JP2007044044A5 - - Google Patents
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- JP2007044044A5 JP2007044044A5 JP2006220748A JP2006220748A JP2007044044A5 JP 2007044044 A5 JP2007044044 A5 JP 2007044044A5 JP 2006220748 A JP2006220748 A JP 2006220748A JP 2006220748 A JP2006220748 A JP 2006220748A JP 2007044044 A5 JP2007044044 A5 JP 2007044044A5
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- Prior art keywords
- polypeptide
- liver
- seq
- amino acid
- pancreas
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108090000765 processed proteins & peptides Proteins 0.000 claims 74
- 229920001184 polypeptide Polymers 0.000 claims 72
- 102000004196 processed proteins & peptides Human genes 0.000 claims 72
- 210000004185 liver Anatomy 0.000 claims 46
- 125000003275 alpha amino acid group Chemical group 0.000 claims 33
- 239000002773 nucleotide Substances 0.000 claims 31
- 125000003729 nucleotide group Chemical group 0.000 claims 31
- 210000000496 pancreas Anatomy 0.000 claims 30
- 210000004027 cell Anatomy 0.000 claims 26
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 20
- 238000000034 method Methods 0.000 claims 19
- 102000039446 nucleic acids Human genes 0.000 claims 16
- 108020004707 nucleic acids Proteins 0.000 claims 16
- 150000007523 nucleic acids Chemical class 0.000 claims 16
- 108091008794 FGF receptors Proteins 0.000 claims 15
- 102000044168 Fibroblast Growth Factor Receptor Human genes 0.000 claims 15
- 230000035605 chemotaxis Effects 0.000 claims 15
- 230000028327 secretion Effects 0.000 claims 15
- 230000000381 tumorigenic effect Effects 0.000 claims 15
- 230000024245 cell differentiation Effects 0.000 claims 13
- 230000010261 cell growth Effects 0.000 claims 11
- 150000001413 amino acids Chemical class 0.000 claims 9
- 150000001875 compounds Chemical class 0.000 claims 8
- 239000012634 fragment Substances 0.000 claims 8
- 230000008569 process Effects 0.000 claims 7
- 230000000295 complement effect Effects 0.000 claims 6
- 230000000694 effects Effects 0.000 claims 6
- 238000004519 manufacturing process Methods 0.000 claims 5
- 239000000203 mixture Substances 0.000 claims 5
- 238000012217 deletion Methods 0.000 claims 4
- 230000037430 deletion Effects 0.000 claims 4
- 238000003780 insertion Methods 0.000 claims 4
- 230000037431 insertion Effects 0.000 claims 4
- 230000001575 pathological effect Effects 0.000 claims 4
- 238000004904 shortening Methods 0.000 claims 4
- 238000006467 substitution reaction Methods 0.000 claims 4
- 241001465754 Metazoa Species 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 230000035800 maturation Effects 0.000 claims 3
- 239000012528 membrane Substances 0.000 claims 3
- 201000004384 Alopecia Diseases 0.000 claims 2
- 208000024827 Alzheimer disease Diseases 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 2
- 208000008589 Obesity Diseases 0.000 claims 2
- 230000005856 abnormality Effects 0.000 claims 2
- 239000000556 agonist Substances 0.000 claims 2
- 125000000539 amino acid group Chemical group 0.000 claims 2
- 239000005557 antagonist Substances 0.000 claims 2
- 239000000427 antigen Substances 0.000 claims 2
- 102000036639 antigens Human genes 0.000 claims 2
- 108091007433 antigens Proteins 0.000 claims 2
- 210000004899 c-terminal region Anatomy 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 238000004590 computer program Methods 0.000 claims 2
- 230000006378 damage Effects 0.000 claims 2
- 230000003247 decreasing effect Effects 0.000 claims 2
- 206010012601 diabetes mellitus Diseases 0.000 claims 2
- 230000004069 differentiation Effects 0.000 claims 2
- 238000009472 formulation Methods 0.000 claims 2
- 230000004927 fusion Effects 0.000 claims 2
- 230000004048 modification Effects 0.000 claims 2
- 238000012986 modification Methods 0.000 claims 2
- 235000020824 obesity Nutrition 0.000 claims 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
- 230000035755 proliferation Effects 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 210000001519 tissue Anatomy 0.000 claims 2
- 230000009261 transgenic effect Effects 0.000 claims 2
- 229920003169 water-soluble polymer Polymers 0.000 claims 2
- 206010000599 Acromegaly Diseases 0.000 claims 1
- 208000003918 Acute Kidney Tubular Necrosis Diseases 0.000 claims 1
- 206010001052 Acute respiratory distress syndrome Diseases 0.000 claims 1
- 201000001320 Atherosclerosis Diseases 0.000 claims 1
- 206010006895 Cachexia Diseases 0.000 claims 1
- 208000011231 Crohn disease Diseases 0.000 claims 1
- 229920002307 Dextran Polymers 0.000 claims 1
- 206010016654 Fibrosis Diseases 0.000 claims 1
- 208000035150 Hypercholesterolemia Diseases 0.000 claims 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- 206010028116 Mucosal inflammation Diseases 0.000 claims 1
- 201000010927 Mucositis Diseases 0.000 claims 1
- 208000001132 Osteoporosis Diseases 0.000 claims 1
- 208000012868 Overgrowth Diseases 0.000 claims 1
- 208000018737 Parkinson disease Diseases 0.000 claims 1
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- 206010038540 Renal tubular necrosis Diseases 0.000 claims 1
- 208000013616 Respiratory Distress Syndrome Diseases 0.000 claims 1
- 206010039491 Sarcoma Diseases 0.000 claims 1
- 206010039966 Senile dementia Diseases 0.000 claims 1
- 208000020221 Short stature Diseases 0.000 claims 1
- 231100000644 Toxic injury Toxicity 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 201000000028 adult respiratory distress syndrome Diseases 0.000 claims 1
- 231100000360 alopecia Toxicity 0.000 claims 1
- 230000001668 ameliorated effect Effects 0.000 claims 1
- 239000003098 androgen Substances 0.000 claims 1
- 239000003963 antioxidant agent Substances 0.000 claims 1
- 230000003078 antioxidant effect Effects 0.000 claims 1
- 206010006475 bronchopulmonary dysplasia Diseases 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 230000004663 cell proliferation Effects 0.000 claims 1
- 238000002512 chemotherapy Methods 0.000 claims 1
- 230000007882 cirrhosis Effects 0.000 claims 1
- 208000019425 cirrhosis of liver Diseases 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 230000004064 dysfunction Effects 0.000 claims 1
- 210000000981 epithelium Anatomy 0.000 claims 1
- 210000003527 eukaryotic cell Anatomy 0.000 claims 1
- 230000002496 gastric effect Effects 0.000 claims 1
- 230000012010 growth Effects 0.000 claims 1
- 230000003676 hair loss Effects 0.000 claims 1
- 230000004217 heart function Effects 0.000 claims 1
- 210000003958 hematopoietic stem cell Anatomy 0.000 claims 1
- 210000004408 hybridoma Anatomy 0.000 claims 1
- 208000008384 ileus Diseases 0.000 claims 1
- 210000000987 immune system Anatomy 0.000 claims 1
- 230000003053 immunization Effects 0.000 claims 1
- 230000005823 lung abnormality Effects 0.000 claims 1
- 229930182817 methionine Natural products 0.000 claims 1
- 125000001360 methionine group Chemical group N[C@@H](CCSC)C(=O)* 0.000 claims 1
- 230000021332 multicellular organism growth Effects 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 230000004770 neurodegeneration Effects 0.000 claims 1
- 208000015122 neurodegenerative disease Diseases 0.000 claims 1
- 201000002652 newborn respiratory distress syndrome Diseases 0.000 claims 1
- 210000000056 organ Anatomy 0.000 claims 1
- 201000008482 osteoarthritis Diseases 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- 230000002028 premature Effects 0.000 claims 1
- 210000001236 prokaryotic cell Anatomy 0.000 claims 1
- 230000001105 regulatory effect Effects 0.000 claims 1
- 238000007634 remodeling Methods 0.000 claims 1
- 230000002207 retinal effect Effects 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 239000003381 stabilizer Substances 0.000 claims 1
- 230000007103 stamina Effects 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
- 238000002054 transplantation Methods 0.000 claims 1
- 210000005239 tubule Anatomy 0.000 claims 1
- 230000037303 wrinkles Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/391,861 US7408047B1 (en) | 1999-09-07 | 1999-09-07 | Fibroblast growth factor-like polypeptides |
| US09/644,052 US7459540B1 (en) | 1999-09-07 | 2000-08-23 | Fibroblast growth factor-like polypeptides |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001522384A Division JP4793836B2 (ja) | 1999-09-07 | 2000-09-05 | 線維芽細胞増殖因子様ポリペプチド |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008317743A Division JP4943410B2 (ja) | 1999-09-07 | 2008-12-12 | 線維芽細胞増殖因子様ポリペプチド |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007044044A JP2007044044A (ja) | 2007-02-22 |
| JP2007044044A5 true JP2007044044A5 (enExample) | 2007-11-22 |
Family
ID=27013655
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001522384A Expired - Fee Related JP4793836B2 (ja) | 1999-09-07 | 2000-09-05 | 線維芽細胞増殖因子様ポリペプチド |
| JP2006220748A Withdrawn JP2007044044A (ja) | 1999-09-07 | 2006-08-11 | 線維芽細胞増殖因子様ポリペプチド |
| JP2008317743A Expired - Fee Related JP4943410B2 (ja) | 1999-09-07 | 2008-12-12 | 線維芽細胞増殖因子様ポリペプチド |
| JP2010084503A Pending JP2010213705A (ja) | 1999-09-07 | 2010-03-31 | 線維芽細胞増殖因子様ポリペプチド |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001522384A Expired - Fee Related JP4793836B2 (ja) | 1999-09-07 | 2000-09-05 | 線維芽細胞増殖因子様ポリペプチド |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008317743A Expired - Fee Related JP4943410B2 (ja) | 1999-09-07 | 2008-12-12 | 線維芽細胞増殖因子様ポリペプチド |
| JP2010084503A Pending JP2010213705A (ja) | 1999-09-07 | 2010-03-31 | 線維芽細胞増殖因子様ポリペプチド |
Country Status (13)
| Country | Link |
|---|---|
| US (10) | US7459540B1 (enExample) |
| EP (4) | EP2258722A3 (enExample) |
| JP (4) | JP4793836B2 (enExample) |
| AT (1) | ATE430197T1 (enExample) |
| AU (1) | AU7350000A (enExample) |
| CA (1) | CA2383774C (enExample) |
| CY (1) | CY1109166T1 (enExample) |
| DE (1) | DE60042122D1 (enExample) |
| DK (1) | DK1218509T3 (enExample) |
| ES (1) | ES2326407T3 (enExample) |
| MX (1) | MXPA02002384A (enExample) |
| PT (1) | PT1218509E (enExample) |
| WO (1) | WO2001018172A2 (enExample) |
Families Citing this family (91)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7459540B1 (en) | 1999-09-07 | 2008-12-02 | Amgen Inc. | Fibroblast growth factor-like polypeptides |
| DE60043197D1 (enExample) * | 1999-11-18 | 2009-12-03 | Univ Kyoto | |
| US6716626B1 (en) | 1999-11-18 | 2004-04-06 | Chiron Corporation | Human FGF-21 nucleic acids |
| US9453251B2 (en) | 2002-10-08 | 2016-09-27 | Pfenex Inc. | Expression of mammalian proteins in Pseudomonas fluorescens |
| EP1656560A2 (en) * | 2003-05-22 | 2006-05-17 | Agilent Technologies, Inc. | Diagnostic markers and pharmacological targets in heart failure and related reagents and methods of use thereof |
| CA2549249A1 (en) | 2003-12-10 | 2005-07-07 | Eli Lilly And Company | Muteins of fibroblast growth factor 21 |
| US7576190B2 (en) | 2004-05-13 | 2009-08-18 | Eli Lilly And Company | FGF-21 fusion proteins |
| JP2008507294A (ja) | 2004-07-26 | 2008-03-13 | ダウ グローバル テクノロジーズ インコーポレイティド | 菌株遺伝子操作による改善されたタンパク質発現のための方法 |
| US7622445B2 (en) | 2004-09-02 | 2009-11-24 | Eli Lilly And Company | Muteins of fibroblast growth factor 21 |
| ATE444307T1 (de) | 2004-09-02 | 2009-10-15 | Lilly Co Eli | Muteine des fibroblasten-wachstumsfaktors 21 |
| JP2008522617A (ja) | 2004-12-14 | 2008-07-03 | イーライ リリー アンド カンパニー | 線維芽細胞成長因子２１の突然変異タンパク質 |
| EP1846019A2 (en) * | 2005-01-21 | 2007-10-24 | Eli Lilly And Company | Method for treating cardiovascular disease |
| JP2006246823A (ja) * | 2005-03-11 | 2006-09-21 | Kyoto Univ | 造血因子としてのＦｇｆ２１の使用 |
| TWI388568B (zh) | 2006-02-10 | 2013-03-11 | Genentech Inc | 抗ｆｇｆ１９抗體及其使用方法 |
| SI2068909T1 (sl) * | 2007-03-30 | 2012-09-28 | Ambrx Inc | Modificirani fgf-21 polipeptidi in njihova uporaba |
| AU2012268895B2 (en) * | 2007-03-30 | 2015-07-16 | Ambrx, Inc. | Modified FGF-21 polypeptides and their uses |
| JP2010523084A (ja) | 2007-03-30 | 2010-07-15 | アンブルックス，インコーポレイテッド | 修飾ｆｇｆ−２１ポリペプチド |
| US9580719B2 (en) | 2007-04-27 | 2017-02-28 | Pfenex, Inc. | Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins |
| EP2615172A1 (en) | 2007-04-27 | 2013-07-17 | Pfenex Inc. | Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins |
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| UA109888C2 (uk) | 2009-12-07 | 2015-10-26 | ІЗОЛЬОВАНЕ АНТИТІЛО АБО ЙОГО ФРАГМЕНТ, ЩО ЗВ'ЯЗУЄТЬСЯ З β-КЛОТО, РЕЦЕПТОРАМИ FGF І ЇХНІМИ КОМПЛЕКСАМИ | |
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2007
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2008
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