JP2020514267A5 - - Google Patents
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- Publication number
- JP2020514267A5 JP2020514267A5 JP2019533465A JP2019533465A JP2020514267A5 JP 2020514267 A5 JP2020514267 A5 JP 2020514267A5 JP 2019533465 A JP2019533465 A JP 2019533465A JP 2019533465 A JP2019533465 A JP 2019533465A JP 2020514267 A5 JP2020514267 A5 JP 2020514267A5
- Authority
- JP
- Japan
- Prior art keywords
- pyrazole
- trifluoromethyl
- carboxamide
- triazole
- chloro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662437384P | 2016-12-21 | 2016-12-21 | |
| US62/437,384 | 2016-12-21 | ||
| PCT/US2017/067516 WO2018119036A1 (en) | 2016-12-21 | 2017-12-20 | Pyrazole derivatives as malt1 inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020514267A JP2020514267A (ja) | 2020-05-21 |
| JP2020514267A5 true JP2020514267A5 (enExample) | 2021-02-04 |
| JP7138641B2 JP7138641B2 (ja) | 2022-09-16 |
Family
ID=61628454
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019533465A Active JP7138641B2 (ja) | 2016-12-21 | 2017-12-20 | Ｍａｌｔ１阻害剤としてのピラゾール誘導体 |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US10954214B2 (enExample) |
| EP (1) | EP3558969B1 (enExample) |
| JP (1) | JP7138641B2 (enExample) |
| KR (1) | KR102583317B1 (enExample) |
| CN (1) | CN110214136A (enExample) |
| AR (1) | AR110421A1 (enExample) |
| AU (2) | AU2017382185C1 (enExample) |
| BR (1) | BR112019012355A2 (enExample) |
| CA (1) | CA3048027A1 (enExample) |
| CL (1) | CL2019001709A1 (enExample) |
| CO (1) | CO2019006622A2 (enExample) |
| EA (1) | EA201991503A1 (enExample) |
| ES (1) | ES2992411T3 (enExample) |
| IL (1) | IL267343B2 (enExample) |
| MA (1) | MA47125A (enExample) |
| MX (2) | MX392673B (enExample) |
| PE (1) | PE20191755A1 (enExample) |
| PH (1) | PH12019501212A1 (enExample) |
| TN (1) | TN2019000192A1 (enExample) |
| TW (1) | TWI795381B (enExample) |
| UA (1) | UA127920C2 (enExample) |
| UY (1) | UY37537A (enExample) |
| WO (1) | WO2018119036A1 (enExample) |
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| JP6911031B2 (ja) | 2015-12-22 | 2021-07-28 | インサイト・コーポレイションＩｎｃｙｔｅ Ｃｏｒｐｏｒａｔｉｏｎ | 免疫調節剤としての複素環化合物 |
| TW201808950A (zh) | 2016-05-06 | 2018-03-16 | 英塞特公司 | 作為免疫調節劑之雜環化合物 |
| US20170342060A1 (en) | 2016-05-26 | 2017-11-30 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
| MY197280A (en) | 2016-06-20 | 2023-06-09 | Incyte Corp | Heterocyclic compounds as immunomodulators |
| EP3484866B1 (en) | 2016-07-14 | 2022-09-07 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
| MA46045A (fr) | 2016-08-29 | 2021-04-28 | Incyte Corp | Composés hétérocycliques utilisés comme immunomodulateurs |
| TWI795381B (zh) | 2016-12-21 | 2023-03-11 | 比利時商健生藥品公司 | 作為ｍａｌｔ１抑制劑之吡唑衍生物 |
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| MA47099A (fr) | 2016-12-22 | 2021-05-12 | Incyte Corp | Composés hétéroaromatiques bicycliques utilisés en tant qu'immunomodulateurs |
| BR112019012993A2 (pt) | 2016-12-22 | 2019-12-03 | Incyte Corporation | derivados de benzo-oxazol como imunomoduladores |
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| JP7050335B2 (ja) | 2016-12-21 | 2022-04-08 | メレオ バイオファーマ ３ リミテッド | 骨形成不全症の処置における抗スクレロスチン抗体の使用 |
| JOP20190152A1 (ar) | 2016-12-21 | 2019-06-20 | Novartis Ag | مضادات الميوستاتين، الآكتيفين أو مستقبلات الآكتيفين للاستخدام في علاج السمنة والحالات ذات الصلة |
| JOP20190148A1 (ar) | 2016-12-21 | 2019-06-18 | Bayer Pharma AG | أشكال جرعات صيدلية تحتوي على مثبطات قنوات task-1 و task-3 واستخدامها لمعالجة الاضطرابات التنفسية |
| WO2018141749A1 (en) | 2017-02-01 | 2018-08-09 | Medivir Ab | Therapeutic applications of malt1 inhibitors |
| JP7142022B2 (ja) | 2017-03-08 | 2022-09-26 | コーネル・ユニバーシティー | Ｍａｌｔ１の阻害剤およびそれらの使用 |
| WO2018226150A1 (en) | 2017-06-05 | 2018-12-13 | Medivir Aktiebolag | Pyrazolopyrimidine as malt-1 inhibitors |
| BR112020013285A2 (pt) | 2017-12-28 | 2020-12-01 | The General Hospital Corporation | direcionamento do complexo de sinalossoma cbm que induz células t reguladoras a atingirem o microambiente tumoral |
| WO2019161921A1 (de) | 2018-02-23 | 2019-08-29 | Industrieanlagen-Betriebsgesellschaft Mbh | Vorrichtung zum erzeugen eines magnetfelds, insbesondere für ein induktives ladesystem, und primäreinrichtung eines induktiven ladesystems zum dynamischen aufladen von fahrzeugen |
| JP7296407B2 (ja) | 2018-06-18 | 2023-06-22 | ヤンセン ファーマシューティカ エヌ．ベー． | Ｍａｌｔ１阻害剤としてのピラゾール誘導体 |
| JP7296408B2 (ja) | 2018-06-18 | 2023-06-22 | ヤンセン ファーマシューティカ エヌ．ベー． | Ｍａｌｔ１阻害剤としてのピラゾール誘導体 |
| AU2020225342A1 (en) | 2019-02-22 | 2021-08-19 | Janssen Pharmaceutica Nv | Pharmaceutical formulations |
| AU2020226723B2 (en) | 2019-02-22 | 2025-01-23 | Janssen Pharmaceutica Nv | Crystalline form of 1-(1-oxo-1,2-dihydroisoquinolin-5-yl)-5-(trifluoromethyl)- |
| MA55593A (fr) | 2019-04-11 | 2022-02-16 | Janssen Pharmaceutica Nv | Cycles pyridine contenant des dérivés servant d'inhibiteurs de malt1 |
| CA3162140A1 (en) | 2019-11-22 | 2021-05-27 | Janssen Pharmaceutica Nv | Methods for assessing efficacy of malt1 inhibitors using an nf-kb translocation assay |
| IL293143A (en) | 2019-11-22 | 2022-07-01 | Janssen Pharmaceutica Nv | Nf-kb regulated gene expression assay for assessing efficacy of malt1 inhibitors |
| WO2021138298A1 (en) | 2019-12-30 | 2021-07-08 | Rheos Medicines, Inc. | Malt1 modulators and uses thereof |
| US20230310413A1 (en) | 2020-08-21 | 2023-10-05 | Janssen Pharmaceutica Nv | Pharmaceutical formulations comprising a malt1 inhibitor and a mixture of polyethylene glycol with a fatty acid |
| KR20230054394A (ko) | 2020-08-21 | 2023-04-24 | 얀센 파마슈티카 엔.브이. | 비정질 형태의 malt1 억제제 및 이의 제형 |
| CN117279639A (zh) | 2021-03-03 | 2023-12-22 | 詹森药业有限公司 | 使用治疗有效剂量的malt1抑制剂jnj-67856633（1-(1-氧代-1,2-二氢异喹啉-5-基)-5-(三氟甲基)-n-(2-(三氟甲基)吡啶-4-基)-1h-吡唑-4-甲酰胺）治疗病状的方法 |
| US20220288058A1 (en) | 2021-03-03 | 2022-09-15 | Janssen Pharmaceutica Nv | Combination therapy using a malt1 inhibitor and a btk inhibitor |
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2017
- 2017-12-19 TW TW106144535A patent/TWI795381B/zh active
- 2017-12-20 ES ES17851862T patent/ES2992411T3/es active Active
- 2017-12-20 BR BR112019012355A patent/BR112019012355A2/pt not_active Application Discontinuation
- 2017-12-20 EP EP17851862.7A patent/EP3558969B1/en active Active
- 2017-12-20 AU AU2017382185A patent/AU2017382185C1/en active Active
- 2017-12-20 EA EA201991503A patent/EA201991503A1/ru unknown
- 2017-12-20 KR KR1020197021137A patent/KR102583317B1/ko active Active
- 2017-12-20 JP JP2019533465A patent/JP7138641B2/ja active Active
- 2017-12-20 US US15/847,999 patent/US10954214B2/en active Active
- 2017-12-20 MA MA047125A patent/MA47125A/fr unknown
- 2017-12-20 CN CN201780079706.3A patent/CN110214136A/zh active Pending
- 2017-12-20 WO PCT/US2017/067516 patent/WO2018119036A1/en not_active Ceased
- 2017-12-20 MX MX2019007540A patent/MX392673B/es unknown
- 2017-12-20 UA UAA201908268A patent/UA127920C2/uk unknown
- 2017-12-20 CA CA3048027A patent/CA3048027A1/en active Pending
- 2017-12-20 PE PE2019001288A patent/PE20191755A1/es unknown
- 2017-12-20 TN TNP/2019/000192A patent/TN2019000192A1/en unknown
- 2017-12-21 UY UY0001037537A patent/UY37537A/es not_active Application Discontinuation
- 2017-12-21 AR ARP170103626A patent/AR110421A1/es not_active Application Discontinuation
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2019
- 2019-05-31 PH PH12019501212A patent/PH12019501212A1/en unknown
- 2019-06-13 IL IL267343A patent/IL267343B2/en unknown
- 2019-06-19 CL CL2019001709A patent/CL2019001709A1/es unknown
- 2019-06-21 MX MX2022005827A patent/MX2022005827A/es unknown
- 2019-06-21 CO CONC2019/0006622A patent/CO2019006622A2/es unknown
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2020
- 2020-11-25 US US17/104,081 patent/US12077521B2/en active Active
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2022
- 2022-02-28 AU AU2022201352A patent/AU2022201352A1/en not_active Abandoned
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