ZA200609237B - CXCR1 and CXCR2 chemokine antagonists - Google Patents
CXCR1 and CXCR2 chemokine antagonistsInfo
- Publication number
- ZA200609237B ZA200609237B ZA200609237A ZA200609237A ZA200609237B ZA 200609237 B ZA200609237 B ZA 200609237B ZA 200609237 A ZA200609237 A ZA 200609237A ZA 200609237 A ZA200609237 A ZA 200609237A ZA 200609237 B ZA200609237 B ZA 200609237B
- Authority
- ZA
- South Africa
- Prior art keywords
- cxcr1
- chemokine antagonists
- cxcr2 chemokine
- cxcr2
- antagonists
- Prior art date
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- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/36—Nitrogen atoms
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| EP (1) | EP1745032B1 (https=) |
| JP (2) | JP2007537272A (https=) |
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| IL (1) | IL179162A0 (https=) |
| MX (1) | MXPA06013118A (https=) |
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| ZA (1) | ZA200609237B (https=) |
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| DE102005008183A1 (de) * | 2005-02-23 | 2006-08-31 | Bayer Healthcare Ag | Heterocyclylamid-substituierte Imidazole |
| AR060562A1 (es) * | 2006-04-21 | 2008-06-25 | Smithkline Beecham Corp | Compuestos heterociclicos como antagonistas del receptor il-8. procesos de obtencion y composiciones farmaceuticas. |
| UA95480C2 (uk) * | 2006-06-08 | 2011-08-10 | Елі Ліллі Енд Компані | Заміщені карбоксаміди |
| WO2008039876A1 (en) * | 2006-09-26 | 2008-04-03 | Case Western Reserve University | Cytokine signaling |
| DE602007009865D1 (de) * | 2006-11-23 | 2010-11-25 | Novartis Ag | 5-sulfanylmethylä1,2,4ütriazolä1,5-aüpyrimidin-7-olderivate als cxcr2-antagonisten |
| CA2669579A1 (en) * | 2006-11-23 | 2008-05-29 | Novartis Ag | 5-sulfanylmethyl-pyrazolo [1,5-a] pyrimidin-7-ol derivatives as cxcr2 antagonists |
| KR20090115749A (ko) | 2007-02-26 | 2009-11-05 | 산텐 세이야꾸 가부시키가이샤 | 우레이드기와 아미노카르보닐기를 치환기로서 갖는 신규 피롤 유도체 |
| WO2009026248A2 (en) * | 2007-08-17 | 2009-02-26 | The Government Of The United States, As Represented By The Secretary Of Health And Human Services, National Institutes Of Health, Office Of Technology Transfer | Hydrazide, amide, phthalimide and phthalhydrazide analogs as inhibitors of retroviral integrase |
| KR101039235B1 (ko) * | 2007-08-29 | 2011-06-07 | 메디포스트(주) | 제대혈 유래 간엽줄기세포를 포함하는 인터루킨-8 또는지알오-알파 발현 세포가 관련된 질병의 진단, 예방 또는치료용 조성물 |
| GB2455539B (en) * | 2007-12-12 | 2012-01-18 | Cambridge Entpr Ltd | Anti-inflammatory compositions and combinations |
| JP2010043063A (ja) * | 2008-05-09 | 2010-02-25 | Agency For Science Technology & Research | 川崎病の診断及び治療 |
| PT2356462T (pt) | 2008-11-11 | 2017-04-07 | Univ Michigan Regents | Composições e métodos anti-cxcr1 |
| CN106243023A (zh) * | 2010-09-03 | 2016-12-21 | 福马Tm有限责任公司 | 用于抑制nampt的胍化合物和组合物 |
| ES2688081T3 (es) * | 2011-06-13 | 2018-10-30 | Tla Targeted Immunotherapies Ab | Tratamiento de dolencias asociadas a septicemia |
| AU2013240224A1 (en) | 2012-03-30 | 2014-10-16 | Sloan-Kettering Institute For Cancer Research | S100A8/A9 as a diagnostic marker and a therapeutic target |
| WO2014062511A1 (en) * | 2012-10-15 | 2014-04-24 | Agios Pharmaceuticals, Inc. | Therapeutic compounds and compositions |
| US8865723B2 (en) | 2012-10-25 | 2014-10-21 | Tetra Discovery Partners Llc | Selective PDE4 B inhibition and improvement in cognition in subjects with brain injury |
| WO2014205127A2 (en) | 2013-06-18 | 2014-12-24 | New York University | Cellular factors involved in the cytotoxicity of staphylococcus aureus leukocidins: novel therapeutic targets |
| WO2015054117A1 (en) * | 2013-10-08 | 2015-04-16 | Temple University-Of The Commonwealth System Of Higher Education | Functionalized furan-2-sulfonamides exhibiting endothelial lipase inhibition |
| US9763992B2 (en) | 2014-02-13 | 2017-09-19 | Father Flanagan's Boys' Home | Treatment of noise induced hearing loss |
| JP6667187B2 (ja) | 2014-09-26 | 2020-03-18 | シファ バイオメディカル コーポレーション | 抗内皮リパーゼ化合物並びに心血管疾患の治療および/または予防におけるその使用方法 |
| WO2017040742A1 (en) * | 2015-09-04 | 2017-03-09 | Dow Agrosciences Llc | Molecules having pesticidal utility, and intermediates, compositions, and processes, related thereto |
| JP7092356B2 (ja) * | 2016-06-22 | 2022-06-28 | フーダン ユニヴァーシティ | ビアリール尿素誘導体またはそれらの塩、およびそれらの調製方法および使用 |
| WO2018071687A1 (en) * | 2016-10-13 | 2018-04-19 | The Regents Of The University Of California | Methods of treating pruritis |
| US10610104B2 (en) | 2016-12-07 | 2020-04-07 | Progenity, Inc. | Gastrointestinal tract detection methods, devices and systems |
| CA3045310A1 (en) | 2016-12-14 | 2018-06-21 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with a chemokine/chemokine receptor inhibitor |
| US20220249814A1 (en) | 2018-11-19 | 2022-08-11 | Progenity, Inc. | Methods and devices for treating a disease with biotherapeutics |
| CN121197633A (zh) | 2019-12-13 | 2025-12-26 | 比特比德科有限责任公司 | 用于将治疗剂递送至胃肠道的可摄取装置 |
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| DE3529247A1 (de) * | 1985-05-17 | 1986-11-20 | Bayer Ag, 5090 Leverkusen | Verwendung von thienylharnstoffen und -isoharnstoffen als leistungsfoerdernde mittel bei tieren, neue thienylharnstoffe und -isoharnstoffe und ihre herstellung |
| EP0255297B1 (en) | 1986-07-31 | 1993-04-21 | Beecham Group Plc | Azabicyclic compounds, process for their preparation, and their pharmaceutical use |
| DE4412334A1 (de) * | 1994-04-11 | 1995-10-19 | Hoechst Ag | Substituierte N-Heteroaroylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
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| WO1997049399A1 (en) | 1996-06-27 | 1997-12-31 | Smithkline Beecham Corporation | Il-8 receptor antagonists |
| EP0932405A4 (en) | 1996-06-27 | 2001-10-17 | Smithkline Beckman Corp | IL-8 RECEPTOR ANTAGONISTS |
| JP2000514049A (ja) | 1996-06-27 | 2000-10-24 | スミスクライン・ビーチャム・コーポレイション | Il―8受容体拮抗薬 |
| CZ425698A3 (cs) | 1996-06-27 | 1999-06-16 | Smithkline Beecham Corporation | Antagonista IL-8 receptoru |
| JP2000515495A (ja) | 1996-06-27 | 2000-11-21 | スミスクライン・ビーチャム・コーポレイション | Il―8レセプターアンタゴニスト |
| WO1998005328A1 (en) | 1996-08-06 | 1998-02-12 | Smithkline Beecham Corporation | Il-8 receptor antagonists |
| EP0934066A4 (en) | 1996-08-06 | 2001-10-17 | Smithkline Beecham Corp | IL-8 RECEPTOR ANTAGONISTS |
| US6248785B1 (en) | 1996-08-06 | 2001-06-19 | Smithkline Beecham Corporation | IL-8 receptor antagonists |
| JP2000516620A (ja) | 1996-08-15 | 2000-12-12 | スミスクライン・ビーチャム・コーポレイション | Il―8レセプターアンタゴニスト |
| AR008290A1 (es) | 1996-08-15 | 1999-12-29 | Smithkline Beecham Corp | Nuevos compuestos que contienen guanidina utiles como antagonistas de los receptores de il-8, composiciones farmaceuticas que los contienenprocedimiento para la preparacion de dichos compuestos y procedimiento para la preparacion de intermediarios. |
| JP2001527519A (ja) | 1996-08-15 | 2001-12-25 | スミスクライン・ビーチャム・コーポレイション | Il―8レセプターアンタゴニスト |
| US6335352B1 (en) | 1996-08-15 | 2002-01-01 | Smithkline Beecham Corporation | IL-8 receptor antagonists |
| EP1019035A4 (en) | 1996-08-21 | 2001-10-17 | Smithkline Beecham Corp | IL-8 RECEPTOR ANTAGONISTS |
| AR008331A1 (es) | 1997-01-23 | 1999-12-29 | Smithkline Beecham Corp | Compuestos antagonistas de un receptor de il-8, uso de los mismos para la fabricacion de medicamentos, procedimiento para su obtencion, composicionesfarmaceuticas que los contienen |
| BR9807083A (pt) | 1997-01-23 | 2000-04-18 | Smithkline Beckman Corp | Antagonistas ao receptor de il-8 |
| AR015425A1 (es) | 1997-09-05 | 2001-05-02 | Smithkline Beecham Corp | Compuestos de benzotiazol, composicion farmaceutica que los contiene, su uso en la manufactura de un medicamento, procedimiento para su preparacion,compuestos intermediarios y procedimiento para su preparacion |
| AR015426A1 (es) | 1997-09-05 | 2001-05-02 | Smithkline Beecham Corp | Compuestos de benzotiazol antagonistas del receptor de il-8, composicion farmaceutica que los contiene, su uso para la manufactura de un medicamento,procedimiento para su preparacion, compuestos intermediarios y procedimiento para su preparacion |
| SK286213B6 (sk) * | 1997-12-22 | 2008-05-06 | Bayer Corporation | Substituované heterocyklické močoviny, farmaceutický prípravok ich obsahujúci a ich použitie |
| JP2002509106A (ja) | 1998-01-20 | 2002-03-26 | スミスクライン・ビーチャム・コーポレイション | Il−8受容体アンタゴニスト |
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| CO5200760A1 (es) * | 1999-06-16 | 2002-09-27 | Smithkline Beecham Corp | Antagonistas del receptor de la il-8 ceptor il-8 |
| AU6230300A (en) * | 1999-07-21 | 2001-02-13 | Kadmus Pharmaceuticals, Inc. | Substituted guanidines and the use thereof |
| DE60006057T2 (de) | 1999-12-03 | 2004-05-27 | Pfizer Products Inc., Groton | Heteroarylphenylpyrazolverbindungen zur Verwendung als analgetisches/entzündungshemmendes Mittel |
| AU2001241896A1 (en) | 2000-03-01 | 2001-09-12 | Smith Kline Beecham Corporation | Il-8 receptor antagonists |
| EP1265905A4 (en) | 2000-03-01 | 2003-03-12 | Smithkline Beecham Corp | IL-2 RECEPTOR ANTAGONISTS |
| AR031098A1 (es) | 2000-03-16 | 2003-09-10 | Smithkline Beecham Corp | Compuestos de hidroxifenil urea sustituidos con sulfonamidas, composiciones farmaceuticas que los comprenden, y uso de los mismos en la fabricacion de medicamentos para tratar una enfermedad mediada por una quimioquina |
| UY26627A1 (es) | 2000-03-24 | 2001-09-28 | Smithkline Beecham Corp | Antagonistas de receptores de il-8 |
| EP1294690A2 (en) * | 2000-06-21 | 2003-03-26 | Bristol-Myers Squibb Pharma Company | N-ureidoalkyl-piperidines as modulators of chemokine receptor activity |
| RU2003126913A (ru) | 2001-02-02 | 2005-03-10 | Шеринг Корпорейшн (US) | 3,4-дизамещенные циклобутен-1,2-дионы, как антагонисты хемокинового рецептора схс |
| US7132445B2 (en) | 2001-04-16 | 2006-11-07 | Schering Corporation | 3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands |
| US20040106794A1 (en) * | 2001-04-16 | 2004-06-03 | Schering Corporation | 3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands |
| EP1270551A1 (en) * | 2001-06-26 | 2003-01-02 | Aventis Pharma Deutschland GmbH | Urea derivatives with antiproteolytic activity |
| AUPR738301A0 (en) * | 2001-08-30 | 2001-09-20 | Starpharma Limited | Chemotherapeutic agents |
| JP2005505595A (ja) | 2001-10-12 | 2005-02-24 | シェーリング コーポレイション | Cxc−ケモカインレセプターアンタゴニストとしての3,4−二置換マレイミド化合物 |
| US6878709B2 (en) | 2002-01-04 | 2005-04-12 | Schering Corporation | 3,4-di-substituted pyridazinediones as CXC chemokine receptor antagonists |
| US20040053953A1 (en) * | 2002-03-18 | 2004-03-18 | Schering Corporation | Treatment of chemokine mediated diseases |
| EP1402888A1 (en) * | 2002-09-18 | 2004-03-31 | Jerini AG | The use of substituted carbocyclic compounds as rotamases inhibitors |
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| MXPA06007076A (es) | 2003-12-19 | 2006-08-31 | Pharmacopeia Drug Discovery | Tiadiazoles como ligandos del receptor cxc y cc-quimiocina. |
| CA2550540A1 (en) * | 2003-12-22 | 2005-07-28 | Schering Corporation | Isothiazole dioxides as cxc- and cc- chemokine receptor ligands |
| MX2008000366A (es) * | 2005-06-29 | 2008-03-07 | Schering Corp | Oxadiazoles di-sustituidos como ligandos del receptor cxc-quimiocina. |
| JP2009500328A (ja) * | 2005-06-29 | 2009-01-08 | シェーリング コーポレイション | Cxc−ケモカインレセプターリガンドとしての5,6−ジ−置換オキサジアゾロピラジンおよびチアジアゾロピラジン |
-
2005
- 2005-05-11 WO PCT/US2005/016507 patent/WO2005113534A2/en not_active Ceased
- 2005-05-11 JP JP2007513317A patent/JP2007537272A/ja not_active Ceased
- 2005-05-11 CA CA002565519A patent/CA2565519A1/en not_active Abandoned
- 2005-05-11 KR KR1020067023571A patent/KR20070011475A/ko not_active Withdrawn
- 2005-05-11 AU AU2005245399A patent/AU2005245399A1/en not_active Abandoned
- 2005-05-11 US US11/126,977 patent/US7326729B2/en not_active Expired - Fee Related
- 2005-05-11 EP EP05779979.3A patent/EP1745032B1/en not_active Expired - Lifetime
- 2005-05-11 MX MXPA06013118A patent/MXPA06013118A/es active IP Right Grant
- 2005-05-11 CN CN2005800232328A patent/CN1984899B/zh not_active Expired - Fee Related
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2006
- 2006-11-06 ZA ZA200609237A patent/ZA200609237B/xx unknown
- 2006-11-09 IL IL179162A patent/IL179162A0/en unknown
-
2007
- 2007-07-10 US US11/775,567 patent/US20070248594A1/en not_active Abandoned
-
2011
- 2011-10-11 JP JP2011224353A patent/JP2012006982A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| CA2565519A1 (en) | 2005-12-01 |
| KR20070011475A (ko) | 2007-01-24 |
| CN1984899B (zh) | 2011-07-27 |
| CN1984899A (zh) | 2007-06-20 |
| AU2005245399A1 (en) | 2005-12-01 |
| WO2005113534A3 (en) | 2006-10-26 |
| US20060014794A1 (en) | 2006-01-19 |
| US7326729B2 (en) | 2008-02-05 |
| EP1745032A2 (en) | 2007-01-24 |
| JP2007537272A (ja) | 2007-12-20 |
| US20070248594A1 (en) | 2007-10-25 |
| WO2005113534A2 (en) | 2005-12-01 |
| MXPA06013118A (es) | 2007-02-28 |
| JP2012006982A (ja) | 2012-01-12 |
| EP1745032B1 (en) | 2013-07-31 |
| IL179162A0 (en) | 2007-03-08 |
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