CN100377742C - 包含低分子量凝血酶抑制剂及其药物前体的药用制剂 - Google Patents

包含低分子量凝血酶抑制剂及其药物前体的药用制剂 Download PDF

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Publication number
CN100377742C
CN100377742C CNB008091447A CN00809144A CN100377742C CN 100377742 C CN100377742 C CN 100377742C CN B008091447 A CNB008091447 A CN B008091447A CN 00809144 A CN00809144 A CN 00809144A CN 100377742 C CN100377742 C CN 100377742C
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CN
China
Prior art keywords
component
prodrug
kit
pharmaceutically acceptable
thrombin inhibitor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB008091447A
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English (en)
Chinese (zh)
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CN1356908A (zh
Inventor
D·古斯塔夫松
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AstraZeneca AB
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AstraZeneca AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE9901442A external-priority patent/SE523811C2/sv
Priority claimed from SE9904419A external-priority patent/SE9904419D0/xx
Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Publication of CN1356908A publication Critical patent/CN1356908A/zh
Application granted granted Critical
Publication of CN100377742C publication Critical patent/CN100377742C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
CNB008091447A 1999-04-21 2000-04-19 包含低分子量凝血酶抑制剂及其药物前体的药用制剂 Expired - Fee Related CN100377742C (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
SE99014425 1999-04-21
SE9901442A SE523811C2 (sv) 1999-04-21 1999-04-21 Beredning innehållande en trombininhibitor med låg molekylvikt tillsammans med en prodrog av densamma
SE9904419A SE9904419D0 (sv) 1999-12-03 1999-12-03 New use
SE99044190 1999-12-03
PCT/SE2000/000756 WO2000064470A1 (en) 1999-04-21 2000-04-19 A pharmaceutical formulation comprising a low molecular weight thrombin inhibitor and its prodrug

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CNA2008100039275A Division CN101219204A (zh) 1999-04-21 2000-04-19 包含低分子量凝血酶抑制剂及其药物前体的药用制剂

Publications (2)

Publication Number Publication Date
CN1356908A CN1356908A (zh) 2002-07-03
CN100377742C true CN100377742C (zh) 2008-04-02

Family

ID=26663557

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB008091447A Expired - Fee Related CN100377742C (zh) 1999-04-21 2000-04-19 包含低分子量凝血酶抑制剂及其药物前体的药用制剂

Country Status (29)

Country Link
US (3) US6962905B1 (https=)
EP (2) EP1200118B1 (https=)
JP (1) JP2002542298A (https=)
KR (1) KR20010110788A (https=)
CN (1) CN100377742C (https=)
AR (1) AR023510A1 (https=)
AT (1) ATE383868T1 (https=)
AU (1) AU754405B2 (https=)
BR (1) BR0009847A (https=)
CA (1) CA2371008A1 (https=)
CZ (1) CZ20013757A3 (https=)
DE (1) DE60037816T2 (https=)
DK (1) DK1200118T3 (https=)
EE (1) EE200100543A (https=)
ES (1) ES2298141T3 (https=)
HK (1) HK1045465B (https=)
HU (1) HUP0200955A3 (https=)
IL (1) IL145840A0 (https=)
IS (1) IS6111A (https=)
MY (1) MY128061A (https=)
NO (1) NO20015107D0 (https=)
NZ (1) NZ514827A (https=)
PL (1) PL201793B1 (https=)
PT (1) PT1200118E (https=)
RU (1) RU2252783C2 (https=)
SA (1) SA00210092B1 (https=)
SK (1) SK14962001A3 (https=)
TR (1) TR200103017T2 (https=)
WO (1) WO2000064470A1 (https=)

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SE9900070D0 (sv) 1999-01-13 1999-01-13 Astra Ab New use
AR023510A1 (es) * 1999-04-21 2002-09-04 Astrazeneca Ab Un equipo de partes, formulacion farmaceutica y uso de un inhibidor de trombina.
US20020116222A1 (en) * 2000-10-22 2002-08-22 Standing Stone, Inc. Method and system for administering anticoagulation therapy
US6462021B1 (en) * 2000-11-06 2002-10-08 Astrazeneca Ab Use of low molecular weight thrombin inhibitor
DE10064797A1 (de) * 2000-12-22 2002-06-27 Knoll Ag Orale und parenterale pharmazeutische Formulierung, umfassend eine niedermolekulare Thrombininhibitor-Pro-Pharmakon
SE0101762D0 (sv) * 2001-05-18 2001-05-18 Astrazeneca Ab New use
SE0101932D0 (sv) * 2001-05-31 2001-05-31 Astrazeneca Ab Pharmaceutical combinations
SE0103590D0 (sv) * 2001-10-26 2001-10-26 Astrazeneca Ab New Combination
AU2003219039A1 (en) 2002-03-11 2003-09-22 Curacyte Ag Urokinase inhibitors, production and use thereof
SE0203349D0 (sv) * 2002-11-12 2002-11-12 Astrazeneca Ab New use
DE10301300B4 (de) 2003-01-15 2009-07-16 Curacyte Chemistry Gmbh Verwendung von acylierten 4-Amidino- und 4-Guanidinobenzylaminen zur Inhibierung von Plasmakallikrein
GB0306615D0 (en) * 2003-03-22 2003-04-30 Astrazeneca Ab New use
DE10342108A1 (de) * 2003-09-11 2005-04-14 Curacyte Chemistry Gmbh Basisch-substituierte Benzylaminanaloga als Inhibitoren des Gerinnungsfaktors Xa, ihre Herstellung und Verwendung
DE102005044319A1 (de) 2005-09-16 2007-03-22 Curacyte Chemistry Gmbh 2-(Aminomethyl)-5-Chlor-Benzylamid-Derivate und ihre Verwendung als Hemmstoffe des Gerinnungsfaktors Xa
DE102006050672A1 (de) 2006-10-24 2008-04-30 Curacyte Discovery Gmbh Hemmstoffe des Plasmins und des Plasmakallikreins
CN102918034B (zh) * 2010-03-30 2015-06-03 维颂公司 多取代芳族化合物作为凝血酶的抑制剂
ES2791749T3 (es) 2013-03-15 2020-11-05 Verseon Corp Halogenopirazoles como inhibidores de la trombina
LT2968297T (lt) 2013-03-15 2019-01-10 Verseon Corporation Multipakeistieji aromatiniai junginiai kaip serino proteazės inhibitoriai
CN106687445A (zh) 2014-09-17 2017-05-17 维颂公司 作为丝氨酸蛋白酶抑制剂的吡唑基取代的吡啶酮化合物
RU2017131562A (ru) 2015-02-27 2019-03-27 Версеон Корпорейшн Замещенные пиразольные соединения как ингибиторы сериновых протеаз

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Publication number Priority date Publication date Assignee Title
CN1127509A (zh) * 1993-06-03 1996-07-24 阿斯特拉公司 新的肽衍生物
CN1168638A (zh) * 1994-11-28 1997-12-24 普罗克特和甘保尔公司 上层涂有洗剂的尿布
CN1209139A (zh) * 1995-12-21 1999-02-24 阿斯特拉公司 凝血酶抑制剂的药物前体

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CN1168638A (zh) * 1994-11-28 1997-12-24 普罗克特和甘保尔公司 上层涂有洗剂的尿布
CN1209139A (zh) * 1995-12-21 1999-02-24 阿斯特拉公司 凝血酶抑制剂的药物前体

Also Published As

Publication number Publication date
KR20010110788A (ko) 2001-12-13
EE200100543A (et) 2003-02-17
DE60037816T2 (de) 2009-01-08
IS6111A (is) 2001-10-19
ATE383868T1 (de) 2008-02-15
SK14962001A3 (sk) 2002-06-04
HUP0200955A3 (en) 2006-07-28
BR0009847A (pt) 2002-01-08
HK1045465A1 (en) 2002-11-29
TR200103017T2 (tr) 2002-05-21
RU2252783C2 (ru) 2005-05-27
PL201793B1 (pl) 2009-05-29
CZ20013757A3 (cs) 2002-05-15
US20080113960A1 (en) 2008-05-15
EP1886691A2 (en) 2008-02-13
MY128061A (en) 2007-01-31
JP2002542298A (ja) 2002-12-10
EP1200118B1 (en) 2008-01-16
DK1200118T3 (da) 2008-04-21
AU754405B2 (en) 2002-11-14
WO2000064470A1 (en) 2000-11-02
US6962905B1 (en) 2005-11-08
NO20015107L (no) 2001-10-19
HUP0200955A2 (en) 2002-09-28
SA00210092B1 (ar) 2006-11-11
EP1200118A1 (en) 2002-05-02
HK1045465B (en) 2008-08-01
IL145840A0 (en) 2002-07-25
NZ514827A (en) 2005-01-28
PL351917A1 (en) 2003-06-30
DE60037816D1 (de) 2008-03-06
CA2371008A1 (en) 2000-11-02
AR023510A1 (es) 2002-09-04
US20060009397A1 (en) 2006-01-12
CN1356908A (zh) 2002-07-03
ES2298141T3 (es) 2008-05-16
EP1886691A3 (en) 2008-03-05
NO20015107D0 (no) 2001-10-19
PT1200118E (pt) 2008-03-18
AU4633600A (en) 2000-11-10

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