MX355623B - Hidrazino-1h-imidazoquinolin-4-aminas y conjugados elaborados a partir de las mismas. - Google Patents

Hidrazino-1h-imidazoquinolin-4-aminas y conjugados elaborados a partir de las mismas.

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Publication number
MX355623B
MX355623B MX2013014145A MX2013014145A MX355623B MX 355623 B MX355623 B MX 355623B MX 2013014145 A MX2013014145 A MX 2013014145A MX 2013014145 A MX2013014145 A MX 2013014145A MX 355623 B MX355623 B MX 355623B
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MX
Mexico
Prior art keywords
amines
imidazoquinolin
hydrazino
made therefrom
conjugates made
Prior art date
Application number
MX2013014145A
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English (en)
Other versions
MX2013014145A (es
Inventor
D Wightman Paul
Original Assignee
3M Innovative Properties Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 3M Innovative Properties Co filed Critical 3M Innovative Properties Co
Publication of MX2013014145A publication Critical patent/MX2013014145A/es
Publication of MX355623B publication Critical patent/MX355623B/es

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
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    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

Se describen las 1H-imidazo[4,5-c]quinolin-4-aminas sustituidas en la posición 1 con un sustituyente que posee una hidrazinobenzamida o hidrazino nicotinamida, una sal del mismo, o una hidrazinobenzamida o hidrazinonicotinamida protegida, y conjugados elaborados a partir de tales compuestos. Se describen también las composiciones farmacéuticas que contienen el compuesto o el conjugado, los métodos de elaboración de un conjugado, y los métodos de uso de los compuestos o conjugados como inmunomoduladores para inducir la biosíntesis de citocina en un animal, y para vacunar a un animal.
MX2013014145A 2011-06-03 2012-06-01 Hidrazino-1h-imidazoquinolin-4-aminas y conjugados elaborados a partir de las mismas. MX355623B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161493143P 2011-06-03 2011-06-03
US201161493051P 2011-06-03 2011-06-03
PCT/US2012/040461 WO2012167081A1 (en) 2011-06-03 2012-06-01 Hydrazino 1h-imidazoquinolin-4-amines and conjugates made therefrom

Publications (2)

Publication Number Publication Date
MX2013014145A MX2013014145A (es) 2014-01-31
MX355623B true MX355623B (es) 2018-04-25

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Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013014145A MX355623B (es) 2011-06-03 2012-06-01 Hidrazino-1h-imidazoquinolin-4-aminas y conjugados elaborados a partir de las mismas.

Country Status (10)

Country Link
US (3) US9107958B2 (es)
EP (3) EP3366311B1 (es)
JP (3) JP6415979B2 (es)
CN (1) CN103582640B (es)
AU (1) AU2012261959B2 (es)
BR (1) BR112013031039B1 (es)
CA (1) CA2838023C (es)
MX (1) MX355623B (es)
WO (1) WO2012167081A1 (es)
ZA (1) ZA201309687B (es)

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