JP2009515814A5 - - Google Patents
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- Publication number
- JP2009515814A5 JP2009515814A5 JP2008503187A JP2008503187A JP2009515814A5 JP 2009515814 A5 JP2009515814 A5 JP 2009515814A5 JP 2008503187 A JP2008503187 A JP 2008503187A JP 2008503187 A JP2008503187 A JP 2008503187A JP 2009515814 A5 JP2009515814 A5 JP 2009515814A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- alkyl
- amino
- membered
- alkoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- -1 amino, hydroxy Chemical group 0.000 claims 22
- 229940124674 VEGF-R inhibitor Drugs 0.000 claims 8
- 125000000623 heterocyclic group Chemical group 0.000 claims 8
- 125000001424 substituent group Chemical group 0.000 claims 5
- 125000004890 (C1-C6) alkylamino group Chemical group 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- 102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 claims 3
- 108700015053 epidermal growth factor receptor activity proteins Proteins 0.000 claims 3
- 125000001475 halogen functional group Chemical group 0.000 claims 3
- YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 claims 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- 229920006395 saturated elastomer Polymers 0.000 claims 3
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 2
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 2
- 125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- RAHBGWKEPAQNFF-UHFFFAOYSA-N motesanib Chemical compound C=1C=C2C(C)(C)CNC2=CC=1NC(=O)C1=CC=CN=C1NCC1=CC=NC=C1 RAHBGWKEPAQNFF-UHFFFAOYSA-N 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 125000004737 (C1-C6) haloalkoxy group Chemical group 0.000 claims 1
- XDAJGTZDOAYOQF-UHFFFAOYSA-N 2-(pyridin-4-ylmethylamino)-n-[3-(2-pyrrolidin-1-ylethoxy)-4-(trifluoromethyl)phenyl]pyridine-3-carboxamide Chemical compound C1=C(OCCN2CCCC2)C(C(F)(F)F)=CC=C1NC(=O)C1=CC=CN=C1NCC1=CC=NC=C1 XDAJGTZDOAYOQF-UHFFFAOYSA-N 0.000 claims 1
- BJLYRLSMUFCKRS-SFHVURJKSA-N 2-(pyridin-4-ylmethylamino)-n-[3-[[(2s)-pyrrolidin-2-yl]methoxy]-5-(trifluoromethyl)phenyl]pyridine-3-carboxamide Chemical compound C=1C(OC[C@H]2NCCC2)=CC(C(F)(F)F)=CC=1NC(=O)C1=CC=CN=C1NCC1=CC=NC=C1 BJLYRLSMUFCKRS-SFHVURJKSA-N 0.000 claims 1
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 claims 1
- QLLWWEAXSIENQS-HLJPNSHOSA-N 3-[2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-5-(trifluoromethyl)phenyl]-2-(pyridin-4-ylmethylamino)-2H-pyridine-3-carboxamide Chemical compound CN1[C@@H](CCC1)COC1=C(C=C(C=C1)C(F)(F)F)C1(C(N=CC=C1)NCC1=CC=NC=C1)C(=O)N QLLWWEAXSIENQS-HLJPNSHOSA-N 0.000 claims 1
- DHVHQZSWWJWAHU-UHFFFAOYSA-N 6-fluoro-n-(4-propan-2-ylphenyl)-2-(pyridin-4-ylmethylamino)pyridine-3-carboxamide Chemical compound C1=CC(C(C)C)=CC=C1NC(=O)C1=CC=C(F)N=C1NCC1=CC=NC=C1 DHVHQZSWWJWAHU-UHFFFAOYSA-N 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 238000011226 adjuvant chemotherapy Methods 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 claims 1
- 125000002618 bicyclic heterocycle group Chemical group 0.000 claims 1
- 229960005395 cetuximab Drugs 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 125000001188 haloalkyl group Chemical group 0.000 claims 1
- 201000010536 head and neck cancer Diseases 0.000 claims 1
- 208000014829 head and neck neoplasm Diseases 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 125000006517 heterocyclyl carbonyl group Chemical group 0.000 claims 1
- 125000005844 heterocyclyloxy group Chemical group 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 125000004674 methylcarbonyl group Chemical group CC(=O)* 0.000 claims 1
- 125000004170 methylsulfonyl group Chemical group [H]C([H])([H])S(*)(=O)=O 0.000 claims 1
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims 1
- BXOKJVYFRVHMLH-UHFFFAOYSA-N n-(3,3-dimethyl-2h-1-benzofuran-6-yl)-2-(pyridin-4-ylmethylamino)pyridine-3-carboxamide Chemical compound C=1C=C2C(C)(C)COC2=CC=1NC(=O)C1=CC=CN=C1NCC1=CC=NC=C1 BXOKJVYFRVHMLH-UHFFFAOYSA-N 0.000 claims 1
- VKWMLHPKHNARJP-UHFFFAOYSA-N n-(5-tert-butyl-1h-pyrazol-3-yl)-2-(pyridin-4-ylmethylamino)pyridine-3-carboxamide Chemical compound N1N=C(C(C)(C)C)C=C1NC(=O)C1=CC=CN=C1NCC1=CC=NC=C1 VKWMLHPKHNARJP-UHFFFAOYSA-N 0.000 claims 1
- AQWGAPPVYTUUIN-UHFFFAOYSA-N n-[3-(azetidin-3-ylmethoxy)-5-(trifluoromethyl)phenyl]-2-(pyridin-4-ylmethylamino)pyridine-3-carboxamide Chemical compound C=1C(OCC2CNC2)=CC(C(F)(F)F)=CC=1NC(=O)C1=CC=CN=C1NCC1=CC=NC=C1 AQWGAPPVYTUUIN-UHFFFAOYSA-N 0.000 claims 1
- HXCBNDBUQHHIMJ-UHFFFAOYSA-N n-[3-piperidin-4-yloxy-5-(trifluoromethyl)phenyl]-2-(2-pyridin-3-ylethylamino)pyridine-3-carboxamide Chemical compound C=1C(OC2CCNCC2)=CC(C(F)(F)F)=CC=1NC(=O)C1=CC=CN=C1NCCC1=CC=CN=C1 HXCBNDBUQHHIMJ-UHFFFAOYSA-N 0.000 claims 1
- CDDOBCDZFDMVIQ-SFHVURJKSA-N n-[4-(1,1,2,2,2-pentafluoroethyl)-3-[[(2s)-pyrrolidin-2-yl]methoxy]phenyl]-2-(pyridin-4-ylmethylamino)pyridine-3-carboxamide Chemical compound C1=C(OC[C@H]2NCCC2)C(C(F)(F)C(F)(F)F)=CC=C1NC(=O)C1=CC=CN=C1NCC1=CC=NC=C1 CDDOBCDZFDMVIQ-SFHVURJKSA-N 0.000 claims 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 1
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 1
- 125000004043 oxo group Chemical group O=* 0.000 claims 1
- 229960001972 panitumumab Drugs 0.000 claims 1
- 125000004527 pyrimidin-4-yl group Chemical group N1=CN=C(C=C1)* 0.000 claims 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims 1
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 1
- 239000002525 vasculotropin inhibitor Substances 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US66438105P | 2005-03-22 | 2005-03-22 | |
| US60/664,381 | 2005-03-22 | ||
| US11/386,271 US20060216288A1 (en) | 2005-03-22 | 2006-03-21 | Combinations for the treatment of cancer |
| US11/386,271 | 2006-03-21 | ||
| PCT/US2006/010582 WO2006102504A2 (en) | 2005-03-22 | 2006-03-22 | Combinations for the treatment of cancer comprising anti-egfr antibody and vegfr inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009515814A JP2009515814A (ja) | 2009-04-16 |
| JP2009515814A5 true JP2009515814A5 (enExample) | 2009-05-28 |
| JP5142981B2 JP5142981B2 (ja) | 2013-02-13 |
Family
ID=37035437
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008503187A Expired - Fee Related JP5142981B2 (ja) | 2005-03-22 | 2006-03-22 | 抗ｅｇｆｒ抗体およびｖｅｇｆｒ阻害剤を含む、癌の治療のための組み合わせ |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US20060216288A1 (enExample) |
| EP (1) | EP1915151B1 (enExample) |
| JP (1) | JP5142981B2 (enExample) |
| AU (1) | AU2006226897B2 (enExample) |
| CA (1) | CA2600195C (enExample) |
| MX (1) | MX2007011545A (enExample) |
| WO (1) | WO2006102504A2 (enExample) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2539324A1 (en) | 2003-09-18 | 2005-03-31 | Macusight, Inc. | Transscleral delivery |
| US8663639B2 (en) | 2005-02-09 | 2014-03-04 | Santen Pharmaceutical Co., Ltd. | Formulations for treating ocular diseases and conditions |
| BRPI0607606B1 (pt) * | 2005-02-09 | 2021-06-22 | Santen Pharmaceutical, Co., Ltd. | Formulação líquida |
| AU2006227116A1 (en) * | 2005-03-21 | 2006-09-28 | Santen Pharmaceutical Co., Ltd. | Drug delivery systems for treatment of diseases or conditions |
| AR059066A1 (es) * | 2006-01-27 | 2008-03-12 | Amgen Inc | Combinaciones del inhibidor de la angiopoyetina -2 (ang2) y el inhibidor del factor de crecimiento endotelial vascular (vegf) |
| CN101605529B (zh) * | 2006-02-09 | 2013-03-13 | 参天制药株式会社 | 稳定制剂及它们的制备和使用方法 |
| BRPI0709016A2 (pt) | 2006-03-23 | 2011-06-21 | Macusight Inc | formulações e métodos para doenças ou condições relacionadas com a permeabilidade vascular |
| TW200831129A (en) * | 2006-10-06 | 2008-08-01 | Amgen Inc | Stable formulations |
| CA2679859A1 (en) | 2006-11-01 | 2008-05-15 | George Mason Intellectual Properties, Inc. | Method for detecting and controlling cancer |
| AU2008221118B2 (en) | 2007-03-01 | 2013-10-03 | Les Laboratoires Servier | Recombinant anti-epidermal growth factor receptor antibody compositions |
| EP2182941B1 (en) | 2007-07-25 | 2018-02-28 | Eisai R&D Management Co., Ltd. | Multikinase inhibitors for use in the treatment of cancer |
| CN101827523A (zh) * | 2007-08-16 | 2010-09-08 | 马库赛特公司 | 用于治疗眼部疾病或病症的制剂 |
| TWI436775B (zh) * | 2007-08-24 | 2014-05-11 | Oncotherapy Science Inc | 以抗原胜肽合併化療藥劑治療胰臟癌 |
| FR2921657A1 (fr) * | 2007-09-28 | 2009-04-03 | Sanofi Aventis Sa | Derives de nicotinamide, leur preparation et leur application en therapeutique |
| WO2009058908A2 (en) * | 2007-10-29 | 2009-05-07 | Eisai R & D Management Co., Ltd. | Methods for prognosing the ability of a zearalenone analog compound to treat cancer |
| WO2009062199A1 (en) * | 2007-11-09 | 2009-05-14 | Fox Chase Cancer Center | EGFR/NEDD9/TGF-β LNTERACTOME AND METHODS OF USE THEREOF FOR THE IDENTIFICATION OF AGENTS HAVING EFFICACY IN THE TREATMENT OF HYPERPROLIFERATIVE DISORDERS |
| US20130331294A1 (en) | 2007-11-09 | 2013-12-12 | Fox Chase Cancer Center | Egfr/nedd9/tgf-beta interactome and methods of use thereof for the identification of agents having efficacy in the treatment of hyperproliferative disorders |
| AU2009221808A1 (en) * | 2008-03-06 | 2009-09-11 | Genentech, Inc. | Combination therapy with c-met and EGFR antagonists |
| JP2011513432A (ja) * | 2008-03-06 | 2011-04-28 | ジェネンテック， インコーポレイテッド | ｃ−ｍｅｔ及びＨＥＲアンタゴニストの併用療法 |
| US20120035183A1 (en) * | 2008-03-19 | 2012-02-09 | Gilmer Tona M | Cancer Treatment Method |
| JP5719298B2 (ja) | 2008-08-29 | 2015-05-13 | シムフォゲン・アクティーゼルスカブＳｙｍｐｈｏｇｅｎ Ａ／Ｓ | 組換え抗上皮増殖因子受容体抗体組成物 |
| WO2012082337A2 (en) | 2010-12-17 | 2012-06-21 | Glaxo Wellcome Manufacturing Pte Ltd | Combination |
| WO2012099968A1 (en) * | 2011-01-19 | 2012-07-26 | The Trustees Of The University Of Pennsylvania | Compositions and methods for treating skin cancer associated diseases |
| WO2012106302A1 (en) * | 2011-02-01 | 2012-08-09 | Glaxo Wellcome Manufacturing Pte Ltd | Combination |
| AR086823A1 (es) | 2011-06-30 | 2014-01-22 | Genentech Inc | Formulaciones de anticuerpo anti-c-met, metodos |
| JP6441792B2 (ja) | 2012-05-17 | 2018-12-19 | ソレント・セラピューティクス・インコーポレイテッドＳｏｒｒｅｎｔｏ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． | Ｅｇｆｒに結合する抗原結合蛋白質 |
| PT2884979T (pt) | 2012-08-17 | 2019-09-04 | Hoffmann La Roche | Terapêuticas combinadas para o melanoma, compreendendo a administração de cobimetinib e vemurafinib |
| CN107002119A (zh) | 2014-03-24 | 2017-08-01 | 豪夫迈·罗氏有限公司 | 使用c‑met拮抗剂的癌症治疗及前者与hgf表达的关联 |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4943533A (en) * | 1984-03-01 | 1990-07-24 | The Regents Of The University Of California | Hybrid cell lines that produce monoclonal antibodies to epidermal growth factor receptor |
| JP3040121B2 (ja) * | 1988-01-12 | 2000-05-08 | ジェネンテク，インコーポレイテッド | 増殖因子レセプターの機能を阻害することにより腫瘍細胞を処置する方法 |
| US5521184A (en) * | 1992-04-03 | 1996-05-28 | Ciba-Geigy Corporation | Pyrimidine derivatives and processes for the preparation thereof |
| US5700823A (en) * | 1994-01-07 | 1997-12-23 | Sugen, Inc. | Treatment of platelet derived growth factor related disorders such as cancers |
| US20050241006A1 (en) * | 1995-04-27 | 2005-10-27 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| GB9508538D0 (en) * | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quinazoline derivatives |
| US5747498A (en) * | 1996-05-28 | 1998-05-05 | Pfizer Inc. | Alkynyl and azido-substituted 4-anilinoquinazolines |
| CO4950519A1 (es) * | 1997-02-13 | 2000-09-01 | Novartis Ag | Ftalazinas, preparaciones farmaceuticas que las comprenden y proceso para su preparacion |
| US6235883B1 (en) * | 1997-05-05 | 2001-05-22 | Abgenix, Inc. | Human monoclonal antibodies to epidermal growth factor receptor |
| GB9800569D0 (en) * | 1998-01-12 | 1998-03-11 | Glaxo Group Ltd | Heterocyclic compounds |
| UA60365C2 (uk) * | 1998-06-04 | 2003-10-15 | Пфайзер Продактс Інк. | Похідні ізотіазолу, спосіб їх одержання, фармацевтична композиція та спосіб лікування гіперпроліферативного захворювання у ссавця |
| EP1140840B1 (en) * | 1999-01-13 | 2006-03-22 | Bayer Pharmaceuticals Corp. | -g(v)-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors |
| ATE538794T1 (de) * | 1999-01-13 | 2012-01-15 | Bayer Healthcare Llc | Gamma carboxyarylsubstituierte diphenylharnstoffverbindungen als p38 kinasehemmer |
| US7928239B2 (en) * | 1999-01-13 | 2011-04-19 | Bayer Healthcare Llc | Inhibition of RAF kinase using quinolyl, isoquinolyl or pyridyl ureas |
| JP3789066B2 (ja) * | 1999-12-08 | 2006-06-21 | 三菱電機株式会社 | 液晶表示装置 |
| US6515004B1 (en) * | 1999-12-15 | 2003-02-04 | Bristol-Myers Squibb Company | N-[5-[[[5-alkyl-2-oxazolyl]methyl]thio]-2-thiazolyl]-carboxamide inhibitors of cyclin dependent kinases |
| US8725620B2 (en) * | 2000-07-10 | 2014-05-13 | Nobuyoshi Morimoto | System and method for negotiating improved terms for products and services being purchased through the internet |
| GB0017635D0 (en) * | 2000-07-18 | 2000-09-06 | Pharmacia & Upjohn Spa | Antitumor combined therapy |
| US6630500B2 (en) * | 2000-08-25 | 2003-10-07 | Cephalon, Inc. | Selected fused pyrrolocarbazoles |
| US6995162B2 (en) * | 2001-01-12 | 2006-02-07 | Amgen Inc. | Substituted alkylamine derivatives and methods of use |
| US6878714B2 (en) * | 2001-01-12 | 2005-04-12 | Amgen Inc. | Substituted alkylamine derivatives and methods of use |
| EP1578346A4 (en) * | 2001-12-04 | 2007-11-28 | Onyx Pharma Inc | INHIBITORS OF THE RAF-MEK-ERK PATHWAY TO TREAT CANCER |
| CN1625602A (zh) * | 2002-03-13 | 2005-06-08 | 霍夫曼-拉罗奇有限公司 | 选择药物敏感性决定因子的方法和利用所选择的因子预测药物敏感性的方法 |
| WO2003099205A2 (en) * | 2002-05-20 | 2003-12-04 | Abgenix, Inc. | Treatment of renal carcinoma using antibodies against the egfr |
| US20040147428A1 (en) * | 2002-11-15 | 2004-07-29 | Pluenneke John D. | Methods of treatment using an inhibitor of epidermal growth factor receptor |
| EP1663978B1 (en) * | 2003-07-23 | 2007-11-28 | Bayer Pharmaceuticals Corporation | Fluoro substituted omega-carboxyaryl diphenyl urea for the treatment and prevention of diseases and conditions |
| BRPI0509495A2 (pt) * | 2004-02-06 | 2016-10-11 | Nymox Corp | anticorpo humanizado |
-
2006
- 2006-03-21 US US11/386,271 patent/US20060216288A1/en not_active Abandoned
- 2006-03-22 MX MX2007011545A patent/MX2007011545A/es active IP Right Grant
- 2006-03-22 WO PCT/US2006/010582 patent/WO2006102504A2/en not_active Ceased
- 2006-03-22 CA CA2600195A patent/CA2600195C/en not_active Expired - Fee Related
- 2006-03-22 EP EP06739398A patent/EP1915151B1/en active Active
- 2006-03-22 AU AU2006226897A patent/AU2006226897B2/en not_active Ceased
- 2006-03-22 JP JP2008503187A patent/JP5142981B2/ja not_active Expired - Fee Related
-
2009
- 2009-11-19 US US12/592,103 patent/US20100074909A1/en not_active Abandoned
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