JP2020514267A5 - - Google Patents
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- JP2020514267A5 JP2020514267A5 JP2019533465A JP2019533465A JP2020514267A5 JP 2020514267 A5 JP2020514267 A5 JP 2020514267A5 JP 2019533465 A JP2019533465 A JP 2019533465A JP 2019533465 A JP2019533465 A JP 2019533465A JP 2020514267 A5 JP2020514267 A5 JP 2020514267A5
- Authority
- JP
- Japan
- Prior art keywords
- pyrazole
- trifluoromethyl
- carboxamide
- triazole
- chloro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662437384P | 2016-12-21 | 2016-12-21 | |
| US62/437,384 | 2016-12-21 | ||
| PCT/US2017/067516 WO2018119036A1 (en) | 2016-12-21 | 2017-12-20 | Pyrazole derivatives as malt1 inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020514267A JP2020514267A (ja) | 2020-05-21 |
| JP2020514267A5 true JP2020514267A5 (enExample) | 2021-02-04 |
| JP7138641B2 JP7138641B2 (ja) | 2022-09-16 |
Family
ID=61628454
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019533465A Active JP7138641B2 (ja) | 2016-12-21 | 2017-12-20 | Ｍａｌｔ１阻害剤としてのピラゾール誘導体 |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US10954214B2 (enExample) |
| EP (1) | EP3558969B1 (enExample) |
| JP (1) | JP7138641B2 (enExample) |
| KR (1) | KR102583317B1 (enExample) |
| CN (1) | CN110214136A (enExample) |
| AR (1) | AR110421A1 (enExample) |
| AU (2) | AU2017382185C1 (enExample) |
| BR (1) | BR112019012355A2 (enExample) |
| CA (1) | CA3048027A1 (enExample) |
| CL (1) | CL2019001709A1 (enExample) |
| CO (1) | CO2019006622A2 (enExample) |
| EA (1) | EA201991503A1 (enExample) |
| ES (1) | ES2992411T3 (enExample) |
| IL (1) | IL267343B2 (enExample) |
| MA (1) | MA47125A (enExample) |
| MX (2) | MX392673B (enExample) |
| PE (1) | PE20191755A1 (enExample) |
| PH (1) | PH12019501212A1 (enExample) |
| TN (1) | TN2019000192A1 (enExample) |
| TW (1) | TWI795381B (enExample) |
| UA (1) | UA127920C2 (enExample) |
| UY (1) | UY37537A (enExample) |
| WO (1) | WO2018119036A1 (enExample) |
Families Citing this family (72)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20170107216A1 (en) | 2015-10-19 | 2017-04-20 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
| MD3377488T2 (ro) | 2015-11-19 | 2023-02-28 | Incyte Corp | Compuși heterociclici ca imunomodulatori |
| ES2916874T3 (es) | 2015-12-17 | 2022-07-06 | Incyte Corp | Derivados de N-fenil-piridina-2-carboxamida y su uso como moduladores de la interacción proteína/proteína PD-1/PD-L1 |
| CA3009474A1 (en) | 2015-12-22 | 2017-06-29 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
| ES2906460T3 (es) | 2016-05-06 | 2022-04-18 | Incyte Corp | Compuestos heterocíclicos como inmunomoduladores |
| EP3464279B1 (en) | 2016-05-26 | 2021-11-24 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
| SG11201811414TA (en) | 2016-06-20 | 2019-01-30 | Incyte Corp | Heterocyclic compounds as immunomodulators |
| MA45669A (fr) | 2016-07-14 | 2019-05-22 | Incyte Corp | Composés hétérocycliques utilisés comme immunomodulateurs |
| US20180057486A1 (en) | 2016-08-29 | 2018-03-01 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
| TWI795381B (zh) | 2016-12-21 | 2023-03-11 | 比利時商健生藥品公司 | 作為ｍａｌｔ１抑制劑之吡唑衍生物 |
| WO2018119286A1 (en) | 2016-12-22 | 2018-06-28 | Incyte Corporation | Bicyclic heteroaromatic compounds as immunomodulators |
| US10308644B2 (en) | 2016-12-22 | 2019-06-04 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
| WO2018119221A1 (en) | 2016-12-22 | 2018-06-28 | Incyte Corporation | Pyridine derivatives as immunomodulators |
| WO2018119236A1 (en) | 2016-12-22 | 2018-06-28 | Incyte Corporation | Triazolo[1,5-a]pyridine derivatives as immunomodulators |
| RU2764243C2 (ru) | 2017-09-22 | 2022-01-14 | ДЖУБИЛАНТ ЭПИПЭД ЭлЭлСи | Гетероциклические соединения в качестве ингибиторов PAD |
| CN111225915B (zh) | 2017-10-18 | 2023-03-07 | 朱比兰特埃皮帕德有限公司 | 作为pad抑制剂的咪唑并吡啶化合物 |
| US11629135B2 (en) | 2017-11-06 | 2023-04-18 | Jubilant Prodell Llc | Pyrimidine derivatives as inhibitors of PD1/PD-L1 activation |
| RS65576B1 (sr) | 2017-11-24 | 2024-06-28 | Jubilant Episcribe Llc | Heterociklična jedinjenja kao inhibitori prmt5 |
| KR20200105678A (ko) | 2017-12-28 | 2020-09-08 | 더 제너럴 하스피탈 코포레이션 | Cbm 시그날로좀 복합체 표적화는 조절 t 세포의 종양 미세환경에 대한 염증유발을 유도함 |
| CN112105610B (zh) | 2018-03-13 | 2024-01-26 | 朱比连特普罗德尔有限责任公司 | 作为pd1/pd-l1相互作用/活化的抑制剂的双环化合物 |
| SMT202300065T1 (it) | 2018-03-30 | 2023-05-12 | Incyte Corp | Composti eterociclici come immunomodulatori |
| CN112752756B (zh) | 2018-05-11 | 2024-06-25 | 因赛特公司 | 作为PD-L1免疫调节剂的四氢-咪唑并[4,5-c]吡啶衍生物 |
| AU2019289223B2 (en) * | 2018-06-18 | 2023-09-21 | Janssen Pharmaceutica Nv | Pyrazole derivatives as MALT1 inhibitors |
| EA202190055A1 (ru) * | 2018-06-18 | 2021-04-23 | Янссен Фармацевтика Нв | Производные пиразола в качестве ингибиторов malt1 |
| TW202045008A (zh) * | 2019-02-01 | 2020-12-16 | 印度商皮埃企業有限公司 | 4-取代的異噁唑/異噁唑啉(雜)芳基脒化合物、及其製備與用途 |
| EP3927324A1 (en) | 2019-02-22 | 2021-12-29 | Janssen Pharmaceutica NV | Pharmaceutical formulations |
| BR112021016400A2 (pt) * | 2019-02-22 | 2021-10-13 | Janssen Pharmaceutica N.V. | Forma cristalina de mono-hidrato de 1-(1-oxo-1,2-di-hidroisoquinolin-5-il)-5-(trifluorometil.)-n-(2-(trifluorometil)piridin-4-il)-1h-pirazol-4-carboxamida |
| US12404260B2 (en) | 2019-04-11 | 2025-09-02 | Janssen Pharmaceutica Nv | Pyridine rings containing derivatives as MALT1 inhibitors |
| TW202115059A (zh) | 2019-08-09 | 2021-04-16 | 美商英塞特公司 | Ｐｄ—１／ｐｄ—ｌ１抑制劑之鹽 |
| JP7559059B2 (ja) | 2019-09-30 | 2024-10-01 | インサイト・コーポレイション | 免疫調節剤としてのピリド［３，２－ｄ］ピリミジン化合物 |
| WO2021080015A1 (en) * | 2019-10-24 | 2021-04-29 | Ono Pharmaceutical Co., Ltd. | Modulators of trek (twik related k+ channels) channel function |
| ES3055177T3 (en) * | 2019-10-30 | 2026-02-10 | Biogen Ma Inc | Condensed pyridazine or pyrimidine as btk inhibitors |
| EP4058461A1 (en) | 2019-11-11 | 2022-09-21 | Incyte Corporation | Salts and crystalline forms of a pd-1/pd-l1 inhibitor |
| CA3162140A1 (en) | 2019-11-22 | 2021-05-27 | Janssen Pharmaceutica Nv | Methods for assessing efficacy of malt1 inhibitors using an nf-kb translocation assay |
| KR20220119037A (ko) | 2019-11-22 | 2022-08-26 | 얀센 파마슈티카 엔.브이. | MALT1 억제제의 효능 평가를 위한 NF-kB 조절 유전자 발현 분석 |
| WO2021138298A1 (en) * | 2019-12-30 | 2021-07-08 | Rheos Medicines, Inc. | Malt1 modulators and uses thereof |
| US20230235077A1 (en) | 2020-06-24 | 2023-07-27 | The General Hospital Corporation | Materials and methods of treating cancer |
| JP2023539729A (ja) * | 2020-08-21 | 2023-09-19 | ヤンセン ファーマシューティカ エヌ．ベー． | Ｍａｌｔ１阻害剤の非晶質形態及びその製剤 |
| EP4199911A1 (en) * | 2020-08-21 | 2023-06-28 | JANSSEN Pharmaceutica NV | Pharmaceutical formulations comprising a malt1 inhibitor and a mixture of polyethylene glycol with a fatty acid |
| WO2022081967A1 (en) * | 2020-10-16 | 2022-04-21 | Rheos Medicines, Inc. | Malt1 modulators and uses thereof |
| US11780836B2 (en) | 2020-11-06 | 2023-10-10 | Incyte Corporation | Process of preparing a PD-1/PD-L1 inhibitor |
| IL302590A (en) | 2020-11-06 | 2023-07-01 | Incyte Corp | Process for preparing PD-1/PD-L1 inhibitor and salts and crystalline forms thereof |
| US11760756B2 (en) | 2020-11-06 | 2023-09-19 | Incyte Corporation | Crystalline form of a PD-1/PD-L1 inhibitor |
| JP2023549835A (ja) * | 2020-11-12 | 2023-11-29 | モノプテロス セラピューティクス，インコーポレーテッド | がんを治療する材料及び方法 |
| GB202018412D0 (en) * | 2020-11-23 | 2021-01-06 | Exscientia Ltd | Malt-1 modulators ii |
| WO2022167962A1 (en) * | 2021-02-04 | 2022-08-11 | Aurigene Discovery Technologies Limited | Substituted pyrazolyl compounds as malt-1 inhibitors |
| EP4301365A1 (en) * | 2021-03-03 | 2024-01-10 | Janssen Pharmaceutica NV | Combination therapy using a malt1 inhibitor and a btk inhibitor |
| KR20230154227A (ko) | 2021-03-03 | 2023-11-07 | 얀센 파마슈티카 엔브이 | 치료적 유효 용량의 malt1 억제제 jnj-67856633(1-(1-옥소-1,2-다이하이드로아이소퀴놀린-5-일)-5-(트라이플루오로메틸)-n-(2-(트라이플루오로메틸)피리딘-4-일)-1h-피라졸-4-카르복스아미드)을 사용하는 병태의 치료 방법 |
| CN117120427B (zh) * | 2021-06-18 | 2026-07-21 | 上海拓界生物医药科技有限公司 | 一种malt1抑制剂及其制备方法和用途 |
| EP4368618A1 (en) * | 2021-07-05 | 2024-05-15 | Betta Pharmaceuticals Co., Ltd | Six-membered aryl or heteroaryl amides, and composition and use thereof |
| CN117715898A (zh) * | 2021-07-05 | 2024-03-15 | 贝达药业股份有限公司 | 六元芳基或杂芳基酰胺类化合物及其组合物和用途 |
| WO2023016995A1 (en) | 2021-08-09 | 2023-02-16 | Janssen Pharmaceutica Nv | Compositions for use in treating b-cell malignancies |
| CN113912511B (zh) * | 2021-11-29 | 2024-02-13 | 广东广康生化科技股份有限公司 | 一种联苯肼酯中间体的合成方法 |
| JP2025501056A (ja) * | 2021-12-30 | 2025-01-17 | シャンハイ ハンソー バイオメディカル カンパニー リミテッド | 三環系誘導体阻害剤、その製造方法と応用 |
| KR20240144146A (ko) | 2022-02-02 | 2024-10-02 | 오노 야꾸힝 고교 가부시키가이샤 | Malt1 저해약을 유효 성분으로서 포함하는 암 치료제 |
| CN119095837A (zh) * | 2022-02-03 | 2024-12-06 | 希四克斯探索有限公司 | 作为malt1抑制剂的杂环衍生物 |
| TW202425968A (zh) * | 2022-08-26 | 2024-07-01 | 美商熱點醫療公司 | 吡唑基磺醯胺化合物及其在療法中之用途 |
| TW202430031A (zh) | 2022-09-30 | 2024-08-01 | 瑞士商先正達農作物保護股份公司 | 殺微生物之吡唑衍生物 |
| TW202430514A (zh) | 2022-09-30 | 2024-08-01 | 瑞士商先正達農作物保護股份公司 | 殺微生物之吡唑衍生物 |
| JP2025539452A (ja) | 2022-11-30 | 2025-12-05 | シンジェンタ クロップ プロテクション アクチェンゲゼルシャフト | 殺微生物テトラヒドロイソキノリン誘導体 |
| CN118206543A (zh) * | 2022-12-15 | 2024-06-18 | 江苏恒瑞医药股份有限公司 | 一种苯并[c][1,2,5]噁二唑化合物的结晶形式及其制备方法 |
| CN118206538A (zh) * | 2022-12-15 | 2024-06-18 | 江苏恒瑞医药股份有限公司 | 一种苯并[c][1,2,5]噁二唑化合物与酒石酸复合物及其晶型 |
| CN120418243A (zh) * | 2022-12-16 | 2025-08-01 | 江苏恒瑞医药股份有限公司 | 一种Malt1抑制剂的磷酸酯前药 |
| TW202515550A (zh) * | 2023-06-29 | 2025-04-16 | 大陸商上海翰森生物醫藥科技有限公司 | 三并環類抑制劑與抗癌劑在製備抗腫瘤藥物中的聯合應用 |
| TW202515873A (zh) * | 2023-06-29 | 2025-04-16 | 大陸商上海翰森生物醫藥科技有限公司 | 一種三并環類衍生物抑制劑的晶型及其製備方法 |
| WO2025069270A1 (ja) * | 2023-09-27 | 2025-04-03 | 日本新薬株式会社 | アザインドール化合物及び医薬 |
| AU2024357109A1 (en) | 2023-10-06 | 2026-03-12 | Ionctura Sa | Combination of roginolisib with a malt1-gls inhibitor |
| WO2025114167A1 (en) | 2023-11-28 | 2025-06-05 | Syngenta Crop Protection Ag | Microbiocidal pyrazole derivatives |
| WO2025174889A1 (en) * | 2024-02-13 | 2025-08-21 | Board Of Regents, The University Of Texas System | Malt1 and btk dual inhibitors |
| WO2025191053A1 (en) | 2024-03-14 | 2025-09-18 | Syngenta Crop Protection Ag | Microbiocidal pyrazole derivatives |
| WO2025210095A1 (en) | 2024-04-03 | 2025-10-09 | Syngenta Crop Protection Ag | Microbiocidal tetrahydroisoquinoline compounds |
| WO2025210096A1 (en) | 2024-04-03 | 2025-10-09 | Syngenta Crop Protection Ag | Fungicidal compositions |
Family Cites Families (71)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6339099B1 (en) | 1997-06-20 | 2002-01-15 | Dupont Pharmaceuticals Company | Guanidine mimics as factor Xa inhibitors |
| GB9721964D0 (en) * | 1997-10-16 | 1997-12-17 | Pfizer Ltd | Isoquinolines |
| DK173431B1 (da) | 1998-03-20 | 2000-10-23 | Gea Farmaceutisk Fabrik As | Farmaceutisk formulering omfattende en 2-[[(2-pyridinyl)methyl]sulfinyl]benzimidazol med anti-ulcusaktivitet samt fremgangs |
| FR2795726A1 (fr) | 1999-06-30 | 2001-01-05 | Aventis Cropscience Sa | Nouveaux pyrazoles fongicides |
| GB9925127D0 (en) | 1999-10-22 | 1999-12-22 | Pharmacia & Upjohn Spa | Oral formulations for anti-tumor compounds |
| AU2002363250A1 (en) | 2001-11-01 | 2003-05-12 | Icagen, Inc. | Pyrazole-amides and-sulfonamides |
| EP1622571A4 (en) * | 2003-04-30 | 2012-05-02 | Agensys Inc | NUCLEIC ACIDS AND CORRESPONDING PROTEINS NAMED 109P1D4 FOR THE TREATMENT AND DETECTION OF CANCER |
| EP1617840A4 (en) | 2003-05-01 | 2008-08-20 | Bristol Myers Squibb Co | PYRAZOLE AMID COMPOUNDS AS KINASE INHIBITORS |
| EP1847531A4 (en) | 2005-02-09 | 2009-04-22 | Takeda Pharmaceutical | PYRAZOLE DERIVATIVE |
| CN100526430C (zh) | 2005-10-19 | 2009-08-12 | 中国石油化工股份有限公司 | 一种生产清洁汽油的方法 |
| TW200738682A (en) * | 2005-12-08 | 2007-10-16 | Organon Nv | Isoquinoline derivatives |
| KR20090007347A (ko) | 2006-03-22 | 2009-01-16 | 버텍스 파마슈티칼스 인코포레이티드 | 증식성 장애의 치료를 위한 ｃ-ＭＥＴ 단백질 키나제 억제제 |
| US20090253673A1 (en) | 2006-07-12 | 2009-10-08 | Min Ge | Substituted Pyrazoles as Ghrelin Receptor Antagonists |
| CN101583601B (zh) | 2007-01-17 | 2013-06-05 | 香港科技大学 | 作为褪黑素受体mt1和mt2的亚型选择性激动剂的异喹诺酮化合物 |
| US8153798B2 (en) | 2007-03-09 | 2012-04-10 | High Point Pharmaceuticals, Llc | Indole- and benzimidazole amides as hydroxysteroid dehydrogenase inhibitors |
| CN101366715A (zh) | 2007-08-15 | 2009-02-18 | 上海医药工业研究院 | 一种雷帕霉素组合物及其制备方法 |
| EP2222326B2 (en) | 2007-11-21 | 2015-02-25 | Vib Vzw | Inhibitors of malt1 proteolytic activity and uses thereof |
| TWI607996B (zh) | 2008-09-24 | 2017-12-11 | 巴地斯顏料化工廠 | 控制無脊椎害蟲之吡唑化合物 |
| WO2010039039A1 (en) | 2008-10-03 | 2010-04-08 | Clavis Pharma Asa | Oral formulations of gemcitabine derivatives |
| KR101061599B1 (ko) | 2008-12-05 | 2011-09-02 | 한국과학기술연구원 | 비정상 세포 성장 질환의 치료를 위한 단백질 키나아제 저해제인 신규 인다졸 유도체, 이의 약학적으로 허용가능한염 및 이를 유효성분으로 함유하는 약학적 조성물 |
| DE102009003954A1 (de) | 2009-01-07 | 2010-07-08 | Merck Patent Gmbh | Pyridazinonderivate |
| US8252821B2 (en) | 2009-04-14 | 2012-08-28 | Bristol-Myers Squibb Company | Bioavailable capsule compositions of amorphous alpha-(N-sulfonamido)acetamide compound |
| WO2011036885A1 (ja) | 2009-09-25 | 2011-03-31 | 武田薬品工業株式会社 | 複素環化合物 |
| MX380504B (es) | 2010-06-03 | 2025-03-12 | Pharmacyclics Llc | El uso de inhibidores de la tirosina quinasa de bruton (btk). |
| US20120071497A1 (en) | 2010-06-03 | 2012-03-22 | Pharmacyclics, Inc. | Methods of treating abc-dlbcl using inhibitors of bruton's tyrosine kinase |
| WO2011161612A1 (en) | 2010-06-22 | 2011-12-29 | Basf Se | Process for preparing 4-hydroxypyridines |
| WO2012004217A1 (en) | 2010-07-06 | 2012-01-12 | Novartis Ag | Cyclic ether compounds useful as kinase inhibitors |
| TW201236685A (en) | 2010-11-11 | 2012-09-16 | Daiichi Sankyo Co Ltd | New pyrazole amide derivatives |
| JP6231085B2 (ja) | 2012-05-31 | 2017-11-15 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | アミノキナゾリン誘導体及びピリドピリミジン誘導体 |
| WO2014033447A2 (en) | 2012-08-29 | 2014-03-06 | Respivert Limited | Kinase inhibitors |
| EA201590916A1 (ru) | 2012-11-09 | 2016-02-29 | Корнэлл Юниверсити | Низкомолекулярные ингибиторы malt1 |
| WO2014086478A1 (en) | 2012-12-03 | 2014-06-12 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) | Inhibitors of malt1 protease |
| MX2015008919A (es) | 2013-01-10 | 2015-10-22 | Gruenenthal Gmbh | Carboxamidas basadas en pirazolilo i como inhibidores del canal de calcio activado por liberacion de calcio (crac). |
| JP2015096499A (ja) | 2013-10-11 | 2015-05-21 | 田辺三菱製薬株式会社 | 医薬組成物 |
| JP6545197B2 (ja) * | 2014-05-28 | 2019-07-17 | ノバルティス アーゲー | 新規なピラゾロピリミジン誘導体およびｍａｌｔ１阻害剤としてのその使用 |
| WO2015192081A1 (en) | 2014-06-13 | 2015-12-17 | Byrd, John C. | Biomarker for predicting response of cll to treatment with a btk inhibitor |
| WO2016005994A2 (en) | 2014-07-06 | 2016-01-14 | Gattefosse India Pvt. Ltd. | Pharmaceutical composition comprising solid dispersion of bcs class ii drugs with gelucires |
| MX2017001656A (es) | 2014-08-08 | 2017-07-24 | Pharmacyclics Llc | Combinaciones de inhibidor de tirosina cinasa de bruton y usos de estas. |
| BR112017004897A2 (pt) | 2014-09-10 | 2017-12-12 | Glaxosmithkline Ip Dev Ltd | compostos inovadores como inibidores rearranjados durante a transfecção (ret) |
| WO2016090382A1 (en) | 2014-12-06 | 2016-06-09 | Intra-Cellular Therapies, Inc. | Organic compounds |
| US10835524B2 (en) | 2015-06-24 | 2020-11-17 | University Of Florida Research Foundation, Incorporated | Compositions for the treatment of pancreatic cancer and uses thereof |
| RS63359B1 (sr) | 2015-11-06 | 2022-07-29 | Incyte Corp | Heterociklična jedinjenja kao inhibitori pi3k-gama |
| EP3374361A1 (en) * | 2015-11-13 | 2018-09-19 | Novartis AG | Novel pyrazolo pyrimidine derivatives |
| JO3794B1 (ar) | 2015-12-10 | 2021-01-31 | Janssen Pharmaceutica Nv | المركبات متعددة الحلقات كمثبطات لتيروزين كيناز بروتون |
| CN107021963A (zh) | 2016-01-29 | 2017-08-08 | 北京诺诚健华医药科技有限公司 | 吡唑稠环类衍生物、其制备方法及其在治疗癌症、炎症和免疫性疾病上的应用 |
| WO2017151786A1 (en) | 2016-03-01 | 2017-09-08 | University Of Maryland, Baltimore | Wnt signaling pathway inhibitors for treatments of disease |
| WO2018020474A1 (en) | 2016-07-29 | 2018-02-01 | Lupin Limited | Substituted thiazolo-pyridine compounds as malt1 inhibitors |
| WO2018103060A1 (en) | 2016-12-09 | 2018-06-14 | Janssen Pharmaceutica Nv | Inhibitors of bruton's tyrosine kinase and methods of their use |
| ES2856248T3 (es) | 2016-12-21 | 2021-09-27 | Acerta Pharma Bv | Inhibidores de imidazopirazina de la tirosina quinasa de Bruton |
| JOP20190141A1 (ar) | 2016-12-21 | 2019-06-12 | Bayer Pharma AG | أشكال جرعات صيدلية تحتوي على مثبطات لقناة task-1 و task-3 واستخدامها في معالجة اضطراب تنفسي |
| TWI795381B (zh) | 2016-12-21 | 2023-03-11 | 比利時商健生藥品公司 | 作為ｍａｌｔ１抑制劑之吡唑衍生物 |
| AU2017381433B2 (en) | 2016-12-21 | 2024-11-14 | Mereo Biopharma 3 Limited | Use of anti-sclerostin antibodies in the treatment of osteogenesis imperfecta |
| JOP20190152A1 (ar) | 2016-12-21 | 2019-06-20 | Novartis Ag | مضادات الميوستاتين، الآكتيفين أو مستقبلات الآكتيفين للاستخدام في علاج السمنة والحالات ذات الصلة |
| JOP20190148A1 (ar) | 2016-12-21 | 2019-06-18 | Bayer Pharma AG | أشكال جرعات صيدلية تحتوي على مثبطات قنوات task-1 و task-3 واستخدامها لمعالجة الاضطرابات التنفسية |
| EP3576744A1 (en) | 2017-02-01 | 2019-12-11 | Medivir Aktiebolag | Therapeutic applications of malt1 inhibitors |
| EP3592731A4 (en) | 2017-03-08 | 2020-10-07 | Cornell University | MALT1 INHIBITORS AND THEIR USES |
| WO2018226150A1 (en) | 2017-06-05 | 2018-12-13 | Medivir Aktiebolag | Pyrazolopyrimidine as malt-1 inhibitors |
| KR20200105678A (ko) | 2017-12-28 | 2020-09-08 | 더 제너럴 하스피탈 코포레이션 | Cbm 시그날로좀 복합체 표적화는 조절 t 세포의 종양 미세환경에 대한 염증유발을 유도함 |
| EP3756268A1 (de) | 2018-02-23 | 2020-12-30 | Industrieanlagen-Betriebsgesellschaft mbH | Vorrichtung zum erzeugen eines magnetfelds, insbesondere für ein induktives ladesystem, und primäreinrichtung eines induktiven ladesystems zum dynamischen aufladen von fahrzeugen |
| EA202190055A1 (ru) | 2018-06-18 | 2021-04-23 | Янссен Фармацевтика Нв | Производные пиразола в качестве ингибиторов malt1 |
| AU2019289223B2 (en) | 2018-06-18 | 2023-09-21 | Janssen Pharmaceutica Nv | Pyrazole derivatives as MALT1 inhibitors |
| BR112021016400A2 (pt) | 2019-02-22 | 2021-10-13 | Janssen Pharmaceutica N.V. | Forma cristalina de mono-hidrato de 1-(1-oxo-1,2-di-hidroisoquinolin-5-il)-5-(trifluorometil.)-n-(2-(trifluorometil)piridin-4-il)-1h-pirazol-4-carboxamida |
| EP3927324A1 (en) | 2019-02-22 | 2021-12-29 | Janssen Pharmaceutica NV | Pharmaceutical formulations |
| US12404260B2 (en) | 2019-04-11 | 2025-09-02 | Janssen Pharmaceutica Nv | Pyridine rings containing derivatives as MALT1 inhibitors |
| CA3162140A1 (en) | 2019-11-22 | 2021-05-27 | Janssen Pharmaceutica Nv | Methods for assessing efficacy of malt1 inhibitors using an nf-kb translocation assay |
| KR20220119037A (ko) | 2019-11-22 | 2022-08-26 | 얀센 파마슈티카 엔.브이. | MALT1 억제제의 효능 평가를 위한 NF-kB 조절 유전자 발현 분석 |
| WO2021138298A1 (en) | 2019-12-30 | 2021-07-08 | Rheos Medicines, Inc. | Malt1 modulators and uses thereof |
| JP2023539729A (ja) | 2020-08-21 | 2023-09-19 | ヤンセン ファーマシューティカ エヌ．ベー． | Ｍａｌｔ１阻害剤の非晶質形態及びその製剤 |
| EP4199911A1 (en) | 2020-08-21 | 2023-06-28 | JANSSEN Pharmaceutica NV | Pharmaceutical formulations comprising a malt1 inhibitor and a mixture of polyethylene glycol with a fatty acid |
| KR20230154227A (ko) | 2021-03-03 | 2023-11-07 | 얀센 파마슈티카 엔브이 | 치료적 유효 용량의 malt1 억제제 jnj-67856633(1-(1-옥소-1,2-다이하이드로아이소퀴놀린-5-일)-5-(트라이플루오로메틸)-n-(2-(트라이플루오로메틸)피리딘-4-일)-1h-피라졸-4-카르복스아미드)을 사용하는 병태의 치료 방법 |
| EP4301365A1 (en) | 2021-03-03 | 2024-01-10 | Janssen Pharmaceutica NV | Combination therapy using a malt1 inhibitor and a btk inhibitor |
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2017
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- 2017-12-20 WO PCT/US2017/067516 patent/WO2018119036A1/en not_active Ceased
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- 2017-12-20 KR KR1020197021137A patent/KR102583317B1/ko active Active
- 2017-12-20 TN TNP/2019/000192A patent/TN2019000192A1/en unknown
- 2017-12-20 EA EA201991503A patent/EA201991503A1/ru unknown
- 2017-12-20 JP JP2019533465A patent/JP7138641B2/ja active Active
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- 2017-12-20 AU AU2017382185A patent/AU2017382185C1/en not_active Ceased
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- 2017-12-20 CN CN201780079706.3A patent/CN110214136A/zh active Pending
- 2017-12-20 BR BR112019012355A patent/BR112019012355A2/pt not_active Application Discontinuation
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2019
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