ATE390441T1 - Niedrigallergene proteinvarianten - Google Patents

Niedrigallergene proteinvarianten

Info

Publication number
ATE390441T1
ATE390441T1 AT02020745T AT02020745T ATE390441T1 AT E390441 T1 ATE390441 T1 AT E390441T1 AT 02020745 T AT02020745 T AT 02020745T AT 02020745 T AT02020745 T AT 02020745T AT E390441 T1 ATE390441 T1 AT E390441T1
Authority
AT
Austria
Prior art keywords
protein
parent protein
immunogenicity
low
parent
Prior art date
Application number
AT02020745T
Other languages
English (en)
Inventor
Erwin Ludo Roggen
Arne Agerlin Olsen
Steffen Ernst
Original Assignee
Novozymes As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27221271&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE390441(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novozymes As filed Critical Novozymes As
Application granted granted Critical
Publication of ATE390441T1 publication Critical patent/ATE390441T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/02—Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only microorganisms or vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0055—Oxidoreductases (1.) acting on diphenols and related substances as donors (1.10)
    • C12N9/0057—Oxidoreductases (1.) acting on diphenols and related substances as donors (1.10) with oxygen as acceptor (1.10.3)
    • C12N9/0061—Laccase (1.10.3.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2405—Glucanases
    • C12N9/2408—Glucanases acting on alpha -1,4-glucosidic bonds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2405—Glucanases
    • C12N9/2408—Glucanases acting on alpha -1,4-glucosidic bonds
    • C12N9/2411—Amylases
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • C12N9/54—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea bacteria being Bacillus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y110/00—Oxidoreductases acting on diphenols and related substances as donors (1.10)
    • C12Y110/03—Oxidoreductases acting on diphenols and related substances as donors (1.10) with an oxygen as acceptor (1.10.3)
    • C12Y110/03002—Laccase (1.10.3.2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Virology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AT02020745T 1998-10-30 1999-10-12 Niedrigallergene proteinvarianten ATE390441T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA199801402 1998-10-30
DKPA199801645 1998-11-25
DKPA199901417 1999-10-04

Publications (1)

Publication Number Publication Date
ATE390441T1 true ATE390441T1 (de) 2008-04-15

Family

ID=27221271

Family Applications (2)

Application Number Title Priority Date Filing Date
AT99947260T ATE263778T1 (de) 1998-10-30 1999-10-12 Niedrigallergene proteinvarianten
AT02020745T ATE390441T1 (de) 1998-10-30 1999-10-12 Niedrigallergene proteinvarianten

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT99947260T ATE263778T1 (de) 1998-10-30 1999-10-12 Niedrigallergene proteinvarianten

Country Status (10)

Country Link
EP (2) EP1124843B1 (de)
JP (1) JP2003500003A (de)
CN (1) CN1206237C (de)
AT (2) ATE263778T1 (de)
AU (1) AU776534B2 (de)
CA (1) CA2348938A1 (de)
DE (2) DE69916306T2 (de)
ES (1) ES2220114T3 (de)
NZ (1) NZ511291A (de)
WO (1) WO2000026230A1 (de)

Families Citing this family (43)

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Publication number Priority date Publication date Assignee Title
US6747003B1 (en) 1997-10-23 2004-06-08 Regents Of The University Of Minnesota Modified vitamin K-dependent polypeptides
WO2003066847A2 (en) 2002-02-08 2003-08-14 Novozymes A/S Phytase variants
US6835550B1 (en) * 1998-04-15 2004-12-28 Genencor International, Inc. Mutant proteins having lower allergenic response in humans and methods for constructing, identifying and producing such proteins
WO2001004287A1 (en) * 1999-07-07 2001-01-18 Maxygen Aps A method for preparing modified polypeptides
CA2394377A1 (en) * 1999-12-09 2001-05-10 Novozymes A/S High throughput screening (hts) assays for protein variants with reducedantibody binding capacity
PL206148B1 (pl) 2000-02-11 2010-07-30 Bayer HealthCare LLCBayer HealthCare LLC Koniugat polipeptydowy, polipeptyd, sekwencja nukleotydowa, wektor ekspresyjny, komórka gospodarz, sposób wytwarzania koniugatu polipeptydowego, środek farmaceutyczny i zastosowanie koniugatu polipeptydowego
EP2258853B1 (de) * 2000-04-28 2016-06-08 Novozymes A/S Variante eines lipolytischen Enzyms
US7220837B1 (en) 2000-04-28 2007-05-22 Regents Of The University Of Minnesota Modified vitamin K-dependent polypeptides
US7812132B2 (en) 2000-04-28 2010-10-12 Regents Of The University Of Minnesota Modified vitamin K-dependent polypeptides
AU2001265836A1 (en) * 2000-06-21 2002-01-02 Novozymes A/S Method for genome mining for secreted protein genes
US20030211094A1 (en) 2001-06-26 2003-11-13 Nelsestuen Gary L. High molecular weight derivatives of vitamin k-dependent polypeptides
EP1340085B1 (de) * 2000-10-17 2008-07-30 Besst-Test Aps Test zum direkten nachweisen einer biologischen zelle in einer körperflüssigkeitsprobe
US6933367B2 (en) 2000-10-18 2005-08-23 Maxygen Aps Protein C or activated protein C-like molecules
CA2462651A1 (en) * 2001-10-05 2003-04-17 Novozymes A/S Kit for predicting binding of a specific antibody to a potential immunogen and method of screening
RU2004134726A (ru) 2002-04-30 2005-06-10 Максиджен Холдингз Лтд. (Ky) Варианты полипептида фактора vii или viia
EP1504089A2 (de) * 2002-05-16 2005-02-09 Alk Abell A/S Allergenmutanten
ATE494368T1 (de) 2002-10-01 2011-01-15 Novozymes As Polypeptide der gh-61-familie
EP2500423B1 (de) * 2003-02-26 2015-06-17 Danisco US Inc. Amylasen, die eine veränderte immunogene Reaktion bewirken, und Verfahren zu ihrer Herstellung und Verwendung
AU2003213273A1 (en) * 2003-02-26 2004-09-28 Genencor International, Inc. Amylases producing an altered immunogenic response and methods of making and using the same
CA2519873C (en) 2003-03-20 2012-12-18 Maxygen Holdings Ltd. Fvii or fviia variants
WO2004083362A2 (en) * 2003-03-21 2004-09-30 Novozymes A/S Modification of subtilases using protein modelling based on the jp170 three-dimensional structure
US7727756B2 (en) 2003-03-21 2010-06-01 Novozymes A/S Subtilases
ATE458057T1 (de) 2003-06-19 2010-03-15 Bayer Healthcare Llc Varianten der faktor-vii- oder -viia-gla-domäne
US20060236414A1 (en) 2003-06-19 2006-10-19 Novozymes A/S Proteases and methods for producing them
ES2346654T3 (es) 2003-06-19 2010-10-19 Novozymes A/S Proteasas.
CN1867668A (zh) 2003-10-10 2006-11-22 诺维信公司 蛋白酶变体
WO2005066339A2 (en) 2004-01-06 2005-07-21 Novozymes A/S Polypeptides of alicyclobacillus sp.
EP1735433B1 (de) 2004-04-02 2010-12-08 Novozymes A/S Subtilasevarianten mit veränderter immunogenität
EP1766001B1 (de) 2004-06-21 2012-01-11 Novozymes A/S Nocardiopsis-proteasen
AR050895A1 (es) 2004-10-04 2006-11-29 Novozymes As Polipeptidos que tienen actividad de fitasa y polinucleotidos que los codifican
CN103224918B (zh) 2004-10-04 2015-08-26 诺维信公司 具有肌醇六磷酸酶活性的多肽和编码它的多核苷酸
WO2007019859A2 (en) 2005-08-16 2007-02-22 Novozymes A/S Polypeptides of strain bacillus sp. p203
WO2007107573A1 (en) 2006-03-22 2007-09-27 Novozymes A/S Use of polypeptides having antimicrobial activity
PL2365064T3 (pl) 2006-04-04 2015-05-29 Novozymes As Warianty fitazy
KR20090101930A (ko) 2006-12-21 2009-09-29 노보자임스 에이/에스 약학적 사용을 위한 리파아제 변형체
US8221743B2 (en) 2006-12-22 2012-07-17 Novozymes A/S Use of polypeptides against diseases caused by protozoans
PL2129781T3 (pl) 2007-03-26 2014-07-31 Novozymes As Fitaza z Hafnia
JP5056193B2 (ja) * 2007-06-21 2012-10-24 味の素株式会社 畜肉加工食品又は水産加工食品の製造方法及び畜肉加工食品又は水産加工食品改質用の酵素製剤
EP2650364B1 (de) 2008-09-26 2015-05-20 Novozymes A/S Hafnia-Phytasevarianten
JP5230397B2 (ja) * 2008-12-18 2013-07-10 独立行政法人科学技術振興機構 抗膜貫通型タンパク質抗体の抗原結合部位を決定する方法
US9526768B2 (en) 2014-11-13 2016-12-27 Jennifer Mai Compositions for the treatment of cancer
CN108690841B (zh) * 2018-02-08 2021-10-01 河南科技学院 一种mPEG-Mal5000修饰β-淀粉酶的方法
CA3189083A1 (en) 2020-08-13 2022-02-17 Novozymes A/S Phytase variants and polynucleotides encoding same

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US4732863A (en) * 1984-12-31 1988-03-22 University Of New Mexico PEG-modified antibody with reduced affinity for cell surface Fc receptors
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KR100237968B1 (ko) * 1990-12-05 2000-01-15 한센 핀 베네드 변화된 에피토프를 지닌 단백질 및 그 제조방법
RU94045907A (ru) * 1992-04-01 1996-11-10 Мерк Энд Ко. Вич-антитела человека или их фрагменты, экспрессионные кассеты, клетки-хозяева, фармацевтические композиции, способ защиты
JP3475221B2 (ja) * 1994-09-05 2003-12-08 明治乳業株式会社 免疫原性が低下された変異体タンパク質
JPH08289790A (ja) * 1995-01-06 1996-11-05 Leuven Res & Dev Vzw 新規なスタフィロキナーゼ誘導体
JP4044143B2 (ja) 1996-11-04 2008-02-06 ノボザイムス アクティーゼルスカブ ズブチラーゼ変異体及び組成物
US6117642A (en) 1996-11-08 2000-09-12 New York Society For The Relief Of The Ruptured And Crippled Maintaining The Hospital For Special Surgery Methods of determining disease activity in SLE patients by correlating the level of soluble CD40 ligand
JP2002501748A (ja) * 1998-01-31 2002-01-22 ユニバーシティ オブ アーカンソー アレルギー反応を減少させるための方法および試薬

Also Published As

Publication number Publication date
AU6078799A (en) 2000-05-22
WO2000026230A1 (en) 2000-05-11
EP1124843A1 (de) 2001-08-22
EP1277762A2 (de) 2003-01-22
DE69938435D1 (de) 2008-05-08
ATE263778T1 (de) 2004-04-15
AU776534B2 (en) 2004-09-16
CN1206237C (zh) 2005-06-15
JP2003500003A (ja) 2003-01-07
NZ511291A (en) 2003-08-29
EP1124843B1 (de) 2004-04-07
DE69916306T2 (de) 2005-05-04
CN1325404A (zh) 2001-12-05
WO2000026230A8 (en) 2000-07-20
DE69916306D1 (de) 2004-05-13
ES2220114T3 (es) 2004-12-01
EP1277762B1 (de) 2008-03-26
CA2348938A1 (en) 2000-05-11
EP1277762A3 (de) 2003-04-09

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