JP2005270110A5 - - Google Patents
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- Publication number
- JP2005270110A5 JP2005270110A5 JP2005122294A JP2005122294A JP2005270110A5 JP 2005270110 A5 JP2005270110 A5 JP 2005270110A5 JP 2005122294 A JP2005122294 A JP 2005122294A JP 2005122294 A JP2005122294 A JP 2005122294A JP 2005270110 A5 JP2005270110 A5 JP 2005270110A5
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- polypeptide conjugate
- cell
- host cell
- medicament
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 229920001184 polypeptide Polymers 0.000 claims 19
- 102000004196 processed proteins & peptides Human genes 0.000 claims 19
- 108090000765 processed proteins & peptides Proteins 0.000 claims 19
- 230000004988 N-glycosylation Effects 0.000 claims 8
- 210000004027 cell Anatomy 0.000 claims 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 8
- 238000006467 substitution reaction Methods 0.000 claims 6
- 239000003814 drug Substances 0.000 claims 5
- 201000010099 disease Diseases 0.000 claims 4
- 208000035475 disorder Diseases 0.000 claims 4
- 125000003275 alpha amino acid group Chemical group 0.000 claims 3
- 239000002773 nucleotide Substances 0.000 claims 3
- 125000003729 nucleotide group Chemical group 0.000 claims 3
- 239000013604 expression vector Substances 0.000 claims 2
- 229940099816 human factor vii Drugs 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 108010054265 Factor VIIa Proteins 0.000 claims 1
- 208000031220 Hemophilia Diseases 0.000 claims 1
- 208000009292 Hemophilia A Diseases 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 208000027418 Wounds and injury Diseases 0.000 claims 1
- 125000000539 amino acid group Chemical group 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 210000004978 chinese hamster ovary cell Anatomy 0.000 claims 1
- 230000035602 clotting Effects 0.000 claims 1
- 230000015271 coagulation Effects 0.000 claims 1
- 238000005345 coagulation Methods 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 230000006378 damage Effects 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 229940012414 factor viia Drugs 0.000 claims 1
- 230000013595 glycosylation Effects 0.000 claims 1
- 238000006206 glycosylation reaction Methods 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 208000014674 injury Diseases 0.000 claims 1
- 210000004962 mammalian cell Anatomy 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 238000001356 surgical procedure Methods 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200000218 | 2000-02-11 | ||
| DKPA200001558 | 2000-10-18 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001558082A Division JP2003521930A (ja) | 2000-02-11 | 2001-02-12 | 第VII因子または第VIIa因子様分子 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005270110A JP2005270110A (ja) | 2005-10-06 |
| JP2005270110A5 true JP2005270110A5 (enExample) | 2008-03-27 |
| JP4509846B2 JP4509846B2 (ja) | 2010-07-21 |
Family
ID=26068765
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001558082A Pending JP2003521930A (ja) | 2000-02-11 | 2001-02-12 | 第VII因子または第VIIa因子様分子 |
| JP2005122294A Expired - Fee Related JP4509846B2 (ja) | 2000-02-11 | 2005-04-20 | 第VII因子または第VIIa因子様分子 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001558082A Pending JP2003521930A (ja) | 2000-02-11 | 2001-02-12 | 第VII因子または第VIIa因子様分子 |
Country Status (18)
| Country | Link |
|---|---|
| US (13) | US6806063B2 (enExample) |
| EP (3) | EP1257295B1 (enExample) |
| JP (2) | JP2003521930A (enExample) |
| CN (1) | CN100488562C (enExample) |
| AT (1) | ATE428445T1 (enExample) |
| AU (3) | AU783512B2 (enExample) |
| CA (2) | CA2739933A1 (enExample) |
| CY (1) | CY1109614T1 (enExample) |
| DE (1) | DE60138364D1 (enExample) |
| DK (1) | DK1257295T3 (enExample) |
| ES (1) | ES2325877T3 (enExample) |
| IL (2) | IL150692A0 (enExample) |
| NO (1) | NO20023804L (enExample) |
| NZ (1) | NZ521257A (enExample) |
| PL (2) | PL206148B1 (enExample) |
| PT (1) | PT1257295E (enExample) |
| RU (1) | RU2278123C2 (enExample) |
| WO (1) | WO2001058935A2 (enExample) |
Families Citing this family (168)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7247708B2 (en) | 1997-10-23 | 2007-07-24 | Regents Of The University Of Minnesota | Modified vitamin K-dependent polypeptides |
| US6747003B1 (en) | 1997-10-23 | 2004-06-08 | Regents Of The University Of Minnesota | Modified vitamin K-dependent polypeptides |
| WO2001004287A1 (en) * | 1999-07-07 | 2001-01-18 | Maxygen Aps | A method for preparing modified polypeptides |
| WO2001058935A2 (en) * | 2000-02-11 | 2001-08-16 | Maxygen Aps | FACTOR VII OR VIIa-LIKE MOLECULES |
| US7220837B1 (en) | 2000-04-28 | 2007-05-22 | Regents Of The University Of Minnesota | Modified vitamin K-dependent polypeptides |
| US7812132B2 (en) | 2000-04-28 | 2010-10-12 | Regents Of The University Of Minnesota | Modified vitamin K-dependent polypeptides |
| US6905683B2 (en) * | 2000-05-03 | 2005-06-14 | Novo Nordisk Healthcare A/G | Human coagulation factor VII variants |
| US7160540B2 (en) | 2000-06-30 | 2007-01-09 | Regents Of The University Of Minnesota | Methods for detecting activity of clottings factors |
| US6423826B1 (en) * | 2000-06-30 | 2002-07-23 | Regents Of The University Of Minnesota | High molecular weight derivatives of vitamin K-dependent polypeptides |
| US20030211094A1 (en) * | 2001-06-26 | 2003-11-13 | Nelsestuen Gary L. | High molecular weight derivatives of vitamin k-dependent polypeptides |
| EP1319067A2 (en) * | 2000-09-13 | 2003-06-18 | Novo Nordisk A/S | Human coagulation factor vii variants |
| US7176288B2 (en) | 2000-09-13 | 2007-02-13 | Novo Nordisk Healthcare A/G | Human coagulation factor VII variants |
| US7173000B2 (en) * | 2000-11-09 | 2007-02-06 | The Scripps Research Institute | Modified factor VIIa |
| WO2002077218A1 (en) * | 2001-03-22 | 2002-10-03 | Novo Nordisk Health Care Ag | Coagulation factor vii derivatives |
| US7235638B2 (en) * | 2001-03-22 | 2007-06-26 | Novo Nordisk Healthcare A/G | Coagulation factor VII derivatives |
| US7052868B2 (en) * | 2001-09-27 | 2006-05-30 | Novo Nordisk Healthcare A/G | Human coagulation factor VII polypeptides |
| JP4537059B2 (ja) * | 2001-09-27 | 2010-09-01 | ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト | ヒト凝固第vii因子ポリペプチド |
| US7795210B2 (en) | 2001-10-10 | 2010-09-14 | Novo Nordisk A/S | Protein remodeling methods and proteins/peptides produced by the methods |
| US7173003B2 (en) | 2001-10-10 | 2007-02-06 | Neose Technologies, Inc. | Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF |
| ES2561985T3 (es) * | 2001-10-10 | 2016-03-01 | Ratiopharm Gmbh | Remodelación y glicoconjugación de anticuerpos |
| US7696163B2 (en) | 2001-10-10 | 2010-04-13 | Novo Nordisk A/S | Erythropoietin: remodeling and glycoconjugation of erythropoietin |
| US7214660B2 (en) | 2001-10-10 | 2007-05-08 | Neose Technologies, Inc. | Erythropoietin: remodeling and glycoconjugation of erythropoietin |
| US8008252B2 (en) | 2001-10-10 | 2011-08-30 | Novo Nordisk A/S | Factor VII: remodeling and glycoconjugation of Factor VII |
| US7157277B2 (en) | 2001-11-28 | 2007-01-02 | Neose Technologies, Inc. | Factor VIII remodeling and glycoconjugation of Factor VIII |
| JP2005512524A (ja) | 2001-11-02 | 2005-05-12 | ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト | ヒト凝固第vii因子ポリペプチド |
| US6960657B2 (en) * | 2001-11-02 | 2005-11-01 | Novo Nordisk Healthcare A/G | Human coagulation factor VII polypeptides |
| US7125846B2 (en) | 2001-11-09 | 2006-10-24 | Novo Nordisk Healthcare A/G | Pharmaceutical composition comprising factor VII polypeptides and factor V polypeptides |
| KR20040065278A (ko) * | 2001-12-21 | 2004-07-21 | 노보 노르디스크 에이/에스 | 변경된 인자 ⅶ 폴리펩티드의 액체 조성물 |
| DE60232017D1 (de) | 2001-12-21 | 2009-05-28 | Novo Nordisk Healthcare Ag | Flüssige zusammensetzung aus faktor vii polypeptiden |
| US20050069551A1 (en) * | 2002-03-08 | 2005-03-31 | Emory University | Cytotoxic compound-protein conjugates as suppressors of tumor growth and angiogenesis |
| CA2478522A1 (en) * | 2002-03-08 | 2003-09-18 | Emory University | Novel curcuminoid-factor viia constructs as suppressors of tumor growth and angiogenesis |
| PL373728A1 (en) * | 2002-04-30 | 2005-09-05 | Maxygen Holdings Ltd. | Factor vii or viia polypeptide variants |
| US20040009918A1 (en) * | 2002-05-03 | 2004-01-15 | Hanne Nedergaard | Stabilised solid compositions of modified factor VII |
| MXPA04012496A (es) | 2002-06-21 | 2005-09-12 | Novo Nordisk Healthcare Ag | Glicoformos del factor vii pegilados. |
| PL207018B1 (pl) | 2002-06-21 | 2010-10-29 | Novo Nordisk Helth Care Ag | Kompozycja farmaceutyczna, sposób przygotowania stabilnego polipeptydu czynnika VII i zastosowanie polipeptydu czynnika VII |
| CN1671420A (zh) | 2002-06-21 | 2005-09-21 | 诺和诺德医疗保健公司 | Peg化因子ⅶ糖型 |
| ES2339393T3 (es) * | 2002-09-25 | 2010-05-19 | Novo Nordisk Health Care Ag | Polipeptidos del factor de coagulacion humano vii. |
| US6911323B2 (en) * | 2002-09-25 | 2005-06-28 | Novo Nordisk Healthcare A/G | Human coagulation factor VII polypeptides |
| ATE505487T1 (de) * | 2002-09-30 | 2011-04-15 | Bayer Healthcare Llc | Fvii- oder fviia-varianten mit erhöhter koagulationswirkung |
| CN102212019B (zh) | 2003-03-14 | 2015-05-27 | 蔚所番有限公司 | 支化水溶性聚合物及其缀合物 |
| EP1605968A2 (en) * | 2003-03-18 | 2005-12-21 | Novo Nordisk Health Care AG | Liquid, aqueous, pharmaceutical compositions of factor vii polypeptides |
| KR101204712B1 (ko) | 2003-03-18 | 2012-11-27 | 노보 노르디스크 헬스 케어 악티엔게젤샤프트 | Gla-잔기 함유 세린 프로테아제의 제조 방법 |
| DE602004021099D1 (de) | 2003-03-20 | 2009-06-25 | Bayer Healthcare Llc | Fvii oder fviia varianten |
| US7897734B2 (en) | 2003-03-26 | 2011-03-01 | Novo Nordisk Healthcare Ag | Method for the production of proteins |
| WO2004091499A2 (en) | 2003-04-09 | 2004-10-28 | Neose Technologies, Inc. | Intracellular formation of peptide conjugates |
| SG155777A1 (en) | 2003-04-09 | 2009-10-29 | Neose Technologies Inc | Glycopegylation methods and proteins/peptides produced by the methods |
| US8791070B2 (en) | 2003-04-09 | 2014-07-29 | Novo Nordisk A/S | Glycopegylated factor IX |
| TWI353991B (en) | 2003-05-06 | 2011-12-11 | Syntonix Pharmaceuticals Inc | Immunoglobulin chimeric monomer-dimer hybrids |
| US7348004B2 (en) | 2003-05-06 | 2008-03-25 | Syntonix Pharmaceuticals, Inc. | Immunoglobulin chimeric monomer-dimer hybrids |
| DE602004031390D1 (de) | 2003-05-06 | 2011-03-24 | Syntonix Pharmaceuticals Inc | Gerinnungsfaktor VII-Fc chimäre Proteine zur Behandlung von hämostatischen Krankheiten |
| EP1624847B1 (en) | 2003-05-09 | 2012-01-04 | BioGeneriX AG | Compositions and methods for the preparation of human growth hormone glycosylation mutants |
| CN1780638B (zh) * | 2003-05-23 | 2010-04-14 | 诺和诺德医疗保健公司 | 氧化硅涂层玻璃作为容器内壁材料的用途及以该材料作内壁的容器 |
| WO2004111242A1 (en) * | 2003-06-19 | 2004-12-23 | Maxygen Holdings Ltd. | FACTOR VII OR VIIa GLA DOMAIN VARIANTS |
| JP4658041B2 (ja) | 2003-06-25 | 2011-03-23 | ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト | Vii因子ポリペプチドの液体組成物 |
| EP1644030B1 (en) * | 2003-07-01 | 2009-10-28 | Novo Nordisk Health Care AG | Liquid, aqueous pharmaceutical composition of factor vii polypeptides |
| WO2005012484A2 (en) | 2003-07-25 | 2005-02-10 | Neose Technologies, Inc. | Antibody-toxin conjugates |
| WO2005025623A2 (en) * | 2003-07-28 | 2005-03-24 | Emory University | Ef-24-factor vii conjugates |
| EP1654004A2 (en) * | 2003-08-08 | 2006-05-10 | Novo Nordisk A/S | Synthesis and application of new structural well defined branched polymers as conjugating agents for peptides |
| US20060198819A1 (en) * | 2003-08-08 | 2006-09-07 | Novo Nordisk Healthcare A/G | Use of galactose oxidase for selective chemical conjugation of protractor molecules to proteins of therapeutic interest |
| RU2388460C2 (ru) | 2003-08-14 | 2010-05-10 | Ново Нордиск Хелс Кеа Аг | Жидкая водная фармацевтическая композиция, содержащая полипептид фактора vii |
| JP4824559B2 (ja) * | 2003-09-09 | 2011-11-30 | ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト | 凝固因子viiポリペプチド |
| WO2005024006A2 (en) * | 2003-09-09 | 2005-03-17 | Novo Nordisk Health Care Ag | Coagulation factor vii polypeptides |
| JP2007509843A (ja) * | 2003-10-07 | 2007-04-19 | ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト | 第VII/VIIa因子活性を有するハイブリッド分子 |
| US7842661B2 (en) | 2003-11-24 | 2010-11-30 | Novo Nordisk A/S | Glycopegylated erythropoietin formulations |
| US8633157B2 (en) | 2003-11-24 | 2014-01-21 | Novo Nordisk A/S | Glycopegylated erythropoietin |
| US20080305992A1 (en) | 2003-11-24 | 2008-12-11 | Neose Technologies, Inc. | Glycopegylated erythropoietin |
| PL1711513T3 (pl) | 2003-12-01 | 2014-12-31 | Novo Nordisk Healthcare Ag | Nanofiltracja roztworów czynnika vii w celu usunięcia wirusów |
| US20060040856A1 (en) | 2003-12-03 | 2006-02-23 | Neose Technologies, Inc. | Glycopegylated factor IX |
| US7956032B2 (en) | 2003-12-03 | 2011-06-07 | Novo Nordisk A/S | Glycopegylated granulocyte colony stimulating factor |
| EP2298287B1 (en) | 2003-12-19 | 2018-04-11 | Novo Nordisk Health Care AG | Stabilised compositions of factor VII polypeptides |
| JP5743368B2 (ja) | 2004-01-08 | 2015-07-01 | ラショファーム ゲーエムベーハー | ペプチドのo結合型グリコシル化 |
| CA2552043A1 (en) | 2004-01-21 | 2005-08-04 | Novo Nordisk A/S | Transglutaminase mediated conjugation of peptides |
| KR100545720B1 (ko) * | 2004-05-31 | 2006-01-24 | 메덱스젠 주식회사 | 당화된 면역글로불린 및 이를 포함하는 면역접합체 |
| WO2005123916A2 (en) * | 2004-06-21 | 2005-12-29 | Novo Nordisk Health Care Ag | Glycosylation-disrupted factor vii variants |
| US20080300173A1 (en) | 2004-07-13 | 2008-12-04 | Defrees Shawn | Branched Peg Remodeling and Glycosylation of Glucagon-Like Peptides-1 [Glp-1] |
| US20090176967A1 (en) * | 2004-08-02 | 2009-07-09 | Novo Nordisk Healthcare A/G | Conjugation of FVII |
| JP2008509688A (ja) * | 2004-08-17 | 2008-04-03 | ツェー・エス・エル・ベーリング・ゲー・エム・ベー・ハー | 改変ビタミンk依存性ポリペプチド |
| US8268967B2 (en) | 2004-09-10 | 2012-09-18 | Novo Nordisk A/S | Glycopegylated interferon α |
| HUE026826T2 (en) | 2004-10-29 | 2016-07-28 | Ratiopharm Gmbh | Modeling and glycopegylation of fibroblast growth factor (FGF) |
| SI1824988T1 (sl) * | 2004-11-12 | 2017-11-30 | Bayer Healthcare Llc | Usmerjena modifikacija FVIII |
| JP2008525381A (ja) | 2004-12-23 | 2008-07-17 | ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト | 関心のあるビタミンk依存性タンパク質を含んでなる組成物中におけるタンパク質混入物の量の減少 |
| US9029331B2 (en) | 2005-01-10 | 2015-05-12 | Novo Nordisk A/S | Glycopegylated granulocyte colony stimulating factor |
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| EP1893230A2 (en) * | 2005-04-26 | 2008-03-05 | Maxygen Holdings Ltd. | Use of modified factor vii for treating bleeding |
| EP1891231A4 (en) | 2005-05-25 | 2011-06-22 | Novo Nordisk As | GLYCOPEGYLATED FACTOR IX |
| WO2006134173A2 (en) | 2005-06-17 | 2006-12-21 | Novo Nordisk Health Care Ag | Selective reduction and derivatization of engineered proteins comprising at least one non-native cysteine |
| CN101262880A (zh) * | 2005-06-24 | 2008-09-10 | 德拉格雷丘尔公司 | 在影响呼吸道的炎症病状中气道施用组织因子途径抑制物 |
| ES2397851T3 (es) | 2005-07-13 | 2013-03-11 | Novo Nordisk Health Care Ag | Células de inactivación proteínica de la célula huésped para la producción de proteínas terapéuticas |
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| CN101268185B (zh) | 2005-09-01 | 2013-03-27 | 诺沃-诺迪斯克保健股份有限公司 | 因子ⅶ多肽的疏水作用色谱纯化 |
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| US8777971B2 (en) * | 2006-10-17 | 2014-07-15 | Amj Bv | Device and method for joining vessels in anastomosis |
| CN105838699A (zh) | 2006-12-15 | 2016-08-10 | 巴克斯艾尔塔公司 | 具有延长的体内半衰期的因子VIIa-聚唾液酸结合物 |
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| EP1972687A1 (en) * | 2007-03-23 | 2008-09-24 | GenOdyssee | Polynucleotides and polypeptides of human factor VII gene, SNPs |
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| JP5876649B2 (ja) | 2007-06-12 | 2016-03-02 | ラツィオファルム ゲーエムベーハーratiopharm GmbH | ヌクレオチド糖の改良製造法 |
| AU2008275911A1 (en) * | 2007-07-19 | 2009-01-22 | Arizona Board of Regents, a body corporate acting for and on behalf of Arizona State University | Self- anchoring MEMS intrafascicular neural electrode |
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| AU1262900A (en) | 1998-11-06 | 2000-05-29 | Novo Nordisk A/S | Method for the production of fvii |
| JP2002534966A (ja) | 1999-01-19 | 2002-10-22 | マキシジェン, インコーポレイテッド | オリゴヌクレオチド媒介核酸組換え |
| WO2000054787A1 (en) | 1999-03-16 | 2000-09-21 | The Children's Hospital Of Philadelphia | Enhanced gamma-carboxylation of recombinant vitamin k-dependent clotting factors |
| US6432826B1 (en) * | 1999-11-29 | 2002-08-13 | Applied Materials, Inc. | Planarized Cu cleaning for reduced defects |
| WO2001058935A2 (en) | 2000-02-11 | 2001-08-16 | Maxygen Aps | FACTOR VII OR VIIa-LIKE MOLECULES |
| US7220837B1 (en) | 2000-04-28 | 2007-05-22 | Regents Of The University Of Minnesota | Modified vitamin K-dependent polypeptides |
| AU2001254624A1 (en) | 2000-05-03 | 2001-11-12 | Novo-Nordisk A/S | Human coagulation factor vii variants |
| US7160540B2 (en) | 2000-06-30 | 2007-01-09 | Regents Of The University Of Minnesota | Methods for detecting activity of clottings factors |
| US6423826B1 (en) | 2000-06-30 | 2002-07-23 | Regents Of The University Of Minnesota | High molecular weight derivatives of vitamin K-dependent polypeptides |
| US20030211094A1 (en) | 2001-06-26 | 2003-11-13 | Nelsestuen Gary L. | High molecular weight derivatives of vitamin k-dependent polypeptides |
| EP1319067A2 (en) | 2000-09-13 | 2003-06-18 | Novo Nordisk A/S | Human coagulation factor vii variants |
| US7176288B2 (en) | 2000-09-13 | 2007-02-13 | Novo Nordisk Healthcare A/G | Human coagulation factor VII variants |
| AU2001291653A1 (en) | 2000-10-02 | 2002-04-15 | Novo-Nordisk A/S | Industrial-scale serum-free production of recombinant factor vii in mammalian cells |
| US7173000B2 (en) | 2000-11-09 | 2007-02-06 | The Scripps Research Institute | Modified factor VIIa |
| PL373728A1 (en) | 2002-04-30 | 2005-09-05 | Maxygen Holdings Ltd. | Factor vii or viia polypeptide variants |
| ATE505487T1 (de) | 2002-09-30 | 2011-04-15 | Bayer Healthcare Llc | Fvii- oder fviia-varianten mit erhöhter koagulationswirkung |
| DE602004021099D1 (de) | 2003-03-20 | 2009-06-25 | Bayer Healthcare Llc | Fvii oder fviia varianten |
| WO2004111242A1 (en) | 2003-06-19 | 2004-12-23 | Maxygen Holdings Ltd. | FACTOR VII OR VIIa GLA DOMAIN VARIANTS |
-
2001
- 2001-02-12 WO PCT/DK2001/000094 patent/WO2001058935A2/en not_active Ceased
- 2001-02-12 AU AU31535/01A patent/AU783512B2/en not_active Ceased
- 2001-02-12 RU RU2002124129/04A patent/RU2278123C2/ru not_active IP Right Cessation
- 2001-02-12 PL PL386364A patent/PL206148B1/pl unknown
- 2001-02-12 ES ES01903611T patent/ES2325877T3/es not_active Expired - Lifetime
- 2001-02-12 JP JP2001558082A patent/JP2003521930A/ja active Pending
- 2001-02-12 US US09/782,587 patent/US6806063B2/en not_active Expired - Lifetime
- 2001-02-12 CA CA2739933A patent/CA2739933A1/en not_active Abandoned
- 2001-02-12 EP EP01903611A patent/EP1257295B1/en not_active Expired - Lifetime
- 2001-02-12 CN CNB018048641A patent/CN100488562C/zh not_active Expired - Fee Related
- 2001-02-12 DE DE60138364T patent/DE60138364D1/de not_active Expired - Lifetime
- 2001-02-12 EP EP10180652A patent/EP2319541A1/en not_active Withdrawn
- 2001-02-12 PT PT01903611T patent/PT1257295E/pt unknown
- 2001-02-12 NZ NZ521257A patent/NZ521257A/en not_active IP Right Cessation
- 2001-02-12 PL PL362856A patent/PL204285B1/pl unknown
- 2001-02-12 EP EP08010798A patent/EP1982732A3/en not_active Withdrawn
- 2001-02-12 CA CA2397347A patent/CA2397347C/en not_active Expired - Fee Related
- 2001-02-12 AT AT01903611T patent/ATE428445T1/de active
- 2001-02-12 DK DK01903611T patent/DK1257295T3/da active
- 2001-02-12 IL IL15069201A patent/IL150692A0/xx not_active IP Right Cessation
-
2002
- 2002-08-09 NO NO20023804A patent/NO20023804L/no not_active Application Discontinuation
-
2004
- 2004-09-27 US US10/950,747 patent/US7371543B2/en not_active Expired - Fee Related
-
2005
- 2005-04-20 JP JP2005122294A patent/JP4509846B2/ja not_active Expired - Fee Related
-
2006
- 2006-02-02 AU AU2006200448A patent/AU2006200448B2/en not_active Ceased
- 2006-03-30 US US11/396,314 patent/US7517974B2/en not_active Expired - Fee Related
- 2006-04-12 US US11/279,541 patent/US7511024B2/en not_active Expired - Fee Related
- 2006-04-18 US US11/379,189 patent/US7598056B2/en not_active Expired - Fee Related
- 2006-06-07 US US11/448,143 patent/US20070142280A1/en not_active Abandoned
- 2006-06-12 US US11/423,662 patent/US7442524B2/en not_active Expired - Fee Related
- 2006-06-12 US US11/423,622 patent/US8084591B2/en not_active Expired - Fee Related
- 2006-06-12 US US11/423,665 patent/US7427592B2/en not_active Expired - Fee Related
- 2006-06-26 US US11/426,394 patent/US20060252689A1/en not_active Abandoned
- 2006-06-26 US US11/426,401 patent/US7414022B2/en not_active Expired - Fee Related
-
2007
- 2007-10-30 US US11/928,108 patent/US7754682B2/en not_active Expired - Fee Related
-
2009
- 2009-06-23 IL IL199497A patent/IL199497A/en not_active IP Right Cessation
- 2009-07-14 CY CY20091100736T patent/CY1109614T1/el unknown
-
2010
- 2010-01-27 AU AU2010200296A patent/AU2010200296A1/en not_active Abandoned
-
2011
- 2011-11-18 US US13/299,736 patent/US20120171765A1/en not_active Abandoned
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