JP2002542298A - 低分子量トロンビン阻害物質およびそのプロドラッグを含む医薬製剤 - Google Patents
低分子量トロンビン阻害物質およびそのプロドラッグを含む医薬製剤Info
- Publication number
- JP2002542298A JP2002542298A JP2000613460A JP2000613460A JP2002542298A JP 2002542298 A JP2002542298 A JP 2002542298A JP 2000613460 A JP2000613460 A JP 2000613460A JP 2000613460 A JP2000613460 A JP 2000613460A JP 2002542298 A JP2002542298 A JP 2002542298A
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutically acceptable
- prodrug
- molecular weight
- low molecular
- thrombin inhibitor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9901442A SE523811C2 (sv) | 1999-04-21 | 1999-04-21 | Beredning innehållande en trombininhibitor med låg molekylvikt tillsammans med en prodrog av densamma |
| SE9901442-5 | 1999-04-21 | ||
| SE9904419-0 | 1999-12-03 | ||
| SE9904419A SE9904419D0 (sv) | 1999-12-03 | 1999-12-03 | New use |
| PCT/SE2000/000756 WO2000064470A1 (en) | 1999-04-21 | 2000-04-19 | A pharmaceutical formulation comprising a low molecular weight thrombin inhibitor and its prodrug |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002542298A true JP2002542298A (ja) | 2002-12-10 |
| JP2002542298A5 JP2002542298A5 (https=) | 2007-06-14 |
Family
ID=26663557
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000613460A Pending JP2002542298A (ja) | 1999-04-21 | 2000-04-19 | 低分子量トロンビン阻害物質およびそのプロドラッグを含む医薬製剤 |
Country Status (29)
| Country | Link |
|---|---|
| US (3) | US6962905B1 (https=) |
| EP (2) | EP1886691A3 (https=) |
| JP (1) | JP2002542298A (https=) |
| KR (1) | KR20010110788A (https=) |
| CN (1) | CN100377742C (https=) |
| AR (1) | AR023510A1 (https=) |
| AT (1) | ATE383868T1 (https=) |
| AU (1) | AU754405B2 (https=) |
| BR (1) | BR0009847A (https=) |
| CA (1) | CA2371008A1 (https=) |
| CZ (1) | CZ20013757A3 (https=) |
| DE (1) | DE60037816T2 (https=) |
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| EE (1) | EE200100543A (https=) |
| ES (1) | ES2298141T3 (https=) |
| HK (1) | HK1045465B (https=) |
| HU (1) | HUP0200955A3 (https=) |
| IL (1) | IL145840A0 (https=) |
| IS (1) | IS6111A (https=) |
| MY (1) | MY128061A (https=) |
| NO (1) | NO20015107D0 (https=) |
| NZ (1) | NZ514827A (https=) |
| PL (1) | PL201793B1 (https=) |
| PT (1) | PT1200118E (https=) |
| RU (1) | RU2252783C2 (https=) |
| SA (1) | SA00210092B1 (https=) |
| SK (1) | SK14962001A3 (https=) |
| TR (1) | TR200103017T2 (https=) |
| WO (1) | WO2000064470A1 (https=) |
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| JP2006520813A (ja) * | 2003-03-22 | 2006-09-14 | アストラゼネカ アクチボラグ | 低分子量トロンビン阻害剤のコレステロール低下療法における使用 |
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| SE9900070D0 (sv) | 1999-01-13 | 1999-01-13 | Astra Ab | New use |
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| US20020116222A1 (en) * | 2000-10-22 | 2002-08-22 | Standing Stone, Inc. | Method and system for administering anticoagulation therapy |
| US6462021B1 (en) * | 2000-11-06 | 2002-10-08 | Astrazeneca Ab | Use of low molecular weight thrombin inhibitor |
| DE10064797A1 (de) * | 2000-12-22 | 2002-06-27 | Knoll Ag | Orale und parenterale pharmazeutische Formulierung, umfassend eine niedermolekulare Thrombininhibitor-Pro-Pharmakon |
| SE0101762D0 (sv) * | 2001-05-18 | 2001-05-18 | Astrazeneca Ab | New use |
| SE0101932D0 (sv) * | 2001-05-31 | 2001-05-31 | Astrazeneca Ab | Pharmaceutical combinations |
| SE0103590D0 (sv) | 2001-10-26 | 2001-10-26 | Astrazeneca Ab | New Combination |
| US7838560B2 (en) | 2002-03-11 | 2010-11-23 | The Medicines Company (Leipzig) Gmbh | Urokinase inhibitors, production and use thereof |
| SE0203349D0 (sv) * | 2002-11-12 | 2002-11-12 | Astrazeneca Ab | New use |
| DE10301300B4 (de) | 2003-01-15 | 2009-07-16 | Curacyte Chemistry Gmbh | Verwendung von acylierten 4-Amidino- und 4-Guanidinobenzylaminen zur Inhibierung von Plasmakallikrein |
| DE10342108A1 (de) * | 2003-09-11 | 2005-04-14 | Curacyte Chemistry Gmbh | Basisch-substituierte Benzylaminanaloga als Inhibitoren des Gerinnungsfaktors Xa, ihre Herstellung und Verwendung |
| DE102005044319A1 (de) | 2005-09-16 | 2007-03-22 | Curacyte Chemistry Gmbh | 2-(Aminomethyl)-5-Chlor-Benzylamid-Derivate und ihre Verwendung als Hemmstoffe des Gerinnungsfaktors Xa |
| DE102006050672A1 (de) | 2006-10-24 | 2008-04-30 | Curacyte Discovery Gmbh | Hemmstoffe des Plasmins und des Plasmakallikreins |
| JP6155187B2 (ja) | 2010-03-30 | 2017-06-28 | ヴァーセオン コーポレイション | トロンビンの阻害剤としての多置換芳香族化合物 |
| CN110179795A (zh) | 2013-03-15 | 2019-08-30 | 维颂公司 | 作为丝氨酸蛋白酶抑制剂的多取代芳族化合物的制药用途 |
| HK1214252A1 (zh) | 2013-03-15 | 2016-07-22 | Verseon Corporation | 作為凝血酶抑制劑的鹵代吡唑 |
| US10189810B2 (en) | 2014-09-17 | 2019-01-29 | Verseon Corporation | Pyrazolyl-substituted pyridone compounds as serine protease inhibitors |
| CN107405333A (zh) | 2015-02-27 | 2017-11-28 | 维颂公司 | 作为丝氨酸蛋白酶抑制剂的被取代的吡唑化合物 |
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- 2000-04-14 AR ARP000101756A patent/AR023510A1/es not_active Application Discontinuation
- 2000-04-19 HU HU0200955A patent/HUP0200955A3/hu unknown
- 2000-04-19 KR KR1020017013403A patent/KR20010110788A/ko not_active Abandoned
- 2000-04-19 ES ES00928047T patent/ES2298141T3/es not_active Expired - Lifetime
- 2000-04-19 BR BR0009847-7A patent/BR0009847A/pt not_active Application Discontinuation
- 2000-04-19 DK DK00928047T patent/DK1200118T3/da active
- 2000-04-19 AT AT00928047T patent/ATE383868T1/de not_active IP Right Cessation
- 2000-04-19 US US09/582,863 patent/US6962905B1/en not_active Expired - Fee Related
- 2000-04-19 EE EEP200100543A patent/EE200100543A/xx unknown
- 2000-04-19 MY MYPI20001656A patent/MY128061A/en unknown
- 2000-04-19 PL PL351917A patent/PL201793B1/pl unknown
- 2000-04-19 JP JP2000613460A patent/JP2002542298A/ja active Pending
- 2000-04-19 CN CNB008091447A patent/CN100377742C/zh not_active Expired - Fee Related
- 2000-04-19 WO PCT/SE2000/000756 patent/WO2000064470A1/en not_active Ceased
- 2000-04-19 AU AU46336/00A patent/AU754405B2/en not_active Ceased
- 2000-04-19 IL IL14584000A patent/IL145840A0/xx unknown
- 2000-04-19 CA CA002371008A patent/CA2371008A1/en not_active Abandoned
- 2000-04-19 DE DE60037816T patent/DE60037816T2/de not_active Expired - Fee Related
- 2000-04-19 RU RU2001128157/15A patent/RU2252783C2/ru active
- 2000-04-19 EP EP07120002A patent/EP1886691A3/en not_active Withdrawn
- 2000-04-19 CZ CZ20013757A patent/CZ20013757A3/cs unknown
- 2000-04-19 SK SK1496-2001A patent/SK14962001A3/sk unknown
- 2000-04-19 TR TR2001/03017T patent/TR200103017T2/xx unknown
- 2000-04-19 PT PT00928047T patent/PT1200118E/pt unknown
- 2000-04-19 NZ NZ514827A patent/NZ514827A/en unknown
- 2000-04-19 HK HK02107166.1A patent/HK1045465B/en not_active IP Right Cessation
- 2000-04-19 EP EP00928047A patent/EP1200118B1/en not_active Expired - Lifetime
- 2000-05-15 SA SA00210092A patent/SA00210092B1/ar unknown
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2001
- 2001-10-19 NO NO20015107A patent/NO20015107D0/no not_active Application Discontinuation
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2005
- 2005-08-18 US US11/206,006 patent/US20060009397A1/en not_active Abandoned
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