JP2002507410A - ルシフェラーゼ、蛍光タンパク質、ルシフェラーゼおよび蛍光タンパク質をコードする核酸および、診断、高処理スクリーニングおよび新規アイテムにおけるその使用 - Google Patents
ルシフェラーゼ、蛍光タンパク質、ルシフェラーゼおよび蛍光タンパク質をコードする核酸および、診断、高処理スクリーニングおよび新規アイテムにおけるその使用Info
- Publication number
- JP2002507410A JP2002507410A JP2000537980A JP2000537980A JP2002507410A JP 2002507410 A JP2002507410 A JP 2002507410A JP 2000537980 A JP2000537980 A JP 2000537980A JP 2000537980 A JP2000537980 A JP 2000537980A JP 2002507410 A JP2002507410 A JP 2002507410A
- Authority
- JP
- Japan
- Prior art keywords
- luciferase
- gfp
- renilla
- nucleic acid
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0069—Oxidoreductases (1.) acting on single donors with incorporation of molecular oxygen, i.e. oxygenases (1.13)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
- A61K47/6853—Carcino-embryonic antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
- A61K47/6867—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell the tumour determinant being from a cell of a blood cancer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
- C07K14/43595—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from coelenteratae, e.g. medusae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US7962498P | 1998-03-27 | 1998-03-27 | |
US60/079,624 | 1998-03-27 | ||
US8936798P | 1998-06-15 | 1998-06-15 | |
US60/089,367 | 1998-06-15 | ||
US10293998P | 1998-10-01 | 1998-10-01 | |
US60/102,939 | 1998-10-01 | ||
PCT/US1999/006698 WO1999049019A2 (en) | 1998-03-27 | 1999-03-26 | Luciferases, fluorescent proteins, nucleic acids encoding the luciferases and fluorescent proteins and the use thereof in diagnostics |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2009000303A Division JP4923068B2 (ja) | 1998-03-27 | 2009-01-05 | ルシフェラーゼ、蛍光タンパク質、ルシフェラーゼおよび蛍光タンパク質をコードする核酸および、診断、高処理スクリーニングおよび新規アイテムにおけるその使用 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2002507410A true JP2002507410A (ja) | 2002-03-12 |
JP2002507410A5 JP2002507410A5 (US06436682-20020820-C00006.png) | 2008-02-28 |
Family
ID=27373514
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2000537980A Pending JP2002507410A (ja) | 1998-03-27 | 1999-03-26 | ルシフェラーゼ、蛍光タンパク質、ルシフェラーゼおよび蛍光タンパク質をコードする核酸および、診断、高処理スクリーニングおよび新規アイテムにおけるその使用 |
JP2009000303A Expired - Fee Related JP4923068B2 (ja) | 1998-03-27 | 2009-01-05 | ルシフェラーゼ、蛍光タンパク質、ルシフェラーゼおよび蛍光タンパク質をコードする核酸および、診断、高処理スクリーニングおよび新規アイテムにおけるその使用 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2009000303A Expired - Fee Related JP4923068B2 (ja) | 1998-03-27 | 2009-01-05 | ルシフェラーゼ、蛍光タンパク質、ルシフェラーゼおよび蛍光タンパク質をコードする核酸および、診断、高処理スクリーニングおよび新規アイテムにおけるその使用 |
Country Status (8)
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006061906A1 (ja) * | 2004-12-09 | 2006-06-15 | Nec Soft, Ltd. | 新規なルシフェラーゼをコードする遺伝子 |
JP2007520200A (ja) * | 2003-06-25 | 2007-07-26 | ユニターゲッティング リサーチ エイエス | タンパク質発現システム |
JP2008092900A (ja) * | 2006-10-16 | 2008-04-24 | National Institute Of Advanced Industrial & Technology | 2つの分泌ルシフェラーゼ |
WO2010119721A1 (ja) * | 2009-04-17 | 2010-10-21 | 独立行政法人産業技術総合研究所 | 超高輝度で安定な人工生物発光酵素 |
JP2010284131A (ja) * | 2009-06-15 | 2010-12-24 | Chisso Corp | 発光触媒活性を有する融合蛋白質 |
WO2011102178A1 (ja) * | 2010-02-19 | 2011-08-25 | 独立行政法人産業技術総合研究所 | 改良されたレポーター遺伝子を用いる分析システム |
WO2013094359A1 (ja) * | 2011-12-19 | 2013-06-27 | 独立行政法人産業技術総合研究所 | セルロース/キチン系高分子発光材料 |
JP2013543849A (ja) * | 2010-11-08 | 2013-12-09 | ウーハン フアヤオ バイオファーマシューティカル カンパニー リミテッド | 葉酸−抗体コンジュゲートおよびその使用 |
JP2018515076A (ja) * | 2015-05-27 | 2018-06-14 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | 抗菌剤感受性のメカニズム |
Families Citing this family (292)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7090976B2 (en) * | 1999-11-10 | 2006-08-15 | Rigel Pharmaceuticals, Inc. | Methods and compositions comprising Renilla GFP |
US6936421B2 (en) | 1998-10-08 | 2005-08-30 | Rigel Pharmaceuticals, Inc. | Structurally biased random peptide libraries based on different scaffolds |
US7297482B2 (en) | 1998-10-08 | 2007-11-20 | Rigel Pharmaceuticals, Inc. | Structurally biased random peptide libraries based on different scaffolds |
US6180343B1 (en) | 1998-10-08 | 2001-01-30 | Rigel Pharmaceuticals, Inc. | Green fluorescent protein fusions with random peptides |
US20030087492A1 (en) | 2001-11-02 | 2003-05-08 | Promos Technologies, Inc. | Semiconductor device and method of manufacturing the same |
US7338785B2 (en) | 1998-12-11 | 2008-03-04 | Clontech Laboratories, Inc. | Nucleic acids encoding chromophores/fluorophores and methods for using the same |
US9834584B2 (en) | 1998-12-11 | 2017-12-05 | Takara Bio Usa, Inc. | Nucleic acids encoding chromophores/fluorophores and methods for using the same |
AUPP846399A0 (en) | 1999-02-02 | 1999-02-25 | University Of Sydney, The | Pigment protein from coral tissue |
US7135613B1 (en) | 1999-02-18 | 2006-11-14 | The National University Of Singapore | Chimeric gene constructs for generation of fluorescent transgenic ornamental fish |
GB9903767D0 (en) * | 1999-02-18 | 1999-04-14 | Univ Glasgow | Receptor assay |
US6673554B1 (en) * | 1999-06-14 | 2004-01-06 | Trellie Bioinformatics, Inc. | Protein localization assays for toxicity and antidotes thereto |
AU783767B2 (en) * | 1999-10-14 | 2005-12-01 | Takara Bio Usa, Inc. | Anthozoa derived chromophores/fluorophores and methods for using the same |
US20030013849A1 (en) * | 1999-10-29 | 2003-01-16 | Ward William W. | Renilla reniformis green fluorescent protein |
AU1446801A (en) * | 1999-10-29 | 2001-05-14 | Rutgers, The State University Of New Jersey | Renilla reniformis green fluorescent protein |
EP1228233B1 (en) * | 1999-11-10 | 2007-01-10 | Rigel Pharmaceuticals, Inc. | Methods and compositions comprising renilla gfp |
US20040214227A1 (en) * | 1999-12-22 | 2004-10-28 | Erik Joly | Bioluminescence resonance energy transfer (bret) fusion molecule and method of use |
CA2401544A1 (en) * | 2000-02-28 | 2001-09-07 | Stratagene | Renilla reniformis green fluorescent protein and mutants thereof |
US20020064842A1 (en) * | 2000-06-09 | 2002-05-30 | Sorge Joseph A. | Renilla reniformis green fluorescent protein and mutants thereof |
WO2001068824A2 (en) * | 2000-03-15 | 2001-09-20 | Prolume, Ltd. | Renilla reniformis fluorescent proteins, nucleic acids encoding the fluorescent proteins and the use thereof in diagnostics, high throughput screening and novelty items |
US7109315B2 (en) * | 2000-03-15 | 2006-09-19 | Bruce J. Bryan | Renilla reniformis fluorescent proteins, nucleic acids encoding the fluorescent proteins and the use thereof in diagnostics, high throughput screening and novelty items |
JP5389307B2 (ja) * | 2000-06-01 | 2014-01-15 | インスティチュート・パスツール | 単細胞レベルでの生物発光性Ca++リポーターとしてのキメラ性GFP−エクオリン |
WO2001093930A1 (en) * | 2000-06-02 | 2001-12-13 | The University Of Utah Research Foundation | Active needle devices with integrated functionality |
WO2002020749A2 (en) * | 2000-09-07 | 2002-03-14 | Owman Christer S O | Chimeric reporter system for cell surface receptor-ligand binding |
AU1172202A (en) | 2000-10-12 | 2002-04-22 | Clontech Lab Inc | Far red shifted fluorescent proteins |
WO2004026111A2 (en) | 2000-11-16 | 2004-04-01 | Microspherix Llc | Flexible and/or elastic brachytherapy seed or strand |
DE10058091A1 (de) * | 2000-11-23 | 2002-06-06 | Bayer Ag | Isolierte Luziferasen Lu164, LuAL und Lu22, sowie deren Verwendung |
US7091046B2 (en) * | 2000-12-11 | 2006-08-15 | Hk Pharmaceuticals, Inc. | Multiplexed protein expression and activity assay |
US6936428B2 (en) | 2000-12-15 | 2005-08-30 | Stratagene California | Dimeric flourescent polypeptides |
CA2328684A1 (en) * | 2000-12-15 | 2002-06-15 | Yahia Gawad | Photon-triggered luminescent assay |
US6645761B1 (en) | 2000-12-22 | 2003-11-11 | Stratagene | Humanized polynucleotide sequence encoding Renilla mulleri green fluorescent protein |
CA2434293A1 (en) * | 2001-01-29 | 2002-08-08 | Anticancer, Inc. | Fluorescent proteins |
US20040191786A1 (en) * | 2001-02-16 | 2004-09-30 | Yue David T. | Three cube fret method (3-fret) for detecting fluorescence energy transfer |
US6969597B2 (en) | 2001-02-21 | 2005-11-29 | Clontech Laboratories, Inc. | Nucleic acids encoding non aggregating fluorescent proteins and methods for using the same |
US7090994B2 (en) * | 2001-03-07 | 2006-08-15 | Xenogen Corporation | Methods of screening for introduction of DNA into a target cell |
US7244232B2 (en) * | 2001-03-07 | 2007-07-17 | Biomed Solutions, Llc | Process for identifying cancerous and/or metastatic cells of a living organism |
WO2002072789A2 (en) * | 2001-03-12 | 2002-09-19 | Irm, Llc. | Genomics-driven high speed cellular assays, development thereof, and collections of cellular reporters |
WO2002072783A2 (en) * | 2001-03-12 | 2002-09-19 | Irm, Llc | Identification of cellular targets for biologically active molecules |
SE0101519D0 (sv) * | 2001-04-27 | 2001-04-27 | Astrazeneca Ab | Nucleic ACID |
US20050009205A1 (en) * | 2003-07-11 | 2005-01-13 | Ye Fang | Fluorescent ligands for GPCR arrays |
US6780974B2 (en) * | 2001-06-12 | 2004-08-24 | Cellomics, Inc. | Synthetic DNA encoding an orange seapen-derived green fluorescent protein with codon preference of mammalian expression systems and biosensors |
US7553939B2 (en) * | 2001-06-29 | 2009-06-30 | The Board Of Trustees Of The Leland Stanford Junior University | T cell regulatory genes and methods of use thereof |
US8709412B2 (en) | 2001-06-29 | 2014-04-29 | The Board Of Trustees Of The Leland Stanford Junior University | Modulation of TIM receptor activity in combination with cytoreductive therapy |
US7393656B2 (en) | 2001-07-10 | 2008-07-01 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for risk stratification |
US6544729B2 (en) * | 2001-07-20 | 2003-04-08 | University Of Tennessee | Bioluminescent biosensor device |
US20030053951A1 (en) * | 2001-07-26 | 2003-03-20 | Millennium Pharmaceuticals, Inc. | Use of non-invasive imaging technologies to monitor in vivo gene-expression |
US8048644B1 (en) * | 2001-08-01 | 2011-11-01 | The University Of North Carolina At Charlotte | Biological indicator for monitoring the transport of micro-organisms in the environment |
DE60223937T2 (de) | 2001-10-12 | 2008-11-27 | Clontech Laboratories, Inc., Mountain View | Nukleinsäuren kodierend miteinander verbundene chromo/fluoreszenzdomänen und verfahren zu ihrer verwendung |
WO2003033650A2 (en) * | 2001-10-15 | 2003-04-24 | Stratagene | Recombinant renilla reniformis system for bioluminescence resonance energy transfer |
US7268229B2 (en) * | 2001-11-02 | 2007-09-11 | Promega Corporation | Compounds to co-localize luminophores with luminescent proteins |
JP2005509420A (ja) | 2001-11-13 | 2005-04-14 | クローンテック ラボラトリーズ インク. | 新規発色団/蛍光発色団およびそれらの使用法 |
US6815178B1 (en) * | 2001-11-19 | 2004-11-09 | Antony R. Shoaf | Endospore detection method |
DE10158904A1 (de) * | 2001-11-30 | 2003-06-12 | Roche Diagnostics Gmbh | Verfahren zur Herstellung von linearen DNA Fragmenten für die in vitro Expression von Proteinen |
EP1456223B1 (en) | 2001-12-19 | 2009-08-12 | The University Of Chicago | Rapidly maturing fluorescent proteins and methods for using the same |
WO2003057833A2 (en) * | 2001-12-26 | 2003-07-17 | Clontech Laboratories, Inc. | Mutant chromophores/fluorophores and methods for making and using the same |
US20040048311A1 (en) * | 2002-01-24 | 2004-03-11 | Dana Ault-Riche | Use of collections of binding sites for sample profiling and other applications |
CA2478298A1 (en) * | 2002-03-07 | 2003-09-12 | Zephyr Proteomix Ltd. | Microarrays of cellulose binding chimeric proteins and methods of use thereof |
AU2003224694A1 (en) * | 2002-03-25 | 2003-10-13 | Chemicon International Inc. | Modified aequorins having enhanced glowing kinetics and methods of using same |
US7351542B2 (en) | 2002-05-20 | 2008-04-01 | The Regents Of The University Of California | Methods of modulating tubulin deacetylase activity |
DE10225932B4 (de) * | 2002-06-11 | 2007-01-11 | Deutsches Krebsforschungszentrum (Dkfz) | Bildgebendes Verfahren und Vorrichtung zu dessen Durchführung |
JP2005532071A (ja) * | 2002-07-10 | 2005-10-27 | ストラタジーン カリフォルニア | 足場としてのヒト化レニラ・レニフォルミス緑色蛍光タンパク質 |
CN1695058B (zh) | 2002-09-09 | 2011-04-13 | 生命树股份有限公司 | 诊断宫颈癌的方法 |
US9453251B2 (en) | 2002-10-08 | 2016-09-27 | Pfenex Inc. | Expression of mammalian proteins in Pseudomonas fluorescens |
US20040209282A1 (en) * | 2002-10-30 | 2004-10-21 | Dana Ault-Riche | Methods for producing polypeptide-tagged collections and capture systems containing the tagged polypeptides |
EP2100958A1 (en) | 2002-11-12 | 2009-09-16 | Zakrytoe Aktsionernoe Obschestvo 'Evrogen' | Fluorescent proteins and chromoproteins from non-aequorea hydrozoa species and methods for using same |
US20040209370A1 (en) * | 2002-12-19 | 2004-10-21 | Wonchul Suh | Method for chromosomal engineering |
DK1576157T3 (da) * | 2002-12-26 | 2010-11-01 | Zakrytoe Aktsionernoe Obschest | Fluorescerende proteiner fra Copepode-arter og fremgangsmåder til anvendelse af samme |
WO2004071641A2 (en) * | 2003-02-10 | 2004-08-26 | Pointilliste, Inc. | Self-assembling arrays and uses thereof |
WO2004076685A2 (en) * | 2003-02-28 | 2004-09-10 | Lux Biotechnology Limited | Fungal biosensor and assay |
WO2004081189A2 (en) * | 2003-03-07 | 2004-09-23 | Stanford University | Multimodality imaging of reporter gene expression using a novel fusion vector in living cells and organisms |
WO2004090115A2 (en) * | 2003-04-04 | 2004-10-21 | Stratagene | Renilla gfp mutants with increased fluorescent intensity and special shift |
GB2400659B8 (en) * | 2003-04-17 | 2007-07-09 | Cambrex Bio Science Nottingham | Assay methods and materials |
WO2004096998A2 (en) * | 2003-04-29 | 2004-11-11 | Vanderbilt University | Nanoparticular tumor targeting and therapy |
EP1626988A2 (en) * | 2003-05-16 | 2006-02-22 | Receptor Biologix, Inc. | Intron fusion proteins, and methods of identifying and using same |
WO2005019252A2 (en) | 2003-05-22 | 2005-03-03 | University Of Florida Research Foundation, Inc. | Novel fluorescent and colored proteins, and polynucleotides that encode these proteins |
EP1639141B1 (en) | 2003-06-10 | 2011-04-20 | The J. David Gladstone Institutes | Methods for treating lentivirus infections |
US8399618B2 (en) | 2004-10-21 | 2013-03-19 | Xencor, Inc. | Immunoglobulin insertions, deletions, and substitutions |
US8883147B2 (en) | 2004-10-21 | 2014-11-11 | Xencor, Inc. | Immunoglobulins insertions, deletions, and substitutions |
US20050095648A1 (en) * | 2003-10-30 | 2005-05-05 | Mario Geysen | Method for designing linear epitopes and algorithm therefor and polypeptide epitopes |
US7166154B2 (en) * | 2003-11-06 | 2007-01-23 | Hewlett-Packard Development Company, L.P. | System and a method for an edible, optically invisible ink |
WO2005067980A2 (en) * | 2004-01-12 | 2005-07-28 | Pointilliste, Inc. | Design of therapeutics and therapeutics |
US20050217527A1 (en) * | 2004-02-06 | 2005-10-06 | Ciesiun Paul M | Bioluminescent paintball |
US7481997B1 (en) | 2004-02-12 | 2009-01-27 | Montana State University | Snow mountain virus genome sequence, virus-like particles and methods of use |
EP1732944B1 (en) | 2004-04-07 | 2012-09-05 | The University of Chicago | Monomeric red fluorescent proteins |
WO2005113596A2 (en) * | 2004-05-14 | 2005-12-01 | Receptor Biologix, Inc. | Cell surface receptor isoforms and methods of identifying and using the same |
EP2412816B1 (en) | 2004-07-26 | 2014-12-03 | Pfenex Inc. | Process for improved protein expression by strain engineering |
US20060044781A1 (en) * | 2004-08-31 | 2006-03-02 | Hanley Brian P | Bioluminescent fog for military and law enforcement |
US7399607B2 (en) * | 2004-09-22 | 2008-07-15 | Allergan, Inc. | Fluorescence polarization assays for determining clostridial toxin activity |
KR101019525B1 (ko) | 2004-11-12 | 2011-03-07 | 젠코어 인코포레이티드 | FcRn에 대한 변경된 결합성을 갖는 Fc 변이체 |
US8802820B2 (en) | 2004-11-12 | 2014-08-12 | Xencor, Inc. | Fc variants with altered binding to FcRn |
US20060127455A1 (en) * | 2004-12-14 | 2006-06-15 | Yorktown Technologies, Inc. | Optimized food for expressing luminescent proteins in animals |
US7230080B2 (en) | 2005-02-16 | 2007-06-12 | University Of Florida Research Foundation, Inc. | Fluorescent and colored proteins, and polynucleotides that encode these proteins |
CA2600129A1 (en) * | 2005-03-07 | 2006-09-14 | Rampyari Raja Walia | Enhancing a luminescent signal |
US8153435B1 (en) | 2005-03-30 | 2012-04-10 | Tracer Detection Technology Corp. | Methods and articles for identifying objects using encapsulated perfluorocarbon tracers |
WO2006119510A2 (en) * | 2005-05-04 | 2006-11-09 | Receptor Biologix, Inc. | Isoforms of receptor for advanced glycation end products (rage) and methods of identifying and using same |
US20090170769A1 (en) * | 2005-05-13 | 2009-07-02 | Pei Jin | Cell surface receptor isoforms and methods of identifying and using the same |
ES2371664T3 (es) * | 2005-06-03 | 2012-01-09 | Beacon Biotechnology Llc | Ensayo de ácidos nucleicos de proximidad de quimioluminiscencia. |
WO2007035213A2 (en) | 2005-08-09 | 2007-03-29 | Revivicor, Inc. | Transgenic ungulates expressing ctla4-ig and uses thereof |
EP1945761B1 (en) | 2005-08-19 | 2011-09-28 | Commonwealth Scientific and Industrial Research Organisation | Arachnocampa luciferases |
JP2009515520A (ja) * | 2005-11-10 | 2009-04-16 | レセプター バイオロジックス, インコーポレイテッド | 肝細胞成長因子イントロン融合蛋白 |
EP1785434A1 (en) * | 2005-11-11 | 2007-05-16 | Ludwig-Maximilians-Universität München | Targeting and tracing of antigens in living cells |
US10183986B2 (en) | 2005-12-15 | 2019-01-22 | Industrial Technology Research Institute | Trimeric collagen scaffold antibodies |
US20070161031A1 (en) * | 2005-12-16 | 2007-07-12 | The Board Of Trustees Of The Leland Stanford Junior University | Functional arrays for high throughput characterization of gene expression regulatory elements |
EP2037270A3 (en) * | 2006-03-31 | 2009-03-25 | F. Hoffmann-La Roche Ag | Tumor models employing green fluorescent protein |
US20100003189A1 (en) | 2006-07-14 | 2010-01-07 | The Regents Of The University Of California | Cancer biomarkers and methods of use thereof |
US20080293086A1 (en) * | 2006-09-18 | 2008-11-27 | Cobalt Technologies, Inc. A Delaware Corporation | Real time monitoring of microbial enzymatic pathways |
US7767206B2 (en) | 2006-10-02 | 2010-08-03 | Amgen Inc. | Neutralizing determinants of IL-17 Receptor A and antibodies that bind thereto |
US20080081332A1 (en) * | 2006-10-03 | 2008-04-03 | Jun Amano | Methods and devices for conducting diagnostic testing |
US20100035287A1 (en) * | 2006-10-12 | 2010-02-11 | The General Hospital Corporation | Secreted Luciferase Fluorescent Protein Conjugate Nucleic Acid Construct and Uses Thereof |
US20080090263A1 (en) * | 2006-10-13 | 2008-04-17 | National Institute Of Advanced Industrial Science And Technology | Two secretory luciferases |
WO2008112127A2 (en) * | 2007-03-08 | 2008-09-18 | Switchgear Genomics | Functional arrays for high throughput characterization of regulatory elements in untranslated regions of genes |
US7960139B2 (en) | 2007-03-23 | 2011-06-14 | Academia Sinica | Alkynyl sugar analogs for the labeling and visualization of glycoconjugates in cells |
US9394571B2 (en) | 2007-04-27 | 2016-07-19 | Pfenex Inc. | Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins |
US9580719B2 (en) | 2007-04-27 | 2017-02-28 | Pfenex, Inc. | Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins |
US8727554B2 (en) | 2007-06-25 | 2014-05-20 | Yorktown Technologies, L.P. | Aquarium with adjustable lighting |
US20090006219A1 (en) * | 2007-06-29 | 2009-01-01 | Alan Blake | Method for distribution of an aquarium kit |
RS56743B1 (sr) | 2007-08-21 | 2018-03-30 | Amgen Inc | Humani c-fms antigen vezujući proteini |
WO2009025847A2 (en) | 2007-08-21 | 2009-02-26 | Nodality, Inc. | Methods for diagnosis, prognosis and methods of treatment |
US8431698B2 (en) * | 2007-08-29 | 2013-04-30 | Biolume Inc. | Bioluminescent endoscopy methods and compounds |
US20090081715A1 (en) * | 2007-09-07 | 2009-03-26 | Cobalt Technologies, Inc., A Delaware Corporation | Engineered Light-Emitting Reporter Genes |
TW200918553A (en) | 2007-09-18 | 2009-05-01 | Amgen Inc | Human GM-CSF antigen binding proteins |
KR101670621B1 (ko) | 2007-10-02 | 2016-10-28 | 테라노스, 인코포레이티드 | 모듈러 현장 진료 장치 및 이의 용도 |
WO2009086320A1 (en) | 2007-12-26 | 2009-07-09 | Xencor, Inc | Fc variants with altered binding to fcrn |
US8679749B2 (en) | 2007-11-01 | 2014-03-25 | The University Of Chicago | Red fluorescent proteins with enhanced bacterial expression, increased brightness and reduced aggregation |
US20090236541A1 (en) * | 2008-03-24 | 2009-09-24 | General Electric Company | System and Methods for Optical Imaging |
CA2721076A1 (en) | 2008-04-09 | 2009-10-15 | Cobalt Technologies, Inc. | Immobilized product tolerant microorganisms |
JP5986745B2 (ja) | 2008-07-15 | 2016-09-06 | アカデミア シニカAcademia Sinica | Ptfe様のアルミニウム・コート・ガラススライド上のグリカンアレイおよび関連する方法 |
US8309306B2 (en) | 2008-11-12 | 2012-11-13 | Nodality, Inc. | Detection composition |
JO3382B1 (ar) | 2008-12-23 | 2019-03-13 | Amgen Inc | أجسام مضادة ترتبط مع مستقبل cgrp بشري |
NZ593294A (en) | 2009-01-29 | 2013-04-26 | Commw Scient Ind Res Org | Measuring g protein coupled receptor activation |
JP5572972B2 (ja) * | 2009-03-16 | 2014-08-20 | Jnc株式会社 | インスリン分泌促進剤などの薬物のスクリーニング方法 |
US8242248B2 (en) | 2009-03-23 | 2012-08-14 | Nodality, Inc. | Kits for multiparametric phospho analysis |
CN102482690A (zh) * | 2009-06-26 | 2012-05-30 | 钴技术有限公司 | 生物产物生产的集成系统和方法 |
WO2011002924A2 (en) | 2009-06-30 | 2011-01-06 | The General Hospital Corporation | Gaussia luciferase variant for high-throughput screening |
US8207651B2 (en) | 2009-09-16 | 2012-06-26 | Tyco Healthcare Group Lp | Low energy or minimum disturbance method for measuring frequency response functions of ultrasonic surgical devices in determining optimum operating point |
US8815779B2 (en) * | 2009-09-16 | 2014-08-26 | SwitchGear Genomics, Inc. | Transcription biomarkers of biological responses and methods |
TW201117824A (en) | 2009-10-12 | 2011-06-01 | Amgen Inc | Use of IL-17 receptor a antigen binding proteins |
US11377485B2 (en) | 2009-12-02 | 2022-07-05 | Academia Sinica | Methods for modifying human antibodies by glycan engineering |
US10087236B2 (en) | 2009-12-02 | 2018-10-02 | Academia Sinica | Methods for modifying human antibodies by glycan engineering |
UA109888C2 (uk) | 2009-12-07 | 2015-10-26 | ІЗОЛЬОВАНЕ АНТИТІЛО АБО ЙОГО ФРАГМЕНТ, ЩО ЗВ'ЯЗУЄТЬСЯ З β-КЛОТО, РЕЦЕПТОРАМИ FGF І ЇХНІМИ КОМПЛЕКСАМИ | |
JP5764921B2 (ja) * | 2009-12-24 | 2015-08-19 | Jnc株式会社 | 発光活性を有する融合蛋白質 |
WO2011130332A1 (en) | 2010-04-12 | 2011-10-20 | Academia Sinica | Glycan arrays for high throughput screening of viruses |
JP2013523184A (ja) | 2010-04-15 | 2013-06-17 | アムジエン・インコーポレーテツド | ヒトFGF受容体およびβ−KLOTHO結合性タンパク質 |
EP2564200B8 (en) | 2010-04-27 | 2019-10-02 | The Regents of The University of California | Cancer biomarkers and methods of use thereof |
WO2012030738A2 (en) | 2010-08-30 | 2012-03-08 | Beckman Coulter, Inc. | Complex phosphoprotein activation profiles |
JP2012110283A (ja) * | 2010-11-25 | 2012-06-14 | Olympus Corp | 発光タンパク質およびカルシウム応答性セレンテラジン結合タンパク質並びにこれらを用いた研究方法 |
US10428317B2 (en) | 2010-12-03 | 2019-10-01 | Gene Stream Pty Ltd | Light-emitting molecules |
JP5945282B2 (ja) | 2011-01-21 | 2016-07-05 | セラノス, インコーポレイテッド | 試料使用の極大化のためのシステム及び方法 |
WO2012155071A1 (en) | 2011-05-12 | 2012-11-15 | Gilead Biologics, Inc. | Methods of identifying lysyl oxidase - like - 2 (loxl2) binding partners |
US9574002B2 (en) | 2011-06-06 | 2017-02-21 | Amgen Inc. | Human antigen binding proteins that bind to a complex comprising β-Klotho and an FGF receptor |
WO2012178136A2 (en) | 2011-06-24 | 2012-12-27 | University Of Houston System | Fusion proteins of bacterial luciferase as multicolor luminescent sensors |
US20140234330A1 (en) | 2011-07-22 | 2014-08-21 | Amgen Inc. | Il-17 receptor a is required for il-17c biology |
US9619627B2 (en) | 2011-09-25 | 2017-04-11 | Theranos, Inc. | Systems and methods for collecting and transmitting assay results |
US9664702B2 (en) | 2011-09-25 | 2017-05-30 | Theranos, Inc. | Fluid handling apparatus and configurations |
US8475739B2 (en) | 2011-09-25 | 2013-07-02 | Theranos, Inc. | Systems and methods for fluid handling |
US8435738B2 (en) | 2011-09-25 | 2013-05-07 | Theranos, Inc. | Systems and methods for multi-analysis |
US20140170735A1 (en) | 2011-09-25 | 2014-06-19 | Elizabeth A. Holmes | Systems and methods for multi-analysis |
US8840838B2 (en) | 2011-09-25 | 2014-09-23 | Theranos, Inc. | Centrifuge configurations |
US9632102B2 (en) | 2011-09-25 | 2017-04-25 | Theranos, Inc. | Systems and methods for multi-purpose analysis |
US9268915B2 (en) | 2011-09-25 | 2016-02-23 | Theranos, Inc. | Systems and methods for diagnosis or treatment |
EP2758437B1 (en) | 2011-09-22 | 2020-06-03 | Amgen Inc. | Cd27l antigen binding proteins |
US10012664B2 (en) | 2011-09-25 | 2018-07-03 | Theranos Ip Company, Llc | Systems and methods for fluid and component handling |
US9250229B2 (en) | 2011-09-25 | 2016-02-02 | Theranos, Inc. | Systems and methods for multi-analysis |
US9810704B2 (en) | 2013-02-18 | 2017-11-07 | Theranos, Inc. | Systems and methods for multi-analysis |
CA2858572C (en) | 2011-12-08 | 2023-01-17 | Amgen Inc. | Human lcat antigen binding proteins and their use in therapy |
US8435777B1 (en) | 2012-01-20 | 2013-05-07 | Cayla | CPG-free gene for a new secreted reporter protein |
US20150329505A1 (en) * | 2012-01-31 | 2015-11-19 | Bioconst Pty Ltd | A fluorescent composition for use in marking objects, such as flowers |
US10130714B2 (en) | 2012-04-14 | 2018-11-20 | Academia Sinica | Enhanced anti-influenza agents conjugated with anti-inflammatory activity |
AU2013204332B2 (en) | 2012-04-16 | 2015-07-16 | Commonwealth Scientific And Industrial Research Organisation | Methods and systems for detecting an analyte or classifying a sample |
AR091069A1 (es) | 2012-05-18 | 2014-12-30 | Amgen Inc | Proteinas de union a antigeno dirigidas contra el receptor st2 |
US9645151B2 (en) | 2012-08-17 | 2017-05-09 | California Institute Of Technology | Targeting phosphofructokinase and its glycosylation form for cancer |
AU2013306098A1 (en) | 2012-08-18 | 2015-02-12 | Academia Sinica | Cell-permeable probes for identification and imaging of sialidases |
US9624425B2 (en) | 2012-09-01 | 2017-04-18 | Prolume, Ltd. | Substituted benzo[f]imidazo[1,2-a]quinoxalines and imidazo[1,2-a]pyrazines |
CA2889765C (en) | 2012-10-26 | 2021-06-22 | Minna D. BALBAS | Androgen receptor variants and methods for making and using |
TW201425336A (zh) | 2012-12-07 | 2014-07-01 | Amgen Inc | Bcma抗原結合蛋白質 |
ES2728936T3 (es) | 2013-01-25 | 2019-10-29 | Amgen Inc | Anticuerpos dirigidos contra CDH19 para melanoma |
JO3519B1 (ar) | 2013-01-25 | 2020-07-05 | Amgen Inc | تركيبات أجسام مضادة لأجل cdh19 و cd3 |
US20140271629A1 (en) | 2013-03-14 | 2014-09-18 | Amgen Inc. | Chrdl-1 antigen binding proteins and methods of treatment |
PL2970449T3 (pl) | 2013-03-15 | 2020-04-30 | Amgen Research (Munich) Gmbh | Jednołańcuchowe cząsteczki wiążące zawierające N-końcowy ABP |
EP2970446A1 (en) | 2013-03-15 | 2016-01-20 | Amgen Research (Munich) GmbH | Antibody constructs for influenza m2 and cd3 |
TW201902931A (zh) | 2013-03-15 | 2019-01-16 | 美商安美基公司 | 人類pac1抗體 |
US9070175B2 (en) | 2013-03-15 | 2015-06-30 | Panera, Llc | Methods and apparatus for facilitation of a food order |
WO2014144553A1 (en) | 2013-03-15 | 2014-09-18 | Amgen Inc. | Secreted frizzle-related protein 5 (sfrp5) binding proteins and methods of treatment |
US9159094B2 (en) | 2013-03-15 | 2015-10-13 | Panera, Llc | Methods and apparatus for facilitation of orders of food items |
JP6243521B2 (ja) | 2013-05-30 | 2017-12-06 | キニクサ ファーマシューティカルズ, リミテッド | オンコスタチンm受容体抗原結合タンパク質 |
US10086054B2 (en) | 2013-06-26 | 2018-10-02 | Academia Sinica | RM2 antigens and use thereof |
EP3013347B1 (en) | 2013-06-27 | 2019-12-11 | Academia Sinica | Glycan conjugates and use thereof |
US10227370B2 (en) | 2013-08-02 | 2019-03-12 | California Institute Of Technology | Heparan sulfate/heparin mimetics with anti-chemokine and anti-inflammatory activity |
US9770461B2 (en) | 2013-08-02 | 2017-09-26 | California Institute Of Technology | Tailored glycopolymers as anticoagulant heparin mimetics |
TW201605896A (zh) | 2013-08-30 | 2016-02-16 | 安美基股份有限公司 | Gitr抗原結合蛋白 |
CN105682666B (zh) | 2013-09-06 | 2021-06-01 | 中央研究院 | 使用醣脂激活人类iNKT细胞 |
AR097648A1 (es) | 2013-09-13 | 2016-04-06 | Amgen Inc | Combinación de factores epigenéticos y compuestos biespecíficos que tienen como diana cd33 y cd3 en el tratamiento de leucemia mieloide |
US9798987B2 (en) | 2013-09-20 | 2017-10-24 | Panera, Llc | Systems and methods for analyzing restaurant operations |
US10019686B2 (en) | 2013-09-20 | 2018-07-10 | Panera, Llc | Systems and methods for analyzing restaurant operations |
US9257150B2 (en) | 2013-09-20 | 2016-02-09 | Panera, Llc | Techniques for analyzing operations of one or more restaurants |
TW201620939A (zh) | 2014-01-16 | 2016-06-16 | 中央研究院 | 治療及檢測癌症之組合物及方法 |
US10150818B2 (en) | 2014-01-16 | 2018-12-11 | Academia Sinica | Compositions and methods for treatment and detection of cancers |
JP6619745B2 (ja) | 2014-02-20 | 2019-12-11 | アラーガン、インコーポレイテッドAllergan,Incorporated | 補体成分c5抗体 |
EP3110845A1 (en) | 2014-02-27 | 2017-01-04 | Allergan, Inc. | Complement factor bb antibodies |
TWI797430B (zh) | 2014-03-27 | 2023-04-01 | 中央研究院 | 反應性標記化合物及其用途 |
AU2015267045B2 (en) | 2014-05-27 | 2021-02-25 | Academia Sinica | Anti-HER2 glycoantibodies and uses thereof |
US10118969B2 (en) | 2014-05-27 | 2018-11-06 | Academia Sinica | Compositions and methods relating to universal glycoforms for enhanced antibody efficacy |
KR20170003720A (ko) | 2014-05-27 | 2017-01-09 | 아카데미아 시니카 | 항-cd20 글리코항체 및 이의 용도 |
CA2950423A1 (en) | 2014-05-27 | 2015-12-03 | Academia Sinica | Compositions and methods relating to universal glycoforms for enhanced antibody efficacy |
EP3154582A4 (en) | 2014-05-28 | 2018-01-10 | Academia Sinica | Anti-tnf-alpha glycoantibodies and uses thereof |
EP3174903B1 (en) | 2014-07-31 | 2024-04-10 | Amgen Research (Munich) GmbH | Bispecific single chain antibody construct with enhanced tissue distribution |
AR101669A1 (es) | 2014-07-31 | 2017-01-04 | Amgen Res (Munich) Gmbh | Constructos de anticuerpos para cdh19 y cd3 |
TW201609812A (zh) | 2014-07-31 | 2016-03-16 | 安美基研究(慕尼黑)公司 | 最佳化之跨物種特異性雙特異性單鏈抗體構築體 |
WO2016040369A2 (en) | 2014-09-08 | 2016-03-17 | Academia Sinica | HUMAN iNKT CELL ACTIVATION USING GLYCOLIPIDS |
JP6824594B2 (ja) * | 2014-09-11 | 2021-02-03 | Jnc株式会社 | 合成遺伝子の設計方法 |
WO2016040767A2 (en) | 2014-09-12 | 2016-03-17 | Amgen Inc. | Chrdl-1 epitopes and antibodies |
EP3227687A4 (en) | 2014-12-05 | 2018-10-24 | Prelude, Inc. | Dcis recurrence and invasive breast cancer |
US9975965B2 (en) | 2015-01-16 | 2018-05-22 | Academia Sinica | Compositions and methods for treatment and detection of cancers |
US10495645B2 (en) | 2015-01-16 | 2019-12-03 | Academia Sinica | Cancer markers and methods of use thereof |
EP3789766A1 (en) | 2015-01-24 | 2021-03-10 | Academia Sinica | Novel glycan conjugates and methods of use thereof |
US10544210B2 (en) | 2015-02-03 | 2020-01-28 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Anti-Rho GTPase conformational single domain antibodies and uses thereof |
EP3056902B1 (en) | 2015-02-16 | 2020-04-01 | Universite De Bordeaux | Novel voltage dependent ion channel fusions and method of use thereof |
MX2017013348A (es) | 2015-04-17 | 2018-08-01 | Amgen Res Munich Gmbh | Construcciones de anticuerpos biespecificos contra cdh3 y cd3. |
WO2016189118A1 (en) | 2015-05-28 | 2016-12-01 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods of prognosis and treatment of patients suffering from acute myeloid leukemia |
US10782304B2 (en) | 2015-06-24 | 2020-09-22 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for detecting protein-protein interactions |
TWI744242B (zh) | 2015-07-31 | 2021-11-01 | 德商安美基研究(慕尼黑)公司 | Egfrviii及cd3抗體構築體 |
TWI796283B (zh) | 2015-07-31 | 2023-03-21 | 德商安美基研究(慕尼黑)公司 | Msln及cd3抗體構築體 |
TWI829617B (zh) | 2015-07-31 | 2024-01-21 | 德商安美基研究(慕尼黑)公司 | Flt3及cd3抗體構築體 |
TW202346349A (zh) | 2015-07-31 | 2023-12-01 | 德商安美基研究(慕尼黑)公司 | Dll3及cd3抗體構築體 |
TWI717375B (zh) | 2015-07-31 | 2021-02-01 | 德商安美基研究(慕尼黑)公司 | Cd70及cd3抗體構築體 |
US11273167B2 (en) | 2015-08-03 | 2022-03-15 | The Regents Of The University Of California | Compositions and methods for modulating ABHD2 activity |
PE20181327A1 (es) | 2015-12-23 | 2018-08-20 | Amgen Inc | Metodo para tratar o mejorar trastornos metabolicos con proteinas de union para el receptor peptidico inhibidor gastrico (gipr) en combinacion con agonistas de glp-1 |
TWI797073B (zh) | 2016-01-25 | 2023-04-01 | 德商安美基研究(慕尼黑)公司 | 包含雙特異性抗體建構物之醫藥組合物 |
KR101661913B1 (ko) * | 2016-01-29 | 2016-10-04 | (주)넥스젠바이오텍 | 해파리 유래 녹색형광단백질을 유효성분으로 포함하는 항산화 활성을 갖는 화장료 조성물 |
KR101661912B1 (ko) * | 2016-01-29 | 2016-10-04 | (주)넥스젠바이오텍 | 녹색형광단백질-인간 상피세포재생인자 융합단백질을 유효성분으로 포함하는 주름 개선 및 항노화 화장료 조성물 |
EA039859B1 (ru) | 2016-02-03 | 2022-03-21 | Эмджен Рисерч (Мюник) Гмбх | Биспецифические конструкты антител, связывающие egfrviii и cd3 |
UA126657C2 (uk) | 2016-02-03 | 2023-01-11 | Емджен Рісерч (Мюнік) Ґмбг | ОДНОЛАНЦЮГОВА КОНСТРУКЦІЯ АНТИТІЛА ДО BCMA І CD3<font face="Symbol">e</font> |
BR112018015415A2 (pt) | 2016-02-03 | 2018-12-18 | Amgen Res Munich Gmbh | célula t biespecífica de psma e cd3 de engate de construtos de anticorpos |
JP2019515876A (ja) | 2016-03-08 | 2019-06-13 | アカデミア シニカAcademia Sinica | N−グリカンおよびそのアレイのモジュール合成のための方法 |
CN105861559B (zh) | 2016-04-11 | 2018-05-01 | 苏州奥特铭医药科技有限公司 | 一种能直接反应i型干扰素应答的慢病毒载体及其制备方法与应用 |
US20190120838A1 (en) | 2016-04-13 | 2019-04-25 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Methods and kits for the rapid detection of the escherichia coli o25b-st131 clone |
JOP20170091B1 (ar) | 2016-04-19 | 2021-08-17 | Amgen Res Munich Gmbh | إعطاء تركيبة ثنائية النوعية ترتبط بـ cd33 وcd3 للاستخدام في طريقة لعلاج اللوكيميا النخاعية |
KR101913163B1 (ko) | 2016-06-30 | 2018-11-01 | 주식회사 바이오이즈 | 이중가닥 핵산 신호 프로브 및 이를 이용한 표적분자의 검출방법 |
CN109963868B (zh) | 2016-08-22 | 2023-11-14 | 醣基生医股份有限公司 | 抗体、结合片段及使用方法 |
US10385319B2 (en) | 2016-09-08 | 2019-08-20 | The Governement of the United States of America, as represented by the Secretary of Homeland Security | Modified foot-and-mouth disease virus 3C proteases, compositions and methods thereof |
US10435695B2 (en) * | 2016-09-08 | 2019-10-08 | The Government of the United States of America, as represented by the Secretary of Homeland Security | Fusion protein comprising Gaussia luciferase, translation interrupter sequence, and interferon amino acid sequences |
FI3529616T3 (fi) | 2016-10-20 | 2023-12-04 | Harvard College | In vitro- ja solupohjaisia testejä botuliinineurotoksiinien aktiivisuuden mittaamiseksi |
EP3538665B1 (en) | 2016-11-14 | 2024-01-03 | PPB Technology Pty Ltd | Protease sensor molecules |
JOP20190177A1 (ar) | 2017-01-17 | 2019-07-16 | Amgen Inc | طريقة لعلاج أو تحسين اضطرابات أيضية باستخدام مساعدات مستقبل glp-1 مقترنة بمناهضات لمستقبل ببتيد مثبط معوي (gipr) |
JOP20190189A1 (ar) | 2017-02-02 | 2019-08-01 | Amgen Res Munich Gmbh | تركيبة صيدلانية ذات درجة حموضة منخفضة تتضمن بنيات جسم مضاد يستهدف الخلية t |
CN110461871B (zh) | 2017-02-16 | 2024-04-26 | 索纳特生物疗法公司 | 白蛋白结合结构域融合蛋白 |
KR102018248B1 (ko) * | 2017-03-15 | 2019-09-05 | 한양대학교 산학협력단 | 생물발광 강도가 증폭된 변이 가우시아 루시퍼라아제 |
MX2019012017A (es) | 2017-04-07 | 2020-02-12 | Juno Therapeutics Inc | Celulas modificadas que expresan antigeno de membrana especifico de prostata (psma) o una forma modificada del mismo y metodos relacionados. |
JP7325936B2 (ja) | 2017-05-05 | 2023-08-15 | アムジエン・インコーポレーテツド | 改善された貯蔵及び投与のための、二重特異性抗体構築物を含む医薬組成物 |
JOP20190259A1 (ar) | 2017-05-31 | 2019-10-31 | Amgen Inc | بروتينات ربط مولد ضد مضادة لـ jagged1 |
UY37753A (es) | 2017-06-02 | 2018-11-30 | Amgen Inc | Antagonistas de péptido pac1 |
EA201992502A1 (ru) | 2017-06-20 | 2020-04-22 | Эмджен Инк. | Способ лечения или уменьшения интенсивности метаболических нарушений с применением белков, связывающих рецептор гастроингибиторного пептида (gipr), в комбинации с агонистами glp-1 |
MX2020001327A (es) | 2017-08-04 | 2020-03-20 | Amgen Inc | Metodo de conjugacion de cys-acm. |
EP3665481B1 (en) | 2017-08-08 | 2023-10-11 | PPB Technology Pty Ltd | Carbohydrate sensors |
CN111164226A (zh) | 2017-10-18 | 2020-05-15 | 蒙特利尔大学 | 评估g蛋白活化的系统和方法 |
US11851679B2 (en) | 2017-11-01 | 2023-12-26 | Juno Therapeutics, Inc. | Method of assessing activity of recombinant antigen receptors |
AU2018383679A1 (en) | 2017-12-11 | 2020-05-07 | Amgen Inc. | Continuous manufacturing process for bispecific antibody products |
TW201940518A (zh) | 2017-12-29 | 2019-10-16 | 美商安進公司 | 針對muc17和cd3之雙特異性抗體構建體 |
CA3004436C (en) | 2018-05-09 | 2021-06-01 | Paige Whitehead | Biodegradable light wand |
AU2019313444A1 (en) | 2018-07-30 | 2021-02-18 | Amgen Inc. | Prolonged administration of a bispecific antibody construct binding to CD33 and CD3 |
TWI830761B (zh) | 2018-08-03 | 2024-02-01 | 德商安美基研究(慕尼黑)公司 | 針對cldn18.2和cd3之抗體構建體 |
AU2019339508A1 (en) | 2018-09-14 | 2021-04-15 | Prelude Corporation | Method of selection for treatment of subjects at risk of invasive breast cancer |
KR20210068408A (ko) | 2018-09-28 | 2021-06-09 | 암젠 인크 | 가용성 bcma에 대한 항체 |
SG11202103275YA (en) | 2018-10-11 | 2021-04-29 | Amgen Inc | Downstream processing of bispecific antibody constructs |
JP2022512860A (ja) | 2018-11-06 | 2022-02-07 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | 白血病幹細胞を根絶することによる急性骨髄性白血病の治療のための方法および医薬組成物 |
BR112021012513A2 (pt) | 2019-01-03 | 2021-09-14 | Invetx Inc. | Composições para aumentar a meia-vida de um agente terapêutico em caninos e métodos de uso |
KR102245664B1 (ko) * | 2019-05-16 | 2021-04-27 | 인하대학교 산학협력단 | 에어로졸 증착 공정을 이용한 고상 단결정의 제조 방법 |
MX2021014644A (es) | 2019-06-13 | 2022-04-06 | Amgen Inc | Control de perfusion basado en biomasa automatizado en la fabricacion de productos biologicos. |
CA3152946A1 (en) | 2019-09-10 | 2021-03-18 | Amgen Inc. | Purification method for bispecific antigen-binding polypeptides with enhanced protein l capture dynamic binding capacity |
AU2020381536A1 (en) | 2019-11-13 | 2022-04-21 | Amgen Inc. | Method for reduced aggregate formation in downstream processing of bispecific antigen-binding molecules |
JP2023507083A (ja) * | 2019-12-19 | 2023-02-21 | クイデル コーポレーション | モノクローナル抗体融合物 |
US11918936B2 (en) | 2020-01-17 | 2024-03-05 | Waters Technologies Corporation | Performance and dynamic range for oligonucleotide bioanalysis through reduction of non specific binding |
WO2021150824A1 (en) | 2020-01-22 | 2021-07-29 | Amgen Research (Munich) Gmbh | Combinations of antibody constructs and inhibitors of cytokine release syndrome and uses thereof |
EP3882632A1 (en) | 2020-03-18 | 2021-09-22 | Universite De Bordeaux | Novel ion conducting channel fusion subunits and methods of use thereof |
IL296601A (en) | 2020-03-19 | 2022-11-01 | Amgen Inc | Antibodies against mucin 17 and their uses |
WO2021231464A1 (en) | 2020-05-11 | 2021-11-18 | Invetx Inc. | Compositions for increasing half-life of a therapeutic agent in canines and methods of use |
JP2023527293A (ja) | 2020-05-19 | 2023-06-28 | アムジエン・インコーポレーテツド | Mageb2結合構築物 |
CA3183693A1 (en) | 2020-05-29 | 2021-12-02 | Amgen Inc. | Adverse effects-mitigating administration of a bispecific construct binding to cd33 and cd3 |
WO2022008488A1 (en) | 2020-07-06 | 2022-01-13 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Use of slamf1 as a biomarker in colorectal cancer |
WO2022010652A1 (en) | 2020-07-10 | 2022-01-13 | Invetx Inc. | Compositions for increasing half-life of a therapeutic agent in felines and methods of use |
WO2022013256A1 (en) | 2020-07-15 | 2022-01-20 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Use of cd160 as a biomarker in acute myeloid leukemia |
US20230392182A1 (en) * | 2020-10-30 | 2023-12-07 | Albert Einstein College Of Medicine | Reporter mycobacteriophage, assays and methods comprising the reporter mycobacteriophage |
BR112023008629A2 (pt) | 2020-11-06 | 2023-10-03 | Amgen Inc | Construtos de polipeptídeos que se ligam seletivamente a cldn6 e cd3 |
BR112023008670A2 (pt) | 2020-11-06 | 2024-02-06 | Amgen Inc | Construtos polipeptídicos ligados à cd3 |
AU2021374839A1 (en) | 2020-11-06 | 2023-06-08 | Amgen Inc. | Multitargeting bispecific antigen-binding molecules of increased selectivity |
IL301926A (en) | 2020-11-06 | 2023-06-01 | Amgen Inc | Antigen binding domain with reduced cleavage rate |
EP4281774A2 (en) | 2021-01-20 | 2023-11-29 | Nautilus Subsidiary, Inc. | Methods for biomolecule quantitation |
CN117321200A (zh) | 2021-03-22 | 2023-12-29 | 朱诺治疗学股份有限公司 | 评估病毒载体颗粒效力的方法 |
AR125290A1 (es) | 2021-04-02 | 2023-07-05 | Amgen Inc | Construcciones de unión a mageb2 |
IL307672A (en) | 2021-05-06 | 2023-12-01 | Amgen Res Munich Gmbh | CD20 and CD22 targeting antigen-binding molecules for use in proliferative diseases |
CN113552102B (zh) * | 2021-07-16 | 2022-05-17 | 上海交通大学 | 一种基于荧光相关光谱检测有机溶剂诱导蛋白聚集的药物筛选方法 |
WO2023218027A1 (en) | 2022-05-12 | 2023-11-16 | Amgen Research (Munich) Gmbh | Multichain multitargeting bispecific antigen-binding molecules of increased selectivity |
WO2024059675A2 (en) | 2022-09-14 | 2024-03-21 | Amgen Inc. | Bispecific molecule stabilizing composition |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5292658A (en) * | 1989-12-29 | 1994-03-08 | University Of Georgia Research Foundation, Inc. Boyd Graduate Studies Research Center | Cloning and expressions of Renilla luciferase |
JPH06504903A (ja) * | 1991-03-11 | 1994-06-09 | ザ・ユニバーシテイ・オブ・ジヨージア・リサーチ・フアウンデーシヨン・インコーポレーテツド | レニラ(renilla)ルシフェラーゼのクローニング及び発現 |
WO1997029319A2 (en) * | 1996-02-06 | 1997-08-14 | Bryan Bruce J | Bioluminescent novelty items |
Family Cites Families (144)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2541851A (en) | 1944-12-23 | 1951-02-13 | Gen Electric | Process for making puttylike elastic plastic, siloxane derivative composition containing zinc hydroxide |
US3384498A (en) | 1967-01-04 | 1968-05-21 | Oil Ct Res Inc | Plastic modeling composition |
US3511612A (en) | 1967-03-20 | 1970-05-12 | American Cyanamid Co | Chemiluminescent systems |
US3565815A (en) | 1967-12-28 | 1971-02-23 | Ind Mfg Co Inc | Phosphor containing plastic polystyrene |
US3584211A (en) | 1968-10-07 | 1971-06-08 | American Cyanamid Co | Chemiluminescent liquid dispensing or display container |
US3634280A (en) | 1968-12-31 | 1972-01-11 | Peter Hodgson | Glowing bouncing putty |
GB1317183A (en) | 1969-05-30 | 1973-05-16 | Unilever Ltd | Cleansing compositions |
US3649029A (en) | 1969-07-09 | 1972-03-14 | Eugene N Worrell | Golf practice apparatus |
US3661790A (en) | 1969-10-20 | 1972-05-09 | Arnold Clark | Glowing bouncing putty |
US3727236A (en) | 1971-06-15 | 1973-04-17 | K Lloyd | Disposable apron |
CH594444A5 (US06436682-20020820-C00006.png) | 1972-12-04 | 1978-01-13 | Gerd Birrenbach | |
US3873485A (en) | 1974-04-01 | 1975-03-25 | A Thomas Fichera | Moldable aqueous plastic mass of polyethylene oxide fumed silica and polyglycol |
US4313843A (en) | 1974-04-26 | 1982-02-02 | American Cyanamid Company | Superior oxalate ester chemical lighting system |
FR2292595A1 (fr) | 1974-11-28 | 1976-06-25 | Jourdain Jean | Fontaine a mousse |
DK143689C (da) | 1975-03-20 | 1982-03-15 | J Kreuter | Fremgangsmaade til fremstilling af en adsorberet vaccine |
US4324683A (en) | 1975-08-20 | 1982-04-13 | Damon Corporation | Encapsulation of labile biological material |
DE2621974A1 (de) | 1976-05-18 | 1977-11-24 | Max Planck Gesellschaft | Verfahren zur herstellung eines zur kovalenten bindung mit biologisch aktivem material befaehigten traegermaterials |
US4175183A (en) | 1977-03-01 | 1979-11-20 | Development Finance Corporation Of New Zealand | Hydroxyalkylated cross-linked regenerated cellulose and method of preparation thereof |
SE7811630L (sv) | 1977-11-17 | 1979-05-18 | Welsh Nat School Med | Metod for uppteckt eller mengdbestemning av substanser med anvendning av merkningsteknik |
US4229790A (en) | 1978-10-16 | 1980-10-21 | Denelcor, Inc. | Concurrent task and instruction processor and method |
EP0025350A3 (en) | 1979-09-05 | 1981-06-10 | Dynatech Ag | Apparatus for detecting luminescent reactions |
US4282287A (en) | 1980-01-24 | 1981-08-04 | Giese Roger W | Biochemical avidin-biotin multiple-layer system |
US4882165A (en) | 1981-11-09 | 1989-11-21 | The Regents Of The University Of California | Light sensitive liposomes |
US4870009A (en) | 1982-11-22 | 1989-09-26 | The Salk Institute For Biological Studies | Method of obtaining gene product through the generation of transgenic animals |
US4581335A (en) | 1982-12-01 | 1986-04-08 | Texas A&M University System | Process for producing a cloned luciferase-synthesizing microorganism |
US4528180A (en) | 1983-03-01 | 1985-07-09 | Schaeffer Hans A | Dental preparation, article and method for storage and delivery thereof |
GB8314523D0 (en) | 1983-05-25 | 1983-06-29 | Lowe C R | Diagnostic device |
US4745051A (en) | 1983-05-27 | 1988-05-17 | The Texas A&M University System | Method for producing a recombinant baculovirus expression vector |
US4542102A (en) | 1983-07-05 | 1985-09-17 | Molecular Diagnostics, Inc. | Coupling of nucleic acids to solid support by photochemical methods |
DE8335529U1 (de) | 1983-12-10 | 1984-03-08 | Upat Gmbh & Co, 7830 Emmendingen | Spritz-kartusche |
US4952496A (en) | 1984-03-30 | 1990-08-28 | Associated Universities, Inc. | Cloning and expression of the gene for bacteriophage T7 RNA polymerase |
US4789633A (en) | 1984-04-19 | 1988-12-06 | University Of Tennessee Research Corporation | Fused liposome and acid induced method for liposome fusion |
US4563726A (en) | 1984-08-20 | 1986-01-07 | Newcomb Nelson F | Illuminated chemiluminescent drinking mug |
US4534317A (en) | 1984-08-30 | 1985-08-13 | Cape Cod Research | Procedures for monitoring fish food consumption |
FR2570703B1 (fr) | 1984-09-26 | 1988-07-08 | Commissariat Energie Atomique | Complexes macropolycycliques de terres rares et application a titre de marqueurs fluorescents |
US4767206A (en) | 1984-12-24 | 1988-08-30 | Flow Cytometry Standards Corporation | Calibration method for flow cytometry using fluorescent microbeads and synthesis thereof |
US4774189A (en) | 1984-12-24 | 1988-09-27 | Flow Cytometry Standards Corp. | Fluorescent calibration microbeads simulating stained cells |
NZ214563A (en) | 1984-12-31 | 1991-05-28 | Univ Georgia | Production of apoaeqorin using recombinant dna |
US5422266A (en) | 1984-12-31 | 1995-06-06 | University Of Georgia Research Foundation, Inc. | Recombinant DNA vectors capable of expressing apoaequorin |
DE3500180A1 (de) | 1985-01-04 | 1986-07-10 | Ernst Prof. Dr. 7400 Tübingen Bayer | Pfropfcopolymerisate aus vernetzten polymeren und polyoxyethylen, verfahren zu ihrer herstellung und ihre verwendung |
US4681870A (en) | 1985-01-11 | 1987-07-21 | Imre Corporation | Protein A-silica immunoadsorbent and process for its production |
US4772453A (en) | 1985-03-01 | 1988-09-20 | Lisenbee Wayne F | Luminiscence measurement arrangement |
US5096807A (en) | 1985-03-06 | 1992-03-17 | Murex Corporation | Imaging immunoassay detection system with background compensation and its use |
US4921757A (en) | 1985-04-26 | 1990-05-01 | Massachusetts Institute Of Technology | System for delayed and pulsed release of biologically active substances |
US4861709A (en) | 1985-05-31 | 1989-08-29 | Technicon Research A.G. | Detection and/or identification of microorganisms in a test sample using bioluminescence or other exogenous genetically-introduced marker |
US4853327A (en) | 1985-07-10 | 1989-08-01 | Molecular Diagnostics, Inc. | Enhanced phthalazinedione chemiluminescence |
US4950588A (en) | 1985-07-10 | 1990-08-21 | Molecular Diagnostics, Inc. | Prolonged enhanced chemiluminescence |
US5279943A (en) | 1985-08-02 | 1994-01-18 | Compagnie Oris Industrie | Homogeneous process for the detection and/or determination by luminescence of an analyte in a medium in which it may be present |
DE3537877A1 (de) | 1985-10-24 | 1987-04-30 | Geiger Reinhard | Luciferin-derivate und immunoassays unter einsatz derartiger luciferin-derivate |
US4714682A (en) | 1985-12-11 | 1987-12-22 | Flow Cytometry Standards Corporation | Fluorescent calibration microbeads simulating stained cells |
JPS62171695A (ja) | 1985-12-14 | 1987-07-28 | Chisso Corp | 発光蛋白アクアリン遺伝子を用いるアクアリン活性を有する蛋白質の製造法 |
FR2597725B1 (fr) | 1986-04-29 | 1990-06-15 | Noirot Extraits | Procede pour l'obtention d'un effet de phosphorescence et produits obtenus selon ce procede. |
JPS62261942A (ja) | 1986-05-08 | 1987-11-14 | Chisso Corp | 金属の検出方法 |
US4777128A (en) | 1986-05-27 | 1988-10-11 | Ethigen Corporation | Fluorescence immunoassay involving energy transfer between two fluorophores |
US4717158A (en) | 1986-06-26 | 1988-01-05 | Pennisi Anthony J | Game footbag |
US5004565A (en) | 1986-07-17 | 1991-04-02 | The Board Of Governors Of Wayne State University | Method and compositions providing enhanced chemiluminescence from 1,2-dioxetanes |
US5221623A (en) | 1986-07-22 | 1993-06-22 | Boyce Thompson Institute For Plant Research, Inc. | Use of bacterial luciferase structural genes for cloning and monitoring gene expression in microorganisms and for tagging and identification of genetically engineered organisms |
US4867908A (en) | 1986-08-29 | 1989-09-19 | Becton, Dickinson And Company | Method and materials for calibrating flow cytometers and other analysis instruments |
US5093240A (en) | 1986-10-15 | 1992-03-03 | Chisso Corporation | Variant aequorin genes and process for producing variant aequorin proteins |
US5268463A (en) | 1986-11-11 | 1993-12-07 | Jefferson Richard A | Plant promoter α-glucuronidase gene construct |
US4762881A (en) | 1987-01-09 | 1988-08-09 | E. I. Du Pont De Nemours And Company | Photoreactive benzoylphenylalanines and related peptides |
US5128256A (en) | 1987-01-12 | 1992-07-07 | Stratagene | DNA cloning vectors with in vivo excisable plasmids |
US4765510A (en) | 1987-04-07 | 1988-08-23 | Rende Vincent N | Multiple color fluid dispensing gun |
US4781647A (en) | 1987-05-04 | 1988-11-01 | Hasbro, Inc. | Toy doll construction with phosphorescent hair fibers |
US4891043A (en) | 1987-05-28 | 1990-01-02 | Board Of Trustees Of The University Of Illinois | System for selective release of liposome encapsulated material via laser radiation |
US4735660A (en) | 1987-06-26 | 1988-04-05 | Mattel, Inc. | Cross-linked gel modeling composition |
US4968613A (en) | 1987-07-29 | 1990-11-06 | Kikkoman Corporation | Luciferase gene and novel recombinant DNA as well as a method of producing luciferase |
JPS6447379A (en) | 1987-08-19 | 1989-02-21 | Chisso Corp | Preparation of calcium-dependent oxygenation enzyme |
JP2592623B2 (ja) | 1987-11-18 | 1997-03-19 | チッソ株式会社 | アポエクオリンの製造法 |
US5182202A (en) | 1987-11-30 | 1993-01-26 | Kikkoman Corporation | Purified luciferase from luciola cruciata |
US5162508A (en) | 1987-12-18 | 1992-11-10 | Compagnie Oris Industrie | Rare earth cryptates, processes for their preparation, synthesis intermediates and application as fluorescent tracers |
JPH088864B2 (ja) | 1988-04-12 | 1996-01-31 | キッコーマン株式会社 | ルシフェラーゼ |
EP0387355B1 (en) | 1988-08-09 | 1996-11-06 | Toray Industries, Inc. | Process for preparing luciferase by recombinant expression of a luciferase-coding gene |
US5604123A (en) | 1988-08-09 | 1997-02-18 | Toray Industries, Inc. | Luciferase, gene encoding the same and production process of the same |
US4924358A (en) | 1988-09-12 | 1990-05-08 | Inventech Licensing Co. | Safety-sparkler wand w/chemiluminescent or electric-light illumination |
US5196524A (en) | 1989-01-06 | 1993-03-23 | Eli Lilly And Company | Fusion reporter gene for bacterial luciferase |
JPH02234698A (ja) | 1989-03-08 | 1990-09-17 | Toyobo Co Ltd | 細菌ルシフェラーゼ系によるdnaプローブの検出法 |
US5360726A (en) | 1989-09-12 | 1994-11-01 | Board Of Trustees Operating Michigan State University | Polypeptides enabling sorting of proteins to vacuoles in plants |
US5288623A (en) | 1989-10-26 | 1994-02-22 | Chisso Corporation | Process for secretory production of a calcium-binding protein |
DE3935974A1 (de) | 1989-10-28 | 1991-05-02 | Mueller Klieser Wolfgang Prof | Verfahren zur bestimmung von metaboliten in gewebeproben, enzymcocktail und vorrichtung zu dessen durchfuehrung |
US4963117A (en) | 1989-10-30 | 1990-10-16 | Gualdoni Kevin G | Selectively illuminated toy ball |
JP2626738B2 (ja) | 1990-03-13 | 1997-07-02 | 三共株式会社 | 化学発光検出装置 |
US5219737A (en) | 1990-03-27 | 1993-06-15 | Kikkoman Corporation | Mutant luciferase of a firefly, mutant luciferase genes, recombinant dnas containing the genes and a method of producing mutant luciferase |
US5433896A (en) | 1994-05-20 | 1995-07-18 | Molecular Probes, Inc. | Dibenzopyrrometheneboron difluoride dyes |
US5189029A (en) | 1990-04-23 | 1993-02-23 | Bo-Dekk Ventures, Ltd. | Indacene compounds and methods for using the same |
US5196318A (en) | 1990-06-26 | 1993-03-23 | The Texas A&M University System | Precisely regulated expression of deleterious genes |
EP0537270B1 (en) | 1990-07-02 | 1998-09-09 | The Regents Of The University Of California | Detection of analytes using fluorescent energy transfer |
US5374534A (en) | 1990-07-19 | 1994-12-20 | Charm Sciences, Inc. | Method of preparing D-luciferin derivatives |
BE1005073A7 (fr) | 1990-08-30 | 1993-04-13 | Collet Marcel Georges | Procede d'illumination des liquides et dispositifs appropries a un tel procede. |
JPH06501099A (ja) | 1990-09-11 | 1994-01-27 | ヴォアヒーズ・テクノロジース・インコーポレーテッド | 被覆された毛管 |
US5169784A (en) | 1990-09-17 | 1992-12-08 | The Texas A & M University System | Baculovirus dual promoter expression vector |
US5266317A (en) | 1990-10-04 | 1993-11-30 | University Of Georgia Research Foundation, Inc. | Insect-specific paralytic neurotoxin genes for use in biological insect control: methods and compositions |
JP2856339B2 (ja) | 1991-02-21 | 1999-02-10 | キッコーマン株式会社 | 酵素免疫測定法 |
JP2515218B2 (ja) | 1991-04-02 | 1996-07-10 | アルカテル・カーブル | 半導体遮蔽用材料 |
US5229285A (en) | 1991-06-27 | 1993-07-20 | Kikkoman Corporation | Thermostable luciferase of firefly, thermostable luciferase gene of firefly, novel recombinant dna, and process for the preparation of thermostable luciferase of firefly |
US5158349A (en) | 1991-07-03 | 1992-10-27 | Lexington & Associates, Inc. | Multi-color chemical lighting device |
US5383100A (en) | 1991-08-02 | 1995-01-17 | Kikos; J. Peter | Multi-channel tubular display package |
US5243041A (en) | 1991-08-22 | 1993-09-07 | Fernandez Pol Jose A | DNA vector with isolated CDNA gene encoding metallopanstimulin |
US5277913A (en) | 1991-09-09 | 1994-01-11 | Thompson David H | Liposomal delivery system with photoactivatable triggered release |
US5222797A (en) | 1991-10-31 | 1993-06-29 | Lexington & Associates | Multi-chamber chemiluminescent optical display device |
US5605662A (en) | 1993-11-01 | 1997-02-25 | Nanogen, Inc. | Active programmable electronic devices for molecular biological analysis and diagnostics |
US5632957A (en) | 1993-11-01 | 1997-05-27 | Nanogen | Molecular biological diagnostic systems including electrodes |
US5413098A (en) | 1991-12-24 | 1995-05-09 | Sextant Medical Corporation | Path constrained spectrophotometer and method for determination of spatial distribution of light or other radiation scattering and absorbing substances in a radiation scattering medium |
DE4210759A1 (de) | 1992-04-01 | 1993-10-07 | Boehringer Mannheim Gmbh | Substituierte Thiazolin-Dioxetan-Substrate, Verfahren zur Herstellung und Verwendung |
US5310421A (en) | 1992-02-07 | 1994-05-10 | Mattel, Inc. | Play material |
ATE136925T1 (de) | 1992-02-14 | 1996-05-15 | Amersham Int Plc | Fluoreszente verbindungen |
US5337745A (en) | 1992-03-10 | 1994-08-16 | Benaron David A | Device and method for in vivo qualitative or quantative measurement of blood chromophore concentration using blood pulse spectrophotometry |
US5171081A (en) | 1992-05-29 | 1992-12-15 | Pita Joe W | Chemiluminescent reactive vessel |
AU669384B2 (en) | 1992-07-09 | 1996-06-06 | Pioneer Hi-Bred International, Inc. | Maize pollen-specific polygalacturonase gene |
US5323492A (en) | 1992-08-10 | 1994-06-28 | Demars Robert A | Illuminated article of wearing apparel with afterglow |
US5360728A (en) | 1992-12-01 | 1994-11-01 | Woods Hole Oceanographic Institution (W.H.O.I.) | Modified apoaequorin having increased bioluminescent activity |
US5405958A (en) | 1992-12-21 | 1995-04-11 | Transitions Optical, Inc. | Photochromic spiro(indoline)naphthoxazine compounds |
EP0683822B1 (en) | 1993-02-12 | 2002-05-02 | Sealite Sciences, Inc. | Preparation of photoprotein conjugates and methods of use thereof |
US5366881A (en) | 1993-02-23 | 1994-11-22 | The United States Of America As Represented By The Secretary Of The Navy | Polymerizable lipids for preparing vesicles that controllably release an encapsulant |
US5496934A (en) | 1993-04-14 | 1996-03-05 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Nucleic acids encoding a cellulose binding domain |
US5364797A (en) | 1993-05-20 | 1994-11-15 | Mobil Oil Corp. | Sensor device containing mesoporous crystalline material |
US5464758A (en) | 1993-06-14 | 1995-11-07 | Gossen; Manfred | Tight control of gene expression in eucaryotic cells by tetracycline-responsive promoters |
US5451347A (en) | 1993-06-24 | 1995-09-19 | Lumigen, Inc. | Methods and compositions providing enhanced chemiluminescence from chemiluminescent compounds using dicationic surfactants |
JPH0779783A (ja) | 1993-06-28 | 1995-03-28 | Chisso Corp | ビブリオ フィシエリ由来のフラビン還元酵素遺伝子 |
US5424216A (en) | 1993-08-16 | 1995-06-13 | Jasco Corporation | No radical measuring method and apparatus |
US5362865A (en) | 1993-09-02 | 1994-11-08 | Monsanto Company | Enhanced expression in plants using non-translated leader sequences |
US5491084A (en) | 1993-09-10 | 1996-02-13 | The Trustees Of Columbia University In The City Of New York | Uses of green-fluorescent protein |
US5415151A (en) | 1993-09-20 | 1995-05-16 | Jcf Research Associates, Inc. | Phosphor-containing projectile and launcher therefor |
US5405905A (en) | 1993-11-26 | 1995-04-11 | Hy-Tec Enterprises | Artificial soil and soil-forming composition |
AU698424C (en) * | 1994-01-03 | 2002-10-10 | Promega Corporation | Mutant luciferases |
FI95484C (fi) | 1994-01-17 | 1996-02-12 | Marko Virta | Menetelmä näytteessä olevan metallin määrittämiseksi |
WO1995021191A1 (en) | 1994-02-04 | 1995-08-10 | William Ward | Bioluminescent indicator based upon the expression of a gene for a modified green-fluorescent protein |
GB9501170D0 (en) * | 1994-03-23 | 1995-03-08 | Secr Defence | Luciferases |
GB2288232A (en) | 1994-04-06 | 1995-10-11 | Brf International | Photosensitive derivatives of ATP as assay control standards |
US5413332A (en) | 1994-05-26 | 1995-05-09 | Amber Forrest, Inc. | Eggball |
JP3030678B2 (ja) | 1994-06-17 | 2000-04-10 | 崇 近藤 | 自動車ドアの補助開閉機構 |
US5625048A (en) | 1994-11-10 | 1997-04-29 | The Regents Of The University Of California | Modified green fluorescent proteins |
US5777079A (en) | 1994-11-10 | 1998-07-07 | The Regents Of The University Of California | Modified green fluorescent proteins |
JPH08136546A (ja) | 1994-11-15 | 1996-05-31 | Bio Sensor Kenkyusho:Kk | 物質分析法 |
US5624711A (en) | 1995-04-27 | 1997-04-29 | Affymax Technologies, N.V. | Derivatization of solid supports and methods for oligomer synthesis |
AU4482996A (en) * | 1995-09-22 | 1997-04-09 | Novo Nordisk A/S | Novel variants of green fluorescent protein, gfp |
US5730321A (en) | 1995-12-13 | 1998-03-24 | Mcallister; Todd | Glow-in-the-dark water emitters |
US5874304A (en) | 1996-01-18 | 1999-02-23 | University Of Florida Research Foundation, Inc. | Humanized green fluorescent protein genes and methods |
US6803188B1 (en) * | 1996-01-31 | 2004-10-12 | The Regents Of The University Of California | Tandem fluorescent protein constructs |
US5804387A (en) | 1996-02-01 | 1998-09-08 | The Board Of Trustees Of The Leland Stanford Junior University | FACS-optimized mutants of the green fluorescent protein (GFP) |
US5912137A (en) | 1996-07-16 | 1999-06-15 | The Regents Of The University Of California | Assays for protein kinases using fluorescent |
US5976796A (en) * | 1996-10-04 | 1999-11-02 | Loma Linda University | Construction and expression of renilla luciferase and green fluorescent protein fusion genes |
ATE354089T1 (de) * | 1997-04-07 | 2007-03-15 | Fisher Bioimage Aps | Ein verfahren zum screenen von substanzen hinsichtlich ihres effekts auf camp spiegel basierend auf intrazellulärer translokation von pka |
US5891646A (en) | 1997-06-05 | 1999-04-06 | Duke University | Methods of assaying receptor activity and constructs useful in such methods |
-
1999
- 1999-03-26 US US09/277,716 patent/US6232107B1/en not_active Expired - Lifetime
- 1999-03-26 DE DE69938293T patent/DE69938293T2/de not_active Expired - Lifetime
- 1999-03-26 EP EP99914203A patent/EP1064360B1/en not_active Expired - Lifetime
- 1999-03-26 JP JP2000537980A patent/JP2002507410A/ja active Pending
- 1999-03-26 CA CA2324648A patent/CA2324648C/en not_active Expired - Fee Related
- 1999-03-26 AT AT99914203T patent/ATE388224T1/de not_active IP Right Cessation
- 1999-03-26 WO PCT/US1999/006698 patent/WO1999049019A2/en active IP Right Grant
- 1999-03-26 AU AU32103/99A patent/AU765703B2/en not_active Ceased
-
2000
- 2000-06-30 US US09/609,161 patent/US6436682B1/en not_active Expired - Lifetime
-
2009
- 2009-01-05 JP JP2009000303A patent/JP4923068B2/ja not_active Expired - Fee Related
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5292658A (en) * | 1989-12-29 | 1994-03-08 | University Of Georgia Research Foundation, Inc. Boyd Graduate Studies Research Center | Cloning and expressions of Renilla luciferase |
US5418155A (en) * | 1989-12-29 | 1995-05-23 | University Of Georgia Research Foundation, Inc. | Isolated Renilla luciferase and method of use thereof |
JPH06504903A (ja) * | 1991-03-11 | 1994-06-09 | ザ・ユニバーシテイ・オブ・ジヨージア・リサーチ・フアウンデーシヨン・インコーポレーテツド | レニラ(renilla)ルシフェラーゼのクローニング及び発現 |
WO1997029319A2 (en) * | 1996-02-06 | 1997-08-14 | Bryan Bruce J | Bioluminescent novelty items |
Non-Patent Citations (1)
Title |
---|
PROC.NATL.ACAD.SCI.USA.,VOL.88,NO.10(1991)P.4438-4442, JPN6008032375, ISSN: 0001076339 * |
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WO2006061906A1 (ja) * | 2004-12-09 | 2006-06-15 | Nec Soft, Ltd. | 新規なルシフェラーゼをコードする遺伝子 |
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Also Published As
Publication number | Publication date |
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DE69938293D1 (de) | 2008-04-17 |
CA2324648A1 (en) | 1999-09-30 |
JP4923068B2 (ja) | 2012-04-25 |
ATE388224T1 (de) | 2008-03-15 |
DE69938293T2 (de) | 2009-03-12 |
US6436682B1 (en) | 2002-08-20 |
CA2324648C (en) | 2013-02-26 |
WO1999049019A3 (en) | 2000-06-29 |
EP1064360B1 (en) | 2008-03-05 |
EP1064360A2 (en) | 2001-01-03 |
JP2009148270A (ja) | 2009-07-09 |
WO1999049019A2 (en) | 1999-09-30 |
US6232107B1 (en) | 2001-05-15 |
WO1999049019A8 (en) | 2000-09-08 |
AU3210399A (en) | 1999-10-18 |
AU765703B2 (en) | 2003-09-25 |
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