ATE263778T1 - Niedrigallergene proteinvarianten - Google Patents

Niedrigallergene proteinvarianten

Info

Publication number
ATE263778T1
ATE263778T1 AT99947260T AT99947260T ATE263778T1 AT E263778 T1 ATE263778 T1 AT E263778T1 AT 99947260 T AT99947260 T AT 99947260T AT 99947260 T AT99947260 T AT 99947260T AT E263778 T1 ATE263778 T1 AT E263778T1
Authority
AT
Austria
Prior art keywords
protein
parent protein
immunogenicity
low
parent
Prior art date
Application number
AT99947260T
Other languages
English (en)
Inventor
Erwin Ludo Roggen
Arne Agerlin Olsen
Steffen Ernst
Original Assignee
Novozymes As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27221271&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE263778(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novozymes As filed Critical Novozymes As
Application granted granted Critical
Publication of ATE263778T1 publication Critical patent/ATE263778T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/02—Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only microorganisms or vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0055—Oxidoreductases (1.) acting on diphenols and related substances as donors (1.10)
    • C12N9/0057—Oxidoreductases (1.) acting on diphenols and related substances as donors (1.10) with oxygen as acceptor (1.10.3)
    • C12N9/0061—Laccase (1.10.3.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2405—Glucanases
    • C12N9/2408—Glucanases acting on alpha -1,4-glucosidic bonds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2405—Glucanases
    • C12N9/2408—Glucanases acting on alpha -1,4-glucosidic bonds
    • C12N9/2411—Amylases
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • C12N9/54—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea bacteria being Bacillus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y110/00—Oxidoreductases acting on diphenols and related substances as donors (1.10)
    • C12Y110/03—Oxidoreductases acting on diphenols and related substances as donors (1.10) with an oxygen as acceptor (1.10.3)
    • C12Y110/03002—Laccase (1.10.3.2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Virology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AT99947260T 1998-10-30 1999-10-12 Niedrigallergene proteinvarianten ATE263778T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DKPA199801402 1998-10-30
DKPA199801645 1998-11-25
DKPA199901417 1999-10-04
PCT/DK1999/000541 WO2000026230A1 (en) 1998-10-30 1999-10-12 Low allergenic protein variants

Publications (1)

Publication Number Publication Date
ATE263778T1 true ATE263778T1 (de) 2004-04-15

Family

ID=27221271

Family Applications (2)

Application Number Title Priority Date Filing Date
AT02020745T ATE390441T1 (de) 1998-10-30 1999-10-12 Niedrigallergene proteinvarianten
AT99947260T ATE263778T1 (de) 1998-10-30 1999-10-12 Niedrigallergene proteinvarianten

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT02020745T ATE390441T1 (de) 1998-10-30 1999-10-12 Niedrigallergene proteinvarianten

Country Status (10)

Country Link
EP (2) EP1277762B1 (de)
JP (1) JP2003500003A (de)
CN (1) CN1206237C (de)
AT (2) ATE390441T1 (de)
AU (1) AU776534B2 (de)
CA (1) CA2348938A1 (de)
DE (2) DE69938435D1 (de)
ES (1) ES2220114T3 (de)
NZ (1) NZ511291A (de)
WO (1) WO2000026230A1 (de)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6747003B1 (en) 1997-10-23 2004-06-08 Regents Of The University Of Minnesota Modified vitamin K-dependent polypeptides
AU2003203147B2 (en) 1998-03-23 2008-05-29 Novozymes A/S Phytase variants
US6835550B1 (en) * 1998-04-15 2004-12-28 Genencor International, Inc. Mutant proteins having lower allergenic response in humans and methods for constructing, identifying and producing such proteins
AU5805500A (en) * 1999-07-07 2001-01-30 Maxygen Aps A method for preparing modified polypeptides
AU779195B2 (en) * 1999-12-09 2005-01-13 Novozymes A/S High throughput screening (HTS) assays for protein variants with reduced antibody binding capacity
RU2278123C2 (ru) 2000-02-11 2006-06-20 Максиджен Холдингз Лтд. Молекулы, подобные фактору vii или viia
US7812132B2 (en) 2000-04-28 2010-10-12 Regents Of The University Of Minnesota Modified vitamin K-dependent polypeptides
ES2588756T3 (es) * 2000-04-28 2016-11-04 Novozymes A/S Variante de enzima lipolítica
US7220837B1 (en) 2000-04-28 2007-05-22 Regents Of The University Of Minnesota Modified vitamin K-dependent polypeptides
CA2412502A1 (en) * 2000-06-21 2001-12-27 Novozymes A/S Method for genome mining for secreted protein genes
US20030211094A1 (en) 2001-06-26 2003-11-13 Nelsestuen Gary L. High molecular weight derivatives of vitamin k-dependent polypeptides
DK1340085T3 (da) * 2000-10-17 2008-12-01 Besst Test Aps Assay til direkte detektion af en biologisk celle i en legemsvæskepröve
US6933367B2 (en) 2000-10-18 2005-08-23 Maxygen Aps Protein C or activated protein C-like molecules
EP1436627A2 (de) * 2001-10-05 2004-07-14 Novozymes A/S Kit zur vorhersage der bindung eines spezifischen antikörpers an ein potentielles immunogen und screening-verfahren
SI1499719T1 (sl) 2002-04-30 2011-03-31 Bayer Healthcare Llc Polipeptidne variante faktorja VII ali VIIa
PL212139B1 (pl) * 2002-05-16 2012-08-31 Alk Abello As Zrekombinowany alergen, zastosowanie zrekombinowanego alergenu, kompozycja zawierająca dwa lub więcej wariantów zrekombinowanych zmutowanych alergenów, zastosowanie takiej kompozycji, kompozycja farmaceutyczna zawierająca zrekombinowany alergen lub wymienioną kompozycję, zastosowanie zrekombinowanego alergenu, kompozycji lub kompozycji farmaceutycznej, sposób przygotowania kompozycji farmaceutycznej, sposób przygotowania zrekombinowanego alergenu, sposób przygotowania biblioteki zrekombinowanego alergenu, sekwencja DNA kodująca zrekombinowany alergen, wektor ekspresyjny obejmujący wymienione DNA, komórka gospodarza zawierająca taki wektor ekspresyjny, sposób produkcji zrekombinowanego mutanta alergenu, oraz oznaczenie diagnostyczne do oceny odpowiedniości, bezpieczeństwa lub wyniku terapii
ATE494368T1 (de) 2002-10-01 2011-01-15 Novozymes As Polypeptide der gh-61-familie
EP2500423B1 (de) * 2003-02-26 2015-06-17 Danisco US Inc. Amylasen, die eine veränderte immunogene Reaktion bewirken, und Verfahren zu ihrer Herstellung und Verwendung
EP1597363B1 (de) * 2003-02-26 2015-07-15 Danisco US Inc. Amylasen, die eine veränderte immunogene reaktion bewirken, und verfahren zu ihrer herstellung und verwendung
DK2085470T3 (da) 2003-03-20 2012-08-06 Bayer Healthcare Llc FVII- eller FVIIa-varianter
CN1791672A (zh) * 2003-03-21 2006-06-21 诺和酶股份有限公司 使用基于jp170三维结构的蛋白质建模修饰枯草杆菌酶
US7727756B2 (en) 2003-03-21 2010-06-01 Novozymes A/S Subtilases
WO2004111224A1 (en) 2003-06-19 2004-12-23 Novozymes A/S Improved proteases and methods for producing them
CN1839203B (zh) 2003-06-19 2011-11-16 拜耳医药保健有限公司 因子VII或VIIa的GLA结构域变体
EP1639106B1 (de) 2003-06-19 2010-05-26 Novozymes A/S Proteasen
BRPI0414959A (pt) 2003-10-10 2006-11-07 Novozymes As variante de uma protease precursora, sequência de ácido nucleico isolado, construção de ácido nucleico, vetor de expressão e célula hospedeira recombinantes, métodos para produzir a variante de protease, para melhorar o valor nutricional de uma ração animal, e para tratar proteìnas, planta transgênica, ou parte da planta, animal transgênico, não humano, ou produtos, ou elementos deste, aditivo e composição de ração animal, uso da variante de protease e/ou da composição, protease, e, estrutura 3d
EP1709165B1 (de) 2004-01-06 2014-04-23 Novozymes A/S Polypeptide von alicyclobacillus
US7824896B2 (en) 2004-04-02 2010-11-02 Novozymes A/S Subtilase variants having altered lmmunogenicity
JP5623691B2 (ja) 2004-06-21 2014-11-12 ノボザイムスアクティーゼルスカブ プロテアーゼ
AR050895A1 (es) 2004-10-04 2006-11-29 Novozymes As Polipeptidos que tienen actividad de fitasa y polinucleotidos que los codifican
ES2614744T3 (es) 2004-10-04 2017-06-01 Novozymes A/S Polipéptidos con actividad de fitasa y polinucleótidos que codifican los mismos
US8119387B2 (en) 2005-08-16 2012-02-21 Novozymes A/S Polypeptides of strain Bacillus sp. P203
EP1998793A1 (de) 2006-03-22 2008-12-10 Novozymes A/S Verwendung von polypeptiden mit antimikrobieller wirkung
ES2531434T3 (es) 2006-04-04 2015-03-16 Novozymes A/S Variantes de fitasa
MX2009006597A (es) 2006-12-21 2009-07-02 Novozymes As Variantes de lipasa para uso farmaceutico.
US8221743B2 (en) 2006-12-22 2012-07-17 Novozymes A/S Use of polypeptides against diseases caused by protozoans
DK2129781T3 (da) 2007-03-26 2014-03-31 Novozymes As Hafnia-phytase
JP5056193B2 (ja) * 2007-06-21 2012-10-24 味の素株式会社 畜肉加工食品又は水産加工食品の製造方法及び畜肉加工食品又は水産加工食品改質用の酵素製剤
ES2544645T3 (es) 2008-09-26 2015-09-02 Novozymes A/S Variantes de fitasa de Hafnia
JP5230397B2 (ja) * 2008-12-18 2013-07-10 独立行政法人科学技術振興機構 抗膜貫通型タンパク質抗体の抗原結合部位を決定する方法
US9526768B2 (en) 2014-11-13 2016-12-27 Jennifer Mai Compositions for the treatment of cancer
CN108690841B (zh) * 2018-02-08 2021-10-01 河南科技学院 一种mPEG-Mal5000修饰β-淀粉酶的方法
EP4196575A1 (de) 2020-08-13 2023-06-21 Novozymes A/S Phytasevarianten und polynukleotide zur codierung davon

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Publication number Priority date Publication date Assignee Title
US4732863A (en) * 1984-12-31 1988-03-22 University Of New Mexico PEG-modified antibody with reduced affinity for cell surface Fc receptors
US5530101A (en) * 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
CA2331936C (en) 1990-12-05 2007-07-31 Novozymes A/S Proteins with changed epitopes and methods for the production thereof
CZ239694A3 (en) * 1992-04-01 1995-07-12 Merck & Co Inc Recombinant human antibody against hiv, cassette for expression, host cell and a pharmaceutical preparation against hiv
JP3475221B2 (ja) * 1994-09-05 2003-12-08 明治乳業株式会社 免疫原性が低下された変異体タンパク質
JPH08289790A (ja) * 1995-01-06 1996-11-05 Leuven Res & Dev Vzw 新規なスタフィロキナーゼ誘導体
CA2270593C (en) 1996-11-04 2005-06-07 Novo Nordisk A/S Subtilase variants and compositions
CA2271243A1 (en) 1996-11-08 1998-05-14 Radha Krishna Vakkalanka Diagnostic methods using cd40 ligand assay
AU743647B2 (en) * 1998-01-31 2002-01-31 Mt. Sinai School Of Medicine Of New York University Methods and reagents for decreasing allergic reactions

Also Published As

Publication number Publication date
CN1325404A (zh) 2001-12-05
ES2220114T3 (es) 2004-12-01
EP1277762A2 (de) 2003-01-22
ATE390441T1 (de) 2008-04-15
WO2000026230A8 (en) 2000-07-20
CA2348938A1 (en) 2000-05-11
DE69916306D1 (de) 2004-05-13
DE69916306T2 (de) 2005-05-04
EP1277762A3 (de) 2003-04-09
JP2003500003A (ja) 2003-01-07
EP1124843B1 (de) 2004-04-07
AU6078799A (en) 2000-05-22
EP1124843A1 (de) 2001-08-22
CN1206237C (zh) 2005-06-15
AU776534B2 (en) 2004-09-16
NZ511291A (en) 2003-08-29
EP1277762B1 (de) 2008-03-26
WO2000026230A1 (en) 2000-05-11
DE69938435D1 (de) 2008-05-08

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