JP2007537272A5 - - Google Patents

Download PDF

Info

Publication number
JP2007537272A5
JP2007537272A5 JP2007513317A JP2007513317A JP2007537272A5 JP 2007537272 A5 JP2007537272 A5 JP 2007537272A5 JP 2007513317 A JP2007513317 A JP 2007513317A JP 2007513317 A JP2007513317 A JP 2007513317A JP 2007537272 A5 JP2007537272 A5 JP 2007537272A5
Authority
JP
Japan
Prior art keywords
substituted
unsubstituted
group
alkyl
medicament
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
JP2007513317A
Other languages
English (en)
Japanese (ja)
Other versions
JP2007537272A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2005/016507 external-priority patent/WO2005113534A2/en
Publication of JP2007537272A publication Critical patent/JP2007537272A/ja
Publication of JP2007537272A5 publication Critical patent/JP2007537272A5/ja
Ceased legal-status Critical Current

Links

JP2007513317A 2004-05-12 2005-05-11 Cxcr1およびcxcr2ケモカインアンタゴニスト Ceased JP2007537272A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US57032604P 2004-05-12 2004-05-12
PCT/US2005/016507 WO2005113534A2 (en) 2004-05-12 2005-05-11 Cxcr1 and cxcr2 chemokine antagonists

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2011224353A Division JP2012006982A (ja) 2004-05-12 2011-10-11 Cxcr1およびcxcr2ケモカインアンタゴニスト

Publications (2)

Publication Number Publication Date
JP2007537272A JP2007537272A (ja) 2007-12-20
JP2007537272A5 true JP2007537272A5 (https=) 2011-12-01

Family

ID=35149666

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2007513317A Ceased JP2007537272A (ja) 2004-05-12 2005-05-11 Cxcr1およびcxcr2ケモカインアンタゴニスト
JP2011224353A Withdrawn JP2012006982A (ja) 2004-05-12 2011-10-11 Cxcr1およびcxcr2ケモカインアンタゴニスト

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2011224353A Withdrawn JP2012006982A (ja) 2004-05-12 2011-10-11 Cxcr1およびcxcr2ケモカインアンタゴニスト

Country Status (11)

Country Link
US (2) US7326729B2 (https=)
EP (1) EP1745032B1 (https=)
JP (2) JP2007537272A (https=)
KR (1) KR20070011475A (https=)
CN (1) CN1984899B (https=)
AU (1) AU2005245399A1 (https=)
CA (1) CA2565519A1 (https=)
IL (1) IL179162A0 (https=)
MX (1) MXPA06013118A (https=)
WO (1) WO2005113534A2 (https=)
ZA (1) ZA200609237B (https=)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102005008183A1 (de) * 2005-02-23 2006-08-31 Bayer Healthcare Ag Heterocyclylamid-substituierte Imidazole
PL2009992T3 (pl) * 2006-04-21 2012-11-30 Glaxosmithkline Llc Antagoniści receptora IL-8
ES2362949T3 (es) * 2006-06-08 2011-07-15 Eli Lilly And Company Carboxamidas substituidas como antagonistas del receptor metabotrópico de grupo i.
EP2066335A4 (en) * 2006-09-26 2010-01-20 Univ Case Western Reserve ZYTOKINSIGNALISIERUNG
JP2010510291A (ja) * 2006-11-23 2010-04-02 ノバルティス アーゲー CXCR2アンタゴニストとしての5−スルファニルメチル−ピラゾロ[1,5−a]ピリミジン−7−オール
RU2009123525A (ru) * 2006-11-23 2010-12-27 Новартис АГ (CH) ПРОИЗВОДНЫЕ 5-СУЛЬФАНИЛМЕТИЛ[1,2,4}ТРИАЗОЛ[1,5-а]ПИРИМИДИН-7-ОЛА В КАЧЕСТВЕ АНТАГОНИСТОВ CXCR2
KR20090115749A (ko) 2007-02-26 2009-11-05 산텐 세이야꾸 가부시키가이샤 우레이드기와 아미노카르보닐기를 치환기로서 갖는 신규 피롤 유도체
WO2009026248A2 (en) * 2007-08-17 2009-02-26 The Government Of The United States, As Represented By The Secretary Of Health And Human Services, National Institutes Of Health, Office Of Technology Transfer Hydrazide, amide, phthalimide and phthalhydrazide analogs as inhibitors of retroviral integrase
KR101039235B1 (ko) * 2007-08-29 2011-06-07 메디포스트(주) 제대혈 유래 간엽줄기세포를 포함하는 인터루킨-8 또는지알오-알파 발현 세포가 관련된 질병의 진단, 예방 또는치료용 조성물
GB2455539B (en) * 2007-12-12 2012-01-18 Cambridge Entpr Ltd Anti-inflammatory compositions and combinations
SG157299A1 (en) 2008-05-09 2009-12-29 Agency Science Tech & Res Diagnosis and treatment of kawasaki disease
KR20110093893A (ko) 2008-11-11 2011-08-18 더 리젠츠 오브 더 유니버시티 오브 미시간 항-cxcr1 조성물 및 방법
AR082886A1 (es) * 2010-09-03 2013-01-16 Forma Therapeutics Inc Compuestos y composiciones farmaceuticas que los contienen
DK2718312T3 (en) * 2011-06-13 2018-10-15 Tla Targeted Immunotherapies Ab TREATMENT OF CONDITIONS CONNECTED WITH SEPSIS
WO2013148370A1 (en) 2012-03-30 2013-10-03 Sloan-Kettering Institute For Cancer Research S100a8/a9 as a diagnostic marker and a therapeutic target
EP2906212A4 (en) * 2012-10-15 2016-06-08 Agios Pharmaceuticals Inc THERAPEUTIC COMPOUNDS AND COMPOSITIONS
US8865723B2 (en) 2012-10-25 2014-10-21 Tetra Discovery Partners Llc Selective PDE4 B inhibition and improvement in cognition in subjects with brain injury
CN110420316A (zh) 2013-06-18 2019-11-08 纽约大学 参与金黄色葡萄球菌杀白细胞素的细胞毒性的细胞因素:新型治疗靶点
EP3055289A4 (en) * 2013-10-08 2017-03-15 Temple University Of The Commonwealth System Of Higher Education Functionalized furan-2-sulfonamides exhibiting endothelial lipase inhibition
US9763992B2 (en) 2014-02-13 2017-09-19 Father Flanagan's Boys' Home Treatment of noise induced hearing loss
EP3197886B1 (en) * 2014-09-26 2023-01-04 Shifa Biomedical Corporation Anti-endothelial lipase compounds and methods of using the same in the treatment and/or prevention of cardiovascular diseases
WO2017040742A1 (en) * 2015-09-04 2017-03-09 Dow Agrosciences Llc Molecules having pesticidal utility, and intermediates, compositions, and processes, related thereto
JP7092356B2 (ja) * 2016-06-22 2022-06-28 フーダン ユニヴァーシティ ビアリール尿素誘導体またはそれらの塩、およびそれらの調製方法および使用
US20190216790A1 (en) * 2016-10-13 2019-07-18 The Regents Of The University Of California Methods for Treating Pruritis
WO2018106945A1 (en) 2016-12-07 2018-06-14 Progenity Inc. Gastrointestinal tract detection methods, devices and systems
EP3554541B1 (en) 2016-12-14 2023-06-07 Biora Therapeutics, Inc. Treatment of a disease of the gastrointestinal tract with a chemokine/chemokine receptor inhibitor
EP3883635A1 (en) 2018-11-19 2021-09-29 Progenity, Inc. Methods and devices for treating a disease with biotherapeutics
CN115666704B (zh) 2019-12-13 2025-09-26 比特比德科有限责任公司 用于将治疗剂递送至胃肠道的可摄取装置

Family Cites Families (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3529247A1 (de) * 1985-05-17 1986-11-20 Bayer Ag, 5090 Leverkusen Verwendung von thienylharnstoffen und -isoharnstoffen als leistungsfoerdernde mittel bei tieren, neue thienylharnstoffe und -isoharnstoffe und ihre herstellung
DE3785507T2 (de) * 1986-07-31 1993-07-29 Beecham Group Plc Azabicyclische verbindungen, verfahren zu ihrer herstellung und ihre pharmazeutische verwendung.
DE4412334A1 (de) * 1994-04-11 1995-10-19 Hoechst Ag Substituierte N-Heteroaroylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
US5780483A (en) * 1995-02-17 1998-07-14 Smithkline Beecham Corporation IL-8 receptor antagonists
JPH11503110A (ja) 1995-02-17 1999-03-23 スミスクライン・ビーチャム・コーポレイション Il−8受容体拮抗剤
EP0932405A4 (en) 1996-06-27 2001-10-17 Smithkline Beckman Corp IL-8 RECEPTOR ANTAGONISTS
US6271261B1 (en) 1996-06-27 2001-08-07 Smithkline Beecham Corporation IL-8 receptor antagonists
CZ425598A3 (cs) 1996-06-27 1999-08-11 Smithkline Beecham Corporation Antagonista IL-8 receptoru
EP0915653A1 (en) 1996-06-27 1999-05-19 Smithkline Beecham Corporation Il-8 receptor antagonists
EP0907362A4 (en) 1996-06-27 1999-12-01 Smithkline Beecham Corp IL-8 RECEPTOR ANTAGONISTS
EP0957907A4 (en) 1996-08-06 2001-08-16 Smithkline Beecham Corp IL-8 RECEPTOR ANTAGONISTS
JP2002513384A (ja) 1996-08-06 2002-05-08 スミスクライン・ビーチャム・コーポレイション Il―8受容体アンタゴニスト
WO1998005329A1 (en) 1996-08-06 1998-02-12 Smithkline Beecham Corporation Il-8 receptor antagonists
JP2001527519A (ja) 1996-08-15 2001-12-25 スミスクライン・ビーチャム・コーポレイション Il―8レセプターアンタゴニスト
JP2000516621A (ja) 1996-08-15 2000-12-12 スミスクライン・ビーチャム・コーポレイション Il―8レセプターアンタゴニスト
AR008290A1 (es) 1996-08-15 1999-12-29 Smithkline Beecham Corp Nuevos compuestos que contienen guanidina utiles como antagonistas de los receptores de il-8, composiciones farmaceuticas que los contienenprocedimiento para la preparacion de dichos compuestos y procedimiento para la preparacion de intermediarios.
WO1998006398A1 (en) 1996-08-15 1998-02-19 Smithkline Beecham Corporation Il-8 receptor antagonists
JP2001501918A (ja) 1996-08-21 2001-02-13 スミスクライン・ビーチャム・コーポレイション Il―8レセプターアンタゴニスト
US6300325B1 (en) 1997-01-23 2001-10-09 Smithkline Beecham Corporation IL-8 receptor antagonists
AR008331A1 (es) 1997-01-23 1999-12-29 Smithkline Beecham Corp Compuestos antagonistas de un receptor de il-8, uso de los mismos para la fabricacion de medicamentos, procedimiento para su obtencion, composicionesfarmaceuticas que los contienen
AR015425A1 (es) 1997-09-05 2001-05-02 Smithkline Beecham Corp Compuestos de benzotiazol, composicion farmaceutica que los contiene, su uso en la manufactura de un medicamento, procedimiento para su preparacion,compuestos intermediarios y procedimiento para su preparacion
AR015426A1 (es) 1997-09-05 2001-05-02 Smithkline Beecham Corp Compuestos de benzotiazol antagonistas del receptor de il-8, composicion farmaceutica que los contiene, su uso para la manufactura de un medicamento,procedimiento para su preparacion, compuestos intermediarios y procedimiento para su preparacion
DE69831013T2 (de) * 1997-12-22 2006-04-20 Bayer Pharmaceuticals Corp., West Haven Inhibierung der raf-kinase durch substituierte heterocyclische harnstoffverbindungen
EP1047424A4 (en) 1998-01-20 2002-05-22 Smithkline Beecham Corp IL-8 RECEPTOR ANTAGONISTS
US6525069B1 (en) * 1998-12-18 2003-02-25 Bristol-Myers Squibb Pharma Co. N-ureidoalkyl-piperidines as modulators of chemokine receptor activity
UY26207A1 (es) 1999-06-16 2000-12-29 Smithkline Beecham Corp Antagonistas de los receptores de la il-8.
CO5200760A1 (es) * 1999-06-16 2002-09-27 Smithkline Beecham Corp Antagonistas del receptor de la il-8 ceptor il-8
AU6230300A (en) * 1999-07-21 2001-02-13 Kadmus Pharmaceuticals, Inc. Substituted guanidines and the use thereof
EP1104759B1 (en) * 1999-12-03 2003-10-22 Pfizer Products Inc. Heteroaryl phenyl pyrazole compounds as anti-inflammatory/analgesic agents
WO2001064691A1 (en) 2000-03-01 2001-09-07 Smithkline Beecham Corporation Il-8 receptor antagonists
WO2001064165A2 (en) 2000-03-01 2001-09-07 Smithkline Beecham Corporation Il-8 receptor antagonists
CO5280089A1 (es) 2000-03-16 2003-05-30 Smithkline Beecham Corp Antagonistas del receptor il-8
UY26627A1 (es) 2000-03-24 2001-09-28 Smithkline Beecham Corp Antagonistas de receptores de il-8
JP2004516238A (ja) * 2000-06-21 2004-06-03 ブリストル−マイヤーズ・スクイブ・ファーマ・カンパニー ケモカイン受容体活性調節剤としてのn−ウレイドアルキル−ピペリジン
WO2002076926A1 (en) 2001-02-02 2002-10-03 Schering Corporation 3,4-di-substituted cyclobutene-1, 2-diones as cxc chemokine receptor antagonists
US20040106794A1 (en) * 2001-04-16 2004-06-03 Schering Corporation 3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands
US7132445B2 (en) * 2001-04-16 2006-11-07 Schering Corporation 3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands
EP1270551A1 (en) * 2001-06-26 2003-01-02 Aventis Pharma Deutschland GmbH Urea derivatives with antiproteolytic activity
AUPR738301A0 (en) * 2001-08-30 2001-09-20 Starpharma Limited Chemotherapeutic agents
JP2005505595A (ja) * 2001-10-12 2005-02-24 シェーリング コーポレイション Cxc−ケモカインレセプターアンタゴニストとしての3,4−二置換マレイミド化合物
US6878709B2 (en) * 2002-01-04 2005-04-12 Schering Corporation 3,4-di-substituted pyridazinediones as CXC chemokine receptor antagonists
WO2003080053A1 (en) * 2002-03-18 2003-10-02 Schering Corporation Combination treatments for chemokine-mediated diseases
EP1402888A1 (en) * 2002-09-18 2004-03-31 Jerini AG The use of substituted carbocyclic compounds as rotamases inhibitors
PE20040570A1 (es) * 2002-10-09 2004-08-30 Pharmacopeia Drug Discovery Tiadiazoldioxidos y tiadiazoloxidos como ligandos del receptor de cxc- y cc-quimiocina
ES2308299T3 (es) 2003-12-19 2008-12-01 Schering Corp Tiadiazoles como ligandos de receptores de cxc-y cc-quimioquinas.
TW200530231A (en) 2003-12-22 2005-09-16 Schering Corp Isothiazole dioxides as CXC-and CC-chemokine receptor ligands
EP1912971A2 (en) * 2005-06-29 2008-04-23 Shering Corporation Di-substituted oxadiazoles as cxc-chemokine receptor ligands
MX2008000367A (es) * 2005-06-29 2008-03-07 Schering Corp Oxidiazolopirazinas y tiadiazolopirazinas 5,6-di-sustituidas como ligandos de receptor de quimiocina en la que dos cisternas son separadas por un solo aminoacido.

Similar Documents

Publication Publication Date Title
JP2007537272A5 (https=)
CN100496493C (zh) 2-氨基-4,5-三取代噻唑基衍生物
JP6475252B2 (ja) ヘテロアリール置換のニコチンアミド化合物
CA2479126A1 (en) Combination treatments for chemokine-mediated diseases
AU2010333804B2 (en) Fused heteroaromatic pyrrolidinones as syk inhibitors
CA2960446C (en) N-pyridinyl acetamide derivatives as inhibitors of the wnt signalling pathway
JP2004536796A5 (https=)
DK2225238T3 (en) Derivatives of 6,7-dihydro-5H-imidazoý1,2- imidazol-3-carboxylic acid amides.
WO2006019962B1 (en) Compositions and methods for treatment of colitis
KR20200101400A (ko) 아릴 및 헤테로아릴 치환된 인돌 화합물
TW200418861A (en) Pyrrolopyridazine derivatives
JP2007514746A5 (https=)
CA2687766C (en) Azaindazole compounds and methods of use
US20090069288A1 (en) Novel therapeutic compounds
RU2008141368A (ru) Новые гетероциклические соединения замещенного пиридина с антагонистической активностью схсr3
JPH07267959A (ja) イミダゾピリダジン誘導体
JP2010525057A5 (https=)
KR20090106604A (ko) 축합 피리딘 화합물
BRPI0720043A2 (pt) Composto oxadiazol
AU2010332955B8 (en) 3,4,4a,10b-tetrahydro-1H-thiopyrano-[4, 3-c] isoquinoline derivatives
JP7106528B2 (ja) Trpv4拮抗薬
JP6039067B2 (ja) 抗ウイルス剤としてのトリアゾール化合物
JP2007515489A5 (https=)
WO2014194741A1 (zh) 一种jak激酶抑制剂的硫酸氢盐及其制备方法
JP6101250B2 (ja) 治療薬としてのイソオキサゾリン類