JP2006506361A5 - - Google Patents
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- Publication number
- JP2006506361A5 JP2006506361A5 JP2004543656A JP2004543656A JP2006506361A5 JP 2006506361 A5 JP2006506361 A5 JP 2006506361A5 JP 2004543656 A JP2004543656 A JP 2004543656A JP 2004543656 A JP2004543656 A JP 2004543656A JP 2006506361 A5 JP2006506361 A5 JP 2006506361A5
- Authority
- JP
- Japan
- Prior art keywords
- carnitine
- acid
- composition
- acidic
- phosphate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 claims 26
- 239000002253 acid Substances 0.000 claims 18
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims 16
- 238000000034 method Methods 0.000 claims 15
- 150000003839 salts Chemical class 0.000 claims 15
- 230000002378 acidificating effect Effects 0.000 claims 14
- PHIQHXFUZVPYII-ZCFIWIBFSA-N (R)-carnitine Chemical compound C[N+](C)(C)C[C@H](O)CC([O-])=O PHIQHXFUZVPYII-ZCFIWIBFSA-N 0.000 claims 12
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims 12
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims 8
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 8
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims 8
- 229940009098 aspartate Drugs 0.000 claims 8
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 claims 8
- JUUBCHWRXWPFFH-UHFFFAOYSA-N Hydroxytyrosol Chemical compound OCCC1=CC=C(O)C(O)=C1 JUUBCHWRXWPFFH-UHFFFAOYSA-N 0.000 claims 6
- 229910019142 PO4 Inorganic materials 0.000 claims 6
- 229960004203 carnitine Drugs 0.000 claims 6
- 239000010452 phosphate Substances 0.000 claims 6
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 6
- RDHQFKQIGNGIED-MRVPVSSYSA-N O-acetyl-L-carnitine Chemical compound CC(=O)O[C@H](CC([O-])=O)C[N+](C)(C)C RDHQFKQIGNGIED-MRVPVSSYSA-N 0.000 claims 5
- NDVRKEKNSBMTAX-BTVCFUMJSA-N (2r,3s,4r,5r)-2,3,4,5,6-pentahydroxyhexanal;phosphoric acid Chemical compound OP(O)(O)=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O NDVRKEKNSBMTAX-BTVCFUMJSA-N 0.000 claims 4
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 claims 4
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims 4
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims 4
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 claims 4
- UFAHZIUFPNSHSL-MRVPVSSYSA-N O-propanoyl-L-carnitine Chemical compound CCC(=O)O[C@H](CC([O-])=O)C[N+](C)(C)C UFAHZIUFPNSHSL-MRVPVSSYSA-N 0.000 claims 4
- VSNFQQXVMPSASB-SNVBAGLBSA-N O-valeroyl-L-carnitine Chemical compound CCCCC(=O)O[C@H](CC([O-])=O)C[N+](C)(C)C VSNFQQXVMPSASB-SNVBAGLBSA-N 0.000 claims 4
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 claims 4
- DTQVDTLACAAQTR-UHFFFAOYSA-M Trifluoroacetate Chemical compound [O-]C(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-M 0.000 claims 4
- AWUCVROLDVIAJX-UHFFFAOYSA-N alpha-glycerophosphate Natural products OCC(O)COP(O)(O)=O AWUCVROLDVIAJX-UHFFFAOYSA-N 0.000 claims 4
- 210000004556 brain Anatomy 0.000 claims 4
- 150000001805 chlorine compounds Chemical group 0.000 claims 4
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 claims 4
- IGQBPDJNUXPEMT-SNVBAGLBSA-N isovaleryl-L-carnitine Chemical compound CC(C)CC(=O)O[C@H](CC([O-])=O)C[N+](C)(C)C IGQBPDJNUXPEMT-SNVBAGLBSA-N 0.000 claims 4
- VNWKTOKETHGBQD-UHFFFAOYSA-N methane Chemical compound C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 claims 4
- PXQPEWDEAKTCGB-UHFFFAOYSA-N orotic acid Chemical compound OC(=O)C1=CC(=O)NC(=O)N1 PXQPEWDEAKTCGB-UHFFFAOYSA-N 0.000 claims 4
- 150000003254 radicals Chemical class 0.000 claims 4
- AWUCVROLDVIAJX-GSVOUGTGSA-N sn-glycerol 3-phosphate Chemical compound OC[C@@H](O)COP(O)(O)=O AWUCVROLDVIAJX-GSVOUGTGSA-N 0.000 claims 4
- 239000007787 solid Substances 0.000 claims 4
- 229940095064 tartrate Drugs 0.000 claims 4
- 229940095066 hydroxytyrosol Drugs 0.000 claims 3
- 235000003248 hydroxytyrosol Nutrition 0.000 claims 3
- 150000008442 polyphenolic compounds Chemical class 0.000 claims 3
- 235000013824 polyphenols Nutrition 0.000 claims 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 2
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 claims 2
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims 2
- 239000003963 antioxidant agent Substances 0.000 claims 2
- 230000006931 brain damage Effects 0.000 claims 2
- 239000002775 capsule Substances 0.000 claims 2
- 230000003683 cardiac damage Effects 0.000 claims 2
- 239000005515 coenzyme Substances 0.000 claims 2
- 235000015872 dietary supplement Nutrition 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 239000008103 glucose Substances 0.000 claims 2
- 239000008187 granular material Substances 0.000 claims 2
- 238000002347 injection Methods 0.000 claims 2
- 239000007924 injection Substances 0.000 claims 2
- 229910052500 inorganic mineral Inorganic materials 0.000 claims 2
- 208000028867 ischemia Diseases 0.000 claims 2
- 239000007788 liquid Substances 0.000 claims 2
- 208000030159 metabolic disease Diseases 0.000 claims 2
- 239000011707 mineral Substances 0.000 claims 2
- 239000011574 phosphorus Substances 0.000 claims 2
- 229910052698 phosphorus Inorganic materials 0.000 claims 2
- 239000006187 pill Substances 0.000 claims 2
- 230000010410 reperfusion Effects 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- 150000003871 sulfonates Chemical class 0.000 claims 2
- 239000006188 syrup Substances 0.000 claims 2
- 235000020357 syrup Nutrition 0.000 claims 2
- 229940066528 trichloroacetate Drugs 0.000 claims 2
- YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 claims 2
- 239000011782 vitamin Substances 0.000 claims 2
- 229940088594 vitamin Drugs 0.000 claims 2
- 229930003231 vitamin Natural products 0.000 claims 2
- 235000013343 vitamin Nutrition 0.000 claims 2
- 208000032131 Diabetic Neuropathies Diseases 0.000 claims 1
- 206010067722 Toxic neuropathy Diseases 0.000 claims 1
- 231100000126 Toxic neuropathy Toxicity 0.000 claims 1
- 238000011109 contamination Methods 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000007613 environmental effect Effects 0.000 claims 1
- 238000003912 environmental pollution Methods 0.000 claims 1
- 210000005036 nerve Anatomy 0.000 claims 1
- 230000000451 tissue damage Effects 0.000 claims 1
- 231100000827 tissue damage Toxicity 0.000 claims 1
- 230000008467 tissue growth Effects 0.000 claims 1
- 231100000331 toxic Toxicity 0.000 claims 1
- 230000002588 toxic effect Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41783802P | 2002-10-11 | 2002-10-11 | |
| PCT/US2003/032149 WO2004032873A2 (en) | 2002-10-11 | 2003-10-10 | Therapeutic combination of carnitine and antioxidant polyphenols |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006506361A JP2006506361A (ja) | 2006-02-23 |
| JP2006506361A5 true JP2006506361A5 (enExample) | 2006-11-30 |
Family
ID=32094102
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004543656A Pending JP2006506361A (ja) | 2002-10-11 | 2003-10-10 | カルニチンおよび酸化防止ポリフェノールの治療用組合せ |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20040132821A1 (enExample) |
| EP (1) | EP1558199A4 (enExample) |
| JP (1) | JP2006506361A (enExample) |
| AU (1) | AU2003279924A1 (enExample) |
| CA (1) | CA2531056A1 (enExample) |
| WO (1) | WO2004032873A2 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7115283B2 (en) * | 2003-05-06 | 2006-10-03 | Access Business Group International Llc | Preparations for sustained release of nutraceuticals and methods of controllably releasing nutraceuticals |
| JP4954450B2 (ja) * | 2004-06-14 | 2012-06-13 | ビーエーエスエフ ビューティ ケア ソリューションズ フランス エスエーエス | 弾性繊維形成の不全、欠損又は無秩序による病状に対処するための、リシルオキシダーゼのアイソフォームの活性の誘導 |
| EA011957B1 (ru) * | 2004-11-16 | 2009-06-30 | ДСМ АйПи АССЕТС Б.В. | Применение гидрокситирозола для восстановления мышц |
| JP5685362B2 (ja) * | 2005-04-26 | 2015-03-18 | シグマ−タウ・インドゥストリエ・ファルマチェウチケ・リウニテ・ソシエタ・ペル・アチオニＳｉｇｍａ−Ｔａｕ Ｉｎｄｕｓｔｒｉｅ Ｆａｒｍａｃｅｕｔｉｃｈｅ Ｒｉｕｎｉｔｅ Ｓｏｃｉｅｔａ Ｐｅｒ Ａｚｉｏｎｉ | 有痛性末梢糖尿病性神経障害の予防のためのアセチルｌ−カルニチン |
| ES2261088B1 (es) * | 2005-04-27 | 2007-12-01 | Laboratorios Alcala Farma, S.L. | Uso de hidroxitirosol en la prevencion y tratamiento del ictus cerebral isquemico. |
| RU2304964C2 (ru) * | 2005-09-26 | 2007-08-27 | Общество с ограниченной ответственностью "Экофарминвест" | Способ лечения хронической сердечной недостаточности |
| US20090163579A1 (en) * | 2005-10-14 | 2009-06-25 | Daniel Raederstorff | Novel use of nutraceutical compositions |
| WO2007088046A2 (en) | 2006-02-01 | 2007-08-09 | Nestec S.A. | Nutritional system and methods for increasing longevity |
| JP2007330191A (ja) * | 2006-06-16 | 2007-12-27 | Nihon Yobo Igaku Kenkyusho:Kk | メイラード反応を抑制する食品 |
| IT1391928B1 (it) * | 2008-08-29 | 2012-02-02 | Giellepi Chemicals S P A | Integratore alimentare per il trattamento di neuropatie |
| WO2010118789A1 (en) | 2009-04-17 | 2010-10-21 | Dsm Ip Assets B.V. | Hydroxytyrosol combinations for enhancing mitochondrial function and energy production |
| US8796315B2 (en) | 2009-06-25 | 2014-08-05 | Darlene E. McCord | Methods for improved wound closure employing olivamine and human umbilical vein endothelial cells |
| WO2010151778A2 (en) | 2009-06-25 | 2010-12-29 | Darlene Mccord | Topical compositions and methods for wound care |
| WO2011019735A2 (en) | 2009-08-10 | 2011-02-17 | Darlene Mccord | Nutritional supplements |
| WO2011109525A1 (en) * | 2010-03-02 | 2011-09-09 | Nox Technologies, Inc. | Aging-Related Circulating Particle-Associated Lipoprotein B Oxidase (apoBNOX) and Inhibitors Thereof |
| US9144555B2 (en) | 2012-11-30 | 2015-09-29 | Darlene E. McCord | Hydroxytyrosol and oleuropein compositions for induction of DNA damage, cell death and LSD1 inhibition |
| CN111343993B (zh) * | 2017-11-08 | 2024-03-29 | 雀巢产品有限公司 | 高香草醇(hva)、hva异构体、制备包含此类化合物的组合物的方法、以及使用此类化合物的方法 |
| CN113615833A (zh) * | 2021-07-01 | 2021-11-09 | 泓博元生命科技（深圳）有限公司 | 一种用于改善心血管的线粒体营养素组合物及应用 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997002041A1 (en) * | 1995-07-03 | 1997-01-23 | Crandall Wilson T | Transdermal and oral treatment of androgenic alopecia |
| IT1283967B1 (it) * | 1996-03-29 | 1998-05-07 | Sigma Tau Ind Farmaceuti | Uso di l-carnitina o derivati della l-carnitina ed antiossidanti nella prevenzione e trattamento di patologie derivanti da danni ossidativi |
| US5667791A (en) * | 1996-05-31 | 1997-09-16 | Thione International, Inc. | X-ray induced skin damage protective composition |
| US6337320B1 (en) * | 1996-10-11 | 2002-01-08 | Thione International, Inc. | Reparatives for ultraviolet radiation skin damage |
| DE19824346A1 (de) * | 1998-06-02 | 1999-12-09 | Peter Schleicher | Nahrungsergänzungsmittel |
| IT1299197B1 (it) * | 1998-06-30 | 2000-02-29 | Sigma Tau Healthscience Spa | Composizione ad attivita' antiossidante, antiproliferativa, energetica e atta a migliorare l'utilizzazione metabolica del glucosio. |
| IT1302307B1 (it) * | 1998-09-01 | 2000-09-05 | Sigma Tau Healthscience Spa | Composizione ad attivita' antiossidante ed atta a migliorarel'utilizzazione metabolica del glucosio, comprendente acetil |
| US6746706B1 (en) * | 1998-12-22 | 2004-06-08 | Lipton, Division Of Conopco, Inc. | Food compositions fortified with anti-oxidants |
| US6437004B1 (en) * | 2000-04-06 | 2002-08-20 | Nicholas V. Perricone | Treatment of skin damage using olive oil polyphenols |
| IT1317036B1 (it) * | 2000-05-30 | 2003-05-26 | Sigma Tau Healthscience Spa | Integratore ad attivita' antiossidante comprendente unaalcanoilcarnitina ed una associazione di polifenoli estratti da piante |
| JP3820218B2 (ja) * | 2000-09-01 | 2006-09-13 | クレアグリ， インコーポレイテッド | 植物水からヒドロキシチロソール富化組成物を得る方法 |
-
2003
- 2003-10-10 EP EP03773240A patent/EP1558199A4/en not_active Withdrawn
- 2003-10-10 AU AU2003279924A patent/AU2003279924A1/en not_active Abandoned
- 2003-10-10 US US10/683,803 patent/US20040132821A1/en not_active Abandoned
- 2003-10-10 JP JP2004543656A patent/JP2006506361A/ja active Pending
- 2003-10-10 WO PCT/US2003/032149 patent/WO2004032873A2/en not_active Ceased
- 2003-10-10 CA CA002531056A patent/CA2531056A1/en not_active Abandoned
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