PE20000066A1 - Formas de dosificacion solida de ribavirina administrables oralmente y proceso de fabricacion - Google Patents
Formas de dosificacion solida de ribavirina administrables oralmente y proceso de fabricacionInfo
- Publication number
- PE20000066A1 PE20000066A1 PE1998001256A PE00125698A PE20000066A1 PE 20000066 A1 PE20000066 A1 PE 20000066A1 PE 1998001256 A PE1998001256 A PE 1998001256A PE 00125698 A PE00125698 A PE 00125698A PE 20000066 A1 PE20000066 A1 PE 20000066A1
- Authority
- PE
- Peru
- Prior art keywords
- ribavirin
- manufacturing process
- dosage forms
- refers
- solid dosage
- Prior art date
Links
- IWUCXVSUMQZMFG-AFCXAGJDSA-N Ribavirin Chemical compound N1=C(C(=O)N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 IWUCXVSUMQZMFG-AFCXAGJDSA-N 0.000 title abstract 6
- 229960000329 ribavirin Drugs 0.000 title abstract 6
- HZCAHMRRMINHDJ-DBRKOABJSA-N ribavirin Natural products O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1N=CN=C1 HZCAHMRRMINHDJ-DBRKOABJSA-N 0.000 title abstract 6
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000007909 solid dosage form Substances 0.000 title 1
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 abstract 4
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 abstract 3
- WSVLPVUVIUVCRA-KPKNDVKVSA-N Alpha-lactose monohydrate Chemical compound O.O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O WSVLPVUVIUVCRA-KPKNDVKVSA-N 0.000 abstract 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 2
- 229920000168 Microcrystalline cellulose Polymers 0.000 abstract 2
- 229960001021 lactose monohydrate Drugs 0.000 abstract 2
- 235000019359 magnesium stearate Nutrition 0.000 abstract 2
- 239000008108 microcrystalline cellulose Substances 0.000 abstract 2
- 235000019813 microcrystalline cellulose Nutrition 0.000 abstract 2
- 229940016286 microcrystalline cellulose Drugs 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 239000011734 sodium Substances 0.000 abstract 2
- 229910052708 sodium Inorganic materials 0.000 abstract 2
- 208000006154 Chronic hepatitis C Diseases 0.000 abstract 1
- 229920002261 Corn starch Polymers 0.000 abstract 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 abstract 1
- AEMRFAOFKBGASW-UHFFFAOYSA-M Glycolate Chemical compound OCC([O-])=O AEMRFAOFKBGASW-UHFFFAOYSA-M 0.000 abstract 1
- 208000005176 Hepatitis C Diseases 0.000 abstract 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 abstract 1
- 229930195725 Mannitol Natural products 0.000 abstract 1
- -1 SUCROSA Chemical compound 0.000 abstract 1
- 229920002472 Starch Polymers 0.000 abstract 1
- 239000003443 antiviral agent Substances 0.000 abstract 1
- CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical compound [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 abstract 1
- 239000008116 calcium stearate Substances 0.000 abstract 1
- 235000013539 calcium stearate Nutrition 0.000 abstract 1
- 239000002775 capsule Substances 0.000 abstract 1
- 238000005056 compaction Methods 0.000 abstract 1
- 239000008120 corn starch Substances 0.000 abstract 1
- 239000007884 disintegrant Substances 0.000 abstract 1
- 239000000945 filler Substances 0.000 abstract 1
- 208000010710 hepatitis C virus infection Diseases 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 229960001375 lactose Drugs 0.000 abstract 1
- 239000008101 lactose Substances 0.000 abstract 1
- 239000000314 lubricant Substances 0.000 abstract 1
- 239000000594 mannitol Substances 0.000 abstract 1
- 235000010355 mannitol Nutrition 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 abstract 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 abstract 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 229940080313 sodium starch Drugs 0.000 abstract 1
- 235000019698 starch Nutrition 0.000 abstract 1
- 239000000454 talc Substances 0.000 abstract 1
- 229910052623 talc Inorganic materials 0.000 abstract 1
- XOOUIPVCVHRTMJ-UHFFFAOYSA-L zinc stearate Chemical compound [Zn+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O XOOUIPVCVHRTMJ-UHFFFAOYSA-L 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4833—Encapsulating processes; Filling of capsules
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/997,169 US5916594A (en) | 1997-12-22 | 1997-12-22 | Process of making solid ribavirin dosage forms |
| US08/997,172 US5914128A (en) | 1997-12-22 | 1997-12-22 | Orally administrable solid dosage form |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20000066A1 true PE20000066A1 (es) | 2000-02-09 |
Family
ID=27130673
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE1998001256A PE20000066A1 (es) | 1997-12-22 | 1998-12-21 | Formas de dosificacion solida de ribavirina administrables oralmente y proceso de fabricacion |
Country Status (26)
| Country | Link |
|---|---|
| US (3) | US6337090B1 (enExample) |
| EP (2) | EP0991415B1 (enExample) |
| JP (2) | JP2001526234A (enExample) |
| KR (1) | KR100575389B1 (enExample) |
| CN (1) | CN1155388C (enExample) |
| AR (1) | AR008977A1 (enExample) |
| AT (1) | ATE234103T1 (enExample) |
| AU (1) | AU762826B2 (enExample) |
| BR (1) | BR9814367A (enExample) |
| CA (4) | CA2365412C (enExample) |
| CO (1) | CO4970774A1 (enExample) |
| DE (1) | DE69812094T2 (enExample) |
| DK (1) | DK0991415T3 (enExample) |
| ES (1) | ES2191987T3 (enExample) |
| HU (1) | HUP0100433A3 (enExample) |
| IL (1) | IL136549A (enExample) |
| MY (1) | MY119656A (enExample) |
| NO (1) | NO20003234L (enExample) |
| NZ (1) | NZ504994A (enExample) |
| PE (1) | PE20000066A1 (enExample) |
| PL (1) | PL190267B1 (enExample) |
| PT (1) | PT991415E (enExample) |
| SK (1) | SK284520B6 (enExample) |
| TW (1) | TW575436B (enExample) |
| WO (1) | WO1999032128A1 (enExample) |
| ZA (1) | ZA9811726B (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE234103T1 (de) * | 1997-12-22 | 2003-03-15 | Schering Corp | Feste, oral verabreichbare ribavirin dosisformen und verfahren zu deren herstellung |
| US6793934B1 (en) * | 1999-12-08 | 2004-09-21 | Shire Laboratories, Inc. | Solid oral dosage form |
| EP1263341B1 (en) * | 2000-03-06 | 2008-06-11 | Salient Surgical Technologies, Inc. | Fluid delivery system and controller for electrosurgical devices |
| US6720000B2 (en) * | 2001-03-19 | 2004-04-13 | Three Rivers Pharmaceutical, Llc | Process for producing wet ribavirin pellets |
| KR20030020137A (ko) * | 2001-09-03 | 2003-03-08 | 진양제약주식회사 | 리바비린 건조시럽제 |
| RU2004116821A (ru) * | 2001-11-02 | 2005-04-20 | Сандоз Инк. (Us) | Способ получения быстрорастворимой композиции с высоким содержанием рибавирина |
| DE10227148A1 (de) * | 2002-06-18 | 2004-01-08 | Biopartners Gmbh | Verwendung von Ribavirin zur Herstellung einer pharmazeutischen Zusammensetzung gegen Bunyaviridae |
| US7538094B2 (en) * | 2002-09-19 | 2009-05-26 | Three Rivers Pharmacueticals, Llc | Composition containing ribavirin and use thereof |
| US20040142903A1 (en) * | 2003-01-16 | 2004-07-22 | Par Pharmaceutical Inc. | Bioavailable fenofibrate compositions, methods for treating hyperlipidemia and hypercholesterolemia and processes for the preparation of such compositions |
| CN1980678A (zh) * | 2003-03-28 | 2007-06-13 | 法莫赛特股份有限公司 | 治疗黄病毒感染的化合物 |
| TR200701424T1 (tr) * | 2004-09-09 | 2007-04-24 | Bayer Healthcare Ag | Suda çözünebilen katı dozaj formunda farmasötik bileşim. |
| US7723310B2 (en) * | 2004-10-18 | 2010-05-25 | Three Rivers Pharmaceuticals, Llc | Large dose ribavirin formulations |
| US8062670B2 (en) * | 2005-08-05 | 2011-11-22 | 3M Innovative Properties Company | Compositions exhibiting improved flowability |
| EP2054076A2 (en) * | 2006-08-21 | 2009-05-06 | United Therapeutics Corporation | Combination therapy for treatment of viral infections |
| WO2009142852A2 (en) * | 2008-05-22 | 2009-11-26 | 3M Innovative Properties Company | Process for manufacturing flowable powder drug compositions |
| WO2009158300A1 (en) * | 2008-06-26 | 2009-12-30 | 3M Innovative Properties Company | Dry powder pharmaceutical compositions for pulmonary administration, and methods of manufacturing thereof |
| EP2309984B1 (en) * | 2008-07-02 | 2018-04-11 | 3M Innovative Properties Company | Method of making a dry powder pharmaceutical composition |
| EP2295037A1 (en) | 2009-09-11 | 2011-03-16 | Ratiopharm GmbH | Pharmaceutical formulation containing Ribavirin |
| US10363453B2 (en) | 2011-02-07 | 2019-07-30 | New Balance Athletics, Inc. | Systems and methods for monitoring athletic and physiological performance |
| CA2752008A1 (en) | 2011-09-13 | 2013-03-13 | Universite De Montreal | Combination therapy using ribavirin as elf4e inhibitor |
| CN106389363A (zh) * | 2016-10-18 | 2017-02-15 | 广东肇庆星湖生物科技股份有限公司 | 一种利巴韦林口服固体制剂及其制备方法 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| DE1228029C2 (de) * | 1964-05-09 | 1973-05-17 | Merck Ag E | Verfahren zur Herstellung von Tabletten durch Pressen von Pulvergemischen ohne vorhergehende Granulation |
| US3490742A (en) * | 1966-01-14 | 1970-01-20 | Staley Mfg Co A E | Compressed tablets |
| US3622677A (en) * | 1969-07-07 | 1971-11-23 | Staley Mfg Co A E | Compressed tablets containing compacted starch as binder-disintegrant ingredient |
| US4211771A (en) * | 1971-06-01 | 1980-07-08 | Robins Ronald K | Treatment of human viral diseases with 1-B-D-ribofuranosyl-1,2,4-triazole-3-carboxamide |
| DE2735600A1 (de) * | 1977-08-06 | 1979-02-15 | Dynamit Nobel Ag | Verfahren zur herstellung von phthalid |
| JPS57146593A (en) * | 1981-03-09 | 1982-09-10 | Ajinomoto Co Inc | Preparation of ribofuranosyltriazole derivative |
| US4609675A (en) * | 1984-08-17 | 1986-09-02 | The Upjohn Company | Stable, high dose, high bulk density ibuprofen granulations for tablet and capsule manufacturing |
| US4681765A (en) * | 1984-09-13 | 1987-07-21 | American Home Products Corporation | Rapid releasing triamterene containing gelatin capsule dosage forms for once daily antihypertensive use |
| US5077279A (en) * | 1986-05-01 | 1991-12-31 | University Of Georgia Research Foundation, Inc. | 3'-azido-2',3'-dideoxy-5-methylcytidine anti-viral composition |
| US5084445A (en) * | 1986-05-01 | 1992-01-28 | University Of Georgia Research Foundation, Inc. | 3'-azido-2',3'-dideoxy-5-methylcytidine |
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| JPS63216820A (ja) * | 1987-03-05 | 1988-09-09 | Chugai Pharmaceut Co Ltd | 抗ウイルス剤 |
| GB8800276D0 (en) * | 1988-01-07 | 1988-02-10 | Univ Liverpool | Medical treatment |
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| US5192788A (en) * | 1988-05-23 | 1993-03-09 | Georgia State University Foundation, Inc. | Porphyrin antiviral compositions |
| US5109016A (en) * | 1988-05-23 | 1992-04-28 | Georgia State University Foundation, Inc. | Method for inhibiting infection or replication of human immunodeficiency virus with porphyrin and phthalocyanine antiviral compositions |
| NZ229453A (en) * | 1988-06-10 | 1991-08-27 | Univ Minnesota & Southern Rese | A pharmaceutical composition containing purine derivatives with nucleosides such as azt, as antiviral agents |
| US5122517A (en) * | 1988-06-10 | 1992-06-16 | Regents Of The University Of Minnesota | Antiviral combination comprising nucleoside analogs |
| JP2908844B2 (ja) * | 1990-06-29 | 1999-06-21 | ヤマサ醤油株式会社 | 抗ウイルス剤 |
| JPH07502740A (ja) * | 1992-01-06 | 1995-03-23 | ザ・ウエルカム・ファウンデーション・リミテッド | 治療用ヌクレオシド |
| US5869097A (en) * | 1992-11-02 | 1999-02-09 | Alza Corporation | Method of therapy comprising an osmotic caplet |
| US5358721A (en) * | 1992-12-04 | 1994-10-25 | Alza Corporation | Antiviral therapy |
| JPH06298665A (ja) * | 1993-04-14 | 1994-10-25 | Toray Ind Inc | 抗ウイルス剤 |
| US5506248A (en) * | 1993-08-02 | 1996-04-09 | Bristol-Myers Squibb Company | Pharmaceutical compositions having good dissolution properties |
| US5492692A (en) * | 1993-08-17 | 1996-02-20 | University Of Kentucky Research Foundation | Coated products with potent anti-HIV and antimicrobial properties |
| US5370878A (en) * | 1993-09-30 | 1994-12-06 | Hallmark Pharmaceuticals, Inc. | Method for preparing a direct compression granulated acetaminophen composition |
| US5605889A (en) * | 1994-04-29 | 1997-02-25 | Pfizer Inc. | Method of administering azithromycin |
| CA2135669A1 (en) | 1994-11-10 | 1996-05-11 | Nils O. Johannesson | Ribavirin as hepato (liver) protecting agent |
| IL116674A (en) * | 1995-01-09 | 2003-05-29 | Mendell Co Inc Edward | Microcrystalline cellulose-based excipient having improved compressibility, pharmaceutical compositions containing the same and methods for the preparation of said excipient and of solid dosage form thereof |
| US5948438A (en) * | 1995-01-09 | 1999-09-07 | Edward Mendell Co., Inc. | Pharmaceutical formulations having improved disintegration and/or absorptivity |
| US6106865A (en) * | 1995-01-09 | 2000-08-22 | Edward Mendell Co., Inc. | Pharmaceutical excipient having improved compressibility |
| US5585115A (en) * | 1995-01-09 | 1996-12-17 | Edward H. Mendell Co., Inc. | Pharmaceutical excipient having improved compressability |
| CA2213700C (en) * | 1995-02-28 | 2002-04-02 | Hoechst Marion Roussel, Inc. | Pharmaceutical composition for piperidinoalkanol compounds |
| US6387365B1 (en) * | 1995-05-19 | 2002-05-14 | Schering Corporation | Combination therapy for chronic hepatitis C infection |
| US5733578A (en) * | 1995-11-15 | 1998-03-31 | Edward Mendell Co., Inc. | Directly compressible high load acetaminophen formulations |
| US5723589A (en) * | 1995-12-21 | 1998-03-03 | Icn Pharmaceuticals | Carbohydrate conjugated bio-active compounds |
| IT1282650B1 (it) * | 1996-02-19 | 1998-03-31 | Jagotec Ag | Compressa farmaceutica,caratterizzata da elevato aumento di volume a contatto con liquidi biologici |
| US6172046B1 (en) * | 1997-09-21 | 2001-01-09 | Schering Corporation | Combination therapy for eradicating detectable HCV-RNA in patients having chronic Hepatitis C infection |
| US5914128A (en) * | 1997-12-22 | 1999-06-22 | Schering Corporation | Orally administrable solid dosage form |
| US5916594A (en) * | 1997-12-22 | 1999-06-29 | Schering Corporation | Process of making solid ribavirin dosage forms |
| ATE234103T1 (de) * | 1997-12-22 | 2003-03-15 | Schering Corp | Feste, oral verabreichbare ribavirin dosisformen und verfahren zu deren herstellung |
-
1998
- 1998-12-21 AT AT98965983T patent/ATE234103T1/de active
- 1998-12-21 HU HU0100433A patent/HUP0100433A3/hu unknown
- 1998-12-21 AR ARP980106567A patent/AR008977A1/es unknown
- 1998-12-21 CA CA002365412A patent/CA2365412C/en not_active Expired - Fee Related
- 1998-12-21 BR BR9814367-0A patent/BR9814367A/pt not_active Application Discontinuation
- 1998-12-21 PT PT98965983T patent/PT991415E/pt unknown
- 1998-12-21 DE DE69812094T patent/DE69812094T2/de not_active Expired - Lifetime
- 1998-12-21 NZ NZ504994A patent/NZ504994A/xx unknown
- 1998-12-21 EP EP98965983A patent/EP0991415B1/en not_active Expired - Lifetime
- 1998-12-21 DK DK98965983T patent/DK0991415T3/da active
- 1998-12-21 KR KR1020007006927A patent/KR100575389B1/ko not_active Expired - Fee Related
- 1998-12-21 SK SK894-2000A patent/SK284520B6/sk not_active IP Right Cessation
- 1998-12-21 PL PL98341230A patent/PL190267B1/pl not_active IP Right Cessation
- 1998-12-21 MY MYPI98005792A patent/MY119656A/en unknown
- 1998-12-21 AU AU21991/99A patent/AU762826B2/en not_active Ceased
- 1998-12-21 CA CA002287056A patent/CA2287056C/en not_active Expired - Fee Related
- 1998-12-21 WO PCT/US1998/026222 patent/WO1999032128A1/en not_active Ceased
- 1998-12-21 CA CA002300452A patent/CA2300452C/en not_active Expired - Fee Related
- 1998-12-21 ZA ZA9811726A patent/ZA9811726B/xx unknown
- 1998-12-21 IL IL13654998A patent/IL136549A/xx not_active IP Right Cessation
- 1998-12-21 CN CNB988124858A patent/CN1155388C/zh not_active Expired - Fee Related
- 1998-12-21 CA CA002323849A patent/CA2323849C/en not_active Expired - Fee Related
- 1998-12-21 US US09/582,060 patent/US6337090B1/en not_active Expired - Fee Related
- 1998-12-21 PE PE1998001256A patent/PE20000066A1/es not_active Application Discontinuation
- 1998-12-21 ES ES98965983T patent/ES2191987T3/es not_active Expired - Lifetime
- 1998-12-21 JP JP2000525119A patent/JP2001526234A/ja active Pending
- 1998-12-21 EP EP02023032A patent/EP1321147A1/en not_active Withdrawn
- 1998-12-22 CO CO98075938A patent/CO4970774A1/es unknown
- 1998-12-24 TW TW87121436A patent/TW575436B/zh not_active IP Right Cessation
-
1999
- 1999-05-07 US US09/307,008 patent/US6051252A/en not_active Expired - Fee Related
-
2000
- 2000-03-06 US US09/518,871 patent/US6335032B1/en not_active Expired - Fee Related
- 2000-06-21 NO NO20003234A patent/NO20003234L/no not_active Application Discontinuation
-
2005
- 2005-12-12 JP JP2005358349A patent/JP2006083189A/ja active Pending
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