JP2003511413A5 - - Google Patents
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- Publication number
- JP2003511413A5 JP2003511413A5 JP2001529439A JP2001529439A JP2003511413A5 JP 2003511413 A5 JP2003511413 A5 JP 2003511413A5 JP 2001529439 A JP2001529439 A JP 2001529439A JP 2001529439 A JP2001529439 A JP 2001529439A JP 2003511413 A5 JP2003511413 A5 JP 2003511413A5
- Authority
- JP
- Japan
- Prior art keywords
- carnitine
- osmotic agent
- solution
- concentration
- peritoneal dialysis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002357 osmotic agent Substances 0.000 description 25
- PHIQHXFUZVPYII-ZCFIWIBFSA-N (R)-carnitine Chemical compound C[N+](C)(C)C[C@H](O)CC([O-])=O PHIQHXFUZVPYII-ZCFIWIBFSA-N 0.000 description 17
- 238000000502 dialysis Methods 0.000 description 13
- 125000001589 carboacyl group Chemical group 0.000 description 9
- 150000003839 salts Chemical class 0.000 description 6
- 239000000203 mixture Substances 0.000 description 5
- 239000002253 acid Substances 0.000 description 4
- 125000001931 aliphatic group Chemical group 0.000 description 4
- 229940024606 amino acid Drugs 0.000 description 4
- 150000001413 amino acids Chemical class 0.000 description 4
- 125000004432 carbon atom Chemical group C* 0.000 description 4
- RDHQFKQIGNGIED-MRVPVSSYSA-N O-acetyl-L-carnitine Chemical compound CC(=O)O[C@H](CC([O-])=O)C[N+](C)(C)C RDHQFKQIGNGIED-MRVPVSSYSA-N 0.000 description 3
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- 239000008103 glucose Substances 0.000 description 2
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 2
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 1
- XOMRRQXKHMYMOC-OAQYLSRUSA-N O-palmitoyl-L-carnitine Chemical compound CCCCCCCCCCCCCCCC(=O)O[C@H](CC([O-])=O)C[N+](C)(C)C XOMRRQXKHMYMOC-OAQYLSRUSA-N 0.000 description 1
- 229940009098 aspartate Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/IT1999/000317 WO2001026649A1 (en) | 1999-10-11 | 1999-10-11 | Use of l-carnitine and its alkanoyl derivatives as osmotic agents in solutions for medical use |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2003511413A JP2003511413A (ja) | 2003-03-25 |
| JP2003511413A5 true JP2003511413A5 (enExample) | 2006-11-30 |
| JP4638106B2 JP4638106B2 (ja) | 2011-02-23 |
Family
ID=11333127
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001529439A Expired - Fee Related JP4638106B2 (ja) | 1999-10-11 | 1999-10-11 | 医薬的使用のための溶液中における浸透圧剤としての、ｌ−カルニチンおよびそのアルカノイル誘導体の使用 |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US6822002B1 (enExample) |
| EP (1) | EP1220670B1 (enExample) |
| JP (1) | JP4638106B2 (enExample) |
| KR (1) | KR100642731B1 (enExample) |
| AT (1) | ATE336243T1 (enExample) |
| AU (1) | AU1073400A (enExample) |
| CA (1) | CA2386826C (enExample) |
| CY (1) | CY1106203T1 (enExample) |
| CZ (1) | CZ303870B6 (enExample) |
| DE (1) | DE69932860T2 (enExample) |
| DK (1) | DK1220670T3 (enExample) |
| ES (1) | ES2270620T3 (enExample) |
| HK (1) | HK1046090B (enExample) |
| HU (1) | HUP0203441A3 (enExample) |
| MX (1) | MXPA02003635A (enExample) |
| PL (1) | PL213131B1 (enExample) |
| PT (1) | PT1220670E (enExample) |
| SI (1) | SI1220670T1 (enExample) |
| SK (1) | SK288072B6 (enExample) |
| WO (1) | WO2001026649A1 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6770148B1 (en) | 1998-12-04 | 2004-08-03 | Baxter International Inc. | Peritoneal dialysis solution containing modified icodextrins |
| ITRM20010337A1 (it) * | 2001-06-14 | 2002-12-16 | Sigma Tau Ind Farmaceuti | Soluzione per la conservazione e perfuzione di organi in attesa che vengano trapiantati. |
| US8173618B2 (en) * | 2003-07-25 | 2012-05-08 | University Of Massachusetts | Formulations for reducing neuronal degeneration |
| US7053059B2 (en) | 2003-07-25 | 2006-05-30 | Baxter International Inc. | Dialysis solutions with reduced levels of glucose degradation products |
| ITRM20040346A1 (it) * | 2004-07-13 | 2004-10-13 | Sigma Tau Ind Farmaceuti | Uso della l-carnitina per il trattamento di patologie cardiovascolari. |
| JP2006075195A (ja) * | 2004-09-07 | 2006-03-23 | Jms Co Ltd | Ｌカルニチン含有腹膜透析液 |
| TWI388318B (zh) * | 2005-03-10 | 2013-03-11 | Sigma Tau Ind Farmaceuti | 具有改良之生物相容性的含有肉毒鹼之腹膜透析溶液 |
| US20070087975A1 (en) * | 2005-10-17 | 2007-04-19 | Sigma-Tau Industrie Farmaceutiche Riunite Spa | Compound useful for the prevention and treatment of left ventricular hypertrophy in dialysed patients |
| EP1979020A4 (en) * | 2006-01-30 | 2011-03-30 | Univ California | PERITONEAL DIALYSIS PROCESS AND DEVICE |
| US8876753B2 (en) | 2006-01-30 | 2014-11-04 | The Regents Of The University Of California | Peritoneal dialysis methods and apparatus |
| US8597640B2 (en) * | 2007-10-31 | 2013-12-03 | University Of Massachusetts Lowell | Over-the-counter vitamin/nutriceutical formulation that provides neuroprotection and maintains or improves cognitive performance in alzheimer's disease and normal aging |
| ES2396650B2 (es) * | 2011-07-21 | 2013-07-16 | Universidad Complutense De Madrid | Uso de una composición en la elaboración de una solución de diálisis para el tratamiento de las enfermedades cerebrovasculares mediante diálisis peritoneal. |
| TWI454287B (zh) * | 2012-11-21 | 2014-10-01 | Taipei Veteran General Hospital | 治療纖維化之透析液 |
| US9539411B2 (en) | 2013-03-13 | 2017-01-10 | W. L. Gore & Associates, Inc. | Deconstructable endoluminal devices and related systems and methods |
| CN103330715B (zh) * | 2013-07-01 | 2015-09-02 | 华仁药业股份有限公司 | 一种抗腹膜纤维化的腹膜透析液 |
| CN103463081B (zh) * | 2013-09-27 | 2015-10-21 | 华仁药业股份有限公司 | 腹膜透析液 |
| DE102015014699A1 (de) * | 2015-11-13 | 2017-05-18 | Fresenius Medical Care Deutschland Gmbh | Dialyselösung mit wenigstens einem Osmotikum |
| EP3912656A1 (en) | 2020-05-19 | 2021-11-24 | CoreQuest Sagl | Peritoneal dialysis solution |
| EP4029507A1 (en) | 2021-01-19 | 2022-07-20 | Iperboreal Pharma Srl | Peritoneal dialysis solution for hypertensive subjects |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1156741B (it) | 1978-05-15 | 1987-02-04 | Sigma Tau Ind Farmaceuti | Applicazione terapeutica della carnitina e di alcuni derivati acilati della carnitina nell'emodialisi |
| IT1120033B (it) | 1979-10-05 | 1986-03-19 | Sigma Tau Ind Farmaceuti | Composizione farmaceutica comprendente-carnitina adatta per l'alimentazione parenterale |
| CH664374A5 (de) * | 1985-02-27 | 1988-02-29 | Lonza Ag | Verfahren zur herstellung von l-carnitin auf mikrobiologischem weg. |
| JPH04320145A (ja) * | 1991-04-19 | 1992-11-10 | Ricoh Co Ltd | ファクシミリ装置 |
| IT1261695B (it) * | 1993-06-02 | 1996-05-29 | Sigma Tau Ind Farmaceuti | Impiego di l-carnitina e alcanoil l-carnitine nella conservazione del sangue per trasfusioni e soluzioni stabilizzatrici che le contengono. |
| IT1283137B1 (it) | 1996-07-09 | 1998-04-07 | Bieffe Medital Spa | Agenti osmotici alternativi e relative soluzioni per dialisi peritoneale |
| JPH1094598A (ja) | 1996-07-31 | 1998-04-14 | Baxter Internatl Inc | 腹膜透析液 |
| US5973004A (en) * | 1997-04-04 | 1999-10-26 | Howard; James R. | L-carnitine, acetyl-L-carnitine, and pantothenic acid or ubiquinone, combined for prevention and treatment of syndromes related to ineffective energy metabolism |
| US6482585B2 (en) * | 1997-04-16 | 2002-11-19 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Storage and maintenance of blood products including red blood cells and platelets |
| GB9714218D0 (en) | 1997-07-04 | 1997-09-10 | Allied Therapeutics Ltd | Peritoneal dialysis fluid |
| JPH1149671A (ja) | 1997-08-06 | 1999-02-23 | Baxter Internatl Inc | 腹膜透析液 |
| US6537976B1 (en) * | 1997-08-07 | 2003-03-25 | Ajay Gupta | Dialysis solutions containing water soluble vitamins and nutrients |
| JPH1171286A (ja) | 1997-08-29 | 1999-03-16 | Terumo Corp | 腹膜透析液 |
| JPH1171273A (ja) | 1997-08-29 | 1999-03-16 | Terumo Corp | 腹膜透析液 |
| AU2557899A (en) * | 1998-01-15 | 1999-08-02 | Edward Hirschberg | Methods of infusing phytochemicals, nutraceuticals, and other compositions into food products |
-
1999
- 1999-10-11 KR KR1020027004552A patent/KR100642731B1/ko not_active Expired - Fee Related
- 1999-10-11 US US10/110,304 patent/US6822002B1/en not_active Expired - Lifetime
- 1999-10-11 JP JP2001529439A patent/JP4638106B2/ja not_active Expired - Fee Related
- 1999-10-11 MX MXPA02003635A patent/MXPA02003635A/es not_active IP Right Cessation
- 1999-10-11 SK SK443-2002A patent/SK288072B6/sk not_active IP Right Cessation
- 1999-10-11 ES ES99954329T patent/ES2270620T3/es not_active Expired - Lifetime
- 1999-10-11 CA CA2386826A patent/CA2386826C/en not_active Expired - Fee Related
- 1999-10-11 CZ CZ20021063A patent/CZ303870B6/cs not_active IP Right Cessation
- 1999-10-11 PL PL354414A patent/PL213131B1/pl unknown
- 1999-10-11 AU AU10734/00A patent/AU1073400A/en not_active Abandoned
- 1999-10-11 SI SI9930921T patent/SI1220670T1/sl unknown
- 1999-10-11 AT AT99954329T patent/ATE336243T1/de active
- 1999-10-11 EP EP99954329A patent/EP1220670B1/en not_active Expired - Lifetime
- 1999-10-11 HU HU0203441A patent/HUP0203441A3/hu unknown
- 1999-10-11 PT PT99954329T patent/PT1220670E/pt unknown
- 1999-10-11 DK DK99954329T patent/DK1220670T3/da active
- 1999-10-11 HK HK02106588.3A patent/HK1046090B/en not_active IP Right Cessation
- 1999-10-11 DE DE69932860T patent/DE69932860T2/de not_active Expired - Lifetime
- 1999-10-11 WO PCT/IT1999/000317 patent/WO2001026649A1/en not_active Ceased
-
2004
- 2004-10-12 US US10/960,938 patent/US7932291B2/en not_active Expired - Fee Related
-
2006
- 2006-10-16 CY CY20061101485T patent/CY1106203T1/el unknown
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