JP2004532866A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2004532866A5 JP2004532866A5 JP2002592920A JP2002592920A JP2004532866A5 JP 2004532866 A5 JP2004532866 A5 JP 2004532866A5 JP 2002592920 A JP2002592920 A JP 2002592920A JP 2002592920 A JP2002592920 A JP 2002592920A JP 2004532866 A5 JP2004532866 A5 JP 2004532866A5
- Authority
- JP
- Japan
- Prior art keywords
- acid
- per day
- therapeutic agent
- carnitine
- biotin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002253 acid Substances 0.000 claims 10
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims 8
- 239000003814 drug Substances 0.000 claims 5
- 229940124597 therapeutic agent Drugs 0.000 claims 5
- RDHQFKQIGNGIED-MRVPVSSYSA-N O-acetyl-L-carnitine Chemical compound CC(=O)O[C@H](CC([O-])=O)C[N+](C)(C)C RDHQFKQIGNGIED-MRVPVSSYSA-N 0.000 claims 4
- 229960002685 biotin Drugs 0.000 claims 4
- 235000020958 biotin Nutrition 0.000 claims 4
- 239000011616 biotin Substances 0.000 claims 4
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 3
- CNPURSDMOWDNOQ-UHFFFAOYSA-N 4-methoxy-7h-pyrrolo[2,3-d]pyrimidin-2-amine Chemical compound COC1=NC(N)=NC2=C1C=CN2 CNPURSDMOWDNOQ-UHFFFAOYSA-N 0.000 claims 2
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims 2
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims 2
- CCIVGXIOQKPBKL-UHFFFAOYSA-M ethanesulfonate Chemical compound CCS([O-])(=O)=O CCIVGXIOQKPBKL-UHFFFAOYSA-M 0.000 claims 2
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 claims 2
- -1 mucate Substances 0.000 claims 2
- 229940095064 tartrate Drugs 0.000 claims 2
- NDVRKEKNSBMTAX-BTVCFUMJSA-N (2r,3s,4r,5r)-2,3,4,5,6-pentahydroxyhexanal;phosphoric acid Chemical compound OP(O)(O)=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O NDVRKEKNSBMTAX-BTVCFUMJSA-N 0.000 claims 1
- QWJSAWXRUVVRLH-LREBCSMRSA-M 2-hydroxyethyl(trimethyl)azanium;(2r,3r)-2,3,4-trihydroxy-4-oxobutanoate Chemical compound C[N+](C)(C)CCO.OC(=O)[C@H](O)[C@@H](O)C([O-])=O QWJSAWXRUVVRLH-LREBCSMRSA-M 0.000 claims 1
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 claims 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims 1
- 206010022491 Insulin resistant diabetes Diseases 0.000 claims 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 1
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 claims 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims 1
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 claims 1
- 229910019142 PO4 Inorganic materials 0.000 claims 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims 1
- 229940009098 aspartate Drugs 0.000 claims 1
- 229910052749 magnesium Inorganic materials 0.000 claims 1
- 239000011777 magnesium Substances 0.000 claims 1
- 229960005336 magnesium citrate Drugs 0.000 claims 1
- 235000002538 magnesium citrate Nutrition 0.000 claims 1
- 239000004337 magnesium citrate Substances 0.000 claims 1
- 229940091250 magnesium supplement Drugs 0.000 claims 1
- 229940095060 magnesium tartrate Drugs 0.000 claims 1
- MUZDLCBWNVUYIR-ZVGUSBNCSA-L magnesium;(2r,3r)-2,3-dihydroxybutanedioate Chemical compound [Mg+2].[O-]C(=O)[C@H](O)[C@@H](O)C([O-])=O MUZDLCBWNVUYIR-ZVGUSBNCSA-L 0.000 claims 1
- QUIOHQITLKCGNW-TYYBGVCCSA-L magnesium;(e)-but-2-enedioate Chemical compound [Mg+2].[O-]C(=O)\C=C\C([O-])=O QUIOHQITLKCGNW-TYYBGVCCSA-L 0.000 claims 1
- PXQPEWDEAKTCGB-UHFFFAOYSA-N orotic acid Chemical compound OC(=O)C1=CC(=O)NC(=O)N1 PXQPEWDEAKTCGB-UHFFFAOYSA-N 0.000 claims 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 1
- 239000010452 phosphate Substances 0.000 claims 1
- 229940066528 trichloroacetate Drugs 0.000 claims 1
- YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 claims 1
- PLSARIKBYIPYPF-UHFFFAOYSA-H trimagnesium dicitrate Chemical compound [Mg+2].[Mg+2].[Mg+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O PLSARIKBYIPYPF-UHFFFAOYSA-H 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2001RM000294A ITRM20010294A1 (it) | 2001-05-29 | 2001-05-29 | Uso della acetil l-carnetina in associazione con la biotina per il trattamento di pazienti affetti da diabete mellito di tipo ii insulino re |
| PCT/IT2002/000338 WO2002096410A1 (en) | 2001-05-29 | 2002-05-24 | Use of the acetyl l-carnitine in association with the biotin for the treatment of patients with type 2 insulin-resistant diabetes mellitus |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004532866A JP2004532866A (ja) | 2004-10-28 |
| JP2004532866A5 true JP2004532866A5 (enExample) | 2006-01-05 |
| JP4381685B2 JP4381685B2 (ja) | 2009-12-09 |
Family
ID=11455558
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002592920A Expired - Fee Related JP4381685B2 (ja) | 2001-05-29 | 2002-05-24 | ２型インスリン抵抗性真性糖尿病患者の治療のためのビオチンと組合せてのアセチルｌ−カルニチンの使用 |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US20040142879A1 (enExample) |
| EP (1) | EP1399142B1 (enExample) |
| JP (1) | JP4381685B2 (enExample) |
| KR (1) | KR20040010666A (enExample) |
| AT (1) | ATE333274T1 (enExample) |
| CA (1) | CA2448244C (enExample) |
| CY (1) | CY1105403T1 (enExample) |
| CZ (1) | CZ297743B6 (enExample) |
| DE (1) | DE60213237T2 (enExample) |
| DK (1) | DK1399142T3 (enExample) |
| ES (1) | ES2268053T3 (enExample) |
| HU (1) | HUP0400060A2 (enExample) |
| IT (1) | ITRM20010294A1 (enExample) |
| MX (1) | MXPA03010921A (enExample) |
| PL (1) | PL207522B1 (enExample) |
| PT (1) | PT1399142E (enExample) |
| SK (1) | SK287832B6 (enExample) |
| WO (1) | WO2002096410A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU230002B1 (en) * | 2000-12-15 | 2015-04-28 | Sigma Tau Ind Farmaceuti | Use of l-carnitine for preparation of compositions for stabilizing the proteins |
| ITRM20040327A1 (it) * | 2004-07-01 | 2004-10-01 | Sigma Tau Ind Farmaceuti | Uso della acetil l-carnitina per la preparazione di un medicamento per il trattamento del dolore neuropatico in pazienti diabetici. |
| US8569366B2 (en) | 2005-04-26 | 2013-10-29 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Acetyl L-carnitine for prevention of painful peripheral neuropathy in patients with type 2 diabetes |
| EP1832295A1 (en) * | 2006-03-10 | 2007-09-12 | Tecnogen S.P.A. | Use of PTX3 for the treatment of viral diseases |
| ES2546619T3 (es) * | 2007-03-21 | 2015-09-25 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Composición útil para la prevención de la diabetes tipo 2 y sus complicaciones en pacientes pre-diabéticos con resistencia a la insulina |
| GB201304112D0 (en) * | 2013-03-07 | 2013-04-24 | Univ Nottingham | Modulation of energy expenditure |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1196564B (it) * | 1986-08-04 | 1988-11-16 | Sigma Tau Ind Farmaceuti | Impiego di acetil l-carnitina nel trattamento terapeutico delle neuropatie periferiche |
| IT1263004B (it) * | 1992-10-08 | 1996-07-23 | Sigma Tau Ind Farmaceuti | Impiego della l-carnitina e acil l-carnitine nel trattamento a lungo termine di pazienti diabetici non insulino-dipendenti. |
| US6020139A (en) * | 1995-04-25 | 2000-02-01 | Oridigm Corporation | S-adenosyl methionine regulation of metabolic pathways and its use in diagnosis and therapy |
| US5789401A (en) * | 1997-08-08 | 1998-08-04 | Nutrition 21 | High-dose chromium/biotin treatment of type II diabetes |
-
2001
- 2001-05-29 IT IT2001RM000294A patent/ITRM20010294A1/it unknown
-
2002
- 2002-05-24 PL PL367630A patent/PL207522B1/pl not_active IP Right Cessation
- 2002-05-24 HU HU0400060A patent/HUP0400060A2/hu unknown
- 2002-05-24 WO PCT/IT2002/000338 patent/WO2002096410A1/en not_active Ceased
- 2002-05-24 ES ES02741155T patent/ES2268053T3/es not_active Expired - Lifetime
- 2002-05-24 MX MXPA03010921A patent/MXPA03010921A/es active IP Right Grant
- 2002-05-24 CA CA2448244A patent/CA2448244C/en not_active Expired - Fee Related
- 2002-05-24 CZ CZ20033221A patent/CZ297743B6/cs not_active IP Right Cessation
- 2002-05-24 US US10/478,372 patent/US20040142879A1/en not_active Abandoned
- 2002-05-24 SK SK1585-2003A patent/SK287832B6/sk not_active IP Right Cessation
- 2002-05-24 EP EP02741155A patent/EP1399142B1/en not_active Expired - Lifetime
- 2002-05-24 JP JP2002592920A patent/JP4381685B2/ja not_active Expired - Fee Related
- 2002-05-24 PT PT02741155T patent/PT1399142E/pt unknown
- 2002-05-24 DK DK02741155T patent/DK1399142T3/da active
- 2002-05-24 KR KR10-2003-7015575A patent/KR20040010666A/ko not_active Ceased
- 2002-05-24 AT AT02741155T patent/ATE333274T1/de active
- 2002-05-24 DE DE60213237T patent/DE60213237T2/de not_active Expired - Lifetime
-
2006
- 2006-09-25 CY CY20061101375T patent/CY1105403T1/el unknown
-
2008
- 2008-07-02 US US12/216,279 patent/US8053472B2/en not_active Expired - Fee Related
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| FI3164125T3 (fi) | Menetelmiä ja koostumuksia liikalihavuuden hoitamiseksi, painonnousun ehkäisemiseksi, painonpudotuksen edistämiseksi, laihtumisen edistämiseksi tai diabeteksen hoitamiseksi tai sen kehittymisen ehkäisemiseksi | |
| JP2006506361A5 (enExample) | ||
| JP2001526234A5 (enExample) | ||
| JP2004532866A5 (enExample) | ||
| US8053472B2 (en) | Use of the acetyl L-carnitine in association with the biotin for the treatment of patients with type 2 insulin-resistant diabetes mellitus | |
| JP2005511655A5 (enExample) | ||
| JPH0616570A (ja) | 心臓血管障害の処置のためのａｃｅ阻害剤を配合するｌ−カルニチンまたはアシル−ｌ−カルニチンを含む医薬組成物 | |
| CN1299283A (zh) | 包含l－肉毒碱或烷酰基l－肉毒碱和nadh和/或nadph的组合物 | |
| CA2465471A1 (en) | Use of alkanoyl l-carnitine for the treatment of erectile dysfunction | |
| KR970073581A (ko) | 초로기성 알쯔하이머 질환 치료용 카르니틴 유도체 함유 의약품 | |
| CA2507429A1 (en) | Use of carnitines for the prevention and/or treatment of disorders caused by the andropause | |
| JP2008505134A5 (enExample) | ||
| JP2006511531A5 (enExample) | ||
| JP2004532865A5 (enExample) | ||
| CA2448242A1 (en) | Use of acetyl l-carnitine for the preparation of a medication for the preventive therapy for pain | |
| CN1717232A (zh) | L－肉碱用于治疗心血管疾病的用途 | |
| JP2008539191A5 (enExample) | ||
| KR100725263B1 (ko) | ＨＭＧ-ＣｏＡ 리덕타제 억제제 및 카르니틴을 포함하는 항지질혈성 복합제 | |
| JP2004532867A5 (enExample) | ||
| CN101087602B (zh) | L-肉碱和葡萄糖治疗心血管疾病的应用 | |
| JP2008517872A5 (enExample) | ||
| JPH05194207A (ja) | 特発性精子過少症の処置のためのｌ−カルニチンおよびアシル−ｌ−カルニチンの使用 | |
| JP2003512426A5 (enExample) | ||
| JP2002529408A5 (enExample) | ||
| CA2434962A1 (en) | Use of isovaleryl l-carnitine for the treatment of fractures |