BR112013031039B1 - compostos de hidrazino 1h-imidazoquinolina-4-aminas, conjugados feitos destes compostos, composição e composição farmacêutica compreendendo ditos compostos e conjugados, usos dos mesmos e método de fabricação do conjugado - Google Patents
compostos de hidrazino 1h-imidazoquinolina-4-aminas, conjugados feitos destes compostos, composição e composição farmacêutica compreendendo ditos compostos e conjugados, usos dos mesmos e método de fabricação do conjugado Download PDFInfo
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
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- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
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Abstract
resumo hidrazino 1h-imidazoquinolina-4-aminas e conjugados feitos disso 1h-imidazo[4,5-c]quinolin-4-aminas substituídas na posição 1 por um substituinte contendo uma hidrazinobenzamida ou hidrazinonicotinamida, um sal da mesma ou uma hidrazinonicotinamida ou hidrazinobenzamida protegida e conjugados produzidos a partir de tais compostos são apresentados. as composições farmacêuticas contendo o composto ou o conjugado, métodos de preparo de um conjugado e métodos para o uso dos compostos ou conjugados como imunomoduladores para induzir a biossíntese de citoquina em um animal e para vacinar um animal também são apresentados.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161493051P | 2011-06-03 | 2011-06-03 | |
US201161493143P | 2011-06-03 | 2011-06-03 | |
PCT/US2012/040461 WO2012167081A1 (en) | 2011-06-03 | 2012-06-01 | Hydrazino 1h-imidazoquinolin-4-amines and conjugates made therefrom |
Publications (2)
Publication Number | Publication Date |
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BR112013031039A2 BR112013031039A2 (pt) | 2016-11-29 |
BR112013031039B1 true BR112013031039B1 (pt) | 2020-04-28 |
Family
ID=47259897
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112013031039A BR112013031039B1 (pt) | 2011-06-03 | 2012-06-01 | compostos de hidrazino 1h-imidazoquinolina-4-aminas, conjugados feitos destes compostos, composição e composição farmacêutica compreendendo ditos compostos e conjugados, usos dos mesmos e método de fabricação do conjugado |
Country Status (10)
Country | Link |
---|---|
US (3) | US9107958B2 (pt) |
EP (3) | EP2718292B1 (pt) |
JP (3) | JP6415979B2 (pt) |
CN (1) | CN103582640B (pt) |
AU (1) | AU2012261959B2 (pt) |
BR (1) | BR112013031039B1 (pt) |
CA (1) | CA2838023C (pt) |
MX (1) | MX355623B (pt) |
WO (1) | WO2012167081A1 (pt) |
ZA (1) | ZA201309687B (pt) |
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JP5043435B2 (ja) | 2003-10-03 | 2012-10-10 | スリーエム イノベイティブ プロパティズ カンパニー | アルコキシ置換イミダゾキノリン |
US8541438B2 (en) | 2004-06-18 | 2013-09-24 | 3M Innovative Properties Company | Substituted imidazoquinolines, imidazopyridines, and imidazonaphthyridines |
HUE033901T2 (en) | 2010-08-17 | 2018-01-29 | 3M Innovative Properties Co | Formulations and formulations for lipidized immune response modifying compounds and related processes |
BR112013031039B1 (pt) * | 2011-06-03 | 2020-04-28 | 3M Innovative Properties Co | compostos de hidrazino 1h-imidazoquinolina-4-aminas, conjugados feitos destes compostos, composição e composição farmacêutica compreendendo ditos compostos e conjugados, usos dos mesmos e método de fabricação do conjugado |
JP6460789B2 (ja) | 2011-06-03 | 2019-01-30 | スリーエム イノベイティブ プロパティズ カンパニー | ポリエチレングリコールセグメントを有するヘテロ2官能性リンカー及び該リンカーから調製された免疫反応調節複合体 |
WO2014152818A1 (en) | 2013-03-14 | 2014-09-25 | The University Of Massachusetts | Methods of inhibiting cataracts and presbyopia |
WO2015023649A2 (en) | 2013-08-12 | 2015-02-19 | 3M Innovative Properties Company | Peptides for enhancing transdermal delivery |
CN105873587B (zh) | 2013-11-05 | 2020-07-21 | 3M创新有限公司 | 基于芝麻油的注射配制品 |
AR100137A1 (es) | 2014-04-22 | 2016-09-14 | Hoffmann La Roche | Compuestos 4-amino-imidazoquinolina |
CN107295798B (zh) | 2015-03-06 | 2020-10-30 | 豪夫迈·罗氏有限公司 | 苯并氮杂*二甲酰胺化合物 |
WO2016183371A1 (en) | 2015-05-13 | 2016-11-17 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Methods for the treatment or prevention of ischemic tissue damage |
WO2017046112A1 (en) | 2015-09-17 | 2017-03-23 | F. Hoffmann-La Roche Ag | Sulfinylphenyl or sulfonimidoylphenyl benzazepines |
EP3356371A4 (en) * | 2015-09-29 | 2020-06-24 | The University of Chicago | POLYMER CONJUGATE VACCINE |
ES2745291T3 (es) * | 2015-11-13 | 2020-02-28 | Univ Massachusetts | Moléculas difuncionales que contienen PEG para su uso en la inhibición de cataratas y presbicia |
JP7022702B2 (ja) | 2016-05-23 | 2022-02-18 | エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト | 第二級アミド基を有するベンズアゼピンジカルボキサミド化合物 |
CN109153648B (zh) | 2016-05-23 | 2022-07-22 | 豪夫迈·罗氏有限公司 | 具有叔酰胺官能团的苯并氮杂卓二甲酰胺化合物 |
EP3468963B1 (en) | 2016-06-12 | 2021-10-27 | F. Hoffmann-La Roche AG | Dihydropyrimidinyl benzazepine carboxamide compounds |
CN115317603A (zh) | 2016-07-07 | 2022-11-11 | 小利兰·斯坦福大学托管委员会 | 抗体佐剂缀合物 |
US10729763B2 (en) | 2017-06-10 | 2020-08-04 | Inventprise, Llc | Mixtures of polysaccharide-protein pegylated compounds |
WO2019047824A1 (zh) * | 2017-09-05 | 2019-03-14 | 浙江海正药业股份有限公司 | 新型咪唑喹啉化合物及其制备方法和用途 |
EP3728255B1 (en) | 2017-12-20 | 2022-01-26 | 3M Innovative Properties Company | Amide substituted imidazo[4,5-c]quinoline compounds with a branched chain linking group for use as an immune response modifier |
KR20210141461A (ko) | 2019-02-01 | 2021-11-23 | 캔웰 바이오테크 리미티드 | 이미다조퀴놀린 아민 유도체, 약제학적 조성물, 이의 용도 |
WO2020190725A1 (en) | 2019-03-15 | 2020-09-24 | Bolt Biotherapeutics, Inc. | Immunoconjugates targeting her2 |
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EP2718292B1 (en) | 2018-03-14 |
EP2718292A1 (en) | 2014-04-16 |
EP3366311B1 (en) | 2020-02-26 |
JP2014515406A (ja) | 2014-06-30 |
CN103582640B (zh) | 2015-11-25 |
AU2012261959B2 (en) | 2015-12-03 |
WO2012167081A1 (en) | 2012-12-06 |
JP6430574B2 (ja) | 2018-11-28 |
CA2838023A1 (en) | 2012-12-06 |
EP3153180A1 (en) | 2017-04-12 |
EP2718292A4 (en) | 2014-10-15 |
US9107958B2 (en) | 2015-08-18 |
MX355623B (es) | 2018-04-25 |
US20150352218A1 (en) | 2015-12-10 |
AU2012261959A1 (en) | 2013-12-19 |
JP2017160219A (ja) | 2017-09-14 |
US20140286988A1 (en) | 2014-09-25 |
US20170173164A1 (en) | 2017-06-22 |
ZA201309687B (en) | 2015-05-27 |
EP3366311A1 (en) | 2018-08-29 |
BR112013031039A2 (pt) | 2016-11-29 |
JP6415979B2 (ja) | 2018-10-31 |
MX2013014145A (es) | 2014-01-31 |
US10406142B2 (en) | 2019-09-10 |
JP2017160220A (ja) | 2017-09-14 |
CN103582640A (zh) | 2014-02-12 |
US9585968B2 (en) | 2017-03-07 |
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