JP2001526234A5 - - Google Patents
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- Publication number
- JP2001526234A5 JP2001526234A5 JP2000525119A JP2000525119A JP2001526234A5 JP 2001526234 A5 JP2001526234 A5 JP 2001526234A5 JP 2000525119 A JP2000525119 A JP 2000525119A JP 2000525119 A JP2000525119 A JP 2000525119A JP 2001526234 A5 JP2001526234 A5 JP 2001526234A5
- Authority
- JP
- Japan
- Prior art keywords
- dosage form
- ribavirin
- solid dosage
- composition
- orally administrable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- IWUCXVSUMQZMFG-AFCXAGJDSA-N Ribavirin Chemical compound N1=C(C(=O)N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 IWUCXVSUMQZMFG-AFCXAGJDSA-N 0.000 description 25
- 229960000329 ribavirin Drugs 0.000 description 25
- HZCAHMRRMINHDJ-DBRKOABJSA-N ribavirin Natural products O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1N=CN=C1 HZCAHMRRMINHDJ-DBRKOABJSA-N 0.000 description 25
- 239000007909 solid dosage form Substances 0.000 description 23
- 239000000203 mixture Substances 0.000 description 16
- 239000002552 dosage form Substances 0.000 description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 6
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 5
- 239000007884 disintegrant Substances 0.000 description 5
- 229920002785 Croscarmellose sodium Polymers 0.000 description 4
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 4
- 239000002775 capsule Substances 0.000 description 4
- 229960001681 croscarmellose sodium Drugs 0.000 description 4
- 235000010947 crosslinked sodium carboxy methyl cellulose Nutrition 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 239000008108 microcrystalline cellulose Substances 0.000 description 4
- 229940016286 microcrystalline cellulose Drugs 0.000 description 4
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 4
- WSVLPVUVIUVCRA-KPKNDVKVSA-N Alpha-lactose monohydrate Chemical compound O.O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O WSVLPVUVIUVCRA-KPKNDVKVSA-N 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 229960001021 lactose monohydrate Drugs 0.000 description 3
- 235000019359 magnesium stearate Nutrition 0.000 description 3
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 3
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 3
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 3
- 208000006154 Chronic hepatitis C Diseases 0.000 description 2
- 208000005176 Hepatitis C Diseases 0.000 description 2
- 102100040018 Interferon alpha-2 Human genes 0.000 description 2
- 108010079944 Interferon-alpha2b Proteins 0.000 description 2
- 229920000881 Modified starch Polymers 0.000 description 2
- 235000010443 alginic acid Nutrition 0.000 description 2
- 229920000615 alginic acid Polymers 0.000 description 2
- 239000000945 filler Substances 0.000 description 2
- 208000010710 hepatitis C virus infection Diseases 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 239000000314 lubricant Substances 0.000 description 2
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 description 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- 229920002261 Corn starch Polymers 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- 239000008118 PEG 6000 Substances 0.000 description 1
- 229920001030 Polyethylene Glycol 4000 Polymers 0.000 description 1
- 229920002584 Polyethylene Glycol 6000 Polymers 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- 229940072056 alginate Drugs 0.000 description 1
- 239000000783 alginic acid Substances 0.000 description 1
- 229960001126 alginic acid Drugs 0.000 description 1
- 150000004781 alginic acids Chemical class 0.000 description 1
- 229940009868 aluminum magnesium silicate Drugs 0.000 description 1
- WMGSQTMJHBYJMQ-UHFFFAOYSA-N aluminum;magnesium;silicate Chemical compound [Mg+2].[Al+3].[O-][Si]([O-])([O-])[O-] WMGSQTMJHBYJMQ-UHFFFAOYSA-N 0.000 description 1
- 235000012216 bentonite Nutrition 0.000 description 1
- 239000000440 bentonite Substances 0.000 description 1
- 229940092782 bentonite Drugs 0.000 description 1
- 229910000278 bentonite Inorganic materials 0.000 description 1
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 1
- XAAHAAMILDNBPS-UHFFFAOYSA-L calcium hydrogenphosphate dihydrate Chemical compound O.O.[Ca+2].OP([O-])([O-])=O XAAHAAMILDNBPS-UHFFFAOYSA-L 0.000 description 1
- CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical compound [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 description 1
- 239000008116 calcium stearate Substances 0.000 description 1
- 235000013539 calcium stearate Nutrition 0.000 description 1
- PASHVRUKOFIRIK-UHFFFAOYSA-L calcium sulfate dihydrate Chemical compound O.O.[Ca+2].[O-]S([O-])(=O)=O PASHVRUKOFIRIK-UHFFFAOYSA-L 0.000 description 1
- ILWNTWRKKKGJCG-UHFFFAOYSA-L calcium;sulfate;trihydrate Chemical compound O.O.O.[Ca+2].[O-]S([O-])(=O)=O ILWNTWRKKKGJCG-UHFFFAOYSA-L 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 239000008120 corn starch Substances 0.000 description 1
- 229940099112 cornstarch Drugs 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 229960001855 mannitol Drugs 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 239000008184 oral solid dosage form Substances 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920001592 potato starch Polymers 0.000 description 1
- HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 229920003109 sodium starch glycolate Polymers 0.000 description 1
- 239000008109 sodium starch glycolate Substances 0.000 description 1
- 229940079832 sodium starch glycolate Drugs 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 229960004793 sucrose Drugs 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- XOOUIPVCVHRTMJ-UHFFFAOYSA-L zinc stearate Chemical compound [Zn+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O XOOUIPVCVHRTMJ-UHFFFAOYSA-L 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/997,172 | 1997-12-22 | ||
| US08/997,169 US5916594A (en) | 1997-12-22 | 1997-12-22 | Process of making solid ribavirin dosage forms |
| US08/997,169 | 1997-12-22 | ||
| US08/997,172 US5914128A (en) | 1997-12-22 | 1997-12-22 | Orally administrable solid dosage form |
| PCT/US1998/026222 WO1999032128A1 (en) | 1997-12-22 | 1998-12-21 | Orally administrable solid ribavirin dosage forms and process for making them |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005358349A Division JP2006083189A (ja) | 1997-12-22 | 2005-12-12 | 経口投与が可能な固形リバビリン投薬の形態およびそれらの製造プロセス |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2001526234A JP2001526234A (ja) | 2001-12-18 |
| JP2001526234A5 true JP2001526234A5 (enExample) | 2006-02-16 |
Family
ID=27130673
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000525119A Pending JP2001526234A (ja) | 1997-12-22 | 1998-12-21 | 経口投与が可能な固形リバビリン投薬の形態およびそれらの製造プロセス |
| JP2005358349A Pending JP2006083189A (ja) | 1997-12-22 | 2005-12-12 | 経口投与が可能な固形リバビリン投薬の形態およびそれらの製造プロセス |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005358349A Pending JP2006083189A (ja) | 1997-12-22 | 2005-12-12 | 経口投与が可能な固形リバビリン投薬の形態およびそれらの製造プロセス |
Country Status (26)
| Country | Link |
|---|---|
| US (3) | US6337090B1 (enExample) |
| EP (2) | EP1321147A1 (enExample) |
| JP (2) | JP2001526234A (enExample) |
| KR (1) | KR100575389B1 (enExample) |
| CN (1) | CN1155388C (enExample) |
| AR (1) | AR008977A1 (enExample) |
| AT (1) | ATE234103T1 (enExample) |
| AU (1) | AU762826B2 (enExample) |
| BR (1) | BR9814367A (enExample) |
| CA (4) | CA2300452C (enExample) |
| CO (1) | CO4970774A1 (enExample) |
| DE (1) | DE69812094T2 (enExample) |
| DK (1) | DK0991415T3 (enExample) |
| ES (1) | ES2191987T3 (enExample) |
| HU (1) | HUP0100433A3 (enExample) |
| IL (1) | IL136549A (enExample) |
| MY (1) | MY119656A (enExample) |
| NO (1) | NO20003234L (enExample) |
| NZ (1) | NZ504994A (enExample) |
| PE (1) | PE20000066A1 (enExample) |
| PL (1) | PL190267B1 (enExample) |
| PT (1) | PT991415E (enExample) |
| SK (1) | SK284520B6 (enExample) |
| TW (1) | TW575436B (enExample) |
| WO (1) | WO1999032128A1 (enExample) |
| ZA (1) | ZA9811726B (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK0991415T3 (da) * | 1997-12-22 | 2003-06-16 | Schering Corp | Faste, oralt indgivelige dosisformer for ribavirin og fremgangsmåde til fremstilling af disse |
| US6793934B1 (en) * | 1999-12-08 | 2004-09-21 | Shire Laboratories, Inc. | Solid oral dosage form |
| US6702810B2 (en) * | 2000-03-06 | 2004-03-09 | Tissuelink Medical Inc. | Fluid delivery system and controller for electrosurgical devices |
| US6720000B2 (en) * | 2001-03-19 | 2004-04-13 | Three Rivers Pharmaceutical, Llc | Process for producing wet ribavirin pellets |
| KR20030020137A (ko) * | 2001-09-03 | 2003-03-08 | 진양제약주식회사 | 리바비린 건조시럽제 |
| AU2002350082B9 (en) * | 2001-11-02 | 2006-08-31 | Sandoz Inc. | Process for preparing quick dissolving, high loading ribavirin compositions |
| DE10227148A1 (de) * | 2002-06-18 | 2004-01-08 | Biopartners Gmbh | Verwendung von Ribavirin zur Herstellung einer pharmazeutischen Zusammensetzung gegen Bunyaviridae |
| US7538094B2 (en) * | 2002-09-19 | 2009-05-26 | Three Rivers Pharmacueticals, Llc | Composition containing ribavirin and use thereof |
| US20040142903A1 (en) * | 2003-01-16 | 2004-07-22 | Par Pharmaceutical Inc. | Bioavailable fenofibrate compositions, methods for treating hyperlipidemia and hypercholesterolemia and processes for the preparation of such compositions |
| CA2529311A1 (en) * | 2003-03-28 | 2004-10-07 | Pharmasset, Inc. | Compounds for the treatment of flaviviridae infections |
| WO2006027125A1 (en) * | 2004-09-09 | 2006-03-16 | Bayer Healthcare Ag | Pharmaceutical composition in the form of a water soluble solid dosage form |
| US7723310B2 (en) * | 2004-10-18 | 2010-05-25 | Three Rivers Pharmaceuticals, Llc | Large dose ribavirin formulations |
| EP1917301B1 (en) * | 2005-08-05 | 2014-04-23 | 3M Innovative Properties Company | Compositions exhibiting improved flowability |
| EP2054076A2 (en) * | 2006-08-21 | 2009-05-06 | United Therapeutics Corporation | Combination therapy for treatment of viral infections |
| EP2296628B1 (en) * | 2008-05-22 | 2014-05-14 | 3M Innovative Properties Company | Process for manufacturing flowable powder drug compositions |
| WO2009158300A1 (en) * | 2008-06-26 | 2009-12-30 | 3M Innovative Properties Company | Dry powder pharmaceutical compositions for pulmonary administration, and methods of manufacturing thereof |
| US9861580B2 (en) * | 2008-07-02 | 2018-01-09 | 3M Innovative Properties Company | Method of making a dry powder pharmaceutical composition |
| EP2295037A1 (en) | 2009-09-11 | 2011-03-16 | Ratiopharm GmbH | Pharmaceutical formulation containing Ribavirin |
| US10363453B2 (en) | 2011-02-07 | 2019-07-30 | New Balance Athletics, Inc. | Systems and methods for monitoring athletic and physiological performance |
| CA2752008A1 (en) | 2011-09-13 | 2013-03-13 | Universite De Montreal | Combination therapy using ribavirin as elf4e inhibitor |
| CN106389363A (zh) * | 2016-10-18 | 2017-02-15 | 广东肇庆星湖生物科技股份有限公司 | 一种利巴韦林口服固体制剂及其制备方法 |
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| DE1228029C2 (de) * | 1964-05-09 | 1973-05-17 | Merck Ag E | Verfahren zur Herstellung von Tabletten durch Pressen von Pulvergemischen ohne vorhergehende Granulation |
| US3490742A (en) * | 1966-01-14 | 1970-01-20 | Staley Mfg Co A E | Compressed tablets |
| US3622677A (en) * | 1969-07-07 | 1971-11-23 | Staley Mfg Co A E | Compressed tablets containing compacted starch as binder-disintegrant ingredient |
| US4211771A (en) * | 1971-06-01 | 1980-07-08 | Robins Ronald K | Treatment of human viral diseases with 1-B-D-ribofuranosyl-1,2,4-triazole-3-carboxamide |
| DE2735600A1 (de) * | 1977-08-06 | 1979-02-15 | Dynamit Nobel Ag | Verfahren zur herstellung von phthalid |
| JPS57146593A (en) * | 1981-03-09 | 1982-09-10 | Ajinomoto Co Inc | Preparation of ribofuranosyltriazole derivative |
| US4609675A (en) * | 1984-08-17 | 1986-09-02 | The Upjohn Company | Stable, high dose, high bulk density ibuprofen granulations for tablet and capsule manufacturing |
| US4681765A (en) * | 1984-09-13 | 1987-07-21 | American Home Products Corporation | Rapid releasing triamterene containing gelatin capsule dosage forms for once daily antihypertensive use |
| US5084445A (en) * | 1986-05-01 | 1992-01-28 | University Of Georgia Research Foundation, Inc. | 3'-azido-2',3'-dideoxy-5-methylcytidine |
| US5077279A (en) * | 1986-05-01 | 1991-12-31 | University Of Georgia Research Foundation, Inc. | 3'-azido-2',3'-dideoxy-5-methylcytidine anti-viral composition |
| GB8628359D0 (en) * | 1986-11-27 | 1986-12-31 | Zyma Sa | Galenical formulation |
| JPS63216820A (ja) * | 1987-03-05 | 1988-09-09 | Chugai Pharmaceut Co Ltd | 抗ウイルス剤 |
| GB8800276D0 (en) * | 1988-01-07 | 1988-02-10 | Univ Liverpool | Medical treatment |
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| US5109016A (en) * | 1988-05-23 | 1992-04-28 | Georgia State University Foundation, Inc. | Method for inhibiting infection or replication of human immunodeficiency virus with porphyrin and phthalocyanine antiviral compositions |
| US5192788A (en) * | 1988-05-23 | 1993-03-09 | Georgia State University Foundation, Inc. | Porphyrin antiviral compositions |
| US5122517A (en) * | 1988-06-10 | 1992-06-16 | Regents Of The University Of Minnesota | Antiviral combination comprising nucleoside analogs |
| NZ229453A (en) * | 1988-06-10 | 1991-08-27 | Univ Minnesota & Southern Rese | A pharmaceutical composition containing purine derivatives with nucleosides such as azt, as antiviral agents |
| JP2908844B2 (ja) * | 1990-06-29 | 1999-06-21 | ヤマサ醤油株式会社 | 抗ウイルス剤 |
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| US5869097A (en) * | 1992-11-02 | 1999-02-09 | Alza Corporation | Method of therapy comprising an osmotic caplet |
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| JPH06298665A (ja) * | 1993-04-14 | 1994-10-25 | Toray Ind Inc | 抗ウイルス剤 |
| US5506248A (en) * | 1993-08-02 | 1996-04-09 | Bristol-Myers Squibb Company | Pharmaceutical compositions having good dissolution properties |
| US5492692A (en) * | 1993-08-17 | 1996-02-20 | University Of Kentucky Research Foundation | Coated products with potent anti-HIV and antimicrobial properties |
| US5370878A (en) * | 1993-09-30 | 1994-12-06 | Hallmark Pharmaceuticals, Inc. | Method for preparing a direct compression granulated acetaminophen composition |
| US5605889A (en) * | 1994-04-29 | 1997-02-25 | Pfizer Inc. | Method of administering azithromycin |
| CA2135669A1 (en) | 1994-11-10 | 1996-05-11 | Nils O. Johannesson | Ribavirin as hepato (liver) protecting agent |
| US5948438A (en) * | 1995-01-09 | 1999-09-07 | Edward Mendell Co., Inc. | Pharmaceutical formulations having improved disintegration and/or absorptivity |
| US5585115A (en) * | 1995-01-09 | 1996-12-17 | Edward H. Mendell Co., Inc. | Pharmaceutical excipient having improved compressability |
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| IL139728A (en) * | 1995-01-09 | 2003-06-24 | Penwest Pharmaceuticals Compan | Aqueous slurry composition containing microcrystalline cellulose for preparing a pharmaceutical excipient |
| AU701042B2 (en) * | 1995-02-28 | 1999-01-21 | Aventisub Llc | Pharmaceutical composition for piperidinoalkanol compounds |
| US6387365B1 (en) * | 1995-05-19 | 2002-05-14 | Schering Corporation | Combination therapy for chronic hepatitis C infection |
| US5733578A (en) * | 1995-11-15 | 1998-03-31 | Edward Mendell Co., Inc. | Directly compressible high load acetaminophen formulations |
| US5723589A (en) * | 1995-12-21 | 1998-03-03 | Icn Pharmaceuticals | Carbohydrate conjugated bio-active compounds |
| IT1282650B1 (it) * | 1996-02-19 | 1998-03-31 | Jagotec Ag | Compressa farmaceutica,caratterizzata da elevato aumento di volume a contatto con liquidi biologici |
| US6172046B1 (en) * | 1997-09-21 | 2001-01-09 | Schering Corporation | Combination therapy for eradicating detectable HCV-RNA in patients having chronic Hepatitis C infection |
| DK0991415T3 (da) * | 1997-12-22 | 2003-06-16 | Schering Corp | Faste, oralt indgivelige dosisformer for ribavirin og fremgangsmåde til fremstilling af disse |
| US5916594A (en) * | 1997-12-22 | 1999-06-29 | Schering Corporation | Process of making solid ribavirin dosage forms |
| US5914128A (en) * | 1997-12-22 | 1999-06-22 | Schering Corporation | Orally administrable solid dosage form |
-
1998
- 1998-12-21 DK DK98965983T patent/DK0991415T3/da active
- 1998-12-21 MY MYPI98005792A patent/MY119656A/en unknown
- 1998-12-21 EP EP02023032A patent/EP1321147A1/en not_active Withdrawn
- 1998-12-21 ZA ZA9811726A patent/ZA9811726B/xx unknown
- 1998-12-21 PE PE1998001256A patent/PE20000066A1/es not_active Application Discontinuation
- 1998-12-21 ES ES98965983T patent/ES2191987T3/es not_active Expired - Lifetime
- 1998-12-21 BR BR9814367-0A patent/BR9814367A/pt not_active Application Discontinuation
- 1998-12-21 CA CA002300452A patent/CA2300452C/en not_active Expired - Fee Related
- 1998-12-21 HU HU0100433A patent/HUP0100433A3/hu unknown
- 1998-12-21 CN CNB988124858A patent/CN1155388C/zh not_active Expired - Fee Related
- 1998-12-21 PL PL98341230A patent/PL190267B1/pl not_active IP Right Cessation
- 1998-12-21 US US09/582,060 patent/US6337090B1/en not_active Expired - Fee Related
- 1998-12-21 KR KR1020007006927A patent/KR100575389B1/ko not_active Expired - Fee Related
- 1998-12-21 JP JP2000525119A patent/JP2001526234A/ja active Pending
- 1998-12-21 PT PT98965983T patent/PT991415E/pt unknown
- 1998-12-21 EP EP98965983A patent/EP0991415B1/en not_active Expired - Lifetime
- 1998-12-21 DE DE69812094T patent/DE69812094T2/de not_active Expired - Lifetime
- 1998-12-21 WO PCT/US1998/026222 patent/WO1999032128A1/en not_active Ceased
- 1998-12-21 NZ NZ504994A patent/NZ504994A/xx unknown
- 1998-12-21 AU AU21991/99A patent/AU762826B2/en not_active Ceased
- 1998-12-21 SK SK894-2000A patent/SK284520B6/sk not_active IP Right Cessation
- 1998-12-21 IL IL13654998A patent/IL136549A/xx not_active IP Right Cessation
- 1998-12-21 CA CA002365412A patent/CA2365412C/en not_active Expired - Fee Related
- 1998-12-21 AT AT98965983T patent/ATE234103T1/de active
- 1998-12-21 AR ARP980106567A patent/AR008977A1/es unknown
- 1998-12-21 CA CA002287056A patent/CA2287056C/en not_active Expired - Fee Related
- 1998-12-21 CA CA002323849A patent/CA2323849C/en not_active Expired - Fee Related
- 1998-12-22 CO CO98075938A patent/CO4970774A1/es unknown
- 1998-12-24 TW TW87121436A patent/TW575436B/zh not_active IP Right Cessation
-
1999
- 1999-05-07 US US09/307,008 patent/US6051252A/en not_active Expired - Fee Related
-
2000
- 2000-03-06 US US09/518,871 patent/US6335032B1/en not_active Expired - Fee Related
- 2000-06-21 NO NO20003234A patent/NO20003234L/no not_active Application Discontinuation
-
2005
- 2005-12-12 JP JP2005358349A patent/JP2006083189A/ja active Pending
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