SI2068909T1 - Modificirani fgf-21 polipeptidi in njihova uporaba - Google Patents

Modificirani fgf-21 polipeptidi in njihova uporaba

Info

Publication number
SI2068909T1
SI2068909T1 SI200830701T SI200830701T SI2068909T1 SI 2068909 T1 SI2068909 T1 SI 2068909T1 SI 200830701 T SI200830701 T SI 200830701T SI 200830701 T SI200830701 T SI 200830701T SI 2068909 T1 SI2068909 T1 SI 2068909T1
Authority
SI
Slovenia
Prior art keywords
polypeptides
modified fgf
fgf
modified
Prior art date
Application number
SI200830701T
Other languages
English (en)
Inventor
Thomas P Cujec
Roberto Mariani
Putnam Anna-Maria A Hays
William M Keefe
Nick Knudsen
Lillian Ho
Jason Pinkstaff
Vadim Kraynov
Original Assignee
Ambrx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ambrx Inc filed Critical Ambrx Inc
Priority claimed from EP08732507A external-priority patent/EP2068909B1/en
Publication of SI2068909T1 publication Critical patent/SI2068909T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factor [FGF]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
SI200830701T 2007-03-30 2008-03-19 Modificirani fgf-21 polipeptidi in njihova uporaba SI2068909T1 (sl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US92129707P 2007-03-30 2007-03-30
US98806007P 2007-11-14 2007-11-14
EP08732507A EP2068909B1 (en) 2007-03-30 2008-03-19 Modified fgf-21 polypeptides and their uses
PCT/US2008/057563 WO2008121563A2 (en) 2007-03-30 2008-03-19 Modified fgf-21 polypeptides and their uses

Publications (1)

Publication Number Publication Date
SI2068909T1 true SI2068909T1 (sl) 2012-09-28

Family

ID=41790591

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200830701T SI2068909T1 (sl) 2007-03-30 2008-03-19 Modificirani fgf-21 polipeptidi in njihova uporaba

Country Status (2)

Country Link
CN (1) CN101663046B (sl)
SI (1) SI2068909T1 (sl)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103415300B (zh) * 2010-07-20 2018-02-23 诺沃—诺迪斯克有限公司 N‑末端修饰的fgf21化合物
CN102464712A (zh) * 2010-11-11 2012-05-23 重庆富进生物医药有限公司 缺失型人成纤维细胞生长因子21变异体及其偶联物
TWI527590B (zh) * 2011-06-17 2016-04-01 艾瑞斯貿易公司 Ｆｇｆ－１８之凍乾調配物
CN102603886B (zh) * 2012-02-14 2013-08-07 东北农业大学 突变的成纤维细胞生长因子及在治疗ii型糖尿病中的用途
SG11201504815QA (en) * 2012-12-27 2015-07-30 Ngm Biopharmaceuticals Inc Methods for modulating bile acid homeostasis and treatment of bile acid disorders and diseases
CN103882015B (zh) * 2013-12-17 2015-12-02 吉林省奇健生物技术有限公司 一种高效表达人生长激素的重组工程菌及构建方法和应用
HUE044783T2 (hu) 2014-12-23 2019-11-28 Novo Nordisk As FGF21 származékok és alkalmazásaik
JP2022506649A (ja) * 2018-11-05 2022-01-17 ブリストル－マイヤーズ スクイブ カンパニー Ｐｅｇ化タンパク質の精製方法
CN111187845B (zh) * 2020-02-05 2023-03-31 内蒙古农业大学 Fgf21基因在产毛动物选育和/或调节毛发长短中的应用
CN114699509A (zh) * 2021-09-23 2022-07-05 中南大学湘雅三医院 Fgf21调控糖尿病缺血创面细胞焦亡的机制的应用
CN115804847B (zh) * 2022-07-26 2023-08-15 四川省医学科学院·四川省人民医院 一种pH/过氧化氢/MMP9时序性响应微球、搭载外泌体的生物载体及应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7459540B1 (en) * 1999-09-07 2008-12-02 Amgen Inc. Fibroblast growth factor-like polypeptides
EP2163626A1 (en) * 1999-11-18 2010-03-17 Novartis Vaccines and Diagnostics, Inc. Human FGF-21 gene and gene expression products
CN101001866A (zh) * 2004-02-02 2007-07-18 Ambrx公司 经修饰的人类干扰素多肽和其用途
JP2007531715A (ja) * 2004-03-17 2007-11-08 イーライ リリー アンド カンパニー グリコール結合ｆｇｆ−２１化合物
EP1814573B1 (en) * 2004-10-29 2016-03-09 ratiopharm GmbH Remodeling and glycopegylation of fibroblast growth factor (fgf)

Also Published As

Publication number Publication date
CN101663046B (zh) 2017-07-28
CN101663046A (zh) 2010-03-03

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