JP2005523269A5 - - Google Patents
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- Publication number
- JP2005523269A5 JP2005523269A5 JP2003565465A JP2003565465A JP2005523269A5 JP 2005523269 A5 JP2005523269 A5 JP 2005523269A5 JP 2003565465 A JP2003565465 A JP 2003565465A JP 2003565465 A JP2003565465 A JP 2003565465A JP 2005523269 A5 JP2005523269 A5 JP 2005523269A5
- Authority
- JP
- Japan
- Prior art keywords
- acid
- pharmaceutical composition
- pharmaceutically acceptable
- carnitine
- acetyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000002253 acid Substances 0.000 claims 9
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 5
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims 4
- RDHQFKQIGNGIED-MRVPVSSYSA-N O-acetyl-L-carnitine Chemical compound CC(=O)O[C@H](CC([O-])=O)C[N+](C)(C)C RDHQFKQIGNGIED-MRVPVSSYSA-N 0.000 claims 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims 2
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims 2
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims 2
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 2
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 claims 2
- 229910019142 PO4 Inorganic materials 0.000 claims 2
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims 2
- 229940009098 aspartate Drugs 0.000 claims 2
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 claims 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 2
- 239000010452 phosphate Substances 0.000 claims 2
- 229940095064 tartrate Drugs 0.000 claims 2
- NDVRKEKNSBMTAX-BTVCFUMJSA-N (2r,3s,4r,5r)-2,3,4,5,6-pentahydroxyhexanal;phosphoric acid Chemical compound OP(O)(O)=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O NDVRKEKNSBMTAX-BTVCFUMJSA-N 0.000 claims 1
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 claims 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims 1
- 208000020401 Depressive disease Diseases 0.000 claims 1
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 claims 1
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 claims 1
- DTQVDTLACAAQTR-UHFFFAOYSA-M Trifluoroacetate Chemical compound [O-]C(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-M 0.000 claims 1
- AWUCVROLDVIAJX-UHFFFAOYSA-N alpha-glycerophosphate Natural products OCC(O)COP(O)(O)=O AWUCVROLDVIAJX-UHFFFAOYSA-N 0.000 claims 1
- 235000015872 dietary supplement Nutrition 0.000 claims 1
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 claims 1
- PXQPEWDEAKTCGB-UHFFFAOYSA-N orotic acid Chemical compound OC(=O)C1=CC(=O)NC(=O)N1 PXQPEWDEAKTCGB-UHFFFAOYSA-N 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- AWUCVROLDVIAJX-GSVOUGTGSA-N sn-glycerol 3-phosphate Chemical compound OC[C@@H](O)COP(O)(O)=O AWUCVROLDVIAJX-GSVOUGTGSA-N 0.000 claims 1
- 239000012730 sustained-release form Substances 0.000 claims 1
- 229940066528 trichloroacetate Drugs 0.000 claims 1
- YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35432302P | 2002-02-07 | 2002-02-07 | |
| PCT/IT2003/000023 WO2003066041A1 (en) | 2002-02-07 | 2003-01-23 | Carnitine in the treatment of geriatric depression |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005523269A JP2005523269A (ja) | 2005-08-04 |
| JP2005523269A5 true JP2005523269A5 (enExample) | 2006-03-09 |
Family
ID=27734357
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003565465A Pending JP2005523269A (ja) | 2002-02-07 | 2003-01-23 | 老人性うつ病の治療におけるカルニチン |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20040009926A1 (enExample) |
| EP (1) | EP1471904A1 (enExample) |
| JP (1) | JP2005523269A (enExample) |
| KR (1) | KR20040083471A (enExample) |
| AR (1) | AR038350A1 (enExample) |
| AU (1) | AU2003219511A1 (enExample) |
| CA (1) | CA2469925A1 (enExample) |
| MX (1) | MXPA04007506A (enExample) |
| PL (1) | PL374082A1 (enExample) |
| WO (1) | WO2003066041A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050272812A1 (en) * | 2002-02-07 | 2005-12-08 | Pettegrew Jay W | Methor for use of acetyl-L-carnitine (ALCAR) for treatment of depressive disorders in humans |
| US7407778B2 (en) | 2002-02-07 | 2008-08-05 | Pettegrew Jay W | Compounds, compositions and methods for treating neuropsychiatric disorders |
| US7700074B2 (en) | 2002-02-07 | 2010-04-20 | Pettegrew Jay W | Method and system for diagnosis of neuropsychiatric disorders including chronic alcoholism |
| EP1641806B1 (en) | 2003-05-29 | 2009-07-29 | Jay W. Pettegrew | Glycerophosphocholine and its derivatives for medical imaging of neuropsychiatric disorders |
| PT2582368T (pt) | 2010-06-16 | 2018-06-04 | Alfasigma Spa | Acetil-carnitina, para utilização num método para o aumento da neurogénese em tecido neuronal |
| CA2964971C (en) | 2014-10-28 | 2023-04-11 | Medlab Ip Pty Ltd | Treatment for depression and depressive disorders |
| US11918336B2 (en) * | 2019-02-19 | 2024-03-05 | King Abdullah University Of Science And Technology | Reduced feature generation for signal classification based on position weight matrix |
| EP4149437A1 (en) | 2020-05-15 | 2023-03-22 | Alfasigma S.p.A. | Composition comprising methylfolate |
| CA3238205A1 (en) * | 2021-11-12 | 2023-05-19 | Rajaram Samant | A synergistic composition for activating intracellular secondary messenger(camp) pathway |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4346107A (en) * | 1979-02-12 | 1982-08-24 | Claudio Cavazza | Pharmaceutical composition comprising acyl-carnitine for the treatment of impaired cerebral metabolism |
| US5208037A (en) * | 1991-04-22 | 1993-05-04 | Alza Corporation | Dosage forms comprising polymers comprising different molecular weights |
| US5879884A (en) * | 1994-12-29 | 1999-03-09 | Peroutka; Stephen J. | Diagnosis of depression by linkage of a polymorphic marker to a segment of chromosome 19P13 bordered by D19S247 and D19S394 |
| JP3425276B2 (ja) * | 1995-08-11 | 2003-07-14 | 株式会社日立製作所 | 情報通知システム |
| JPH10143640A (ja) * | 1996-11-15 | 1998-05-29 | Nippon Lsi Card Kk | 携帯コンピュータ及びそれを用いた情報管理システム並びにそれを用いた立体地図の作成方法 |
| US5889055A (en) * | 1997-04-04 | 1999-03-30 | Howard; James R. | L-carnitine and acetyl-L-carnitine combined for prevention and treatment of syndromes related to diseases of energy metabolism |
-
2003
- 2003-01-23 JP JP2003565465A patent/JP2005523269A/ja active Pending
- 2003-01-23 WO PCT/IT2003/000023 patent/WO2003066041A1/en not_active Ceased
- 2003-01-23 AU AU2003219511A patent/AU2003219511A1/en not_active Abandoned
- 2003-01-23 MX MXPA04007506A patent/MXPA04007506A/es unknown
- 2003-01-23 PL PL03374082A patent/PL374082A1/xx unknown
- 2003-01-23 CA CA002469925A patent/CA2469925A1/en not_active Abandoned
- 2003-01-23 EP EP03715324A patent/EP1471904A1/en not_active Withdrawn
- 2003-01-23 KR KR10-2004-7009147A patent/KR20040083471A/ko not_active Ceased
- 2003-02-05 AR ARP030100356A patent/AR038350A1/es unknown
- 2003-02-07 US US10/359,560 patent/US20040009926A1/en not_active Abandoned
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