PE20040104A1 - Composicion farmaceutica que tiene una distribucion y potencia uniforme de farmaco - Google Patents

Composicion farmaceutica que tiene una distribucion y potencia uniforme de farmaco

Info

Publication number
PE20040104A1
PE20040104A1 PE2003000682A PE2003000682A PE20040104A1 PE 20040104 A1 PE20040104 A1 PE 20040104A1 PE 2003000682 A PE2003000682 A PE 2003000682A PE 2003000682 A PE2003000682 A PE 2003000682A PE 20040104 A1 PE20040104 A1 PE 20040104A1
Authority
PE
Peru
Prior art keywords
weight
potency
sodium
propharmac
active ingredient
Prior art date
Application number
PE2003000682A
Other languages
English (en)
Inventor
Daniel Scott Gierer
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of PE20040104A1 publication Critical patent/PE20040104A1/es

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/205Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/28Dragees; Coated pills or tablets, e.g. with film or compression coating
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/08Drugs for disorders of the urinary system of the prostate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/24Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30Oestrogens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2013Organic compounds, e.g. phospholipids, fats
    • A61K9/2018Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/28Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806Coating materials
    • A61K9/2833Organic macromolecular compounds
    • A61K9/286Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841Filling excipients; Inactive ingredients
    • A61K9/4858Organic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841Filling excipients; Inactive ingredients
    • A61K9/4866Organic macromolecular compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

QUE COMPRENDE: 1)UN NUCLEO DE COMPRIMIDO O RELLENO DE CAPSULAS, QUE A SU VEZ COMPRENDE: a)COMO INGREDIENTE ACTIVO 0,3% A 14%, EN PESO, DE (-)-CIS-6-FENIL-5-[4-(2-PIRROLIDIN-1-IL-ETOXI)FENIL]-5,6,7,8-TETRAHIDRONAFTALEN-2-OL; b)UN PROFARMACO DE (a) O UNA SAL, HIDRATO O SOLVATO FARMACEUTICAMENTE ACEPTABLE DEL COMPUESTO O DEL PROFARMACO; 2)3%, EN PESO, DE UN DISGREGANTE, SELECCIONADO DE: GLICOLATO SODICO DE ALMIDON, CARBOXIMETIL-CELULOSA SODICA, POLACRILINA POTASICA, CROSCARMELOSA SODICA, ENTRE OTROS; 3)0,5%, EN PESO, DE UN DESLIZANTE, SELECCIONADO DE DIOXIDO DE SILICIO, TALCO Y ALMIDON DE MAIZ; 4)1%,EN PESO DE UN LUBRICANTE, SELECCIONADO DE ESTEARATO DE CALCIO, MONOESTEARATO DE GLICERILO, PALMITOESTEARATO, ESTEARATO DE MAGNESIO, ENTRE OTROS; Y, 5)81% A 95%, EN PESO, APROXIMADAMENTE DE UN DILUYENTE/CARGA, SELECCIONADO DE: LACTOSA, MANITOL, XILITOL, DEXTROSA, SACAROSA, SORBITOL, CELULOSA MICROCRISTALINA, ENTRE OTROS. LA COMPOSICION DESCRITA TIENEN UNA DISTRIBUCION Y POTENCIA DE LASOFOXIFENO UNIFORME Y UTILIZA EL DIOXIDO DE SILICIO PARA REDUCIR LA PERDIDA DE INGREDIENTE ACTIVO
PE2003000682A 2002-07-10 2003-07-07 Composicion farmaceutica que tiene una distribucion y potencia uniforme de farmaco PE20040104A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US39509002P 2002-07-10 2002-07-10

Publications (1)

Publication Number Publication Date
PE20040104A1 true PE20040104A1 (es) 2004-02-27

Family

ID=30115812

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2003000682A PE20040104A1 (es) 2002-07-10 2003-07-07 Composicion farmaceutica que tiene una distribucion y potencia uniforme de farmaco

Country Status (36)

Country Link
US (2) US20040057992A1 (es)
EP (1) EP1534248B1 (es)
JP (2) JP4446446B2 (es)
KR (1) KR100782693B1 (es)
CN (1) CN100344278C (es)
AP (1) AP2005003201A0 (es)
AR (1) AR040434A1 (es)
AT (1) ATE550017T1 (es)
AU (1) AU2003247017B2 (es)
BR (1) BR0312563A (es)
CA (1) CA2489407C (es)
CY (1) CY1112892T1 (es)
DK (1) DK1534248T3 (es)
EA (1) EA007268B1 (es)
EC (1) ECSP055528A (es)
ES (1) ES2395123T3 (es)
HK (1) HK1077747A1 (es)
HN (1) HN2003000206A (es)
HR (1) HRP20041196A2 (es)
IL (2) IL165746A0 (es)
IS (1) IS7594A (es)
MA (1) MA27318A1 (es)
MX (1) MXPA05000394A (es)
NO (1) NO20050018L (es)
NZ (1) NZ537278A (es)
OA (1) OA12883A (es)
PA (1) PA8576201A1 (es)
PE (1) PE20040104A1 (es)
PL (1) PL374913A1 (es)
PT (1) PT1534248E (es)
SI (1) SI1534248T1 (es)
TN (1) TNSN05006A1 (es)
TW (1) TW200406222A (es)
UY (1) UY27886A1 (es)
WO (1) WO2004006895A1 (es)
ZA (1) ZA200410196B (es)

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PA8576201A1 (es) * 2002-07-10 2004-05-26 Pfizer Prod Inc Composicion farmaceutica que tiene una distribucion y potencia uniforme de farmaco
US20040253305A1 (en) * 2003-06-12 2004-12-16 Luner Paul E. Pharmaceutical compositions of atorvastatin
US20050271717A1 (en) * 2003-06-12 2005-12-08 Alfred Berchielli Pharmaceutical compositions of atorvastatin
EP1871359A1 (en) * 2005-04-07 2008-01-02 Miso Sabovic Delaying the ageing process and disorders caused by ageing
WO2006118137A1 (ja) * 2005-04-26 2006-11-09 Dainippon Sumitomo Pharma Co., Ltd. ビグアナイド系薬物を含有する粒状製剤
GB0516604D0 (en) * 2005-08-12 2005-09-21 Sandoz Ag Rapidly dispersing/disintegrating compositions
EP3173084B1 (en) 2005-11-11 2019-10-23 Boehringer Ingelheim International GmbH Quinazoline derivatives for the treatment of cancer diseases
LT2487166T (lt) 2007-02-23 2016-11-10 Gilead Sciences, Inc. Terapinių agentų farmakokinetinių savybių moduliatoriai
CA2835910C (en) * 2007-04-25 2016-06-28 Warner Chilcott Company, Llc Improved vitamin d content uniformity in pharmaceutical dosage forms
US20100055180A1 (en) * 2007-10-10 2010-03-04 Mallinckrodt Baker, Inc. Directly Compressible Granular Microcrystalline Cellulose Based Excipient, Manufacturing Process and Use Thereof
CN101820863A (zh) * 2007-10-10 2010-09-01 马林克罗特贝克公司 直接可压制的高功能性颗粒状微晶纤维素基赋形剂、其制备方法和用途
WO2009135067A1 (en) * 2008-05-01 2009-11-05 Wyeth Pharmaceutical polish formulations
SG190618A1 (en) * 2008-05-02 2013-06-28 Gilead Sciences Inc The use of solid carrier particles to improve the processability of a pharmaceutical agent
US9545381B2 (en) * 2009-07-06 2017-01-17 Boehringer Ingelheim International Gmbh Process for drying of BIBW2992, of its salts and of solid pharmaceutical formulations comprising this active ingredient
RU2661402C2 (ru) * 2011-10-17 2018-07-16 Лексикон Фармасьютикалз, Инк. Твердые дозированные формы (s)-этил 2-амино-3-(4-(2-амино-6((r)-1-(4-хлор-2-(3-метил-1н-пиразол-1-ил)фенил)-2,2,2-трифторэтокси)пиримидин-4-ил)фенил)пропаноата
DK2851075T3 (da) 2012-05-14 2022-01-31 Shionogi & Co Præparat, der indeholder 6,7-umættet -7-carbamoylmorphinanderivat
PL3043778T3 (pl) * 2013-09-13 2018-04-30 Bayer Pharma Aktiengesellschaft Kompozycje farmaceutyczne zawierające refametinib
RU2539375C1 (ru) * 2013-11-07 2015-01-20 Общество С Ограниченной Ответственностью "Валента-Интеллект" Фармацевтическая композиция в форме таблетки и способ ее получения
US9242965B2 (en) 2013-12-31 2016-01-26 Boehringer Ingelheim International Gmbh Process for the manufacture of (E)-4-N,N-dialkylamino crotonic acid in HX salt form and use thereof for synthesis of EGFR tyrosine kinase inhibitors
CN103830196A (zh) * 2014-03-14 2014-06-04 王志刚 一种酒石酸拉索昔芬分散片及其制备方法
TWI535784B (zh) 2014-08-26 2016-06-01 財團法人工業技術研究院 剪切增稠配方、及包含其之複合材料
CN105434444B (zh) * 2014-09-29 2021-02-05 上海奥奇医药科技有限公司 一种A-失碳-5α雄甾烷化合物的口服制剂
US20190183850A1 (en) * 2016-07-25 2019-06-20 Canopy Growth Corporation New cannabis tablet formulations and compositions and methods of making the same
JP6892151B2 (ja) 2016-10-11 2021-06-23 デューク ユニバーシティ Er+乳がんのラソフォキシフェン処置
EP3773524A4 (en) 2018-04-10 2021-12-22 Duke University TREATMENT OF BREAST CANCER WITH LASOFOXIFEN
GB202116903D0 (en) 2021-11-18 2022-01-05 Sermonix Pharmaceuticals Inc Lasofoxifene treatment of aromatase-resistant er+ cancer
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PA8576201A1 (es) * 2002-07-10 2004-05-26 Pfizer Prod Inc Composicion farmaceutica que tiene una distribucion y potencia uniforme de farmaco

Also Published As

Publication number Publication date
OA12883A (en) 2006-09-15
EA200401583A1 (ru) 2005-06-30
PA8576201A1 (es) 2004-05-26
HK1077747A1 (en) 2006-02-24
MXPA05000394A (es) 2005-03-23
PL374913A1 (en) 2005-11-14
ECSP055528A (es) 2005-03-10
DK1534248T3 (da) 2012-06-25
MA27318A1 (fr) 2005-05-02
SI1534248T1 (sl) 2012-07-31
NZ537278A (en) 2007-07-27
EP1534248B1 (en) 2012-03-21
CY1112892T1 (el) 2016-04-13
IL165746A (en) 2008-12-29
US20040057992A1 (en) 2004-03-25
TW200406222A (en) 2004-05-01
JP2005535671A (ja) 2005-11-24
CA2489407A1 (en) 2004-01-22
AU2003247017B2 (en) 2008-03-06
IL165746A0 (en) 2006-01-15
NO20050018L (no) 2005-01-12
ES2395123T3 (es) 2013-02-08
ZA200410196B (en) 2006-07-26
WO2004006895A1 (en) 2004-01-22
CN1668285A (zh) 2005-09-14
AR040434A1 (es) 2005-04-06
EP1534248A1 (en) 2005-06-01
PT1534248E (pt) 2012-05-25
AP2005003201A0 (en) 2005-03-31
US20070110800A1 (en) 2007-05-17
JP4446446B2 (ja) 2010-04-07
KR100782693B1 (ko) 2007-12-07
US7553500B2 (en) 2009-06-30
ATE550017T1 (de) 2012-04-15
CN100344278C (zh) 2007-10-24
AU2003247017A1 (en) 2004-02-02
CA2489407C (en) 2009-01-27
IS7594A (is) 2004-12-13
KR20050017102A (ko) 2005-02-21
JP2007031451A (ja) 2007-02-08
EA007268B1 (ru) 2006-08-25
TNSN05006A1 (fr) 2007-05-14
UY27886A1 (es) 2004-02-27
HN2003000206A (es) 2004-07-27
HRP20041196A2 (en) 2005-04-30
BR0312563A (pt) 2005-04-19

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