JP2008532601A5 - - Google Patents
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- Publication number
- JP2008532601A5 JP2008532601A5 JP2008500161A JP2008500161A JP2008532601A5 JP 2008532601 A5 JP2008532601 A5 JP 2008532601A5 JP 2008500161 A JP2008500161 A JP 2008500161A JP 2008500161 A JP2008500161 A JP 2008500161A JP 2008532601 A5 JP2008532601 A5 JP 2008532601A5
- Authority
- JP
- Japan
- Prior art keywords
- solution
- acid
- meq
- glucose
- pyruvate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002253 acid Substances 0.000 claims 10
- 238000000502 dialysis Methods 0.000 claims 5
- PHIQHXFUZVPYII-ZCFIWIBFSA-N (R)-carnitine Chemical compound C[N+](C)(C)C[C@H](O)CC([O-])=O PHIQHXFUZVPYII-ZCFIWIBFSA-N 0.000 claims 4
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 4
- 239000008103 glucose Substances 0.000 claims 4
- 239000002357 osmotic agent Substances 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 3
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims 3
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims 3
- 239000000811 xylitol Substances 0.000 claims 3
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims 3
- 229960002675 xylitol Drugs 0.000 claims 3
- 235000010447 xylitol Nutrition 0.000 claims 3
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims 2
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 claims 2
- 125000001589 carboacyl group Chemical group 0.000 claims 2
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 claims 2
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 claims 2
- -1 pamoate Substances 0.000 claims 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- 229940095064 tartrate Drugs 0.000 claims 2
- 229930003231 vitamin Natural products 0.000 claims 2
- 239000011782 vitamin Substances 0.000 claims 2
- 229940088594 vitamin Drugs 0.000 claims 2
- 235000013343 vitamin Nutrition 0.000 claims 2
- NDVRKEKNSBMTAX-BTVCFUMJSA-N (2r,3s,4r,5r)-2,3,4,5,6-pentahydroxyhexanal;phosphoric acid Chemical compound OP(O)(O)=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O NDVRKEKNSBMTAX-BTVCFUMJSA-N 0.000 claims 1
- DYEQJABLISMNPH-UHFFFAOYSA-N 1,1-dihydroxypropan-2-one;2-oxopropanoic acid Chemical compound CC(=O)C(O)O.CC(=O)C(O)=O DYEQJABLISMNPH-UHFFFAOYSA-N 0.000 claims 1
- NUOVSUZZKIBUNY-UHFFFAOYSA-N 2,3-bis(2-oxopropanoyloxy)propyl 2-oxopropanoate Chemical compound CC(=O)C(=O)OCC(OC(=O)C(C)=O)COC(=O)C(C)=O NUOVSUZZKIBUNY-UHFFFAOYSA-N 0.000 claims 1
- QWJSAWXRUVVRLH-LREBCSMRSA-M 2-hydroxyethyl(trimethyl)azanium;(2r,3r)-2,3,4-trihydroxy-4-oxobutanoate Chemical compound C[N+](C)(C)CCO.OC(=O)[C@H](O)[C@@H](O)C([O-])=O QWJSAWXRUVVRLH-LREBCSMRSA-M 0.000 claims 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 claims 1
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 claims 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims 1
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 claims 1
- 229930091371 Fructose Natural products 0.000 claims 1
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 claims 1
- 239000005715 Fructose Substances 0.000 claims 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims 1
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 claims 1
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 claims 1
- 229910019142 PO4 Inorganic materials 0.000 claims 1
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 claims 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims 1
- JZRWCGZRTZMZEH-UHFFFAOYSA-N Thiamine Natural products CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N JZRWCGZRTZMZEH-UHFFFAOYSA-N 0.000 claims 1
- 229930003471 Vitamin B2 Natural products 0.000 claims 1
- LXNHXLLTXMVWPM-UHFFFAOYSA-N Vitamin B6 Natural products CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 claims 1
- 229940024606 amino acid Drugs 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 230000003510 anti-fibrotic effect Effects 0.000 claims 1
- 239000003963 antioxidant agent Substances 0.000 claims 1
- 229940009098 aspartate Drugs 0.000 claims 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims 1
- 239000011575 calcium Substances 0.000 claims 1
- 229910052791 calcium Inorganic materials 0.000 claims 1
- 229960004203 carnitine Drugs 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 150000001805 chlorine compounds Chemical group 0.000 claims 1
- 239000002934 diuretic Substances 0.000 claims 1
- 229940030606 diuretics Drugs 0.000 claims 1
- 235000019152 folic acid Nutrition 0.000 claims 1
- 239000011724 folic acid Substances 0.000 claims 1
- 229960000304 folic acid Drugs 0.000 claims 1
- 229930182830 galactose Natural products 0.000 claims 1
- 125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 claims 1
- 229940088597 hormone Drugs 0.000 claims 1
- 239000005556 hormone Substances 0.000 claims 1
- 239000011777 magnesium Substances 0.000 claims 1
- 229910052749 magnesium Inorganic materials 0.000 claims 1
- 229960005336 magnesium citrate Drugs 0.000 claims 1
- 235000002538 magnesium citrate Nutrition 0.000 claims 1
- 239000004337 magnesium citrate Substances 0.000 claims 1
- 229940091250 magnesium supplement Drugs 0.000 claims 1
- 229940095060 magnesium tartrate Drugs 0.000 claims 1
- MUZDLCBWNVUYIR-ZVGUSBNCSA-L magnesium;(2r,3r)-2,3-dihydroxybutanedioate Chemical compound [Mg+2].[O-]C(=O)[C@H](O)[C@@H](O)C([O-])=O MUZDLCBWNVUYIR-ZVGUSBNCSA-L 0.000 claims 1
- QUIOHQITLKCGNW-TYYBGVCCSA-L magnesium;(e)-but-2-enedioate Chemical compound [Mg+2].[O-]C(=O)\C=C\C([O-])=O QUIOHQITLKCGNW-TYYBGVCCSA-L 0.000 claims 1
- YZURQOBSFRVSEB-UHFFFAOYSA-L magnesium;2-aminoethanesulfonate Chemical compound [Mg+2].NCCS([O-])(=O)=O.NCCS([O-])(=O)=O YZURQOBSFRVSEB-UHFFFAOYSA-L 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- PXQPEWDEAKTCGB-UHFFFAOYSA-N orotic acid Chemical compound OC(=O)C1=CC(=O)NC(=O)N1 PXQPEWDEAKTCGB-UHFFFAOYSA-N 0.000 claims 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 1
- 239000010452 phosphate Substances 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- RADKZDMFGJYCBB-UHFFFAOYSA-N pyridoxal hydrochloride Natural products CC1=NC=C(CO)C(C=O)=C1O RADKZDMFGJYCBB-UHFFFAOYSA-N 0.000 claims 1
- ZUFQODAHGAHPFQ-UHFFFAOYSA-N pyridoxine hydrochloride Chemical compound Cl.CC1=NC=C(CO)C(CO)=C1O ZUFQODAHGAHPFQ-UHFFFAOYSA-N 0.000 claims 1
- 150000004728 pyruvic acid derivatives Chemical class 0.000 claims 1
- 229960002477 riboflavin Drugs 0.000 claims 1
- 239000011734 sodium Substances 0.000 claims 1
- 229910052708 sodium Inorganic materials 0.000 claims 1
- 239000000600 sorbitol Substances 0.000 claims 1
- 235000019157 thiamine Nutrition 0.000 claims 1
- 239000011721 thiamine Substances 0.000 claims 1
- KYMBYSLLVAOCFI-UHFFFAOYSA-N thiamine Chemical compound CC1=C(CCO)SCN1CC1=CN=C(C)N=C1N KYMBYSLLVAOCFI-UHFFFAOYSA-N 0.000 claims 1
- 229960003495 thiamine Drugs 0.000 claims 1
- 229940066528 trichloroacetate Drugs 0.000 claims 1
- YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 claims 1
- PLSARIKBYIPYPF-UHFFFAOYSA-H trimagnesium dicitrate Chemical compound [Mg+2].[Mg+2].[Mg+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O PLSARIKBYIPYPF-UHFFFAOYSA-H 0.000 claims 1
- 229940124549 vasodilator Drugs 0.000 claims 1
- 239000003071 vasodilator agent Substances 0.000 claims 1
- 235000019164 vitamin B2 Nutrition 0.000 claims 1
- 239000011716 vitamin B2 Substances 0.000 claims 1
- 235000019158 vitamin B6 Nutrition 0.000 claims 1
- 239000011726 vitamin B6 Substances 0.000 claims 1
- 229940011671 vitamin b6 Drugs 0.000 claims 1
- 150000003722 vitamin derivatives Chemical class 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITPCT/IT2005/000130 | 2005-03-10 | ||
| IT2005000130 | 2005-03-10 | ||
| PCT/EP2006/060162 WO2006094900A1 (en) | 2005-03-10 | 2006-02-22 | Carnitine-containing peritoneal dialysis solution having improved biocompatibility |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010146533A Division JP5366894B2 (ja) | 2005-03-10 | 2010-06-28 | 生体適合性が改善されたカルニチンを含有する腹膜透析液 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008532601A JP2008532601A (ja) | 2008-08-21 |
| JP2008532601A5 true JP2008532601A5 (enExample) | 2009-04-09 |
| JP4717110B2 JP4717110B2 (ja) | 2011-07-06 |
Family
ID=35159907
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008500161A Active JP4717110B2 (ja) | 2005-03-10 | 2006-02-22 | 生体適合性が改善されたカルニチンを含有する腹膜透析液 |
| JP2010146533A Active JP5366894B2 (ja) | 2005-03-10 | 2010-06-28 | 生体適合性が改善されたカルニチンを含有する腹膜透析液 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010146533A Active JP5366894B2 (ja) | 2005-03-10 | 2010-06-28 | 生体適合性が改善されたカルニチンを含有する腹膜透析液 |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US20080138443A1 (enExample) |
| EP (1) | EP1858504B1 (enExample) |
| JP (2) | JP4717110B2 (enExample) |
| KR (1) | KR101324920B1 (enExample) |
| AR (1) | AR054015A1 (enExample) |
| AT (1) | ATE539742T1 (enExample) |
| CA (1) | CA2599252C (enExample) |
| CY (1) | CY1112794T1 (enExample) |
| DK (1) | DK1858504T3 (enExample) |
| ES (1) | ES2380168T3 (enExample) |
| HR (1) | HRP20120177T1 (enExample) |
| ME (1) | ME02948B (enExample) |
| MX (1) | MX2007010814A (enExample) |
| PL (1) | PL1858504T3 (enExample) |
| PT (1) | PT1858504E (enExample) |
| RS (1) | RS52237B (enExample) |
| SI (1) | SI1858504T1 (enExample) |
| TW (1) | TWI388318B (enExample) |
| WO (1) | WO2006094900A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2365429B1 (es) * | 2010-03-05 | 2012-09-06 | Universidad De Castilla De La Mancha | Solucion para dialisis peritoneal |
| WO2018031922A1 (en) * | 2016-08-11 | 2018-02-15 | Sulfilatec, Inc. | Medical and nutritional compositions and methods of use |
| ES2750642A1 (es) * | 2018-09-26 | 2020-03-26 | Univ Vigo | Composición farmacéutica que comprende proteína amiloide P de suero para tratar la insuficiencia renal aguda o crónica |
| EP3912656A1 (en) * | 2020-05-19 | 2021-11-24 | CoreQuest Sagl | Peritoneal dialysis solution |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5126373A (en) | 1987-11-19 | 1992-06-30 | Henri Brunengraber | Composition for parenteral and oral nutrition |
| JPH08131542A (ja) * | 1994-11-11 | 1996-05-28 | Baxter Kk | 腹膜透析液調製用溶液セット |
| CA2155910C (en) | 1995-08-11 | 1999-12-14 | George Wu | Biocompatible aqueous solution for use in continuous ambulatory peritoneal dialysis |
| GB9714218D0 (en) * | 1997-07-04 | 1997-09-10 | Allied Therapeutics Ltd | Peritoneal dialysis fluid |
| US6537976B1 (en) | 1997-08-07 | 2003-03-25 | Ajay Gupta | Dialysis solutions containing water soluble vitamins and nutrients |
| DE19748290B8 (de) | 1997-10-31 | 2009-09-03 | Fresenius Medical Care Deutschland Gmbh | Lösung für die Peritonealdialyse |
| KR100642731B1 (ko) * | 1999-10-11 | 2006-11-03 | 시그마타우 인두스트리에 파르마슈티케 리우니테 에스.피.에이. | 의료용 용액에서 삼투제로서 ｌ-카르니틴 및 그의알카노일 유도체의 용도 |
| JP2002282354A (ja) | 2001-03-27 | 2002-10-02 | Jms Co Ltd | 腹膜透析液 |
| GB0108359D0 (en) * | 2001-04-03 | 2001-05-23 | Allied Therapeutics Ltd | Peritoneal dialysis fluid |
| ITRM20010337A1 (it) * | 2001-06-14 | 2002-12-16 | Sigma Tau Ind Farmaceuti | Soluzione per la conservazione e perfuzione di organi in attesa che vengano trapiantati. |
| FR2840612B1 (fr) * | 2002-06-06 | 2005-05-06 | Roquette Freres | Polymeres solubles de glucose hautement branches et leur procede d'obtention |
| JP2004016615A (ja) * | 2002-06-19 | 2004-01-22 | Fuso Pharmaceutical Industries Ltd | 晶質浸透圧剤及び膠質浸透圧剤を含有する腹膜透析液 |
| CA2508596A1 (en) | 2002-12-10 | 2004-06-24 | Gambro Lundia Ab | A method for preparing a medical solution for the manufacture of a medicament for peritoneal dialysis |
| JP2006075195A (ja) * | 2004-09-07 | 2006-03-23 | Jms Co Ltd | Ｌカルニチン含有腹膜透析液 |
-
2006
- 2006-02-20 TW TW095105650A patent/TWI388318B/zh active
- 2006-02-22 MX MX2007010814A patent/MX2007010814A/es active IP Right Grant
- 2006-02-22 AT AT06708437T patent/ATE539742T1/de active
- 2006-02-22 JP JP2008500161A patent/JP4717110B2/ja active Active
- 2006-02-22 ME MEP-2012-31A patent/ME02948B/me unknown
- 2006-02-22 DK DK06708437.6T patent/DK1858504T3/da active
- 2006-02-22 HR HR20120177T patent/HRP20120177T1/hr unknown
- 2006-02-22 ES ES06708437T patent/ES2380168T3/es active Active
- 2006-02-22 RS RS20120096A patent/RS52237B/sr unknown
- 2006-02-22 WO PCT/EP2006/060162 patent/WO2006094900A1/en not_active Ceased
- 2006-02-22 CA CA2599252A patent/CA2599252C/en active Active
- 2006-02-22 SI SI200631285T patent/SI1858504T1/sl unknown
- 2006-02-22 KR KR1020077023099A patent/KR101324920B1/ko not_active Expired - Fee Related
- 2006-02-22 EP EP06708437A patent/EP1858504B1/en active Active
- 2006-02-22 PL PL06708437T patent/PL1858504T3/pl unknown
- 2006-02-22 US US11/815,356 patent/US20080138443A1/en not_active Abandoned
- 2006-02-22 PT PT06708437T patent/PT1858504E/pt unknown
- 2006-03-09 AR ARP060100884A patent/AR054015A1/es unknown
-
2010
- 2010-06-28 JP JP2010146533A patent/JP5366894B2/ja active Active
-
2012
- 2012-03-30 CY CY20121100325T patent/CY1112794T1/el unknown
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