JP2002536300A5 - - Google Patents
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- Publication number
- JP2002536300A5 JP2002536300A5 JP2000596019A JP2000596019A JP2002536300A5 JP 2002536300 A5 JP2002536300 A5 JP 2002536300A5 JP 2000596019 A JP2000596019 A JP 2000596019A JP 2000596019 A JP2000596019 A JP 2000596019A JP 2002536300 A5 JP2002536300 A5 JP 2002536300A5
- Authority
- JP
- Japan
- Prior art keywords
- composition object
- compound
- alkyl
- inflammatory response
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 description 31
- -1 hydroxy, amino Chemical group 0.000 description 19
- 230000028709 inflammatory response Effects 0.000 description 13
- 150000001875 compounds Chemical class 0.000 description 7
- 125000000217 alkyl group Chemical group 0.000 description 5
- 125000000753 cycloalkyl group Chemical group 0.000 description 4
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 125000006260 ethylaminocarbonyl group Chemical group [H]N(C(*)=O)C([H])([H])C([H])([H])[H] 0.000 description 4
- 150000003839 salts Chemical class 0.000 description 4
- 125000006619 (C1-C6) dialkylamino group Chemical group 0.000 description 3
- 229940099471 Phosphodiesterase inhibitor Drugs 0.000 description 3
- 229910052736 halogen Inorganic materials 0.000 description 3
- 150000002367 halogens Chemical class 0.000 description 3
- 239000002571 phosphodiesterase inhibitor Substances 0.000 description 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 3
- KXKVLQRXCPHEJC-UHFFFAOYSA-N acetic acid trimethyl ester Natural products COC(C)=O KXKVLQRXCPHEJC-UHFFFAOYSA-N 0.000 description 2
- 125000004453 alkoxycarbonyl group Chemical group 0.000 description 2
- NZNMSOFKMUBTKW-UHFFFAOYSA-M cyclohexanecarboxylate Chemical compound [O-]C(=O)C1CCCCC1 NZNMSOFKMUBTKW-UHFFFAOYSA-M 0.000 description 2
- NZNMSOFKMUBTKW-UHFFFAOYSA-N cyclohexanecarboxylic acid Chemical compound OC(=O)C1CCCCC1 NZNMSOFKMUBTKW-UHFFFAOYSA-N 0.000 description 2
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 description 2
- 230000002757 inflammatory effect Effects 0.000 description 2
- 208000028867 ischemia Diseases 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 2
- HJORMJIFDVBMOB-UHFFFAOYSA-N rolipram Chemical group COC1=CC=C(C2CC(=O)NC2)C=C1OC1CCCC1 HJORMJIFDVBMOB-UHFFFAOYSA-N 0.000 description 2
- 229950005741 rolipram Drugs 0.000 description 2
- 238000002054 transplantation Methods 0.000 description 2
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 description 1
- 102000009346 Adenosine receptors Human genes 0.000 description 1
- 108050000203 Adenosine receptors Proteins 0.000 description 1
- 201000001320 Atherosclerosis Diseases 0.000 description 1
- 208000023275 Autoimmune disease Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 206010063837 Reperfusion injury Diseases 0.000 description 1
- 208000006011 Stroke Diseases 0.000 description 1
- 208000030886 Traumatic Brain injury Diseases 0.000 description 1
- 230000008484 agonism Effects 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 238000002399 angioplasty Methods 0.000 description 1
- 125000005418 aryl aryl group Chemical group 0.000 description 1
- VZFUCHSFHOYXIS-UHFFFAOYSA-N cycloheptane carboxylic acid Natural products OC(=O)C1CCCCCC1 VZFUCHSFHOYXIS-UHFFFAOYSA-N 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- FPIQZBQZKBKLEI-UHFFFAOYSA-N ethyl 1-[[2-chloroethyl(nitroso)carbamoyl]amino]cyclohexane-1-carboxylate Chemical compound ClCCN(N=O)C(=O)NC1(C(=O)OCC)CCCCC1 FPIQZBQZKBKLEI-UHFFFAOYSA-N 0.000 description 1
- 210000002216 heart Anatomy 0.000 description 1
- 150000002431 hydrogen Chemical class 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 238000002650 immunosuppressive therapy Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 150000002978 peroxides Chemical class 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- 208000020431 spinal cord injury Diseases 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000009529 traumatic brain injury Effects 0.000 description 1
Applications Claiming Priority (13)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11802999P | 1999-02-01 | 1999-02-01 | |
| US60/118,029 | 1999-02-01 | ||
| US12431699P | 1999-03-12 | 1999-03-12 | |
| US60/124,316 | 1999-03-12 | ||
| US13337499P | 1999-05-10 | 1999-05-10 | |
| US60/133,374 | 1999-05-10 | ||
| US13557399P | 1999-05-24 | 1999-05-24 | |
| US60/135,573 | 1999-05-24 | ||
| US09/333,387 | 1999-06-15 | ||
| US09/333,387 US6232297B1 (en) | 1999-02-01 | 1999-06-15 | Methods and compositions for treating inflammatory response |
| US15141299P | 1999-08-30 | 1999-08-30 | |
| US60/151,412 | 1999-08-30 | ||
| PCT/US2000/002324 WO2000044763A2 (en) | 1999-02-01 | 2000-01-31 | Compositions for treating inflammatory response |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002536300A JP2002536300A (ja) | 2002-10-29 |
| JP2002536300A5 true JP2002536300A5 (https=) | 2010-12-24 |
| JP4837831B2 JP4837831B2 (ja) | 2011-12-14 |
Family
ID=27557920
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000596019A Expired - Fee Related JP4837831B2 (ja) | 1999-02-01 | 2000-01-31 | 炎症反応を治療するための組成物 |
Country Status (25)
| Country | Link |
|---|---|
| EP (1) | EP1150991B1 (https=) |
| JP (1) | JP4837831B2 (https=) |
| KR (1) | KR100668006B1 (https=) |
| CN (1) | CN1191266C (https=) |
| AR (1) | AR029332A1 (https=) |
| AT (1) | ATE263777T1 (https=) |
| AU (2) | AU778870B2 (https=) |
| BR (1) | BR0007864A (https=) |
| CA (1) | CA2361614C (https=) |
| CZ (1) | CZ296404B6 (https=) |
| DE (1) | DE60009665T2 (https=) |
| DK (1) | DK1150991T3 (https=) |
| EE (1) | EE05185B1 (https=) |
| ES (1) | ES2215609T3 (https=) |
| HU (1) | HU228937B1 (https=) |
| IL (2) | IL144188A0 (https=) |
| MX (1) | MXPA01007850A (https=) |
| MY (1) | MY129445A (https=) |
| NO (1) | NO321216B1 (https=) |
| NZ (1) | NZ513096A (https=) |
| PL (1) | PL199953B1 (https=) |
| PT (1) | PT1150991E (https=) |
| SK (1) | SK284877B6 (https=) |
| UA (1) | UA72912C2 (https=) |
| WO (1) | WO2000044763A2 (https=) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6514949B1 (en) | 1994-07-11 | 2003-02-04 | University Of Virginia Patent Foundation | Method compositions for treating the inflammatory response |
| US6448235B1 (en) | 1994-07-11 | 2002-09-10 | University Of Virginia Patent Foundation | Method for treating restenosis with A2A adenosine receptor agonists |
| US6232297B1 (en) | 1999-02-01 | 2001-05-15 | University Of Virginia Patent Foundation | Methods and compositions for treating inflammatory response |
| US7427606B2 (en) | 1999-02-01 | 2008-09-23 | University Of Virginia Patent Foundation | Method to reduce inflammatory response in transplanted tissue |
| US7378400B2 (en) | 1999-02-01 | 2008-05-27 | University Of Virginia Patent Foundation | Method to reduce an inflammatory response from arthritis |
| US6322771B1 (en) * | 1999-06-18 | 2001-11-27 | University Of Virginia Patent Foundation | Induction of pharmacological stress with adenosine receptor agonists |
| IL133680A0 (en) * | 1999-09-10 | 2001-04-30 | Can Fite Technologies Ltd | Pharmaceutical compositions comprising an adenosine receptor agonist or antagonist |
| EP1434782A2 (en) | 2001-10-01 | 2004-07-07 | University of Virginia Patent Foundation | 2-propynyl adenosine analogs having a2a agonist activity and compositions thereof |
| US20050033044A1 (en) | 2003-05-19 | 2005-02-10 | Bristol-Myers Squibb Pharma Company | Methods for preparing 2-alkynyladenosine derivatives |
| CA2563123A1 (en) * | 2004-04-02 | 2005-10-20 | Adenosine Therapeutics, Llc | Selective antagonists of a2a adenosine receptors |
| WO2005107463A1 (en) * | 2004-05-03 | 2005-11-17 | University Of Virginia Patent Foundation | Agonists of a2a adenosine receptors for treatment of diabetic nephropathy |
| US7442687B2 (en) | 2004-08-02 | 2008-10-28 | The University Of Virginia Patent Foundation | 2-polycyclic propynyl adenosine analogs having A2A agonist activity |
| AU2005267706B2 (en) * | 2004-08-02 | 2011-12-08 | University Of Virginia Patent Foundation | 2-propynyl adenosine analogs with modified 5'-ribose groups having A2A agonist activity |
| US7576069B2 (en) | 2004-08-02 | 2009-08-18 | University Of Virginia Patent Foundation | 2-polycyclic propynyl adenosine analogs having A2A agonist activity |
| WO2007120972A2 (en) | 2006-02-10 | 2007-10-25 | University Of Virginia Patent Foundation | Method to treat sickle cell disease |
| WO2007107598A1 (en) | 2006-03-21 | 2007-09-27 | Heinrich-Heine-Universität Düsseldorf | Phosphorylated a2a receptor agonists |
| US8188063B2 (en) | 2006-06-19 | 2012-05-29 | University Of Virginia Patent Foundation | Use of adenosine A2A modulators to treat spinal cord injury |
| AU2007263728A1 (en) * | 2006-06-27 | 2008-01-03 | Biovitrum Ab (Publ) | Adenosine derivatives for the treatment of pain |
| US8058259B2 (en) | 2007-12-20 | 2011-11-15 | University Of Virginia Patent Foundation | Substituted 4-{3-[6-amino-9-(3,4-dihydroxy-tetrahydro-furan-2-yl)-9H-purin-2-yl]-prop-2-ynyl}-piperidine-1-carboxylic acid esters as A2AR agonists |
| CN102119023B (zh) | 2008-07-03 | 2014-04-09 | 弗吉尼亚大学专利基金会 | 阿帕地松单位剂量 |
| EA201270102A1 (ru) | 2009-06-30 | 2012-08-30 | Форест Лэборетериз Холдингз Лимитед | Соединения алкокси-карбонил-амино-алкинил-аденозина и их производные в качестве агонистов ar |
| FR2960876B1 (fr) | 2010-06-03 | 2012-07-27 | Sanofi Aventis | Derives de 3,4-dihydropyrrolo[1,2-a]pyrazine-2,8(1h)-dicarboxamide leur preparation et leur application en therapeutique. |
| JP2022538410A (ja) * | 2019-06-21 | 2022-09-02 | アカデミー オブ ミリタリー メディカル サイエンシズ | Ａ２ａアデノシン受容体拮抗作用を有する小分子化合物 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3537228A1 (de) * | 1985-10-19 | 1987-04-23 | Huels Chemische Werke Ag | Verfahren zur herstellung von cyclohexylverbindungen |
| JPS6299330A (ja) * | 1985-10-25 | 1987-05-08 | Yamasa Shoyu Co Ltd | 抗高血圧剤 |
| US5270304A (en) * | 1988-11-15 | 1993-12-14 | Yamasa Shoyu Kabushiki Kaisha | Therapeutic 2-alkynyl adenosine agent for ischemic diseases of the heart or brain |
| KR920700218A (ko) * | 1989-06-20 | 1992-02-19 | 원본미기재 | 2-알키닐 아데노신의 합성중간체, 그 합성 중간체의 제조법, 그 합성중간체를 이용한 2-알키닐 아데노신의 제조법 및 안정한 2-알키닐 아데노신 유도체 |
| WO1991009864A1 (fr) * | 1990-01-04 | 1991-07-11 | Yamasa Shoyu Kabushiki Kaisha | Medicament pour le traitement d'affections ischemiques du c×ur ou du cerveau |
| JPH03287537A (ja) * | 1990-03-31 | 1991-12-18 | Yamasa Shoyu Co Ltd | 抗動脈硬化症剤 |
| JP3025559B2 (ja) * | 1990-07-19 | 2000-03-27 | ヤマサ醤油株式会社 | アデノシン誘導体 |
| JP3025557B2 (ja) * | 1991-06-28 | 2000-03-27 | ヤマサ醤油株式会社 | ２‐アルキニルアデノシン誘導体 |
| JP3053908B2 (ja) * | 1991-06-28 | 2000-06-19 | ヤマサ醤油株式会社 | ２‐アルキニルアデノシン誘導体 |
| IT1254915B (it) * | 1992-04-24 | 1995-10-11 | Gloria Cristalli | Derivati di adenosina ad attivita' a2 agonista |
| AU7449598A (en) * | 1997-05-23 | 1998-12-11 | Nippon Shinyaku Co. Ltd. | Medicinal composition for prevention or treatment of hepatopathy |
| EP1014995A4 (en) * | 1997-06-18 | 2005-02-16 | Aderis Pharmaceuticals Inc | COMPOSITIONS AND METHODS FOR PREVENTING RESTENOSES CONSECUTIVE TO REVASCULARIZATION INTERVENTIONS |
| JPH11335302A (ja) * | 1998-05-26 | 1999-12-07 | Toa Eiyo Ltd | 安定な医薬組成物 |
| JP3619017B2 (ja) * | 1998-06-24 | 2005-02-09 | 日本臓器製薬株式会社 | 新規アラビノシルアデニン誘導体 |
| JP2002173427A (ja) * | 1998-09-01 | 2002-06-21 | Yamasa Shoyu Co Ltd | 眼疾患治療用医薬組成物 |
-
2000
- 2000-01-31 CA CA002361614A patent/CA2361614C/en not_active Expired - Fee Related
- 2000-01-31 CN CNB008055092A patent/CN1191266C/zh not_active Expired - Fee Related
- 2000-01-31 SK SK1097-2001A patent/SK284877B6/sk not_active IP Right Cessation
- 2000-01-31 JP JP2000596019A patent/JP4837831B2/ja not_active Expired - Fee Related
- 2000-01-31 DE DE60009665T patent/DE60009665T2/de not_active Expired - Lifetime
- 2000-01-31 UA UA2001086055A patent/UA72912C2/uk unknown
- 2000-01-31 AU AU27454/00A patent/AU778870B2/en not_active Ceased
- 2000-01-31 DK DK00905833T patent/DK1150991T3/da active
- 2000-01-31 MY MYPI20000343A patent/MY129445A/en unknown
- 2000-01-31 BR BR0007864-6A patent/BR0007864A/pt not_active Application Discontinuation
- 2000-01-31 ES ES00905833T patent/ES2215609T3/es not_active Expired - Lifetime
- 2000-01-31 NZ NZ513096A patent/NZ513096A/xx not_active IP Right Cessation
- 2000-01-31 PL PL349644A patent/PL199953B1/pl unknown
- 2000-01-31 EP EP00905833A patent/EP1150991B1/en not_active Expired - Lifetime
- 2000-01-31 HU HU0200224A patent/HU228937B1/hu not_active IP Right Cessation
- 2000-01-31 EE EEP200100397A patent/EE05185B1/xx not_active IP Right Cessation
- 2000-01-31 MX MXPA01007850A patent/MXPA01007850A/es active IP Right Grant
- 2000-01-31 PT PT00905833T patent/PT1150991E/pt unknown
- 2000-01-31 IL IL14418800A patent/IL144188A0/xx unknown
- 2000-01-31 CZ CZ20012781A patent/CZ296404B6/cs not_active IP Right Cessation
- 2000-01-31 KR KR1020017009640A patent/KR100668006B1/ko not_active Expired - Fee Related
- 2000-01-31 WO PCT/US2000/002324 patent/WO2000044763A2/en not_active Ceased
- 2000-01-31 AT AT00905833T patent/ATE263777T1/de active
- 2000-02-01 AR ARP000100433A patent/AR029332A1/es not_active Application Discontinuation
-
2001
- 2001-07-05 IL IL144188A patent/IL144188A/en not_active IP Right Cessation
- 2001-07-13 NO NO20013507A patent/NO321216B1/no not_active IP Right Cessation
-
2005
- 2005-03-23 AU AU2005201255A patent/AU2005201255B2/en not_active Ceased
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