JP2007537272A - Ｃｘｃｒ１およびｃｘｃｒ２ケモカインアンタゴニスト - Google Patents

Ｃｘｃｒ１およびｃｘｃｒ２ケモカインアンタゴニスト Download PDF

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JP2007537272A
JP2007537272A JP2007513317A JP2007513317A JP2007537272A JP 2007537272 A JP2007537272 A JP 2007537272A JP 2007513317 A JP2007513317 A JP 2007513317A JP 2007513317 A JP2007513317 A JP 2007513317A JP 2007537272 A JP2007537272 A JP 2007537272A
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JP2007537272A5 (https=
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ジァンファ チャオ，
アーサー ジー． タベラス，
シンシア ジェイ． アキ，
ダニエル ルンデル，
ジェイ ファイン，
トニー プリーストリー，
アンジェロ レッジャーニ，
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Merck Sharp and Dohme LLC
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Schering Corp
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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013536870A (ja) * 2010-09-03 2013-09-26 フォーマ ティーエム， エルエルシー． Ｎａｍｐｔの阻害のための新規化合物及び組成物
JP2015536306A (ja) * 2012-10-15 2015-12-21 アジオス ファーマシューティカルズ， インコーポレイテッド 治療化合物および組成物
JP2019520359A (ja) * 2016-06-22 2019-07-18 フーダン ユニヴァーシティＦｕｄａｎ Ｕｎｉｖｅｒｓｉｔｙ ビアリール尿素誘導体またはそれらの塩、およびそれらの調製方法および使用

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102005008183A1 (de) * 2005-02-23 2006-08-31 Bayer Healthcare Ag Heterocyclylamid-substituierte Imidazole
PL2009992T3 (pl) * 2006-04-21 2012-11-30 Glaxosmithkline Llc Antagoniści receptora IL-8
ES2362949T3 (es) * 2006-06-08 2011-07-15 Eli Lilly And Company Carboxamidas substituidas como antagonistas del receptor metabotrópico de grupo i.
EP2066335A4 (en) * 2006-09-26 2010-01-20 Univ Case Western Reserve ZYTOKINSIGNALISIERUNG
JP2010510291A (ja) * 2006-11-23 2010-04-02 ノバルティス アーゲー ＣＸＣＲ２アンタゴニストとしての５−スルファニルメチル−ピラゾロ［１，５−ａ］ピリミジン−７−オール
RU2009123525A (ru) * 2006-11-23 2010-12-27 Новартис АГ (CH) ПРОИЗВОДНЫЕ 5-СУЛЬФАНИЛМЕТИЛ[1,2,4}ТРИАЗОЛ[1,5-а]ПИРИМИДИН-7-ОЛА В КАЧЕСТВЕ АНТАГОНИСТОВ CXCR2
KR20090115749A (ko) 2007-02-26 2009-11-05 산텐 세이야꾸 가부시키가이샤 우레이드기와 아미노카르보닐기를 치환기로서 갖는 신규 피롤 유도체
WO2009026248A2 (en) * 2007-08-17 2009-02-26 The Government Of The United States, As Represented By The Secretary Of Health And Human Services, National Institutes Of Health, Office Of Technology Transfer Hydrazide, amide, phthalimide and phthalhydrazide analogs as inhibitors of retroviral integrase
KR101039235B1 (ko) * 2007-08-29 2011-06-07 메디포스트(주) 제대혈 유래 간엽줄기세포를 포함하는 인터루킨-8 또는지알오-알파 발현 세포가 관련된 질병의 진단, 예방 또는치료용 조성물
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DK2718312T3 (en) * 2011-06-13 2018-10-15 Tla Targeted Immunotherapies Ab TREATMENT OF CONDITIONS CONNECTED WITH SEPSIS
WO2013148370A1 (en) 2012-03-30 2013-10-03 Sloan-Kettering Institute For Cancer Research S100a8/a9 as a diagnostic marker and a therapeutic target
US8865723B2 (en) 2012-10-25 2014-10-21 Tetra Discovery Partners Llc Selective PDE4 B inhibition and improvement in cognition in subjects with brain injury
CN110420316A (zh) 2013-06-18 2019-11-08 纽约大学 参与金黄色葡萄球菌杀白细胞素的细胞毒性的细胞因素：新型治疗靶点
EP3055289A4 (en) * 2013-10-08 2017-03-15 Temple University Of The Commonwealth System Of Higher Education Functionalized furan-2-sulfonamides exhibiting endothelial lipase inhibition
US9763992B2 (en) 2014-02-13 2017-09-19 Father Flanagan's Boys' Home Treatment of noise induced hearing loss
EP3197886B1 (en) * 2014-09-26 2023-01-04 Shifa Biomedical Corporation Anti-endothelial lipase compounds and methods of using the same in the treatment and/or prevention of cardiovascular diseases
WO2017040742A1 (en) * 2015-09-04 2017-03-09 Dow Agrosciences Llc Molecules having pesticidal utility, and intermediates, compositions, and processes, related thereto
US20190216790A1 (en) * 2016-10-13 2019-07-18 The Regents Of The University Of California Methods for Treating Pruritis
WO2018106945A1 (en) 2016-12-07 2018-06-14 Progenity Inc. Gastrointestinal tract detection methods, devices and systems
EP3554541B1 (en) 2016-12-14 2023-06-07 Biora Therapeutics, Inc. Treatment of a disease of the gastrointestinal tract with a chemokine/chemokine receptor inhibitor
EP3883635A1 (en) 2018-11-19 2021-09-29 Progenity, Inc. Methods and devices for treating a disease with biotherapeutics
CN115666704B (zh) 2019-12-13 2025-09-26 比特比德科有限责任公司 用于将治疗剂递送至胃肠道的可摄取装置

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07291927A (ja) * 1994-04-11 1995-11-07 Hoechst Ag 置換されたｎ−ヘテロアロイルグアニジン、それらの製造法、薬剤または診断剤としてのそれらの使用およびそれらを含有する薬剤
JP2000504722A (ja) * 1995-02-17 2000-04-18 スミスクライン・ビーチャム・コーポレイション Ｉｌ―８レセプターアンタゴニスト
JP2001526220A (ja) * 1997-12-22 2001-12-18 バイエル コーポレイション 置換複素環式尿素を用いたｒａｆキナーゼの阻害
WO2003002524A2 (en) * 2001-06-26 2003-01-09 Aventis Pharma Deutschland Gmbh Urea derivatives with antiproteolytic activity
JP2003501459A (ja) * 1999-06-16 2003-01-14 スミスクライン・ビーチャム・コーポレイション Ｉｌ−８受容体アンタゴニスト
WO2003018536A1 (en) * 2001-08-30 2003-03-06 Starpharma Limited Chemotherapeutic agents
JP2003525213A (ja) * 1999-07-21 2003-08-26 キャドマス ファーマシューティカルズ， インコーポレイテッド 置換されたグアニジンおよびその使用
WO2004026815A2 (en) * 2002-09-18 2004-04-01 Jerini Ag Phenol derivatives and their use as rotamase inhibitors

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3529247A1 (de) * 1985-05-17 1986-11-20 Bayer Ag, 5090 Leverkusen Verwendung von thienylharnstoffen und -isoharnstoffen als leistungsfoerdernde mittel bei tieren, neue thienylharnstoffe und -isoharnstoffe und ihre herstellung
DE3785507T2 (de) * 1986-07-31 1993-07-29 Beecham Group Plc Azabicyclische verbindungen, verfahren zu ihrer herstellung und ihre pharmazeutische verwendung.
US5780483A (en) * 1995-02-17 1998-07-14 Smithkline Beecham Corporation IL-8 receptor antagonists
EP0932405A4 (en) 1996-06-27 2001-10-17 Smithkline Beckman Corp IL-8 RECEPTOR ANTAGONISTS
US6271261B1 (en) 1996-06-27 2001-08-07 Smithkline Beecham Corporation IL-8 receptor antagonists
CZ425598A3 (cs) 1996-06-27 1999-08-11 Smithkline Beecham Corporation Antagonista IL-8 receptoru
EP0915653A1 (en) 1996-06-27 1999-05-19 Smithkline Beecham Corporation Il-8 receptor antagonists
EP0907362A4 (en) 1996-06-27 1999-12-01 Smithkline Beecham Corp IL-8 RECEPTOR ANTAGONISTS
EP0957907A4 (en) 1996-08-06 2001-08-16 Smithkline Beecham Corp IL-8 RECEPTOR ANTAGONISTS
JP2002513384A (ja) 1996-08-06 2002-05-08 スミスクライン・ビーチャム・コーポレイション Ｉｌ―８受容体アンタゴニスト
WO1998005329A1 (en) 1996-08-06 1998-02-12 Smithkline Beecham Corporation Il-8 receptor antagonists
JP2001527519A (ja) 1996-08-15 2001-12-25 スミスクライン・ビーチャム・コーポレイション Ｉｌ―８レセプターアンタゴニスト
JP2000516621A (ja) 1996-08-15 2000-12-12 スミスクライン・ビーチャム・コーポレイション Ｉｌ―８レセプターアンタゴニスト
AR008290A1 (es) 1996-08-15 1999-12-29 Smithkline Beecham Corp Nuevos compuestos que contienen guanidina utiles como antagonistas de los receptores de il-8, composiciones farmaceuticas que los contienenprocedimiento para la preparacion de dichos compuestos y procedimiento para la preparacion de intermediarios.
WO1998006398A1 (en) 1996-08-15 1998-02-19 Smithkline Beecham Corporation Il-8 receptor antagonists
JP2001501918A (ja) 1996-08-21 2001-02-13 スミスクライン・ビーチャム・コーポレイション Ｉｌ―８レセプターアンタゴニスト
US6300325B1 (en) 1997-01-23 2001-10-09 Smithkline Beecham Corporation IL-8 receptor antagonists
AR008331A1 (es) 1997-01-23 1999-12-29 Smithkline Beecham Corp Compuestos antagonistas de un receptor de il-8, uso de los mismos para la fabricacion de medicamentos, procedimiento para su obtencion, composicionesfarmaceuticas que los contienen
AR015425A1 (es) 1997-09-05 2001-05-02 Smithkline Beecham Corp Compuestos de benzotiazol, composicion farmaceutica que los contiene, su uso en la manufactura de un medicamento, procedimiento para su preparacion,compuestos intermediarios y procedimiento para su preparacion
AR015426A1 (es) 1997-09-05 2001-05-02 Smithkline Beecham Corp Compuestos de benzotiazol antagonistas del receptor de il-8, composicion farmaceutica que los contiene, su uso para la manufactura de un medicamento,procedimiento para su preparacion, compuestos intermediarios y procedimiento para su preparacion
EP1047424A4 (en) 1998-01-20 2002-05-22 Smithkline Beecham Corp IL-8 RECEPTOR ANTAGONISTS
US6525069B1 (en) * 1998-12-18 2003-02-25 Bristol-Myers Squibb Pharma Co. N-ureidoalkyl-piperidines as modulators of chemokine receptor activity
UY26207A1 (es) 1999-06-16 2000-12-29 Smithkline Beecham Corp Antagonistas de los receptores de la il-8.
EP1104759B1 (en) * 1999-12-03 2003-10-22 Pfizer Products Inc. Heteroaryl phenyl pyrazole compounds as anti-inflammatory/analgesic agents
WO2001064691A1 (en) 2000-03-01 2001-09-07 Smithkline Beecham Corporation Il-8 receptor antagonists
WO2001064165A2 (en) 2000-03-01 2001-09-07 Smithkline Beecham Corporation Il-8 receptor antagonists
CO5280089A1 (es) 2000-03-16 2003-05-30 Smithkline Beecham Corp Antagonistas del receptor il-8
UY26627A1 (es) 2000-03-24 2001-09-28 Smithkline Beecham Corp Antagonistas de receptores de il-8
JP2004516238A (ja) * 2000-06-21 2004-06-03 ブリストル−マイヤーズ・スクイブ・ファーマ・カンパニー ケモカイン受容体活性調節剤としてのｎ−ウレイドアルキル−ピペリジン
WO2002076926A1 (en) 2001-02-02 2002-10-03 Schering Corporation 3,4-di-substituted cyclobutene-1, 2-diones as cxc chemokine receptor antagonists
US20040106794A1 (en) * 2001-04-16 2004-06-03 Schering Corporation 3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands
US7132445B2 (en) * 2001-04-16 2006-11-07 Schering Corporation 3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands
JP2005505595A (ja) * 2001-10-12 2005-02-24 シェーリング　コーポレイション Ｃｘｃ−ケモカインレセプターアンタゴニストとしての３，４−二置換マレイミド化合物
US6878709B2 (en) * 2002-01-04 2005-04-12 Schering Corporation 3,4-di-substituted pyridazinediones as CXC chemokine receptor antagonists
WO2003080053A1 (en) * 2002-03-18 2003-10-02 Schering Corporation Combination treatments for chemokine-mediated diseases
PE20040570A1 (es) * 2002-10-09 2004-08-30 Pharmacopeia Drug Discovery Tiadiazoldioxidos y tiadiazoloxidos como ligandos del receptor de cxc- y cc-quimiocina
ES2308299T3 (es) 2003-12-19 2008-12-01 Schering Corp Tiadiazoles como ligandos de receptores de cxc-y cc-quimioquinas.
TW200530231A (en) 2003-12-22 2005-09-16 Schering Corp Isothiazole dioxides as CXC-and CC-chemokine receptor ligands
EP1912971A2 (en) * 2005-06-29 2008-04-23 Shering Corporation Di-substituted oxadiazoles as cxc-chemokine receptor ligands
MX2008000367A (es) * 2005-06-29 2008-03-07 Schering Corp Oxidiazolopirazinas y tiadiazolopirazinas 5,6-di-sustituidas como ligandos de receptor de quimiocina en la que dos cisternas son separadas por un solo aminoacido.

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07291927A (ja) * 1994-04-11 1995-11-07 Hoechst Ag 置換されたｎ−ヘテロアロイルグアニジン、それらの製造法、薬剤または診断剤としてのそれらの使用およびそれらを含有する薬剤
JP2000504722A (ja) * 1995-02-17 2000-04-18 スミスクライン・ビーチャム・コーポレイション Ｉｌ―８レセプターアンタゴニスト
JP2001526220A (ja) * 1997-12-22 2001-12-18 バイエル コーポレイション 置換複素環式尿素を用いたｒａｆキナーゼの阻害
JP2003501459A (ja) * 1999-06-16 2003-01-14 スミスクライン・ビーチャム・コーポレイション Ｉｌ−８受容体アンタゴニスト
JP2003525213A (ja) * 1999-07-21 2003-08-26 キャドマス ファーマシューティカルズ， インコーポレイテッド 置換されたグアニジンおよびその使用
WO2003002524A2 (en) * 2001-06-26 2003-01-09 Aventis Pharma Deutschland Gmbh Urea derivatives with antiproteolytic activity
WO2003018536A1 (en) * 2001-08-30 2003-03-06 Starpharma Limited Chemotherapeutic agents
WO2004026815A2 (en) * 2002-09-18 2004-04-01 Jerini Ag Phenol derivatives and their use as rotamase inhibitors

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013536870A (ja) * 2010-09-03 2013-09-26 フォーマ ティーエム， エルエルシー． Ｎａｍｐｔの阻害のための新規化合物及び組成物
JP2015536306A (ja) * 2012-10-15 2015-12-21 アジオス ファーマシューティカルズ， インコーポレイテッド 治療化合物および組成物
JP2019520359A (ja) * 2016-06-22 2019-07-18 フーダン ユニヴァーシティＦｕｄａｎ Ｕｎｉｖｅｒｓｉｔｙ ビアリール尿素誘導体またはそれらの塩、およびそれらの調製方法および使用
JP7092356B2 (ja) 2016-06-22 2022-06-28 フーダン ユニヴァーシティ ビアリール尿素誘導体またはそれらの塩、およびそれらの調製方法および使用

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