KR100642731B1 - 의료용 용액에서 삼투제로서 ｌ-카르니틴 및 그의알카노일 유도체의 용도 - Google Patents

의료용 용액에서 삼투제로서 ｌ-카르니틴 및 그의알카노일 유도체의 용도 Download PDF

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Publication number
KR100642731B1
KR100642731B1 KR1020027004552A KR20027004552A KR100642731B1 KR 100642731 B1 KR100642731 B1 KR 100642731B1 KR 1020027004552 A KR1020027004552 A KR 1020027004552A KR 20027004552 A KR20027004552 A KR 20027004552A KR 100642731 B1 KR100642731 B1 KR 100642731B1
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KR
South Korea
Prior art keywords
carnitine
peritoneal dialysis
solution
osmotic agent
concentration
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Expired - Fee Related
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KR1020027004552A
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English (en)
Korean (ko)
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KR20020038809A (ko
Inventor
아듀이니아듀이노
Original Assignee
시그마타우 인두스트리에 파르마슈티케 리우니테 에스.피.에이.
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Application filed by 시그마타우 인두스트리에 파르마슈티케 리우니테 에스.피.에이. filed Critical 시그마타우 인두스트리에 파르마슈티케 리우니테 에스.피.에이.
Publication of KR20020038809A publication Critical patent/KR20020038809A/ko
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Urology & Nephrology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Emergency Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • External Artificial Organs (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
KR1020027004552A 1999-10-11 1999-10-11 의료용 용액에서 삼투제로서 ｌ-카르니틴 및 그의알카노일 유도체의 용도 Expired - Fee Related KR100642731B1 (ko)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IT1999/000317 WO2001026649A1 (en) 1999-10-11 1999-10-11 Use of l-carnitine and its alkanoyl derivatives as osmotic agents in solutions for medical use

Publications (2)

Publication Number Publication Date
KR20020038809A KR20020038809A (ko) 2002-05-23
KR100642731B1 true KR100642731B1 (ko) 2006-11-03

Family

ID=11333127

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020027004552A Expired - Fee Related KR100642731B1 (ko) 1999-10-11 1999-10-11 의료용 용액에서 삼투제로서 ｌ-카르니틴 및 그의알카노일 유도체의 용도

Country Status (20)

Country Link
US (2) US6822002B1 (enExample)
EP (1) EP1220670B1 (enExample)
JP (1) JP4638106B2 (enExample)
KR (1) KR100642731B1 (enExample)
AT (1) ATE336243T1 (enExample)
AU (1) AU1073400A (enExample)
CA (1) CA2386826C (enExample)
CY (1) CY1106203T1 (enExample)
CZ (1) CZ303870B6 (enExample)
DE (1) DE69932860T2 (enExample)
DK (1) DK1220670T3 (enExample)
ES (1) ES2270620T3 (enExample)
HK (1) HK1046090B (enExample)
HU (1) HUP0203441A3 (enExample)
MX (1) MXPA02003635A (enExample)
PL (1) PL213131B1 (enExample)
PT (1) PT1220670E (enExample)
SI (1) SI1220670T1 (enExample)
SK (1) SK288072B6 (enExample)
WO (1) WO2001026649A1 (enExample)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6770148B1 (en) 1998-12-04 2004-08-03 Baxter International Inc. Peritoneal dialysis solution containing modified icodextrins
ITRM20010337A1 (it) * 2001-06-14 2002-12-16 Sigma Tau Ind Farmaceuti Soluzione per la conservazione e perfuzione di organi in attesa che vengano trapiantati.
US7053059B2 (en) 2003-07-25 2006-05-30 Baxter International Inc. Dialysis solutions with reduced levels of glucose degradation products
US8173618B2 (en) * 2003-07-25 2012-05-08 University Of Massachusetts Formulations for reducing neuronal degeneration
ITRM20040346A1 (it) 2004-07-13 2004-10-13 Sigma Tau Ind Farmaceuti Uso della l-carnitina per il trattamento di patologie cardiovascolari.
JP2006075195A (ja) * 2004-09-07 2006-03-23 Jms Co Ltd Ｌカルニチン含有腹膜透析液
TWI388318B (zh) * 2005-03-10 2013-03-11 Sigma Tau Ind Farmaceuti 具有改良之生物相容性的含有肉毒鹼之腹膜透析溶液
US20070087975A1 (en) * 2005-10-17 2007-04-19 Sigma-Tau Industrie Farmaceutiche Riunite Spa Compound useful for the prevention and treatment of left ventricular hypertrophy in dialysed patients
US8876753B2 (en) 2006-01-30 2014-11-04 The Regents Of The University Of California Peritoneal dialysis methods and apparatus
AU2007211317B2 (en) * 2006-01-30 2012-05-31 The Regents Of The University Of California Peritoneal dialysis methods and apparatus
US8597640B2 (en) * 2007-10-31 2013-12-03 University Of Massachusetts Lowell Over-the-counter vitamin/nutriceutical formulation that provides neuroprotection and maintains or improves cognitive performance in alzheimer's disease and normal aging
ES2396650B2 (es) * 2011-07-21 2013-07-16 Universidad Complutense De Madrid Uso de una composición en la elaboración de una solución de diálisis para el tratamiento de las enfermedades cerebrovasculares mediante diálisis peritoneal.
TWI454287B (zh) * 2012-11-21 2014-10-01 Taipei Veteran General Hospital 治療纖維化之透析液
US9539411B2 (en) 2013-03-13 2017-01-10 W. L. Gore & Associates, Inc. Deconstructable endoluminal devices and related systems and methods
CN103330715B (zh) * 2013-07-01 2015-09-02 华仁药业股份有限公司 一种抗腹膜纤维化的腹膜透析液
CN103463081B (zh) * 2013-09-27 2015-10-21 华仁药业股份有限公司 腹膜透析液
DE102015014699A1 (de) * 2015-11-13 2017-05-18 Fresenius Medical Care Deutschland Gmbh Dialyselösung mit wenigstens einem Osmotikum
EP3912656A1 (en) * 2020-05-19 2021-11-24 CoreQuest Sagl Peritoneal dialysis solution
EP4029507A1 (en) 2021-01-19 2022-07-20 Iperboreal Pharma Srl Peritoneal dialysis solution for hypertensive subjects

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4320145A (en) * 1979-10-05 1982-03-16 Claudio Cavazza Pharmaceutical composition for parenteral nutrition comprising L-carnitine or acyl L-carnitines
JPH04320145A (ja) * 1991-04-19 1992-11-10 Ricoh Co Ltd ファクシミリ装置

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1156741B (it) * 1978-05-15 1987-02-04 Sigma Tau Ind Farmaceuti Applicazione terapeutica della carnitina e di alcuni derivati acilati della carnitina nell'emodialisi
CH664374A5 (de) * 1985-02-27 1988-02-29 Lonza Ag Verfahren zur herstellung von l-carnitin auf mikrobiologischem weg.
IT1261695B (it) 1993-06-02 1996-05-29 Sigma Tau Ind Farmaceuti Impiego di l-carnitina e alcanoil l-carnitine nella conservazione del sangue per trasfusioni e soluzioni stabilizzatrici che le contengono.
IT1283137B1 (it) 1996-07-09 1998-04-07 Bieffe Medital Spa Agenti osmotici alternativi e relative soluzioni per dialisi peritoneale
JPH1094598A (ja) 1996-07-31 1998-04-14 Baxter Internatl Inc 腹膜透析液
US5973004A (en) * 1997-04-04 1999-10-26 Howard; James R. L-carnitine, acetyl-L-carnitine, and pantothenic acid or ubiquinone, combined for prevention and treatment of syndromes related to ineffective energy metabolism
US6482585B2 (en) * 1997-04-16 2002-11-19 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Storage and maintenance of blood products including red blood cells and platelets
GB9714218D0 (en) 1997-07-04 1997-09-10 Allied Therapeutics Ltd Peritoneal dialysis fluid
JPH1149671A (ja) 1997-08-06 1999-02-23 Baxter Internatl Inc 腹膜透析液
US6537976B1 (en) * 1997-08-07 2003-03-25 Ajay Gupta Dialysis solutions containing water soluble vitamins and nutrients
JPH1171286A (ja) 1997-08-29 1999-03-16 Terumo Corp 腹膜透析液
JPH1171273A (ja) 1997-08-29 1999-03-16 Terumo Corp 腹膜透析液
WO1999035917A1 (en) * 1998-01-15 1999-07-22 Edward Hirschberg Methods of infusing phytochemicals, nutraceuticals, and other compositions into food products

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4320145A (en) * 1979-10-05 1982-03-16 Claudio Cavazza Pharmaceutical composition for parenteral nutrition comprising L-carnitine or acyl L-carnitines
JPH04320145A (ja) * 1991-04-19 1992-11-10 Ricoh Co Ltd ファクシミリ装置

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
04320145

Also Published As

Publication number Publication date
DK1220670T3 (da) 2006-12-18
JP2003511413A (ja) 2003-03-25
SK288072B6 (sk) 2013-05-03
CY1106203T1 (el) 2011-06-08
JP4638106B2 (ja) 2011-02-23
HUP0203441A2 (hu) 2003-03-28
WO2001026649A1 (en) 2001-04-19
ES2270620T3 (es) 2007-04-01
CA2386826C (en) 2010-04-20
SI1220670T1 (sl) 2006-12-31
CA2386826A1 (en) 2001-04-19
CZ303870B6 (cs) 2013-06-05
US20050085542A1 (en) 2005-04-21
PL354414A1 (en) 2004-01-12
CZ20021063A3 (cs) 2002-08-14
PT1220670E (pt) 2006-10-31
HK1046090A1 (en) 2002-12-27
PL213131B1 (pl) 2013-01-31
HK1046090B (en) 2007-06-29
EP1220670A1 (en) 2002-07-10
US6822002B1 (en) 2004-11-23
DE69932860D1 (de) 2006-09-28
KR20020038809A (ko) 2002-05-23
MXPA02003635A (es) 2002-10-23
US7932291B2 (en) 2011-04-26
HUP0203441A3 (en) 2004-01-28
EP1220670B1 (en) 2006-08-16
DE69932860T2 (de) 2007-08-30
ATE336243T1 (de) 2006-09-15
SK4432002A3 (en) 2002-08-06
AU1073400A (en) 2001-04-23

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