JP2007501189A5

JP2007501189A5 -

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Publication number: JP2007501189A5
Authority: JP; Japan
Prior art keywords: substituted; cyclohexyl; quinolin; carboxylic acid; benzimidazole
Prior art date: 2004-07-30
Legal status : Withdrawn

Application number

JP2006522111A

Other languages

English (en)

Japanese (ja)

Other versions

JP2007501189A (ja

Filing date

2004-07-30

Publication date

2007-08-16

2004-07-30 Application filed filed Critical

2004-07-30 Priority claimed from PCT/US2004/024755 external-priority patent/WO2005012288A1/en

2007-01-25 Publication of JP2007501189A publication Critical patent/JP2007501189A/ja

2007-08-16 Publication of JP2007501189A5 publication Critical patent/JP2007501189A5/ja

Status Withdrawn legal-status Critical Current

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-1 guanidino, substituted guanidino, oxycarbonylamino, aminocarbonyloxy, amino carbonylamino, oxycarbonyloxy Chemical group 0.000 claims 272
125000000623 heterocyclic group Chemical group 0.000 claims 171
125000001072 heteroaryl group Chemical group 0.000 claims 146
150000001875 compounds Chemical class 0.000 claims 114
125000003118 aryl group Chemical group 0.000 claims 82
125000003107 substituted aryl group Chemical group 0.000 claims 68
125000000217 alkyl group Chemical group 0.000 claims 50
125000000304 alkynyl group Chemical group 0.000 claims 46
229910052739 hydrogen Inorganic materials 0.000 claims 41
239000001257 hydrogen Substances 0.000 claims 41
125000000547 substituted alkyl group Chemical group 0.000 claims 37
125000000753 cycloalkyl group Chemical group 0.000 claims 35
125000000008 (C1-C10) alkyl group Chemical group 0.000 claims 34
125000003342 alkenyl group Chemical group 0.000 claims 32
150000001412 amines Chemical class 0.000 claims 26
150000002431 hydrogen Chemical class 0.000 claims 26
125000004433 nitrogen atom Chemical group N* 0.000 claims 20
229910052757 nitrogen Inorganic materials 0.000 claims 16
125000005017 substituted alkenyl group Chemical group 0.000 claims 16
125000004426 substituted alkynyl group Chemical group 0.000 claims 16
125000006376 (C3-C10) cycloalkyl group Chemical group 0.000 claims 15
125000006374 C2-C10 alkenyl group Chemical group 0.000 claims 14
125000004170 methylsulfonyl group Chemical group [H]C([H])([H])S(*)(=O)=O 0.000 claims 14
150000003839 salts Chemical class 0.000 claims 14
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 13
125000005843 halogen group Chemical group 0.000 claims 13
125000003170 phenylsulfonyl group Chemical group C1(=CC=CC=C1)S(=O)(=O)* 0.000 claims 12
125000002619 bicyclic group Chemical group 0.000 claims 11
125000005346 substituted cycloalkyl group Chemical group 0.000 claims 11
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 10
125000001424 substituent group Chemical group 0.000 claims 10
125000004093 cyano group Chemical group *C#N 0.000 claims 8
239000000203 mixture Substances 0.000 claims 8
125000001624 naphthyl group Chemical group 0.000 claims 7
125000002252 acyl group Chemical group 0.000 claims 6
125000004423 acyloxy group Chemical group 0.000 claims 6
125000004104 aryloxy group Chemical group 0.000 claims 6
229910052799 carbon Inorganic materials 0.000 claims 6
125000000392 cycloalkenyl group Chemical group 0.000 claims 6
125000004356 hydroxy functional group Chemical group O* 0.000 claims 6
125000003545 alkoxy group Chemical group 0.000 claims 5
125000004432 carbon atom Chemical group C* 0.000 claims 5
125000005415 substituted alkoxy group Chemical group 0.000 claims 5
YXVFYQXJAXKLAK-UHFFFAOYSA-N biphenyl-4-ol Chemical group C1=CC(O)=CC=C1C1=CC=CC=C1 YXVFYQXJAXKLAK-UHFFFAOYSA-N 0.000 claims 4
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 4
125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 4
125000005842 heteroatom Chemical group 0.000 claims 4
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 4
IWUCXVSUMQZMFG-RGDLXGNYSA-N 1-[(2s,3s,4r,5s)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,4-triazole-3-carboxamide Chemical compound N1=C(C(=O)N)N=CN1[C@@H]1[C@@H](O)[C@@H](O)[C@H](CO)O1 IWUCXVSUMQZMFG-RGDLXGNYSA-N 0.000 claims 3
GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical class C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 claims 3
NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims 3
RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims 3
IWUCXVSUMQZMFG-AFCXAGJDSA-N Ribavirin Chemical group N1=C(C(=O)N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 IWUCXVSUMQZMFG-AFCXAGJDSA-N 0.000 claims 3
208000036142 Viral infection Diseases 0.000 claims 3
125000003277 amino group Chemical group 0.000 claims 3
125000004429 atom Chemical group 0.000 claims 3
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
125000004550 quinolin-6-yl group Chemical group N1=CC=CC2=CC(=CC=C12)* 0.000 claims 3
229960000329 ribavirin Drugs 0.000 claims 3
HZCAHMRRMINHDJ-DBRKOABJSA-N ribavirin Natural products O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1N=CN=C1 HZCAHMRRMINHDJ-DBRKOABJSA-N 0.000 claims 3
125000005505 thiomorpholino group Chemical group 0.000 claims 3
230000009385 viral infection Effects 0.000 claims 3
JIDVYZHWJXTAAM-UHFFFAOYSA-N 1-cyclohexyl-2-[2-(4-phenylphenyl)quinolin-6-yl]benzimidazole-5-carboxylic acid Chemical compound C=1C=C2N=C(C=3C=CC(=CC=3)C=3C=CC=CC=3)C=CC2=CC=1C1=NC2=CC(C(=O)O)=CC=C2N1C1CCCCC1 JIDVYZHWJXTAAM-UHFFFAOYSA-N 0.000 claims 2
BYYITRQPHVQEDK-UHFFFAOYSA-N 1-cyclohexyl-2-[2-[2-(4-fluorophenyl)-5-methoxyphenyl]quinolin-6-yl]benzimidazole-5-carboxylic acid Chemical compound C=1C=C2C=C(C=3N(C4=CC=C(C=C4N=3)C(O)=O)C3CCCCC3)C=CC2=NC=1C1=CC(OC)=CC=C1C1=CC=C(F)C=C1 BYYITRQPHVQEDK-UHFFFAOYSA-N 0.000 claims 2
RHDYQUZYHZWTCI-UHFFFAOYSA-N 1-methoxy-4-phenylbenzene Chemical group C1=CC(OC)=CC=C1C1=CC=CC=C1 RHDYQUZYHZWTCI-UHFFFAOYSA-N 0.000 claims 2
FPZWZCWUIYYYBU-UHFFFAOYSA-N 2-(2-ethoxyethoxy)ethyl acetate Chemical group CCOCCOCCOC(C)=O FPZWZCWUIYYYBU-UHFFFAOYSA-N 0.000 claims 2
NLMBEVDGYJPEGP-UHFFFAOYSA-N 2-[2-[2-(4-chlorophenyl)-5-methoxyphenyl]quinolin-6-yl]-1-(4-methylcyclohexyl)benzimidazole-5-carboxylic acid Chemical compound C=1C=C2C=C(C=3N(C4=CC=C(C=C4N=3)C(O)=O)C3CCC(C)CC3)C=CC2=NC=1C1=CC(OC)=CC=C1C1=CC=C(Cl)C=C1 NLMBEVDGYJPEGP-UHFFFAOYSA-N 0.000 claims 2
GRIPBQASSDYJAA-UHFFFAOYSA-N 2-[[1-cyclohexyl-2-(2-phenylquinolin-6-yl)benzimidazole-5-carbonyl]amino]-3-(5-hydroxy-1h-indol-3-yl)propanoic acid Chemical compound C=1NC2=CC=C(O)C=C2C=1CC(C(=O)O)NC(=O)C(C=C1N=C2C=3C=C4C=CC(=NC4=CC=3)C=3C=CC=CC=3)=CC=C1N2C1CCCCC1 GRIPBQASSDYJAA-UHFFFAOYSA-N 0.000 claims 2
125000006276 2-bromophenyl group Chemical group [H]C1=C([H])C(Br)=C(*)C([H])=C1[H] 0.000 claims 2
125000004800 4-bromophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Br 0.000 claims 2
125000000590 4-methylphenyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)C([H])([H])[H] 0.000 claims 2
239000005973 Carvone Substances 0.000 claims 2
241000711549 Hepacivirus C Species 0.000 claims 2
102000006992 Interferon-alpha Human genes 0.000 claims 2
108010047761 Interferon-alpha Proteins 0.000 claims 2
241000124008 Mammalia Species 0.000 claims 2
241000700605 Viruses Species 0.000 claims 2
239000002253 acid Substances 0.000 claims 2
125000004442 acylamino group Chemical group 0.000 claims 2
125000003282 alkyl amino group Chemical group 0.000 claims 2
125000001769 aryl amino group Chemical group 0.000 claims 2
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 2
125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 claims 2
239000003795 chemical substances by application Substances 0.000 claims 2
125000004435 hydrogen atom Chemical group [H]* 0.000 claims 2
239000003112 inhibitor Substances 0.000 claims 2
125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 2
125000004430 oxygen atom Chemical group O* 0.000 claims 2
125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 2
125000003831 tetrazolyl group Chemical group 0.000 claims 2
125000005309 thioalkoxy group Chemical group 0.000 claims 2
125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 1
125000004607 1,2,3,4-tetrahydroquinolinyl group Chemical group N1(CCCC2=CC=CC=C12)* 0.000 claims 1
LPUCHTNHUHOTRY-UHFFFAOYSA-N 1-(3-bicyclo[2.2.1]heptanyl)ethanamine Chemical compound C1CC2C(C(N)C)CC1C2 LPUCHTNHUHOTRY-UHFFFAOYSA-N 0.000 claims 1
YEMLLQZLWMPTMG-UHFFFAOYSA-N 1-[1-cyclohexyl-2-(2-phenylquinolin-6-yl)benzimidazole-5-carbonyl]pyrrolidine-2-carboxylic acid Chemical compound OC(=O)C1CCCN1C(=O)C1=CC=C(N(C2CCCCC2)C(=N2)C=3C=C4C=CC(=NC4=CC=3)C=3C=CC=CC=3)C2=C1 YEMLLQZLWMPTMG-UHFFFAOYSA-N 0.000 claims 1
RUUUFOGMOOFEDK-UHFFFAOYSA-N 1-[1-cyclohexyl-2-(2-phenylquinoxalin-6-yl)benzimidazole-5-carbonyl]-4-hydroxypyrrolidine-2-carboxylic acid Chemical compound C1C(O)CC(C(O)=O)N1C(=O)C1=CC=C(N(C2CCCCC2)C(=N2)C=3C=C4N=CC(=NC4=CC=3)C=3C=CC=CC=3)C2=C1 RUUUFOGMOOFEDK-UHFFFAOYSA-N 0.000 claims 1
DJJCGMLRAHIQCC-UHFFFAOYSA-N 1-benzyl-2-[2-[2-(4-chlorophenyl)-5-methoxyphenyl]quinolin-6-yl]benzimidazole-5-carboxylic acid Chemical compound C=1C=C2C=C(C=3N(C4=CC=C(C=C4N=3)C(O)=O)CC=3C=CC=CC=3)C=CC2=NC=1C1=CC(OC)=CC=C1C1=CC=C(Cl)C=C1 DJJCGMLRAHIQCC-UHFFFAOYSA-N 0.000 claims 1
NHEPSLDHBMWDAO-UHFFFAOYSA-N 1-cyclohexyl-2-(2,3-diphenylquinolin-6-yl)benzimidazole-5-carboxylic acid Chemical compound C=1C=C2N=C(C=3C=CC=CC=3)C(C=3C=CC=CC=3)=CC2=CC=1C1=NC2=CC(C(=O)O)=CC=C2N1C1CCCCC1 NHEPSLDHBMWDAO-UHFFFAOYSA-N 0.000 claims 1
MWUGWQPFDUSOOT-UHFFFAOYSA-N 1-cyclohexyl-2-(2,3-diphenylquinoxalin-6-yl)benzimidazole-5-carboxylic acid Chemical compound C=1C=C2N=C(C=3C=CC=CC=3)C(C=3C=CC=CC=3)=NC2=CC=1C1=NC2=CC(C(=O)O)=CC=C2N1C1CCCCC1 MWUGWQPFDUSOOT-UHFFFAOYSA-N 0.000 claims 1
BKEZCCOADKFOCR-UHFFFAOYSA-N 1-cyclohexyl-2-(2-methyl-1,2,3,4-tetrahydroquinolin-6-yl)benzimidazole-5-carboxylic acid Chemical compound C=1C=C2NC(C)CCC2=CC=1C1=NC2=CC(C(O)=O)=CC=C2N1C1CCCCC1 BKEZCCOADKFOCR-UHFFFAOYSA-N 0.000 claims 1
XLNFHFKMFYNZGY-UHFFFAOYSA-N 1-cyclohexyl-2-(2-methyl-1,4-dioxo-3h-phthalazin-6-yl)benzimidazole-5-carboxylic acid Chemical compound C=1C=C2C(=O)N(C)NC(=O)C2=CC=1C1=NC2=CC(C(O)=O)=CC=C2N1C1CCCCC1 XLNFHFKMFYNZGY-UHFFFAOYSA-N 0.000 claims 1
QHFPRLMRIYREGF-UHFFFAOYSA-N 1-cyclohexyl-2-(2-methyl-4-oxo-1h-quinazolin-6-yl)benzimidazole-5-carboxylic acid Chemical compound C=1C=C2NC(C)=NC(=O)C2=CC=1C1=NC2=CC(C(O)=O)=CC=C2N1C1CCCCC1 QHFPRLMRIYREGF-UHFFFAOYSA-N 0.000 claims 1
NNCVVTDPHUUXOC-UHFFFAOYSA-N 1-cyclohexyl-2-(2-methyl-4-oxo-1h-quinolin-6-yl)benzimidazole-5-carboxylic acid Chemical compound C=1C=C2NC(C)=CC(=O)C2=CC=1C1=NC2=CC(C(O)=O)=CC=C2N1C1CCCCC1 NNCVVTDPHUUXOC-UHFFFAOYSA-N 0.000 claims 1
LUZRJYOSQAUAJJ-UHFFFAOYSA-N 1-cyclohexyl-2-(2-methylpteridin-6-yl)benzimidazole-5-carboxylic acid Chemical compound C1=NC2=NC(C)=NC=C2N=C1C1=NC2=CC(C(O)=O)=CC=C2N1C1CCCCC1 LUZRJYOSQAUAJJ-UHFFFAOYSA-N 0.000 claims 1
GCCQYSJCZLYXRE-UHFFFAOYSA-N 1-cyclohexyl-2-(2-methylquinazolin-7-yl)benzimidazole-5-carboxylic acid Chemical compound C=1C2=NC(C)=NC=C2C=CC=1C1=NC2=CC(C(O)=O)=CC=C2N1C1CCCCC1 GCCQYSJCZLYXRE-UHFFFAOYSA-N 0.000 claims 1
QINGQZBVZYPXED-UHFFFAOYSA-N 1-cyclohexyl-2-(2-methylquinoxalin-6-yl)benzimidazole-5-carboxylic acid Chemical compound C1=CC2=NC(C)=CN=C2C=C1C1=NC2=CC(C(O)=O)=CC=C2N1C1CCCCC1 QINGQZBVZYPXED-UHFFFAOYSA-N 0.000 claims 1
BFFWFDUCNNHBLM-UHFFFAOYSA-N 1-cyclohexyl-2-(2-naphthalen-1-ylquinolin-6-yl)benzimidazole-5-carboxylic acid Chemical compound C=1C=C2N=C(C=3C4=CC=CC=C4C=CC=3)C=CC2=CC=1C1=NC2=CC(C(=O)O)=CC=C2N1C1CCCCC1 BFFWFDUCNNHBLM-UHFFFAOYSA-N 0.000 claims 1
YIGJZGQXEPUOHT-UHFFFAOYSA-N 1-cyclohexyl-2-(2-phenyl-1,2,3,4-tetrahydroquinolin-6-yl)benzimidazole-5-carboxylic acid Chemical compound C=1C=C2NC(C=3C=CC=CC=3)CCC2=CC=1C1=NC2=CC(C(=O)O)=CC=C2N1C1CCCCC1 YIGJZGQXEPUOHT-UHFFFAOYSA-N 0.000 claims 1
AGMJEUKGERIOFO-UHFFFAOYSA-N 1-cyclohexyl-2-(2-phenyl-4-phenylsulfanylquinolin-6-yl)benzimidazole-5-carboxylic acid Chemical compound C=1C=C2N=C(C=3C=CC=CC=3)C=C(SC=3C=CC=CC=3)C2=CC=1C1=NC2=CC(C(=O)O)=CC=C2N1C1CCCCC1 AGMJEUKGERIOFO-UHFFFAOYSA-N 0.000 claims 1
BAXYSNSVMGVGTR-UHFFFAOYSA-N 1-cyclohexyl-2-(2-phenylpteridin-6-yl)benzimidazole-5-carboxylic acid Chemical compound C=1N=C2N=C(C=3C=CC=CC=3)N=CC2=NC=1C1=NC2=CC(C(=O)O)=CC=C2N1C1CCCCC1 BAXYSNSVMGVGTR-UHFFFAOYSA-N 0.000 claims 1
FDRMCXWFFVOAMI-UHFFFAOYSA-N 1-cyclohexyl-2-(2-phenylquinolin-6-yl)benzimidazole-5-carboxylic acid Chemical compound C=1C=C2N=C(C=3C=CC=CC=3)C=CC2=CC=1C1=NC2=CC(C(=O)O)=CC=C2N1C1CCCCC1 FDRMCXWFFVOAMI-UHFFFAOYSA-N 0.000 claims 1
YRPUXWOLRWZMTF-UHFFFAOYSA-N 1-cyclohexyl-2-(2-phenylquinolin-7-yl)benzimidazole-5-carboxylic acid Chemical compound C=1C=C2C=CC(C=3C=CC=CC=3)=NC2=CC=1C1=NC2=CC(C(=O)O)=CC=C2N1C1CCCCC1 YRPUXWOLRWZMTF-UHFFFAOYSA-N 0.000 claims 1
LDWRUZMBTZIKDC-UHFFFAOYSA-N 1-cyclohexyl-2-(2-phenylquinoxalin-6-yl)benzimidazole-5-carboxylic acid Chemical compound C=1C=C2N=C(C=3C=CC=CC=3)C=NC2=CC=1C1=NC2=CC(C(=O)O)=CC=C2N1C1CCCCC1 LDWRUZMBTZIKDC-UHFFFAOYSA-N 0.000 claims 1
CJRUPMHYWMLNFK-UHFFFAOYSA-N 1-cyclohexyl-2-(2-pyrazin-2-ylquinolin-6-yl)benzimidazole-5-carboxylic acid Chemical compound C=1C=C2N=C(C=3N=CC=NC=3)C=CC2=CC=1C1=NC2=CC(C(=O)O)=CC=C2N1C1CCCCC1 CJRUPMHYWMLNFK-UHFFFAOYSA-N 0.000 claims 1
XHUHIJYTJMRJSJ-UHFFFAOYSA-N 1-cyclohexyl-2-(2-pyridin-2-ylquinolin-6-yl)benzimidazole-5-carboxylic acid Chemical compound C=1C=C2N=C(C=3N=CC=CC=3)C=CC2=CC=1C1=NC2=CC(C(=O)O)=CC=C2N1C1CCCCC1 XHUHIJYTJMRJSJ-UHFFFAOYSA-N 0.000 claims 1
AVLVLGZBTZKDNH-UHFFFAOYSA-N 1-cyclohexyl-2-(2-pyridin-3-ylquinolin-6-yl)benzimidazole-5-carboxylic acid Chemical compound C=1C=C2N=C(C=3C=NC=CC=3)C=CC2=CC=1C1=NC2=CC(C(=O)O)=CC=C2N1C1CCCCC1 AVLVLGZBTZKDNH-UHFFFAOYSA-N 0.000 claims 1
QWVWRQJNZQGTCG-UHFFFAOYSA-N 1-cyclohexyl-2-(2-pyridin-4-ylquinolin-6-yl)benzimidazole-5-carboxylic acid Chemical compound C=1C=C2N=C(C=3C=CN=CC=3)C=CC2=CC=1C1=NC2=CC(C(=O)O)=CC=C2N1C1CCCCC1 QWVWRQJNZQGTCG-UHFFFAOYSA-N 0.000 claims 1
HDEDCYJUSACBMY-UHFFFAOYSA-N 1-cyclohexyl-2-(3-methyl-1,1-dioxo-4h-1$l^{6},2,4-benzothiadiazin-7-yl)benzimidazole-5-carboxylic acid Chemical compound C=1C=C2NC(C)=NS(=O)(=O)C2=CC=1C1=NC2=CC(C(O)=O)=CC=C2N1C1CCCCC1 HDEDCYJUSACBMY-UHFFFAOYSA-N 0.000 claims 1
VQCZWKZLWPOCKI-UHFFFAOYSA-N 1-cyclohexyl-2-(3-methyl-1,4-dihydroisoquinolin-6-yl)benzimidazole-5-carboxylic acid Chemical compound C1=C2CC(C)=NCC2=CC=C1C1=NC2=CC(C(O)=O)=CC=C2N1C1CCCCC1 VQCZWKZLWPOCKI-UHFFFAOYSA-N 0.000 claims 1
IUEGGNZKOORHIH-UHFFFAOYSA-N 1-cyclohexyl-2-(3-methyl-4-oxochromen-6-yl)benzimidazole-5-carboxylic acid Chemical compound C1=C2C(=O)C(C)=COC2=CC=C1C1=NC2=CC(C(O)=O)=CC=C2N1C1CCCCC1 IUEGGNZKOORHIH-UHFFFAOYSA-N 0.000 claims 1
XBODRDHVIXGBBS-UHFFFAOYSA-N 1-cyclohexyl-2-(3-methyl-4-oxochromen-7-yl)benzimidazole-5-carboxylic acid Chemical compound C=1C=C2C(=O)C(C)=COC2=CC=1C1=NC2=CC(C(O)=O)=CC=C2N1C1CCCCC1 XBODRDHVIXGBBS-UHFFFAOYSA-N 0.000 claims 1
POUXUAXTEPKLGT-UHFFFAOYSA-N 1-cyclohexyl-2-(3-methylisoquinolin-6-yl)benzimidazole-5-carboxylic acid Chemical compound C=1C=C2C=NC(C)=CC2=CC=1C1=NC2=CC(C(O)=O)=CC=C2N1C1CCCCC1 POUXUAXTEPKLGT-UHFFFAOYSA-N 0.000 claims 1
XMXHJRXCXZFBAK-UHFFFAOYSA-N 1-cyclohexyl-2-(3-phenylquinolin-6-yl)benzimidazole-5-carboxylic acid Chemical compound C=1C=C2N=CC(C=3C=CC=CC=3)=CC2=CC=1C1=NC2=CC(C(=O)O)=CC=C2N1C1CCCCC1 XMXHJRXCXZFBAK-UHFFFAOYSA-N 0.000 claims 1
OFKYLJUCSZOGCA-UHFFFAOYSA-N 1-cyclohexyl-2-(3-phenylquinolin-7-yl)benzimidazole-5-carboxylic acid Chemical compound C=1C=C2C=C(C=3C=CC=CC=3)C=NC2=CC=1C1=NC2=CC(C(=O)O)=CC=C2N1C1CCCCC1 OFKYLJUCSZOGCA-UHFFFAOYSA-N 0.000 claims 1
OCYWAAMZOKEANA-UHFFFAOYSA-N 1-cyclohexyl-2-(3-phenylquinoxalin-6-yl)benzimidazole-5-carboxylic acid Chemical compound C=1C=C2N=CC(C=3C=CC=CC=3)=NC2=CC=1C1=NC2=CC(C(=O)O)=CC=C2N1C1CCCCC1 OCYWAAMZOKEANA-UHFFFAOYSA-N 0.000 claims 1
DCDQRNCKAMYTFW-UHFFFAOYSA-N 1-cyclohexyl-2-(4-ethoxy-2-phenylquinolin-6-yl)benzimidazole-5-carboxylic acid Chemical compound C1=C2C(OCC)=CC(C=3C=CC=CC=3)=NC2=CC=C1C1=NC2=CC(C(O)=O)=CC=C2N1C1CCCCC1 DCDQRNCKAMYTFW-UHFFFAOYSA-N 0.000 claims 1
ZLCTXYNEUASXSM-UHFFFAOYSA-N 1-cyclohexyl-2-(4-hydrazinyl-2-phenylquinolin-6-yl)benzimidazole-5-carboxylic acid Chemical compound C1=C2C(NN)=CC(C=3C=CC=CC=3)=NC2=CC=C1C1=NC2=CC(C(O)=O)=CC=C2N1C1CCCCC1 ZLCTXYNEUASXSM-UHFFFAOYSA-N 0.000 claims 1
ICKCPOUWXDQGNO-UHFFFAOYSA-N 1-cyclohexyl-2-(4-methyl-2-phenylquinolin-6-yl)benzimidazole-5-carboxylic acid Chemical compound C1=C2C(C)=CC(C=3C=CC=CC=3)=NC2=CC=C1C1=NC2=CC(C(O)=O)=CC=C2N1C1CCCCC1 ICKCPOUWXDQGNO-UHFFFAOYSA-N 0.000 claims 1
CGVUVLGXWKXIKS-UHFFFAOYSA-N 1-cyclohexyl-2-(4-oxo-2-phenyl-1h-quinolin-6-yl)benzimidazole-5-carboxylic acid Chemical compound C=1C=C2NC(C=3C=CC=CC=3)=CC(=O)C2=CC=1C1=NC2=CC(C(=O)O)=CC=C2N1C1CCCCC1 CGVUVLGXWKXIKS-UHFFFAOYSA-N 0.000 claims 1
ZHIJYZWIFQSILF-UHFFFAOYSA-N 1-cyclohexyl-2-(4-oxo-2-phenylchromen-6-yl)benzimidazole-5-carboxylic acid Chemical compound C=1C=C2OC(C=3C=CC=CC=3)=CC(=O)C2=CC=1C1=NC2=CC(C(=O)O)=CC=C2N1C1CCCCC1 ZHIJYZWIFQSILF-UHFFFAOYSA-N 0.000 claims 1
RNBCXMDMCQKWHS-UHFFFAOYSA-N 1-cyclohexyl-2-(4-phenoxy-2-phenylquinolin-6-yl)benzimidazole-5-carboxylic acid Chemical compound C=1C=C2N=C(C=3C=CC=CC=3)C=C(OC=3C=CC=CC=3)C2=CC=1C1=NC2=CC(C(=O)O)=CC=C2N1C1CCCCC1 RNBCXMDMCQKWHS-UHFFFAOYSA-N 0.000 claims 1
ADXKVUAMSDKDSD-UHFFFAOYSA-N 1-cyclohexyl-2-(6-methyl-1,5-naphthyridin-2-yl)benzimidazole-5-carboxylic acid Chemical compound C1=CC2=NC(C)=CC=C2N=C1C1=NC2=CC(C(O)=O)=CC=C2N1C1CCCCC1 ADXKVUAMSDKDSD-UHFFFAOYSA-N 0.000 claims 1
DKEFQEQWTNDNNV-UHFFFAOYSA-N 1-cyclohexyl-2-(6-methyl-1,8-naphthyridin-3-yl)benzimidazole-5-carboxylic acid Chemical compound C=1C2=CC(C)=CN=C2N=CC=1C1=NC2=CC(C(O)=O)=CC=C2N1C1CCCCC1 DKEFQEQWTNDNNV-UHFFFAOYSA-N 0.000 claims 1
UCPAWBWTMAABES-UHFFFAOYSA-N 1-cyclohexyl-2-(6-phenyl-1,8-naphthyridin-3-yl)benzimidazole-5-carboxylic acid Chemical compound C=1N=C2N=CC(C=3C=CC=CC=3)=CC2=CC=1C1=NC2=CC(C(=O)O)=CC=C2N1C1CCCCC1 UCPAWBWTMAABES-UHFFFAOYSA-N 0.000 claims 1
SUBQECRWKXEZEM-UHFFFAOYSA-N 1-cyclohexyl-2-(7-methyl-1,8-naphthyridin-3-yl)benzimidazole-5-carboxylic acid Chemical compound C1=NC2=NC(C)=CC=C2C=C1C1=NC2=CC(C(O)=O)=CC=C2N1C1CCCCC1 SUBQECRWKXEZEM-UHFFFAOYSA-N 0.000 claims 1
LDPQWIJJGHMNTE-UHFFFAOYSA-N 1-cyclohexyl-2-(7-methylcinnolin-3-yl)benzimidazole-5-carboxylic acid Chemical compound N1=NC2=CC(C)=CC=C2C=C1C1=NC2=CC(C(O)=O)=CC=C2N1C1CCCCC1 LDPQWIJJGHMNTE-UHFFFAOYSA-N 0.000 claims 1
ZRDWVIXETQVBCJ-UHFFFAOYSA-N 1-cyclohexyl-2-(7-phenyl-1,8-naphthyridin-3-yl)benzimidazole-5-carboxylic acid Chemical compound C=1N=C2N=C(C=3C=CC=CC=3)C=CC2=CC=1C1=NC2=CC(C(=O)O)=CC=C2N1C1CCCCC1 ZRDWVIXETQVBCJ-UHFFFAOYSA-N 0.000 claims 1
LXUIQUOMODHWDA-UHFFFAOYSA-N 1-cyclohexyl-2-(7-phenylcinnolin-3-yl)benzimidazole-5-carboxylic acid Chemical compound C=1C2=CC=C(C=3C=CC=CC=3)C=C2N=NC=1C1=NC2=CC(C(=O)O)=CC=C2N1C1CCCCC1 LXUIQUOMODHWDA-UHFFFAOYSA-N 0.000 claims 1
ZHGMJGQQHROZEQ-UHFFFAOYSA-N 1-cyclohexyl-2-(8-methyl-2-phenylquinolin-6-yl)benzimidazole-5-carboxylic acid Chemical compound N1=C2C(C)=CC(C=3N(C4=CC=C(C=C4N=3)C(O)=O)C3CCCCC3)=CC2=CC=C1C1=CC=CC=C1 ZHGMJGQQHROZEQ-UHFFFAOYSA-N 0.000 claims 1
DBYOKZIKCLNGOX-UHFFFAOYSA-N 1-cyclohexyl-2-[2-(1-phenylpyrazol-4-yl)quinolin-6-yl]benzimidazole-5-carboxylic acid Chemical compound C=1C=C2N=C(C3=CN(N=C3)C=3C=CC=CC=3)C=CC2=CC=1C1=NC2=CC(C(=O)O)=CC=C2N1C1CCCCC1 DBYOKZIKCLNGOX-UHFFFAOYSA-N 0.000 claims 1
GCZXYNJBRRHEFL-UHFFFAOYSA-N 1-cyclohexyl-2-[2-(1h-pyrrol-2-yl)quinolin-6-yl]benzimidazole-5-carboxylic acid Chemical compound C=1C=C2N=C(C=3NC=CC=3)C=CC2=CC=1C1=NC2=CC(C(=O)O)=CC=C2N1C1CCCCC1 GCZXYNJBRRHEFL-UHFFFAOYSA-N 0.000 claims 1
IMXABVBXRCQCCL-UHFFFAOYSA-N 1-cyclohexyl-2-[2-(1h-pyrrol-3-yl)quinolin-6-yl]benzimidazole-5-carboxylic acid Chemical compound C=1C=C2N=C(C3=CNC=C3)C=CC2=CC=1C1=NC2=CC(C(=O)O)=CC=C2N1C1CCCCC1 IMXABVBXRCQCCL-UHFFFAOYSA-N 0.000 claims 1
XHTWDSSRACSPOY-UHFFFAOYSA-N 1-cyclohexyl-2-[2-(2,3-dihydro-1-benzofuran-5-yl)quinolin-6-yl]benzimidazole-5-carboxylic acid Chemical compound C=1C=C2N=C(C=3C=C4CCOC4=CC=3)C=CC2=CC=1C1=NC2=CC(C(=O)O)=CC=C2N1C1CCCCC1 XHTWDSSRACSPOY-UHFFFAOYSA-N 0.000 claims 1
AWUOFHKEIYORIK-UHFFFAOYSA-N 1-cyclohexyl-2-[2-(2,4-dimethyl-1,3-thiazol-5-yl)quinolin-6-yl]benzimidazole-5-carboxylic acid Chemical compound S1C(C)=NC(C)=C1C1=CC=C(C=C(C=C2)C=3N(C4=CC=C(C=C4N=3)C(O)=O)C3CCCCC3)C2=N1 AWUOFHKEIYORIK-UHFFFAOYSA-N 0.000 claims 1
JBOCJZGEMGJVDL-UHFFFAOYSA-N 1-cyclohexyl-2-[2-(2-cyclohexyl-5-methoxyphenyl)quinolin-6-yl]benzimidazole-5-carboxylic acid Chemical compound C=1C=C2C=C(C=3N(C4=CC=C(C=C4N=3)C(O)=O)C3CCCCC3)C=CC2=NC=1C1=CC(OC)=CC=C1C1CCCCC1 JBOCJZGEMGJVDL-UHFFFAOYSA-N 0.000 claims 1
HBOCROPDYWXGHZ-UHFFFAOYSA-N 1-cyclohexyl-2-[2-(2-ethoxy-5-nitrophenyl)quinolin-6-yl]benzimidazole-5-carboxylic acid Chemical compound CCOC1=CC=C([N+]([O-])=O)C=C1C1=CC=C(C=C(C=C2)C=3N(C4=CC=C(C=C4N=3)C(O)=O)C3CCCCC3)C2=N1 HBOCROPDYWXGHZ-UHFFFAOYSA-N 0.000 claims 1
MXISMJBBFNIFLP-UHFFFAOYSA-N 1-cyclohexyl-2-[2-(2-methyl-5-phenylmethoxy-1-benzofuran-3-yl)quinolin-6-yl]benzimidazole-5-carboxylic acid Chemical compound C1=C2C(C=3N=C4C=CC(=CC4=CC=3)C=3N(C4=CC=C(C=C4N=3)C(O)=O)C3CCCCC3)=C(C)OC2=CC=C1OCC1=CC=CC=C1 MXISMJBBFNIFLP-UHFFFAOYSA-N 0.000 claims 1
SQMUJHTVYNJDFL-UHFFFAOYSA-N 1-cyclohexyl-2-[2-(2-pyrazol-1-ylethyl)quinolin-6-yl]benzimidazole-5-carboxylic acid Chemical compound C=1C=C2N=C(CCN3N=CC=C3)C=CC2=CC=1C1=NC2=CC(C(=O)O)=CC=C2N1C1CCCCC1 SQMUJHTVYNJDFL-UHFFFAOYSA-N 0.000 claims 1
FIPKAQDSCSKXSJ-UHFFFAOYSA-N 1-cyclohexyl-2-[2-(2-pyridin-4-ylphenyl)quinolin-6-yl]benzimidazole-5-carboxylic acid Chemical compound C=1C=C2N=C(C=3C(=CC=CC=3)C=3C=CN=CC=3)C=CC2=CC=1C1=NC2=CC(C(=O)O)=CC=C2N1C1CCCCC1 FIPKAQDSCSKXSJ-UHFFFAOYSA-N 0.000 claims 1
VJNRFZCPZJIOQA-UHFFFAOYSA-N 1-cyclohexyl-2-[2-(3,4-dichlorophenyl)quinolin-6-yl]benzimidazole-5-carboxylic acid Chemical compound C=1C=C2N=C(C=3C=C(Cl)C(Cl)=CC=3)C=CC2=CC=1C1=NC2=CC(C(=O)O)=CC=C2N1C1CCCCC1 VJNRFZCPZJIOQA-UHFFFAOYSA-N 0.000 claims 1
UFLYVBSXOZQVEK-UHFFFAOYSA-N 1-cyclohexyl-2-[2-(3,5-dihydroxyphenyl)quinolin-6-yl]benzimidazole-5-carboxylic acid Chemical compound C=1C=C2N=C(C=3C=C(O)C=C(O)C=3)C=CC2=CC=1C1=NC2=CC(C(=O)O)=CC=C2N1C1CCCCC1 UFLYVBSXOZQVEK-UHFFFAOYSA-N 0.000 claims 1
LNWFURDURQVASY-UHFFFAOYSA-N 1-cyclohexyl-2-[2-(3,5-dimethoxyphenyl)quinolin-6-yl]benzimidazole-5-carboxylic acid Chemical compound COC1=CC(OC)=CC(C=2N=C3C=CC(=CC3=CC=2)C=2N(C3=CC=C(C=C3N=2)C(O)=O)C2CCCCC2)=C1 LNWFURDURQVASY-UHFFFAOYSA-N 0.000 claims 1
HBSBURLDWICCQF-UHFFFAOYSA-N 1-cyclohexyl-2-[2-(3,5-dimethyl-1-phenylpyrazol-4-yl)quinolin-6-yl]benzimidazole-5-carboxylic acid Chemical compound CC1=NN(C=2C=CC=CC=2)C(C)=C1C(N=C1C=C2)=CC=C1C=C2C1=NC2=CC(C(O)=O)=CC=C2N1C1CCCCC1 HBSBURLDWICCQF-UHFFFAOYSA-N 0.000 claims 1
IMIJNLMRPIXNRD-UHFFFAOYSA-N 1-cyclohexyl-2-[2-(3-hydroxyphenyl)quinolin-6-yl]benzimidazole-5-carboxylic acid Chemical compound C=1C=C2N=C(C=3C=C(O)C=CC=3)C=CC2=CC=1C1=NC2=CC(C(=O)O)=CC=C2N1C1CCCCC1 IMIJNLMRPIXNRD-UHFFFAOYSA-N 0.000 claims 1
AZHJJBXSNLQZGO-UHFFFAOYSA-N 1-cyclohexyl-2-[2-(3-hydroxypropyl)quinolin-6-yl]benzimidazole-5-carboxylic acid Chemical compound C1=CC2=NC(CCCO)=CC=C2C=C1C1=NC2=CC(C(O)=O)=CC=C2N1C1CCCCC1 AZHJJBXSNLQZGO-UHFFFAOYSA-N 0.000 claims 1
MCAKSIOVTWYEQX-UHFFFAOYSA-N 1-cyclohexyl-2-[2-(3-methoxyphenyl)quinolin-6-yl]benzimidazole-5-carboxylic acid Chemical compound COC1=CC=CC(C=2N=C3C=CC(=CC3=CC=2)C=2N(C3=CC=C(C=C3N=2)C(O)=O)C2CCCCC2)=C1 MCAKSIOVTWYEQX-UHFFFAOYSA-N 0.000 claims 1
WUKWLAOMHRWCOT-UHFFFAOYSA-N 1-cyclohexyl-2-[2-(4-imidazol-1-ylphenyl)quinolin-6-yl]benzimidazole-5-carboxylic acid Chemical compound C=1C=C2N=C(C=3C=CC(=CC=3)N3C=NC=C3)C=CC2=CC=1C1=NC2=CC(C(=O)O)=CC=C2N1C1CCCCC1 WUKWLAOMHRWCOT-UHFFFAOYSA-N 0.000 claims 1
VULQLJVXHIDRHI-UHFFFAOYSA-N 1-cyclohexyl-2-[2-(4-morpholin-4-ylphenyl)quinolin-6-yl]benzimidazole-5-carboxylic acid Chemical compound C=1C=C2N=C(C=3C=CC(=CC=3)N3CCOCC3)C=CC2=CC=1C1=NC2=CC(C(=O)O)=CC=C2N1C1CCCCC1 VULQLJVXHIDRHI-UHFFFAOYSA-N 0.000 claims 1
PJDANKKKQOCTIA-UHFFFAOYSA-N 1-cyclohexyl-2-[2-(4-piperazin-1-ylphenyl)quinolin-6-yl]benzimidazole-5-carboxylic acid Chemical compound C=1C=C2N=C(C=3C=CC(=CC=3)N3CCNCC3)C=CC2=CC=1C1=NC2=CC(C(=O)O)=CC=C2N1C1CCCCC1 PJDANKKKQOCTIA-UHFFFAOYSA-N 0.000 claims 1
SZVUWRWTEMALQL-UHFFFAOYSA-N 1-cyclohexyl-2-[2-(5,6,7,8-tetrahydronaphthalen-2-yl)quinolin-6-yl]benzimidazole-5-carboxylic acid Chemical compound C=1C=C2N=C(C=3C=C4CCCCC4=CC=3)C=CC2=CC=1C1=NC2=CC(C(=O)O)=CC=C2N1C1CCCCC1 SZVUWRWTEMALQL-UHFFFAOYSA-N 0.000 claims 1
AMRBKIOQNUPQCI-UHFFFAOYSA-N 1-cyclohexyl-2-[2-(5-hydroxy-2-phenylphenyl)quinolin-6-yl]benzimidazole-5-carboxylic acid Chemical compound C=1C=C2N=C(C=3C(=CC=C(O)C=3)C=3C=CC=CC=3)C=CC2=CC=1C1=NC2=CC(C(=O)O)=CC=C2N1C1CCCCC1 AMRBKIOQNUPQCI-UHFFFAOYSA-N 0.000 claims 1
MAVIXOPVPVATPQ-UHFFFAOYSA-N 1-cyclohexyl-2-[2-(5-methoxy-1-benzofuran-3-yl)quinolin-6-yl]benzimidazole-5-carboxylic acid Chemical compound C12=CC(OC)=CC=C2OC=C1C(N=C1C=C2)=CC=C1C=C2C1=NC2=CC(C(O)=O)=CC=C2N1C1CCCCC1 MAVIXOPVPVATPQ-UHFFFAOYSA-N 0.000 claims 1
LHGLCHFDOASWBG-UHFFFAOYSA-N 1-cyclohexyl-2-[2-(5-methoxy-2-phenylphenyl)quinolin-6-yl]benzimidazole-5-carboxylic acid Chemical compound C=1C=C2C=C(C=3N(C4=CC=C(C=C4N=3)C(O)=O)C3CCCCC3)C=CC2=NC=1C1=CC(OC)=CC=C1C1=CC=CC=C1 LHGLCHFDOASWBG-UHFFFAOYSA-N 0.000 claims 1
AWTCHNXQTODERK-UHFFFAOYSA-N 1-cyclohexyl-2-[2-(5-methoxy-2-thiophen-2-ylphenyl)quinolin-6-yl]benzimidazole-5-carboxylic acid Chemical compound C=1C=C2C=C(C=3N(C4=CC=C(C=C4N=3)C(O)=O)C3CCCCC3)C=CC2=NC=1C1=CC(OC)=CC=C1C1=CC=CS1 AWTCHNXQTODERK-UHFFFAOYSA-N 0.000 claims 1
IOJZGAAHYQGJBH-UHFFFAOYSA-N 1-cyclohexyl-2-[2-(5-methyl-2-phenylthiophen-3-yl)quinolin-6-yl]benzimidazole-5-carboxylic acid Chemical compound S1C(C)=CC(C=2N=C3C=CC(=CC3=CC=2)C=2N(C3=CC=C(C=C3N=2)C(O)=O)C2CCCCC2)=C1C1=CC=CC=C1 IOJZGAAHYQGJBH-UHFFFAOYSA-N 0.000 claims 1
RWSGBQDPRUWNIZ-UHFFFAOYSA-N 1-cyclohexyl-2-[2-[(dipropylamino)methyl]quinolin-6-yl]benzimidazole-5-carboxylic acid Chemical compound C1=CC2=NC(CN(CCC)CCC)=CC=C2C=C1C1=NC2=CC(C(O)=O)=CC=C2N1C1CCCCC1 RWSGBQDPRUWNIZ-UHFFFAOYSA-N 0.000 claims 1
MBPRXBKZKIMYCD-UHFFFAOYSA-N 1-cyclohexyl-2-[2-[2-(2,4-dimethoxypyrimidin-5-yl)-5-methoxyphenyl]quinolin-6-yl]benzimidazole-5-carboxylic acid Chemical compound C=1C=C2C=C(C=3N(C4=CC=C(C=C4N=3)C(O)=O)C3CCCCC3)C=CC2=NC=1C1=CC(OC)=CC=C1C1=CN=C(OC)N=C1OC MBPRXBKZKIMYCD-UHFFFAOYSA-N 0.000 claims 1
VQUKSGYQFFXFBW-UHFFFAOYSA-N 1-cyclohexyl-2-[2-[2-(2-fluorophenyl)-5-methoxyphenyl]quinolin-6-yl]benzimidazole-5-carboxylic acid Chemical compound C=1C=C2C=C(C=3N(C4=CC=C(C=C4N=3)C(O)=O)C3CCCCC3)C=CC2=NC=1C1=CC(OC)=CC=C1C1=CC=CC=C1F VQUKSGYQFFXFBW-UHFFFAOYSA-N 0.000 claims 1
JTKAHVDANGQAKL-UHFFFAOYSA-N 1-cyclohexyl-2-[2-[2-(3,4-dichlorophenyl)-5-methoxyphenyl]quinolin-6-yl]benzimidazole-5-carboxylic acid Chemical compound C=1C=C2C=C(C=3N(C4=CC=C(C=C4N=3)C(O)=O)C3CCCCC3)C=CC2=NC=1C1=CC(OC)=CC=C1C1=CC=C(Cl)C(Cl)=C1 JTKAHVDANGQAKL-UHFFFAOYSA-N 0.000 claims 1
RUHSIIWGFOTUQV-UHFFFAOYSA-N 1-cyclohexyl-2-[2-[2-(3,4-difluorophenyl)-5-methoxyphenyl]quinolin-6-yl]benzimidazole-5-carboxylic acid Chemical compound C=1C=C2C=C(C=3N(C4=CC=C(C=C4N=3)C(O)=O)C3CCCCC3)C=CC2=NC=1C1=CC(OC)=CC=C1C1=CC=C(F)C(F)=C1 RUHSIIWGFOTUQV-UHFFFAOYSA-N 0.000 claims 1
LUOUUDSRCXPXJZ-UHFFFAOYSA-N 1-cyclohexyl-2-[2-[2-(3,4-dimethoxyphenyl)-5-(pyrrolidine-1-carbonyl)phenyl]quinolin-6-yl]benzimidazole-5-carboxylic acid Chemical compound C1=C(OC)C(OC)=CC=C1C1=CC=C(C(=O)N2CCCC2)C=C1C1=CC=C(C=C(C=C2)C=3N(C4=CC=C(C=C4N=3)C(O)=O)C3CCCCC3)C2=N1 LUOUUDSRCXPXJZ-UHFFFAOYSA-N 0.000 claims 1
JNLJSPFIOSMGKQ-UHFFFAOYSA-N 1-cyclohexyl-2-[2-[2-(3,5-dichlorophenyl)-5-methoxyphenyl]quinolin-6-yl]benzimidazole-5-carboxylic acid Chemical compound C=1C=C2C=C(C=3N(C4=CC=C(C=C4N=3)C(O)=O)C3CCCCC3)C=CC2=NC=1C1=CC(OC)=CC=C1C1=CC(Cl)=CC(Cl)=C1 JNLJSPFIOSMGKQ-UHFFFAOYSA-N 0.000 claims 1
ORACTQNRGCZUTM-UHFFFAOYSA-N 1-cyclohexyl-2-[2-[2-(4-ethoxyphenyl)-5-methoxyphenyl]quinolin-6-yl]benzimidazole-5-carboxylic acid Chemical compound C1=CC(OCC)=CC=C1C1=CC=C(OC)C=C1C1=CC=C(C=C(C=C2)C=3N(C4=CC=C(C=C4N=3)C(O)=O)C3CCCCC3)C2=N1 ORACTQNRGCZUTM-UHFFFAOYSA-N 0.000 claims 1
DQAFEIRASMXMJE-UHFFFAOYSA-N 1-cyclohexyl-2-[2-[2-(4-ethylphenyl)-5-methoxyphenyl]quinolin-6-yl]benzimidazole-5-carboxylic acid Chemical compound C1=CC(CC)=CC=C1C1=CC=C(OC)C=C1C1=CC=C(C=C(C=C2)C=3N(C4=CC=C(C=C4N=3)C(O)=O)C3CCCCC3)C2=N1 DQAFEIRASMXMJE-UHFFFAOYSA-N 0.000 claims 1
XZNVLQZHZJWJRW-UHFFFAOYSA-N 1-cyclohexyl-2-[2-[2-(4-fluorophenyl)-5-(pyrrolidine-1-carbonyl)phenyl]quinolin-6-yl]benzimidazole-5-carboxylic acid Chemical compound C=1C=C2N=C(C=3C(=CC=C(C=3)C(=O)N3CCCC3)C=3C=CC(F)=CC=3)C=CC2=CC=1C1=NC2=CC(C(=O)O)=CC=C2N1C1CCCCC1 XZNVLQZHZJWJRW-UHFFFAOYSA-N 0.000 claims 1
ZZXJUFHHGWHOMP-UHFFFAOYSA-N 1-cyclohexyl-2-[2-[2-(4-fluorophenyl)-5-methoxyphenyl]quinolin-6-yl]benzimidazole-5-carboxamide Chemical compound C=1C=C2C=C(C=3N(C4=CC=C(C=C4N=3)C(N)=O)C3CCCCC3)C=CC2=NC=1C1=CC(OC)=CC=C1C1=CC=C(F)C=C1 ZZXJUFHHGWHOMP-UHFFFAOYSA-N 0.000 claims 1
ZZTCUKBHWQFCBK-UHFFFAOYSA-N 1-cyclohexyl-2-[2-[2-(4-methoxyphenyl)-5-(pyrrolidine-1-carbonyl)phenyl]quinolin-6-yl]benzimidazole-5-carboxylic acid Chemical compound C1=CC(OC)=CC=C1C1=CC=C(C(=O)N2CCCC2)C=C1C1=CC=C(C=C(C=C2)C=3N(C4=CC=C(C=C4N=3)C(O)=O)C3CCCCC3)C2=N1 ZZTCUKBHWQFCBK-UHFFFAOYSA-N 0.000 claims 1
SVHHYBQFZUXBEG-UHFFFAOYSA-N 1-cyclohexyl-2-[2-[2-(4-nitrophenyl)-5-(pyrrolidine-1-carbonyl)phenyl]quinolin-6-yl]benzimidazole-5-carboxylic acid Chemical compound C=1C=C2N=C(C=3C(=CC=C(C=3)C(=O)N3CCCC3)C=3C=CC(=CC=3)[N+]([O-])=O)C=CC2=CC=1C1=NC2=CC(C(=O)O)=CC=C2N1C1CCCCC1 SVHHYBQFZUXBEG-UHFFFAOYSA-N 0.000 claims 1
MKIJOSAPYWOOBL-UHFFFAOYSA-N 1-cyclohexyl-2-[2-[2-(furan-2-yl)-5-methoxyphenyl]quinolin-6-yl]benzimidazole-5-carboxylic acid Chemical compound C=1C=C2C=C(C=3N(C4=CC=C(C=C4N=3)C(O)=O)C3CCCCC3)C=CC2=NC=1C1=CC(OC)=CC=C1C1=CC=CO1 MKIJOSAPYWOOBL-UHFFFAOYSA-N 0.000 claims 1
TWZZKFUJUYTFOJ-UHFFFAOYSA-N 1-cyclohexyl-2-[2-[2-[4-(dimethylamino)phenyl]-5-methoxyphenyl]quinolin-6-yl]benzimidazole-5-carboxylic acid Chemical compound C=1C=C2C=C(C=3N(C4=CC=C(C=C4N=3)C(O)=O)C3CCCCC3)C=CC2=NC=1C1=CC(OC)=CC=C1C1=CC=C(N(C)C)C=C1 TWZZKFUJUYTFOJ-UHFFFAOYSA-N 0.000 claims 1
SATRBIYGMBJKBQ-UHFFFAOYSA-N 1-cyclohexyl-2-[2-[2-phenyl-5-(3-pyrrolidin-1-ylpropoxy)phenyl]quinolin-6-yl]benzimidazole-5-carboxylic acid Chemical compound C=1C=C2N=C(C=3C(=CC=C(OCCCN4CCCC4)C=3)C=3C=CC=CC=3)C=CC2=CC=1C1=NC2=CC(C(=O)O)=CC=C2N1C1CCCCC1 SATRBIYGMBJKBQ-UHFFFAOYSA-N 0.000 claims 1
VUARPOCKJGFXGY-UHFFFAOYSA-N 1-cyclohexyl-2-[2-[3-(2-methoxyethoxy)phenyl]quinolin-6-yl]benzimidazole-5-carboxylic acid Chemical compound COCCOC1=CC=CC(C=2N=C3C=CC(=CC3=CC=2)C=2N(C3=CC=C(C=C3N=2)C(O)=O)C2CCCCC2)=C1 VUARPOCKJGFXGY-UHFFFAOYSA-N 0.000 claims 1
GOHVOALGKHJIJT-UHFFFAOYSA-N 1-cyclohexyl-2-[2-[3-(2-oxo-2-pyrrolidin-1-ylethoxy)phenyl]quinolin-6-yl]benzimidazole-5-carboxylic acid Chemical compound C=1C=C2N=C(C=3C=C(OCC(=O)N4CCCC4)C=CC=3)C=CC2=CC=1C1=NC2=CC(C(=O)O)=CC=C2N1C1CCCCC1 GOHVOALGKHJIJT-UHFFFAOYSA-N 0.000 claims 1
TXJUUJQUIXQGFK-UHFFFAOYSA-N 1-cyclohexyl-2-[2-[3-(3,4-dichlorophenyl)-1,2-oxazol-5-yl]quinolin-6-yl]benzimidazole-5-carboxylic acid Chemical compound C=1C=C2N=C(C=3ON=C(C=3)C=3C=C(Cl)C(Cl)=CC=3)C=CC2=CC=1C1=NC2=CC(C(=O)O)=CC=C2N1C1CCCCC1 TXJUUJQUIXQGFK-UHFFFAOYSA-N 0.000 claims 1
VSBNMNFZYQQZFP-UHFFFAOYSA-N 1-cyclohexyl-2-[2-[3-(3-pyrrolidin-1-ylpropoxy)phenyl]quinolin-6-yl]benzimidazole-5-carboxylic acid Chemical compound C=1C=C2N=C(C=3C=C(OCCCN4CCCC4)C=CC=3)C=CC2=CC=1C1=NC2=CC(C(=O)O)=CC=C2N1C1CCCCC1 VSBNMNFZYQQZFP-UHFFFAOYSA-N 0.000 claims 1
IXOZZJADLDUXKY-UHFFFAOYSA-N 1-cyclohexyl-2-[2-[3-(pyrrolidine-1-carbonyl)phenyl]quinolin-6-yl]benzimidazole-5-carboxylic acid Chemical compound C=1C=C2N=C(C=3C=C(C=CC=3)C(=O)N3CCCC3)C=CC2=CC=1C1=NC2=CC(C(=O)O)=CC=C2N1C1CCCCC1 IXOZZJADLDUXKY-UHFFFAOYSA-N 0.000 claims 1
HNLWWNWEZNYSKF-UHFFFAOYSA-N 1-cyclohexyl-2-[2-[5-(2-methoxyethoxy)-2-phenylphenyl]quinolin-6-yl]benzimidazole-5-carboxylic acid Chemical compound C=1C=C2C=C(C=3N(C4=CC=C(C=C4N=3)C(O)=O)C3CCCCC3)C=CC2=NC=1C1=CC(OCCOC)=CC=C1C1=CC=CC=C1 HNLWWNWEZNYSKF-UHFFFAOYSA-N 0.000 claims 1
YUOTYCJWMXSSNA-UHFFFAOYSA-N 1-cyclohexyl-2-[2-[5-(methylcarbamoyl)-2-phenylphenyl]quinolin-6-yl]benzimidazole-5-carboxylic acid Chemical compound C=1C=C2C=C(C=3N(C4=CC=C(C=C4N=3)C(O)=O)C3CCCCC3)C=CC2=NC=1C1=CC(C(=O)NC)=CC=C1C1=CC=CC=C1 YUOTYCJWMXSSNA-UHFFFAOYSA-N 0.000 claims 1
JULFPUNBABNHRA-UHFFFAOYSA-N 1-cyclohexyl-2-[2-[5-[2-(dimethylamino)ethylcarbamoyl]-2-phenylphenyl]quinolin-6-yl]benzimidazole-5-carboxylic acid Chemical compound C=1C=C2C=C(C=3N(C4=CC=C(C=C4N=3)C(O)=O)C3CCCCC3)C=CC2=NC=1C1=CC(C(=O)NCCN(C)C)=CC=C1C1=CC=CC=C1 JULFPUNBABNHRA-UHFFFAOYSA-N 0.000 claims 1
GFBHJNNDCYRLJW-UHFFFAOYSA-N 1-cyclohexyl-2-[2-[5-methoxy-2-(2-methoxyphenyl)phenyl]quinolin-6-yl]benzimidazole-5-carboxylic acid Chemical compound C=1C=C2C=C(C=3N(C4=CC=C(C=C4N=3)C(O)=O)C3CCCCC3)C=CC2=NC=1C1=CC(OC)=CC=C1C1=CC=CC=C1OC GFBHJNNDCYRLJW-UHFFFAOYSA-N 0.000 claims 1
PFYGILFQDSOXQV-UHFFFAOYSA-N 1-cyclohexyl-2-[2-[5-methoxy-2-(3-methylphenyl)phenyl]quinolin-6-yl]benzimidazole-5-carboxylic acid Chemical compound C=1C=C2C=C(C=3N(C4=CC=C(C=C4N=3)C(O)=O)C3CCCCC3)C=CC2=NC=1C1=CC(OC)=CC=C1C1=CC=CC(C)=C1 PFYGILFQDSOXQV-UHFFFAOYSA-N 0.000 claims 1
JZZAYLDFVIEESA-UHFFFAOYSA-N 1-cyclohexyl-2-[2-[5-methoxy-2-(3-nitrophenyl)phenyl]quinolin-6-yl]benzimidazole-5-carboxylic acid Chemical compound C=1C=C2C=C(C=3N(C4=CC=C(C=C4N=3)C(O)=O)C3CCCCC3)C=CC2=NC=1C1=CC(OC)=CC=C1C1=CC=CC([N+]([O-])=O)=C1 JZZAYLDFVIEESA-UHFFFAOYSA-N 0.000 claims 1
CJBURBKAEMIBLM-UHFFFAOYSA-N 1-cyclohexyl-2-[2-[5-methoxy-2-(4-methoxyphenyl)phenyl]quinolin-6-yl]benzimidazole-5-carboxylic acid Chemical compound C1=CC(OC)=CC=C1C1=CC=C(OC)C=C1C1=CC=C(C=C(C=C2)C=3N(C4=CC=C(C=C4N=3)C(O)=O)C3CCCCC3)C2=N1 CJBURBKAEMIBLM-UHFFFAOYSA-N 0.000 claims 1
BJNIBDUHBVLDAH-UHFFFAOYSA-N 1-cyclohexyl-2-[2-[5-methoxy-2-(4-methylphenyl)phenyl]quinolin-6-yl]benzimidazole-5-carboxylic acid Chemical compound C=1C=C2C=C(C=3N(C4=CC=C(C=C4N=3)C(O)=O)C3CCCCC3)C=CC2=NC=1C1=CC(OC)=CC=C1C1=CC=C(C)C=C1 BJNIBDUHBVLDAH-UHFFFAOYSA-N 0.000 claims 1
ULJAZXZPPSAFJF-UHFFFAOYSA-N 1-cyclohexyl-2-[2-[5-methoxy-2-(4-nitrophenyl)phenyl]quinolin-6-yl]benzimidazole-5-carboxylic acid Chemical compound C=1C=C2C=C(C=3N(C4=CC=C(C=C4N=3)C(O)=O)C3CCCCC3)C=CC2=NC=1C1=CC(OC)=CC=C1C1=CC=C([N+]([O-])=O)C=C1 ULJAZXZPPSAFJF-UHFFFAOYSA-N 0.000 claims 1
FFPYQGJEYLUVIF-UHFFFAOYSA-N 1-cyclohexyl-2-[2-[5-methoxy-2-[4-(trifluoromethyl)phenyl]phenyl]quinolin-6-yl]benzimidazole-5-carboxylic acid Chemical compound C=1C=C2C=C(C=3N(C4=CC=C(C=C4N=3)C(O)=O)C3CCCCC3)C=CC2=NC=1C1=CC(OC)=CC=C1C1=CC=C(C(F)(F)F)C=C1 FFPYQGJEYLUVIF-UHFFFAOYSA-N 0.000 claims 1
VIOCXQKXETWUKN-UHFFFAOYSA-N 1-cyclohexyl-2-[4-(3-imidazol-1-ylpropylamino)-2-phenylquinolin-6-yl]benzimidazole-5-carboxylic acid Chemical compound C=1C=C2N=C(C=3C=CC=CC=3)C=C(NCCCN3C=NC=C3)C2=CC=1C1=NC2=CC(C(=O)O)=CC=C2N1C1CCCCC1 VIOCXQKXETWUKN-UHFFFAOYSA-N 0.000 claims 1
GANLQMYXKQUGGP-UHFFFAOYSA-N 1-cyclohexyl-2-[4-(4-hydroxybutylamino)-2-phenylquinolin-6-yl]benzimidazole-5-carboxylic acid Chemical compound C1=C2C(NCCCCO)=CC(C=3C=CC=CC=3)=NC2=CC=C1C1=NC2=CC(C(O)=O)=CC=C2N1C1CCCCC1 GANLQMYXKQUGGP-UHFFFAOYSA-N 0.000 claims 1
RWGJAVOHWBOSIC-UHFFFAOYSA-N 1-cyclohexyl-2-[4-(7-hydroxynaphthalen-2-yl)oxy-2-phenylquinolin-6-yl]benzimidazole-5-carboxylic acid Chemical compound C=1C=C2N=C(C=3C=CC=CC=3)C=C(OC=3C=C4C=C(O)C=CC4=CC=3)C2=CC=1C1=NC2=CC(C(=O)O)=CC=C2N1C1CCCCC1 RWGJAVOHWBOSIC-UHFFFAOYSA-N 0.000 claims 1
FKJHGXQDYXSQIP-UHFFFAOYSA-N 1-cyclohexyl-2-[4-(dimethylamino)-2-phenylquinolin-6-yl]benzimidazole-5-carboxylic acid Chemical compound C1=C2C(N(C)C)=CC(C=3C=CC=CC=3)=NC2=CC=C1C1=NC2=CC(C(O)=O)=CC=C2N1C1CCCCC1 FKJHGXQDYXSQIP-UHFFFAOYSA-N 0.000 claims 1
LLUBLZKOGSRRKN-UHFFFAOYSA-N 1-cyclohexyl-2-[4-[2-[(2-methylpropan-2-yl)oxycarbonylamino]ethylamino]-2-phenylquinolin-6-yl]benzimidazole-5-carboxylic acid Chemical compound C1=C2C(NCCNC(=O)OC(C)(C)C)=CC(C=3C=CC=CC=3)=NC2=CC=C1C1=NC2=CC(C(O)=O)=CC=C2N1C1CCCCC1 LLUBLZKOGSRRKN-UHFFFAOYSA-N 0.000 claims 1
HNTUQQPISDJRNG-UHFFFAOYSA-N 1-cyclohexyl-2-[7-fluoro-2-(2-phenylphenyl)quinolin-6-yl]benzimidazole-5-carboxylic acid Chemical compound C=1C2=CC=C(C=3C(=CC=CC=3)C=3C=CC=CC=3)N=C2C=C(F)C=1C1=NC2=CC(C(=O)O)=CC=C2N1C1CCCCC1 HNTUQQPISDJRNG-UHFFFAOYSA-N 0.000 claims 1
YFKCXHWQANEVLA-UHFFFAOYSA-N 1-cyclohexyl-2-[8-methyl-2-(2-phenylphenyl)quinolin-6-yl]benzimidazole-5-carboxylic acid Chemical compound N1=C2C(C)=CC(C=3N(C4=CC=C(C=C4N=3)C(O)=O)C3CCCCC3)=CC2=CC=C1C1=CC=CC=C1C1=CC=CC=C1 YFKCXHWQANEVLA-UHFFFAOYSA-N 0.000 claims 1
FPKNEGVMGLFOHY-UHFFFAOYSA-N 1-cyclohexyl-N-(5-hydroxynaphthalen-1-yl)-2-(2-phenylquinoxalin-6-yl)benzimidazole-5-carboxamide Chemical compound C1=CC=C2C(O)=CC=CC2=C1NC(=O)C(C=C1N=C2C=3C=C4N=CC(=NC4=CC=3)C=3C=CC=CC=3)=CC=C1N2C1CCCCC1 FPKNEGVMGLFOHY-UHFFFAOYSA-N 0.000 claims 1
RFCCIOKYNLDPHI-UHFFFAOYSA-N 1-cyclohexyl-N-(7-hydroxynaphthalen-1-yl)-2-(2-phenylquinoxalin-6-yl)benzimidazole-5-carboxamide Chemical compound C12=CC(O)=CC=C2C=CC=C1NC(=O)C(C=C1N=C2C=3C=C4N=CC(=NC4=CC=3)C=3C=CC=CC=3)=CC=C1N2C1CCCCC1 RFCCIOKYNLDPHI-UHFFFAOYSA-N 0.000 claims 1
RRYQKEFHHICTED-UHFFFAOYSA-N 1-cyclohexyl-n-(4-methyl-2-oxochromen-7-yl)-2-(2-phenylquinolin-6-yl)benzimidazole-5-carboxamide Chemical compound C1=CC=2C(C)=CC(=O)OC=2C=C1NC(=O)C(C=C1N=C2C=3C=C4C=CC(=NC4=CC=3)C=3C=CC=CC=3)=CC=C1N2C1CCCCC1 RRYQKEFHHICTED-UHFFFAOYSA-N 0.000 claims 1
WWCPLZVCSVPEQY-UHFFFAOYSA-N 1-cyclohexyl-n-(4-methyl-2-oxochromen-7-yl)-2-(2-phenylquinoxalin-6-yl)benzimidazole-5-carboxamide Chemical compound C1=CC=2C(C)=CC(=O)OC=2C=C1NC(=O)C(C=C1N=C2C=3C=C4N=CC(=NC4=CC=3)C=3C=CC=CC=3)=CC=C1N2C1CCCCC1 WWCPLZVCSVPEQY-UHFFFAOYSA-N 0.000 claims 1
QNQSCIQAIUMWAL-UHFFFAOYSA-N 1-cyclohexyl-n-(5-hydroxynaphthalen-1-yl)-2-(2-phenylquinolin-6-yl)benzimidazole-5-carboxamide Chemical compound C1=CC=C2C(O)=CC=CC2=C1NC(=O)C(C=C1N=C2C=3C=C4C=CC(=NC4=CC=3)C=3C=CC=CC=3)=CC=C1N2C1CCCCC1 QNQSCIQAIUMWAL-UHFFFAOYSA-N 0.000 claims 1
TVFPNKKTZWDRSG-UHFFFAOYSA-N 1-cyclohexyl-n-(7-hydroxynaphthalen-1-yl)-2-(2-phenylquinolin-6-yl)benzimidazole-5-carboxamide Chemical compound C12=CC(O)=CC=C2C=CC=C1NC(=O)C(C=C1N=C2C=3C=C4C=CC(=NC4=CC=3)C=3C=CC=CC=3)=CC=C1N2C1CCCCC1 TVFPNKKTZWDRSG-UHFFFAOYSA-N 0.000 claims 1
GALWYYIFKRCMGV-UHFFFAOYSA-N 1-cyclohexyl-n-morpholin-4-yl-2-(2-phenylquinoxalin-6-yl)benzimidazole-5-carboxamide Chemical compound C=1C=C2N(C3CCCCC3)C(C=3C=C4N=CC(=NC4=CC=3)C=3C=CC=CC=3)=NC2=CC=1C(=O)NN1CCOCC1 GALWYYIFKRCMGV-UHFFFAOYSA-N 0.000 claims 1
125000001637 1-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C(*)=C([H])C([H])=C([H])C2=C1[H] 0.000 claims 1
125000004463 2,4-dimethyl-thiazol-5-yl group Chemical group CC=1SC(=C(N1)C)* 0.000 claims 1
USHVZUVKXDVZMV-UHFFFAOYSA-N 2-(2-benzhydrylquinolin-6-yl)-1-cyclohexylbenzimidazole-5-carboxylic acid Chemical compound C=1C=C2N=C(C(C=3C=CC=CC=3)C=3C=CC=CC=3)C=CC2=CC=1C1=NC2=CC(C(=O)O)=CC=C2N1C1CCCCC1 USHVZUVKXDVZMV-UHFFFAOYSA-N 0.000 claims 1
UBFAWOXETIZXPU-UHFFFAOYSA-N 2-(4-anilino-2-phenylquinolin-6-yl)-1-cyclohexylbenzimidazole-5-carboxylic acid Chemical compound C=1C=C2N=C(C=3C=CC=CC=3)C=C(NC=3C=CC=CC=3)C2=CC=1C1=NC2=CC(C(=O)O)=CC=C2N1C1CCCCC1 UBFAWOXETIZXPU-UHFFFAOYSA-N 0.000 claims 1
LAYMXNNDBXSIKI-UHFFFAOYSA-N 2-[1-cyclohexyl-2-(2-phenylquinoxalin-6-yl)benzimidazole-5-carbonyl]-3,4-dihydro-1h-isoquinoline-3-carboxylic acid Chemical compound OC(=O)C1CC2=CC=CC=C2CN1C(=O)C(C=C1N=C2C=3C=C4N=CC(=NC4=CC=3)C=3C=CC=CC=3)=CC=C1N2C1CCCCC1 LAYMXNNDBXSIKI-UHFFFAOYSA-N 0.000 claims 1
TZMODKKQBAHXMG-UHFFFAOYSA-N 2-[1-cyclohexyl-5-(2h-tetrazol-5-yl)benzimidazol-2-yl]-6-methyl-1,5-naphthyridine Chemical compound C1=CC2=NC(C)=CC=C2N=C1C1=NC2=CC(C=3NN=NN=3)=CC=C2N1C1CCCCC1 TZMODKKQBAHXMG-UHFFFAOYSA-N 0.000 claims 1
FBSNMAKMIBPZNC-UHFFFAOYSA-N 2-[2,3-bis(3-methoxyphenyl)quinoxalin-6-yl]-1-cyclohexylbenzimidazole-5-carboxylic acid Chemical compound COC1=CC=CC(C=2C(=NC3=CC(=CC=C3N=2)C=2N(C3=CC=C(C=C3N=2)C(O)=O)C2CCCCC2)C=2C=C(OC)C=CC=2)=C1 FBSNMAKMIBPZNC-UHFFFAOYSA-N 0.000 claims 1
CVQOPXOMYOQBEZ-UHFFFAOYSA-N 2-[2,3-bis(4-bromophenyl)quinoxalin-6-yl]-1-cyclohexylbenzimidazole-5-carboxylic acid Chemical compound C=1C=C2N=C(C=3C=CC(Br)=CC=3)C(C=3C=CC(Br)=CC=3)=NC2=CC=1C1=NC2=CC(C(=O)O)=CC=C2N1C1CCCCC1 CVQOPXOMYOQBEZ-UHFFFAOYSA-N 0.000 claims 1
LUOJEGFHSPQFTL-UHFFFAOYSA-N 2-[2,3-bis(4-fluorophenyl)quinoxalin-6-yl]-1-cyclohexylbenzimidazole-5-carboxylic acid Chemical compound C=1C=C2N=C(C=3C=CC(F)=CC=3)C(C=3C=CC(F)=CC=3)=NC2=CC=1C1=NC2=CC(C(=O)O)=CC=C2N1C1CCCCC1 LUOJEGFHSPQFTL-UHFFFAOYSA-N 0.000 claims 1
QUEJZLWGIKPAEY-UHFFFAOYSA-N 2-[2,3-bis(4-methoxyphenyl)quinoxalin-6-yl]-1-cyclohexylbenzimidazole-5-carboxylic acid Chemical compound C1=CC(OC)=CC=C1C1=NC2=CC=C(C=3N(C4=CC=C(C=C4N=3)C(O)=O)C3CCCCC3)C=C2N=C1C1=CC=C(OC)C=C1 QUEJZLWGIKPAEY-UHFFFAOYSA-N 0.000 claims 1
ORUNKUHOZMXQOA-UHFFFAOYSA-N 2-[2,3-bis(4-methylphenyl)quinoxalin-6-yl]-1-cyclohexylbenzimidazole-5-carboxylic acid Chemical compound C1=CC(C)=CC=C1C1=NC2=CC=C(C=3N(C4=CC=C(C=C4N=3)C(O)=O)C3CCCCC3)C=C2N=C1C1=CC=C(C)C=C1 ORUNKUHOZMXQOA-UHFFFAOYSA-N 0.000 claims 1
YIEZQVPLDLUBSP-UHFFFAOYSA-N 2-[2,3-bis[4-(dimethylamino)phenyl]quinoxalin-6-yl]-1-cyclohexylbenzimidazole-5-carboxylic acid Chemical compound C1=CC(N(C)C)=CC=C1C1=NC2=CC=C(C=3N(C4=CC=C(C=C4N=3)C(O)=O)C3CCCCC3)C=C2N=C1C1=CC=C(N(C)C)C=C1 YIEZQVPLDLUBSP-UHFFFAOYSA-N 0.000 claims 1
VYGIKOWEPDJLBU-UHFFFAOYSA-N 2-[2-(1,3-benzodioxol-5-yl)quinolin-6-yl]-1-cyclohexylbenzimidazole-5-carboxylic acid Chemical compound C=1C=C2N=C(C=3C=C4OCOC4=CC=3)C=CC2=CC=1C1=NC2=CC(C(=O)O)=CC=C2N1C1CCCCC1 VYGIKOWEPDJLBU-UHFFFAOYSA-N 0.000 claims 1
FFQPAOCSDUTPDL-UHFFFAOYSA-N 2-[2-(1-benzofuran-2-yl)quinolin-6-yl]-1-cyclohexylbenzimidazole-5-carboxylic acid Chemical compound C=1C=C2N=C(C=3OC4=CC=CC=C4C=3)C=CC2=CC=1C1=NC2=CC(C(=O)O)=CC=C2N1C1CCCCC1 FFQPAOCSDUTPDL-UHFFFAOYSA-N 0.000 claims 1
ZVZCVQCOFYYGIW-UHFFFAOYSA-N 2-[2-(2-amino-4-methyl-1,3-thiazol-5-yl)quinolin-6-yl]-1-cyclohexylbenzimidazole-5-carboxylic acid Chemical compound N1=C(N)SC(C=2N=C3C=CC(=CC3=CC=2)C=2N(C3=CC=C(C=C3N=2)C(O)=O)C2CCCCC2)=C1C ZVZCVQCOFYYGIW-UHFFFAOYSA-N 0.000 claims 1
RTTRNHBHMSPUBM-UHFFFAOYSA-N 2-[2-(2-bromophenyl)-3-phenylquinolin-6-yl]-1-cyclohexylbenzimidazole-5-carboxylic acid Chemical compound C=1C=C2N=C(C=3C(=CC=CC=3)Br)C(C=3C=CC=CC=3)=CC2=CC=1C1=NC2=CC(C(=O)O)=CC=C2N1C1CCCCC1 RTTRNHBHMSPUBM-UHFFFAOYSA-N 0.000 claims 1
XEYQUIPUALFFPU-UHFFFAOYSA-N 2-[2-(2-bromophenyl)-4-methylquinolin-6-yl]-1-cyclohexylbenzimidazole-5-carboxylic acid Chemical compound C1=C2C(C)=CC(C=3C(=CC=CC=3)Br)=NC2=CC=C1C1=NC2=CC(C(O)=O)=CC=C2N1C1CCCCC1 XEYQUIPUALFFPU-UHFFFAOYSA-N 0.000 claims 1
RRPUCLCKNIFLMX-UHFFFAOYSA-N 2-[2-(2-bromophenyl)quinolin-6-yl]-1-cyclohexylbenzimidazole-5-carboxylic acid Chemical compound C=1C=C2N=C(C=3C(=CC=CC=3)Br)C=CC2=CC=1C1=NC2=CC(C(=O)O)=CC=C2N1C1CCCCC1 RRPUCLCKNIFLMX-UHFFFAOYSA-N 0.000 claims 1
FGCWOFPFKGXUGB-UHFFFAOYSA-N 2-[2-(3-amino-5-phenylthiophen-2-yl)quinolin-6-yl]-1-cyclohexylbenzimidazole-5-carboxylic acid Chemical compound NC=1C=C(C=2C=CC=CC=2)SC=1C(N=C1C=C2)=CC=C1C=C2C1=NC2=CC(C(O)=O)=CC=C2N1C1CCCCC1 FGCWOFPFKGXUGB-UHFFFAOYSA-N 0.000 claims 1
KELGWUIBQVUSJM-UHFFFAOYSA-N 2-[2-(3-bromophenyl)quinolin-6-yl]-1-cyclohexylbenzimidazole-5-carboxylic acid Chemical compound C=1C=C2N=C(C=3C=C(Br)C=CC=3)C=CC2=CC=1C1=NC2=CC(C(=O)O)=CC=C2N1C1CCCCC1 KELGWUIBQVUSJM-UHFFFAOYSA-N 0.000 claims 1
DFIWCCYGGYULMW-UHFFFAOYSA-N 2-[2-(4-acetamidophenyl)quinolin-6-yl]-1-cyclohexylbenzimidazole-5-carboxylic acid Chemical compound C1=CC(NC(=O)C)=CC=C1C1=CC=C(C=C(C=C2)C=3N(C4=CC=C(C=C4N=3)C(O)=O)C3CCCCC3)C2=N1 DFIWCCYGGYULMW-UHFFFAOYSA-N 0.000 claims 1
HRYWUPTTYMIPRB-UHFFFAOYSA-N 2-[2-(4-amino-3,5-dichlorophenyl)quinolin-6-yl]-1-cyclohexylbenzimidazole-5-carboxylic acid Chemical compound C1=C(Cl)C(N)=C(Cl)C=C1C1=CC=C(C=C(C=C2)C=3N(C4=CC=C(C=C4N=3)C(O)=O)C3CCCCC3)C2=N1 HRYWUPTTYMIPRB-UHFFFAOYSA-N 0.000 claims 1
FUKJFMSFTPUIIK-UHFFFAOYSA-N 2-[2-(4-amino-3-bromophenyl)quinolin-6-yl]-1-cyclohexylbenzimidazole-5-carboxylic acid Chemical compound C1=C(Br)C(N)=CC=C1C1=CC=C(C=C(C=C2)C=3N(C4=CC=C(C=C4N=3)C(O)=O)C3CCCCC3)C2=N1 FUKJFMSFTPUIIK-UHFFFAOYSA-N 0.000 claims 1
ZIPJVALXFNQYOE-UHFFFAOYSA-N 2-[2-(4-aminophenyl)quinolin-6-yl]-1-cyclohexylbenzimidazole-5-carboxylic acid Chemical compound C1=CC(N)=CC=C1C1=CC=C(C=C(C=C2)C=3N(C4=CC=C(C=C4N=3)C(O)=O)C3CCCCC3)C2=N1 ZIPJVALXFNQYOE-UHFFFAOYSA-N 0.000 claims 1
WQISVBDTCUZAMD-UHFFFAOYSA-N 2-[2-(4-chlorophenyl)-5-methoxyphenyl]-6-[1-cyclohexyl-5-(2h-tetrazol-5-yl)benzimidazol-2-yl]quinoline Chemical compound C=1C=C2C=C(C=3N(C4=CC=C(C=C4N=3)C3=NNN=N3)C3CCCCC3)C=CC2=NC=1C1=CC(OC)=CC=C1C1=CC=C(Cl)C=C1 WQISVBDTCUZAMD-UHFFFAOYSA-N 0.000 claims 1
QJPIXLWGFCYGRD-UHFFFAOYSA-N 2-[2-(6-chloro-9-methylcarbazol-3-yl)quinolin-6-yl]-1-cyclohexylbenzimidazole-5-carboxylic acid Chemical compound C=1C=C2N(C)C3=CC=C(Cl)C=C3C2=CC=1C(N=C1C=C2)=CC=C1C=C2C1=NC2=CC(C(O)=O)=CC=C2N1C1CCCCC1 QJPIXLWGFCYGRD-UHFFFAOYSA-N 0.000 claims 1
XVDJFFGTUGGVJK-UHFFFAOYSA-N 2-[2-(7-bromo-5-methoxy-1-benzofuran-2-yl)quinolin-6-yl]-1-cyclohexylbenzimidazole-5-carboxylic acid Chemical compound C=1C2=CC(OC)=CC(Br)=C2OC=1C(N=C1C=C2)=CC=C1C=C2C1=NC2=CC(C(O)=O)=CC=C2N1C1CCCCC1 XVDJFFGTUGGVJK-UHFFFAOYSA-N 0.000 claims 1
MHAVNMBXIJKFFM-UHFFFAOYSA-N 2-[2-[(1-amino-1-oxo-3-phenylpropan-2-yl)carbamoyl]quinolin-6-yl]-1-cyclohexylbenzimidazole-5-carboxylic acid Chemical compound C=1C=C2C=C(C=3N(C4=CC=C(C=C4N=3)C(O)=O)C3CCCCC3)C=CC2=NC=1C(=O)NC(C(=O)N)CC1=CC=CC=C1 MHAVNMBXIJKFFM-UHFFFAOYSA-N 0.000 claims 1
OGEQXQUKLGUYIQ-UHFFFAOYSA-N 2-[2-[(1-amino-1-oxopropan-2-yl)carbamoyl]quinolin-6-yl]-1-cyclohexylbenzimidazole-5-carboxylic acid Chemical compound C1=CC2=NC(C(=O)NC(C)C(N)=O)=CC=C2C=C1C1=NC2=CC(C(O)=O)=CC=C2N1C1CCCCC1 OGEQXQUKLGUYIQ-UHFFFAOYSA-N 0.000 claims 1
BZAIOOFOJHNMDZ-UHFFFAOYSA-N 2-[2-[(1-amino-3-hydroxy-1-oxopropan-2-yl)carbamoyl]quinolin-6-yl]-1-cyclohexylbenzimidazole-5-carboxylic acid Chemical compound C1=CC2=NC(C(=O)NC(CO)C(=O)N)=CC=C2C=C1C1=NC2=CC(C(O)=O)=CC=C2N1C1CCCCC1 BZAIOOFOJHNMDZ-UHFFFAOYSA-N 0.000 claims 1
WETDHZDZKCCQAU-UHFFFAOYSA-N 2-[2-[(4-chlorophenyl)-cyclohexylcarbamoyl]quinolin-6-yl]-1-cyclohexylbenzimidazole-5-carboxylic acid Chemical compound C=1C=C2N=C(C(=O)N(C3CCCCC3)C=3C=CC(Cl)=CC=3)C=CC2=CC=1C1=NC2=CC(C(=O)O)=CC=C2N1C1CCCCC1 WETDHZDZKCCQAU-UHFFFAOYSA-N 0.000 claims 1
WEGXBUJYLWRHOY-UHFFFAOYSA-N 2-[2-[(4-chlorophenyl)-propan-2-ylcarbamoyl]quinolin-6-yl]-1-cyclohexylbenzimidazole-5-carboxylic acid Chemical compound C=1C=C(Cl)C=CC=1N(C(C)C)C(=O)C(N=C1C=C2)=CC=C1C=C2C1=NC2=CC(C(O)=O)=CC=C2N1C1CCCCC1 WEGXBUJYLWRHOY-UHFFFAOYSA-N 0.000 claims 1
UXBKIKNKACHJFS-UHFFFAOYSA-N 2-[2-[(4-chlorophenyl)carbamoyl]quinolin-6-yl]-1-cyclohexylbenzimidazole-5-carboxylic acid Chemical compound C=1C=C2N=C(C(=O)NC=3C=CC(Cl)=CC=3)C=CC2=CC=1C1=NC2=CC(C(=O)O)=CC=C2N1C1CCCCC1 UXBKIKNKACHJFS-UHFFFAOYSA-N 0.000 claims 1
MILYPMGYCVEJJG-UHFFFAOYSA-N 2-[2-[(4-chlorophenyl)methylcarbamoyl]quinolin-6-yl]-1-cyclohexylbenzimidazole-5-carboxylic acid Chemical compound C=1C=C2N=C(C(=O)NCC=3C=CC(Cl)=CC=3)C=CC2=CC=1C1=NC2=CC(C(=O)O)=CC=C2N1C1CCCCC1 MILYPMGYCVEJJG-UHFFFAOYSA-N 0.000 claims 1
NGQUQLTYDCQAQZ-UHFFFAOYSA-N 2-[2-[1-(2-chloropyridin-3-yl)-2,4-dioxopyrimidin-5-yl]quinolin-6-yl]-1-cyclohexylbenzimidazole-5-carboxylic acid Chemical compound C=1C=C2N=C(C=3C(NC(=O)N(C=4C(=NC=CC=4)Cl)C=3)=O)C=CC2=CC=1C1=NC2=CC(C(=O)O)=CC=C2N1C1CCCCC1 NGQUQLTYDCQAQZ-UHFFFAOYSA-N 0.000 claims 1
WQJLBMCSBSAISQ-UHFFFAOYSA-N 2-[2-[2-(3-carboxyphenyl)-5-methoxyphenyl]quinolin-6-yl]-1-cyclohexylbenzimidazole-5-carboxylic acid Chemical compound C=1C=C2C=C(C=3N(C4=CC=C(C=C4N=3)C(O)=O)C3CCCCC3)C=CC2=NC=1C1=CC(OC)=CC=C1C1=CC=CC(C(O)=O)=C1 WQJLBMCSBSAISQ-UHFFFAOYSA-N 0.000 claims 1
SLPLUXZWSIHECQ-UHFFFAOYSA-N 2-[2-[2-(3-chloro-4-fluorophenyl)-5-methoxyphenyl]quinolin-6-yl]-1-cyclohexylbenzimidazole-5-carboxylic acid Chemical compound C=1C=C2C=C(C=3N(C4=CC=C(C=C4N=3)C(O)=O)C3CCCCC3)C=CC2=NC=1C1=CC(OC)=CC=C1C1=CC=C(F)C(Cl)=C1 SLPLUXZWSIHECQ-UHFFFAOYSA-N 0.000 claims 1
BMFCECSHRFZFNW-UHFFFAOYSA-N 2-[2-[2-(3-chlorophenyl)-5-methoxyphenyl]quinolin-6-yl]-1-cyclohexylbenzimidazole-5-carboxylic acid Chemical compound C=1C=C2C=C(C=3N(C4=CC=C(C=C4N=3)C(O)=O)C3CCCCC3)C=CC2=NC=1C1=CC(OC)=CC=C1C1=CC=CC(Cl)=C1 BMFCECSHRFZFNW-UHFFFAOYSA-N 0.000 claims 1
FKDZBUKPQXAEKP-UHFFFAOYSA-N 2-[2-[2-(4-carbamoylphenyl)-5-methoxyphenyl]quinolin-6-yl]-1-cyclohexylbenzimidazole-5-carboxylic acid Chemical compound C=1C=C2C=C(C=3N(C4=CC=C(C=C4N=3)C(O)=O)C3CCCCC3)C=CC2=NC=1C1=CC(OC)=CC=C1C1=CC=C(C(N)=O)C=C1 FKDZBUKPQXAEKP-UHFFFAOYSA-N 0.000 claims 1
JIHCVCQVACOOIY-UHFFFAOYSA-N 2-[2-[2-(4-carboxyphenyl)-5-(pyrrolidine-1-carbonyl)phenyl]quinolin-6-yl]-1-cyclohexylbenzimidazole-5-carboxylic acid Chemical compound C1=CC(C(=O)O)=CC=C1C1=CC=C(C(=O)N2CCCC2)C=C1C1=CC=C(C=C(C=C2)C=3N(C4=CC=C(C=C4N=3)C(O)=O)C3CCCCC3)C2=N1 JIHCVCQVACOOIY-UHFFFAOYSA-N 0.000 claims 1
HSMUPVZRSDFSTA-UHFFFAOYSA-N 2-[2-[2-(4-carboxyphenyl)-5-methoxyphenyl]quinolin-6-yl]-1-cyclohexylbenzimidazole-5-carboxylic acid Chemical compound C=1C=C2C=C(C=3N(C4=CC=C(C=C4N=3)C(O)=O)C3CCCCC3)C=CC2=NC=1C1=CC(OC)=CC=C1C1=CC=C(C(O)=O)C=C1 HSMUPVZRSDFSTA-UHFFFAOYSA-N 0.000 claims 1
YQYDQOKXAJZAAQ-UHFFFAOYSA-N 2-[2-[2-(4-chlorophenyl)-4-methyl-1,3-thiazol-5-yl]quinolin-6-yl]-1-cyclohexylbenzimidazole-5-carboxylic acid Chemical compound CC=1N=C(C=2C=CC(Cl)=CC=2)SC=1C(N=C1C=C2)=CC=C1C=C2C1=NC2=CC(C(O)=O)=CC=C2N1C1CCCCC1 YQYDQOKXAJZAAQ-UHFFFAOYSA-N 0.000 claims 1
TYUBKUPQRBSBFI-UHFFFAOYSA-N 2-[2-[2-(4-chlorophenyl)-5-(2-ethoxyethoxy)phenyl]quinolin-6-yl]-1-cyclohexylbenzimidazole-5-carboxylic acid Chemical compound C=1C=C2C=C(C=3N(C4=CC=C(C=C4N=3)C(O)=O)C3CCCCC3)C=CC2=NC=1C1=CC(OCCOCC)=CC=C1C1=CC=C(Cl)C=C1 TYUBKUPQRBSBFI-UHFFFAOYSA-N 0.000 claims 1
ZBEARXWXYRRERC-UHFFFAOYSA-N 2-[2-[2-(4-chlorophenyl)-5-(2-methoxyethoxy)phenyl]quinolin-6-yl]-1-cyclohexylbenzimidazole-5-carboxylic acid Chemical compound C=1C=C2C=C(C=3N(C4=CC=C(C=C4N=3)C(O)=O)C3CCCCC3)C=CC2=NC=1C1=CC(OCCOC)=CC=C1C1=CC=C(Cl)C=C1 ZBEARXWXYRRERC-UHFFFAOYSA-N 0.000 claims 1
VGAOKTIREZPOIH-UHFFFAOYSA-N 2-[2-[2-(4-chlorophenyl)-5-(2-oxo-2-pyrrolidin-1-ylethoxy)phenyl]quinolin-6-yl]-1-cyclohexylbenzimidazole-5-carboxylic acid Chemical compound C=1C=C2N=C(C=3C(=CC=C(OCC(=O)N4CCCC4)C=3)C=3C=CC(Cl)=CC=3)C=CC2=CC=1C1=NC2=CC(C(=O)O)=CC=C2N1C1CCCCC1 VGAOKTIREZPOIH-UHFFFAOYSA-N 0.000 claims 1
BBJFPPYXWHVRNS-UHFFFAOYSA-N 2-[2-[2-(4-chlorophenyl)-5-(3-pyrrolidin-1-ylpropoxy)phenyl]quinolin-6-yl]-1-cyclohexylbenzimidazole-5-carboxylic acid Chemical compound C=1C=C2N=C(C=3C(=CC=C(OCCCN4CCCC4)C=3)C=3C=CC(Cl)=CC=3)C=CC2=CC=1C1=NC2=CC(C(=O)O)=CC=C2N1C1CCCCC1 BBJFPPYXWHVRNS-UHFFFAOYSA-N 0.000 claims 1
STOHBULMKCKTMF-UHFFFAOYSA-N 2-[2-[2-(4-chlorophenyl)-5-(methylcarbamoyl)phenyl]quinolin-6-yl]-1-cyclohexylbenzimidazole-5-carboxylic acid Chemical compound C=1C=C2C=C(C=3N(C4=CC=C(C=C4N=3)C(O)=O)C3CCCCC3)C=CC2=NC=1C1=CC(C(=O)NC)=CC=C1C1=CC=C(Cl)C=C1 STOHBULMKCKTMF-UHFFFAOYSA-N 0.000 claims 1
KPWIRNCVOZVPSL-UHFFFAOYSA-N 2-[2-[2-(4-chlorophenyl)-5-(pyrrolidine-1-carbonyl)phenyl]quinolin-6-yl]-1-cyclohexylbenzimidazole-5-carboxylic acid Chemical compound C=1C=C2N=C(C=3C(=CC=C(C=3)C(=O)N3CCCC3)C=3C=CC(Cl)=CC=3)C=CC2=CC=1C1=NC2=CC(C(=O)O)=CC=C2N1C1CCCCC1 KPWIRNCVOZVPSL-UHFFFAOYSA-N 0.000 claims 1
SHUJCQNXBFTUEJ-UHFFFAOYSA-N 2-[2-[2-(4-chlorophenyl)-5-(pyrrolidine-1-carbonyl)phenyl]quinolin-6-yl]-3-cyclohexylimidazo[4,5-b]pyridine-6-carboxylic acid Chemical compound C=1C=C2N=C(C=3C(=CC=C(C=3)C(=O)N3CCCC3)C=3C=CC(Cl)=CC=3)C=CC2=CC=1C1=NC2=CC(C(=O)O)=CN=C2N1C1CCCCC1 SHUJCQNXBFTUEJ-UHFFFAOYSA-N 0.000 claims 1
NOHJMSAMTLUEFB-UHFFFAOYSA-N 2-[2-[2-(4-chlorophenyl)-5-[2-(dimethylamino)ethylcarbamoyl]phenyl]quinolin-6-yl]-1-cyclohexylbenzimidazole-5-carboxylic acid Chemical compound C=1C=C2C=C(C=3N(C4=CC=C(C=C4N=3)C(O)=O)C3CCCCC3)C=CC2=NC=1C1=CC(C(=O)NCCN(C)C)=CC=C1C1=CC=C(Cl)C=C1 NOHJMSAMTLUEFB-UHFFFAOYSA-N 0.000 claims 1
WSCMEGFDKQPUMO-UHFFFAOYSA-N 2-[2-[2-(4-chlorophenyl)-5-fluorophenyl]quinolin-6-yl]-1-cyclohexylbenzimidazole-5-carboxylic acid Chemical compound C=1C=C2N=C(C=3C(=CC=C(F)C=3)C=3C=CC(Cl)=CC=3)C=CC2=CC=1C1=NC2=CC(C(=O)O)=CC=C2N1C1CCCCC1 WSCMEGFDKQPUMO-UHFFFAOYSA-N 0.000 claims 1
AZWSYBCULBQENB-UHFFFAOYSA-N 2-[2-[2-(4-chlorophenyl)-5-hydroxyphenyl]quinolin-6-yl]-1-cyclohexylbenzimidazole-5-carboxylic acid Chemical compound C=1C=C2N=C(C=3C(=CC=C(O)C=3)C=3C=CC(Cl)=CC=3)C=CC2=CC=1C1=NC2=CC(C(=O)O)=CC=C2N1C1CCCCC1 AZWSYBCULBQENB-UHFFFAOYSA-N 0.000 claims 1
LKFAKEPUDXBMIU-UHFFFAOYSA-N 2-[2-[2-(4-chlorophenyl)-5-hydroxyphenyl]quinolin-6-yl]-3-cyclohexylimidazo[4,5-b]pyridine-6-carboxylic acid Chemical compound C=1C=C2N=C(C=3C(=CC=C(O)C=3)C=3C=CC(Cl)=CC=3)C=CC2=CC=1C1=NC2=CC(C(=O)O)=CN=C2N1C1CCCCC1 LKFAKEPUDXBMIU-UHFFFAOYSA-N 0.000 claims 1
QPSPQYUQNFBKGT-UHFFFAOYSA-N 2-[2-[2-(4-chlorophenyl)-5-methoxyphenyl]quinolin-6-yl]-1-(2-methylcyclohexyl)benzimidazole-5-carboxylic acid Chemical compound C=1C=C2C=C(C=3N(C4=CC=C(C=C4N=3)C(O)=O)C3C(CCCC3)C)C=CC2=NC=1C1=CC(OC)=CC=C1C1=CC=C(Cl)C=C1 QPSPQYUQNFBKGT-UHFFFAOYSA-N 0.000 claims 1
GXPRWFPSCBXVNX-UHFFFAOYSA-N 2-[2-[2-(4-chlorophenyl)-5-methoxyphenyl]quinolin-6-yl]-1-(2-methylpropyl)benzimidazole-5-carboxylic acid Chemical compound C=1C=C2C=C(C=3N(C4=CC=C(C=C4N=3)C(O)=O)CC(C)C)C=CC2=NC=1C1=CC(OC)=CC=C1C1=CC=C(Cl)C=C1 GXPRWFPSCBXVNX-UHFFFAOYSA-N 0.000 claims 1
FBKWZHOKMJSLMI-UHFFFAOYSA-N 2-[2-[2-(4-chlorophenyl)-5-methoxyphenyl]quinolin-6-yl]-1-(3,3,5-trimethylcyclohexyl)benzimidazole-5-carboxylic acid Chemical compound C=1C=C2C=C(C=3N(C4=CC=C(C=C4N=3)C(O)=O)C3CC(C)(C)CC(C)C3)C=CC2=NC=1C1=CC(OC)=CC=C1C1=CC=C(Cl)C=C1 FBKWZHOKMJSLMI-UHFFFAOYSA-N 0.000 claims 1
GBKXBGUYCNWMRZ-UHFFFAOYSA-N 2-[2-[2-(4-chlorophenyl)-5-methoxyphenyl]quinolin-6-yl]-1-(3-methylbutyl)benzimidazole-5-carboxylic acid Chemical compound C=1C=C2C=C(C=3N(C4=CC=C(C=C4N=3)C(O)=O)CCC(C)C)C=CC2=NC=1C1=CC(OC)=CC=C1C1=CC=C(Cl)C=C1 GBKXBGUYCNWMRZ-UHFFFAOYSA-N 0.000 claims 1
SXWCOLAFFXAHCQ-UHFFFAOYSA-N 2-[2-[2-(4-chlorophenyl)-5-methoxyphenyl]quinolin-6-yl]-1-(cyclopropylmethyl)benzimidazole-5-carboxylic acid Chemical compound C=1C=C2C=C(C=3N(C4=CC=C(C=C4N=3)C(O)=O)CC3CC3)C=CC2=NC=1C1=CC(OC)=CC=C1C1=CC=C(Cl)C=C1 SXWCOLAFFXAHCQ-UHFFFAOYSA-N 0.000 claims 1
ZDOXUUMHTBISLC-UHFFFAOYSA-N 2-[2-[2-(4-chlorophenyl)-5-methoxyphenyl]quinolin-6-yl]-1-(oxolan-2-ylmethyl)benzimidazole-5-carboxylic acid Chemical compound C=1C=C2C=C(C=3N(C4=CC=C(C=C4N=3)C(O)=O)CC3OCCC3)C=CC2=NC=1C1=CC(OC)=CC=C1C1=CC=C(Cl)C=C1 ZDOXUUMHTBISLC-UHFFFAOYSA-N 0.000 claims 1
LAXVTWNFTHUEHW-UHFFFAOYSA-N 2-[2-[2-(4-chlorophenyl)-5-methoxyphenyl]quinolin-6-yl]-1-[2-(dimethylamino)ethyl]benzimidazole-5-carboxylic acid Chemical compound C=1C=C2C=C(C=3N(C4=CC=C(C=C4N=3)C(O)=O)CCN(C)C)C=CC2=NC=1C1=CC(OC)=CC=C1C1=CC=C(Cl)C=C1 LAXVTWNFTHUEHW-UHFFFAOYSA-N 0.000 claims 1
YPCADOMCZAEAFU-UHFFFAOYSA-N 2-[2-[2-(4-chlorophenyl)-5-methoxyphenyl]quinolin-6-yl]-1-cyclohexylbenzimidazole-5-carboxylic acid Chemical compound C=1C=C2C=C(C=3N(C4=CC=C(C=C4N=3)C(O)=O)C3CCCCC3)C=CC2=NC=1C1=CC(OC)=CC=C1C1=CC=C(Cl)C=C1 YPCADOMCZAEAFU-UHFFFAOYSA-N 0.000 claims 1
DEDVMQFGUFKREG-UHFFFAOYSA-N 2-[2-[2-(4-chlorophenyl)-5-methoxyphenyl]quinolin-6-yl]-1-cyclopentylbenzimidazole-5-carboxylic acid Chemical compound C=1C=C2C=C(C=3N(C4=CC=C(C=C4N=3)C(O)=O)C3CCCC3)C=CC2=NC=1C1=CC(OC)=CC=C1C1=CC=C(Cl)C=C1 DEDVMQFGUFKREG-UHFFFAOYSA-N 0.000 claims 1
OQBZZXCNXRQACC-UHFFFAOYSA-N 2-[2-[2-(4-chlorophenyl)-5-methoxyphenyl]quinolin-6-yl]-1-cyclopropylbenzimidazole-5-carboxylic acid Chemical compound C=1C=C2C=C(C=3N(C4=CC=C(C=C4N=3)C(O)=O)C3CC3)C=CC2=NC=1C1=CC(OC)=CC=C1C1=CC=C(Cl)C=C1 OQBZZXCNXRQACC-UHFFFAOYSA-N 0.000 claims 1
LKERBKSXLOUDRN-UHFFFAOYSA-N 2-[2-[2-(4-chlorophenyl)-5-methoxyphenyl]quinolin-6-yl]-1-ethylbenzimidazole-5-carboxylic acid Chemical compound N=1C2=CC(C(O)=O)=CC=C2N(CC)C=1C(C=C1C=C2)=CC=C1N=C2C1=CC(OC)=CC=C1C1=CC=C(Cl)C=C1 LKERBKSXLOUDRN-UHFFFAOYSA-N 0.000 claims 1
BTNASADGMQFNKE-UHFFFAOYSA-N 2-[2-[2-(4-chlorophenyl)-5-methoxyphenyl]quinolin-6-yl]-1-pentan-3-ylbenzimidazole-5-carboxylic acid Chemical compound N=1C2=CC(C(O)=O)=CC=C2N(C(CC)CC)C=1C(C=C1C=C2)=CC=C1N=C2C1=CC(OC)=CC=C1C1=CC=C(Cl)C=C1 BTNASADGMQFNKE-UHFFFAOYSA-N 0.000 claims 1
XCROQJSYNOXHNL-UHFFFAOYSA-N 2-[2-[2-(4-chlorophenyl)-5-methoxyphenyl]quinolin-6-yl]-1-piperidin-4-ylbenzimidazole-5-carboxylic acid Chemical compound C=1C=C2C=C(C=3N(C4=CC=C(C=C4N=3)C(O)=O)C3CCNCC3)C=CC2=NC=1C1=CC(OC)=CC=C1C1=CC=C(Cl)C=C1 XCROQJSYNOXHNL-UHFFFAOYSA-N 0.000 claims 1
WXWRIUDDCACZLA-UHFFFAOYSA-N 2-[2-[2-(4-chlorophenyl)-5-methoxyphenyl]quinolin-6-yl]-1-propan-2-ylbenzimidazole-5-carboxylic acid Chemical compound C=1C=C2C=C(C=3N(C4=CC=C(C=C4N=3)C(O)=O)C(C)C)C=CC2=NC=1C1=CC(OC)=CC=C1C1=CC=C(Cl)C=C1 WXWRIUDDCACZLA-UHFFFAOYSA-N 0.000 claims 1
BNVDYQCKPCCNEK-UHFFFAOYSA-N 2-[2-[2-(4-chlorophenyl)-5-methoxyphenyl]quinolin-6-yl]-3-cyclohexyl-1h-indole-6-carboxylic acid Chemical compound C=1C=C2C=C(C3=C(C4=CC=C(C=C4N3)C(O)=O)C3CCCCC3)C=CC2=NC=1C1=CC(OC)=CC=C1C1=CC=C(Cl)C=C1 BNVDYQCKPCCNEK-UHFFFAOYSA-N 0.000 claims 1
LPVSKTVCXGNFAR-UHFFFAOYSA-N 2-[2-[2-(4-chlorophenyl)-5-methoxyphenyl]quinolin-6-yl]-3-cyclohexylbenzimidazole-4-carboxylic acid Chemical compound C=1C=C2C=C(C=3N(C4=C(C(O)=O)C=CC=C4N=3)C3CCCCC3)C=CC2=NC=1C1=CC(OC)=CC=C1C1=CC=C(Cl)C=C1 LPVSKTVCXGNFAR-UHFFFAOYSA-N 0.000 claims 1
VRFGOABDSCUVJO-UHFFFAOYSA-N 2-[2-[2-(4-chlorophenyl)-5-methoxyphenyl]quinolin-6-yl]-3-cyclohexylbenzimidazole-5-carboxylic acid Chemical compound C=1C=C2C=C(C=3N(C4=CC(=CC=C4N=3)C(O)=O)C3CCCCC3)C=CC2=NC=1C1=CC(OC)=CC=C1C1=CC=C(Cl)C=C1 VRFGOABDSCUVJO-UHFFFAOYSA-N 0.000 claims 1
CEKOBFOATFYLIE-UHFFFAOYSA-N 2-[2-[2-(4-chlorophenyl)-5-methoxyphenyl]quinolin-6-yl]-3-cyclohexylimidazo[4,5-b]pyridine-6-carboxylic acid Chemical compound C=1C=C2C=C(C=3N(C4=NC=C(C=C4N=3)C(O)=O)C3CCCCC3)C=CC2=NC=1C1=CC(OC)=CC=C1C1=CC=C(Cl)C=C1 CEKOBFOATFYLIE-UHFFFAOYSA-N 0.000 claims 1
VLHAEAMPFYTUSN-UHFFFAOYSA-N 2-[2-[2-(4-chlorophenyl)-5-nitrophenyl]quinolin-6-yl]-1-cyclohexylbenzimidazole-5-carboxylic acid Chemical compound C=1C=C2N=C(C=3C(=CC=C(C=3)[N+]([O-])=O)C=3C=CC(Cl)=CC=3)C=CC2=CC=1C1=NC2=CC(C(=O)O)=CC=C2N1C1CCCCC1 VLHAEAMPFYTUSN-UHFFFAOYSA-N 0.000 claims 1
NUHMWLYBAUUEHY-UHFFFAOYSA-N 2-[2-[2-(4-chlorophenyl)phenyl]-3-phenylquinolin-6-yl]-1-cyclohexylbenzimidazole-5-carboxylic acid Chemical compound C=1C=C2N=C(C=3C(=CC=CC=3)C=3C=CC(Cl)=CC=3)C(C=3C=CC=CC=3)=CC2=CC=1C1=NC2=CC(C(=O)O)=CC=C2N1C1CCCCC1 NUHMWLYBAUUEHY-UHFFFAOYSA-N 0.000 claims 1
FLZCHEZCWYIMSC-UHFFFAOYSA-N 2-[2-[2-(4-chlorophenyl)phenyl]-4-methylquinolin-6-yl]-1-cyclohexylbenzimidazole-5-carboxylic acid Chemical compound C1=C2C(C)=CC(C=3C(=CC=CC=3)C=3C=CC(Cl)=CC=3)=NC2=CC=C1C1=NC2=CC(C(O)=O)=CC=C2N1C1CCCCC1 FLZCHEZCWYIMSC-UHFFFAOYSA-N 0.000 claims 1
QYQZSEGNBIIXGY-UHFFFAOYSA-N 2-[2-[2-(4-chlorophenyl)phenyl]-7-fluoroquinolin-6-yl]-1-cyclohexylbenzimidazole-5-carboxylic acid Chemical compound C=1C2=CC=C(C=3C(=CC=CC=3)C=3C=CC(Cl)=CC=3)N=C2C=C(F)C=1C1=NC2=CC(C(=O)O)=CC=C2N1C1CCCCC1 QYQZSEGNBIIXGY-UHFFFAOYSA-N 0.000 claims 1
SESWBGUXTZSOTE-UHFFFAOYSA-N 2-[2-[2-(4-chlorophenyl)phenyl]-8-methylquinolin-6-yl]-1-cyclohexylbenzimidazole-5-carboxylic acid Chemical compound N1=C2C(C)=CC(C=3N(C4=CC=C(C=C4N=3)C(O)=O)C3CCCCC3)=CC2=CC=C1C1=CC=CC=C1C1=CC=C(Cl)C=C1 SESWBGUXTZSOTE-UHFFFAOYSA-N 0.000 claims 1
VDCZNJIJCAYCFH-UHFFFAOYSA-N 2-[2-[2-(4-chlorophenyl)phenyl]quinolin-6-yl]-1-cyclohexylbenzimidazole-5-carboxylic acid Chemical compound C=1C=C2N=C(C=3C(=CC=CC=3)C=3C=CC(Cl)=CC=3)C=CC2=CC=1C1=NC2=CC(C(=O)O)=CC=C2N1C1CCCCC1 VDCZNJIJCAYCFH-UHFFFAOYSA-N 0.000 claims 1
OLTKFIOQURBTQV-UHFFFAOYSA-N 2-[2-[2-(4-chlorophenyl)phenyl]quinolin-6-yl]-3-cyclohexylimidazo[4,5-b]pyridine-6-carboxylic acid Chemical compound C=1C=C2N=C(C=3C(=CC=CC=3)C=3C=CC(Cl)=CC=3)C=CC2=CC=1C1=NC2=CC(C(=O)O)=CN=C2N1C1CCCCC1 OLTKFIOQURBTQV-UHFFFAOYSA-N 0.000 claims 1
SJDOXUXYQUMQOG-UHFFFAOYSA-N 2-[2-[2-(4-chlorophenyl)phenyl]quinolin-6-yl]-3h-benzimidazole-5-carboxylic acid Chemical compound N1C2=CC(C(=O)O)=CC=C2N=C1C(C=C1C=C2)=CC=C1N=C2C1=CC=CC=C1C1=CC=C(Cl)C=C1 SJDOXUXYQUMQOG-UHFFFAOYSA-N 0.000 claims 1
BLAFWSFUHKQNIX-UHFFFAOYSA-N 2-[2-[2-(4-cyanophenyl)-5-methoxyphenyl]quinolin-6-yl]-1-cyclohexylbenzimidazole-5-carboxylic acid Chemical compound C=1C=C2C=C(C=3N(C4=CC=C(C=C4N=3)C(O)=O)C3CCCCC3)C=CC2=NC=1C1=CC(OC)=CC=C1C1=CC=C(C#N)C=C1 BLAFWSFUHKQNIX-UHFFFAOYSA-N 0.000 claims 1
NBEXYWGIMFLACL-UHFFFAOYSA-N 2-[2-[2-[4-(aminomethyl)phenyl]-5-methoxyphenyl]quinolin-6-yl]-1-cyclohexylbenzimidazole-5-carboxylic acid Chemical compound C=1C=C2C=C(C=3N(C4=CC=C(C=C4N=3)C(O)=O)C3CCCCC3)C=CC2=NC=1C1=CC(OC)=CC=C1C1=CC=C(CN)C=C1 NBEXYWGIMFLACL-UHFFFAOYSA-N 0.000 claims 1
OJHJAXYNKBFYTA-UHFFFAOYSA-N 2-[2-[2-chloro-4-(4-chlorophenoxy)phenyl]quinolin-6-yl]-1-cyclohexylbenzimidazole-5-carboxylic acid Chemical compound C=1C=C2N=C(C=3C(=CC(OC=4C=CC(Cl)=CC=4)=CC=3)Cl)C=CC2=CC=1C1=NC2=CC(C(=O)O)=CC=C2N1C1CCCCC1 OJHJAXYNKBFYTA-UHFFFAOYSA-N 0.000 claims 1
BZKCZUAHPXDMAR-UHFFFAOYSA-N 2-[2-[3-(4-chlorophenyl)-5-methyl-1,2-oxazol-4-yl]quinolin-6-yl]-1-cyclohexylbenzimidazole-5-carboxylic acid Chemical compound CC=1ON=C(C=2C=CC(Cl)=CC=2)C=1C(N=C1C=C2)=CC=C1C=C2C1=NC2=CC(C(O)=O)=CC=C2N1C1CCCCC1 BZKCZUAHPXDMAR-UHFFFAOYSA-N 0.000 claims 1
BAFOCWWGOHDNNM-UHFFFAOYSA-N 2-[2-[3-(4-chlorophenyl)phenyl]quinolin-6-yl]-1-cyclohexylbenzimidazole-5-carboxylic acid Chemical compound C=1C=C2N=C(C=3C=C(C=CC=3)C=3C=CC(Cl)=CC=3)C=CC2=CC=1C1=NC2=CC(C(=O)O)=CC=C2N1C1CCCCC1 BAFOCWWGOHDNNM-UHFFFAOYSA-N 0.000 claims 1
ILUSCGQUWDKMNO-UHFFFAOYSA-N 2-[2-[3-(carboxymethoxy)phenyl]quinolin-6-yl]-1-cyclohexylbenzimidazole-5-carboxylic acid Chemical compound OC(=O)COC1=CC=CC(C=2N=C3C=CC(=CC3=CC=2)C=2N(C3=CC=C(C=C3N=2)C(O)=O)C2CCCCC2)=C1 ILUSCGQUWDKMNO-UHFFFAOYSA-N 0.000 claims 1
MMANKFKBTGWHHJ-UHFFFAOYSA-N 2-[2-[3-(carboxymethyl)-2,2-dimethylcyclobutyl]quinolin-6-yl]-1-cyclohexylbenzimidazole-5-carboxylic acid Chemical compound CC1(C)C(CC(O)=O)CC1C1=CC=C(C=C(C=C2)C=3N(C4=CC=C(C=C4N=3)C(O)=O)C3CCCCC3)C2=N1 MMANKFKBTGWHHJ-UHFFFAOYSA-N 0.000 claims 1
OPNWPXBDVWIBHD-UHFFFAOYSA-N 2-[2-[5-(4-chlorophenyl)-2-methylfuran-3-yl]quinolin-6-yl]-1-cyclohexylbenzimidazole-5-carboxylic acid Chemical compound CC=1OC(C=2C=CC(Cl)=CC=2)=CC=1C(N=C1C=C2)=CC=C1C=C2C1=NC2=CC(C(O)=O)=CC=C2N1C1CCCCC1 OPNWPXBDVWIBHD-UHFFFAOYSA-N 0.000 claims 1
RTUGKMQUDIXATR-UHFFFAOYSA-N 2-[2-[5-(carboxymethoxy)-2-(4-chlorophenyl)phenyl]quinolin-6-yl]-1-cyclohexylbenzimidazole-5-carboxylic acid Chemical compound C=1C=C2C=C(C=3N(C4=CC=C(C=C4N=3)C(O)=O)C3CCCCC3)C=CC2=NC=1C1=CC(OCC(=O)O)=CC=C1C1=CC=C(Cl)C=C1 RTUGKMQUDIXATR-UHFFFAOYSA-N 0.000 claims 1
XUGXULJBXMHGNN-UHFFFAOYSA-N 2-[2-[5-(carboxymethoxy)-2-phenylphenyl]quinolin-6-yl]-1-cyclohexylbenzimidazole-5-carboxylic acid Chemical compound C=1C=C2C=C(C=3N(C4=CC=C(C=C4N=3)C(O)=O)C3CCCCC3)C=CC2=NC=1C1=CC(OCC(=O)O)=CC=C1C1=CC=CC=C1 XUGXULJBXMHGNN-UHFFFAOYSA-N 0.000 claims 1
ZEHLOKMVPIDBDF-UHFFFAOYSA-N 2-[2-[5-[(2-amino-2-oxoethyl)carbamoyl]-2-(4-chlorophenyl)phenyl]quinolin-6-yl]-1-cyclohexylbenzimidazole-5-carboxylic acid Chemical compound C=1C=C2C=C(C=3N(C4=CC=C(C=C4N=3)C(O)=O)C3CCCCC3)C=CC2=NC=1C1=CC(C(=O)NCC(=O)N)=CC=C1C1=CC=C(Cl)C=C1 ZEHLOKMVPIDBDF-UHFFFAOYSA-N 0.000 claims 1
YXMQXPIQDBXJLV-UHFFFAOYSA-N 2-[2-[5-amino-2-(4-chlorophenyl)phenyl]quinolin-6-yl]-1-cyclohexylbenzimidazole-5-carboxylic acid Chemical compound C=1C=C2C=C(C=3N(C4=CC=C(C=C4N=3)C(O)=O)C3CCCCC3)C=CC2=NC=1C1=CC(N)=CC=C1C1=CC=C(Cl)C=C1 YXMQXPIQDBXJLV-UHFFFAOYSA-N 0.000 claims 1
NTVZXDAZLWEDPF-UHFFFAOYSA-N 2-[2-[5-carboxy-2-(4-chlorophenyl)phenyl]quinolin-6-yl]-1-cyclohexylbenzimidazole-5-carboxylic acid Chemical compound C=1C=C2C=C(C=3N(C4=CC=C(C=C4N=3)C(O)=O)C3CCCCC3)C=CC2=NC=1C1=CC(C(=O)O)=CC=C1C1=CC=C(Cl)C=C1 NTVZXDAZLWEDPF-UHFFFAOYSA-N 0.000 claims 1
YGFLSZNWUSUAHI-UHFFFAOYSA-N 2-[2-[5-chloro-2-(4-chlorophenyl)phenyl]quinolin-6-yl]-1-cyclohexylbenzimidazole-5-carboxylic acid Chemical compound C=1C=C2N=C(C=3C(=CC=C(Cl)C=3)C=3C=CC(Cl)=CC=3)C=CC2=CC=1C1=NC2=CC(C(=O)O)=CC=C2N1C1CCCCC1 YGFLSZNWUSUAHI-UHFFFAOYSA-N 0.000 claims 1
VKRRRNWSVAEUQU-UHFFFAOYSA-N 2-[2-[8-(4-chlorophenyl)-3,4-dihydro-2h-1,5-benzodioxepin-7-yl]quinolin-6-yl]-1-cyclohexylbenzimidazole-5-carboxylic acid Chemical compound C=1C=C2N=C(C=3C(=CC=4OCCCOC=4C=3)C=3C=CC(Cl)=CC=3)C=CC2=CC=1C1=NC2=CC(C(=O)O)=CC=C2N1C1CCCCC1 VKRRRNWSVAEUQU-UHFFFAOYSA-N 0.000 claims 1
PGUWUAPWOGZBEQ-UHFFFAOYSA-N 2-[2-[[1-amino-3-(1h-imidazol-2-yl)-1-oxopropan-2-yl]carbamoyl]quinolin-6-yl]-1-cyclohexylbenzimidazole-5-carboxylic acid Chemical compound C=1C=C2C=C(C=3N(C4=CC=C(C=C4N=3)C(O)=O)C3CCCCC3)C=CC2=NC=1C(=O)NC(C(=O)N)CC1=NC=CN1 PGUWUAPWOGZBEQ-UHFFFAOYSA-N 0.000 claims 1
XKXHBWGRQAVUNH-UHFFFAOYSA-N 2-[4-(4-chloroanilino)-2-phenylquinolin-6-yl]-1-cyclohexylbenzimidazole-5-carboxylic acid Chemical compound C=1C=C2N=C(C=3C=CC=CC=3)C=C(NC=3C=CC(Cl)=CC=3)C2=CC=1C1=NC2=CC(C(=O)O)=CC=C2N1C1CCCCC1 XKXHBWGRQAVUNH-UHFFFAOYSA-N 0.000 claims 1
IYCHXNIVAVHBBD-UHFFFAOYSA-N 2-[4-[[1-cyclohexyl-2-(2-phenylquinolin-6-yl)benzimidazole-5-carbonyl]amino]phenyl]acetic acid Chemical compound C1=CC(CC(=O)O)=CC=C1NC(=O)C1=CC=C(N(C2CCCCC2)C(=N2)C=3C=C4C=CC(=NC4=CC=3)C=3C=CC=CC=3)C2=C1 IYCHXNIVAVHBBD-UHFFFAOYSA-N 0.000 claims 1
PLEOETILPNENHG-UHFFFAOYSA-N 2-[6-(2-nitrophenyl)-5h-quinolin-6-yl]-3h-benzimidazole-5-carboxylic acid Chemical compound N=1C2=CC(C(=O)O)=CC=C2NC=1C1(C=CC2=NC=CC=C2C1)C1=CC=CC=C1[N+]([O-])=O PLEOETILPNENHG-UHFFFAOYSA-N 0.000 claims 1
KDTQPOABAUPTBI-UHFFFAOYSA-N 2-[[1-cyclohexyl-2-(2-methylquinolin-6-yl)benzimidazole-5-carbonyl]amino]-3-(5-hydroxy-1h-indol-3-yl)propanoic acid Chemical compound C1=CC2=NC(C)=CC=C2C=C1C1=NC2=CC(C(=O)NC(CC=3C4=CC(O)=CC=C4NC=3)C(O)=O)=CC=C2N1C1CCCCC1 KDTQPOABAUPTBI-UHFFFAOYSA-N 0.000 claims 1
RWCAYPBWDMQEPG-UHFFFAOYSA-N 2-[[1-cyclohexyl-2-(2-methylquinolin-6-yl)benzimidazole-5-carbonyl]amino]acetic acid Chemical compound C1=CC2=NC(C)=CC=C2C=C1C1=NC2=CC(C(=O)NCC(O)=O)=CC=C2N1C1CCCCC1 RWCAYPBWDMQEPG-UHFFFAOYSA-N 0.000 claims 1
PNTNNSIEIWJCNH-UHFFFAOYSA-N 2-[[1-cyclohexyl-2-(2-methylquinolin-6-yl)benzimidazole-5-carbonyl]amino]propanoic acid Chemical compound C=1C=C2N=C(C)C=CC2=CC=1C1=NC2=CC(C(=O)NC(C)C(O)=O)=CC=C2N1C1CCCCC1 PNTNNSIEIWJCNH-UHFFFAOYSA-N 0.000 claims 1
MMORODGQOMYNPM-UHFFFAOYSA-N 2-[[1-cyclohexyl-2-(2-methylquinoxalin-6-yl)benzimidazole-5-carbonyl]amino]acetic acid Chemical compound C1=CC2=NC(C)=CN=C2C=C1C1=NC2=CC(C(=O)NCC(O)=O)=CC=C2N1C1CCCCC1 MMORODGQOMYNPM-UHFFFAOYSA-N 0.000 claims 1
WGYQYJKQUFYKBO-UHFFFAOYSA-N 2-[[1-cyclohexyl-2-(2-methylquinoxalin-6-yl)benzimidazole-5-carbonyl]amino]propanoic acid Chemical compound C=1C=C2N=C(C)C=NC2=CC=1C1=NC2=CC(C(=O)NC(C)C(O)=O)=CC=C2N1C1CCCCC1 WGYQYJKQUFYKBO-UHFFFAOYSA-N 0.000 claims 1
QHNRETCFDWZBNA-UHFFFAOYSA-N 2-[[1-cyclohexyl-2-(2-phenylquinolin-6-yl)benzimidazole-5-carbonyl]amino]ethanesulfonic acid Chemical compound C=1C=C2N=C(C=3C=CC=CC=3)C=CC2=CC=1C1=NC2=CC(C(=O)NCCS(=O)(=O)O)=CC=C2N1C1CCCCC1 QHNRETCFDWZBNA-UHFFFAOYSA-N 0.000 claims 1
BHWNMHRXXUSLAL-UHFFFAOYSA-N 2-[[1-cyclohexyl-2-(2-phenylquinolin-6-yl)benzimidazole-5-carbonyl]amino]pentanedioic acid Chemical compound C=1C=C2N=C(C=3C=CC=CC=3)C=CC2=CC=1C1=NC2=CC(C(=O)NC(CCC(=O)O)C(O)=O)=CC=C2N1C1CCCCC1 BHWNMHRXXUSLAL-UHFFFAOYSA-N 0.000 claims 1
VMQUMQLGNYPDDZ-UHFFFAOYSA-N 2-[[1-cyclohexyl-2-(2-phenylquinolin-6-yl)benzimidazole-5-carbonyl]amino]thiophene-3-carboxylic acid Chemical compound C1=CSC(NC(=O)C=2C=C3N=C(N(C4CCCCC4)C3=CC=2)C=2C=C3C=CC(=NC3=CC=2)C=2C=CC=CC=2)=C1C(=O)O VMQUMQLGNYPDDZ-UHFFFAOYSA-N 0.000 claims 1
SPRZRSBWLZJDHZ-UHFFFAOYSA-N 2-[[1-cyclohexyl-2-(2-phenylquinoxalin-6-yl)benzimidazole-5-carbonyl]amino]-3-(1h-imidazol-5-yl)propanoic acid Chemical compound C=1C=C2N(C3CCCCC3)C(C=3C=C4N=CC(=NC4=CC=3)C=3C=CC=CC=3)=NC2=CC=1C(=O)NC(C(=O)O)CC1=CN=CN1 SPRZRSBWLZJDHZ-UHFFFAOYSA-N 0.000 claims 1
OQYVANUKSAZCJG-UHFFFAOYSA-N 2-[[1-cyclohexyl-2-(2-phenylquinoxalin-6-yl)benzimidazole-5-carbonyl]amino]-3-(4-hydroxyphenyl)propanoic acid Chemical compound C=1C=C2N(C3CCCCC3)C(C=3C=C4N=CC(=NC4=CC=3)C=3C=CC=CC=3)=NC2=CC=1C(=O)NC(C(=O)O)CC1=CC=C(O)C=C1 OQYVANUKSAZCJG-UHFFFAOYSA-N 0.000 claims 1
WTYBAJTVRUMNNW-UHFFFAOYSA-N 2-[[1-cyclohexyl-2-(2-phenylquinoxalin-6-yl)benzimidazole-5-carbonyl]amino]-3-(4-phenylphenyl)propanoic acid Chemical compound C=1C=C2N(C3CCCCC3)C(C=3C=C4N=CC(=NC4=CC=3)C=3C=CC=CC=3)=NC2=CC=1C(=O)NC(C(=O)O)CC(C=C1)=CC=C1C1=CC=CC=C1 WTYBAJTVRUMNNW-UHFFFAOYSA-N 0.000 claims 1
GMDXUBZAGWSUNV-UHFFFAOYSA-N 2-[[1-cyclohexyl-2-(2-phenylquinoxalin-6-yl)benzimidazole-5-carbonyl]amino]-3-(5-hydroxy-1h-indol-3-yl)propanoic acid Chemical compound C=1NC2=CC=C(O)C=C2C=1CC(C(=O)O)NC(=O)C(C=C1N=C2C=3C=C4N=CC(=NC4=CC=3)C=3C=CC=CC=3)=CC=C1N2C1CCCCC1 GMDXUBZAGWSUNV-UHFFFAOYSA-N 0.000 claims 1
DJSPBGXAKTZKEG-UHFFFAOYSA-N 2-[[1-cyclohexyl-2-(2-phenylquinoxalin-6-yl)benzimidazole-5-carbonyl]amino]-3-hydroxybutanoic acid Chemical compound C=1C=C2N=C(C=3C=CC=CC=3)C=NC2=CC=1C1=NC2=CC(C(=O)NC(C(O)C)C(O)=O)=CC=C2N1C1CCCCC1 DJSPBGXAKTZKEG-UHFFFAOYSA-N 0.000 claims 1
PXJMQKMBQSCXMN-UHFFFAOYSA-N 2-[[1-cyclohexyl-2-(2-phenylquinoxalin-6-yl)benzimidazole-5-carbonyl]amino]-3-methylbutanoic acid Chemical compound C=1C=C2N=C(C=3C=CC=CC=3)C=NC2=CC=1C1=NC2=CC(C(=O)NC(C(C)C)C(O)=O)=CC=C2N1C1CCCCC1 PXJMQKMBQSCXMN-UHFFFAOYSA-N 0.000 claims 1
MFFOWMKDRWONPB-UHFFFAOYSA-N 2-[[1-cyclohexyl-2-(2-phenylquinoxalin-6-yl)benzimidazole-5-carbonyl]amino]-3-methylpentanoic acid Chemical compound C=1C=C2N=C(C=3C=CC=CC=3)C=NC2=CC=1C1=NC2=CC(C(=O)NC(C(C)CC)C(O)=O)=CC=C2N1C1CCCCC1 MFFOWMKDRWONPB-UHFFFAOYSA-N 0.000 claims 1
QTEDBQSMMVGUHG-UHFFFAOYSA-N 2-[[1-cyclohexyl-2-(2-phenylquinoxalin-6-yl)benzimidazole-5-carbonyl]amino]-3-phenylpropanoic acid Chemical compound C=1C=C2N(C3CCCCC3)C(C=3C=C4N=CC(=NC4=CC=3)C=3C=CC=CC=3)=NC2=CC=1C(=O)NC(C(=O)O)CC1=CC=CC=C1 QTEDBQSMMVGUHG-UHFFFAOYSA-N 0.000 claims 1
VVGBMMRFBRVYLY-UHFFFAOYSA-N 2-[[1-cyclohexyl-2-(2-phenylquinoxalin-6-yl)benzimidazole-5-carbonyl]amino]-4-methylpentanoic acid Chemical compound C=1C=C2N=C(C=3C=CC=CC=3)C=NC2=CC=1C1=NC2=CC(C(=O)NC(CC(C)C)C(O)=O)=CC=C2N1C1CCCCC1 VVGBMMRFBRVYLY-UHFFFAOYSA-N 0.000 claims 1
KCVHQOROFACNLJ-UHFFFAOYSA-N 2-[[1-cyclohexyl-2-(2-phenylquinoxalin-6-yl)benzimidazole-5-carbonyl]amino]-4-methylsulfanylbutanoic acid Chemical compound C=1C=C2N=C(C=3C=CC=CC=3)C=NC2=CC=1C1=NC2=CC(C(=O)NC(CCSC)C(O)=O)=CC=C2N1C1CCCCC1 KCVHQOROFACNLJ-UHFFFAOYSA-N 0.000 claims 1
KBHVBCKUSKNZNH-UHFFFAOYSA-N 2-[[1-cyclohexyl-2-(2-phenylquinoxalin-6-yl)benzimidazole-5-carbonyl]amino]-5-(diaminomethylideneamino)pentanoic acid Chemical compound C=1C=C2N=C(C=3C=CC=CC=3)C=NC2=CC=1C1=NC2=CC(C(=O)NC(CCCNC(=N)N)C(O)=O)=CC=C2N1C1CCCCC1 KBHVBCKUSKNZNH-UHFFFAOYSA-N 0.000 claims 1
KYMSOANUKJLZSN-UHFFFAOYSA-N 2-[[1-cyclohexyl-2-(2-phenylquinoxalin-6-yl)benzimidazole-5-carbonyl]amino]acetic acid Chemical compound C=1C=C2N=C(C=3C=CC=CC=3)C=NC2=CC=1C1=NC2=CC(C(=O)NCC(=O)O)=CC=C2N1C1CCCCC1 KYMSOANUKJLZSN-UHFFFAOYSA-N 0.000 claims 1
GTJAOGGEZJKHPY-UHFFFAOYSA-N 2-[[1-cyclohexyl-2-(2-phenylquinoxalin-6-yl)benzimidazole-5-carbonyl]amino]butanedioic acid Chemical compound C=1C=C2N=C(C=3C=CC=CC=3)C=NC2=CC=1C1=NC2=CC(C(=O)NC(CC(=O)O)C(O)=O)=CC=C2N1C1CCCCC1 GTJAOGGEZJKHPY-UHFFFAOYSA-N 0.000 claims 1
GSBNUVZTRXXSIG-UHFFFAOYSA-N 2-[[1-cyclohexyl-2-(2-phenylquinoxalin-6-yl)benzimidazole-5-carbonyl]amino]ethanesulfonic acid Chemical compound C=1C=C2N=C(C=3C=CC=CC=3)C=NC2=CC=1C1=NC2=CC(C(=O)NCCS(=O)(=O)O)=CC=C2N1C1CCCCC1 GSBNUVZTRXXSIG-UHFFFAOYSA-N 0.000 claims 1
YBEJMVLBJRFEKF-UHFFFAOYSA-N 2-[[1-cyclohexyl-2-(2-phenylquinoxalin-6-yl)benzimidazole-5-carbonyl]amino]pentanedioic acid Chemical compound C=1C=C2N=C(C=3C=CC=CC=3)C=NC2=CC=1C1=NC2=CC(C(=O)NC(CCC(=O)O)C(O)=O)=CC=C2N1C1CCCCC1 YBEJMVLBJRFEKF-UHFFFAOYSA-N 0.000 claims 1
KXIFHBMAESWLSC-UHFFFAOYSA-N 2-[[1-cyclohexyl-2-(2-phenylquinoxalin-6-yl)benzimidazole-5-carbonyl]amino]propanoic acid Chemical compound C=1C=C2N=C(C=3C=CC=CC=3)C=NC2=CC=1C1=NC2=CC(C(=O)NC(C)C(O)=O)=CC=C2N1C1CCCCC1 KXIFHBMAESWLSC-UHFFFAOYSA-N 0.000 claims 1
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DVVYHIVXRDBXBN-UHFFFAOYSA-N 2-[[1-cyclohexyl-2-(3-phenylquinolin-7-yl)benzimidazole-5-carbonyl]amino]-3-(5-hydroxy-1h-indol-3-yl)propanoic acid Chemical compound C=1NC2=CC=C(O)C=C2C=1CC(C(=O)O)NC(=O)C(C=C1N=C2C=3C=C4N=CC(=CC4=CC=3)C=3C=CC=CC=3)=CC=C1N2C1CCCCC1 DVVYHIVXRDBXBN-UHFFFAOYSA-N 0.000 claims 1
VAVBSZURQPMLMR-UHFFFAOYSA-N 2-[[1-cyclohexyl-2-(3-phenylquinoxalin-6-yl)benzimidazole-5-carbonyl]amino]-3-(5-hydroxy-1h-indol-3-yl)propanoic acid Chemical compound C=1NC2=CC=C(O)C=C2C=1CC(C(=O)O)NC(=O)C(C=C1N=C2C=3C=C4N=C(C=NC4=CC=3)C=3C=CC=CC=3)=CC=C1N2C1CCCCC1 VAVBSZURQPMLMR-UHFFFAOYSA-N 0.000 claims 1
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LHIIKOCMMJXNBT-UHFFFAOYSA-N 2-[[2-[2-[2-(4-chlorophenyl)-5-(pyrrolidine-1-carbonyl)phenyl]quinolin-6-yl]-1-cyclohexylbenzimidazole-5-carbonyl]amino]-3-(5-hydroxy-1h-indol-3-yl)propanoic acid Chemical compound C=1NC2=CC=C(O)C=C2C=1CC(C(=O)O)NC(=O)C(C=C1N=C2C=3C=C4C=CC(=NC4=CC=3)C=3C(=CC=C(C=3)C(=O)N3CCCC3)C=3C=CC(Cl)=CC=3)=CC=C1N2C1CCCCC1 LHIIKOCMMJXNBT-UHFFFAOYSA-N 0.000 claims 1
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125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 claims 1
125000004172 4-methoxyphenyl group Chemical group [H]C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1* 0.000 claims 1
125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 claims 1
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NMRNAGLDCZMCQX-UHFFFAOYSA-N 6-(1-cyclohexyl-5-ethoxycarbonylbenzimidazol-2-yl)quinoline-2-carboxylic acid Chemical compound C=1C=C2N=C(C(O)=O)C=CC2=CC=1C1=NC2=CC(C(=O)OCC)=CC=C2N1C1CCCCC1 NMRNAGLDCZMCQX-UHFFFAOYSA-N 0.000 claims 1
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ICAJHKYWCWQILE-UHFFFAOYSA-N 6-[[1-cyclohexyl-2-(2-phenylquinoxalin-6-yl)benzimidazole-5-carbonyl]amino]naphthalene-2-carboxylic acid Chemical compound C1=CC2=CC(C(=O)O)=CC=C2C=C1NC(=O)C(C=C1N=C2C=3C=C4N=CC(=NC4=CC=3)C=3C=CC=CC=3)=CC=C1N2C1CCCCC1 ICAJHKYWCWQILE-UHFFFAOYSA-N 0.000 claims 1
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SMFZBTRPVLODMX-UHFFFAOYSA-N 7-[1-cyclohexyl-5-(2h-tetrazol-5-yl)benzimidazol-2-yl]-3-methyl-2h-phthalazine-1,4-dione Chemical compound C=1C=C2C(=O)N(C)NC(=O)C2=CC=1C1=NC2=CC(C=3NN=NN=3)=CC=C2N1C1CCCCC1 SMFZBTRPVLODMX-UHFFFAOYSA-N 0.000 claims 1
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MXODZNXZOMDOCB-UHFFFAOYSA-N [4-(4-chlorophenyl)-3-[6-[1-cyclohexyl-5-(2h-tetrazol-5-yl)benzimidazol-2-yl]quinolin-2-yl]phenyl]-pyrrolidin-1-ylmethanone Chemical compound C1=CC(Cl)=CC=C1C1=CC=C(C(=O)N2CCCC2)C=C1C1=CC=C(C=C(C=C2)C=3N(C4=CC=C(C=C4N=3)C=3NN=NN=3)C3CCCCC3)C2=N1 MXODZNXZOMDOCB-UHFFFAOYSA-N 0.000 claims 1
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125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 1
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UKJLNMAFNRKWGR-UHFFFAOYSA-N cyclohexatrienamine Chemical group NC1=CC=C=C[CH]1 UKJLNMAFNRKWGR-UHFFFAOYSA-N 0.000 claims 1
125000004210 cyclohexylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 1
125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 1
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125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
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QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 1
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125000001042 pteridinyl group Chemical group N1=C(N=CC2=NC=CN=C12)* 0.000 claims 1
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125000002294 quinazolinyl group Chemical group N1=C(N=CC2=CC=CC=C12)* 0.000 claims 1
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229910052717 sulfur Inorganic materials 0.000 claims 1
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NZVYCXVTEHPMHE-ZSUJOUNUSA-N thymalfasin Chemical compound CC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O NZVYCXVTEHPMHE-ZSUJOUNUSA-N 0.000 claims 1
229960004231 thymalfasin Drugs 0.000 claims 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1

JP2006522111A 2003-08-01 2004-07-30 フラビウイルス科に対する二環式イミダゾール誘導体 Withdrawn JP2007501189A (ja)