JP2006520805A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2006520805A5 JP2006520805A5 JP2006507472A JP2006507472A JP2006520805A5 JP 2006520805 A5 JP2006520805 A5 JP 2006520805A5 JP 2006507472 A JP2006507472 A JP 2006507472A JP 2006507472 A JP2006507472 A JP 2006507472A JP 2006520805 A5 JP2006520805 A5 JP 2006520805A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- optionally substituted
- ylmethoxy
- phenyl
- unsubstituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- -1 substituted Chemical group 0.000 claims 321
- 150000001875 compounds Chemical class 0.000 claims 54
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 52
- 125000000623 heterocyclic group Chemical group 0.000 claims 44
- 125000001424 substituent group Chemical group 0.000 claims 27
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 24
- 125000000217 alkyl group Chemical group 0.000 claims 22
- 125000004093 cyano group Chemical group *C#N 0.000 claims 20
- 125000001475 halogen functional group Chemical group 0.000 claims 20
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 15
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 13
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 13
- 125000003418 alkyl amino alkoxy group Chemical group 0.000 claims 12
- 229910052760 oxygen Inorganic materials 0.000 claims 12
- 125000005346 substituted cycloalkyl group Chemical group 0.000 claims 12
- 125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 claims 11
- 239000003814 drug Substances 0.000 claims 11
- 229910052739 hydrogen Inorganic materials 0.000 claims 9
- 125000001041 indolyl group Chemical group 0.000 claims 9
- 125000000904 isoindolyl group Chemical group C=1(NC=C2C=CC=CC12)* 0.000 claims 9
- 125000004043 oxo group Chemical group O=* 0.000 claims 9
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 8
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 8
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 claims 8
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 8
- 125000005956 isoquinolyl group Chemical group 0.000 claims 8
- 125000006340 pentafluoro ethyl group Chemical group FC(F)(F)C(F)(F)* 0.000 claims 8
- 125000002294 quinazolinyl group Chemical group N1=C(N=CC2=CC=CC=C12)* 0.000 claims 8
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 8
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 7
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 7
- 229910052799 carbon Inorganic materials 0.000 claims 7
- 238000004519 manufacturing process Methods 0.000 claims 7
- 125000004076 pyridyl group Chemical group 0.000 claims 7
- 229910052717 sulfur Inorganic materials 0.000 claims 7
- 125000003118 aryl group Chemical group 0.000 claims 6
- 125000001188 haloalkyl group Chemical group 0.000 claims 6
- 125000003226 pyrazolyl group Chemical group 0.000 claims 6
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 6
- 125000003354 benzotriazolyl group Chemical group N1N=NC2=C1C=CC=C2* 0.000 claims 5
- 229940079593 drug Drugs 0.000 claims 5
- 125000004415 heterocyclylalkyl group Chemical group 0.000 claims 5
- 125000003392 indanyl group Chemical group C1(CCC2=CC=CC=C12)* 0.000 claims 5
- 125000003453 indazolyl group Chemical group N1N=C(C2=C1C=CC=C2)* 0.000 claims 5
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 5
- 125000001624 naphthyl group Chemical group 0.000 claims 5
- 125000004593 naphthyridinyl group Chemical group N1=C(C=CC2=CC=CN=C12)* 0.000 claims 5
- 229910052757 nitrogen Inorganic materials 0.000 claims 5
- 125000003386 piperidinyl group Chemical group 0.000 claims 5
- 125000002098 pyridazinyl group Chemical group 0.000 claims 5
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 5
- 125000001712 tetrahydronaphthyl group Chemical group C1(CCCC2=CC=CC=C12)* 0.000 claims 5
- 125000001544 thienyl group Chemical group 0.000 claims 5
- 125000001425 triazolyl group Chemical group 0.000 claims 5
- 125000004066 1-hydroxyethyl group Chemical group [H]OC([H])([*])C([H])([H])[H] 0.000 claims 4
- 125000000022 2-aminoethyl group Chemical group [H]C([*])([H])C([H])([H])N([H])[H] 0.000 claims 4
- 125000000954 2-hydroxyethyl group Chemical group [H]C([*])([H])C([H])([H])O[H] 0.000 claims 4
- 125000000278 alkyl amino alkyl group Chemical group 0.000 claims 4
- 125000004103 aminoalkyl group Chemical group 0.000 claims 4
- 125000004202 aminomethyl group Chemical group [H]N([H])C([H])([H])* 0.000 claims 4
- 125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 claims 4
- 125000002047 benzodioxolyl group Chemical group O1OC(C2=C1C=CC=C2)* 0.000 claims 4
- 125000004618 benzofuryl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 claims 4
- 125000001164 benzothiazolyl group Chemical group S1C(=NC2=C1C=CC=C2)* 0.000 claims 4
- 125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 claims 4
- 125000004541 benzoxazolyl group Chemical group O1C(=NC2=C1C=CC=C2)* 0.000 claims 4
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 4
- 125000000753 cycloalkyl group Chemical group 0.000 claims 4
- 125000000842 isoxazolyl group Chemical group 0.000 claims 4
- 125000001160 methoxycarbonyl group Chemical group [H]C([H])([H])OC(*)=O 0.000 claims 4
- 125000004674 methylcarbonyl group Chemical group CC(=O)* 0.000 claims 4
- 125000004170 methylsulfonyl group Chemical group [H]C([H])([H])S(*)(=O)=O 0.000 claims 4
- 125000002757 morpholinyl group Chemical group 0.000 claims 4
- 125000005246 nonafluorobutyl group Chemical group FC(F)(F)C(F)(F)C(F)(F)C(F)(F)* 0.000 claims 4
- 125000003884 phenylalkyl group Chemical group 0.000 claims 4
- 125000004193 piperazinyl group Chemical group 0.000 claims 4
- 125000004527 pyrimidin-4-yl group Chemical group N1=CN=C(C=C1)* 0.000 claims 4
- 125000001113 thiadiazolyl group Chemical group 0.000 claims 4
- 125000000335 thiazolyl group Chemical group 0.000 claims 4
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 3
- 125000004940 pyridazin-4-yl group Chemical group N1=NC=C(C=C1)* 0.000 claims 3
- 125000005493 quinolyl group Chemical group 0.000 claims 3
- 125000004890 (C1-C6) alkylamino group Chemical group 0.000 claims 2
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims 2
- 125000004214 1-pyrrolidinyl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 2
- XTBAPWCYTNCZTO-UHFFFAOYSA-N 1H-isoindolone Natural products C1=CC=C2C(=O)N=CC2=C1 XTBAPWCYTNCZTO-UHFFFAOYSA-N 0.000 claims 2
- 125000003342 alkenyl group Chemical group 0.000 claims 2
- 125000000304 alkynyl group Chemical group 0.000 claims 2
- 150000001412 amines Chemical class 0.000 claims 2
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 claims 2
- IOJUPLGTWVMSFF-UHFFFAOYSA-N benzothiazole Chemical compound C1=CC=C2SC=NC2=C1 IOJUPLGTWVMSFF-UHFFFAOYSA-N 0.000 claims 2
- 125000002619 bicyclic group Chemical group 0.000 claims 2
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 2
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- 125000006583 (C1-C3) haloalkyl group Chemical group 0.000 claims 1
- 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 claims 1
- YBYIRNPNPLQARY-UHFFFAOYSA-N 1H-indene Natural products C1=CC=C2CC=CC2=C1 YBYIRNPNPLQARY-UHFFFAOYSA-N 0.000 claims 1
- WGONGMOZFNXPIC-UHFFFAOYSA-N 4-[2-[4-chloro-3-[(4-methylpiperazin-1-yl)methyl]anilino]-1-methylbenzimidazol-5-yl]oxy-n-methylpyridine-2-carboxamide Chemical compound C1=NC(C(=O)NC)=CC(OC=2C=C3N=C(NC=4C=C(CN5CCN(C)CC5)C(Cl)=CC=4)N(C)C3=CC=2)=C1 WGONGMOZFNXPIC-UHFFFAOYSA-N 0.000 claims 1
- ZKSUUBLMUIKQJD-UHFFFAOYSA-N 4-[[2-[3-[2-(dimethylamino)ethoxy]-4-(trifluoromethyl)anilino]-3h-benzimidazol-5-yl]oxy]-n-methylpyridine-2-carboxamide Chemical compound C1=NC(C(=O)NC)=CC(OC=2C=C3N=C(NC=4C=C(OCCN(C)C)C(=CC=4)C(F)(F)F)NC3=CC=2)=C1 ZKSUUBLMUIKQJD-UHFFFAOYSA-N 0.000 claims 1
- BTZADJMCMGCPTD-UHFFFAOYSA-N 4-[[2-[4-chloro-3-(piperidin-4-ylmethoxy)anilino]-1,3-benzoxazol-5-yl]oxy]-n-methylpyridine-2-carboxamide Chemical compound C1=NC(C(=O)NC)=CC(OC=2C=C3N=C(NC=4C=C(OCC5CCNCC5)C(Cl)=CC=4)OC3=CC=2)=C1 BTZADJMCMGCPTD-UHFFFAOYSA-N 0.000 claims 1
- ONCNFHJNNVYNMM-UHFFFAOYSA-N 4-[[2-[4-chloro-3-[(1-methylpiperidin-4-yl)methoxy]anilino]-1,3-benzoxazol-5-yl]oxy]-n-methylpyridine-2-carboxamide Chemical compound C1=NC(C(=O)NC)=CC(OC=2C=C3N=C(NC=4C=C(OCC5CCN(C)CC5)C(Cl)=CC=4)OC3=CC=2)=C1 ONCNFHJNNVYNMM-UHFFFAOYSA-N 0.000 claims 1
- KMNCFOUKJYOZIF-UHFFFAOYSA-N 4-[[2-[4-chloro-3-[(1-methylpyrrolidin-2-yl)methoxy]anilino]-1,3-benzoxazol-5-yl]oxy]-n-methylpyridine-2-carboxamide Chemical compound C1=NC(C(=O)NC)=CC(OC=2C=C3N=C(NC=4C=C(OCC5N(CCC5)C)C(Cl)=CC=4)OC3=CC=2)=C1 KMNCFOUKJYOZIF-UHFFFAOYSA-N 0.000 claims 1
- VAZZXEJSCUQVTN-UHFFFAOYSA-N 4-[[2-[4-chloro-3-[(1-propan-2-ylpiperidin-4-yl)methoxy]anilino]-1,3-benzoxazol-5-yl]oxy]-n-methylpyridine-2-carboxamide Chemical compound C1=NC(C(=O)NC)=CC(OC=2C=C3N=C(NC=4C=C(OCC5CCN(CC5)C(C)C)C(Cl)=CC=4)OC3=CC=2)=C1 VAZZXEJSCUQVTN-UHFFFAOYSA-N 0.000 claims 1
- QLGYPFBXPCFQHJ-UHFFFAOYSA-N 4-[[2-[4-chloro-3-[(4-methylpiperazin-1-yl)methyl]anilino]-1,3-benzoxazol-5-yl]oxy]-n-methylpyridine-2-carboxamide Chemical compound C1=NC(C(=O)NC)=CC(OC=2C=C3N=C(NC=4C=C(CN5CCN(C)CC5)C(Cl)=CC=4)OC3=CC=2)=C1 QLGYPFBXPCFQHJ-UHFFFAOYSA-N 0.000 claims 1
- HYVFNIQDPPNFIH-UHFFFAOYSA-N 4-[[2-[4-chloro-3-[2-(dimethylamino)ethoxy]anilino]-1,3-benzoxazol-5-yl]oxy]-n-methylpyridine-2-carboxamide Chemical compound C1=NC(C(=O)NC)=CC(OC=2C=C3N=C(NC=4C=C(OCCN(C)C)C(Cl)=CC=4)OC3=CC=2)=C1 HYVFNIQDPPNFIH-UHFFFAOYSA-N 0.000 claims 1
- PPPJFYDGNJWIOT-INIZCTEOSA-N 4-[[2-[4-chloro-3-[[(2s)-1-methylpyrrolidin-2-yl]methoxy]anilino]-1,3-benzoxazol-5-yl]oxy]pyridine-2-carboxamide Chemical compound CN1CCC[C@H]1COC1=CC(NC=2OC3=CC=C(OC=4C=C(N=CC=4)C(N)=O)C=C3N=2)=CC=C1Cl PPPJFYDGNJWIOT-INIZCTEOSA-N 0.000 claims 1
- IEAKVOACBVHQHG-IBGZPJMESA-N 4-[[2-[4-chloro-3-[[(2s)-1-propan-2-ylpyrrolidin-2-yl]methoxy]anilino]-1,3-benzoxazol-5-yl]oxy]-n-methylpyridine-2-carboxamide Chemical compound C1=NC(C(=O)NC)=CC(OC=2C=C3N=C(NC=4C=C(OC[C@H]5N(CCC5)C(C)C)C(Cl)=CC=4)OC3=CC=2)=C1 IEAKVOACBVHQHG-IBGZPJMESA-N 0.000 claims 1
- NBAJZYVYCOJEQZ-UHFFFAOYSA-N 4-[[2-[4-chloro-3-[[4-[2-(dimethylamino)ethyl]piperazin-1-yl]methyl]anilino]-1,3-benzoxazol-5-yl]oxy]-n-methylpyridine-2-carboxamide Chemical compound C1=NC(C(=O)NC)=CC(OC=2C=C3N=C(NC=4C=C(CN5CCN(CCN(C)C)CC5)C(Cl)=CC=4)OC3=CC=2)=C1 NBAJZYVYCOJEQZ-UHFFFAOYSA-N 0.000 claims 1
- ABWJVVCPMHFSTN-UHFFFAOYSA-N 4-[[7-chloro-2-[4-chloro-3-[(4-methylpiperazin-1-yl)methyl]anilino]-1,3-benzoxazol-5-yl]oxy]-n-methylpyridine-2-carboxamide Chemical compound C1=NC(C(=O)NC)=CC(OC=2C=C3N=C(NC=4C=C(CN5CCN(C)CC5)C(Cl)=CC=4)OC3=C(Cl)C=2)=C1 ABWJVVCPMHFSTN-UHFFFAOYSA-N 0.000 claims 1
- JPWMAVZTWDLRIZ-UHFFFAOYSA-N 7-chloro-n-[4-chloro-3-[(4-methylpiperazin-1-yl)methyl]phenyl]-5-quinolin-4-yloxy-1,3-benzoxazol-2-amine Chemical compound C1CN(C)CCN1CC1=CC(NC=2OC3=C(Cl)C=C(OC=4C5=CC=CC=C5N=CC=4)C=C3N=2)=CC=C1Cl JPWMAVZTWDLRIZ-UHFFFAOYSA-N 0.000 claims 1
- 206010012689 Diabetic retinopathy Diseases 0.000 claims 1
- 102000014150 Interferons Human genes 0.000 claims 1
- 108010050904 Interferons Proteins 0.000 claims 1
- PEEHTFAAVSWFBL-UHFFFAOYSA-N Maleimide Chemical compound O=C1NC(=O)C=C1 PEEHTFAAVSWFBL-UHFFFAOYSA-N 0.000 claims 1
- 241001024304 Mino Species 0.000 claims 1
- 239000002168 alkylating agent Substances 0.000 claims 1
- 229940100198 alkylating agent Drugs 0.000 claims 1
- 125000005466 alkylenyl group Chemical group 0.000 claims 1
- 230000033115 angiogenesis Effects 0.000 claims 1
- 230000000340 anti-metabolite Effects 0.000 claims 1
- 239000002256 antimetabolite Substances 0.000 claims 1
- 229940100197 antimetabolite Drugs 0.000 claims 1
- 125000003710 aryl alkyl group Chemical group 0.000 claims 1
- 230000003115 biocidal effect Effects 0.000 claims 1
- 230000017531 blood circulation Effects 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 claims 1
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 1
- 230000007423 decrease Effects 0.000 claims 1
- 125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 125000002541 furyl group Chemical group 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 229940088597 hormone Drugs 0.000 claims 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 1
- 125000002883 imidazolyl group Chemical group 0.000 claims 1
- 230000001900 immune effect Effects 0.000 claims 1
- 125000003454 indenyl group Chemical group C1(C=CC2=CC=CC=C12)* 0.000 claims 1
- 229940079322 interferon Drugs 0.000 claims 1
- 125000002183 isoquinolinyl group Chemical group C1(=NC=CC2=CC=CC=C12)* 0.000 claims 1
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims 1
- DEYZENHJMHXQGD-UHFFFAOYSA-N n-(4-chlorophenyl)-6-(6,7-dimethoxyquinazolin-4-yl)oxy-1h-benzimidazol-2-amine Chemical compound C=12C=C(OC)C(OC)=CC2=NC=NC=1OC(C=C1N=2)=CC=C1NC=2NC1=CC=C(Cl)C=C1 DEYZENHJMHXQGD-UHFFFAOYSA-N 0.000 claims 1
- CWZBMSLLFXVAJC-UHFFFAOYSA-N n-[3-[(1-methylpyrrolidin-2-yl)methoxy]-4-(trifluoromethyl)phenyl]-5-quinolin-4-yloxy-1,3-benzoxazol-2-amine Chemical compound CN1CCCC1COC1=CC(NC=2OC3=CC=C(OC=4C5=CC=CC=C5N=CC=4)C=C3N=2)=CC=C1C(F)(F)F CWZBMSLLFXVAJC-UHFFFAOYSA-N 0.000 claims 1
- WATHVYRKWVIPDZ-UHFFFAOYSA-N n-[3-[(1-methylpyrrolidin-2-yl)methoxy]-4-(trifluoromethyl)phenyl]-6-quinolin-4-yloxy-1h-benzimidazol-2-amine Chemical compound CN1CCCC1COC1=CC(NC=2NC3=CC=C(OC=4C5=CC=CC=C5N=CC=4)C=C3N=2)=CC=C1C(F)(F)F WATHVYRKWVIPDZ-UHFFFAOYSA-N 0.000 claims 1
- LKRNZKIENIKMKS-UHFFFAOYSA-N n-[4-chloro-3-[(1-methylpyrrolidin-2-yl)methoxy]phenyl]-5-(6,7-dimethoxyquinazolin-4-yl)oxy-1,3-benzoxazol-2-amine Chemical compound C=12C=C(OC)C(OC)=CC2=NC=NC=1OC(C=C1N=2)=CC=C1OC=2NC(C=1)=CC=C(Cl)C=1OCC1CCCN1C LKRNZKIENIKMKS-UHFFFAOYSA-N 0.000 claims 1
- NRUKDYLILMOFJD-UHFFFAOYSA-N n-[4-chloro-3-[(1-methylpyrrolidin-2-yl)methoxy]phenyl]-5-(6,7-dimethoxyquinolin-4-yl)oxy-1,3-benzoxazol-2-amine Chemical compound C=12C=C(OC)C(OC)=CC2=NC=CC=1OC(C=C1N=2)=CC=C1OC=2NC(C=1)=CC=C(Cl)C=1OCC1CCCN1C NRUKDYLILMOFJD-UHFFFAOYSA-N 0.000 claims 1
- CCNMBKXRBDXKJO-UHFFFAOYSA-N n-[4-chloro-3-[(1-methylpyrrolidin-2-yl)methoxy]phenyl]-5-quinolin-4-yloxy-1,3-benzoxazol-2-amine Chemical compound CN1CCCC1COC1=CC(NC=2OC3=CC=C(OC=4C5=CC=CC=C5N=CC=4)C=C3N=2)=CC=C1Cl CCNMBKXRBDXKJO-UHFFFAOYSA-N 0.000 claims 1
- AURLMJBXLIAZKM-UHFFFAOYSA-N n-[4-chloro-3-[(1-propan-2-ylpyrrolidin-2-yl)methoxy]phenyl]-5-(1h-pyrrolo[2,3-b]pyridin-4-yloxy)-1,3-benzoxazol-2-amine Chemical compound CC(C)N1CCCC1COC1=CC(NC=2OC3=CC=C(OC=4C=5C=CNC=5N=CC=4)C=C3N=2)=CC=C1Cl AURLMJBXLIAZKM-UHFFFAOYSA-N 0.000 claims 1
- YCFIPAIIPRUSQE-UHFFFAOYSA-N n-[4-chloro-3-[(4-methylpiperazin-1-yl)methyl]phenyl]-5-(1h-pyrrolo[2,3-b]pyridin-4-yloxy)-1,3-benzoxazol-2-amine Chemical compound C1CN(C)CCN1CC1=CC(NC=2OC3=CC=C(OC=4C=5C=CNC=5N=CC=4)C=C3N=2)=CC=C1Cl YCFIPAIIPRUSQE-UHFFFAOYSA-N 0.000 claims 1
- OGLAJZUWRJDROE-UHFFFAOYSA-N n-[4-chloro-3-[(4-methylpiperazin-1-yl)methyl]phenyl]-5-(6,7-dimethoxyquinolin-4-yl)oxy-1,3-benzoxazol-2-amine Chemical compound C=12C=C(OC)C(OC)=CC2=NC=CC=1OC(C=C1N=2)=CC=C1OC=2NC(C=1)=CC=C(Cl)C=1CN1CCN(C)CC1 OGLAJZUWRJDROE-UHFFFAOYSA-N 0.000 claims 1
- GZXULZRBYRVYLK-UHFFFAOYSA-N n-[4-chloro-3-[(4-methylpiperazin-1-yl)methyl]phenyl]-6-(6,7-dimethoxyquinolin-4-yl)oxy-1h-benzimidazol-2-amine Chemical compound C=12C=C(OC)C(OC)=CC2=NC=CC=1OC(C=C1N=2)=CC=C1NC=2NC(C=1)=CC=C(Cl)C=1CN1CCN(C)CC1 GZXULZRBYRVYLK-UHFFFAOYSA-N 0.000 claims 1
- NVFBMDKKXKOASI-UHFFFAOYSA-N n-[4-chloro-3-[(4-methylpiperazin-1-yl)methyl]phenyl]-6-quinolin-4-yloxy-1h-benzimidazol-2-amine Chemical compound C1CN(C)CCN1CC1=CC(NC=2NC3=CC=C(OC=4C5=CC=CC=C5N=CC=4)C=C3N=2)=CC=C1Cl NVFBMDKKXKOASI-UHFFFAOYSA-N 0.000 claims 1
- BIJITFOSDDPLRR-KRWDZBQOSA-N n-[4-chloro-3-[[(2s)-1-methylpyrrolidin-2-yl]methoxy]phenyl]-5-(1h-pyrrolo[2,3-b]pyridin-4-yloxy)-1,3-benzoxazol-2-amine Chemical compound CN1CCC[C@H]1COC1=CC(NC=2OC3=CC=C(OC=4C=5C=CNC=5N=CC=4)C=C3N=2)=CC=C1Cl BIJITFOSDDPLRR-KRWDZBQOSA-N 0.000 claims 1
- CZGSISQHBYWGGG-KRWDZBQOSA-N n-[4-chloro-3-[[(2s)-1-methylpyrrolidin-2-yl]methoxy]phenyl]-5-[2-(methylamino)pyridin-4-yl]oxy-1,3-benzoxazol-2-amine Chemical compound C1=NC(NC)=CC(OC=2C=C3N=C(NC=4C=C(OC[C@H]5N(CCC5)C)C(Cl)=CC=4)OC3=CC=2)=C1 CZGSISQHBYWGGG-KRWDZBQOSA-N 0.000 claims 1
- DZPFHDSAWGBFFX-UHFFFAOYSA-N n-methyl-4-[[2-[3-[(1-methylpyrrolidin-2-yl)methoxy]-4-(1,1,2,2,2-pentafluoroethyl)anilino]-3h-benzimidazol-5-yl]oxy]pyridine-2-carboxamide Chemical compound C1=NC(C(=O)NC)=CC(OC=2C=C3N=C(NC=4C=C(OCC5N(CCC5)C)C(=CC=4)C(F)(F)C(F)(F)F)NC3=CC=2)=C1 DZPFHDSAWGBFFX-UHFFFAOYSA-N 0.000 claims 1
- CNFXCXPJZGOMBX-UHFFFAOYSA-N n-methyl-4-[[2-[3-[(1-methylpyrrolidin-2-yl)methoxy]-4-(trifluoromethyl)anilino]-3h-benzimidazol-5-yl]oxy]pyridine-2-carboxamide Chemical compound C1=NC(C(=O)NC)=CC(OC=2C=C3N=C(NC=4C=C(OCC5N(CCC5)C)C(=CC=4)C(F)(F)F)NC3=CC=2)=C1 CNFXCXPJZGOMBX-UHFFFAOYSA-N 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000002568 propynyl group Chemical group [*]C#CC([H])([H])[H] 0.000 claims 1
- 125000005415 substituted alkoxy group Chemical group 0.000 claims 1
- 125000000547 substituted alkyl group Chemical group 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- 125000004306 triazinyl group Chemical group 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US45669103P | 2003-03-21 | 2003-03-21 | |
| US10/804,915 US7531553B2 (en) | 2003-03-21 | 2004-03-19 | Heterocyclic compounds and methods of use |
| PCT/US2004/008809 WO2004085425A1 (en) | 2003-03-21 | 2004-03-22 | Fused azoles such as 2,5-disubstituted benzimidazoles, benzoxazoles and benzothiazoles as kinase inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006520805A JP2006520805A (ja) | 2006-09-14 |
| JP2006520805A5 true JP2006520805A5 (enExample) | 2007-05-17 |
Family
ID=33101264
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006507472A Withdrawn JP2006520805A (ja) | 2003-03-21 | 2004-03-22 | 複素環式化合物ならびにその使用方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US7531553B2 (enExample) |
| EP (1) | EP1638954A1 (enExample) |
| JP (1) | JP2006520805A (enExample) |
| AU (1) | AU2004223827B2 (enExample) |
| CA (1) | CA2518909A1 (enExample) |
| MX (1) | MXPA05010086A (enExample) |
| WO (1) | WO2004085425A1 (enExample) |
Families Citing this family (104)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8124630B2 (en) | 1999-01-13 | 2012-02-28 | Bayer Healthcare Llc | ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors |
| ATE538794T1 (de) | 1999-01-13 | 2012-01-15 | Bayer Healthcare Llc | Gamma carboxyarylsubstituierte diphenylharnstoffverbindungen als p38 kinasehemmer |
| RU2319693C9 (ru) | 1999-01-13 | 2008-08-20 | Байер Копэрейшн | Производные мочевины (варианты), фармацевтическая композиция (варианты) и способ лечения заболевания, связанного с ростом раковых клеток (варианты) |
| US20030216396A1 (en) | 2002-02-11 | 2003-11-20 | Bayer Corporation | Pyridine, quinoline, and isoquinoline N-oxides as kinase inhibitors |
| US7838541B2 (en) | 2002-02-11 | 2010-11-23 | Bayer Healthcare, Llc | Aryl ureas with angiogenesis inhibiting activity |
| US7071216B2 (en) | 2002-03-29 | 2006-07-04 | Chiron Corporation | Substituted benz-azoles and methods of their use as inhibitors of Raf kinase |
| US8299108B2 (en) * | 2002-03-29 | 2012-10-30 | Novartis Ag | Substituted benzazoles and methods of their use as inhibitors of raf kinase |
| UY28213A1 (es) | 2003-02-28 | 2004-09-30 | Bayer Pharmaceuticals Corp | Nuevos derivados de cianopiridina útiles en el tratamiento de cáncer y otros trastornos. |
| ES2423800T3 (es) * | 2003-03-28 | 2013-09-24 | Novartis Vaccines And Diagnostics, Inc. | Uso de compuestos orgánicos para la inmunopotenciación |
| WO2004113274A2 (en) | 2003-05-20 | 2004-12-29 | Bayer Pharmaceuticals Corporation | Diaryl ureas with kinase inhibiting activity |
| RS52625B (sr) | 2003-07-23 | 2013-06-28 | Bayer Healthcare Llc | Fluoro supstituisana omega-karboksiaril difenil urea za lečenje i prevenciju bolesti i stanja bolesti |
| DE602004021838D1 (de) | 2003-10-16 | 2009-08-13 | Novartis Vaccines & Diagnostic | Substituierte benzazole und ihre verwendung als raf-kinase-hemmer |
| DE10349587A1 (de) * | 2003-10-24 | 2005-05-25 | Merck Patent Gmbh | Benzimidazolylderivate |
| US7714009B2 (en) * | 2003-10-31 | 2010-05-11 | Takeda Pharmaceutical Company Limited | Nitrogen-containing fused heterocyclic compounds |
| WO2005070891A2 (en) | 2004-01-23 | 2005-08-04 | Amgen Inc | Compounds and methods of use |
| WO2005073224A2 (en) * | 2004-01-23 | 2005-08-11 | Amgen Inc | Quinoline quinazoline pyridine and pyrimidine counds and their use in the treatment of inflammation angiogenesis and cancer |
| MEP8409A (en) * | 2004-06-02 | 2011-12-20 | Fused heterocyclic compound | |
| WO2005121125A1 (en) * | 2004-06-09 | 2005-12-22 | Pfizer Inc. | Ether-linked heteroaryl compounds |
| MXPA06014495A (es) * | 2004-06-17 | 2007-03-01 | Cytokinetics Inc | Compuestos, composiciones y metodos. |
| GB0423554D0 (en) * | 2004-10-22 | 2004-11-24 | Cancer Rec Tech Ltd | Therapeutic compounds |
| JP2008521900A (ja) | 2004-11-30 | 2008-06-26 | アムジエン・インコーポレーテツド | キノリン及びキナゾリン類似体並びにがん治療のための医薬としてのその使用 |
| US7514460B2 (en) | 2004-12-22 | 2009-04-07 | 4Sc Ag | Benzazole analogues and uses thereof |
| EP1674467A1 (en) * | 2004-12-22 | 2006-06-28 | 4Sc Ag | 2,5- and 2,6-disubstituted benzazole derivatives useful as protein kinase inhibitors |
| EP1674466A1 (en) * | 2004-12-27 | 2006-06-28 | 4Sc Ag | 2,5- and 2,6-disubstituted benzazole analogues useful as protein kinase inhibitors |
| US7576090B2 (en) | 2004-12-27 | 2009-08-18 | 4Sc Ag | Benzazole analogues and uses thereof |
| WO2006076592A1 (en) | 2005-01-14 | 2006-07-20 | Cgi Pharmaceuticals, Inc. | 1,3 substituted diaryl ureas as modulators of kinase activity |
| US7429608B2 (en) | 2005-01-20 | 2008-09-30 | Amgen Inc. | Benzo[d]imidazol analogs as vanilloid receptor ligands and their use in treatments |
| JO2787B1 (en) | 2005-04-27 | 2014-03-15 | امجين إنك, | Alternative amide derivatives and methods of use |
| WO2007024294A2 (en) | 2005-05-03 | 2007-03-01 | Cgi Pharmaceuticals, Inc. | Certain substituted ureas, as modulators of kinase activity |
| NZ564065A (en) * | 2005-05-20 | 2011-03-31 | Vertex Pharma | Pyrrolopyridines useful as inhibitors of protein kinase |
| KR20080026654A (ko) * | 2005-07-14 | 2008-03-25 | 아스텔라스세이야쿠 가부시키가이샤 | 헤테로시클릭 야누스 키나제 3 억제제 |
| EP1912639A4 (en) * | 2005-08-08 | 2011-10-12 | Janssen Pharmaceutica Nv | Thiazolopyrimidine KINASE INHIBITORS |
| PE20070427A1 (es) | 2005-08-30 | 2007-04-21 | Novartis Ag | Compuestos derivados de benzimidazoles sustituidos como inhibidores de tirosina quinasas |
| US7820821B2 (en) | 2006-02-10 | 2010-10-26 | Transtech Pharma, Inc. | Benzazole derivatives, compositions, and methods of use as aurora kinase inhibitors |
| PL2010528T3 (pl) | 2006-04-19 | 2018-03-30 | Novartis Ag | 6-0-podstawione związki benzoksazolowe i benzotiazolowe i sposoby hamowania sygnalizacji csf-1r |
| WO2007124345A2 (en) * | 2006-04-21 | 2007-11-01 | The Government Of The United States, As Represented By The Secretary Of Health And Human Services | Beta-amyloid pet imaging agents |
| NZ580671A (en) | 2007-04-16 | 2012-03-30 | Hutchison Medipharma Entpr Ltd | Pyrimidine derivatives |
| ES2452349T3 (es) * | 2007-05-21 | 2014-04-01 | Novartis Ag | Inhibidores de CSF-1R, composiciones, y métodos de uso |
| CA2689514C (en) * | 2007-06-05 | 2015-09-29 | Takeda Pharmaceutical Company Limited | Heterobicyclic compounds as kinase inhibitors |
| MX2010004620A (es) * | 2007-10-29 | 2010-07-28 | Amgen Inc | Derivados de benzomorfolina y metodos de uso. |
| US20110092452A1 (en) * | 2008-03-05 | 2011-04-21 | The Regents Of The University Of Michigan | Compositions and methods for diagnosing and treating pancreatic cancer |
| UY32138A (es) | 2008-09-25 | 2010-04-30 | Boehringer Ingelheim Int | Amidas sustituidas del ácido 2-(2,6-dicloro-fenilamino)-6-fluoro-1-metil-1h-bencimidazol-5-carboxílico y sus sales farmacéuticamente aceptables |
| EP3924343A1 (en) | 2008-09-26 | 2021-12-22 | Merck Sharp & Dohme Corp. | Novel cyclic benzimidazole derivatives useful anti-diabetic agents |
| US8410284B2 (en) | 2008-10-22 | 2013-04-02 | Merck Sharp & Dohme Corp | Cyclic benzimidazole derivatives useful as anti-diabetic agents |
| WO2010051176A1 (en) | 2008-10-29 | 2010-05-06 | Merck Sharp & Dohme Corp. | Novel cyclic benzimidazole derivatives useful anti-diabetic agents |
| CA2741672A1 (en) | 2008-10-31 | 2010-05-06 | Merck Sharp & Dohme Corp. | Novel cyclic benzimidazole derivatives useful anti-diabetic agents |
| UY32470A (es) | 2009-03-05 | 2010-10-29 | Boehringer Ingelheim Int | Derivados de 2-{2-cloro-5-[(sustituido) metil]fenilamino} -1-metil]fenilamino}-1-metilbencimidazol-5-carboxamidas-n-(sustituidas) y sus sales fisiológicamente aceptables, composiciones conteniéndolos y aplicaciones |
| EP2408769A1 (en) * | 2009-03-17 | 2012-01-25 | Glaxo Group Limited | Pyrimidine derivatives used as itk inhibitors |
| KR101837759B1 (ko) * | 2010-02-18 | 2018-04-26 | 브이티브이 테라퓨틱스 엘엘씨 | 치환된 융합 이미다졸 유도체, 약학적 조성물, 및 그것의 사용 방법 |
| US8759535B2 (en) | 2010-02-18 | 2014-06-24 | High Point Pharmaceuticals, Llc | Substituted fused imidazole derivatives, pharmaceutical compositions, and methods of use thereof |
| AU2011218830B2 (en) | 2010-02-25 | 2014-07-24 | Merck Sharp & Dohme Corp. | Novel cyclic benzimidazole derivatives useful anti-diabetic agents |
| KR101372721B1 (ko) | 2010-06-18 | 2014-03-14 | 이화여자대학교 산학협력단 | Ｉｎｔｅｒｌｅｕｋｉｎ―６ 억제 작용을 갖는 신규한 벤즈옥사졸 유도체, 이의 제조 방법 및 이를 포함하는 약학적 조성물 |
| US8586604B2 (en) | 2010-08-20 | 2013-11-19 | Boehringer Ingelheim International Gmbh | Inhibitors of the microsomal prostaglandin E2 synthase-1 |
| US8759537B2 (en) | 2010-08-20 | 2014-06-24 | Boehringer Ingelheim International Gmbh | 3H-imidazo [4, 5-C] pyridine-6-carboxamides as anti-inflammatory agents |
| MX344521B (es) | 2010-11-19 | 2016-12-19 | Ligand Pharm Inc | Aminas heterociclicas y sus usos. |
| US8486968B2 (en) | 2010-12-10 | 2013-07-16 | Boehringer Ingelheim International Gmbh | Compounds |
| UY33779A (es) | 2010-12-10 | 2012-07-31 | Boehringer Ingelheim Int | ?2-(fenilamino)-1H-bencimidazol-5-carboxamidas novedosas? |
| US8466186B2 (en) | 2010-12-10 | 2013-06-18 | Boehringer Ingelheim International Gmbh | Compounds |
| CA2851155C (en) | 2011-10-14 | 2021-02-23 | Ambit Biosciences Corporation | Heterocyclic compounds and methods of use thereof |
| GB201201566D0 (en) * | 2012-01-30 | 2012-03-14 | Vernalis R&D Ltd | New chemical compounds |
| WO2014038882A1 (ko) * | 2012-09-07 | 2014-03-13 | 한국생명공학연구원 | 신규 화합물 및 이의 인터루킨-1베타 또는 인터루킨-6 저해 용도 |
| US9242969B2 (en) | 2013-03-14 | 2016-01-26 | Novartis Ag | Biaryl amide compounds as kinase inhibitors |
| US9988386B2 (en) * | 2013-05-30 | 2018-06-05 | Kata Pharmaceuticals, Inc. | Compounds for treatment of diseases of abnormal angiogenesis or aberrant growth factors and uses thereof |
| CN103450093A (zh) * | 2013-09-06 | 2013-12-18 | 中国药科大学 | 2-苄氨基苯并咪唑类化合物及其用途 |
| EP3105210B1 (en) | 2014-02-11 | 2019-01-30 | Bayer Pharma Aktiengesellschaft | Benzimidazol-2-amines as midh1 inhibitors |
| PE20170143A1 (es) | 2014-02-11 | 2017-03-19 | Bayer Pharma AG | Benzimidazol-2-aminas como inhibidores de midh1 |
| CN106879256B (zh) * | 2014-07-31 | 2021-08-03 | 韩国巴斯德研究所 | 2-氨基-苯并咪唑衍生物及其作为5-脂氧合酶和/或前列腺素e合成酶抑制剂的应用 |
| UY36294A (es) | 2014-09-12 | 2016-04-29 | Novartis Ag | Compuestos y composiciones como inhibidores de quinasa |
| US10137110B2 (en) | 2014-10-23 | 2018-11-27 | Bayer Pharma Aktiengesellschaft | 1-cyclohexyl-2-phenylaminobenzimidazoles as mIDH1 inhibitors for the treatment of tumors |
| EP3209646B1 (en) | 2014-10-23 | 2020-07-22 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Benzimidazol-2-amines as midh1 inhibitors |
| WO2016089648A1 (en) | 2014-12-01 | 2016-06-09 | Vtv Therapeutics Llc | Bach 1 inhibitors in combination with nrf2 activators and pharmaceutical compositions thereof |
| CN105949178B (zh) * | 2015-03-09 | 2020-05-26 | 西格莱(苏州)生物医药有限公司 | 一种苯并咪唑类化合物、其制备方法、中间体及应用 |
| US10807983B2 (en) | 2015-03-16 | 2020-10-20 | Ligand Pharmaceuticals, Inc. | Imidazo-fused heterocycles and uses thereof |
| EP3303302B1 (en) | 2015-06-08 | 2019-03-20 | Bayer Pharma Aktiengesellschaft | N-menthylbenzimidazoles as midh1 inhibitors |
| JP6824954B2 (ja) | 2015-07-16 | 2021-02-03 | ドイチェス クレープスフォルシュングスツェントルム シュティフトゥング デス エッフェントリッヒェン レヒツ | ｍＩＤＨ１阻害剤としての５−ヒドロキシアルキルベンズイミダゾール |
| SG10201912699RA (en) | 2015-07-20 | 2020-02-27 | Genzyme Corp | Colony stimulating factor-1 receptor (csf-1r) inhibitors |
| EP3121166A1 (en) * | 2015-07-21 | 2017-01-25 | Bayer Pharma Aktiengesellschaft | Fused imidazoles as midh1 inhibitors |
| CN105085388B (zh) * | 2015-09-06 | 2018-07-13 | 合肥华方医药科技有限公司 | 一种索拉非尼中间体的合成方法 |
| CN105061331A (zh) * | 2015-09-21 | 2015-11-18 | 董瑞兰 | 一种用于小儿祛痰的药物组合物 |
| WO2017049462A1 (zh) * | 2015-09-22 | 2017-03-30 | 合肥中科普瑞昇生物医药科技有限公司 | 一类新型的flt3激酶抑制剂及其用途 |
| EP3390387B1 (en) | 2015-12-18 | 2021-11-17 | Bayer Pharma Aktiengesellschaft | Heteroarylbenzimidazole compounds |
| US20190060286A1 (en) | 2016-02-29 | 2019-02-28 | University Of Florida Research Foundation, Incorpo | Chemotherapeutic Methods |
| WO2017207534A1 (en) | 2016-06-03 | 2017-12-07 | Bayer Pharma Aktiengesellschaft | Substituted heteroarylbenzimidazole compounds |
| CN106008336A (zh) * | 2016-06-29 | 2016-10-12 | 上海工程技术大学 | 4-氯-6,7-二甲氧基喹啉的制备方法 |
| WO2018051306A1 (en) | 2016-09-19 | 2018-03-22 | Novartis Ag | Therapeutic combinations comprising a raf inhibitor and a erk inhibitor |
| WO2018069893A1 (en) * | 2016-10-14 | 2018-04-19 | Novartis Ag | Methods for treating ocular disease using inhibitors of csf-1r |
| KR20240032157A (ko) | 2017-05-02 | 2024-03-08 | 노파르티스 아게 | 병용 요법 |
| US12415816B2 (en) | 2018-11-07 | 2025-09-16 | Dana-Farber Cancer Institute, Inc. | Benzothiazole derivatives and 7-aza-benzothiazole derivatives as janus kinase 2 inhibitors and uses thereof |
| WO2020097400A1 (en) | 2018-11-07 | 2020-05-14 | Dana-Farber Cancer Institute, Inc. | Imidazopyridine derivatives and aza-imidazopyridine derivatives as janus kinase 2 inhibitors and uses thereof |
| US12522583B2 (en) | 2018-11-07 | 2026-01-13 | Dana-Farber Cancer Institute, Inc. | Benzimidazole derivatives and aza-benzimidazole derivatives as Janus kinase 2 inhibitors and uses thereof |
| CN113557019A (zh) * | 2019-01-18 | 2021-10-26 | Vtv治疗有限责任公司 | 取代的稠和咪唑衍生物和治疗镰状细胞病和相关并发症的方法 |
| MX2021013817A (es) | 2019-05-13 | 2021-12-14 | Novartis Ag | Nuevas formas cristalinas de n-(3-(2-(2-hidroxietoxi)-6-morfolinop iridin-4-il)-4-metilfenil)-2-(trifluorometil)isonicotinamida como inhibidores de raf para el tratamiento del cancer. |
| CN112759588B (zh) * | 2019-10-21 | 2023-01-31 | 复旦大学 | 苯并五元杂环胺类衍生物及其用途 |
| TW202204350A (zh) | 2020-05-06 | 2022-02-01 | 美商雅捷可斯治療公司 | 作為ｊａｋ２抑制劑之６－雜芳基氧基苯并咪唑及氮雜苯并咪唑 |
| EP4263531A2 (en) * | 2020-12-16 | 2023-10-25 | IFM Due, Inc. | Compounds and compositions for treating conditions associated with sting activity |
| US12043632B2 (en) * | 2020-12-23 | 2024-07-23 | Ajax Therapeutics, Inc. | 6-heteroaryloxy benzimidazoles and azabenzimidazoles as JAK2 inhibitors |
| WO2023009708A1 (en) * | 2021-07-29 | 2023-02-02 | Ajax Therapeutics, Inc. | Heteroaryloxy triazolo- and imidazo-azines as jak2 inhibitors |
| WO2023086320A1 (en) | 2021-11-09 | 2023-05-19 | Ajax Therapeutics, Inc. | Forms and compositions of inhibitors of jak2 |
| CA3234638A1 (en) | 2021-11-09 | 2023-05-19 | Ajax Therapeutics, Inc. | 6-heteroaryloxy benzimidazoles and azabenzimidazoles as jak2 inhibitors |
| WO2023107705A1 (en) | 2021-12-10 | 2023-06-15 | Incyte Corporation | Bicyclic amines as cdk12 inhibitors |
| CN120187435A (zh) * | 2022-10-27 | 2025-06-20 | 香港科技大学 | 肿瘤的治疗或预防方法 |
| CN120187726A (zh) * | 2022-10-27 | 2025-06-20 | 香港科技大学 | 嘧啶并吡咯类似物 |
| KR102841314B1 (ko) * | 2023-10-24 | 2025-08-01 | 경희대학교 산학협력단 | 신규한 우울증 치료용 벤즈옥사졸 화합물 |
| WO2025086243A1 (zh) * | 2023-10-27 | 2025-05-01 | 深圳湾实验室坪山生物医药研发转化中心 | 白细胞受体酪氨酸激酶抑制剂 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE500217A (enExample) * | 1949-12-23 | |||
| JPS57149341A (en) | 1981-03-13 | 1982-09-14 | Dainippon Ink & Chem Inc | Colorant for polyolefin |
| JPH06759B2 (ja) | 1989-09-22 | 1994-01-05 | ファイザー製薬株式会社 | 新規なベンゾイミダゾール化合物 |
| SK278131B6 (en) * | 1993-06-18 | 1996-02-07 | Eva Sidoova | 3-(2-alkylthio-6-benzothiazolylaminomethyl)-2-benzoxazolinthiones and method of their preparation |
| DE19517448A1 (de) | 1995-05-12 | 1996-11-14 | Thomae Gmbh Dr K | Neue Benzothiazole und Benzoxazole, diese Verbindungen enthaltende Arzneimittel und deren Verwendung sowie Verfahren zu ihrer Herstellung |
| EP1341771A2 (en) | 2000-11-29 | 2003-09-10 | Glaxo Group Limited | Benzimidazole derivatives useful as tie-2 and/or vegfr-2 inhibitors |
| JP2005524668A (ja) * | 2002-03-01 | 2005-08-18 | スミスクライン ビーチャム コーポレーション | ジアミノピリミジン類及びそれらの血管新生阻害薬としての使用 |
| US7071216B2 (en) | 2002-03-29 | 2006-07-04 | Chiron Corporation | Substituted benz-azoles and methods of their use as inhibitors of Raf kinase |
| BRPI0412876A (pt) * | 2003-07-22 | 2006-10-03 | Janssen Pharmaceutica Nv | derivados de quinolinona como inibidores de c-fms quinase |
| WO2005073224A2 (en) * | 2004-01-23 | 2005-08-11 | Amgen Inc | Quinoline quinazoline pyridine and pyrimidine counds and their use in the treatment of inflammation angiogenesis and cancer |
| KR20080030058A (ko) * | 2005-07-27 | 2008-04-03 | 에프. 호프만-라 로슈 아게 | 5-ｈｔ6 조절인자로서 4-아릴옥시 퀴놀린 유도체 |
-
2004
- 2004-03-19 US US10/804,915 patent/US7531553B2/en active Active
- 2004-03-22 AU AU2004223827A patent/AU2004223827B2/en not_active Ceased
- 2004-03-22 EP EP04758050A patent/EP1638954A1/en not_active Withdrawn
- 2004-03-22 CA CA002518909A patent/CA2518909A1/en not_active Abandoned
- 2004-03-22 JP JP2006507472A patent/JP2006520805A/ja not_active Withdrawn
- 2004-03-22 MX MXPA05010086A patent/MXPA05010086A/es unknown
- 2004-03-22 WO PCT/US2004/008809 patent/WO2004085425A1/en not_active Ceased
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2006520805A5 (enExample) | ||
| JP2006502112A5 (enExample) | ||
| CA2807620C (en) | Pharmaceutically active compounds as axl inhibitors | |
| TW202122387A (zh) | Mta協同性之prmt5抑制劑 | |
| JP2021501220A5 (enExample) | ||
| JP2013505930A5 (enExample) | ||
| RU2018123779A (ru) | Новые соединения | |
| JP2007504148A5 (enExample) | ||
| JP2004531473A5 (enExample) | ||
| JP2012532931A5 (enExample) | ||
| JP2020514267A5 (enExample) | ||
| JP2016522246A5 (enExample) | ||
| RU2017105296A (ru) | Новые соединения | |
| RU2012126083A (ru) | Производные аминооксазина | |
| TW200538128A (en) | Therapeutic combinations of atypical antipsychotics with corticotropin releasing factor antagonists | |
| HRP20200854T1 (hr) | Novi biciklički inhibitori bromodomene | |
| JP2008525498A5 (enExample) | ||
| JP2017530960A5 (enExample) | ||
| JP2007503450A5 (enExample) | ||
| RU2008141761A (ru) | ИНГИБИТОРЫ с-МЕТ ПРОТЕИНКИНАЗЫ | |
| JP2011510995A5 (enExample) | ||
| JP2009515814A5 (enExample) | ||
| JP2018501315A5 (enExample) | ||
| JP2012506848A5 (enExample) | ||
| JP2008507539A5 (enExample) |