGPM-UHFFFAOYSA-N 1-[2-(6-cyanopyridin-3-yl)-5-propan-2-ylpyrazol-3-yl]-3-[2-fluoro-4-[2-(1-methylpyrazol-4-yl)pyridin-4-yl]oxyphenyl]urea Chemical compound C=1C=C(C#N)N=CC=1N1N=C(C(C)C)C=C1NC(=O)NC(C(=C1)F)=CC=C1OC(C=1)=CC=NC=1C=1C=NN(C)C=1 RBSSIDTXOUMGPM-UHFFFAOYSA-N 0.000 claims 1
UJBHBERRAUFSSR-UHFFFAOYSA-N 1-[2-(6-cyanopyridin-3-yl)-5-propan-2-ylpyrazol-3-yl]-3-[2-fluoro-5-[8-methyl-2-(methylamino)-7-oxopyrido[2,3-d]pyrimidin-6-yl]phenyl]urea Chemical compound O=C1N(C)C2=NC(NC)=NC=C2C=C1C(C=1)=CC=C(F)C=1NC(=O)NC1=CC(C(C)C)=NN1C1=CC=C(C#N)N=C1 UJBHBERRAUFSSR-UHFFFAOYSA-N 0.000 claims 1
JNMCGZRGEVCSAS-UHFFFAOYSA-N 1-[2-(6-cyanopyridin-3-yl)-5-propan-2-ylpyrazol-3-yl]-3-[4-[2-(1-methylpyrazol-4-yl)pyridin-4-yl]oxyphenyl]urea Chemical compound C=1C=C(C#N)N=CC=1N1N=C(C(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC(C=1)=CC=NC=1C=1C=NN(C)C=1 JNMCGZRGEVCSAS-UHFFFAOYSA-N 0.000 claims 1
UCWQRMVMDPBTBG-UHFFFAOYSA-N 1-[2-ethyl-4-(3-fluorophenyl)pyrimidin-5-yl]-3-[2-fluoro-5-[2-(methylamino)-7-oxo-8-propan-2-ylpyrido[2,3-d]pyrimidin-6-yl]phenyl]urea Chemical compound N=1C(CC)=NC=C(NC(=O)NC=2C(=CC=C(C=2)C=2C(N(C(C)C)C3=NC(NC)=NC=C3C=2)=O)F)C=1C1=CC=CC(F)=C1 UCWQRMVMDPBTBG-UHFFFAOYSA-N 0.000 claims 1
FJXXVOGVNLUHNR-UHFFFAOYSA-N 1-[2-fluoro-4-[2-(1-methylpyrazol-4-yl)pyridin-4-yl]oxyphenyl]-3-(2-isoquinolin-6-yl-5-propan-2-ylpyrazol-3-yl)urea Chemical compound C=1C=C2C=NC=CC2=CC=1N1N=C(C(C)C)C=C1NC(=O)NC(C(=C1)F)=CC=C1OC(C=1)=CC=NC=1C=1C=NN(C)C=1 FJXXVOGVNLUHNR-UHFFFAOYSA-N 0.000 claims 1
DPBHZUDIDPTCLV-UHFFFAOYSA-N 1-[2-fluoro-4-[2-(1-methylpyrazol-4-yl)pyridin-4-yl]oxyphenyl]-3-(3-isoquinolin-6-yl-1-propan-2-ylpyrazol-4-yl)urea Chemical compound C=1C=C2C=NC=CC2=CC=1C1=NN(C(C)C)C=C1NC(=O)NC(C(=C1)F)=CC=C1OC(C=1)=CC=NC=1C=1C=NN(C)C=1 DPBHZUDIDPTCLV-UHFFFAOYSA-N 0.000 claims 1
WQESXRCYTAIHRL-UHFFFAOYSA-N 1-[2-fluoro-4-[2-(1-methylpyrazol-4-yl)pyridin-4-yl]oxyphenyl]-3-(5-propan-2-yl-2-quinazolin-6-ylpyrazol-3-yl)urea Chemical compound C=1C=C2N=CN=CC2=CC=1N1N=C(C(C)C)C=C1NC(=O)NC(C(=C1)F)=CC=C1OC(C=1)=CC=NC=1C=1C=NN(C)C=1 WQESXRCYTAIHRL-UHFFFAOYSA-N 0.000 claims 1
UEUJZGKZHBCAJO-UHFFFAOYSA-N 1-[2-fluoro-4-[2-(1-methylpyrazol-4-yl)pyridin-4-yl]oxyphenyl]-3-(5-propan-2-yl-2-quinolin-6-ylpyrazol-3-yl)urea Chemical compound C=1C=C2N=CC=CC2=CC=1N1N=C(C(C)C)C=C1NC(=O)NC(C(=C1)F)=CC=C1OC(C=1)=CC=NC=1C=1C=NN(C)C=1 UEUJZGKZHBCAJO-UHFFFAOYSA-N 0.000 claims 1
XEGSVCJSLWRVRL-UHFFFAOYSA-N 1-[2-fluoro-4-[2-(1-methylpyrazol-4-yl)pyridin-4-yl]oxyphenyl]-3-[2-(2-methyl-3,4-dihydro-1h-isoquinolin-7-yl)-5-propan-2-ylpyrazol-3-yl]urea Chemical compound C=1C=C2CCN(C)CC2=CC=1N1N=C(C(C)C)C=C1NC(=O)NC(C(=C1)F)=CC=C1OC(C=1)=CC=NC=1C=1C=NN(C)C=1 XEGSVCJSLWRVRL-UHFFFAOYSA-N 0.000 claims 1
KBHRBAYJHAEYEL-UHFFFAOYSA-N 1-[2-fluoro-4-[2-(1-methylpyrazol-4-yl)pyridin-4-yl]oxyphenyl]-3-[2-(3-fluorophenyl)-5-propan-2-ylpyrazol-3-yl]urea Chemical compound C=1C=CC(F)=CC=1N1N=C(C(C)C)C=C1NC(=O)NC(C(=C1)F)=CC=C1OC(C=1)=CC=NC=1C=1C=NN(C)C=1 KBHRBAYJHAEYEL-UHFFFAOYSA-N 0.000 claims 1
QJEIBIVQTNNGSW-UHFFFAOYSA-N 1-[2-fluoro-4-[2-(1-methylpyrazol-4-yl)pyridin-4-yl]oxyphenyl]-3-[2-(4-fluorophenyl)-5-propan-2-ylpyrazol-3-yl]urea Chemical compound C=1C=C(F)C=CC=1N1N=C(C(C)C)C=C1NC(=O)NC(C(=C1)F)=CC=C1OC(C=1)=CC=NC=1C=1C=NN(C)C=1 QJEIBIVQTNNGSW-UHFFFAOYSA-N 0.000 claims 1
AJNNETUSRGNRPG-UHFFFAOYSA-N 1-[2-fluoro-4-[2-(1-methylpyrazol-4-yl)pyridin-4-yl]oxyphenyl]-3-[3-(2-methyl-3,4-dihydro-1h-isoquinolin-6-yl)-1-propan-2-ylpyrazol-4-yl]urea Chemical compound C=1C=C2CN(C)CCC2=CC=1C1=NN(C(C)C)C=C1NC(=O)NC(C(=C1)F)=CC=C1OC(C=1)=CC=NC=1C=1C=NN(C)C=1 AJNNETUSRGNRPG-UHFFFAOYSA-N 0.000 claims 1
BRTFVKGZHBEVSH-UHFFFAOYSA-N 1-[2-fluoro-4-[2-(1-methylpyrazol-4-yl)pyridin-4-yl]oxyphenyl]-3-[3-(4-fluorophenyl)-1-propan-2-ylpyrazol-4-yl]urea Chemical compound C=1C=C(F)C=CC=1C1=NN(C(C)C)C=C1NC(=O)NC(C(=C1)F)=CC=C1OC(C=1)=CC=NC=1C=1C=NN(C)C=1 BRTFVKGZHBEVSH-UHFFFAOYSA-N 0.000 claims 1
ZGIWLBHATKWKLJ-UHFFFAOYSA-N 1-[2-fluoro-4-[2-(1-methylpyrazol-4-yl)pyridin-4-yl]oxyphenyl]-3-[5-propan-2-yl-2-(1,2,3,4-tetrahydroisoquinolin-6-yl)pyrazol-3-yl]urea Chemical compound C=1C=C2CNCCC2=CC=1N1N=C(C(C)C)C=C1NC(=O)NC(C(=C1)F)=CC=C1OC(C=1)=CC=NC=1C=1C=NN(C)C=1 ZGIWLBHATKWKLJ-UHFFFAOYSA-N 0.000 claims 1
QTCUIAYTEFKEKW-UHFFFAOYSA-N 1-[2-fluoro-4-[2-(1h-pyrazol-4-yl)pyridin-4-yl]oxyphenyl]-3-(3-isoquinolin-6-yl-1-propan-2-ylpyrazol-4-yl)urea Chemical compound C=1C=C2C=NC=CC2=CC=1C1=NN(C(C)C)C=C1NC(=O)NC(C(=C1)F)=CC=C1OC(C=1)=CC=NC=1C=1C=NNC=1 QTCUIAYTEFKEKW-UHFFFAOYSA-N 0.000 claims 1
JCEPUJXPQWWXDA-UHFFFAOYSA-N 1-[2-fluoro-4-[2-(1h-pyrazol-4-yl)pyridin-4-yl]oxyphenyl]-3-[2-(2-methyl-3,4-dihydro-1h-isoquinolin-6-yl)-5-propan-2-ylpyrazol-3-yl]urea Chemical compound C=1C=C2CN(C)CCC2=CC=1N1N=C(C(C)C)C=C1NC(=O)NC(C(=C1)F)=CC=C1OC(C=1)=CC=NC=1C=1C=NNC=1 JCEPUJXPQWWXDA-UHFFFAOYSA-N 0.000 claims 1
DEPWJSHNJSFKGC-UHFFFAOYSA-N 1-[2-fluoro-4-[2-(1h-pyrazol-4-yl)pyridin-4-yl]oxyphenyl]-3-[2-(2-methyl-3,4-dihydro-1h-isoquinolin-7-yl)-5-propan-2-ylpyrazol-3-yl]urea Chemical compound C=1C=C2CCN(C)CC2=CC=1N1N=C(C(C)C)C=C1NC(=O)NC(C(=C1)F)=CC=C1OC(C=1)=CC=NC=1C=1C=NNC=1 DEPWJSHNJSFKGC-UHFFFAOYSA-N 0.000 claims 1
UNZMUNGKGPOINR-UHFFFAOYSA-N 1-[2-fluoro-4-[2-(1h-pyrazol-4-yl)pyridin-4-yl]oxyphenyl]-3-[5-propan-2-yl-2-(1,2,3,4-tetrahydroisoquinolin-6-yl)pyrazol-3-yl]urea Chemical compound C=1C=C2CNCCC2=CC=1N1N=C(C(C)C)C=C1NC(=O)NC(C(=C1)F)=CC=C1OC(C=1)=CC=NC=1C=1C=NNC=1 UNZMUNGKGPOINR-UHFFFAOYSA-N 0.000 claims 1
ACKXVBWEABVBLD-UHFFFAOYSA-N 1-[2-fluoro-4-[2-(methanesulfonamido)pyridin-4-yl]oxyphenyl]-3-(2-isoquinolin-6-yl-5-propan-2-ylpyrazol-3-yl)urea Chemical compound C=1C=C2C=NC=CC2=CC=1N1N=C(C(C)C)C=C1NC(=O)NC(C(=C1)F)=CC=C1OC1=CC=NC(NS(C)(=O)=O)=C1 ACKXVBWEABVBLD-UHFFFAOYSA-N 0.000 claims 1
XYXVPGMOXTXOFS-UHFFFAOYSA-N 1-[2-fluoro-4-[2-(methanesulfonamido)pyridin-4-yl]oxyphenyl]-3-(3-isoquinolin-6-yl-1-propan-2-ylpyrazol-4-yl)urea Chemical compound C=1C=C2C=NC=CC2=CC=1C1=NN(C(C)C)C=C1NC(=O)NC(C(=C1)F)=CC=C1OC1=CC=NC(NS(C)(=O)=O)=C1 XYXVPGMOXTXOFS-UHFFFAOYSA-N 0.000 claims 1
QFEDRHWBQXXCTE-UHFFFAOYSA-N 1-[2-fluoro-4-[2-(methanesulfonamido)pyridin-4-yl]oxyphenyl]-3-(5-propan-2-yl-2-quinolin-6-ylpyrazol-3-yl)urea Chemical compound C=1C=C2N=CC=CC2=CC=1N1N=C(C(C)C)C=C1NC(=O)NC(C(=C1)F)=CC=C1OC1=CC=NC(NS(C)(=O)=O)=C1 QFEDRHWBQXXCTE-UHFFFAOYSA-N 0.000 claims 1
LYDORXPTVJFFDV-UHFFFAOYSA-N 1-[2-fluoro-4-[2-(methanesulfonamido)pyridin-4-yl]oxyphenyl]-3-[2-(2-methyl-3,4-dihydro-1h-isoquinolin-6-yl)-5-propan-2-ylpyrazol-3-yl]urea Chemical compound C=1C=C2CN(C)CCC2=CC=1N1N=C(C(C)C)C=C1NC(=O)NC(C(=C1)F)=CC=C1OC1=CC=NC(NS(C)(=O)=O)=C1 LYDORXPTVJFFDV-UHFFFAOYSA-N 0.000 claims 1
JWKTXINRSVHJKL-UHFFFAOYSA-N 1-[2-fluoro-4-[2-(methanesulfonamido)pyridin-4-yl]oxyphenyl]-3-[3-(1h-indazol-5-yl)-1-propan-2-ylpyrazol-4-yl]urea Chemical compound C=1C=C2NN=CC2=CC=1C1=NN(C(C)C)C=C1NC(=O)NC(C(=C1)F)=CC=C1OC1=CC=NC(NS(C)(=O)=O)=C1 JWKTXINRSVHJKL-UHFFFAOYSA-N 0.000 claims 1
RTEOAXNNPCRXCQ-UHFFFAOYSA-N 1-[2-fluoro-4-[2-(methanesulfonamido)pyridin-4-yl]oxyphenyl]-3-[3-(2-methyl-3,4-dihydro-1h-isoquinolin-6-yl)-1-propan-2-ylpyrazol-4-yl]urea Chemical compound C=1C=C2CN(C)CCC2=CC=1C1=NN(C(C)C)C=C1NC(=O)NC(C(=C1)F)=CC=C1OC1=CC=NC(NS(C)(=O)=O)=C1 RTEOAXNNPCRXCQ-UHFFFAOYSA-N 0.000 claims 1
FNKOWEYWLSGGBO-UHFFFAOYSA-N 1-[2-fluoro-4-[2-(methanesulfonamido)pyridin-4-yl]oxyphenyl]-3-[3-(2-methyl-3,4-dihydro-1h-isoquinolin-7-yl)-1-propan-2-ylpyrazol-4-yl]urea Chemical compound C=1C=C2CCN(C)CC2=CC=1C1=NN(C(C)C)C=C1NC(=O)NC(C(=C1)F)=CC=C1OC1=CC=NC(NS(C)(=O)=O)=C1 FNKOWEYWLSGGBO-UHFFFAOYSA-N 0.000 claims 1
GSNUQSYYSCLSJN-UHFFFAOYSA-N 1-[2-fluoro-4-[2-(methanesulfonamido)pyridin-4-yl]oxyphenyl]-3-[5-propan-2-yl-2-(1,2,3,4-tetrahydroisoquinolin-6-yl)pyrazol-3-yl]urea Chemical compound C=1C=C2CNCCC2=CC=1N1N=C(C(C)C)C=C1NC(=O)NC(C(=C1)F)=CC=C1OC1=CC=NC(NS(C)(=O)=O)=C1 GSNUQSYYSCLSJN-UHFFFAOYSA-N 0.000 claims 1
UZPJSWHKQIHNER-UHFFFAOYSA-N 1-[2-fluoro-4-[2-(propan-2-ylamino)pyridin-4-yl]oxyphenyl]-3-(1-propan-2-yl-3-quinolin-6-ylpyrazol-4-yl)urea Chemical compound C1=NC(NC(C)C)=CC(OC=2C=C(F)C(NC(=O)NC=3C(=NN(C=3)C(C)C)C=3C=C4C=CC=NC4=CC=3)=CC=2)=C1 UZPJSWHKQIHNER-UHFFFAOYSA-N 0.000 claims 1
CKVRAVMBEXOUTI-UHFFFAOYSA-N 1-[2-fluoro-4-[2-(propan-2-ylamino)pyridin-4-yl]oxyphenyl]-3-(2-isoquinolin-6-yl-5-propan-2-ylpyrazol-3-yl)urea Chemical compound C1=NC(NC(C)C)=CC(OC=2C=C(F)C(NC(=O)NC=3N(N=C(C=3)C(C)C)C=3C=C4C=CN=CC4=CC=3)=CC=2)=C1 CKVRAVMBEXOUTI-UHFFFAOYSA-N 0.000 claims 1
RIIWLUHSAOQRCH-UHFFFAOYSA-N 1-[2-fluoro-4-[2-(propan-2-ylamino)pyridin-4-yl]oxyphenyl]-3-(5-propan-2-yl-2-quinazolin-6-ylpyrazol-3-yl)urea Chemical compound C1=NC(NC(C)C)=CC(OC=2C=C(F)C(NC(=O)NC=3N(N=C(C=3)C(C)C)C=3C=C4C=NC=NC4=CC=3)=CC=2)=C1 RIIWLUHSAOQRCH-UHFFFAOYSA-N 0.000 claims 1
LFNXYVLWGULWNG-UHFFFAOYSA-N 1-[2-fluoro-4-[2-(propan-2-ylamino)pyridin-4-yl]oxyphenyl]-3-(5-propan-2-yl-2-quinolin-6-ylpyrazol-3-yl)urea Chemical compound C1=NC(NC(C)C)=CC(OC=2C=C(F)C(NC(=O)NC=3N(N=C(C=3)C(C)C)C=3C=C4C=CC=NC4=CC=3)=CC=2)=C1 LFNXYVLWGULWNG-UHFFFAOYSA-N 0.000 claims 1
LJVKMAKHBGYMIS-UHFFFAOYSA-N 1-[2-fluoro-4-[2-(propan-2-ylamino)pyridin-4-yl]oxyphenyl]-3-[3-(1h-indazol-5-yl)-1-propan-2-ylpyrazol-4-yl]urea Chemical compound C1=NC(NC(C)C)=CC(OC=2C=C(F)C(NC(=O)NC=3C(=NN(C=3)C(C)C)C=3C=C4C=NNC4=CC=3)=CC=2)=C1 LJVKMAKHBGYMIS-UHFFFAOYSA-N 0.000 claims 1
OGYABEJNSSLAEY-UHFFFAOYSA-N 1-[2-fluoro-4-[2-(propan-2-ylamino)pyridin-4-yl]oxyphenyl]-3-[3-(2-methyl-3,4-dihydro-1h-isoquinolin-6-yl)-1-propan-2-ylpyrazol-4-yl]urea Chemical compound C1=NC(NC(C)C)=CC(OC=2C=C(F)C(NC(=O)NC=3C(=NN(C=3)C(C)C)C=3C=C4CCN(C)CC4=CC=3)=CC=2)=C1 OGYABEJNSSLAEY-UHFFFAOYSA-N 0.000 claims 1
GZHBMEOCABFGQS-UHFFFAOYSA-N 1-[2-fluoro-4-[2-(propan-2-ylamino)pyridin-4-yl]oxyphenyl]-3-[5-propan-2-yl-2-(1,2,3,4-tetrahydroisoquinolin-6-yl)pyrazol-3-yl]urea Chemical compound C1=NC(NC(C)C)=CC(OC=2C=C(F)C(NC(=O)NC=3N(N=C(C=3)C(C)C)C=3C=C4CCNCC4=CC=3)=CC=2)=C1 GZHBMEOCABFGQS-UHFFFAOYSA-N 0.000 claims 1
DXEAQPPMEOEJAS-UHFFFAOYSA-N 1-[2-fluoro-4-methyl-5-[2-(methylamino)-7-oxo-8-propan-2-ylpyrido[2,3-d]pyrimidin-6-yl]phenyl]-3-(2-phenyl-5-propan-2-ylpyrazol-3-yl)urea Chemical compound O=C1N(C(C)C)C2=NC(NC)=NC=C2C=C1C(C(=CC=1F)C)=CC=1NC(=O)NC1=CC(C(C)C)=NN1C1=CC=CC=C1 DXEAQPPMEOEJAS-UHFFFAOYSA-N 0.000 claims 1
XHPIYAZJFHCPBO-UHFFFAOYSA-N 1-[2-fluoro-4-methyl-5-[2-(methylamino)-7-oxo-8-propan-2-ylpyrido[2,3-d]pyrimidin-6-yl]phenyl]-3-(3-phenyl-1-propan-2-ylpyrazol-4-yl)urea Chemical compound O=C1N(C(C)C)C2=NC(NC)=NC=C2C=C1C(C(=CC=1F)C)=CC=1NC(=O)NC1=CN(C(C)C)N=C1C1=CC=CC=C1 XHPIYAZJFHCPBO-UHFFFAOYSA-N 0.000 claims 1
ZFCTVXOMRLKLRX-UHFFFAOYSA-N 1-[2-fluoro-4-methyl-5-[2-(methylamino)-7-oxo-8-propan-2-ylpyrido[2,3-d]pyrimidin-6-yl]phenyl]-3-[2-(4-fluorophenyl)-5-propan-2-ylpyrazol-3-yl]urea Chemical compound O=C1N(C(C)C)C2=NC(NC)=NC=C2C=C1C(C(=CC=1F)C)=CC=1NC(=O)NC1=CC(C(C)C)=NN1C1=CC=C(F)C=C1 ZFCTVXOMRLKLRX-UHFFFAOYSA-N 0.000 claims 1
UWVNXJKCQJPRPX-UHFFFAOYSA-N 1-[2-fluoro-4-methyl-5-[2-(methylamino)-7-oxo-8-propan-2-ylpyrido[2,3-d]pyrimidin-6-yl]phenyl]-3-[3-(4-fluorophenyl)-1-propan-2-ylpyrazol-4-yl]urea Chemical compound O=C1N(C(C)C)C2=NC(NC)=NC=C2C=C1C(C(=CC=1F)C)=CC=1NC(=O)NC1=CN(C(C)C)N=C1C1=CC=C(F)C=C1 UWVNXJKCQJPRPX-UHFFFAOYSA-N 0.000 claims 1
IDSQYGZJPRDTRK-UHFFFAOYSA-N 1-[2-fluoro-5-[2-(methylamino)-7-oxo-8-propan-2-ylpyrido[2,3-d]pyrimidin-6-yl]phenyl]-3-(2-phenyl-5-propan-2-ylpyrazol-3-yl)urea Chemical compound O=C1N(C(C)C)C2=NC(NC)=NC=C2C=C1C(C=1)=CC=C(F)C=1NC(=O)NC1=CC(C(C)C)=NN1C1=CC=CC=C1 IDSQYGZJPRDTRK-UHFFFAOYSA-N 0.000 claims 1
QHAPCHYEQYHGEY-UHFFFAOYSA-N 1-[2-fluoro-5-[2-(methylamino)-7-oxo-8-propan-2-ylpyrido[2,3-d]pyrimidin-6-yl]phenyl]-3-(5-propan-2-yl-2-pyridin-3-ylpyrazol-3-yl)urea Chemical compound O=C1N(C(C)C)C2=NC(NC)=NC=C2C=C1C(C=1)=CC=C(F)C=1NC(=O)NC1=CC(C(C)C)=NN1C1=CC=CN=C1 QHAPCHYEQYHGEY-UHFFFAOYSA-N 0.000 claims 1
YIIROSHOHMPSQW-UHFFFAOYSA-N 1-[2-fluoro-5-[2-(methylamino)-7-oxo-8-propan-2-ylpyrido[2,3-d]pyrimidin-6-yl]phenyl]-3-[2-(3-fluorophenyl)-5-propan-2-ylpyrazol-3-yl]urea Chemical compound O=C1N(C(C)C)C2=NC(NC)=NC=C2C=C1C(C=1)=CC=C(F)C=1NC(=O)NC1=CC(C(C)C)=NN1C1=CC=CC(F)=C1 YIIROSHOHMPSQW-UHFFFAOYSA-N 0.000 claims 1
MGAWEVUQDBFROU-UHFFFAOYSA-N 1-[2-fluoro-5-[2-(methylamino)-7-oxo-8-propan-2-ylpyrido[2,3-d]pyrimidin-6-yl]phenyl]-3-[2-(4-fluorophenyl)-5-propan-2-ylpyrazol-3-yl]urea Chemical compound O=C1N(C(C)C)C2=NC(NC)=NC=C2C=C1C(C=1)=CC=C(F)C=1NC(=O)NC1=CC(C(C)C)=NN1C1=CC=C(F)C=C1 MGAWEVUQDBFROU-UHFFFAOYSA-N 0.000 claims 1
MGWKHCIMSXPBIN-UHFFFAOYSA-N 1-[2-fluoro-5-[2-(methylamino)-7-oxo-8-propan-2-ylpyrido[2,3-d]pyrimidin-6-yl]phenyl]-3-[3-(4-fluorophenyl)-1-propan-2-ylpyrazol-4-yl]urea Chemical compound O=C1N(C(C)C)C2=NC(NC)=NC=C2C=C1C(C=1)=CC=C(F)C=1NC(=O)NC1=CN(C(C)C)N=C1C1=CC=C(F)C=C1 MGWKHCIMSXPBIN-UHFFFAOYSA-N 0.000 claims 1
NUZMRQKQDGGPNZ-UHFFFAOYSA-N 1-[2-fluoro-5-[2-(methylamino)-7-oxo-8-propan-2-ylpyrido[2,3-d]pyrimidin-6-yl]phenyl]-3-[4-(3-fluorophenyl)-2-propan-2-ylpyrimidin-5-yl]urea Chemical compound O=C1N(C(C)C)C2=NC(NC)=NC=C2C=C1C(C=1)=CC=C(F)C=1NC(=O)NC1=CN=C(C(C)C)N=C1C1=CC=CC(F)=C1 NUZMRQKQDGGPNZ-UHFFFAOYSA-N 0.000 claims 1
DASOCSJKOBWOBD-UHFFFAOYSA-N 1-[2-fluoro-5-[8-(1-hydroxy-2-methylpropan-2-yl)-2-(methylamino)-7-oxopyrido[2,3-d]pyrimidin-6-yl]phenyl]-3-(2-phenyl-5-propan-2-ylpyrazol-3-yl)urea Chemical compound O=C1N(C(C)(C)CO)C2=NC(NC)=NC=C2C=C1C(C=1)=CC=C(F)C=1NC(=O)NC1=CC(C(C)C)=NN1C1=CC=CC=C1 DASOCSJKOBWOBD-UHFFFAOYSA-N 0.000 claims 1
LJLLHAYMFHQFQZ-UHFFFAOYSA-N 1-[2-fluoro-5-[8-(1-hydroxy-2-methylpropan-2-yl)-2-(methylamino)-7-oxopyrido[2,3-d]pyrimidin-6-yl]phenyl]-3-[2-(4-fluorophenyl)-5-propan-2-ylpyrazol-3-yl]urea Chemical compound O=C1N(C(C)(C)CO)C2=NC(NC)=NC=C2C=C1C(C=1)=CC=C(F)C=1NC(=O)NC1=CC(C(C)C)=NN1C1=CC=C(F)C=C1 LJLLHAYMFHQFQZ-UHFFFAOYSA-N 0.000 claims 1
MYXQEADUGLSPCS-UHFFFAOYSA-N 1-[2-fluoro-5-[8-methyl-2-(methylamino)-7-oxopyrido[2,3-d]pyrimidin-6-yl]phenyl]-3-(1-propan-2-yl-3-pyridin-3-ylpyrazol-4-yl)urea Chemical compound O=C1N(C)C2=NC(NC)=NC=C2C=C1C(C=1)=CC=C(F)C=1NC(=O)NC1=CN(C(C)C)N=C1C1=CC=CN=C1 MYXQEADUGLSPCS-UHFFFAOYSA-N 0.000 claims 1
UGOFJXRRZUKQDS-UHFFFAOYSA-N 1-[2-fluoro-5-[8-methyl-2-(methylamino)-7-oxopyrido[2,3-d]pyrimidin-6-yl]phenyl]-3-(2-phenyl-5-propan-2-ylpyrazol-3-yl)urea Chemical compound O=C1N(C)C2=NC(NC)=NC=C2C=C1C(C=1)=CC=C(F)C=1NC(=O)NC1=CC(C(C)C)=NN1C1=CC=CC=C1 UGOFJXRRZUKQDS-UHFFFAOYSA-N 0.000 claims 1
CJTMSSWVFQKILM-UHFFFAOYSA-N 1-[2-fluoro-5-[8-methyl-2-(methylamino)-7-oxopyrido[2,3-d]pyrimidin-6-yl]phenyl]-3-(3-phenyl-1-propan-2-ylpyrazol-4-yl)urea Chemical compound O=C1N(C)C2=NC(NC)=NC=C2C=C1C(C=1)=CC=C(F)C=1NC(=O)NC1=CN(C(C)C)N=C1C1=CC=CC=C1 CJTMSSWVFQKILM-UHFFFAOYSA-N 0.000 claims 1
QOJFJPSGMGSZCD-UHFFFAOYSA-N 1-[2-fluoro-5-[8-methyl-2-(methylamino)-7-oxopyrido[2,3-d]pyrimidin-6-yl]phenyl]-3-[2-(3-fluorophenyl)-5-propan-2-ylpyrazol-3-yl]urea Chemical compound O=C1N(C)C2=NC(NC)=NC=C2C=C1C(C=1)=CC=C(F)C=1NC(=O)NC1=CC(C(C)C)=NN1C1=CC=CC(F)=C1 QOJFJPSGMGSZCD-UHFFFAOYSA-N 0.000 claims 1
WNKFLRILHSTPRG-UHFFFAOYSA-N 1-[2-fluoro-5-[8-methyl-2-(methylamino)-7-oxopyrido[2,3-d]pyrimidin-6-yl]phenyl]-3-[3-(3-fluorophenyl)-1-propan-2-ylpyrazol-4-yl]urea Chemical compound O=C1N(C)C2=NC(NC)=NC=C2C=C1C(C=1)=CC=C(F)C=1NC(=O)NC1=CN(C(C)C)N=C1C1=CC=CC(F)=C1 WNKFLRILHSTPRG-UHFFFAOYSA-N 0.000 claims 1
OLRXSBMJRZDBFN-UHFFFAOYSA-N 1-[2-tert-butyl-4-(1,2-oxazol-4-yl)pyrimidin-5-yl]-3-[3-[8-methyl-2-(methylamino)-7-oxopyrido[2,3-d]pyrimidin-6-yl]phenyl]urea Chemical compound O=C1N(C)C2=NC(NC)=NC=C2C=C1C(C=1)=CC=CC=1NC(=O)NC1=CN=C(C(C)(C)C)N=C1C=1C=NOC=1 OLRXSBMJRZDBFN-UHFFFAOYSA-N 0.000 claims 1
DMHLTVDJNFZZKY-UHFFFAOYSA-N 1-[2-tert-butyl-4-(1,2-thiazol-4-yl)pyrimidin-5-yl]-3-[2-fluoro-5-[2-(methylamino)-7-oxo-8-propan-2-ylpyrido[2,3-d]pyrimidin-6-yl]phenyl]urea Chemical compound O=C1N(C(C)C)C2=NC(NC)=NC=C2C=C1C(C=1)=CC=C(F)C=1NC(=O)NC1=CN=C(C(C)(C)C)N=C1C=1C=NSC=1 DMHLTVDJNFZZKY-UHFFFAOYSA-N 0.000 claims 1
ROVLLNJSKLGTGH-UHFFFAOYSA-N 1-[2-tert-butyl-4-(1,3-thiazol-5-yl)pyrimidin-5-yl]-3-[2-fluoro-5-[2-(methylamino)-7-oxo-8-propan-2-ylpyrido[2,3-d]pyrimidin-6-yl]phenyl]urea Chemical compound O=C1N(C(C)C)C2=NC(NC)=NC=C2C=C1C(C=1)=CC=C(F)C=1NC(=O)NC1=CN=C(C(C)(C)C)N=C1C1=CN=CS1 ROVLLNJSKLGTGH-UHFFFAOYSA-N 0.000 claims 1
WWTKUKPSEYCWCU-UHFFFAOYSA-N 1-[2-tert-butyl-4-(1-methylindol-5-yl)pyrimidin-5-yl]-3-[2-fluoro-5-(8-methyl-7-oxopyrido[2,3-d]pyrimidin-6-yl)phenyl]urea Chemical compound N1=CN=C2N(C)C(=O)C(C=3C=C(C(=CC=3)F)NC(=O)NC3=CN=C(N=C3C=3C=C4C=CN(C4=CC=3)C)C(C)(C)C)=CC2=C1 WWTKUKPSEYCWCU-UHFFFAOYSA-N 0.000 claims 1
RQYOTOBLMDCDDE-UHFFFAOYSA-N 1-[2-tert-butyl-4-(1h-pyrazol-4-yl)pyrimidin-5-yl]-3-[3-[8-methyl-2-(methylamino)-7-oxopyrido[2,3-d]pyrimidin-6-yl]phenyl]urea Chemical compound O=C1N(C)C2=NC(NC)=NC=C2C=C1C(C=1)=CC=CC=1NC(=O)NC1=CN=C(C(C)(C)C)N=C1C=1C=NNC=1 RQYOTOBLMDCDDE-UHFFFAOYSA-N 0.000 claims 1
GGRQNAYKLCBAPP-UHFFFAOYSA-N 1-[2-tert-butyl-4-(3-fluorophenyl)pyrimidin-5-yl]-3-[2-fluoro-5-[2-(methylamino)-7-oxo-8-propan-2-ylpyrido[2,3-d]pyrimidin-6-yl]phenyl]urea Chemical compound O=C1N(C(C)C)C2=NC(NC)=NC=C2C=C1C(C=1)=CC=C(F)C=1NC(=O)NC1=CN=C(C(C)(C)C)N=C1C1=CC=CC(F)=C1 GGRQNAYKLCBAPP-UHFFFAOYSA-N 0.000 claims 1
KNOQFQPSEDJXSP-UHFFFAOYSA-N 1-[2-tert-butyl-4-(4-cyanophenyl)pyrimidin-5-yl]-3-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]urea Chemical compound C1=C(NC=2N=C(C=CN=2)C=2C=NC=CC=2)C(C)=CC=C1NC(=O)NC1=CN=C(C(C)(C)C)N=C1C1=CC=C(C#N)C=C1 KNOQFQPSEDJXSP-UHFFFAOYSA-N 0.000 claims 1
BSWIHLANGZLNPP-UHFFFAOYSA-N 1-[3-(1,2-benzoxazol-5-yl)-1-propan-2-ylpyrazol-4-yl]-3-[2-fluoro-4-[2-(1h-pyrazol-4-yl)pyridin-4-yl]oxyphenyl]urea Chemical compound C=1C=C2ON=CC2=CC=1C1=NN(C(C)C)C=C1NC(=O)NC(C(=C1)F)=CC=C1OC(C=1)=CC=NC=1C=1C=NNC=1 BSWIHLANGZLNPP-UHFFFAOYSA-N 0.000 claims 1
CSSXYLVNEMYHLF-UHFFFAOYSA-N 1-[3-(1,2-benzoxazol-5-yl)-1-propan-2-ylpyrazol-4-yl]-3-[2-fluoro-4-[2-(propan-2-ylamino)pyridin-4-yl]oxyphenyl]urea Chemical compound C1=NC(NC(C)C)=CC(OC=2C=C(F)C(NC(=O)NC=3C(=NN(C=3)C(C)C)C=3C=C4C=NOC4=CC=3)=CC=2)=C1 CSSXYLVNEMYHLF-UHFFFAOYSA-N 0.000 claims 1
KLKBIRAELUPNPS-UHFFFAOYSA-N 1-[3-(1,2-benzoxazol-5-yl)-1-propan-2-ylpyrazol-4-yl]-3-[4-[2-(1h-pyrazol-4-yl)pyridin-4-yl]oxyphenyl]urea Chemical compound C=1C=C2ON=CC2=CC=1C1=NN(C(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC(C=1)=CC=NC=1C=1C=NNC=1 KLKBIRAELUPNPS-UHFFFAOYSA-N 0.000 claims 1
HQDWTTMCYWIMKW-UHFFFAOYSA-N 1-[3-(1,2-benzoxazol-5-yl)-1-propan-2-ylpyrazol-4-yl]-3-[4-[2-(propan-2-ylamino)pyridin-4-yl]oxyphenyl]urea Chemical compound C1=NC(NC(C)C)=CC(OC=2C=CC(NC(=O)NC=3C(=NN(C=3)C(C)C)C=3C=C4C=NOC4=CC=3)=CC=2)=C1 HQDWTTMCYWIMKW-UHFFFAOYSA-N 0.000 claims 1
TUIRMBQPXHDCFP-UHFFFAOYSA-N 1-[3-(1,2-benzoxazol-5-yl)-1-tert-butylpyrazol-4-yl]-3-(2,3-dichlorophenyl)urea Chemical compound C=1C=C2ON=CC2=CC=1C1=NN(C(C)(C)C)C=C1NC(=O)NC1=CC=CC(Cl)=C1Cl TUIRMBQPXHDCFP-UHFFFAOYSA-N 0.000 claims 1
PHXKSGOBNRVWKB-UHFFFAOYSA-N 1-[3-(1,2-benzoxazol-5-yl)-1-tert-butylpyrazol-4-yl]-3-[2-fluoro-4-(1-oxo-2,3-dihydroisoindol-4-yl)phenyl]urea Chemical compound C1=C2ON=CC2=CC(C=2C(NC(=O)NC=3C(=CC(=CC=3)C=3C=4CNC(=O)C=4C=CC=3)F)=CN(N=2)C(C)(C)C)=C1 PHXKSGOBNRVWKB-UHFFFAOYSA-N 0.000 claims 1
YYEMIJRNKDWAQB-UHFFFAOYSA-N 1-[3-(1,2-benzoxazol-5-yl)-1-tert-butylpyrazol-4-yl]-3-[2-fluoro-4-[2-(1h-pyrazol-4-yl)pyridin-4-yl]oxyphenyl]urea Chemical compound C=1C=C2ON=CC2=CC=1C1=NN(C(C)(C)C)C=C1NC(=O)NC(C(=C1)F)=CC=C1OC(C=1)=CC=NC=1C=1C=NNC=1 YYEMIJRNKDWAQB-UHFFFAOYSA-N 0.000 claims 1
AEDCHOOCMDHCRD-UHFFFAOYSA-N 1-[3-(1,2-benzoxazol-5-yl)-1-tert-butylpyrazol-4-yl]-3-[2-fluoro-4-[2-(propan-2-ylamino)pyridin-4-yl]oxyphenyl]urea Chemical compound C1=NC(NC(C)C)=CC(OC=2C=C(F)C(NC(=O)NC=3C(=NN(C=3)C(C)(C)C)C=3C=C4C=NOC4=CC=3)=CC=2)=C1 AEDCHOOCMDHCRD-UHFFFAOYSA-N 0.000 claims 1
RMRBIESARHHVMK-UHFFFAOYSA-N 1-[3-(1,2-benzoxazol-5-yl)-1-tert-butylpyrazol-4-yl]-3-[4-(1-oxo-2,3-dihydroisoindol-4-yl)phenyl]urea Chemical compound C1=C2ON=CC2=CC(C=2C(NC(=O)NC=3C=CC(=CC=3)C=3C=4CNC(=O)C=4C=CC=3)=CN(N=2)C(C)(C)C)=C1 RMRBIESARHHVMK-UHFFFAOYSA-N 0.000 claims 1
OZDVGLOLMRVVTN-UHFFFAOYSA-N 1-[3-(1,2-benzoxazol-5-yl)-1-tert-butylpyrazol-4-yl]-3-[4-[2-(1h-pyrazol-4-yl)pyridin-4-yl]oxyphenyl]urea Chemical compound C=1C=C2ON=CC2=CC=1C1=NN(C(C)(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC(C=1)=CC=NC=1C=1C=NNC=1 OZDVGLOLMRVVTN-UHFFFAOYSA-N 0.000 claims 1
SGJXUBCFLTTZQS-UHFFFAOYSA-N 1-[3-(1,2-benzoxazol-5-yl)-1-tert-butylpyrazol-4-yl]-3-[4-[2-(propan-2-ylamino)pyridin-4-yl]oxyphenyl]urea Chemical compound C1=NC(NC(C)C)=CC(OC=2C=CC(NC(=O)NC=3C(=NN(C=3)C(C)(C)C)C=3C=C4C=NOC4=CC=3)=CC=2)=C1 SGJXUBCFLTTZQS-UHFFFAOYSA-N 0.000 claims 1
URQABRDHZMXSTD-UHFFFAOYSA-N 1-[3-(1,3-benzothiazol-5-yl)-1-propan-2-ylpyrazol-4-yl]-3-[2-fluoro-4-(1-oxo-2,3-dihydroisoindol-4-yl)phenyl]urea Chemical compound C1=C2SC=NC2=CC(C=2C(NC(=O)NC=3C(=CC(=CC=3)C=3C=4CNC(=O)C=4C=CC=3)F)=CN(N=2)C(C)C)=C1 URQABRDHZMXSTD-UHFFFAOYSA-N 0.000 claims 1
ZPMXZPQTLVFSNU-UHFFFAOYSA-N 1-[3-(1,3-benzothiazol-5-yl)-1-propan-2-ylpyrazol-4-yl]-3-[2-fluoro-4-[2-(propan-2-ylamino)pyridin-4-yl]oxyphenyl]urea Chemical compound C1=NC(NC(C)C)=CC(OC=2C=C(F)C(NC(=O)NC=3C(=NN(C=3)C(C)C)C=3C=C4N=CSC4=CC=3)=CC=2)=C1 ZPMXZPQTLVFSNU-UHFFFAOYSA-N 0.000 claims 1
BMRZIXUMODKKJP-UHFFFAOYSA-N 1-[3-(1,3-benzothiazol-5-yl)-1-propan-2-ylpyrazol-4-yl]-3-[4-(1-oxo-2,3-dihydroisoindol-4-yl)phenyl]urea Chemical compound C1=C2SC=NC2=CC(C=2C(NC(=O)NC=3C=CC(=CC=3)C=3C=4CNC(=O)C=4C=CC=3)=CN(N=2)C(C)C)=C1 BMRZIXUMODKKJP-UHFFFAOYSA-N 0.000 claims 1
RSEABFDVWQMKQT-UHFFFAOYSA-N 1-[3-(1,3-benzothiazol-5-yl)-1-tert-butylpyrazol-4-yl]-3-(2,3-dichlorophenyl)urea Chemical compound C=1C=C2SC=NC2=CC=1C1=NN(C(C)(C)C)C=C1NC(=O)NC1=CC=CC(Cl)=C1Cl RSEABFDVWQMKQT-UHFFFAOYSA-N 0.000 claims 1
USWZARPCBGIREP-UHFFFAOYSA-N 1-[3-(1,3-benzothiazol-5-yl)-1-tert-butylpyrazol-4-yl]-3-[2-fluoro-4-[2-(methanesulfonamido)pyridin-4-yl]oxyphenyl]urea Chemical compound C=1C=C2SC=NC2=CC=1C1=NN(C(C)(C)C)C=C1NC(=O)NC(C(=C1)F)=CC=C1OC1=CC=NC(NS(C)(=O)=O)=C1 USWZARPCBGIREP-UHFFFAOYSA-N 0.000 claims 1
GKRZQJRHRQGVDK-UHFFFAOYSA-N 1-[3-(1,3-benzothiazol-5-yl)-1-tert-butylpyrazol-4-yl]-3-[2-fluoro-4-[2-(propan-2-ylamino)pyridin-4-yl]oxyphenyl]urea Chemical compound C1=NC(NC(C)C)=CC(OC=2C=C(F)C(NC(=O)NC=3C(=NN(C=3)C(C)(C)C)C=3C=C4N=CSC4=CC=3)=CC=2)=C1 GKRZQJRHRQGVDK-UHFFFAOYSA-N 0.000 claims 1
RTDRCUDOSCHKMO-UHFFFAOYSA-N 1-[3-(1,3-benzothiazol-5-yl)-1-tert-butylpyrazol-4-yl]-3-[4-[2-(methanesulfonamido)pyridin-4-yl]oxyphenyl]urea Chemical compound C=1C=C2SC=NC2=CC=1C1=NN(C(C)(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC1=CC=NC(NS(C)(=O)=O)=C1 RTDRCUDOSCHKMO-UHFFFAOYSA-N 0.000 claims 1
DWKMRKLXASPMMW-UHFFFAOYSA-N 1-[3-(1,3-benzoxazol-5-yl)-1-propan-2-ylpyrazol-4-yl]-3-[2-fluoro-4-[2-(1h-pyrazol-4-yl)pyridin-4-yl]oxyphenyl]urea Chemical compound C=1C=C2OC=NC2=CC=1C1=NN(C(C)C)C=C1NC(=O)NC(C(=C1)F)=CC=C1OC(C=1)=CC=NC=1C=1C=NNC=1 DWKMRKLXASPMMW-UHFFFAOYSA-N 0.000 claims 1
LXLRRZNMTDXSRF-UHFFFAOYSA-N 1-[3-(1,3-benzoxazol-5-yl)-1-propan-2-ylpyrazol-4-yl]-3-[2-fluoro-4-[2-(methanesulfonamido)pyridin-4-yl]oxyphenyl]urea Chemical compound C=1C=C2OC=NC2=CC=1C1=NN(C(C)C)C=C1NC(=O)NC(C(=C1)F)=CC=C1OC1=CC=NC(NS(C)(=O)=O)=C1 LXLRRZNMTDXSRF-UHFFFAOYSA-N 0.000 claims 1
ZZAQTRHRVNVTKG-UHFFFAOYSA-N 1-[3-(1,3-benzoxazol-5-yl)-1-propan-2-ylpyrazol-4-yl]-3-[2-fluoro-4-[2-(propan-2-ylamino)pyridin-4-yl]oxyphenyl]urea Chemical compound C1=NC(NC(C)C)=CC(OC=2C=C(F)C(NC(=O)NC=3C(=NN(C=3)C(C)C)C=3C=C4N=COC4=CC=3)=CC=2)=C1 ZZAQTRHRVNVTKG-UHFFFAOYSA-N 0.000 claims 1
ILLNTPAGOYQXJY-UHFFFAOYSA-N 1-[3-(1,3-benzoxazol-5-yl)-1-propan-2-ylpyrazol-4-yl]-3-[4-(1-oxo-2,3-dihydroisoindol-4-yl)phenyl]urea Chemical compound C1=C2OC=NC2=CC(C=2C(NC(=O)NC=3C=CC(=CC=3)C=3C=4CNC(=O)C=4C=CC=3)=CN(N=2)C(C)C)=C1 ILLNTPAGOYQXJY-UHFFFAOYSA-N 0.000 claims 1
POYGNDDCIUIUJH-UHFFFAOYSA-N 1-[3-(1,3-benzoxazol-5-yl)-1-tert-butylpyrazol-4-yl]-3-[2-fluoro-4-(1-oxo-2,3-dihydroisoindol-4-yl)phenyl]urea Chemical compound C1=C2OC=NC2=CC(C=2C(NC(=O)NC=3C(=CC(=CC=3)C=3C=4CNC(=O)C=4C=CC=3)F)=CN(N=2)C(C)(C)C)=C1 POYGNDDCIUIUJH-UHFFFAOYSA-N 0.000 claims 1
KYLBHHRORRMZIX-UHFFFAOYSA-N 1-[3-(1,3-benzoxazol-5-yl)-1-tert-butylpyrazol-4-yl]-3-[2-fluoro-4-[2-(1h-pyrazol-4-yl)pyridin-4-yl]oxyphenyl]urea Chemical compound C=1C=C2OC=NC2=CC=1C1=NN(C(C)(C)C)C=C1NC(=O)NC(C(=C1)F)=CC=C1OC(C=1)=CC=NC=1C=1C=NNC=1 KYLBHHRORRMZIX-UHFFFAOYSA-N 0.000 claims 1
PQUYQSMXJQYTTD-UHFFFAOYSA-N 1-[3-(1,3-benzoxazol-5-yl)-1-tert-butylpyrazol-4-yl]-3-[2-fluoro-4-[2-(methanesulfonamido)pyridin-4-yl]oxyphenyl]urea Chemical compound C=1C=C2OC=NC2=CC=1C1=NN(C(C)(C)C)C=C1NC(=O)NC(C(=C1)F)=CC=C1OC1=CC=NC(NS(C)(=O)=O)=C1 PQUYQSMXJQYTTD-UHFFFAOYSA-N 0.000 claims 1
YOUUEEMIIPESFB-UHFFFAOYSA-N 1-[3-(1,3-benzoxazol-5-yl)-1-tert-butylpyrazol-4-yl]-3-[2-fluoro-4-[2-(propan-2-ylamino)pyridin-4-yl]oxyphenyl]urea Chemical compound C1=NC(NC(C)C)=CC(OC=2C=C(F)C(NC(=O)NC=3C(=NN(C=3)C(C)(C)C)C=3C=C4N=COC4=CC=3)=CC=2)=C1 YOUUEEMIIPESFB-UHFFFAOYSA-N 0.000 claims 1
XMFQPSYOGOQXHE-UHFFFAOYSA-N 1-[3-(1,3-benzoxazol-5-yl)-1-tert-butylpyrazol-4-yl]-3-[2-fluoro-5-[8-methyl-2-(methylamino)-7-oxopyrido[2,3-d]pyrimidin-6-yl]phenyl]urea Chemical compound C1=C2OC=NC2=CC(C2=NN(C=C2NC(=O)NC=2C(F)=CC=C(C=2)C2=CC3=CN=C(N=C3N(C)C2=O)NC)C(C)(C)C)=C1 XMFQPSYOGOQXHE-UHFFFAOYSA-N 0.000 claims 1
AIKUVTCBUWYLHF-UHFFFAOYSA-N 1-[3-(1,3-benzoxazol-5-yl)-1-tert-butylpyrazol-4-yl]-3-[4-(1-oxo-2,3-dihydroisoindol-4-yl)phenyl]urea Chemical compound C1=C2OC=NC2=CC(C=2C(NC(=O)NC=3C=CC(=CC=3)C=3C=4CNC(=O)C=4C=CC=3)=CN(N=2)C(C)(C)C)=C1 AIKUVTCBUWYLHF-UHFFFAOYSA-N 0.000 claims 1
BPVOEYKMGHXNII-UHFFFAOYSA-N 1-[3-(1,3-benzoxazol-5-yl)-1-tert-butylpyrazol-4-yl]-3-[4-[2-(1h-pyrazol-4-yl)pyridin-4-yl]oxyphenyl]urea Chemical compound C=1C=C2OC=NC2=CC=1C1=NN(C(C)(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC(C=1)=CC=NC=1C=1C=NNC=1 BPVOEYKMGHXNII-UHFFFAOYSA-N 0.000 claims 1
SOOXLCWKTSITLA-UHFFFAOYSA-N 1-[3-(1h-indazol-5-yl)-1-propan-2-ylpyrazol-4-yl]-3-[4-[2-(1h-pyrazol-4-yl)pyridin-4-yl]oxyphenyl]urea Chemical compound C=1C=C2NN=CC2=CC=1C1=NN(C(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC(C=1)=CC=NC=1C=1C=NNC=1 SOOXLCWKTSITLA-UHFFFAOYSA-N 0.000 claims 1
LTWATCLQCCHQHP-UHFFFAOYSA-N 1-[3-(1h-indazol-5-yl)-1-propan-2-ylpyrazol-4-yl]-3-[4-[2-(propan-2-ylamino)pyridin-4-yl]oxyphenyl]urea Chemical compound C1=NC(NC(C)C)=CC(OC=2C=CC(NC(=O)NC=3C(=NN(C=3)C(C)C)C=3C=C4C=NNC4=CC=3)=CC=2)=C1 LTWATCLQCCHQHP-UHFFFAOYSA-N 0.000 claims 1
FKNKFMOKRTXEQU-UHFFFAOYSA-N 1-[3-(2-methyl-3,4-dihydro-1h-isoquinolin-6-yl)-1-propan-2-ylpyrazol-4-yl]-3-[4-[2-(1-methylpyrazol-4-yl)pyridin-4-yl]oxyphenyl]urea Chemical compound C=1C=C2CN(C)CCC2=CC=1C1=NN(C(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC(C=1)=CC=NC=1C=1C=NN(C)C=1 FKNKFMOKRTXEQU-UHFFFAOYSA-N 0.000 claims 1
QLJJKIQRPFHNDX-UHFFFAOYSA-N 1-[3-(2-methyl-3,4-dihydro-1h-isoquinolin-6-yl)-1-propan-2-ylpyrazol-4-yl]-3-[4-[2-(1h-pyrazol-4-yl)pyridin-4-yl]oxyphenyl]urea Chemical compound C=1C=C2CN(C)CCC2=CC=1C1=NN(C(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC(C=1)=CC=NC=1C=1C=NNC=1 QLJJKIQRPFHNDX-UHFFFAOYSA-N 0.000 claims 1
JECCPDGLIJPFTQ-UHFFFAOYSA-N 1-[3-(2-methyl-3,4-dihydro-1h-isoquinolin-7-yl)-1-propan-2-ylpyrazol-4-yl]-3-[4-[2-(1h-pyrazol-4-yl)pyridin-4-yl]oxyphenyl]urea Chemical compound C=1C=C2CCN(C)CC2=CC=1C1=NN(C(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC(C=1)=CC=NC=1C=1C=NNC=1 JECCPDGLIJPFTQ-UHFFFAOYSA-N 0.000 claims 1
HEBGLQHVMQFOBF-UHFFFAOYSA-N 1-[3-(3-cyanophenyl)-1-propan-2-ylpyrazol-4-yl]-3-[2-fluoro-4-[2-(1-methylpyrazol-4-yl)pyridin-4-yl]oxyphenyl]urea Chemical compound C=1C=CC(C#N)=CC=1C1=NN(C(C)C)C=C1NC(=O)NC(C(=C1)F)=CC=C1OC(C=1)=CC=NC=1C=1C=NN(C)C=1 HEBGLQHVMQFOBF-UHFFFAOYSA-N 0.000 claims 1
ULPHZCCARSLRLM-UHFFFAOYSA-N 1-[3-(3-cyanophenyl)-1-propan-2-ylpyrazol-4-yl]-3-[2-fluoro-5-[2-(methylamino)-7-oxo-8-propan-2-ylpyrido[2,3-d]pyrimidin-6-yl]phenyl]urea Chemical compound O=C1N(C(C)C)C2=NC(NC)=NC=C2C=C1C(C=1)=CC=C(F)C=1NC(=O)NC1=CN(C(C)C)N=C1C1=CC=CC(C#N)=C1 ULPHZCCARSLRLM-UHFFFAOYSA-N 0.000 claims 1
XCGHFWSHLVOABI-UHFFFAOYSA-N 1-[3-(3-fluorophenyl)-1-propan-2-ylpyrazol-4-yl]-3-[2-fluoro-4-[2-(1h-pyrazol-4-yl)pyridin-4-yl]oxyphenyl]urea Chemical compound C=1C=CC(F)=CC=1C1=NN(C(C)C)C=C1NC(=O)NC(C(=C1)F)=CC=C1OC(C=1)=CC=NC=1C=1C=NNC=1 XCGHFWSHLVOABI-UHFFFAOYSA-N 0.000 claims 1
YJMDYHUXOVYTPD-UHFFFAOYSA-N 1-[3-(3-fluorophenyl)-1-propan-2-ylpyrazol-4-yl]-3-[4-[2-(1h-pyrazol-4-yl)pyridin-4-yl]oxyphenyl]urea Chemical compound C=1C=CC(F)=CC=1C1=NN(C(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC(C=1)=CC=NC=1C=1C=NNC=1 YJMDYHUXOVYTPD-UHFFFAOYSA-N 0.000 claims 1
PLYYMDONYHTGKF-UHFFFAOYSA-N 1-[3-(3h-benzimidazol-5-yl)-1-propan-2-ylpyrazol-4-yl]-3-[2-fluoro-4-(1-oxo-2,3-dihydroisoindol-4-yl)phenyl]urea Chemical compound C1=C2NC=NC2=CC(C=2C(NC(=O)NC=3C(=CC(=CC=3)C=3C=4CNC(=O)C=4C=CC=3)F)=CN(N=2)C(C)C)=C1 PLYYMDONYHTGKF-UHFFFAOYSA-N 0.000 claims 1
IIYCZIIWJDOJOQ-UHFFFAOYSA-N 1-[3-(3h-benzimidazol-5-yl)-1-propan-2-ylpyrazol-4-yl]-3-[2-fluoro-4-[2-(1h-pyrazol-4-yl)pyridin-4-yl]oxyphenyl]urea Chemical compound C=1C=C2NC=NC2=CC=1C1=NN(C(C)C)C=C1NC(=O)NC(C(=C1)F)=CC=C1OC(C=1)=CC=NC=1C=1C=NNC=1 IIYCZIIWJDOJOQ-UHFFFAOYSA-N 0.000 claims 1
SHZNCEOILTXZSZ-UHFFFAOYSA-N 1-[3-(3h-benzimidazol-5-yl)-1-propan-2-ylpyrazol-4-yl]-3-[2-fluoro-4-[2-(methanesulfonamido)pyridin-4-yl]oxyphenyl]urea Chemical compound C=1C=C2NC=NC2=CC=1C1=NN(C(C)C)C=C1NC(=O)NC(C(=C1)F)=CC=C1OC1=CC=NC(NS(C)(=O)=O)=C1 SHZNCEOILTXZSZ-UHFFFAOYSA-N 0.000 claims 1
NOOBTRAWBSESRB-UHFFFAOYSA-N 1-[3-(3h-benzimidazol-5-yl)-1-propan-2-ylpyrazol-4-yl]-3-[2-fluoro-4-[2-(propan-2-ylamino)pyridin-4-yl]oxyphenyl]urea Chemical compound C1=NC(NC(C)C)=CC(OC=2C=C(F)C(NC(=O)NC=3C(=NN(C=3)C(C)C)C=3C=C4N=CNC4=CC=3)=CC=2)=C1 NOOBTRAWBSESRB-UHFFFAOYSA-N 0.000 claims 1
ZADYFWDGWUPMMY-UHFFFAOYSA-N 1-[3-(3h-benzimidazol-5-yl)-1-propan-2-ylpyrazol-4-yl]-3-[4-(1-oxo-2,3-dihydroisoindol-4-yl)phenyl]urea Chemical compound C1=C2N=CNC2=CC(C=2C(NC(=O)NC=3C=CC(=CC=3)C=3C=4CNC(=O)C=4C=CC=3)=CN(N=2)C(C)C)=C1 ZADYFWDGWUPMMY-UHFFFAOYSA-N 0.000 claims 1
NWFKOUGPPBLMDZ-UHFFFAOYSA-N 1-[3-(3h-benzimidazol-5-yl)-1-propan-2-ylpyrazol-4-yl]-3-[4-[2-(1h-pyrazol-4-yl)pyridin-4-yl]oxyphenyl]urea Chemical compound C=1C=C2NC=NC2=CC=1C1=NN(C(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC(C=1)=CC=NC=1C=1C=NNC=1 NWFKOUGPPBLMDZ-UHFFFAOYSA-N 0.000 claims 1
LQZTZOSCLDTNKH-UHFFFAOYSA-N 1-[3-(3h-benzimidazol-5-yl)-1-tert-butylpyrazol-4-yl]-3-[2-fluoro-4-[2-(methanesulfonamido)pyridin-4-yl]oxyphenyl]urea Chemical compound C=1C=C2NC=NC2=CC=1C1=NN(C(C)(C)C)C=C1NC(=O)NC(C(=C1)F)=CC=C1OC1=CC=NC(NS(C)(=O)=O)=C1 LQZTZOSCLDTNKH-UHFFFAOYSA-N 0.000 claims 1
BOBRMFIDAUOJQU-UHFFFAOYSA-N 1-[3-(3h-benzimidazol-5-yl)-1-tert-butylpyrazol-4-yl]-3-[2-fluoro-4-[2-(propan-2-ylamino)pyridin-4-yl]oxyphenyl]urea Chemical compound C1=NC(NC(C)C)=CC(OC=2C=C(F)C(NC(=O)NC=3C(=NN(C=3)C(C)(C)C)C=3C=C4N=CNC4=CC=3)=CC=2)=C1 BOBRMFIDAUOJQU-UHFFFAOYSA-N 0.000 claims 1
RZYMXHLTUNQGLN-UHFFFAOYSA-N 1-[3-(3h-benzimidazol-5-yl)-1-tert-butylpyrazol-4-yl]-3-[4-(1-oxo-2,3-dihydroisoindol-4-yl)phenyl]urea Chemical compound C1=C2N=CNC2=CC(C=2C(NC(=O)NC=3C=CC(=CC=3)C=3C=4CNC(=O)C=4C=CC=3)=CN(N=2)C(C)(C)C)=C1 RZYMXHLTUNQGLN-UHFFFAOYSA-N 0.000 claims 1
CREKARXHLANGJV-UHFFFAOYSA-N 1-[3-(3h-benzimidazol-5-yl)-1-tert-butylpyrazol-4-yl]-3-[4-[2-(propan-2-ylamino)pyridin-4-yl]oxyphenyl]urea Chemical compound C1=NC(NC(C)C)=CC(OC=2C=CC(NC(=O)NC=3C(=NN(C=3)C(C)(C)C)C=3C=C4N=CNC4=CC=3)=CC=2)=C1 CREKARXHLANGJV-UHFFFAOYSA-N 0.000 claims 1
ZAYUFBQVLNEASV-UHFFFAOYSA-N 1-[3-(4-cyanophenyl)-1-propan-2-ylpyrazol-4-yl]-3-[4-[2-(1h-pyrazol-4-yl)pyridin-4-yl]oxyphenyl]urea Chemical compound C=1C=C(C#N)C=CC=1C1=NN(C(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC(C=1)=CC=NC=1C=1C=NNC=1 ZAYUFBQVLNEASV-UHFFFAOYSA-N 0.000 claims 1
SWAYHOUHIMJRKG-UHFFFAOYSA-N 1-[3-(4-fluorophenyl)-1-propan-2-ylpyrazol-4-yl]-3-[2-fluoro-4-[2-(1h-pyrazol-4-yl)pyridin-4-yl]oxyphenyl]urea Chemical compound C=1C=C(F)C=CC=1C1=NN(C(C)C)C=C1NC(=O)NC(C(=C1)F)=CC=C1OC(C=1)=CC=NC=1C=1C=NNC=1 SWAYHOUHIMJRKG-UHFFFAOYSA-N 0.000 claims 1
COZMPTOTUCUHTI-UHFFFAOYSA-N 1-[3-(6-cyanopyridin-3-yl)-1-propan-2-ylpyrazol-4-yl]-3-[2-fluoro-4-[2-(1h-pyrazol-4-yl)pyridin-4-yl]oxyphenyl]urea Chemical compound C=1C=C(C#N)N=CC=1C1=NN(C(C)C)C=C1NC(=O)NC(C(=C1)F)=CC=C1OC(C=1)=CC=NC=1C=1C=NNC=1 COZMPTOTUCUHTI-UHFFFAOYSA-N 0.000 claims 1
KCUUHIBRVSUJMU-UHFFFAOYSA-N 1-[3-(6-cyanopyridin-3-yl)-1-propan-2-ylpyrazol-4-yl]-3-[2-fluoro-4-methyl-5-[2-(methylamino)-7-oxo-8-propan-2-ylpyrido[2,3-d]pyrimidin-6-yl]phenyl]urea Chemical compound O=C1N(C(C)C)C2=NC(NC)=NC=C2C=C1C(C(=CC=1F)C)=CC=1NC(=O)NC1=CN(C(C)C)N=C1C1=CC=C(C#N)N=C1 KCUUHIBRVSUJMU-UHFFFAOYSA-N 0.000 claims 1
XQMTVVCAQVJLPM-UHFFFAOYSA-N 1-[3-(6-cyanopyridin-3-yl)-1-propan-2-ylpyrazol-4-yl]-3-[2-fluoro-5-[2-(methylamino)-7-oxo-8-propan-2-ylpyrido[2,3-d]pyrimidin-6-yl]phenyl]urea Chemical compound O=C1N(C(C)C)C2=NC(NC)=NC=C2C=C1C(C=1)=CC=C(F)C=1NC(=O)NC1=CN(C(C)C)N=C1C1=CC=C(C#N)N=C1 XQMTVVCAQVJLPM-UHFFFAOYSA-N 0.000 claims 1
WEGCWPCJADMXIN-UHFFFAOYSA-N 1-[3-(6-cyanopyridin-3-yl)-1-propan-2-ylpyrazol-4-yl]-3-[2-fluoro-5-[8-methyl-2-(methylamino)-7-oxopyrido[2,3-d]pyrimidin-6-yl]phenyl]urea Chemical compound O=C1N(C)C2=NC(NC)=NC=C2C=C1C(C=1)=CC=C(F)C=1NC(=O)NC1=CN(C(C)C)N=C1C1=CC=C(C#N)N=C1 WEGCWPCJADMXIN-UHFFFAOYSA-N 0.000 claims 1
IAKMHOYGOQRVGS-UHFFFAOYSA-N 1-[3-(6-cyanopyridin-3-yl)-1-propan-2-ylpyrazol-4-yl]-3-[4-[2-(1-methylpyrazol-4-yl)pyridin-4-yl]oxyphenyl]urea Chemical compound C=1C=C(C#N)N=CC=1C1=NN(C(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC(C=1)=CC=NC=1C=1C=NN(C)C=1 IAKMHOYGOQRVGS-UHFFFAOYSA-N 0.000 claims 1
HFZBEDJNTCOGJU-UHFFFAOYSA-N 1-[3-(6-cyanopyridin-3-yl)-1-propan-2-ylpyrazol-4-yl]-3-[4-[2-(1h-pyrazol-4-yl)pyridin-4-yl]oxyphenyl]urea Chemical compound C=1C=C(C#N)N=CC=1C1=NN(C(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC(C=1)=CC=NC=1C=1C=NNC=1 HFZBEDJNTCOGJU-UHFFFAOYSA-N 0.000 claims 1
LLEUREHSQQPRFX-UHFFFAOYSA-N 1-[4-(1,3-benzothiazol-5-yl)-2-tert-butylpyrimidin-5-yl]-3-[4-methyl-3-[8-methyl-2-(methylamino)-7-oxopyrido[2,3-d]pyrimidin-6-yl]phenyl]urea Chemical compound C1=C2SC=NC2=CC(C2=NC(=NC=C2NC(=O)NC=2C=C(C(=CC=2)C)C2=CC3=CN=C(N=C3N(C)C2=O)NC)C(C)(C)C)=C1 LLEUREHSQQPRFX-UHFFFAOYSA-N 0.000 claims 1
OTOKIIBNWNOEJU-UHFFFAOYSA-N 1-[4-(1,3-benzoxazol-5-yl)-2-tert-butylpyrimidin-5-yl]-3-[4-methyl-3-[8-methyl-2-(methylamino)-7-oxopyrido[2,3-d]pyrimidin-6-yl]phenyl]urea Chemical compound C1=C2OC=NC2=CC(C2=NC(=NC=C2NC(=O)NC=2C=C(C(=CC=2)C)C2=CC3=CN=C(N=C3N(C)C2=O)NC)C(C)(C)C)=C1 OTOKIIBNWNOEJU-UHFFFAOYSA-N 0.000 claims 1
UFGTUQOVBSECDE-UHFFFAOYSA-N 1-[4-(3-fluorophenyl)-2-propan-2-ylpyrimidin-5-yl]-3-[3-[8-methyl-2-(methylamino)-7-oxopyrido[2,3-d]pyrimidin-6-yl]phenyl]urea Chemical compound O=C1N(C)C2=NC(NC)=NC=C2C=C1C(C=1)=CC=CC=1NC(=O)NC1=CN=C(C(C)C)N=C1C1=CC=CC(F)=C1 UFGTUQOVBSECDE-UHFFFAOYSA-N 0.000 claims 1
ZXYBDGUHCKIRSU-UHFFFAOYSA-N 1-[4-[2-(1-methylpyrazol-4-yl)pyridin-4-yl]oxyphenyl]-3-(1-propan-2-yl-3-quinazolin-6-ylpyrazol-4-yl)urea Chemical compound C=1C=C2N=CN=CC2=CC=1C1=NN(C(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC(C=1)=CC=NC=1C=1C=NN(C)C=1 ZXYBDGUHCKIRSU-UHFFFAOYSA-N 0.000 claims 1
RQDARYIBTNWSRP-UHFFFAOYSA-N 1-[4-[2-(1-methylpyrazol-4-yl)pyridin-4-yl]oxyphenyl]-3-(1-propan-2-yl-3-quinolin-6-ylpyrazol-4-yl)urea Chemical compound C=1C=C2N=CC=CC2=CC=1C1=NN(C(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC(C=1)=CC=NC=1C=1C=NN(C)C=1 RQDARYIBTNWSRP-UHFFFAOYSA-N 0.000 claims 1
NPBJLMXPTRWLLD-UHFFFAOYSA-N 1-[4-[2-(1-methylpyrazol-4-yl)pyridin-4-yl]oxyphenyl]-3-[1-propan-2-yl-3-(1,2,3,4-tetrahydroisoquinolin-6-yl)pyrazol-4-yl]urea Chemical compound C=1C=C2CNCCC2=CC=1C1=NN(C(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC(C=1)=CC=NC=1C=1C=NN(C)C=1 NPBJLMXPTRWLLD-UHFFFAOYSA-N 0.000 claims 1
GYWDTSBIXINQFF-UHFFFAOYSA-N 1-[4-[2-(methanesulfonamido)pyridin-4-yl]oxyphenyl]-3-(5-propan-2-yl-2-quinazolin-6-ylpyrazol-3-yl)urea Chemical compound C=1C=C2N=CN=CC2=CC=1N1N=C(C(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC1=CC=NC(NS(C)(=O)=O)=C1 GYWDTSBIXINQFF-UHFFFAOYSA-N 0.000 claims 1
YRHHMSQYWPUYNQ-UHFFFAOYSA-N 1-[4-[2-(methanesulfonamido)pyridin-4-yl]oxyphenyl]-3-(5-propan-2-yl-2-quinolin-6-ylpyrazol-3-yl)urea Chemical compound C=1C=C2N=CC=CC2=CC=1N1N=C(C(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC1=CC=NC(NS(C)(=O)=O)=C1 YRHHMSQYWPUYNQ-UHFFFAOYSA-N 0.000 claims 1
CZAZYULIYDCZPB-UHFFFAOYSA-N 1-[4-[2-(methanesulfonamido)pyridin-4-yl]oxyphenyl]-3-[2-(2-methyl-3,4-dihydro-1h-isoquinolin-7-yl)-5-propan-2-ylpyrazol-3-yl]urea Chemical compound C=1C=C2CCN(C)CC2=CC=1N1N=C(C(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC1=CC=NC(NS(C)(=O)=O)=C1 CZAZYULIYDCZPB-UHFFFAOYSA-N 0.000 claims 1
AKQQGTOEAMUMHC-UHFFFAOYSA-N 1-[4-[2-(methanesulfonamido)pyridin-4-yl]oxyphenyl]-3-[3-(2-methyl-3,4-dihydro-1h-isoquinolin-6-yl)-1-propan-2-ylpyrazol-4-yl]urea Chemical compound C=1C=C2CN(C)CCC2=CC=1C1=NN(C(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC1=CC=NC(NS(C)(=O)=O)=C1 AKQQGTOEAMUMHC-UHFFFAOYSA-N 0.000 claims 1
HPCCAIAAXCAYBG-UHFFFAOYSA-N 1-[4-[2-(methanesulfonamido)pyridin-4-yl]oxyphenyl]-3-[5-propan-2-yl-2-(1,2,3,4-tetrahydroisoquinolin-6-yl)pyrazol-3-yl]urea Chemical compound C=1C=C2CNCCC2=CC=1N1N=C(C(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC1=CC=NC(NS(C)(=O)=O)=C1 HPCCAIAAXCAYBG-UHFFFAOYSA-N 0.000 claims 1
KHEBIOUYPUVBBM-UHFFFAOYSA-N 1-[4-[2-(propan-2-ylamino)pyridin-4-yl]oxyphenyl]-3-(1-propan-2-yl-3-quinazolin-6-ylpyrazol-4-yl)urea Chemical compound C1=NC(NC(C)C)=CC(OC=2C=CC(NC(=O)NC=3C(=NN(C=3)C(C)C)C=3C=C4C=NC=NC4=CC=3)=CC=2)=C1 KHEBIOUYPUVBBM-UHFFFAOYSA-N 0.000 claims 1
UQJYRMXCFAIPJX-UHFFFAOYSA-N 1-[4-[2-(propan-2-ylamino)pyridin-4-yl]oxyphenyl]-3-(1-propan-2-yl-3-quinolin-6-ylpyrazol-4-yl)urea Chemical compound C1=NC(NC(C)C)=CC(OC=2C=CC(NC(=O)NC=3C(=NN(C=3)C(C)C)C=3C=C4C=CC=NC4=CC=3)=CC=2)=C1 UQJYRMXCFAIPJX-UHFFFAOYSA-N 0.000 claims 1
QWHANNQZANPYQD-UHFFFAOYSA-N 1-[4-[2-(propan-2-ylamino)pyridin-4-yl]oxyphenyl]-3-(5-propan-2-yl-2-quinazolin-6-ylpyrazol-3-yl)urea Chemical compound C1=NC(NC(C)C)=CC(OC=2C=CC(NC(=O)NC=3N(N=C(C=3)C(C)C)C=3C=C4C=NC=NC4=CC=3)=CC=2)=C1 QWHANNQZANPYQD-UHFFFAOYSA-N 0.000 claims 1
HANIRJDEXBHZIR-UHFFFAOYSA-N 1-[5-[8-cyclopentyl-2-(methylamino)-7-oxopyrido[2,3-d]pyrimidin-6-yl]-2-fluorophenyl]-3-(2-phenyl-5-propan-2-ylpyrazol-3-yl)urea Chemical compound O=C1N(C2CCCC2)C2=NC(NC)=NC=C2C=C1C(C=1)=CC=C(F)C=1NC(=O)NC1=CC(C(C)C)=NN1C1=CC=CC=C1 HANIRJDEXBHZIR-UHFFFAOYSA-N 0.000 claims 1
UTTXGNIRWZNGDP-UHFFFAOYSA-N 1-[5-[8-cyclopentyl-2-(methylamino)-7-oxopyrido[2,3-d]pyrimidin-6-yl]-2-fluorophenyl]-3-(5-propan-2-yl-2-pyridin-3-ylpyrazol-3-yl)urea Chemical compound O=C1N(C2CCCC2)C2=NC(NC)=NC=C2C=C1C(C=1)=CC=C(F)C=1NC(=O)NC1=CC(C(C)C)=NN1C1=CC=CN=C1 UTTXGNIRWZNGDP-UHFFFAOYSA-N 0.000 claims 1
JGSCVTSFYBUCHL-UHFFFAOYSA-N 1-[5-[8-cyclopentyl-2-(methylamino)-7-oxopyrido[2,3-d]pyrimidin-6-yl]-2-fluorophenyl]-3-[2-(3-fluorophenyl)-5-propan-2-ylpyrazol-3-yl]urea Chemical compound O=C1N(C2CCCC2)C2=NC(NC)=NC=C2C=C1C(C=1)=CC=C(F)C=1NC(=O)NC1=CC(C(C)C)=NN1C1=CC=CC(F)=C1 JGSCVTSFYBUCHL-UHFFFAOYSA-N 0.000 claims 1
OSBBACPIVSEWJE-UHFFFAOYSA-N 1-[5-[8-cyclopentyl-2-(methylamino)-7-oxopyrido[2,3-d]pyrimidin-6-yl]-2-fluorophenyl]-3-[2-(4-fluorophenyl)-5-propan-2-ylpyrazol-3-yl]urea Chemical compound O=C1N(C2CCCC2)C2=NC(NC)=NC=C2C=C1C(C=1)=CC=C(F)C=1NC(=O)NC1=CC(C(C)C)=NN1C1=CC=C(F)C=C1 OSBBACPIVSEWJE-UHFFFAOYSA-N 0.000 claims 1
XFYPYRPBIPUTET-UHFFFAOYSA-N 1-[5-tert-butyl-2-(1,2,3,4-tetrahydroisoquinolin-6-yl)pyrazol-3-yl]-3-(2,3-dichlorophenyl)urea Chemical compound C=1C=C2CNCCC2=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)NC1=CC=CC(Cl)=C1Cl XFYPYRPBIPUTET-UHFFFAOYSA-N 0.000 claims 1
RHTPETKTBBFGJY-UHFFFAOYSA-N 1-[5-tert-butyl-2-(1,2,3,4-tetrahydroisoquinolin-6-yl)pyrazol-3-yl]-3-[2-fluoro-4-[2-(1h-pyrazol-4-yl)pyridin-4-yl]oxyphenyl]urea Chemical compound C=1C=C2CNCCC2=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)NC(C(=C1)F)=CC=C1OC(C=1)=CC=NC=1C=1C=NNC=1 RHTPETKTBBFGJY-UHFFFAOYSA-N 0.000 claims 1
HFFHEYKMHQDRRJ-UHFFFAOYSA-N 1-[5-tert-butyl-2-(1,2,3,4-tetrahydroisoquinolin-6-yl)pyrazol-3-yl]-3-[2-fluoro-5-(1-oxo-2,3-dihydroisoindol-4-yl)phenyl]urea Chemical compound C1NCCC2=CC(N3C(NC(=O)NC=4C(=CC=C(C=4)C=4C=5CNC(=O)C=5C=CC=4)F)=CC(=N3)C(C)(C)C)=CC=C21 HFFHEYKMHQDRRJ-UHFFFAOYSA-N 0.000 claims 1
WNIWXMGVSPDDEQ-UHFFFAOYSA-N 1-[5-tert-butyl-2-(1,2,3,4-tetrahydroisoquinolin-6-yl)pyrazol-3-yl]-3-[3-(1-oxo-2,3-dihydroisoindol-4-yl)phenyl]urea Chemical compound C1NCCC2=CC(N3C(NC(=O)NC=4C=C(C=CC=4)C=4C=5CNC(=O)C=5C=CC=4)=CC(=N3)C(C)(C)C)=CC=C21 WNIWXMGVSPDDEQ-UHFFFAOYSA-N 0.000 claims 1
OPADNEULIKBWLH-UHFFFAOYSA-N 1-[5-tert-butyl-2-(1,2,3,4-tetrahydroisoquinolin-6-yl)pyrazol-3-yl]-3-[4-(1-oxo-2,3-dihydroisoindol-4-yl)phenyl]urea Chemical compound C1NCCC2=CC(N3C(NC(=O)NC=4C=CC(=CC=4)C=4C=5CNC(=O)C=5C=CC=4)=CC(=N3)C(C)(C)C)=CC=C21 OPADNEULIKBWLH-UHFFFAOYSA-N 0.000 claims 1
MHDOJZNLRBLQTE-UHFFFAOYSA-N 1-[5-tert-butyl-2-(1,2,3,4-tetrahydroisoquinolin-6-yl)pyrazol-3-yl]-3-[4-[2-(methanesulfonamido)pyridin-4-yl]oxyphenyl]urea Chemical compound C=1C=C2CNCCC2=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC1=CC=NC(NS(C)(=O)=O)=C1 MHDOJZNLRBLQTE-UHFFFAOYSA-N 0.000 claims 1
FVXFHIGKYNZGSY-UHFFFAOYSA-N 1-[5-tert-butyl-2-(1,2,3,4-tetrahydroisoquinolin-6-yl)pyrazol-3-yl]-3-[4-[2-(propan-2-ylamino)pyridin-4-yl]oxyphenyl]urea Chemical compound C1=NC(NC(C)C)=CC(OC=2C=CC(NC(=O)NC=3N(N=C(C=3)C(C)(C)C)C=3C=C4CCNCC4=CC=3)=CC=2)=C1 FVXFHIGKYNZGSY-UHFFFAOYSA-N 0.000 claims 1
FYGRTSKUSQFFNM-UHFFFAOYSA-N 1-[5-tert-butyl-2-(1,2,3,4-tetrahydroisoquinolin-7-yl)pyrazol-3-yl]-3-[2-fluoro-4-(1-oxo-2,3-dihydroisoindol-4-yl)phenyl]urea Chemical compound C1CNCC2=CC(N3C(NC(=O)NC=4C(=CC(=CC=4)C=4C=5CNC(=O)C=5C=CC=4)F)=CC(=N3)C(C)(C)C)=CC=C21 FYGRTSKUSQFFNM-UHFFFAOYSA-N 0.000 claims 1
DINSZQDCZRMVMI-UHFFFAOYSA-N 1-[5-tert-butyl-2-(1,2,3,4-tetrahydroisoquinolin-7-yl)pyrazol-3-yl]-3-[2-fluoro-5-(1-oxo-2,3-dihydroisoindol-4-yl)phenyl]urea Chemical compound C1CNCC2=CC(N3C(NC(=O)NC=4C(=CC=C(C=4)C=4C=5CNC(=O)C=5C=CC=4)F)=CC(=N3)C(C)(C)C)=CC=C21 DINSZQDCZRMVMI-UHFFFAOYSA-N 0.000 claims 1
SVNSZHWFYMNEFZ-UHFFFAOYSA-N 1-[5-tert-butyl-2-(1,2,3,4-tetrahydroisoquinolin-7-yl)pyrazol-3-yl]-3-[4-(1-oxo-2,3-dihydroisoindol-4-yl)phenyl]urea Chemical compound C1CNCC2=CC(N3C(NC(=O)NC=4C=CC(=CC=4)C=4C=5CNC(=O)C=5C=CC=4)=CC(=N3)C(C)(C)C)=CC=C21 SVNSZHWFYMNEFZ-UHFFFAOYSA-N 0.000 claims 1
XERUVMGMRQHISW-UHFFFAOYSA-N 1-[5-tert-butyl-2-(1,2-oxazol-4-yl)pyrazol-3-yl]-3-[2-fluoro-5-[2-(methylamino)-7-oxo-8-propan-2-ylpyrido[2,3-d]pyrimidin-6-yl]phenyl]urea Chemical compound O=C1N(C(C)C)C2=NC(NC)=NC=C2C=C1C(C=1)=CC=C(F)C=1NC(=O)NC1=CC(C(C)(C)C)=NN1C=1C=NOC=1 XERUVMGMRQHISW-UHFFFAOYSA-N 0.000 claims 1
SCLGGQRUADJAFA-UHFFFAOYSA-N 1-[5-tert-butyl-2-(1,2-thiazol-4-yl)pyrazol-3-yl]-3-[2-fluoro-5-[2-(methylamino)-7-oxo-8-propan-2-ylpyrido[2,3-d]pyrimidin-6-yl]phenyl]urea Chemical compound O=C1N(C(C)C)C2=NC(NC)=NC=C2C=C1C(C=1)=CC=C(F)C=1NC(=O)NC1=CC(C(C)(C)C)=NN1C=1C=NSC=1 SCLGGQRUADJAFA-UHFFFAOYSA-N 0.000 claims 1
VDPFADJXJOKIQJ-UHFFFAOYSA-N 1-[5-tert-butyl-2-(1,2-thiazol-4-yl)pyrazol-3-yl]-3-[3-[2-(methylamino)-7-oxo-8-propan-2-ylpyrido[2,3-d]pyrimidin-6-yl]phenyl]urea Chemical compound O=C1N(C(C)C)C2=NC(NC)=NC=C2C=C1C(C=1)=CC=CC=1NC(=O)NC1=CC(C(C)(C)C)=NN1C=1C=NSC=1 VDPFADJXJOKIQJ-UHFFFAOYSA-N 0.000 claims 1
MQXBTPFHHOAZBR-UHFFFAOYSA-N 1-[5-tert-butyl-2-(1,3-thiazol-5-yl)pyrazol-3-yl]-3-[3-[2-(methylamino)-7-oxo-8-propan-2-ylpyrido[2,3-d]pyrimidin-6-yl]phenyl]urea Chemical compound O=C1N(C(C)C)C2=NC(NC)=NC=C2C=C1C(C=1)=CC=CC=1NC(=O)NC1=CC(C(C)(C)C)=NN1C1=CN=CS1 MQXBTPFHHOAZBR-UHFFFAOYSA-N 0.000 claims 1
HLJRXVGMSTYGIO-UHFFFAOYSA-N 1-[5-tert-butyl-2-(1h-indazol-5-yl)pyrazol-3-yl]-3-[2-fluoro-4-(1-oxo-2,3-dihydroisoindol-4-yl)phenyl]urea Chemical compound C1=C2NN=CC2=CC(N2C(NC(=O)NC=3C(=CC(=CC=3)C=3C=4CNC(=O)C=4C=CC=3)F)=CC(=N2)C(C)(C)C)=C1 HLJRXVGMSTYGIO-UHFFFAOYSA-N 0.000 claims 1
STIBSYWDMULTPX-UHFFFAOYSA-N 1-[5-tert-butyl-2-(1h-indazol-5-yl)pyrazol-3-yl]-3-[2-fluoro-4-[2-(1h-pyrazol-4-yl)pyridin-4-yl]oxyphenyl]urea Chemical compound C=1C=C2NN=CC2=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)NC(C(=C1)F)=CC=C1OC(C=1)=CC=NC=1C=1C=NNC=1 STIBSYWDMULTPX-UHFFFAOYSA-N 0.000 claims 1
UPCPIFZUQCTWOT-UHFFFAOYSA-N 1-[5-tert-butyl-2-(1h-indazol-5-yl)pyrazol-3-yl]-3-[2-fluoro-4-[2-(methanesulfonamido)pyridin-4-yl]oxyphenyl]urea Chemical compound C=1C=C2NN=CC2=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)NC(C(=C1)F)=CC=C1OC1=CC=NC(NS(C)(=O)=O)=C1 UPCPIFZUQCTWOT-UHFFFAOYSA-N 0.000 claims 1
ANYVBRMERIDLJI-UHFFFAOYSA-N 1-[5-tert-butyl-2-(1h-indazol-5-yl)pyrazol-3-yl]-3-[2-fluoro-4-[2-(propan-2-ylamino)pyridin-4-yl]oxyphenyl]urea Chemical compound C1=NC(NC(C)C)=CC(OC=2C=C(F)C(NC(=O)NC=3N(N=C(C=3)C(C)(C)C)C=3C=C4C=NNC4=CC=3)=CC=2)=C1 ANYVBRMERIDLJI-UHFFFAOYSA-N 0.000 claims 1
JVIXOTOKQMVDSW-UHFFFAOYSA-N 1-[5-tert-butyl-2-(1h-indazol-5-yl)pyrazol-3-yl]-3-[2-fluoro-5-(1-oxo-2,3-dihydroisoindol-4-yl)phenyl]urea Chemical compound C1=C2NN=CC2=CC(N2C(NC(=O)NC=3C(=CC=C(C=3)C=3C=4CNC(=O)C=4C=CC=3)F)=CC(=N2)C(C)(C)C)=C1 JVIXOTOKQMVDSW-UHFFFAOYSA-N 0.000 claims 1
LLDNPVMUYKJGLF-UHFFFAOYSA-N 1-[5-tert-butyl-2-(1h-indazol-5-yl)pyrazol-3-yl]-3-[4-[2-(1h-pyrazol-4-yl)pyridin-4-yl]oxyphenyl]urea Chemical compound C=1C=C2NN=CC2=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC(C=1)=CC=NC=1C=1C=NNC=1 LLDNPVMUYKJGLF-UHFFFAOYSA-N 0.000 claims 1
JSGIFAXAVYCPNO-UHFFFAOYSA-N 1-[5-tert-butyl-2-(1h-indazol-5-yl)pyrazol-3-yl]-3-[4-[2-(propan-2-ylamino)pyridin-4-yl]oxyphenyl]urea Chemical compound C1=NC(NC(C)C)=CC(OC=2C=CC(NC(=O)NC=3N(N=C(C=3)C(C)(C)C)C=3C=C4C=NNC4=CC=3)=CC=2)=C1 JSGIFAXAVYCPNO-UHFFFAOYSA-N 0.000 claims 1
BHTQTGCPNFRJBV-UHFFFAOYSA-N 1-[5-tert-butyl-2-(1h-indazol-5-yl)pyrazol-3-yl]-3-[4-methyl-3-[8-methyl-2-(methylamino)-7-oxopyrido[2,3-d]pyrimidin-6-yl]phenyl]urea Chemical compound C1=C2NN=CC2=CC(N2N=C(C=C2NC(=O)NC=2C=C(C(=CC=2)C)C2=CC3=CN=C(N=C3N(C)C2=O)NC)C(C)(C)C)=C1 BHTQTGCPNFRJBV-UHFFFAOYSA-N 0.000 claims 1
NIQORGWMYICECG-UHFFFAOYSA-N 1-[5-tert-butyl-2-(1h-pyrazol-4-yl)pyrazol-3-yl]-3-[2-fluoro-5-[2-(methylamino)-7-oxo-8-propan-2-ylpyrido[2,3-d]pyrimidin-6-yl]phenyl]urea Chemical compound O=C1N(C(C)C)C2=NC(NC)=NC=C2C=C1C(C=1)=CC=C(F)C=1NC(=O)NC1=CC(C(C)(C)C)=NN1C=1C=NNC=1 NIQORGWMYICECG-UHFFFAOYSA-N 0.000 claims 1
PXWADYACOGTXBP-UHFFFAOYSA-N 1-[5-tert-butyl-2-(1h-pyrazol-4-yl)pyrazol-3-yl]-3-[3-[2-(methylamino)-7-oxo-8-propan-2-ylpyrido[2,3-d]pyrimidin-6-yl]phenyl]urea Chemical compound O=C1N(C(C)C)C2=NC(NC)=NC=C2C=C1C(C=1)=CC=CC=1NC(=O)NC1=CC(C(C)(C)C)=NN1C=1C=NNC=1 PXWADYACOGTXBP-UHFFFAOYSA-N 0.000 claims 1
SQUXHMFIIIUZBC-UHFFFAOYSA-N 1-[5-tert-butyl-2-(2-methyl-3,4-dihydro-1h-isoquinolin-6-yl)pyrazol-3-yl]-3-(2,3-dichlorophenyl)urea Chemical compound C=1C=C2CN(C)CCC2=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)NC1=CC=CC(Cl)=C1Cl SQUXHMFIIIUZBC-UHFFFAOYSA-N 0.000 claims 1
INVVODJJTODLBK-UHFFFAOYSA-N 1-[5-tert-butyl-2-(2-methyl-3,4-dihydro-1h-isoquinolin-6-yl)pyrazol-3-yl]-3-[2-fluoro-4-[2-(1h-pyrazol-4-yl)pyridin-4-yl]oxyphenyl]urea Chemical compound C=1C=C2CN(C)CCC2=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)NC(C(=C1)F)=CC=C1OC(C=1)=CC=NC=1C=1C=NNC=1 INVVODJJTODLBK-UHFFFAOYSA-N 0.000 claims 1
HANMGRJXBPZPGB-UHFFFAOYSA-N 1-[5-tert-butyl-2-(2-methyl-3,4-dihydro-1h-isoquinolin-6-yl)pyrazol-3-yl]-3-[2-fluoro-4-[2-(methanesulfonamido)pyridin-4-yl]oxyphenyl]urea Chemical compound C=1C=C2CN(C)CCC2=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)NC(C(=C1)F)=CC=C1OC1=CC=NC(NS(C)(=O)=O)=C1 HANMGRJXBPZPGB-UHFFFAOYSA-N 0.000 claims 1
GFWCUMGCGYNGFJ-UHFFFAOYSA-N 1-[5-tert-butyl-2-(2-methyl-3,4-dihydro-1h-isoquinolin-6-yl)pyrazol-3-yl]-3-[2-fluoro-5-(1-oxo-2,3-dihydroisoindol-4-yl)phenyl]urea Chemical compound C=1C=C2CN(C)CCC2=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)NC(C(=CC=1)F)=CC=1C1=CC=CC2=C1CNC2=O GFWCUMGCGYNGFJ-UHFFFAOYSA-N 0.000 claims 1
TVZDVUAWDLOYEH-UHFFFAOYSA-N 1-[5-tert-butyl-2-(2-methyl-3,4-dihydro-1h-isoquinolin-6-yl)pyrazol-3-yl]-3-[3-(1-oxo-2,3-dihydroisoindol-4-yl)phenyl]urea Chemical compound C=1C=C2CN(C)CCC2=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)NC(C=1)=CC=CC=1C1=CC=CC2=C1CNC2=O TVZDVUAWDLOYEH-UHFFFAOYSA-N 0.000 claims 1
CEKYTUHNZXASSK-UHFFFAOYSA-N 1-[5-tert-butyl-2-(2-methyl-3,4-dihydro-1h-isoquinolin-6-yl)pyrazol-3-yl]-3-[4-(1-oxo-2,3-dihydroisoindol-4-yl)phenyl]urea Chemical compound C=1C=C2CN(C)CCC2=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)NC(C=C1)=CC=C1C1=CC=CC2=C1CNC2=O CEKYTUHNZXASSK-UHFFFAOYSA-N 0.000 claims 1
XMYNHBYBCQJWHI-UHFFFAOYSA-N 1-[5-tert-butyl-2-(2-methyl-3,4-dihydro-1h-isoquinolin-6-yl)pyrazol-3-yl]-3-[4-[2-(1h-pyrazol-4-yl)pyridin-4-yl]oxyphenyl]urea Chemical compound C=1C=C2CN(C)CCC2=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC(C=1)=CC=NC=1C=1C=NNC=1 XMYNHBYBCQJWHI-UHFFFAOYSA-N 0.000 claims 1
OEXVROHRZLQXND-UHFFFAOYSA-N 1-[5-tert-butyl-2-(2-methyl-3,4-dihydro-1h-isoquinolin-6-yl)pyrazol-3-yl]-3-[4-[2-(propan-2-ylamino)pyridin-4-yl]oxyphenyl]urea Chemical compound C1=NC(NC(C)C)=CC(OC=2C=CC(NC(=O)NC=3N(N=C(C=3)C(C)(C)C)C=3C=C4CCN(C)CC4=CC=3)=CC=2)=C1 OEXVROHRZLQXND-UHFFFAOYSA-N 0.000 claims 1
BKRVDAXGNFSVKR-UHFFFAOYSA-N 1-[5-tert-butyl-2-(2-methyl-3,4-dihydro-1h-isoquinolin-7-yl)pyrazol-3-yl]-3-[2-fluoro-4-[2-(1h-pyrazol-4-yl)pyridin-4-yl]oxyphenyl]urea Chemical compound C1=C2CN(C)CCC2=CC=C1N1N=C(C(C)(C)C)C=C1NC(=O)NC(C(=C1)F)=CC=C1OC(C=1)=CC=NC=1C=1C=NNC=1 BKRVDAXGNFSVKR-UHFFFAOYSA-N 0.000 claims 1
ABLVPJFZHPCQQY-UHFFFAOYSA-N 1-[5-tert-butyl-2-(2-methyl-3,4-dihydro-1h-isoquinolin-7-yl)pyrazol-3-yl]-3-[2-fluoro-5-(1-oxo-2,3-dihydroisoindol-4-yl)phenyl]urea Chemical compound C1=C2CN(C)CCC2=CC=C1N1N=C(C(C)(C)C)C=C1NC(=O)NC(C(=CC=1)F)=CC=1C1=CC=CC2=C1CNC2=O ABLVPJFZHPCQQY-UHFFFAOYSA-N 0.000 claims 1
XHYOAZATOXMQFD-UHFFFAOYSA-N 1-[5-tert-butyl-2-(2-methyl-3,4-dihydro-1h-isoquinolin-7-yl)pyrazol-3-yl]-3-[4-(1-oxo-2,3-dihydroisoindol-4-yl)phenyl]urea Chemical compound C1=C2CN(C)CCC2=CC=C1N1N=C(C(C)(C)C)C=C1NC(=O)NC(C=C1)=CC=C1C1=CC=CC2=C1CNC2=O XHYOAZATOXMQFD-UHFFFAOYSA-N 0.000 claims 1
GXOSBVDCLCGYMS-UHFFFAOYSA-N 1-[5-tert-butyl-2-(3-cyanophenyl)pyrazol-3-yl]-3-[2-fluoro-4-(1-oxo-2,3-dihydroisoindol-4-yl)phenyl]urea Chemical compound N1=C(C(C)(C)C)C=C(NC(=O)NC=2C(=CC(=CC=2)C=2C=3CNC(=O)C=3C=CC=2)F)N1C1=CC=CC(C#N)=C1 GXOSBVDCLCGYMS-UHFFFAOYSA-N 0.000 claims 1
HDOWRPVPQUZRBH-UHFFFAOYSA-N 1-[5-tert-butyl-2-(3-cyanophenyl)pyrazol-3-yl]-3-[2-fluoro-4-[2-(1-methylpyrazol-4-yl)pyridin-4-yl]oxyphenyl]urea Chemical compound C1=NN(C)C=C1C1=CC(OC=2C=C(F)C(NC(=O)NC=3N(N=C(C=3)C(C)(C)C)C=3C=C(C=CC=3)C#N)=CC=2)=CC=N1 HDOWRPVPQUZRBH-UHFFFAOYSA-N 0.000 claims 1
BJSHVIONEMTMIQ-UHFFFAOYSA-N 1-[5-tert-butyl-2-(3-cyanophenyl)pyrazol-3-yl]-3-[2-fluoro-4-[2-(1h-pyrazol-4-yl)pyridin-4-yl]oxyphenyl]urea Chemical compound C=1C=CC(C#N)=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)NC(C(=C1)F)=CC=C1OC(C=1)=CC=NC=1C=1C=NNC=1 BJSHVIONEMTMIQ-UHFFFAOYSA-N 0.000 claims 1
UYZRWAIKAKVZNQ-UHFFFAOYSA-N 1-[5-tert-butyl-2-(3-cyanophenyl)pyrazol-3-yl]-3-[2-fluoro-4-methyl-5-[2-(methylamino)-7-oxo-8-propan-2-ylpyrido[2,3-d]pyrimidin-6-yl]phenyl]urea Chemical compound O=C1N(C(C)C)C2=NC(NC)=NC=C2C=C1C(C(=CC=1F)C)=CC=1NC(=O)NC1=CC(C(C)(C)C)=NN1C1=CC=CC(C#N)=C1 UYZRWAIKAKVZNQ-UHFFFAOYSA-N 0.000 claims 1
FKWMXIRDWBDLOT-UHFFFAOYSA-N 1-[5-tert-butyl-2-(3-cyanophenyl)pyrazol-3-yl]-3-[2-fluoro-5-[2-(methylamino)-7-oxo-8-propan-2-ylpyrido[2,3-d]pyrimidin-6-yl]phenyl]urea Chemical compound O=C1N(C(C)C)C2=NC(NC)=NC=C2C=C1C(C=1)=CC=C(F)C=1NC(=O)NC1=CC(C(C)(C)C)=NN1C1=CC=CC(C#N)=C1 FKWMXIRDWBDLOT-UHFFFAOYSA-N 0.000 claims 1
WIXHDUHUBGGJOV-UHFFFAOYSA-N 1-[5-tert-butyl-2-(3-cyanophenyl)pyrazol-3-yl]-3-[2-fluoro-5-[8-methyl-2-(methylamino)-7-oxopyrido[2,3-d]pyrimidin-6-yl]phenyl]urea Chemical compound O=C1N(C)C2=NC(NC)=NC=C2C=C1C(C=1)=CC=C(F)C=1NC(=O)NC1=CC(C(C)(C)C)=NN1C1=CC=CC(C#N)=C1 WIXHDUHUBGGJOV-UHFFFAOYSA-N 0.000 claims 1
ZXRJKCYDMDQYGF-UHFFFAOYSA-N 1-[5-tert-butyl-2-(3-cyanophenyl)pyrazol-3-yl]-3-[3-[2-(methylamino)-7-oxo-8-propan-2-ylpyrido[2,3-d]pyrimidin-6-yl]phenyl]urea Chemical compound O=C1N(C(C)C)C2=NC(NC)=NC=C2C=C1C(C=1)=CC=CC=1NC(=O)NC1=CC(C(C)(C)C)=NN1C1=CC=CC(C#N)=C1 ZXRJKCYDMDQYGF-UHFFFAOYSA-N 0.000 claims 1
VUSXDVZWMYKKHM-UHFFFAOYSA-N 1-[5-tert-butyl-2-(3-cyanophenyl)pyrazol-3-yl]-3-[3-[8-(1-hydroxy-2-methylpropan-2-yl)-2-(methylamino)-7-oxopyrido[2,3-d]pyrimidin-6-yl]phenyl]urea Chemical compound O=C1N(C(C)(C)CO)C2=NC(NC)=NC=C2C=C1C(C=1)=CC=CC=1NC(=O)NC1=CC(C(C)(C)C)=NN1C1=CC=CC(C#N)=C1 VUSXDVZWMYKKHM-UHFFFAOYSA-N 0.000 claims 1
CGOPYWXDPWXNGA-UHFFFAOYSA-N 1-[5-tert-butyl-2-(3-cyanophenyl)pyrazol-3-yl]-3-[4-(1-oxo-2,3-dihydroisoindol-4-yl)phenyl]urea Chemical compound N1=C(C(C)(C)C)C=C(NC(=O)NC=2C=CC(=CC=2)C=2C=3CNC(=O)C=3C=CC=2)N1C1=CC=CC(C#N)=C1 CGOPYWXDPWXNGA-UHFFFAOYSA-N 0.000 claims 1
RDMDGTKOSUIUJA-UHFFFAOYSA-N 1-[5-tert-butyl-2-(3-cyanophenyl)pyrazol-3-yl]-3-[4-[2-(1-methylpyrazol-4-yl)pyridin-4-yl]oxyphenyl]urea Chemical compound C1=NN(C)C=C1C1=CC(OC=2C=CC(NC(=O)NC=3N(N=C(C=3)C(C)(C)C)C=3C=C(C=CC=3)C#N)=CC=2)=CC=N1 RDMDGTKOSUIUJA-UHFFFAOYSA-N 0.000 claims 1
ZTEZHWNVQKSGBD-UHFFFAOYSA-N 1-[5-tert-butyl-2-(3-cyanophenyl)pyrazol-3-yl]-3-[4-[2-(1h-pyrazol-4-yl)pyridin-4-yl]oxyphenyl]urea Chemical compound C=1C=CC(C#N)=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC(C=1)=CC=NC=1C=1C=NNC=1 ZTEZHWNVQKSGBD-UHFFFAOYSA-N 0.000 claims 1
LWUUXUXJKFHPRW-UHFFFAOYSA-N 1-[5-tert-butyl-2-(3-fluorophenyl)pyrazol-3-yl]-3-[2-fluoro-4-(1-oxo-2,3-dihydroisoindol-4-yl)phenyl]urea Chemical compound N1=C(C(C)(C)C)C=C(NC(=O)NC=2C(=CC(=CC=2)C=2C=3CNC(=O)C=3C=CC=2)F)N1C1=CC=CC(F)=C1 LWUUXUXJKFHPRW-UHFFFAOYSA-N 0.000 claims 1
DRYUOTSDFMLKHB-UHFFFAOYSA-N 1-[5-tert-butyl-2-(3-fluorophenyl)pyrazol-3-yl]-3-[2-fluoro-4-[2-(1h-pyrazol-4-yl)pyridin-4-yl]oxyphenyl]urea Chemical compound C=1C=CC(F)=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)NC(C(=C1)F)=CC=C1OC(C=1)=CC=NC=1C=1C=NNC=1 DRYUOTSDFMLKHB-UHFFFAOYSA-N 0.000 claims 1
MVOYOCLJKTXIDM-UHFFFAOYSA-N 1-[5-tert-butyl-2-(3-fluorophenyl)pyrazol-3-yl]-3-[2-fluoro-4-methyl-5-[2-(methylamino)-7-oxo-8-propan-2-ylpyrido[2,3-d]pyrimidin-6-yl]phenyl]urea Chemical compound O=C1N(C(C)C)C2=NC(NC)=NC=C2C=C1C(C(=CC=1F)C)=CC=1NC(=O)NC1=CC(C(C)(C)C)=NN1C1=CC=CC(F)=C1 MVOYOCLJKTXIDM-UHFFFAOYSA-N 0.000 claims 1
SVQMWUZVLYEILS-UHFFFAOYSA-N 1-[5-tert-butyl-2-(3-fluorophenyl)pyrazol-3-yl]-3-[2-fluoro-5-(1-oxo-2,3-dihydroisoindol-4-yl)phenyl]urea Chemical compound N1=C(C(C)(C)C)C=C(NC(=O)NC=2C(=CC=C(C=2)C=2C=3CNC(=O)C=3C=CC=2)F)N1C1=CC=CC(F)=C1 SVQMWUZVLYEILS-UHFFFAOYSA-N 0.000 claims 1
CHTHEZJPTIENHY-UHFFFAOYSA-N 1-[5-tert-butyl-2-(3-fluorophenyl)pyrazol-3-yl]-3-[2-fluoro-5-[2-(methylamino)-7-oxo-8-propan-2-ylpyrido[2,3-d]pyrimidin-6-yl]phenyl]urea Chemical compound O=C1N(C(C)C)C2=NC(NC)=NC=C2C=C1C(C=1)=CC=C(F)C=1NC(=O)NC1=CC(C(C)(C)C)=NN1C1=CC=CC(F)=C1 CHTHEZJPTIENHY-UHFFFAOYSA-N 0.000 claims 1
XJSPQCUQZNBIKI-UHFFFAOYSA-N 1-[5-tert-butyl-2-(3-fluorophenyl)pyrazol-3-yl]-3-[3-(1-oxo-2,3-dihydroisoindol-4-yl)phenyl]urea Chemical compound N1=C(C(C)(C)C)C=C(NC(=O)NC=2C=C(C=CC=2)C=2C=3CNC(=O)C=3C=CC=2)N1C1=CC=CC(F)=C1 XJSPQCUQZNBIKI-UHFFFAOYSA-N 0.000 claims 1
ACJKFTLMSSDZHH-UHFFFAOYSA-N 1-[5-tert-butyl-2-(3-fluorophenyl)pyrazol-3-yl]-3-[3-[8-cyclopentyl-2-(methylamino)-7-oxopyrido[2,3-d]pyrimidin-6-yl]phenyl]urea Chemical compound O=C1N(C2CCCC2)C2=NC(NC)=NC=C2C=C1C(C=1)=CC=CC=1NC(=O)NC1=CC(C(C)(C)C)=NN1C1=CC=CC(F)=C1 ACJKFTLMSSDZHH-UHFFFAOYSA-N 0.000 claims 1
LDJUQOAFQIOHDX-UHFFFAOYSA-N 1-[5-tert-butyl-2-(3-fluorophenyl)pyrazol-3-yl]-3-[4-[2-(1h-pyrazol-4-yl)pyridin-4-yl]oxyphenyl]urea Chemical compound C=1C=CC(F)=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC(C=1)=CC=NC=1C=1C=NNC=1 LDJUQOAFQIOHDX-UHFFFAOYSA-N 0.000 claims 1
CQNCPAZVFXTDMN-UHFFFAOYSA-N 1-[5-tert-butyl-2-(4-cyanophenyl)pyrazol-3-yl]-3-[2-fluoro-5-(1-oxo-2,3-dihydroisoindol-4-yl)phenyl]urea Chemical compound N1=C(C(C)(C)C)C=C(NC(=O)NC=2C(=CC=C(C=2)C=2C=3CNC(=O)C=3C=CC=2)F)N1C1=CC=C(C#N)C=C1 CQNCPAZVFXTDMN-UHFFFAOYSA-N 0.000 claims 1
ZYQIEBSMCLNNHR-UHFFFAOYSA-N 1-[5-tert-butyl-2-(4-cyanophenyl)pyrazol-3-yl]-3-[2-fluoro-5-[2-(methylamino)-7-oxo-8-propan-2-ylpyrido[2,3-d]pyrimidin-6-yl]phenyl]urea Chemical compound O=C1N(C(C)C)C2=NC(NC)=NC=C2C=C1C(C=1)=CC=C(F)C=1NC(=O)NC1=CC(C(C)(C)C)=NN1C1=CC=C(C#N)C=C1 ZYQIEBSMCLNNHR-UHFFFAOYSA-N 0.000 claims 1
INGPEKJTUGOMAD-UHFFFAOYSA-N 1-[5-tert-butyl-2-(4-cyanophenyl)pyrazol-3-yl]-3-[3-(1-oxo-2,3-dihydroisoindol-4-yl)phenyl]urea Chemical compound N1=C(C(C)(C)C)C=C(NC(=O)NC=2C=C(C=CC=2)C=2C=3CNC(=O)C=3C=CC=2)N1C1=CC=C(C#N)C=C1 INGPEKJTUGOMAD-UHFFFAOYSA-N 0.000 claims 1
YMBLJQSRBWXZPS-UHFFFAOYSA-N 1-[5-tert-butyl-2-(4-cyanophenyl)pyrazol-3-yl]-3-[3-[2-(methylamino)-7-oxo-8-propan-2-ylpyrido[2,3-d]pyrimidin-6-yl]phenyl]urea Chemical compound O=C1N(C(C)C)C2=NC(NC)=NC=C2C=C1C(C=1)=CC=CC=1NC(=O)NC1=CC(C(C)(C)C)=NN1C1=CC=C(C#N)C=C1 YMBLJQSRBWXZPS-UHFFFAOYSA-N 0.000 claims 1
USTMPLLSTLQGFC-UHFFFAOYSA-N 1-[5-tert-butyl-2-(4-cyanophenyl)pyrazol-3-yl]-3-[3-[8-cyclopentyl-2-(methylamino)-7-oxopyrido[2,3-d]pyrimidin-6-yl]phenyl]urea Chemical compound O=C1N(C2CCCC2)C2=NC(NC)=NC=C2C=C1C(C=1)=CC=CC=1NC(=O)NC1=CC(C(C)(C)C)=NN1C1=CC=C(C#N)C=C1 USTMPLLSTLQGFC-UHFFFAOYSA-N 0.000 claims 1
LFTJLHATZDLNNO-UHFFFAOYSA-N 1-[5-tert-butyl-2-(4-cyanophenyl)pyrazol-3-yl]-3-[3-[8-methyl-2-(methylamino)-7-oxopyrido[2,3-d]pyrimidin-6-yl]phenyl]urea Chemical compound O=C1N(C)C2=NC(NC)=NC=C2C=C1C(C=1)=CC=CC=1NC(=O)NC1=CC(C(C)(C)C)=NN1C1=CC=C(C#N)C=C1 LFTJLHATZDLNNO-UHFFFAOYSA-N 0.000 claims 1
BFPDNXJZKPGKPS-UHFFFAOYSA-N 1-[5-tert-butyl-2-(4-cyanophenyl)pyrazol-3-yl]-3-[4-[2-(1-methylpyrazol-4-yl)pyridin-4-yl]oxyphenyl]urea Chemical compound C1=NN(C)C=C1C1=CC(OC=2C=CC(NC(=O)NC=3N(N=C(C=3)C(C)(C)C)C=3C=CC(=CC=3)C#N)=CC=2)=CC=N1 BFPDNXJZKPGKPS-UHFFFAOYSA-N 0.000 claims 1
RWTDYCQUPAVHRY-UHFFFAOYSA-N 1-[5-tert-butyl-2-(4-cyanophenyl)pyrazol-3-yl]-3-[4-methyl-3-[(4-morpholin-4-ylpyrimidin-2-yl)amino]phenyl]urea Chemical compound C1=C(NC=2N=C(C=CN=2)N2CCOCC2)C(C)=CC=C1NC(=O)NC1=CC(C(C)(C)C)=NN1C1=CC=C(C#N)C=C1 RWTDYCQUPAVHRY-UHFFFAOYSA-N 0.000 claims 1
DUEUIOOKWZQQQC-UHFFFAOYSA-N 1-[5-tert-butyl-2-(4-fluorophenyl)pyrazol-3-yl]-3-[2-fluoro-4-(1-oxo-2,3-dihydroisoindol-4-yl)phenyl]urea Chemical compound N1=C(C(C)(C)C)C=C(NC(=O)NC=2C(=CC(=CC=2)C=2C=3CNC(=O)C=3C=CC=2)F)N1C1=CC=C(F)C=C1 DUEUIOOKWZQQQC-UHFFFAOYSA-N 0.000 claims 1
JCJSSDRDJHSFET-UHFFFAOYSA-N 1-[5-tert-butyl-2-(4-fluorophenyl)pyrazol-3-yl]-3-[2-fluoro-4-[2-(1h-pyrazol-4-yl)pyridin-4-yl]oxyphenyl]urea Chemical compound C=1C=C(F)C=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)NC(C(=C1)F)=CC=C1OC(C=1)=CC=NC=1C=1C=NNC=1 JCJSSDRDJHSFET-UHFFFAOYSA-N 0.000 claims 1
IZCVDSKYZDQVEO-UHFFFAOYSA-N 1-[5-tert-butyl-2-(4-fluorophenyl)pyrazol-3-yl]-3-[2-fluoro-5-[8-methyl-2-(methylamino)-7-oxopyrido[2,3-d]pyrimidin-6-yl]phenyl]urea Chemical compound O=C1N(C)C2=NC(NC)=NC=C2C=C1C(C=1)=CC=C(F)C=1NC(=O)NC1=CC(C(C)(C)C)=NN1C1=CC=C(F)C=C1 IZCVDSKYZDQVEO-UHFFFAOYSA-N 0.000 claims 1
GIUMWKRORMCSIG-UHFFFAOYSA-N 1-[5-tert-butyl-2-(4-fluorophenyl)pyrazol-3-yl]-3-[3-(1-oxo-2,3-dihydroisoindol-4-yl)phenyl]urea Chemical compound N1=C(C(C)(C)C)C=C(NC(=O)NC=2C=C(C=CC=2)C=2C=3CNC(=O)C=3C=CC=2)N1C1=CC=C(F)C=C1 GIUMWKRORMCSIG-UHFFFAOYSA-N 0.000 claims 1
ANWARXZOERTFQO-UHFFFAOYSA-N 1-[5-tert-butyl-2-(4-fluorophenyl)pyrazol-3-yl]-3-[3-[2-(methylamino)-7-oxo-8-propan-2-ylpyrido[2,3-d]pyrimidin-6-yl]phenyl]urea Chemical compound O=C1N(C(C)C)C2=NC(NC)=NC=C2C=C1C(C=1)=CC=CC=1NC(=O)NC1=CC(C(C)(C)C)=NN1C1=CC=C(F)C=C1 ANWARXZOERTFQO-UHFFFAOYSA-N 0.000 claims 1
RNMRTYBTFPKNFY-UHFFFAOYSA-N 1-[5-tert-butyl-2-(4-fluorophenyl)pyrazol-3-yl]-3-[3-[8-(1-hydroxy-2-methylpropan-2-yl)-2-(methylamino)-7-oxopyrido[2,3-d]pyrimidin-6-yl]phenyl]urea Chemical compound O=C1N(C(C)(C)CO)C2=NC(NC)=NC=C2C=C1C(C=1)=CC=CC=1NC(=O)NC1=CC(C(C)(C)C)=NN1C1=CC=C(F)C=C1 RNMRTYBTFPKNFY-UHFFFAOYSA-N 0.000 claims 1
HXDPFMIIOASPHO-UHFFFAOYSA-N 1-[5-tert-butyl-2-(4-fluorophenyl)pyrazol-3-yl]-3-[3-[8-cyclopentyl-2-(methylamino)-7-oxopyrido[2,3-d]pyrimidin-6-yl]phenyl]urea Chemical compound O=C1N(C2CCCC2)C2=NC(NC)=NC=C2C=C1C(C=1)=CC=CC=1NC(=O)NC1=CC(C(C)(C)C)=NN1C1=CC=C(F)C=C1 HXDPFMIIOASPHO-UHFFFAOYSA-N 0.000 claims 1
QNGGGDJVDZCINU-UHFFFAOYSA-N 1-[5-tert-butyl-2-(4-fluorophenyl)pyrazol-3-yl]-3-[4-[2-(1-methylpyrazol-4-yl)pyridin-4-yl]oxyphenyl]urea Chemical compound C1=NN(C)C=C1C1=CC(OC=2C=CC(NC(=O)NC=3N(N=C(C=3)C(C)(C)C)C=3C=CC(F)=CC=3)=CC=2)=CC=N1 QNGGGDJVDZCINU-UHFFFAOYSA-N 0.000 claims 1
SBWULKQFRWQOKH-UHFFFAOYSA-N 1-[5-tert-butyl-2-(4-fluorophenyl)pyrazol-3-yl]-3-[4-[2-(1h-pyrazol-4-yl)pyridin-4-yl]oxyphenyl]urea Chemical compound C=1C=C(F)C=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC(C=1)=CC=NC=1C=1C=NNC=1 SBWULKQFRWQOKH-UHFFFAOYSA-N 0.000 claims 1
YQVARXOLLOVMGT-UHFFFAOYSA-N 1-[5-tert-butyl-2-(6-cyanopyridin-3-yl)pyrazol-3-yl]-3-[2-fluoro-4-[2-(1-methylpyrazol-4-yl)pyridin-4-yl]oxyphenyl]urea Chemical compound C1=NN(C)C=C1C1=CC(OC=2C=C(F)C(NC(=O)NC=3N(N=C(C=3)C(C)(C)C)C=3C=NC(=CC=3)C#N)=CC=2)=CC=N1 YQVARXOLLOVMGT-UHFFFAOYSA-N 0.000 claims 1
XAFUNXWBWFPRTM-UHFFFAOYSA-N 1-[5-tert-butyl-2-(6-cyanopyridin-3-yl)pyrazol-3-yl]-3-[2-fluoro-4-[2-(1h-pyrazol-4-yl)pyridin-4-yl]oxyphenyl]urea Chemical compound C=1C=C(C#N)N=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)NC(C(=C1)F)=CC=C1OC(C=1)=CC=NC=1C=1C=NNC=1 XAFUNXWBWFPRTM-UHFFFAOYSA-N 0.000 claims 1
QPWRLKOTRLIHDY-UHFFFAOYSA-N 1-[5-tert-butyl-2-(6-cyanopyridin-3-yl)pyrazol-3-yl]-3-[2-fluoro-5-[2-(methylamino)-7-oxo-8-propan-2-ylpyrido[2,3-d]pyrimidin-6-yl]phenyl]urea Chemical compound O=C1N(C(C)C)C2=NC(NC)=NC=C2C=C1C(C=1)=CC=C(F)C=1NC(=O)NC1=CC(C(C)(C)C)=NN1C1=CC=C(C#N)N=C1 QPWRLKOTRLIHDY-UHFFFAOYSA-N 0.000 claims 1
BHXZNEAFOJHKCG-UHFFFAOYSA-N 1-[5-tert-butyl-2-(6-cyanopyridin-3-yl)pyrazol-3-yl]-3-[3-[2-(methylamino)-7-oxo-8-propan-2-ylpyrido[2,3-d]pyrimidin-6-yl]phenyl]urea Chemical compound O=C1N(C(C)C)C2=NC(NC)=NC=C2C=C1C(C=1)=CC=CC=1NC(=O)NC1=CC(C(C)(C)C)=NN1C1=CC=C(C#N)N=C1 BHXZNEAFOJHKCG-UHFFFAOYSA-N 0.000 claims 1
KKSSVCHAFKCSJR-UHFFFAOYSA-N 1-[5-tert-butyl-2-(6-cyanopyridin-3-yl)pyrazol-3-yl]-3-[3-[8-(1-hydroxy-2-methylpropan-2-yl)-2-(methylamino)-7-oxopyrido[2,3-d]pyrimidin-6-yl]phenyl]urea Chemical compound O=C1N(C(C)(C)CO)C2=NC(NC)=NC=C2C=C1C(C=1)=CC=CC=1NC(=O)NC1=CC(C(C)(C)C)=NN1C1=CC=C(C#N)N=C1 KKSSVCHAFKCSJR-UHFFFAOYSA-N 0.000 claims 1
PTJMQKZGIRXYRU-UHFFFAOYSA-N 1-[5-tert-butyl-2-(6-cyanopyridin-3-yl)pyrazol-3-yl]-3-[3-[8-cyclopentyl-2-(methylamino)-7-oxopyrido[2,3-d]pyrimidin-6-yl]phenyl]urea Chemical compound O=C1N(C2CCCC2)C2=NC(NC)=NC=C2C=C1C(C=1)=CC=CC=1NC(=O)NC1=CC(C(C)(C)C)=NN1C1=CC=C(C#N)N=C1 PTJMQKZGIRXYRU-UHFFFAOYSA-N 0.000 claims 1
LAUCYAOCNXFCGQ-UHFFFAOYSA-N 1-[5-tert-butyl-2-(6-cyanopyridin-3-yl)pyrazol-3-yl]-3-[4-[2-(1h-pyrazol-4-yl)pyridin-4-yl]oxyphenyl]urea Chemical compound C=1C=C(C#N)N=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC(C=1)=CC=NC=1C=1C=NNC=1 LAUCYAOCNXFCGQ-UHFFFAOYSA-N 0.000 claims 1
125000004201 2,4-dichlorophenyl group Chemical group [H]C1=C([H])C(*)=C(Cl)C([H])=C1Cl 0.000 claims 1
125000004215 2,4-difluorophenyl group Chemical group [H]C1=C([H])C(*)=C(F)C([H])=C1F 0.000 claims 1
FFNVQNRYTPFDDP-UHFFFAOYSA-N 2-cyanopyridine Chemical compound N#CC1=CC=CC=N1 FFNVQNRYTPFDDP-UHFFFAOYSA-N 0.000 claims 1
125000004198 2-fluorophenyl group Chemical group [H]C1=C([H])C(F)=C(*)C([H])=C1[H] 0.000 claims 1
125000004189 3,4-dichlorophenyl group Chemical group [H]C1=C([H])C(Cl)=C(Cl)C([H])=C1* 0.000 claims 1
125000004211 3,5-difluorophenyl group Chemical group [H]C1=C(F)C([H])=C(*)C([H])=C1F 0.000 claims 1
125000006275 3-bromophenyl group Chemical group [H]C1=C([H])C(Br)=C([H])C(*)=C1[H] 0.000 claims 1
125000004179 3-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(Cl)=C1[H] 0.000 claims 1
IGAQKKUXSGNIHV-UHFFFAOYSA-N 4-[3-fluoro-4-[(1-propan-2-yl-3-quinazolin-6-ylpyrazol-4-yl)carbamoylamino]phenoxy]-n-methylpyridine-2-carboxamide Chemical compound C1=NC(C(=O)NC)=CC(OC=2C=C(F)C(NC(=O)NC=3C(=NN(C=3)C(C)C)C=3C=C4C=NC=NC4=CC=3)=CC=2)=C1 IGAQKKUXSGNIHV-UHFFFAOYSA-N 0.000 claims 1
WFOYTVICPBHDHE-UHFFFAOYSA-N 4-[3-fluoro-4-[(3-isoquinolin-6-yl-1-propan-2-ylpyrazol-4-yl)carbamoylamino]phenoxy]-n-methylpyridine-2-carboxamide Chemical compound C1=NC(C(=O)NC)=CC(OC=2C=C(F)C(NC(=O)NC=3C(=NN(C=3)C(C)C)C=3C=C4C=CN=CC4=CC=3)=CC=2)=C1 WFOYTVICPBHDHE-UHFFFAOYSA-N 0.000 claims 1
SOWYYQLTIDROJX-UHFFFAOYSA-N 4-[3-fluoro-4-[[1-propan-2-yl-3-(1,2,3,4-tetrahydroisoquinolin-6-yl)pyrazol-4-yl]carbamoylamino]phenoxy]-n-methylpyridine-2-carboxamide Chemical compound C1=NC(C(=O)NC)=CC(OC=2C=C(F)C(NC(=O)NC=3C(=NN(C=3)C(C)C)C=3C=C4CCNCC4=CC=3)=CC=2)=C1 SOWYYQLTIDROJX-UHFFFAOYSA-N 0.000 claims 1
YIEWRLWSVZAURN-UHFFFAOYSA-N 4-[3-fluoro-4-[[2-(2-methyl-3,4-dihydro-1h-isoquinolin-7-yl)-5-propan-2-ylpyrazol-3-yl]carbamoylamino]phenoxy]-n-methylpyridine-2-carboxamide Chemical compound C1=NC(C(=O)NC)=CC(OC=2C=C(F)C(NC(=O)NC=3N(N=C(C=3)C(C)C)C=3C=C4CN(C)CCC4=CC=3)=CC=2)=C1 YIEWRLWSVZAURN-UHFFFAOYSA-N 0.000 claims 1
ZGEATRRXBSUHFA-UHFFFAOYSA-N 4-[3-fluoro-4-[[3-(2-methyl-3,4-dihydro-1h-isoquinolin-7-yl)-1-propan-2-ylpyrazol-4-yl]carbamoylamino]phenoxy]-n-methylpyridine-2-carboxamide Chemical compound C1=NC(C(=O)NC)=CC(OC=2C=C(F)C(NC(=O)NC=3C(=NN(C=3)C(C)C)C=3C=C4CN(C)CCC4=CC=3)=CC=2)=C1 ZGEATRRXBSUHFA-UHFFFAOYSA-N 0.000 claims 1
YNEDEUSMGQBBPW-UHFFFAOYSA-N 4-[4-(carbamoylamino)phenoxy]-n-methylpyridine-2-carboxamide Chemical compound C1=NC(C(=O)NC)=CC(OC=2C=CC(NC(N)=O)=CC=2)=C1 YNEDEUSMGQBBPW-UHFFFAOYSA-N 0.000 claims 1
FUPWRYYWSBKYBN-UHFFFAOYSA-N 4-[4-[(1-tert-butyl-3-isoquinolin-6-ylpyrazol-4-yl)carbamoylamino]phenoxy]-n-methylpyridine-2-carboxamide Chemical compound C1=NC(C(=O)NC)=CC(OC=2C=CC(NC(=O)NC=3C(=NN(C=3)C(C)(C)C)C=3C=C4C=CN=CC4=CC=3)=CC=2)=C1 FUPWRYYWSBKYBN-UHFFFAOYSA-N 0.000 claims 1
GISBHWVINALPMT-UHFFFAOYSA-N 4-[4-[(1-tert-butyl-3-quinazolin-6-ylpyrazol-4-yl)carbamoylamino]phenoxy]-n-methylpyridine-2-carboxamide Chemical compound C1=NC(C(=O)NC)=CC(OC=2C=CC(NC(=O)NC=3C(=NN(C=3)C(C)(C)C)C=3C=C4C=NC=NC4=CC=3)=CC=2)=C1 GISBHWVINALPMT-UHFFFAOYSA-N 0.000 claims 1
MAZMNAMLRSUJRB-UHFFFAOYSA-N 4-[4-[(1-tert-butyl-3-quinolin-6-ylpyrazol-4-yl)carbamoylamino]-3-fluorophenoxy]-n-methylpyridine-2-carboxamide Chemical compound C1=NC(C(=O)NC)=CC(OC=2C=C(F)C(NC(=O)NC=3C(=NN(C=3)C(C)(C)C)C=3C=C4C=CC=NC4=CC=3)=CC=2)=C1 MAZMNAMLRSUJRB-UHFFFAOYSA-N 0.000 claims 1
BQPKRIWSGGFIHS-UHFFFAOYSA-N 4-[4-[(1-tert-butyl-3-quinolin-6-ylpyrazol-4-yl)carbamoylamino]phenoxy]-n-methylpyridine-2-carboxamide Chemical compound C1=NC(C(=O)NC)=CC(OC=2C=CC(NC(=O)NC=3C(=NN(C=3)C(C)(C)C)C=3C=C4C=CC=NC4=CC=3)=CC=2)=C1 BQPKRIWSGGFIHS-UHFFFAOYSA-N 0.000 claims 1
HANIRRVQDGRLMN-UHFFFAOYSA-N 4-[4-[(5-tert-butyl-2-quinazolin-6-ylpyrazol-3-yl)carbamoylamino]phenoxy]-n-methylpyridine-2-carboxamide Chemical compound C1=NC(C(=O)NC)=CC(OC=2C=CC(NC(=O)NC=3N(N=C(C=3)C(C)(C)C)C=3C=C4C=NC=NC4=CC=3)=CC=2)=C1 HANIRRVQDGRLMN-UHFFFAOYSA-N 0.000 claims 1
CLOXJJHRUOLBEJ-UHFFFAOYSA-N 4-[4-[(5-tert-butyl-2-quinolin-6-ylpyrazol-3-yl)carbamoylamino]phenoxy]-n-methylpyridine-2-carboxamide Chemical compound C1=NC(C(=O)NC)=CC(OC=2C=CC(NC(=O)NC=3N(N=C(C=3)C(C)(C)C)C=3C=C4C=CC=NC4=CC=3)=CC=2)=C1 CLOXJJHRUOLBEJ-UHFFFAOYSA-N 0.000 claims 1
IETHWVROQUCYBA-UHFFFAOYSA-N 4-[4-[[1-tert-butyl-3-(1,2,3,4-tetrahydroisoquinolin-6-yl)pyrazol-4-yl]carbamoylamino]-3-fluorophenoxy]-n-methylpyridine-2-carboxamide Chemical compound C1=NC(C(=O)NC)=CC(OC=2C=C(F)C(NC(=O)NC=3C(=NN(C=3)C(C)(C)C)C=3C=C4CCNCC4=CC=3)=CC=2)=C1 IETHWVROQUCYBA-UHFFFAOYSA-N 0.000 claims 1
OBVLPPPLWGGNGO-UHFFFAOYSA-N 4-[4-[[1-tert-butyl-3-(1,2,3,4-tetrahydroisoquinolin-6-yl)pyrazol-4-yl]carbamoylamino]phenoxy]-n-methylpyridine-2-carboxamide Chemical compound C1=NC(C(=O)NC)=CC(OC=2C=CC(NC(=O)NC=3C(=NN(C=3)C(C)(C)C)C=3C=C4CCNCC4=CC=3)=CC=2)=C1 OBVLPPPLWGGNGO-UHFFFAOYSA-N 0.000 claims 1
VKUSZWZRDAWMTG-UHFFFAOYSA-N 4-[4-[[1-tert-butyl-3-(1h-indazol-5-yl)pyrazol-4-yl]carbamoylamino]phenoxy]-n-methylpyridine-2-carboxamide Chemical compound C1=NC(C(=O)NC)=CC(OC=2C=CC(NC(=O)NC=3C(=NN(C=3)C(C)(C)C)C=3C=C4C=NNC4=CC=3)=CC=2)=C1 VKUSZWZRDAWMTG-UHFFFAOYSA-N 0.000 claims 1
LMILFRPVQBUVSE-UHFFFAOYSA-N 4-[4-[[1-tert-butyl-3-(2-methyl-3,4-dihydro-1h-isoquinolin-7-yl)pyrazol-4-yl]carbamoylamino]-3-fluorophenoxy]-n-methylpyridine-2-carboxamide Chemical compound C1=NC(C(=O)NC)=CC(OC=2C=C(F)C(NC(=O)NC=3C(=NN(C=3)C(C)(C)C)C=3C=C4CN(C)CCC4=CC=3)=CC=2)=C1 LMILFRPVQBUVSE-UHFFFAOYSA-N 0.000 claims 1
OATMWEVBBBMASO-UHFFFAOYSA-N 4-[4-[[1-tert-butyl-3-(2-methyl-3,4-dihydro-1h-isoquinolin-7-yl)pyrazol-4-yl]carbamoylamino]phenoxy]-n-methylpyridine-2-carboxamide Chemical compound C1=NC(C(=O)NC)=CC(OC=2C=CC(NC(=O)NC=3C(=NN(C=3)C(C)(C)C)C=3C=C4CN(C)CCC4=CC=3)=CC=2)=C1 OATMWEVBBBMASO-UHFFFAOYSA-N 0.000 claims 1
YMZBXOKIPGXJBF-UHFFFAOYSA-N 4-[4-[[2-(1,2-benzoxazol-5-yl)-5-propan-2-ylpyrazol-3-yl]carbamoylamino]-3-fluorophenoxy]-n-methylpyridine-2-carboxamide Chemical compound C1=NC(C(=O)NC)=CC(OC=2C=C(F)C(NC(=O)NC=3N(N=C(C=3)C(C)C)C=3C=C4C=NOC4=CC=3)=CC=2)=C1 YMZBXOKIPGXJBF-UHFFFAOYSA-N 0.000 claims 1
IDLRLYQWEJUHIE-UHFFFAOYSA-N 4-[4-[[2-(1,2-benzoxazol-5-yl)-5-tert-butylpyrazol-3-yl]carbamoylamino]phenoxy]-n-methylpyridine-2-carboxamide Chemical compound C1=NC(C(=O)NC)=CC(OC=2C=CC(NC(=O)NC=3N(N=C(C=3)C(C)(C)C)C=3C=C4C=NOC4=CC=3)=CC=2)=C1 IDLRLYQWEJUHIE-UHFFFAOYSA-N 0.000 claims 1
ZJYOLAQGVLKWEG-UHFFFAOYSA-N 4-[4-[[2-(1,3-benzothiazol-5-yl)-5-propan-2-ylpyrazol-3-yl]carbamoylamino]-3-fluorophenoxy]-n-methylpyridine-2-carboxamide Chemical compound C1=NC(C(=O)NC)=CC(OC=2C=C(F)C(NC(=O)NC=3N(N=C(C=3)C(C)C)C=3C=C4N=CSC4=CC=3)=CC=2)=C1 ZJYOLAQGVLKWEG-UHFFFAOYSA-N 0.000 claims 1
HPRRWWCORGTGOK-UHFFFAOYSA-N 4-[4-[[2-(1,3-benzothiazol-5-yl)-5-tert-butylpyrazol-3-yl]carbamoylamino]phenoxy]-n-methylpyridine-2-carboxamide Chemical compound C1=NC(C(=O)NC)=CC(OC=2C=CC(NC(=O)NC=3N(N=C(C=3)C(C)(C)C)C=3C=C4N=CSC4=CC=3)=CC=2)=C1 HPRRWWCORGTGOK-UHFFFAOYSA-N 0.000 claims 1
UZACCPPXPRKJTJ-UHFFFAOYSA-N 4-[4-[[2-(1,3-benzoxazol-5-yl)-5-propan-2-ylpyrazol-3-yl]carbamoylamino]-3-fluorophenoxy]-n-methylpyridine-2-carboxamide Chemical compound C1=NC(C(=O)NC)=CC(OC=2C=C(F)C(NC(=O)NC=3N(N=C(C=3)C(C)C)C=3C=C4N=COC4=CC=3)=CC=2)=C1 UZACCPPXPRKJTJ-UHFFFAOYSA-N 0.000 claims 1
SBTMBDFKJNQJJC-UHFFFAOYSA-N 4-[4-[[2-(1,3-benzoxazol-5-yl)-5-propan-2-ylpyrazol-3-yl]carbamoylamino]phenoxy]-n-methylpyridine-2-carboxamide Chemical compound C1=NC(C(=O)NC)=CC(OC=2C=CC(NC(=O)NC=3N(N=C(C=3)C(C)C)C=3C=C4N=COC4=CC=3)=CC=2)=C1 SBTMBDFKJNQJJC-UHFFFAOYSA-N 0.000 claims 1
LPZNTYNEUOJCDX-UHFFFAOYSA-N 4-[4-[[2-(1,3-benzoxazol-5-yl)-5-tert-butylpyrazol-3-yl]carbamoylamino]-3-fluorophenoxy]-n-methylpyridine-2-carboxamide Chemical compound C1=NC(C(=O)NC)=CC(OC=2C=C(F)C(NC(=O)NC=3N(N=C(C=3)C(C)(C)C)C=3C=C4N=COC4=CC=3)=CC=2)=C1 LPZNTYNEUOJCDX-UHFFFAOYSA-N 0.000 claims 1
BUIHYINXKRIPKX-UHFFFAOYSA-N 4-[4-[[2-(1,3-benzoxazol-5-yl)-5-tert-butylpyrazol-3-yl]carbamoylamino]phenoxy]-n-methylpyridine-2-carboxamide Chemical compound C1=NC(C(=O)NC)=CC(OC=2C=CC(NC(=O)NC=3N(N=C(C=3)C(C)(C)C)C=3C=C4N=COC4=CC=3)=CC=2)=C1 BUIHYINXKRIPKX-UHFFFAOYSA-N 0.000 claims 1
DVINCBUNHJLUKO-UHFFFAOYSA-N 4-[4-[[2-(1h-indazol-5-yl)-5-propan-2-ylpyrazol-3-yl]carbamoylamino]phenoxy]-n-methylpyridine-2-carboxamide Chemical compound C1=NC(C(=O)NC)=CC(OC=2C=CC(NC(=O)NC=3N(N=C(C=3)C(C)C)C=3C=C4C=NNC4=CC=3)=CC=2)=C1 DVINCBUNHJLUKO-UHFFFAOYSA-N 0.000 claims 1
WZYKOIIHJOPVJJ-UHFFFAOYSA-N 4-[4-[[2-(3h-benzimidazol-5-yl)-5-tert-butylpyrazol-3-yl]carbamoylamino]-3-fluorophenoxy]-n-methylpyridine-2-carboxamide Chemical compound C1=NC(C(=O)NC)=CC(OC=2C=C(F)C(NC(=O)NC=3N(N=C(C=3)C(C)(C)C)C=3C=C4N=CNC4=CC=3)=CC=2)=C1 WZYKOIIHJOPVJJ-UHFFFAOYSA-N 0.000 claims 1
OHBJJKXTDIAVPR-UHFFFAOYSA-N 4-[4-[[2-(3h-benzimidazol-5-yl)-5-tert-butylpyrazol-3-yl]carbamoylamino]phenoxy]-n-methylpyridine-2-carboxamide Chemical compound C1=NC(C(=O)NC)=CC(OC=2C=CC(NC(=O)NC=3N(N=C(C=3)C(C)(C)C)C=3C=C4N=CNC4=CC=3)=CC=2)=C1 OHBJJKXTDIAVPR-UHFFFAOYSA-N 0.000 claims 1
CMRJHMZCBOEJKR-UHFFFAOYSA-N 4-[4-[[3-(1,2-benzoxazol-5-yl)-1-propan-2-ylpyrazol-4-yl]carbamoylamino]phenoxy]-n-methylpyridine-2-carboxamide Chemical compound C1=NC(C(=O)NC)=CC(OC=2C=CC(NC(=O)NC=3C(=NN(C=3)C(C)C)C=3C=C4C=NOC4=CC=3)=CC=2)=C1 CMRJHMZCBOEJKR-UHFFFAOYSA-N 0.000 claims 1
CFKSNFKNYAJCAL-UHFFFAOYSA-N 4-[4-[[3-(1,2-benzoxazol-5-yl)-1-tert-butylpyrazol-4-yl]carbamoylamino]phenoxy]-n-methylpyridine-2-carboxamide Chemical compound C1=NC(C(=O)NC)=CC(OC=2C=CC(NC(=O)NC=3C(=NN(C=3)C(C)(C)C)C=3C=C4C=NOC4=CC=3)=CC=2)=C1 CFKSNFKNYAJCAL-UHFFFAOYSA-N 0.000 claims 1
XIYNUZOYCJMVJJ-UHFFFAOYSA-N 4-[4-[[3-(1,3-benzothiazol-5-yl)-1-propan-2-ylpyrazol-4-yl]carbamoylamino]-3-fluorophenoxy]-n-methylpyridine-2-carboxamide Chemical compound C1=NC(C(=O)NC)=CC(OC=2C=C(F)C(NC(=O)NC=3C(=NN(C=3)C(C)C)C=3C=C4N=CSC4=CC=3)=CC=2)=C1 XIYNUZOYCJMVJJ-UHFFFAOYSA-N 0.000 claims 1
RCSLSXGNPDIHKL-UHFFFAOYSA-N 4-[4-[[3-(1,3-benzothiazol-5-yl)-1-tert-butylpyrazol-4-yl]carbamoylamino]-3-fluorophenoxy]-n-methylpyridine-2-carboxamide Chemical compound C1=NC(C(=O)NC)=CC(OC=2C=C(F)C(NC(=O)NC=3C(=NN(C=3)C(C)(C)C)C=3C=C4N=CSC4=CC=3)=CC=2)=C1 RCSLSXGNPDIHKL-UHFFFAOYSA-N 0.000 claims 1
WAPFXPGWVBCTGH-UHFFFAOYSA-N 4-[4-[[3-(1,3-benzothiazol-5-yl)-1-tert-butylpyrazol-4-yl]carbamoylamino]phenoxy]-n-methylpyridine-2-carboxamide Chemical compound C1=NC(C(=O)NC)=CC(OC=2C=CC(NC(=O)NC=3C(=NN(C=3)C(C)(C)C)C=3C=C4N=CSC4=CC=3)=CC=2)=C1 WAPFXPGWVBCTGH-UHFFFAOYSA-N 0.000 claims 1
ACTOZARLXUWCBO-UHFFFAOYSA-N 4-[4-[[3-(1,3-benzoxazol-5-yl)-1-propan-2-ylpyrazol-4-yl]carbamoylamino]phenoxy]-n-methylpyridine-2-carboxamide Chemical compound C1=NC(C(=O)NC)=CC(OC=2C=CC(NC(=O)NC=3C(=NN(C=3)C(C)C)C=3C=C4N=COC4=CC=3)=CC=2)=C1 ACTOZARLXUWCBO-UHFFFAOYSA-N 0.000 claims 1
CPJVPQPLGWGPFF-UHFFFAOYSA-N 4-[4-[[3-(1,3-benzoxazol-5-yl)-1-tert-butylpyrazol-4-yl]carbamoylamino]phenoxy]-n-methylpyridine-2-carboxamide Chemical compound C1=NC(C(=O)NC)=CC(OC=2C=CC(NC(=O)NC=3C(=NN(C=3)C(C)(C)C)C=3C=C4N=COC4=CC=3)=CC=2)=C1 CPJVPQPLGWGPFF-UHFFFAOYSA-N 0.000 claims 1
AFEZJRXOYSOVNR-UHFFFAOYSA-N 4-[4-[[3-(3h-benzimidazol-5-yl)-1-propan-2-ylpyrazol-4-yl]carbamoylamino]phenoxy]-n-methylpyridine-2-carboxamide Chemical compound C1=NC(C(=O)NC)=CC(OC=2C=CC(NC(=O)NC=3C(=NN(C=3)C(C)C)C=3C=C4N=CNC4=CC=3)=CC=2)=C1 AFEZJRXOYSOVNR-UHFFFAOYSA-N 0.000 claims 1
SNYUOPSIQRPGRC-UHFFFAOYSA-N 4-[4-[[3-(3h-benzimidazol-5-yl)-1-tert-butylpyrazol-4-yl]carbamoylamino]phenoxy]-n-methylpyridine-2-carboxamide Chemical compound C1=NC(C(=O)NC)=CC(OC=2C=CC(NC(=O)NC=3C(=NN(C=3)C(C)(C)C)C=3C=C4N=CNC4=CC=3)=CC=2)=C1 SNYUOPSIQRPGRC-UHFFFAOYSA-N 0.000 claims 1
PMRLOUDIAGOBHB-UHFFFAOYSA-N 4-[4-[[5-tert-butyl-2-(1,2,3,4-tetrahydroisoquinolin-6-yl)pyrazol-3-yl]carbamoylamino]-3-fluorophenoxy]-n-methylpyridine-2-carboxamide Chemical compound C1=NC(C(=O)NC)=CC(OC=2C=C(F)C(NC(=O)NC=3N(N=C(C=3)C(C)(C)C)C=3C=C4CCNCC4=CC=3)=CC=2)=C1 PMRLOUDIAGOBHB-UHFFFAOYSA-N 0.000 claims 1
HBFBAFUOVPDFID-UHFFFAOYSA-N 4-[4-[[5-tert-butyl-2-(1,2,3,4-tetrahydroisoquinolin-6-yl)pyrazol-3-yl]carbamoylamino]phenoxy]-n-methylpyridine-2-carboxamide Chemical compound C1=NC(C(=O)NC)=CC(OC=2C=CC(NC(=O)NC=3N(N=C(C=3)C(C)(C)C)C=3C=C4CCNCC4=CC=3)=CC=2)=C1 HBFBAFUOVPDFID-UHFFFAOYSA-N 0.000 claims 1
WYPQLETZHQEIDJ-UHFFFAOYSA-N 4-[4-[[5-tert-butyl-2-(1h-indazol-5-yl)pyrazol-3-yl]carbamoylamino]-3-fluorophenoxy]-n-methylpyridine-2-carboxamide Chemical compound C1=NC(C(=O)NC)=CC(OC=2C=C(F)C(NC(=O)NC=3N(N=C(C=3)C(C)(C)C)C=3C=C4C=NNC4=CC=3)=CC=2)=C1 WYPQLETZHQEIDJ-UHFFFAOYSA-N 0.000 claims 1
RRXUKKAZKKXIRL-UHFFFAOYSA-N 4-[4-[[5-tert-butyl-2-(1h-indazol-5-yl)pyrazol-3-yl]carbamoylamino]phenoxy]-n-methylpyridine-2-carboxamide Chemical compound C1=NC(C(=O)NC)=CC(OC=2C=CC(NC(=O)NC=3N(N=C(C=3)C(C)(C)C)C=3C=C4C=NNC4=CC=3)=CC=2)=C1 RRXUKKAZKKXIRL-UHFFFAOYSA-N 0.000 claims 1
SQTDTJRFBHYDCS-UHFFFAOYSA-N 4-[4-[[5-tert-butyl-2-(2-methyl-3,4-dihydro-1h-isoquinolin-6-yl)pyrazol-3-yl]carbamoylamino]-3-fluorophenoxy]-n-methylpyridine-2-carboxamide Chemical compound C1=NC(C(=O)NC)=CC(OC=2C=C(F)C(NC(=O)NC=3N(N=C(C=3)C(C)(C)C)C=3C=C4CCN(C)CC4=CC=3)=CC=2)=C1 SQTDTJRFBHYDCS-UHFFFAOYSA-N 0.000 claims 1
HBAIRZKEWBYDHZ-UHFFFAOYSA-N 4-[4-[[5-tert-butyl-2-(2-methyl-3,4-dihydro-1h-isoquinolin-6-yl)pyrazol-3-yl]carbamoylamino]phenoxy]-n-methylpyridine-2-carboxamide Chemical compound C1=NC(C(=O)NC)=CC(OC=2C=CC(NC(=O)NC=3N(N=C(C=3)C(C)(C)C)C=3C=C4CCN(C)CC4=CC=3)=CC=2)=C1 HBAIRZKEWBYDHZ-UHFFFAOYSA-N 0.000 claims 1
FJAXHBPIKSLEQA-UHFFFAOYSA-N 4-[4-[[5-tert-butyl-2-(2-methyl-3,4-dihydro-1h-isoquinolin-7-yl)pyrazol-3-yl]carbamoylamino]phenoxy]-n-methylpyridine-2-carboxamide Chemical compound C1=NC(C(=O)NC)=CC(OC=2C=CC(NC(=O)NC=3N(N=C(C=3)C(C)(C)C)C=3C=C4CN(C)CCC4=CC=3)=CC=2)=C1 FJAXHBPIKSLEQA-UHFFFAOYSA-N 0.000 claims 1
125000004800 4-bromophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Br 0.000 claims 1
125000006163 5-membered heteroaryl group Chemical group 0.000 claims 1
RRHGJUQNOFWUDK-UHFFFAOYSA-N Isoprene Chemical compound CC(=C)C=C RRHGJUQNOFWUDK-UHFFFAOYSA-N 0.000 claims 1
239000000654 additive Substances 0.000 claims 1
230000000996 additive effect Effects 0.000 claims 1
239000002671 adjuvant Substances 0.000 claims 1
239000003085 diluting agent Substances 0.000 claims 1
229910052731 fluorine Inorganic materials 0.000 claims 1
125000004531 indol-5-yl group Chemical group [H]N1C([H])=C([H])C2=C([H])C(*)=C([H])C([H])=C12 0.000 claims 1
125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
BQZTVDXYAJFIHC-UHFFFAOYSA-N n-[4-[3-fluoro-4-[(1-propan-2-yl-3-quinazolin-6-ylpyrazol-4-yl)carbamoylamino]phenoxy]pyridin-2-yl]acetamide Chemical compound C=1C=C2N=CN=CC2=CC=1C1=NN(C(C)C)C=C1NC(=O)NC(C(=C1)F)=CC=C1OC1=CC=NC(NC(C)=O)=C1 BQZTVDXYAJFIHC-UHFFFAOYSA-N 0.000 claims 1
SNULQHPMVCRNKK-UHFFFAOYSA-N n-[4-[3-fluoro-4-[(1-propan-2-yl-3-quinolin-6-ylpyrazol-4-yl)carbamoylamino]phenoxy]pyridin-2-yl]acetamide Chemical compound C=1C=C2N=CC=CC2=CC=1C1=NN(C(C)C)C=C1NC(=O)NC(C(=C1)F)=CC=C1OC1=CC=NC(NC(C)=O)=C1 SNULQHPMVCRNKK-UHFFFAOYSA-N 0.000 claims 1
RULOJWCUAOVIOM-UHFFFAOYSA-N n-[4-[3-fluoro-4-[(2-isoquinolin-6-yl-5-propan-2-ylpyrazol-3-yl)carbamoylamino]phenoxy]pyridin-2-yl]acetamide Chemical compound C=1C=C2C=NC=CC2=CC=1N1N=C(C(C)C)C=C1NC(=O)NC(C(=C1)F)=CC=C1OC1=CC=NC(NC(C)=O)=C1 RULOJWCUAOVIOM-UHFFFAOYSA-N 0.000 claims 1
YAXYZEACCIQYHW-UHFFFAOYSA-N n-[4-[3-fluoro-4-[(3-isoquinolin-6-yl-1-propan-2-ylpyrazol-4-yl)carbamoylamino]phenoxy]pyridin-2-yl]acetamide Chemical compound C=1C=C2C=NC=CC2=CC=1C1=NN(C(C)C)C=C1NC(=O)NC(C(=C1)F)=CC=C1OC1=CC=NC(NC(C)=O)=C1 YAXYZEACCIQYHW-UHFFFAOYSA-N 0.000 claims 1
ZOVGIGIFPXBUGH-UHFFFAOYSA-N n-[4-[3-fluoro-4-[(5-propan-2-yl-2-quinazolin-6-ylpyrazol-3-yl)carbamoylamino]phenoxy]pyridin-2-yl]acetamide Chemical compound C=1C=C2N=CN=CC2=CC=1N1N=C(C(C)C)C=C1NC(=O)NC(C(=C1)F)=CC=C1OC1=CC=NC(NC(C)=O)=C1 ZOVGIGIFPXBUGH-UHFFFAOYSA-N 0.000 claims 1
GIZJXGVAZMEGSM-UHFFFAOYSA-N n-[4-[3-fluoro-4-[(5-propan-2-yl-2-quinolin-6-ylpyrazol-3-yl)carbamoylamino]phenoxy]pyridin-2-yl]acetamide Chemical compound C=1C=C2N=CC=CC2=CC=1N1N=C(C(C)C)C=C1NC(=O)NC(C(=C1)F)=CC=C1OC1=CC=NC(NC(C)=O)=C1 GIZJXGVAZMEGSM-UHFFFAOYSA-N 0.000 claims 1
QXFWLHQLTIWHNU-UHFFFAOYSA-N n-[4-[3-fluoro-4-[[2-(2-methyl-3,4-dihydro-1h-isoquinolin-6-yl)-5-propan-2-ylpyrazol-3-yl]carbamoylamino]phenoxy]pyridin-2-yl]acetamide Chemical compound C=1C=C2CN(C)CCC2=CC=1N1N=C(C(C)C)C=C1NC(=O)NC(C(=C1)F)=CC=C1OC1=CC=NC(NC(C)=O)=C1 QXFWLHQLTIWHNU-UHFFFAOYSA-N 0.000 claims 1
PJRWIYDITKEOOO-UHFFFAOYSA-N n-[4-[3-fluoro-4-[[2-(2-methyl-3,4-dihydro-1h-isoquinolin-7-yl)-5-propan-2-ylpyrazol-3-yl]carbamoylamino]phenoxy]pyridin-2-yl]acetamide Chemical compound C=1C=C2CCN(C)CC2=CC=1N1N=C(C(C)C)C=C1NC(=O)NC(C(=C1)F)=CC=C1OC1=CC=NC(NC(C)=O)=C1 PJRWIYDITKEOOO-UHFFFAOYSA-N 0.000 claims 1
MDWQZEIFZHERBV-UHFFFAOYSA-N n-[4-[3-fluoro-4-[[3-(2-methyl-3,4-dihydro-1h-isoquinolin-6-yl)-1-propan-2-ylpyrazol-4-yl]carbamoylamino]phenoxy]pyridin-2-yl]acetamide Chemical compound C=1C=C2CN(C)CCC2=CC=1C1=NN(C(C)C)C=C1NC(=O)NC(C(=C1)F)=CC=C1OC1=CC=NC(NC(C)=O)=C1 MDWQZEIFZHERBV-UHFFFAOYSA-N 0.000 claims 1
TUPZOEPSJLGGCA-UHFFFAOYSA-N n-[4-[3-fluoro-4-[[3-(2-methyl-3,4-dihydro-1h-isoquinolin-7-yl)-1-propan-2-ylpyrazol-4-yl]carbamoylamino]phenoxy]pyridin-2-yl]acetamide Chemical compound C=1C=C2CCN(C)CC2=CC=1C1=NN(C(C)C)C=C1NC(=O)NC(C(=C1)F)=CC=C1OC1=CC=NC(NC(C)=O)=C1 TUPZOEPSJLGGCA-UHFFFAOYSA-N 0.000 claims 1
NTMNRZWRAGSWMR-UHFFFAOYSA-N n-[4-[3-fluoro-4-[[5-propan-2-yl-2-(1,2,3,4-tetrahydroisoquinolin-6-yl)pyrazol-3-yl]carbamoylamino]phenoxy]pyridin-2-yl]acetamide Chemical compound C=1C=C2CNCCC2=CC=1N1N=C(C(C)C)C=C1NC(=O)NC(C(=C1)F)=CC=C1OC1=CC=NC(NC(C)=O)=C1 NTMNRZWRAGSWMR-UHFFFAOYSA-N 0.000 claims 1
HYAIBBBHZLPPQZ-UHFFFAOYSA-N n-[4-[4-[(1-propan-2-yl-3-quinazolin-6-ylpyrazol-4-yl)carbamoylamino]phenoxy]pyridin-2-yl]acetamide Chemical compound C=1C=C2N=CN=CC2=CC=1C1=NN(C(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC1=CC=NC(NC(C)=O)=C1 HYAIBBBHZLPPQZ-UHFFFAOYSA-N 0.000 claims 1
XBTTZBVWQREUJU-UHFFFAOYSA-N n-[4-[4-[(1-tert-butyl-3-isoquinolin-6-ylpyrazol-4-yl)carbamoylamino]-3-fluorophenoxy]pyridin-2-yl]acetamide Chemical compound C1=NC(NC(=O)C)=CC(OC=2C=C(F)C(NC(=O)NC=3C(=NN(C=3)C(C)(C)C)C=3C=C4C=CN=CC4=CC=3)=CC=2)=C1 XBTTZBVWQREUJU-UHFFFAOYSA-N 0.000 claims 1
PTRNAAXUMKHPQW-UHFFFAOYSA-N n-[4-[4-[(1-tert-butyl-3-isoquinolin-6-ylpyrazol-4-yl)carbamoylamino]phenoxy]pyridin-2-yl]acetamide Chemical compound C1=NC(NC(=O)C)=CC(OC=2C=CC(NC(=O)NC=3C(=NN(C=3)C(C)(C)C)C=3C=C4C=CN=CC4=CC=3)=CC=2)=C1 PTRNAAXUMKHPQW-UHFFFAOYSA-N 0.000 claims 1
UEQMSUICOMDRHY-UHFFFAOYSA-N n-[4-[4-[(1-tert-butyl-3-quinolin-6-ylpyrazol-4-yl)carbamoylamino]-3-fluorophenoxy]pyridin-2-yl]acetamide Chemical compound C1=NC(NC(=O)C)=CC(OC=2C=C(F)C(NC(=O)NC=3C(=NN(C=3)C(C)(C)C)C=3C=C4C=CC=NC4=CC=3)=CC=2)=C1 UEQMSUICOMDRHY-UHFFFAOYSA-N 0.000 claims 1
OWOBIYOYQZNYNG-UHFFFAOYSA-N n-[4-[4-[(3-isoquinolin-6-yl-1-propan-2-ylpyrazol-4-yl)carbamoylamino]phenoxy]pyridin-2-yl]acetamide Chemical compound C=1C=C2C=NC=CC2=CC=1C1=NN(C(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC1=CC=NC(NC(C)=O)=C1 OWOBIYOYQZNYNG-UHFFFAOYSA-N 0.000 claims 1
BYHGRCSYLHTCSO-UHFFFAOYSA-N n-[4-[4-[(5-propan-2-yl-2-quinazolin-6-ylpyrazol-3-yl)carbamoylamino]phenoxy]pyridin-2-yl]acetamide Chemical compound C=1C=C2N=CN=CC2=CC=1N1N=C(C(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC1=CC=NC(NC(C)=O)=C1 BYHGRCSYLHTCSO-UHFFFAOYSA-N 0.000 claims 1
DVUJLGCHHCJOKP-UHFFFAOYSA-N n-[4-[4-[(5-propan-2-yl-2-quinolin-6-ylpyrazol-3-yl)carbamoylamino]phenoxy]pyridin-2-yl]acetamide Chemical compound C=1C=C2N=CC=CC2=CC=1N1N=C(C(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC1=CC=NC(NC(C)=O)=C1 DVUJLGCHHCJOKP-UHFFFAOYSA-N 0.000 claims 1
XWONEIXIAHIHDK-UHFFFAOYSA-N n-[4-[4-[(5-tert-butyl-2-quinazolin-6-ylpyrazol-3-yl)carbamoylamino]-3-fluorophenoxy]pyridin-2-yl]acetamide Chemical compound C1=NC(NC(=O)C)=CC(OC=2C=C(F)C(NC(=O)NC=3N(N=C(C=3)C(C)(C)C)C=3C=C4C=NC=NC4=CC=3)=CC=2)=C1 XWONEIXIAHIHDK-UHFFFAOYSA-N 0.000 claims 1
TZMGIYOBAHURSN-UHFFFAOYSA-N n-[4-[4-[(5-tert-butyl-2-quinazolin-6-ylpyrazol-3-yl)carbamoylamino]phenoxy]pyridin-2-yl]acetamide Chemical compound C1=NC(NC(=O)C)=CC(OC=2C=CC(NC(=O)NC=3N(N=C(C=3)C(C)(C)C)C=3C=C4C=NC=NC4=CC=3)=CC=2)=C1 TZMGIYOBAHURSN-UHFFFAOYSA-N 0.000 claims 1
WGOSXJWSGZBMAU-UHFFFAOYSA-N n-[4-[4-[(5-tert-butyl-2-quinolin-6-ylpyrazol-3-yl)carbamoylamino]-3-fluorophenoxy]pyridin-2-yl]acetamide Chemical compound C1=NC(NC(=O)C)=CC(OC=2C=C(F)C(NC(=O)NC=3N(N=C(C=3)C(C)(C)C)C=3C=C4C=CC=NC4=CC=3)=CC=2)=C1 WGOSXJWSGZBMAU-UHFFFAOYSA-N 0.000 claims 1
WXNJCQWMWAMUES-UHFFFAOYSA-N n-[4-[4-[(5-tert-butyl-2-quinolin-6-ylpyrazol-3-yl)carbamoylamino]phenoxy]pyridin-2-yl]acetamide Chemical compound C1=NC(NC(=O)C)=CC(OC=2C=CC(NC(=O)NC=3N(N=C(C=3)C(C)(C)C)C=3C=C4C=CC=NC4=CC=3)=CC=2)=C1 WXNJCQWMWAMUES-UHFFFAOYSA-N 0.000 claims 1
QALSDSLUGNRFPG-UHFFFAOYSA-N n-[4-[4-[[1-tert-butyl-3-(1h-indazol-5-yl)pyrazol-4-yl]carbamoylamino]-3-fluorophenoxy]pyridin-2-yl]acetamide Chemical compound C1=NC(NC(=O)C)=CC(OC=2C=C(F)C(NC(=O)NC=3C(=NN(C=3)C(C)(C)C)C=3C=C4C=NNC4=CC=3)=CC=2)=C1 QALSDSLUGNRFPG-UHFFFAOYSA-N 0.000 claims 1
LODRVSYFUGCWBO-UHFFFAOYSA-N n-[4-[4-[[1-tert-butyl-3-(1h-indazol-5-yl)pyrazol-4-yl]carbamoylamino]phenoxy]pyridin-2-yl]acetamide Chemical compound C1=NC(NC(=O)C)=CC(OC=2C=CC(NC(=O)NC=3C(=NN(C=3)C(C)(C)C)C=3C=C4C=NNC4=CC=3)=CC=2)=C1 LODRVSYFUGCWBO-UHFFFAOYSA-N 0.000 claims 1
COOAYWZQRFXRJW-UHFFFAOYSA-N n-[4-[4-[[1-tert-butyl-3-(2-methyl-3,4-dihydro-1h-isoquinolin-6-yl)pyrazol-4-yl]carbamoylamino]phenoxy]pyridin-2-yl]acetamide Chemical compound C=1C=C2CN(C)CCC2=CC=1C1=NN(C(C)(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC1=CC=NC(NC(C)=O)=C1 COOAYWZQRFXRJW-UHFFFAOYSA-N 0.000 claims 1
IXJCANRWSKNKKX-UHFFFAOYSA-N n-[4-[4-[[1-tert-butyl-3-(2-methyl-3,4-dihydro-1h-isoquinolin-7-yl)pyrazol-4-yl]carbamoylamino]phenoxy]pyridin-2-yl]acetamide Chemical compound C1=C2CN(C)CCC2=CC=C1C1=NN(C(C)(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC1=CC=NC(NC(C)=O)=C1 IXJCANRWSKNKKX-UHFFFAOYSA-N 0.000 claims 1
UDXIJQUIBLQACV-UHFFFAOYSA-N n-[4-[4-[[2-(1,2-benzoxazol-5-yl)-5-propan-2-ylpyrazol-3-yl]carbamoylamino]phenoxy]pyridin-2-yl]acetamide Chemical compound C=1C=C2ON=CC2=CC=1N1N=C(C(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC1=CC=NC(NC(C)=O)=C1 UDXIJQUIBLQACV-UHFFFAOYSA-N 0.000 claims 1
ZHYHDRDFKZPMDO-UHFFFAOYSA-N n-[4-[4-[[2-(1,2-benzoxazol-5-yl)-5-tert-butylpyrazol-3-yl]carbamoylamino]-3-fluorophenoxy]pyridin-2-yl]acetamide Chemical compound C1=NC(NC(=O)C)=CC(OC=2C=C(F)C(NC(=O)NC=3N(N=C(C=3)C(C)(C)C)C=3C=C4C=NOC4=CC=3)=CC=2)=C1 ZHYHDRDFKZPMDO-UHFFFAOYSA-N 0.000 claims 1
XLTUCQKMMYFUMR-UHFFFAOYSA-N n-[4-[4-[[2-(1,3-benzothiazol-5-yl)-5-propan-2-ylpyrazol-3-yl]carbamoylamino]-3-fluorophenoxy]pyridin-2-yl]acetamide Chemical compound C=1C=C2SC=NC2=CC=1N1N=C(C(C)C)C=C1NC(=O)NC(C(=C1)F)=CC=C1OC1=CC=NC(NC(C)=O)=C1 XLTUCQKMMYFUMR-UHFFFAOYSA-N 0.000 claims 1
YSCZPKFWKLXDSE-UHFFFAOYSA-N n-[4-[4-[[2-(1,3-benzothiazol-5-yl)-5-propan-2-ylpyrazol-3-yl]carbamoylamino]phenoxy]pyridin-2-yl]acetamide Chemical compound C=1C=C2SC=NC2=CC=1N1N=C(C(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC1=CC=NC(NC(C)=O)=C1 YSCZPKFWKLXDSE-UHFFFAOYSA-N 0.000 claims 1
FYTRBWLFSUSHBB-UHFFFAOYSA-N n-[4-[4-[[2-(1,3-benzothiazol-5-yl)-5-tert-butylpyrazol-3-yl]carbamoylamino]-3-fluorophenoxy]pyridin-2-yl]acetamide Chemical compound C1=NC(NC(=O)C)=CC(OC=2C=C(F)C(NC(=O)NC=3N(N=C(C=3)C(C)(C)C)C=3C=C4N=CSC4=CC=3)=CC=2)=C1 FYTRBWLFSUSHBB-UHFFFAOYSA-N 0.000 claims 1
ATNRDDMPPLGEJI-UHFFFAOYSA-N n-[4-[4-[[2-(1,3-benzoxazol-5-yl)-5-propan-2-ylpyrazol-3-yl]carbamoylamino]-3-fluorophenoxy]pyridin-2-yl]acetamide Chemical compound C=1C=C2OC=NC2=CC=1N1N=C(C(C)C)C=C1NC(=O)NC(C(=C1)F)=CC=C1OC1=CC=NC(NC(C)=O)=C1 ATNRDDMPPLGEJI-UHFFFAOYSA-N 0.000 claims 1
SOEJEOFXACUXHJ-UHFFFAOYSA-N n-[4-[4-[[2-(1,3-benzoxazol-5-yl)-5-tert-butylpyrazol-3-yl]carbamoylamino]-3-fluorophenoxy]pyridin-2-yl]acetamide Chemical compound C1=NC(NC(=O)C)=CC(OC=2C=C(F)C(NC(=O)NC=3N(N=C(C=3)C(C)(C)C)C=3C=C4N=COC4=CC=3)=CC=2)=C1 SOEJEOFXACUXHJ-UHFFFAOYSA-N 0.000 claims 1
OJABKABYYFRYCE-UHFFFAOYSA-N n-[4-[4-[[2-(1,3-benzoxazol-5-yl)-5-tert-butylpyrazol-3-yl]carbamoylamino]phenoxy]pyridin-2-yl]acetamide Chemical compound C1=NC(NC(=O)C)=CC(OC=2C=CC(NC(=O)NC=3N(N=C(C=3)C(C)(C)C)C=3C=C4N=COC4=CC=3)=CC=2)=C1 OJABKABYYFRYCE-UHFFFAOYSA-N 0.000 claims 1
OWIAKGFYEAJDJP-UHFFFAOYSA-N n-[4-[4-[[2-(2-methyl-3,4-dihydro-1h-isoquinolin-7-yl)-5-propan-2-ylpyrazol-3-yl]carbamoylamino]phenoxy]pyridin-2-yl]acetamide Chemical compound C=1C=C2CCN(C)CC2=CC=1N1N=C(C(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC1=CC=NC(NC(C)=O)=C1 OWIAKGFYEAJDJP-UHFFFAOYSA-N 0.000 claims 1
OMHNLYABRDBWJK-UHFFFAOYSA-N n-[4-[4-[[2-(3h-benzimidazol-5-yl)-5-propan-2-ylpyrazol-3-yl]carbamoylamino]phenoxy]pyridin-2-yl]acetamide Chemical compound C=1C=C2NC=NC2=CC=1N1N=C(C(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC1=CC=NC(NC(C)=O)=C1 OMHNLYABRDBWJK-UHFFFAOYSA-N 0.000 claims 1
FRYVQRFUFPFCND-UHFFFAOYSA-N n-[4-[4-[[2-(3h-benzimidazol-5-yl)-5-tert-butylpyrazol-3-yl]carbamoylamino]-3-fluorophenoxy]pyridin-2-yl]acetamide Chemical compound C1=NC(NC(=O)C)=CC(OC=2C=C(F)C(NC(=O)NC=3N(N=C(C=3)C(C)(C)C)C=3C=C4N=CNC4=CC=3)=CC=2)=C1 FRYVQRFUFPFCND-UHFFFAOYSA-N 0.000 claims 1
XETOBZHIOLGMIA-UHFFFAOYSA-N n-[4-[4-[[3-(1,2-benzoxazol-5-yl)-1-propan-2-ylpyrazol-4-yl]carbamoylamino]-3-fluorophenoxy]pyridin-2-yl]acetamide Chemical compound C=1C=C2ON=CC2=CC=1C1=NN(C(C)C)C=C1NC(=O)NC(C(=C1)F)=CC=C1OC1=CC=NC(NC(C)=O)=C1 XETOBZHIOLGMIA-UHFFFAOYSA-N 0.000 claims 1
FQCIBDYYTOVXOJ-UHFFFAOYSA-N n-[4-[4-[[3-(1,2-benzoxazol-5-yl)-1-propan-2-ylpyrazol-4-yl]carbamoylamino]phenoxy]pyridin-2-yl]acetamide Chemical compound C=1C=C2ON=CC2=CC=1C1=NN(C(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC1=CC=NC(NC(C)=O)=C1 FQCIBDYYTOVXOJ-UHFFFAOYSA-N 0.000 claims 1
QXCLHKYNCXMWMW-UHFFFAOYSA-N n-[4-[4-[[3-(1,2-benzoxazol-5-yl)-1-tert-butylpyrazol-4-yl]carbamoylamino]phenoxy]pyridin-2-yl]acetamide Chemical compound C1=NC(NC(=O)C)=CC(OC=2C=CC(NC(=O)NC=3C(=NN(C=3)C(C)(C)C)C=3C=C4C=NOC4=CC=3)=CC=2)=C1 QXCLHKYNCXMWMW-UHFFFAOYSA-N 0.000 claims 1
VYGUDRAGTUMIKJ-UHFFFAOYSA-N n-[4-[4-[[3-(1,3-benzothiazol-5-yl)-1-propan-2-ylpyrazol-4-yl]carbamoylamino]-3-fluorophenoxy]pyridin-2-yl]acetamide Chemical compound C=1C=C2SC=NC2=CC=1C1=NN(C(C)C)C=C1NC(=O)NC(C(=C1)F)=CC=C1OC1=CC=NC(NC(C)=O)=C1 VYGUDRAGTUMIKJ-UHFFFAOYSA-N 0.000 claims 1
ZRJRNKJZYBUZMA-UHFFFAOYSA-N n-[4-[4-[[3-(1,3-benzothiazol-5-yl)-1-tert-butylpyrazol-4-yl]carbamoylamino]-3-fluorophenoxy]pyridin-2-yl]acetamide Chemical compound C1=NC(NC(=O)C)=CC(OC=2C=C(F)C(NC(=O)NC=3C(=NN(C=3)C(C)(C)C)C=3C=C4N=CSC4=CC=3)=CC=2)=C1 ZRJRNKJZYBUZMA-UHFFFAOYSA-N 0.000 claims 1
FYBGZHBMCGRPTF-UHFFFAOYSA-N n-[4-[4-[[3-(1,3-benzothiazol-5-yl)-1-tert-butylpyrazol-4-yl]carbamoylamino]phenoxy]pyridin-2-yl]acetamide Chemical compound C1=NC(NC(=O)C)=CC(OC=2C=CC(NC(=O)NC=3C(=NN(C=3)C(C)(C)C)C=3C=C4N=CSC4=CC=3)=CC=2)=C1 FYBGZHBMCGRPTF-UHFFFAOYSA-N 0.000 claims 1
TWZXRWKPOKUOMD-UHFFFAOYSA-N n-[4-[4-[[3-(1,3-benzoxazol-5-yl)-1-propan-2-ylpyrazol-4-yl]carbamoylamino]-3-fluorophenoxy]pyridin-2-yl]acetamide Chemical compound C=1C=C2OC=NC2=CC=1C1=NN(C(C)C)C=C1NC(=O)NC(C(=C1)F)=CC=C1OC1=CC=NC(NC(C)=O)=C1 TWZXRWKPOKUOMD-UHFFFAOYSA-N 0.000 claims 1
LIRXRZKKNHKCIY-UHFFFAOYSA-N n-[4-[4-[[3-(1,3-benzoxazol-5-yl)-1-propan-2-ylpyrazol-4-yl]carbamoylamino]phenoxy]pyridin-2-yl]acetamide Chemical compound C=1C=C2OC=NC2=CC=1C1=NN(C(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC1=CC=NC(NC(C)=O)=C1 LIRXRZKKNHKCIY-UHFFFAOYSA-N 0.000 claims 1
OZNYRXRUOFHLCF-UHFFFAOYSA-N n-[4-[4-[[3-(1,3-benzoxazol-5-yl)-1-tert-butylpyrazol-4-yl]carbamoylamino]-3-fluorophenoxy]pyridin-2-yl]acetamide Chemical compound C1=NC(NC(=O)C)=CC(OC=2C=C(F)C(NC(=O)NC=3C(=NN(C=3)C(C)(C)C)C=3C=C4N=COC4=CC=3)=CC=2)=C1 OZNYRXRUOFHLCF-UHFFFAOYSA-N 0.000 claims 1
CQVXRXACTXZIHL-UHFFFAOYSA-N n-[4-[4-[[3-(1,3-benzoxazol-5-yl)-1-tert-butylpyrazol-4-yl]carbamoylamino]phenoxy]pyridin-2-yl]acetamide Chemical compound C1=NC(NC(=O)C)=CC(OC=2C=CC(NC(=O)NC=3C(=NN(C=3)C(C)(C)C)C=3C=C4N=COC4=CC=3)=CC=2)=C1 CQVXRXACTXZIHL-UHFFFAOYSA-N 0.000 claims 1
GXIKXXFWOGWIJA-UHFFFAOYSA-N n-[4-[4-[[3-(2-methyl-3,4-dihydro-1h-isoquinolin-7-yl)-1-propan-2-ylpyrazol-4-yl]carbamoylamino]phenoxy]pyridin-2-yl]acetamide Chemical compound C=1C=C2CCN(C)CC2=CC=1C1=NN(C(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC1=CC=NC(NC(C)=O)=C1 GXIKXXFWOGWIJA-UHFFFAOYSA-N 0.000 claims 1
NRHUZERXVBNHNY-UHFFFAOYSA-N n-[4-[4-[[3-(3h-benzimidazol-5-yl)-1-propan-2-ylpyrazol-4-yl]carbamoylamino]phenoxy]pyridin-2-yl]acetamide Chemical compound C=1C=C2NC=NC2=CC=1C1=NN(C(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC1=CC=NC(NC(C)=O)=C1 NRHUZERXVBNHNY-UHFFFAOYSA-N 0.000 claims 1
CZESKFBIGDXGMQ-UHFFFAOYSA-N n-[4-[4-[[3-(3h-benzimidazol-5-yl)-1-tert-butylpyrazol-4-yl]carbamoylamino]-3-fluorophenoxy]pyridin-2-yl]acetamide Chemical compound C1=NC(NC(=O)C)=CC(OC=2C=C(F)C(NC(=O)NC=3C(=NN(C=3)C(C)(C)C)C=3C=C4N=CNC4=CC=3)=CC=2)=C1 CZESKFBIGDXGMQ-UHFFFAOYSA-N 0.000 claims 1
NEYKKNREFDZAOM-UHFFFAOYSA-N n-[4-[4-[[3-(3h-benzimidazol-5-yl)-1-tert-butylpyrazol-4-yl]carbamoylamino]phenoxy]pyridin-2-yl]acetamide Chemical compound C1=NC(NC(=O)C)=CC(OC=2C=CC(NC(=O)NC=3C(=NN(C=3)C(C)(C)C)C=3C=C4N=CNC4=CC=3)=CC=2)=C1 NEYKKNREFDZAOM-UHFFFAOYSA-N 0.000 claims 1
WIXUCEYNGHZAHL-UHFFFAOYSA-N n-[4-[4-[[5-tert-butyl-2-(1h-indazol-5-yl)pyrazol-3-yl]carbamoylamino]phenoxy]pyridin-2-yl]acetamide Chemical compound C1=NC(NC(=O)C)=CC(OC=2C=CC(NC(=O)NC=3N(N=C(C=3)C(C)(C)C)C=3C=C4C=NNC4=CC=3)=CC=2)=C1 WIXUCEYNGHZAHL-UHFFFAOYSA-N 0.000 claims 1
VVZZJCLCVSDUGB-UHFFFAOYSA-N n-[4-[4-[[5-tert-butyl-2-(2-methyl-3,4-dihydro-1h-isoquinolin-6-yl)pyrazol-3-yl]carbamoylamino]-3-fluorophenoxy]pyridin-2-yl]acetamide Chemical compound C=1C=C2CN(C)CCC2=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)NC(C(=C1)F)=CC=C1OC1=CC=NC(NC(C)=O)=C1 VVZZJCLCVSDUGB-UHFFFAOYSA-N 0.000 claims 1
MSCUWILOFLECRZ-UHFFFAOYSA-N n-[4-[4-[[5-tert-butyl-2-(2-methyl-3,4-dihydro-1h-isoquinolin-6-yl)pyrazol-3-yl]carbamoylamino]phenoxy]pyridin-2-yl]acetamide Chemical compound C=1C=C2CN(C)CCC2=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC1=CC=NC(NC(C)=O)=C1 MSCUWILOFLECRZ-UHFFFAOYSA-N 0.000 claims 1
WDFWCXPRSDEGSF-UHFFFAOYSA-N n-[4-[4-[[5-tert-butyl-2-(2-methyl-3,4-dihydro-1h-isoquinolin-7-yl)pyrazol-3-yl]carbamoylamino]-3-fluorophenoxy]pyridin-2-yl]acetamide Chemical compound C1=C2CN(C)CCC2=CC=C1N1N=C(C(C)(C)C)C=C1NC(=O)NC(C(=C1)F)=CC=C1OC1=CC=NC(NC(C)=O)=C1 WDFWCXPRSDEGSF-UHFFFAOYSA-N 0.000 claims 1
JBJAVASIFMNLBA-UHFFFAOYSA-N n-[4-[4-[[5-tert-butyl-2-(2-methyl-3,4-dihydro-1h-isoquinolin-7-yl)pyrazol-3-yl]carbamoylamino]phenoxy]pyridin-2-yl]acetamide Chemical compound C1=C2CN(C)CCC2=CC=C1N1N=C(C(C)(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC1=CC=NC(NC(C)=O)=C1 JBJAVASIFMNLBA-UHFFFAOYSA-N 0.000 claims 1
DYWJWXRBAHMFEA-UHFFFAOYSA-N n-methyl-4-[4-[(1-propan-2-yl-3-quinolin-6-ylpyrazol-4-yl)carbamoylamino]phenoxy]pyridine-2-carboxamide Chemical compound C1=NC(C(=O)NC)=CC(OC=2C=CC(NC(=O)NC=3C(=NN(C=3)C(C)C)C=3C=C4C=CC=NC4=CC=3)=CC=2)=C1 DYWJWXRBAHMFEA-UHFFFAOYSA-N 0.000 claims 1
GJLPPHIJSDVAPW-UHFFFAOYSA-N n-methyl-4-[4-[[1-propan-2-yl-3-(1,2,3,4-tetrahydroisoquinolin-6-yl)pyrazol-4-yl]carbamoylamino]phenoxy]pyridine-2-carboxamide Chemical compound C1=NC(C(=O)NC)=CC(OC=2C=CC(NC(=O)NC=3C(=NN(C=3)C(C)C)C=3C=C4CCNCC4=CC=3)=CC=2)=C1 GJLPPHIJSDVAPW-UHFFFAOYSA-N 0.000 claims 1
NHWGOSGPADKELV-UHFFFAOYSA-N n-methyl-4-[4-[[2-(2-methyl-3,4-dihydro-1h-isoquinolin-6-yl)-5-propan-2-ylpyrazol-3-yl]carbamoylamino]phenoxy]pyridine-2-carboxamide Chemical compound C1=NC(C(=O)NC)=CC(OC=2C=CC(NC(=O)NC=3N(N=C(C=3)C(C)C)C=3C=C4CCN(C)CC4=CC=3)=CC=2)=C1 NHWGOSGPADKELV-UHFFFAOYSA-N 0.000 claims 1
BQCYQLSIHNDAQK-UHFFFAOYSA-N n-methyl-4-[4-[[2-(2-methyl-3,4-dihydro-1h-isoquinolin-7-yl)-5-propan-2-ylpyrazol-3-yl]carbamoylamino]phenoxy]pyridine-2-carboxamide Chemical compound C1=NC(C(=O)NC)=CC(OC=2C=CC(NC(=O)NC=3N(N=C(C=3)C(C)C)C=3C=C4CN(C)CCC4=CC=3)=CC=2)=C1 BQCYQLSIHNDAQK-UHFFFAOYSA-N 0.000 claims 1
GIVINHJCYOPJLX-UHFFFAOYSA-N n-methyl-4-[4-[[3-(2-methyl-3,4-dihydro-1h-isoquinolin-7-yl)-1-propan-2-ylpyrazol-4-yl]carbamoylamino]phenoxy]pyridine-2-carboxamide Chemical compound C1=NC(C(=O)NC)=CC(OC=2C=CC(NC(=O)NC=3C(=NN(C=3)C(C)C)C=3C=C4CN(C)CCC4=CC=3)=CC=2)=C1 GIVINHJCYOPJLX-UHFFFAOYSA-N 0.000 claims 1
125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 claims 1
239000008194 pharmaceutical composition Substances 0.000 claims 1
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125000004528 pyrimidin-5-yl group Chemical group N1=CN=CC(=C1)* 0.000 claims 1
JWVCLYRUEFBMGU-UHFFFAOYSA-N quinazoline Chemical compound N1=CN=CC2=CC=CC=C21 JWVCLYRUEFBMGU-UHFFFAOYSA-N 0.000 claims 1
239000003381 stabilizer Substances 0.000 claims 1
125000005329 tetralinyl group Chemical group C1(CCCC2=CC=CC=C12)* 0.000 claims 1
125000004496 thiazol-5-yl group Chemical group S1C=NC=C1* 0.000 claims 1
0 CC(CC(C)(C)CCC=C[C@](C)C1C(C)C(C)(C*=C)C1)C1C(C)CCC1C Chemical compound CC(CC(C)(C)CCC=C[C@](C)C1C(C)C(C)(C*=C)C1)C1C(C)CCC1C 0.000 description 28
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JP2007548595A 2004-12-23 2005-12-23 酵素モジュレータ及び治療 Expired - Fee Related JP5197016B2 (ja)