RU2003135201A - Применение антагониста опиоидов налтрексона для предупреждения и контроля побочных воздействий, вызванных опиоидами - Google Patents
Применение антагониста опиоидов налтрексона для предупреждения и контроля побочных воздействий, вызванных опиоидами Download PDFInfo
- Publication number
- RU2003135201A RU2003135201A RU2003135201/15A RU2003135201A RU2003135201A RU 2003135201 A RU2003135201 A RU 2003135201A RU 2003135201/15 A RU2003135201/15 A RU 2003135201/15A RU 2003135201 A RU2003135201 A RU 2003135201A RU 2003135201 A RU2003135201 A RU 2003135201A
- Authority
- RU
- Russia
- Prior art keywords
- naltrexone
- morphine
- prevention
- control
- per
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
- A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Electrotherapy Devices (AREA)
- Compositions Of Oxide Ceramics (AREA)
- Medicinal Preparation (AREA)
Claims (6)
1. Применение налтрексона для приготовления фармацевтических композиций, пригодных для предупреждения и контроля побочных воздействий, которые связаны с лечением морфином, предназначенных для перорального введения в дозе от 0,01 до 0,9 мг на мг вводимого морфина.
2. Фармацевтические композиции в состоящей из нескольких ингредиентов форме, пригодные для контроля побочных воздействий, которые связаны с лечением морфином, отличающиеся тем, что они представляют собой сахарозные и крахмальные гранулы, на которые нанесено покрытие из поливинилпирролидона и слой налтрексона.
3. Композиция по п.2, в которой содержание налтрексона составляет 0,005-0,1 мг на 1 мг композиции.
4. Композиция по п.2, приготовленная в виде твердых желатиновых капсул, в которых содержание налтрексона составляет 0,25-0,9 мг на стандартную дозу композиции.
5. Терапевтический способ для контроля побочных воздействий, которые связаны с лечением морфином, предусматривающий пероральное введение композиции по п.2, из расчета от 0,01 до 0,9 мг налтрексона на 1 мг морфина.
6. Способ по п.5, где введение налтрексона осуществляют за 0,5 ч до введения морфина.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI2001A000907 | 2001-05-02 | ||
IT2001MI000907A ITMI20010907A1 (it) | 2001-05-02 | 2001-05-02 | Impiego di antagonisti oppioidi per la prevenzione ed il controllo degli effetti collaterali prodotti dagli oppioidi |
Publications (1)
Publication Number | Publication Date |
---|---|
RU2003135201A true RU2003135201A (ru) | 2005-03-27 |
Family
ID=11447580
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU2003135201/15A RU2003135201A (ru) | 2001-05-02 | 2002-05-02 | Применение антагониста опиоидов налтрексона для предупреждения и контроля побочных воздействий, вызванных опиоидами |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1395260A1 (ru) |
IT (1) | ITMI20010907A1 (ru) |
RU (1) | RU2003135201A (ru) |
WO (1) | WO2002087582A1 (ru) |
ZA (1) | ZA200309333B (ru) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MY135852A (en) * | 2003-04-21 | 2008-07-31 | Euro Celtique Sa | Pharmaceutical products |
US20060063792A1 (en) * | 2004-09-17 | 2006-03-23 | Adolor Corporation | Substituted morphinans and methods of their use |
US9056054B2 (en) | 2009-06-25 | 2015-06-16 | Elite Laboratories, Inc. | Abuse resistant oral dosage forms |
US20140179727A1 (en) | 2012-12-14 | 2014-06-26 | Trevi Therapeutics, Inc. | Methods for treating pruritus |
US8637538B1 (en) | 2012-12-14 | 2014-01-28 | Trevi Therapeutics, Inc. | Methods for treatment of pruritis |
US8987289B2 (en) | 2012-12-14 | 2015-03-24 | Trevi Therapeutics, Inc. | Methods for treating pruritus |
US20200022974A1 (en) | 2018-07-23 | 2020-01-23 | Trevi Therapeutics, Inc. | Treatment of chronic cough, breathlessness and dyspnea |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6096756A (en) * | 1992-09-21 | 2000-08-01 | Albert Einstein College Of Medicine Of Yeshiva University | Method of simultaneously enhancing analgesic potency and attenuating dependence liability caused by morphine and other bimodally-acting opioid agonists |
US5512578A (en) * | 1992-09-21 | 1996-04-30 | Albert Einstein College Of Medicine Of Yeshiva University, A Division Of Yeshiva University | Method of simultaneously enhancing analgesic potency and attenuating dependence liability caused by exogenous and endogenous opiod agonists |
US20010006967A1 (en) * | 1992-09-21 | 2001-07-05 | Stanley M. Crain | Method of simultaneously enhancing analgesic potency and attenuating adverse side effects caused by tramadol and other bimodally-acting opioid agonists |
US5580876A (en) * | 1992-09-21 | 1996-12-03 | Albert Einstein College Of Medicine Of Yeshiva University, A Division Of Yeshiva University | Method of simultaneously enhancing analgesic potency and attenuating dependence liability caused by morphine and other bimodally-acting opioid agonists |
ATE323491T1 (de) * | 1997-12-22 | 2006-05-15 | Euro Celtique Sa | Peroral zu verabreichende arzneiform enthaltend eine kombination von einem opioid agonisten und naltrexon |
US6525062B2 (en) * | 2000-06-09 | 2003-02-25 | The Regents Of The University Of California | Method of treating pain using nalbuphine and opioid antagonists |
-
2001
- 2001-05-02 IT IT2001MI000907A patent/ITMI20010907A1/it unknown
-
2002
- 2002-05-02 RU RU2003135201/15A patent/RU2003135201A/ru not_active Application Discontinuation
- 2002-05-02 WO PCT/IB2002/001473 patent/WO2002087582A1/en not_active Application Discontinuation
- 2002-05-02 EP EP02726358A patent/EP1395260A1/en not_active Withdrawn
-
2003
- 2003-12-01 ZA ZA200309333A patent/ZA200309333B/en unknown
Also Published As
Publication number | Publication date |
---|---|
ITMI20010907A0 (it) | 2001-05-02 |
ZA200309333B (en) | 2004-02-17 |
WO2002087582A1 (en) | 2002-11-07 |
ITMI20010907A1 (it) | 2002-11-02 |
EP1395260A1 (en) | 2004-03-10 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
KR100417490B1 (ko) | 오피오이드 제형의 남용을 방지하는 방법 | |
RU2004106619A (ru) | Композиции опиоидного агониста, содержащие высвобождаемый и изолированный антагонист | |
JP2004515455A (ja) | オピオイドアンタゴニスト組成物および投薬形態 | |
US20170333422A1 (en) | Morphinan Derivatives for the Treatment of Drug Overdose | |
US20030191147A1 (en) | Opioid antagonist compositions and dosage forms | |
JP2000508341A (ja) | 片頭痛の治療法及び薬効の強化組成物 | |
US20100093712A1 (en) | Two-component pharmaceutical composition for the treatment of pain | |
JP2005515966A5 (ru) | ||
JP2003534378A (ja) | フェンタニル型構造のオピオイドおよびケタミンを含有する有効成分の組合せ | |
CA2661759A1 (en) | Buprenophine-wafer for drug substitution therapy | |
WO2011008298A2 (en) | Novel axomadol dosage forms | |
RU2003116058A (ru) | Композиции гидрокодона с контролируемым высвобождением | |
JP2005512995A5 (ru) | ||
JP2005511647A (ja) | 経口用および口内用の成型粉薬錠剤を伴う圧縮環状錠剤 | |
IL149496A (en) | Pharmaceutical compositions and their use in the treatment of the gastrointestinal tract | |
CA2709905A1 (en) | Abuse-resistant oxycodone composition | |
TW200836738A (en) | Improvements in or relating to medicinal compositions | |
CN1747725A (zh) | 用于治疗上呼吸道阻塞的组合物及方法 | |
JPH08512322A (ja) | H▲下2▼拮抗剤−胃腸運動性の薬剤組合せ物 | |
AU2001259458A1 (en) | Opioid antagonist compositions and dosage forms | |
RU2004107501A (ru) | Способ лечения алкоголизма или злоупотребления алкоголем | |
MXPA02003670A (es) | Sales y bases de 17-(ciclopropilmetil)-4,5 alfa-epoxi-6-metilenomorfinan-3,14 diol para optimizar la homeostasis de dopamina durante la administracion de analgesicos. | |
RU2003135201A (ru) | Применение антагониста опиоидов налтрексона для предупреждения и контроля побочных воздействий, вызванных опиоидами | |
JP2575569B2 (ja) | 薬物従属症及び禁断症状の治療に関するグリシン/nmdaレセプターリガンドの用法 | |
WO2004006929A1 (ja) | 経鼻吸収用組成物 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA93 | Acknowledgement of application withdrawn (no request for examination) |
Effective date: 20020502 |