ITRM20010294A1 - Uso della acetil l-carnetina in associazione con la biotina per il trattamento di pazienti affetti da diabete mellito di tipo ii insulino re - Google Patents
Uso della acetil l-carnetina in associazione con la biotina per il trattamento di pazienti affetti da diabete mellito di tipo ii insulino reInfo
- Publication number
- ITRM20010294A1 ITRM20010294A1 IT2001RM000294A ITRM20010294A ITRM20010294A1 IT RM20010294 A1 ITRM20010294 A1 IT RM20010294A1 IT 2001RM000294 A IT2001RM000294 A IT 2001RM000294A IT RM20010294 A ITRM20010294 A IT RM20010294A IT RM20010294 A1 ITRM20010294 A1 IT RM20010294A1
- Authority
- IT
- Italy
- Prior art keywords
- biotin
- insulin
- acetyl
- patients
- association
- Prior art date
Links
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 title abstract 4
- 229960002685 biotin Drugs 0.000 title abstract 2
- 235000020958 biotin Nutrition 0.000 title abstract 2
- 239000011616 biotin Substances 0.000 title abstract 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title 2
- 102000004877 Insulin Human genes 0.000 title 1
- 108090001061 Insulin Proteins 0.000 title 1
- 125000002777 acetyl group Chemical class [H]C([H])([H])C(*)=O 0.000 title 1
- 206010012601 diabetes mellitus Diseases 0.000 title 1
- 229940125396 insulin Drugs 0.000 title 1
- 206010022491 Insulin resistant diabetes Diseases 0.000 abstract 1
- RDHQFKQIGNGIED-MRVPVSSYSA-N O-acetyl-L-carnitine Chemical compound CC(=O)O[C@H](CC([O-])=O)C[N+](C)(C)C RDHQFKQIGNGIED-MRVPVSSYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/221—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having an amino group, e.g. acetylcholine, acetylcarnitine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Endocrinology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (19)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2001RM000294A ITRM20010294A1 (it) | 2001-05-29 | 2001-05-29 | Uso della acetil l-carnetina in associazione con la biotina per il trattamento di pazienti affetti da diabete mellito di tipo ii insulino re |
| SK1585-2003A SK287832B6 (sk) | 2001-05-29 | 2002-05-24 | Use of acetyl L-carnitine in association with biotin for the treatment of patients with Type 2 insulin-resistant diabetes mellitus. |
| CZ20033221A CZ297743B6 (cs) | 2001-05-29 | 2002-05-24 | Pouzití acetyl-L-karnitinu ve spojení s biotinem k lécbe pacientu s diabetem mellitus typu 2 rezistentním na inzulín |
| EP02741155A EP1399142B1 (en) | 2001-05-29 | 2002-05-24 | Use of acetyl l-carnitine in association with the biotin for the treatment of patients with type 2 insulin-resistant diabetes mellitus |
| US10/478,372 US20040142879A1 (en) | 2001-05-29 | 2002-05-24 | Use of the acetyl l-carnitine in association with the biotin for the treatment of patients with type 2 insulin-resistant diabetes mellitus |
| PT02741155T PT1399142E (pt) | 2001-05-29 | 2002-05-24 | Utilizacao de acetil-l-carnitina em associacao com biotina para o tratamento de doentes com diabetes mellitus insulino-resistente do tipo 2 |
| CA2448244A CA2448244C (en) | 2001-05-29 | 2002-05-24 | Use of the acetyl l-carnitine in association with the biotin for the treatment of patients with type 2 insulin-resistant diabetes mellitus |
| ES02741155T ES2268053T3 (es) | 2001-05-29 | 2002-05-24 | Uso de acetil l-carnitina en asociacion con biotina para el tratamiento de pacientes con diabetes mellitus de tipo 2 resistente a insulina. |
| JP2002592920A JP4381685B2 (ja) | 2001-05-29 | 2002-05-24 | ２型インスリン抵抗性真性糖尿病患者の治療のためのビオチンと組合せてのアセチルｌ−カルニチンの使用 |
| AT02741155T ATE333274T1 (de) | 2001-05-29 | 2002-05-24 | Verwendung von l-acetylcarnitin in kombination mit biotin zur behandlung von patienten mit insulinresistentem diabetes mellitus typ ii |
| DK02741155T DK1399142T3 (da) | 2001-05-29 | 2002-05-24 | Anvendelse af acetyl-L-carnitin i kombination med biotin til behandlingen af patienter med type-2 insulinresistent diabetes mellitus |
| KR10-2003-7015575A KR20040010666A (ko) | 2001-05-29 | 2002-05-24 | ２ 형 인슐린 내성 당뇨병 환자의 치료를 위한 비오틴과회합된 아세틸 ｌ-카르니틴의 용도 |
| DE60213237T DE60213237T2 (de) | 2001-05-29 | 2002-05-24 | Verwendung von l-acetylcarnitin in kombination mit biotin zur behandlung von patienten mit insulinresistentem diabetes mellitus typ ii |
| HU0400060A HUP0400060A2 (hu) | 2001-05-29 | 2002-05-24 | Acetil-L-karnitin alkalmazása biotinnal együtt, II típusú, inzulinrezisztens diabétesz mellituszban szenvedő betegek kezelésére |
| PL367630A PL207522B1 (pl) | 2001-05-29 | 2002-05-24 | Zastosowanie acetylo-L-karnityny w połączeniu z biotyną |
| PCT/IT2002/000338 WO2002096410A1 (en) | 2001-05-29 | 2002-05-24 | Use of the acetyl l-carnitine in association with the biotin for the treatment of patients with type 2 insulin-resistant diabetes mellitus |
| MXPA03010921A MXPA03010921A (es) | 2001-05-29 | 2002-05-24 | Uso de acetil l-carnitina en asociacion con biotina para tratamiento der pacientes con diabetes mellitus resistente a insulina tipo 2. |
| CY20061101375T CY1105403T1 (el) | 2001-05-29 | 2006-09-25 | Χρηση της ακετυλο-l-καρνιτινης σε συνδυασμο με τη βιοτινη για τη θepαπεια ασθενων με ινσουλινο-ανθεκτικο σακχαρωδη διαβητη τυπου 2 |
| US12/216,279 US8053472B2 (en) | 2001-05-29 | 2008-07-02 | Use of the acetyl L-carnitine in association with the biotin for the treatment of patients with type 2 insulin-resistant diabetes mellitus |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2001RM000294A ITRM20010294A1 (it) | 2001-05-29 | 2001-05-29 | Uso della acetil l-carnetina in associazione con la biotina per il trattamento di pazienti affetti da diabete mellito di tipo ii insulino re |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ITRM20010294A0 ITRM20010294A0 (it) | 2001-05-29 |
| ITRM20010294A1 true ITRM20010294A1 (it) | 2002-11-29 |
Family
ID=11455558
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT2001RM000294A ITRM20010294A1 (it) | 2001-05-29 | 2001-05-29 | Uso della acetil l-carnetina in associazione con la biotina per il trattamento di pazienti affetti da diabete mellito di tipo ii insulino re |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US20040142879A1 (enExample) |
| EP (1) | EP1399142B1 (enExample) |
| JP (1) | JP4381685B2 (enExample) |
| KR (1) | KR20040010666A (enExample) |
| AT (1) | ATE333274T1 (enExample) |
| CA (1) | CA2448244C (enExample) |
| CY (1) | CY1105403T1 (enExample) |
| CZ (1) | CZ297743B6 (enExample) |
| DE (1) | DE60213237T2 (enExample) |
| DK (1) | DK1399142T3 (enExample) |
| ES (1) | ES2268053T3 (enExample) |
| HU (1) | HUP0400060A2 (enExample) |
| IT (1) | ITRM20010294A1 (enExample) |
| MX (1) | MXPA03010921A (enExample) |
| PL (1) | PL207522B1 (enExample) |
| PT (1) | PT1399142E (enExample) |
| SK (1) | SK287832B6 (enExample) |
| WO (1) | WO2002096410A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU230002B1 (en) * | 2000-12-15 | 2015-04-28 | Sigma Tau Ind Farmaceuti | Use of l-carnitine for preparation of compositions for stabilizing the proteins |
| ITRM20040327A1 (it) * | 2004-07-01 | 2004-10-01 | Sigma Tau Ind Farmaceuti | Uso della acetil l-carnitina per la preparazione di un medicamento per il trattamento del dolore neuropatico in pazienti diabetici. |
| US8569366B2 (en) | 2005-04-26 | 2013-10-29 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Acetyl L-carnitine for prevention of painful peripheral neuropathy in patients with type 2 diabetes |
| EP1832295A1 (en) * | 2006-03-10 | 2007-09-12 | Tecnogen S.P.A. | Use of PTX3 for the treatment of viral diseases |
| ES2546619T3 (es) * | 2007-03-21 | 2015-09-25 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Composición útil para la prevención de la diabetes tipo 2 y sus complicaciones en pacientes pre-diabéticos con resistencia a la insulina |
| GB201304112D0 (en) * | 2013-03-07 | 2013-04-24 | Univ Nottingham | Modulation of energy expenditure |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1196564B (it) * | 1986-08-04 | 1988-11-16 | Sigma Tau Ind Farmaceuti | Impiego di acetil l-carnitina nel trattamento terapeutico delle neuropatie periferiche |
| IT1263004B (it) * | 1992-10-08 | 1996-07-23 | Sigma Tau Ind Farmaceuti | Impiego della l-carnitina e acil l-carnitine nel trattamento a lungo termine di pazienti diabetici non insulino-dipendenti. |
| US6020139A (en) * | 1995-04-25 | 2000-02-01 | Oridigm Corporation | S-adenosyl methionine regulation of metabolic pathways and its use in diagnosis and therapy |
| US5789401A (en) * | 1997-08-08 | 1998-08-04 | Nutrition 21 | High-dose chromium/biotin treatment of type II diabetes |
-
2001
- 2001-05-29 IT IT2001RM000294A patent/ITRM20010294A1/it unknown
-
2002
- 2002-05-24 PL PL367630A patent/PL207522B1/pl not_active IP Right Cessation
- 2002-05-24 HU HU0400060A patent/HUP0400060A2/hu unknown
- 2002-05-24 WO PCT/IT2002/000338 patent/WO2002096410A1/en not_active Ceased
- 2002-05-24 ES ES02741155T patent/ES2268053T3/es not_active Expired - Lifetime
- 2002-05-24 MX MXPA03010921A patent/MXPA03010921A/es active IP Right Grant
- 2002-05-24 CA CA2448244A patent/CA2448244C/en not_active Expired - Fee Related
- 2002-05-24 CZ CZ20033221A patent/CZ297743B6/cs not_active IP Right Cessation
- 2002-05-24 US US10/478,372 patent/US20040142879A1/en not_active Abandoned
- 2002-05-24 SK SK1585-2003A patent/SK287832B6/sk not_active IP Right Cessation
- 2002-05-24 EP EP02741155A patent/EP1399142B1/en not_active Expired - Lifetime
- 2002-05-24 JP JP2002592920A patent/JP4381685B2/ja not_active Expired - Fee Related
- 2002-05-24 PT PT02741155T patent/PT1399142E/pt unknown
- 2002-05-24 DK DK02741155T patent/DK1399142T3/da active
- 2002-05-24 KR KR10-2003-7015575A patent/KR20040010666A/ko not_active Ceased
- 2002-05-24 AT AT02741155T patent/ATE333274T1/de active
- 2002-05-24 DE DE60213237T patent/DE60213237T2/de not_active Expired - Lifetime
-
2006
- 2006-09-25 CY CY20061101375T patent/CY1105403T1/el unknown
-
2008
- 2008-07-02 US US12/216,279 patent/US8053472B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DK1399142T3 (da) | 2006-10-30 |
| WO2002096410A1 (en) | 2002-12-05 |
| CZ20033221A3 (cs) | 2004-06-16 |
| KR20040010666A (ko) | 2004-01-31 |
| US20080269307A1 (en) | 2008-10-30 |
| ITRM20010294A0 (it) | 2001-05-29 |
| MXPA03010921A (es) | 2004-02-27 |
| SK15852003A3 (sk) | 2004-04-06 |
| ES2268053T3 (es) | 2007-03-16 |
| CA2448244A1 (en) | 2002-12-05 |
| US20040142879A1 (en) | 2004-07-22 |
| PT1399142E (pt) | 2006-10-31 |
| EP1399142B1 (en) | 2006-07-19 |
| CY1105403T1 (el) | 2010-04-28 |
| PL207522B1 (pl) | 2010-12-31 |
| HUP0400060A2 (hu) | 2004-04-28 |
| JP4381685B2 (ja) | 2009-12-09 |
| EP1399142A1 (en) | 2004-03-24 |
| CZ297743B6 (cs) | 2007-03-21 |
| JP2004532866A (ja) | 2004-10-28 |
| DE60213237T2 (de) | 2007-08-02 |
| DE60213237D1 (de) | 2006-08-31 |
| CA2448244C (en) | 2010-11-02 |
| ATE333274T1 (de) | 2006-08-15 |
| SK287832B6 (sk) | 2011-11-04 |
| US8053472B2 (en) | 2011-11-08 |
| PL367630A1 (en) | 2005-03-07 |
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