JP2007537272A5 - - Google Patents

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Publication number
JP2007537272A5
JP2007537272A5 JP2007513317A JP2007513317A JP2007537272A5 JP 2007537272 A5 JP2007537272 A5 JP 2007537272A5 JP 2007513317 A JP2007513317 A JP 2007513317A JP 2007513317 A JP2007513317 A JP 2007513317A JP 2007537272 A5 JP2007537272 A5 JP 2007537272A5
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JP
Japan
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substituted
unsubstituted
group
alkyl
medicament
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
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JP2007513317A
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English (en)
Japanese (ja)
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JP2007537272A (ja
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Priority claimed from PCT/US2005/016507 external-priority patent/WO2005113534A2/en
Publication of JP2007537272A publication Critical patent/JP2007537272A/ja
Publication of JP2007537272A5 publication Critical patent/JP2007537272A5/ja
Ceased legal-status Critical Current

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JP2007513317A 2004-05-12 2005-05-11 Cxcr1およびcxcr2ケモカインアンタゴニスト Ceased JP2007537272A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US57032604P 2004-05-12 2004-05-12
PCT/US2005/016507 WO2005113534A2 (en) 2004-05-12 2005-05-11 Cxcr1 and cxcr2 chemokine antagonists

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2011224353A Division JP2012006982A (ja) 2004-05-12 2011-10-11 Cxcr1およびcxcr2ケモカインアンタゴニスト

Publications (2)

Publication Number Publication Date
JP2007537272A JP2007537272A (ja) 2007-12-20
JP2007537272A5 true JP2007537272A5 (https=) 2011-12-01

Family

ID=35149666

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2007513317A Ceased JP2007537272A (ja) 2004-05-12 2005-05-11 Cxcr1およびcxcr2ケモカインアンタゴニスト
JP2011224353A Withdrawn JP2012006982A (ja) 2004-05-12 2011-10-11 Cxcr1およびcxcr2ケモカインアンタゴニスト

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2011224353A Withdrawn JP2012006982A (ja) 2004-05-12 2011-10-11 Cxcr1およびcxcr2ケモカインアンタゴニスト

Country Status (11)

Country Link
US (2) US7326729B2 (https=)
EP (1) EP1745032B1 (https=)
JP (2) JP2007537272A (https=)
KR (1) KR20070011475A (https=)
CN (1) CN1984899B (https=)
AU (1) AU2005245399A1 (https=)
CA (1) CA2565519A1 (https=)
IL (1) IL179162A0 (https=)
MX (1) MXPA06013118A (https=)
WO (1) WO2005113534A2 (https=)
ZA (1) ZA200609237B (https=)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102005008183A1 (de) * 2005-02-23 2006-08-31 Bayer Healthcare Ag Heterocyclylamid-substituierte Imidazole
AR060562A1 (es) * 2006-04-21 2008-06-25 Smithkline Beecham Corp Compuestos heterociclicos como antagonistas del receptor il-8. procesos de obtencion y composiciones farmaceuticas.
UA95480C2 (uk) * 2006-06-08 2011-08-10 Елі Ліллі Енд Компані Заміщені карбоксаміди
WO2008039876A1 (en) * 2006-09-26 2008-04-03 Case Western Reserve University Cytokine signaling
DE602007009865D1 (de) * 2006-11-23 2010-11-25 Novartis Ag 5-sulfanylmethylä1,2,4ütriazolä1,5-aüpyrimidin-7-olderivate als cxcr2-antagonisten
CA2669579A1 (en) * 2006-11-23 2008-05-29 Novartis Ag 5-sulfanylmethyl-pyrazolo [1,5-a] pyrimidin-7-ol derivatives as cxcr2 antagonists
KR20090115749A (ko) 2007-02-26 2009-11-05 산텐 세이야꾸 가부시키가이샤 우레이드기와 아미노카르보닐기를 치환기로서 갖는 신규 피롤 유도체
WO2009026248A2 (en) * 2007-08-17 2009-02-26 The Government Of The United States, As Represented By The Secretary Of Health And Human Services, National Institutes Of Health, Office Of Technology Transfer Hydrazide, amide, phthalimide and phthalhydrazide analogs as inhibitors of retroviral integrase
KR101039235B1 (ko) * 2007-08-29 2011-06-07 메디포스트(주) 제대혈 유래 간엽줄기세포를 포함하는 인터루킨-8 또는지알오-알파 발현 세포가 관련된 질병의 진단, 예방 또는치료용 조성물
GB2455539B (en) * 2007-12-12 2012-01-18 Cambridge Entpr Ltd Anti-inflammatory compositions and combinations
JP2010043063A (ja) * 2008-05-09 2010-02-25 Agency For Science Technology & Research 川崎病の診断及び治療
PT2356462T (pt) 2008-11-11 2017-04-07 Univ Michigan Regents Composições e métodos anti-cxcr1
CN106243023A (zh) * 2010-09-03 2016-12-21 福马Tm有限责任公司 用于抑制nampt的胍化合物和组合物
ES2688081T3 (es) * 2011-06-13 2018-10-30 Tla Targeted Immunotherapies Ab Tratamiento de dolencias asociadas a septicemia
AU2013240224A1 (en) 2012-03-30 2014-10-16 Sloan-Kettering Institute For Cancer Research S100A8/A9 as a diagnostic marker and a therapeutic target
WO2014062511A1 (en) * 2012-10-15 2014-04-24 Agios Pharmaceuticals, Inc. Therapeutic compounds and compositions
US8865723B2 (en) 2012-10-25 2014-10-21 Tetra Discovery Partners Llc Selective PDE4 B inhibition and improvement in cognition in subjects with brain injury
WO2014205127A2 (en) 2013-06-18 2014-12-24 New York University Cellular factors involved in the cytotoxicity of staphylococcus aureus leukocidins: novel therapeutic targets
WO2015054117A1 (en) * 2013-10-08 2015-04-16 Temple University-Of The Commonwealth System Of Higher Education Functionalized furan-2-sulfonamides exhibiting endothelial lipase inhibition
US9763992B2 (en) 2014-02-13 2017-09-19 Father Flanagan's Boys' Home Treatment of noise induced hearing loss
JP6667187B2 (ja) 2014-09-26 2020-03-18 シファ バイオメディカル コーポレーション 抗内皮リパーゼ化合物並びに心血管疾患の治療および/または予防におけるその使用方法
WO2017040742A1 (en) * 2015-09-04 2017-03-09 Dow Agrosciences Llc Molecules having pesticidal utility, and intermediates, compositions, and processes, related thereto
JP7092356B2 (ja) * 2016-06-22 2022-06-28 フーダン ユニヴァーシティ ビアリール尿素誘導体またはそれらの塩、およびそれらの調製方法および使用
WO2018071687A1 (en) * 2016-10-13 2018-04-19 The Regents Of The University Of California Methods of treating pruritis
US10610104B2 (en) 2016-12-07 2020-04-07 Progenity, Inc. Gastrointestinal tract detection methods, devices and systems
CA3045310A1 (en) 2016-12-14 2018-06-21 Progenity, Inc. Treatment of a disease of the gastrointestinal tract with a chemokine/chemokine receptor inhibitor
US20220249814A1 (en) 2018-11-19 2022-08-11 Progenity, Inc. Methods and devices for treating a disease with biotherapeutics
CN121197633A (zh) 2019-12-13 2025-12-26 比特比德科有限责任公司 用于将治疗剂递送至胃肠道的可摄取装置

Family Cites Families (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3529247A1 (de) * 1985-05-17 1986-11-20 Bayer Ag, 5090 Leverkusen Verwendung von thienylharnstoffen und -isoharnstoffen als leistungsfoerdernde mittel bei tieren, neue thienylharnstoffe und -isoharnstoffe und ihre herstellung
EP0255297B1 (en) 1986-07-31 1993-04-21 Beecham Group Plc Azabicyclic compounds, process for their preparation, and their pharmaceutical use
DE4412334A1 (de) * 1994-04-11 1995-10-19 Hoechst Ag Substituierte N-Heteroaroylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
US5780483A (en) 1995-02-17 1998-07-14 Smithkline Beecham Corporation IL-8 receptor antagonists
EP0809492A4 (en) 1995-02-17 2007-01-24 Smithkline Beecham Corp IL-8 RECEPTOR ANTAGONISTS
WO1997049399A1 (en) 1996-06-27 1997-12-31 Smithkline Beecham Corporation Il-8 receptor antagonists
EP0932405A4 (en) 1996-06-27 2001-10-17 Smithkline Beckman Corp IL-8 RECEPTOR ANTAGONISTS
JP2000514049A (ja) 1996-06-27 2000-10-24 スミスクライン・ビーチャム・コーポレイション Il―8受容体拮抗薬
CZ425698A3 (cs) 1996-06-27 1999-06-16 Smithkline Beecham Corporation Antagonista IL-8 receptoru
JP2000515495A (ja) 1996-06-27 2000-11-21 スミスクライン・ビーチャム・コーポレイション Il―8レセプターアンタゴニスト
WO1998005328A1 (en) 1996-08-06 1998-02-12 Smithkline Beecham Corporation Il-8 receptor antagonists
EP0934066A4 (en) 1996-08-06 2001-10-17 Smithkline Beecham Corp IL-8 RECEPTOR ANTAGONISTS
US6248785B1 (en) 1996-08-06 2001-06-19 Smithkline Beecham Corporation IL-8 receptor antagonists
JP2000516620A (ja) 1996-08-15 2000-12-12 スミスクライン・ビーチャム・コーポレイション Il―8レセプターアンタゴニスト
AR008290A1 (es) 1996-08-15 1999-12-29 Smithkline Beecham Corp Nuevos compuestos que contienen guanidina utiles como antagonistas de los receptores de il-8, composiciones farmaceuticas que los contienenprocedimiento para la preparacion de dichos compuestos y procedimiento para la preparacion de intermediarios.
JP2001527519A (ja) 1996-08-15 2001-12-25 スミスクライン・ビーチャム・コーポレイション Il―8レセプターアンタゴニスト
US6335352B1 (en) 1996-08-15 2002-01-01 Smithkline Beecham Corporation IL-8 receptor antagonists
EP1019035A4 (en) 1996-08-21 2001-10-17 Smithkline Beecham Corp IL-8 RECEPTOR ANTAGONISTS
AR008331A1 (es) 1997-01-23 1999-12-29 Smithkline Beecham Corp Compuestos antagonistas de un receptor de il-8, uso de los mismos para la fabricacion de medicamentos, procedimiento para su obtencion, composicionesfarmaceuticas que los contienen
BR9807083A (pt) 1997-01-23 2000-04-18 Smithkline Beckman Corp Antagonistas ao receptor de il-8
AR015425A1 (es) 1997-09-05 2001-05-02 Smithkline Beecham Corp Compuestos de benzotiazol, composicion farmaceutica que los contiene, su uso en la manufactura de un medicamento, procedimiento para su preparacion,compuestos intermediarios y procedimiento para su preparacion
AR015426A1 (es) 1997-09-05 2001-05-02 Smithkline Beecham Corp Compuestos de benzotiazol antagonistas del receptor de il-8, composicion farmaceutica que los contiene, su uso para la manufactura de un medicamento,procedimiento para su preparacion, compuestos intermediarios y procedimiento para su preparacion
SK286213B6 (sk) * 1997-12-22 2008-05-06 Bayer Corporation Substituované heterocyklické močoviny, farmaceutický prípravok ich obsahujúci a ich použitie
JP2002509106A (ja) 1998-01-20 2002-03-26 スミスクライン・ビーチャム・コーポレイション Il−8受容体アンタゴニスト
US6525069B1 (en) * 1998-12-18 2003-02-25 Bristol-Myers Squibb Pharma Co. N-ureidoalkyl-piperidines as modulators of chemokine receptor activity
ECSP003527A (es) 1999-06-16 2002-01-25 Smithkline Beecham Corp Antagonistas del receptor de il - 8 v
CO5200760A1 (es) * 1999-06-16 2002-09-27 Smithkline Beecham Corp Antagonistas del receptor de la il-8 ceptor il-8
AU6230300A (en) * 1999-07-21 2001-02-13 Kadmus Pharmaceuticals, Inc. Substituted guanidines and the use thereof
DE60006057T2 (de) 1999-12-03 2004-05-27 Pfizer Products Inc., Groton Heteroarylphenylpyrazolverbindungen zur Verwendung als analgetisches/entzündungshemmendes Mittel
AU2001241896A1 (en) 2000-03-01 2001-09-12 Smith Kline Beecham Corporation Il-8 receptor antagonists
EP1265905A4 (en) 2000-03-01 2003-03-12 Smithkline Beecham Corp IL-2 RECEPTOR ANTAGONISTS
AR031098A1 (es) 2000-03-16 2003-09-10 Smithkline Beecham Corp Compuestos de hidroxifenil urea sustituidos con sulfonamidas, composiciones farmaceuticas que los comprenden, y uso de los mismos en la fabricacion de medicamentos para tratar una enfermedad mediada por una quimioquina
UY26627A1 (es) 2000-03-24 2001-09-28 Smithkline Beecham Corp Antagonistas de receptores de il-8
EP1294690A2 (en) * 2000-06-21 2003-03-26 Bristol-Myers Squibb Pharma Company N-ureidoalkyl-piperidines as modulators of chemokine receptor activity
RU2003126913A (ru) 2001-02-02 2005-03-10 Шеринг Корпорейшн (US) 3,4-дизамещенные циклобутен-1,2-дионы, как антагонисты хемокинового рецептора схс
US7132445B2 (en) 2001-04-16 2006-11-07 Schering Corporation 3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands
US20040106794A1 (en) * 2001-04-16 2004-06-03 Schering Corporation 3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands
EP1270551A1 (en) * 2001-06-26 2003-01-02 Aventis Pharma Deutschland GmbH Urea derivatives with antiproteolytic activity
AUPR738301A0 (en) * 2001-08-30 2001-09-20 Starpharma Limited Chemotherapeutic agents
JP2005505595A (ja) 2001-10-12 2005-02-24 シェーリング コーポレイション Cxc−ケモカインレセプターアンタゴニストとしての3,4−二置換マレイミド化合物
US6878709B2 (en) 2002-01-04 2005-04-12 Schering Corporation 3,4-di-substituted pyridazinediones as CXC chemokine receptor antagonists
US20040053953A1 (en) * 2002-03-18 2004-03-18 Schering Corporation Treatment of chemokine mediated diseases
EP1402888A1 (en) * 2002-09-18 2004-03-31 Jerini AG The use of substituted carbocyclic compounds as rotamases inhibitors
MY139601A (en) 2002-10-09 2009-10-30 Schering Corp Thiadiazoledioxides and thiadiazoleoxides as cxc-and cc-chemokine receptor ligands
MXPA06007076A (es) 2003-12-19 2006-08-31 Pharmacopeia Drug Discovery Tiadiazoles como ligandos del receptor cxc y cc-quimiocina.
CA2550540A1 (en) * 2003-12-22 2005-07-28 Schering Corporation Isothiazole dioxides as cxc- and cc- chemokine receptor ligands
MX2008000366A (es) * 2005-06-29 2008-03-07 Schering Corp Oxadiazoles di-sustituidos como ligandos del receptor cxc-quimiocina.
JP2009500328A (ja) * 2005-06-29 2009-01-08 シェーリング コーポレイション Cxc−ケモカインレセプターリガンドとしての5,6−ジ−置換オキサジアゾロピラジンおよびチアジアゾロピラジン

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