JP2006506465A5 - - Google Patents
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- JP2006506465A5 JP2006506465A5 JP2005505532A JP2005505532A JP2006506465A5 JP 2006506465 A5 JP2006506465 A5 JP 2006506465A5 JP 2005505532 A JP2005505532 A JP 2005505532A JP 2005505532 A JP2005505532 A JP 2005505532A JP 2006506465 A5 JP2006506465 A5 JP 2006506465A5
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- JP
- Japan
- Prior art keywords
- disease
- tnfα
- pharmaceutical composition
- antibody
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 22
- 239000008194 pharmaceutical composition Substances 0.000 claims 22
- 201000010099 disease Diseases 0.000 claims 21
- 125000003275 alpha amino acid group Chemical group 0.000 claims 16
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 15
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 15
- 206010059176 Juvenile idiopathic arthritis Diseases 0.000 claims 14
- 208000003456 Juvenile Arthritis Diseases 0.000 claims 13
- 201000002215 juvenile rheumatoid arthritis Diseases 0.000 claims 13
- 201000009794 Idiopathic Pulmonary Fibrosis Diseases 0.000 claims 12
- 201000004681 Psoriasis Diseases 0.000 claims 12
- 208000019069 chronic childhood arthritis Diseases 0.000 claims 12
- 208000036971 interstitial lung disease 2 Diseases 0.000 claims 12
- 239000000427 antigen Substances 0.000 claims 11
- 102000036639 antigens Human genes 0.000 claims 11
- 108091007433 antigens Proteins 0.000 claims 11
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 7
- 208000011231 Crohn disease Diseases 0.000 claims 7
- 208000002193 Pain Diseases 0.000 claims 7
- 208000007502 anemia Diseases 0.000 claims 7
- 230000001684 chronic effect Effects 0.000 claims 7
- 238000006467 substitution reaction Methods 0.000 claims 7
- 206010002556 Ankylosing Spondylitis Diseases 0.000 claims 6
- 208000009137 Behcet syndrome Diseases 0.000 claims 6
- 201000001263 Psoriatic Arthritis Diseases 0.000 claims 6
- 208000036824 Psoriatic arthropathy Diseases 0.000 claims 6
- 208000006673 asthma Diseases 0.000 claims 6
- 206010012601 diabetes mellitus Diseases 0.000 claims 6
- 208000010710 hepatitis C virus infection Diseases 0.000 claims 6
- 208000037803 restenosis Diseases 0.000 claims 6
- 101000611183 Homo sapiens Tumor necrosis factor Proteins 0.000 claims 5
- 102000057041 human TNF Human genes 0.000 claims 5
- 235000004279 alanine Nutrition 0.000 claims 4
- 125000003295 alanine group Chemical class N[C@@H](C)C(=O)* 0.000 claims 4
- 235000001014 amino acid Nutrition 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 230000003472 neutralizing effect Effects 0.000 claims 4
- 238000002198 surface plasmon resonance spectroscopy Methods 0.000 claims 4
- 239000012634 fragment Substances 0.000 claims 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 206010006895 Cachexia Diseases 0.000 claims 2
- 208000005141 Otitis Diseases 0.000 claims 2
- 206010033645 Pancreatitis Diseases 0.000 claims 2
- 238000003556 assay Methods 0.000 claims 2
- 230000003013 cytotoxicity Effects 0.000 claims 2
- 231100000135 cytotoxicity Toxicity 0.000 claims 2
- 238000010494 dissociation reaction Methods 0.000 claims 2
- 230000005593 dissociations Effects 0.000 claims 2
- 208000019258 ear infection Diseases 0.000 claims 2
- 238000000338 in vitro Methods 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 206010002329 Aneurysm Diseases 0.000 claims 1
- 206010048962 Brain oedema Diseases 0.000 claims 1
- 206010008690 Chondrocalcinosis pyrophosphate Diseases 0.000 claims 1
- 208000005590 Choroidal Neovascularization Diseases 0.000 claims 1
- 206010060823 Choroidal neovascularisation Diseases 0.000 claims 1
- 206010008874 Chronic Fatigue Syndrome Diseases 0.000 claims 1
- 208000000668 Chronic Pancreatitis Diseases 0.000 claims 1
- 201000009273 Endometriosis Diseases 0.000 claims 1
- 206010016654 Fibrosis Diseases 0.000 claims 1
- 206010018364 Glomerulonephritis Diseases 0.000 claims 1
- 208000010159 IgA glomerulonephritis Diseases 0.000 claims 1
- 206010021263 IgA nephropathy Diseases 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 201000006165 Kuhnt-Junius degeneration Diseases 0.000 claims 1
- 208000019693 Lung disease Diseases 0.000 claims 1
- 208000003250 Mixed connective tissue disease Diseases 0.000 claims 1
- 208000034578 Multiple myelomas Diseases 0.000 claims 1
- 201000003793 Myelodysplastic syndrome Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 208000011623 Obstructive Lung disease Diseases 0.000 claims 1
- 206010030113 Oedema Diseases 0.000 claims 1
- 206010058461 Orchitis noninfective Diseases 0.000 claims 1
- 208000003076 Osteolysis Diseases 0.000 claims 1
- 206010048984 Pancreatic abscess Diseases 0.000 claims 1
- 206010033647 Pancreatitis acute Diseases 0.000 claims 1
- 206010033649 Pancreatitis chronic Diseases 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 206010065159 Polychondritis Diseases 0.000 claims 1
- 206010037660 Pyrexia Diseases 0.000 claims 1
- 208000008765 Sciatica Diseases 0.000 claims 1
- 208000034189 Sclerosis Diseases 0.000 claims 1
- 208000021386 Sjogren Syndrome Diseases 0.000 claims 1
- 208000006045 Spondylarthropathies Diseases 0.000 claims 1
- 206010044565 Tremor Diseases 0.000 claims 1
- 108060008683 Tumor Necrosis Factor Receptor Proteins 0.000 claims 1
- 206010046851 Uveitis Diseases 0.000 claims 1
- 206010047115 Vasculitis Diseases 0.000 claims 1
- 208000000208 Wet Macular Degeneration Diseases 0.000 claims 1
- 208000003152 Yellow Fever Diseases 0.000 claims 1
- 201000003229 acute pancreatitis Diseases 0.000 claims 1
- 206010064930 age-related macular degeneration Diseases 0.000 claims 1
- 230000032683 aging Effects 0.000 claims 1
- 208000006752 brain edema Diseases 0.000 claims 1
- 208000029028 brain injury Diseases 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 208000003167 cholangitis Diseases 0.000 claims 1
- 208000002849 chondrocalcinosis Diseases 0.000 claims 1
- 208000029078 coronary artery disease Diseases 0.000 claims 1
- 201000001981 dermatomyositis Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000004761 fibrosis Effects 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 230000000366 juvenile effect Effects 0.000 claims 1
- 201000006370 kidney failure Diseases 0.000 claims 1
- 208000019423 liver disease Diseases 0.000 claims 1
- 206010025135 lupus erythematosus Diseases 0.000 claims 1
- 208000029791 lytic metastatic bone lesion Diseases 0.000 claims 1
- 208000030159 metabolic disease Diseases 0.000 claims 1
- 206010063344 microscopic polyangiitis Diseases 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 208000029766 myalgic encephalomeyelitis/chronic fatigue syndrome Diseases 0.000 claims 1
- 208000026721 nail disease Diseases 0.000 claims 1
- 201000008383 nephritis Diseases 0.000 claims 1
- 210000000056 organ Anatomy 0.000 claims 1
- 208000025487 periodic fever syndrome Diseases 0.000 claims 1
- 208000028169 periodontal disease Diseases 0.000 claims 1
- 208000005987 polymyositis Diseases 0.000 claims 1
- 201000007094 prostatitis Diseases 0.000 claims 1
- 208000009954 pyoderma gangrenosum Diseases 0.000 claims 1
- 208000009169 relapsing polychondritis Diseases 0.000 claims 1
- 208000004124 rheumatic heart disease Diseases 0.000 claims 1
- 201000000306 sarcoidosis Diseases 0.000 claims 1
- 208000017520 skin disease Diseases 0.000 claims 1
- 210000000278 spinal cord Anatomy 0.000 claims 1
- 201000005671 spondyloarthropathy Diseases 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
- 102000003298 tumor necrosis factor receptor Human genes 0.000 claims 1
- 238000002255 vaccination Methods 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39727502P | 2002-07-19 | 2002-07-19 | |
| US41108102P | 2002-09-16 | 2002-09-16 | |
| US41749002P | 2002-10-10 | 2002-10-10 | |
| US45577703P | 2003-03-18 | 2003-03-18 | |
| PCT/US2003/022566 WO2004009776A2 (en) | 2002-07-19 | 2003-07-18 | TREATMENT OF TNFα RELATED DISORDERS |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010057713A Division JP2010209070A (ja) | 2002-07-19 | 2010-03-15 | ＴＮＦα関連疾患の治療 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006506465A JP2006506465A (ja) | 2006-02-23 |
| JP2006506465A5 true JP2006506465A5 (enExample) | 2006-09-14 |
Family
ID=30773676
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005505532A Withdrawn JP2006506465A (ja) | 2002-07-19 | 2003-07-18 | ＴＮＦα関連疾患の治療 |
| JP2010057713A Pending JP2010209070A (ja) | 2002-07-19 | 2010-03-15 | ＴＮＦα関連疾患の治療 |
| JP2012225755A Withdrawn JP2013056892A (ja) | 2002-07-19 | 2012-10-11 | ＴＮＦα関連疾患の治療 |
| JP2015116695A Pending JP2015221798A (ja) | 2002-07-19 | 2015-06-09 | ＴＮＦα関連疾患の治療 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010057713A Pending JP2010209070A (ja) | 2002-07-19 | 2010-03-15 | ＴＮＦα関連疾患の治療 |
| JP2012225755A Withdrawn JP2013056892A (ja) | 2002-07-19 | 2012-10-11 | ＴＮＦα関連疾患の治療 |
| JP2015116695A Pending JP2015221798A (ja) | 2002-07-19 | 2015-06-09 | ＴＮＦα関連疾患の治療 |
Country Status (22)
| Country | Link |
|---|---|
| US (16) | US20040131614A1 (enExample) |
| EP (6) | EP2371859A3 (enExample) |
| JP (4) | JP2006506465A (enExample) |
| KR (6) | KR20110027851A (enExample) |
| CN (4) | CN101745112A (enExample) |
| AR (2) | AR040603A1 (enExample) |
| AU (2) | AU2003267999B2 (enExample) |
| BR (1) | BR0312785A (enExample) |
| CA (4) | CA2493067A1 (enExample) |
| DK (1) | DK1944322T3 (enExample) |
| ES (1) | ES2535365T3 (enExample) |
| HK (1) | HK1215265A1 (enExample) |
| IL (4) | IL166280A (enExample) |
| MX (2) | MXPA05000815A (enExample) |
| MY (2) | MY169308A (enExample) |
| NZ (5) | NZ555692A (enExample) |
| PL (3) | PL217223B1 (enExample) |
| PT (1) | PT1944322E (enExample) |
| SI (1) | SI1944322T1 (enExample) |
| TW (3) | TWI430810B (enExample) |
| WO (1) | WO2004009776A2 (enExample) |
| ZA (1) | ZA200500068B (enExample) |
Families Citing this family (199)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6090382A (en) | 1996-02-09 | 2000-07-18 | Basf Aktiengesellschaft | Human antibodies that bind human TNFα |
| DE69721548T2 (de) | 1996-02-09 | 2004-04-01 | Abbott Laboratories(Bermuda)Ltd. | HUMANE ANTIKÖRPER WELCHE AN HUMANEN TNFalpha BINDEN |
| US7115557B2 (en) * | 1998-09-25 | 2006-10-03 | Sciaticon Ab | Use of certain drugs for treating nerve root injury |
| US20050226845A1 (en) * | 2004-03-10 | 2005-10-13 | Chih-Ping Liu | Method of treatment using interferon-tau |
| US7199102B2 (en) * | 2000-08-24 | 2007-04-03 | The Regents Of The University Of California | Orally administered peptides synergize statin activity |
| US7148197B2 (en) * | 2000-08-24 | 2006-12-12 | The Regents Of The University Of California | Orally administered small peptides synergize statin activity |
| US8568766B2 (en) | 2000-08-24 | 2013-10-29 | Gattadahalli M. Anantharamaiah | Peptides and peptide mimetics to treat pathologies associated with eye disease |
| US7723303B2 (en) * | 2000-08-24 | 2010-05-25 | The Regents Of The University Of California | Peptides and peptide mimetics to treat pathologies characterized by an inflammatory response |
| CA2868614A1 (en) | 2001-06-08 | 2002-12-08 | Abbott Laboratories (Bermuda) Ltd. | Methods of administering anti-tnf.alpha. antibodies |
| US20060241074A1 (en) * | 2001-08-14 | 2006-10-26 | The General Hospital Corporation | Methods for treatment of pain |
| MY140561A (en) | 2002-02-20 | 2009-12-31 | Nycomed Gmbh | Dosage form containing pde 4 inhibitor as active ingredient |
| US20040009172A1 (en) * | 2002-04-26 | 2004-01-15 | Steven Fischkoff | Use of anti-TNFalpha antibodies and another drug |
| US9028822B2 (en) | 2002-06-28 | 2015-05-12 | Domantis Limited | Antagonists against TNFR1 and methods of use therefor |
| US20090280065A1 (en) * | 2006-04-10 | 2009-11-12 | Willian Mary K | Uses and Compositions for Treatment of Psoriasis |
| CN101745112A (zh) * | 2002-07-19 | 2010-06-23 | 艾博特生物技术有限公司 | TNFα相关疾病的治疗 |
| US20040033228A1 (en) | 2002-08-16 | 2004-02-19 | Hans-Juergen Krause | Formulation of human antibodies for treating TNF-alpha associated disorders |
| US20050271660A1 (en) | 2002-09-06 | 2005-12-08 | Alexion Pharmaceuticals, Inc. | Nebulization of monoclonal antibodies for treating pulmonary diseases |
| US9415102B2 (en) | 2002-09-06 | 2016-08-16 | Alexion Pharmaceuticals, Inc. | High concentration formulations of anti-C5 antibodies |
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| DE10303974A1 (de) | 2003-01-31 | 2004-08-05 | Abbott Gmbh & Co. Kg | Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung |
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| US20040229878A1 (en) * | 2003-05-13 | 2004-11-18 | Depuy Spine, Inc. | Transdiscal administration of specific inhibitors of P38 kinase |
| US7553827B2 (en) * | 2003-08-13 | 2009-06-30 | Depuy Spine, Inc. | Transdiscal administration of cycline compounds |
| US8361467B2 (en) * | 2003-07-30 | 2013-01-29 | Depuy Spine, Inc. | Trans-capsular administration of high specificity cytokine inhibitors into orthopedic joints |
| EP1670499A4 (en) | 2003-08-04 | 2009-07-22 | Bristol Myers Squibb Co | METHODS OF TREATING A CARDIOVASCULAR DISEASE USING A SOLUBLE CTLA4 MOLECULE |
| US7396819B2 (en) * | 2003-08-08 | 2008-07-08 | Virbac Corporation | Anthelmintic formulations |
| US20070208057A1 (en) * | 2003-11-06 | 2007-09-06 | Zeldis Jerome B | Methods And Compositions Using Thalidomide For The Treatment And Management Of Cancers And Other Diseases |
| US8895540B2 (en) * | 2003-11-26 | 2014-11-25 | DePuy Synthes Products, LLC | Local intraosseous administration of bone forming agents and anti-resorptive agents, and devices therefor |
| WO2005094210A2 (en) * | 2004-03-12 | 2005-10-13 | The Hartz Mountain Corporation | Multi-action anthelmintic formulations |
| TW201705980A (zh) | 2004-04-09 | 2017-02-16 | 艾伯維生物技術有限責任公司 | 用於治療ＴＮＦα相關失調症之多重可變劑量療法 |
| GB0414054D0 (en) | 2004-06-23 | 2004-07-28 | Owen Mumford Ltd | Improvements relating to automatic injection devices |
| TWI307630B (en) * | 2004-07-01 | 2009-03-21 | Glaxo Group Ltd | Immunoglobulins |
| US9089636B2 (en) | 2004-07-02 | 2015-07-28 | Valeritas, Inc. | Methods and devices for delivering GLP-1 and uses thereof |
| US20060046961A1 (en) * | 2004-09-02 | 2006-03-02 | Mckay William F | Controlled and directed local delivery of anti-inflammatory compositions |
| US20060205669A1 (en) * | 2004-09-16 | 2006-09-14 | The Regents Of The University Of California | G-type peptides and other agents to ameliorate atherosclerosis and other pathologies |
| DE102004046235A1 (de) * | 2004-09-22 | 2006-03-30 | Altana Pharma Ag | Arzneimittelzubereitung |
| US20060083741A1 (en) * | 2004-10-08 | 2006-04-20 | Hoffman Rebecca S | Treatment of respiratory syncytial virus (RSV) infection |
| RU2414236C2 (ru) | 2004-12-06 | 2011-03-20 | Зе Риджентс Оф Зи Юнивесити Оф Кэлифонье | Способ улучшения структуры и/или функций артериол |
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| AU2006230419A1 (en) * | 2005-03-31 | 2006-10-05 | Targeted Genetics Corporation | Methods for lowering the level of tumor necrosis factor (TNF) in TNF-associated disorders |
| US20080293639A1 (en) * | 2005-04-29 | 2008-11-27 | The Regents Of The University Of California | Peptides and peptide mimetics to treat pathologies characterized by an inflammatory response |
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| KR20080090408A (ko) | 2005-11-30 | 2008-10-08 | 아보트 러보러터리즈 | 항-Ａβ 글로불로머 항체, 이의 항원-결합 잔기, 상응하는하이브리도마, 핵산, 벡터, 숙주 세포, 당해 항체의 제조방법, 당해 항체를 포함하는 조성물, 당해 항체의 용도 및당해 항체의 사용 방법 |
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| US8795668B2 (en) * | 2005-12-23 | 2014-08-05 | The Regents Of The University Of Michigan | Methods for treating pulmonary fibrosis |
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| US9624295B2 (en) | 2006-04-10 | 2017-04-18 | Abbvie Biotechnology Ltd. | Uses and compositions for treatment of psoriatic arthritis |
| US9399061B2 (en) | 2006-04-10 | 2016-07-26 | Abbvie Biotechnology Ltd | Methods for determining efficacy of TNF-α inhibitors for treatment of rheumatoid arthritis |
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| US20080311043A1 (en) * | 2006-06-08 | 2008-12-18 | Hoffman Rebecca S | Uses and compositions for treatment of psoriatic arthritis |
| US20100021451A1 (en) * | 2006-06-08 | 2010-01-28 | Wong Robert L | Uses and compositions for treatment of ankylosing spondylitis |
| KR101440795B1 (ko) * | 2006-06-30 | 2014-09-22 | 애브비 바이오테크놀로지 리미티드 | 자동 주사 장치 |
| KR20090101893A (ko) * | 2006-10-27 | 2009-09-29 | 애보트 바이오테크놀로지 리미티드 | 결정형 항-ｈＴＮＦ알파 항체 |
| US8455626B2 (en) | 2006-11-30 | 2013-06-04 | Abbott Laboratories | Aβ conformer selective anti-aβ globulomer monoclonal antibodies |
| CN101200465B (zh) * | 2006-12-11 | 2010-12-29 | 和记黄埔医药（上海）有限公司 | 一种十氢化萘类化合物及其医药用途 |
| WO2008104386A2 (en) | 2007-02-27 | 2008-09-04 | Abbott Gmbh & Co. Kg | Method for the treatment of amyloidoses |
| EP2527364A1 (en) | 2007-03-29 | 2012-11-28 | Abbott Laboratories | Crystalline anti-human IL-12 antibodies |
| US20080254011A1 (en) * | 2007-04-11 | 2008-10-16 | Peter Rothschild | Use of selected lactic acid bacteria for reducing atherosclerosis |
| WO2008141511A1 (fr) * | 2007-05-22 | 2008-11-27 | Human Antibodomics (Shanghai) Inc. | ANTICORPS MONOCLONAL HUMAIN ANTI-TNFα ET SON UTILISATION |
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2003
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