JP2004532865A5 - - Google Patents
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- Publication number
- JP2004532865A5 JP2004532865A5 JP2002592919A JP2002592919A JP2004532865A5 JP 2004532865 A5 JP2004532865 A5 JP 2004532865A5 JP 2002592919 A JP2002592919 A JP 2002592919A JP 2002592919 A JP2002592919 A JP 2002592919A JP 2004532865 A5 JP2004532865 A5 JP 2004532865A5
- Authority
- JP
- Japan
- Prior art keywords
- acid
- pharmaceutical composition
- tartrate
- magnesium
- carnitine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002253 acid Substances 0.000 claims 9
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims 4
- RDHQFKQIGNGIED-MRVPVSSYSA-N O-acetyl-L-carnitine Chemical compound CC(=O)O[C@H](CC([O-])=O)C[N+](C)(C)C RDHQFKQIGNGIED-MRVPVSSYSA-N 0.000 claims 3
- -1 mucate Substances 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims 2
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims 2
- 230000000202 analgesic effect Effects 0.000 claims 2
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 claims 2
- 229940095064 tartrate Drugs 0.000 claims 2
- NDVRKEKNSBMTAX-BTVCFUMJSA-N (2r,3s,4r,5r)-2,3,4,5,6-pentahydroxyhexanal;phosphoric acid Chemical compound OP(O)(O)=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O NDVRKEKNSBMTAX-BTVCFUMJSA-N 0.000 claims 1
- QWJSAWXRUVVRLH-LREBCSMRSA-M 2-hydroxyethyl(trimethyl)azanium;(2r,3r)-2,3,4-trihydroxy-4-oxobutanoate Chemical compound C[N+](C)(C)CCO.OC(=O)[C@H](O)[C@@H](O)C([O-])=O QWJSAWXRUVVRLH-LREBCSMRSA-M 0.000 claims 1
- CNPURSDMOWDNOQ-UHFFFAOYSA-N 4-methoxy-7h-pyrrolo[2,3-d]pyrimidin-2-amine Chemical compound COC1=NC(N)=NC2=C1C=CN2 CNPURSDMOWDNOQ-UHFFFAOYSA-N 0.000 claims 1
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 claims 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 1
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 claims 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims 1
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 claims 1
- 229910019142 PO4 Inorganic materials 0.000 claims 1
- 208000002193 Pain Diseases 0.000 claims 1
- 208000004550 Postoperative Pain Diseases 0.000 claims 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims 1
- 229940009098 aspartate Drugs 0.000 claims 1
- 150000001805 chlorine compounds Chemical group 0.000 claims 1
- CCIVGXIOQKPBKL-UHFFFAOYSA-M ethanesulfonate Chemical compound CCS([O-])(=O)=O CCIVGXIOQKPBKL-UHFFFAOYSA-M 0.000 claims 1
- 229910052749 magnesium Inorganic materials 0.000 claims 1
- 239000011777 magnesium Substances 0.000 claims 1
- 229960005336 magnesium citrate Drugs 0.000 claims 1
- 235000002538 magnesium citrate Nutrition 0.000 claims 1
- 239000004337 magnesium citrate Substances 0.000 claims 1
- 229940091250 magnesium supplement Drugs 0.000 claims 1
- 229940095060 magnesium tartrate Drugs 0.000 claims 1
- MUZDLCBWNVUYIR-ZVGUSBNCSA-L magnesium;(2r,3r)-2,3-dihydroxybutanedioate Chemical compound [Mg+2].[O-]C(=O)[C@H](O)[C@@H](O)C([O-])=O MUZDLCBWNVUYIR-ZVGUSBNCSA-L 0.000 claims 1
- QUIOHQITLKCGNW-TYYBGVCCSA-L magnesium;(e)-but-2-enedioate Chemical compound [Mg+2].[O-]C(=O)\C=C\C([O-])=O QUIOHQITLKCGNW-TYYBGVCCSA-L 0.000 claims 1
- PXQPEWDEAKTCGB-UHFFFAOYSA-N orotic acid Chemical compound OC(=O)C1=CC(=O)NC(=O)N1 PXQPEWDEAKTCGB-UHFFFAOYSA-N 0.000 claims 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 1
- 239000010452 phosphate Substances 0.000 claims 1
- 238000009117 preventive therapy Methods 0.000 claims 1
- 230000000069 prophylactic effect Effects 0.000 claims 1
- 238000011321 prophylaxis Methods 0.000 claims 1
- 229940066528 trichloroacetate Drugs 0.000 claims 1
- YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 claims 1
- PLSARIKBYIPYPF-UHFFFAOYSA-H trimagnesium dicitrate Chemical compound [Mg+2].[Mg+2].[Mg+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O PLSARIKBYIPYPF-UHFFFAOYSA-H 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2001RM000293A ITRM20010293A1 (it) | 2001-05-29 | 2001-05-29 | Uso della acetil-l-carnetina per la preparazione di un medicamento per la prevenzione del dolore. |
| PCT/IT2002/000336 WO2002096409A1 (en) | 2001-05-29 | 2002-05-24 | Use of acetyl l-carnitine for the preparation of a medication for the preventive therapy for pain |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004532865A JP2004532865A (ja) | 2004-10-28 |
| JP2004532865A5 true JP2004532865A5 (enExample) | 2006-01-05 |
| JP4287660B2 JP4287660B2 (ja) | 2009-07-01 |
Family
ID=11455557
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002592919A Expired - Fee Related JP4287660B2 (ja) | 2001-05-29 | 2002-05-24 | 疼痛の予防療法用薬物の調製のためのアセチルｌ−カルニチンの使用 |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US20040152781A1 (enExample) |
| EP (1) | EP1399141B1 (enExample) |
| JP (1) | JP4287660B2 (enExample) |
| KR (1) | KR100873748B1 (enExample) |
| AT (1) | ATE374021T1 (enExample) |
| CA (1) | CA2448242C (enExample) |
| CY (1) | CY1107037T1 (enExample) |
| CZ (1) | CZ20033220A3 (enExample) |
| DE (1) | DE60222662T2 (enExample) |
| DK (1) | DK1399141T3 (enExample) |
| ES (1) | ES2290292T3 (enExample) |
| HU (1) | HUP0401294A3 (enExample) |
| IT (1) | ITRM20010293A1 (enExample) |
| MX (1) | MXPA03010919A (enExample) |
| PL (1) | PL367616A1 (enExample) |
| PT (1) | PT1399141E (enExample) |
| SK (1) | SK287559B6 (enExample) |
| WO (1) | WO2002096409A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITRM20040606A1 (it) * | 2004-12-13 | 2005-03-13 | Sigma Tau Ind Farmaceuti | Uso della acetil l-carnitina per il trattamento della sindrome fibromialgica. |
| JP5685362B2 (ja) * | 2005-04-26 | 2015-03-18 | シグマ−タウ・インドゥストリエ・ファルマチェウチケ・リウニテ・ソシエタ・ペル・アチオニＳｉｇｍａ−Ｔａｕ Ｉｎｄｕｓｔｒｉｅ Ｆａｒｍａｃｅｕｔｉｃｈｅ Ｒｉｕｎｉｔｅ Ｓｏｃｉｅｔａ Ｐｅｒ Ａｚｉｏｎｉ | 有痛性末梢糖尿病性神経障害の予防のためのアセチルｌ−カルニチン |
| IT202200022437A1 (it) | 2022-11-02 | 2024-05-02 | Chiesi Italia S P A | Composizione farmaceutica comprendente l-acetilcarnitina e beta-cariofillene |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0150688B1 (en) * | 1983-12-28 | 1987-04-22 | Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. | Salts of l-carnitine and alkanoyl l-carnitines and process for preparing same |
| IT1196564B (it) * | 1986-08-04 | 1988-11-16 | Sigma Tau Ind Farmaceuti | Impiego di acetil l-carnitina nel trattamento terapeutico delle neuropatie periferiche |
| IT1277147B1 (it) * | 1995-01-20 | 1997-11-04 | Sigma Tau Ind Farmaceuti | Uso della carnitina e i suoi derivati per ridurre gli effetti tossici della ciclosporina-a e di altri farmaci immunosoppressivi. |
-
2001
- 2001-05-29 IT IT2001RM000293A patent/ITRM20010293A1/it unknown
-
2002
- 2002-05-24 HU HU0401294A patent/HUP0401294A3/hu unknown
- 2002-05-24 US US10/478,379 patent/US20040152781A1/en not_active Abandoned
- 2002-05-24 MX MXPA03010919A patent/MXPA03010919A/es active IP Right Grant
- 2002-05-24 KR KR1020037015574A patent/KR100873748B1/ko not_active Expired - Fee Related
- 2002-05-24 EP EP02728055A patent/EP1399141B1/en not_active Expired - Lifetime
- 2002-05-24 AT AT02728055T patent/ATE374021T1/de not_active IP Right Cessation
- 2002-05-24 PT PT02728055T patent/PT1399141E/pt unknown
- 2002-05-24 JP JP2002592919A patent/JP4287660B2/ja not_active Expired - Fee Related
- 2002-05-24 CA CA2448242A patent/CA2448242C/en not_active Expired - Fee Related
- 2002-05-24 DE DE60222662T patent/DE60222662T2/de not_active Expired - Lifetime
- 2002-05-24 DK DK02728055T patent/DK1399141T3/da active
- 2002-05-24 CZ CZ20033220A patent/CZ20033220A3/cs unknown
- 2002-05-24 SK SK1584-2003A patent/SK287559B6/sk not_active IP Right Cessation
- 2002-05-24 ES ES02728055T patent/ES2290292T3/es not_active Expired - Lifetime
- 2002-05-24 WO PCT/IT2002/000336 patent/WO2002096409A1/en not_active Ceased
- 2002-05-24 PL PL02367616A patent/PL367616A1/xx not_active IP Right Cessation
-
2007
- 2007-11-28 CY CY20071101520T patent/CY1107037T1/el unknown
-
2008
- 2008-09-26 US US12/232,945 patent/US20090062388A1/en not_active Abandoned
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