JP2002500676A5 - - Google Patents

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Publication number
JP2002500676A5
JP2002500676A5 JP1999500987A JP50098799A JP2002500676A5 JP 2002500676 A5 JP2002500676 A5 JP 2002500676A5 JP 1999500987 A JP1999500987 A JP 1999500987A JP 50098799 A JP50098799 A JP 50098799A JP 2002500676 A5 JP2002500676 A5 JP 2002500676A5
Authority
JP
Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
JP1999500987A
Other languages
English (en)
Japanese (ja)
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JP2002500676A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US1998/011036 external-priority patent/WO1998054158A1/en
Publication of JP2002500676A publication Critical patent/JP2002500676A/ja
Publication of JP2002500676A5 publication Critical patent/JP2002500676A5/ja
Ceased legal-status Critical Current

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JP50098799A 1997-05-28 1998-05-28 血小板由来成長因子及び/又はp56▲上lck▼チロシンキナーゼを阻害するキノリン及びキノキサリン化合物 Ceased JP2002500676A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US86445597A 1997-05-28 1997-05-28
US97261497A 1997-11-18 1997-11-18
US08/972,614 1997-11-18
US08/864,455 1997-11-18
PCT/US1998/011036 WO1998054158A1 (en) 1997-05-28 1998-05-28 QUINOLINE AND QUINOXALINE COMPOUNDS WHICH INHIBIT PLATELET-DERIVED GROWTH FACTOR AND/OR p56lck TYROSINE KINASES

Publications (2)

Publication Number Publication Date
JP2002500676A JP2002500676A (ja) 2002-01-08
JP2002500676A5 true JP2002500676A5 (enExample) 2005-12-22

Family

ID=27127839

Family Applications (3)

Application Number Title Priority Date Filing Date
JP50096599A Ceased JP2002500675A (ja) 1997-05-28 1998-05-28 血小板由来成長因子及び/又はp56▲上lck▼チロシンキナーゼを阻害するキノリン及びキノキサリン化合物
JP50098799A Ceased JP2002500676A (ja) 1997-05-28 1998-05-28 血小板由来成長因子及び/又はp56▲上lck▼チロシンキナーゼを阻害するキノリン及びキノキサリン化合物
JP50096499A Ceased JP2002513417A (ja) 1997-05-28 1998-05-28 血小板由来成長因子及び/又はP56▲上lck▼チロシンキナーゼを阻害するキノリン及びキノキサリン化合物

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP50096599A Ceased JP2002500675A (ja) 1997-05-28 1998-05-28 血小板由来成長因子及び/又はp56▲上lck▼チロシンキナーゼを阻害するキノリン及びキノキサリン化合物

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP50096499A Ceased JP2002513417A (ja) 1997-05-28 1998-05-28 血小板由来成長因子及び/又はP56▲上lck▼チロシンキナーゼを阻害するキノリン及びキノキサリン化合物

Country Status (25)

Country Link
EP (3) EP1001946B1 (enExample)
JP (3) JP2002500675A (enExample)
KR (2) KR100440756B1 (enExample)
CN (3) CN1280572A (enExample)
AP (3) AP1554A (enExample)
AT (3) ATE493389T1 (enExample)
AU (3) AU742739B2 (enExample)
BG (3) BG64444B1 (enExample)
BR (3) BR9809501A (enExample)
CA (3) CA2291750A1 (enExample)
CZ (3) CZ298521B6 (enExample)
DE (3) DE69828607T2 (enExample)
DK (1) DK0991628T3 (enExample)
EA (4) EA004103B1 (enExample)
ES (1) ES2235331T3 (enExample)
HU (2) HUP0002084A3 (enExample)
IL (3) IL133009A0 (enExample)
NO (3) NO323720B1 (enExample)
OA (3) OA11264A (enExample)
PL (3) PL194980B1 (enExample)
PT (1) PT991628E (enExample)
SI (1) SI0991628T1 (enExample)
SK (4) SK158099A3 (enExample)
UA (1) UA57790C2 (enExample)
WO (3) WO1998054158A1 (enExample)

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EP1309596B1 (en) 2000-08-11 2008-02-06 Boehringer Ingelheim Pharmaceuticals Inc. Heterocyclic compounds useful as inhibitors of tyrosine kinases
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CN1930128A (zh) 2004-01-16 2007-03-14 惠氏公司 受体酪氨酸激酶抑制剂的喹啉中间体及其合成
JP2010526823A (ja) 2007-05-10 2010-08-05 グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー Pi3キナーゼ阻害物質としてのキノキサリン誘導体
US9084742B2 (en) 2007-12-12 2015-07-21 Axovant Sciences Ltd. Combinations comprising 3-phenylsulfonyl-8-piperazinyl-1yl-Quinoline
WO2009123714A2 (en) 2008-04-02 2009-10-08 Arena Pharmaceuticals, Inc. Processes for the preparation of pyrazole derivatives useful as modulators of the 5-ht2a serotonin receptor
WO2010062321A1 (en) 2008-10-28 2010-06-03 Arena Pharmaceuticals, Inc. Processes useful for the preparation of 1-[3-(4-bromo-2-methyl-2h-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)-urea and crystalline forms related thereto
EP2241557A1 (de) 2009-04-02 2010-10-20 Æterna Zentaris GmbH Chinoxalin-Derivate und deren Anwendung zur Behandlung gutartiger und bösartiger Tumorerkrankungen
CN102596932A (zh) 2009-09-04 2012-07-18 拜耳医药股份有限公司 作为酪氨酸苏氨酸激酶抑制剂的取代氨基喹喔啉
GB201007286D0 (en) 2010-04-30 2010-06-16 Astex Therapeutics Ltd New compounds
CN101823998B (zh) * 2010-05-05 2015-03-25 江苏利田科技股份有限公司 一种反应器耦合模拟移动床乙氧基喹啉清洁生产工艺
BR112013007907A2 (pt) 2010-10-08 2016-06-14 N30 Pharmaceuticals Inc novos compostos de quinolina substituída como inibidores de s-nitrosoglutationa reductase
GB201020179D0 (en) 2010-11-29 2011-01-12 Astex Therapeutics Ltd New compounds
JP5990187B2 (ja) 2010-12-16 2016-09-07 ニヴァリス・セラピューティクス・インコーポレーテッド S−ニトロソグルタチオン還元酵素阻害薬としての新規な置換二環芳香族化合物
US8754114B2 (en) 2010-12-22 2014-06-17 Incyte Corporation Substituted imidazopyridazines and benzimidazoles as inhibitors of FGFR3
GB201118656D0 (en) 2011-10-28 2011-12-07 Astex Therapeutics Ltd New compounds
GB201118654D0 (en) 2011-10-28 2011-12-07 Astex Therapeutics Ltd New compounds
GB201118652D0 (en) 2011-10-28 2011-12-07 Astex Therapeutics Ltd New compounds
GB201118675D0 (en) 2011-10-28 2011-12-14 Astex Therapeutics Ltd New compounds
US9512126B2 (en) 2012-03-14 2016-12-06 Bayer Intellectual Property Gmbh Substituted imidazopyridazines
EP2841428B1 (en) 2012-04-24 2018-08-22 Vertex Pharmaceuticals Incorporated Dna-pk inhibitors
GB201209613D0 (en) 2012-05-30 2012-07-11 Astex Therapeutics Ltd New compounds
GB201209609D0 (en) 2012-05-30 2012-07-11 Astex Therapeutics Ltd New compounds
PE20190736A1 (es) 2012-06-13 2019-05-23 Incyte Holdings Corp Compuestos triciclicos sustituidos como inhibidores del receptor del factor de crecimiento de fibroblastos (fgfr)
WO2014026125A1 (en) 2012-08-10 2014-02-13 Incyte Corporation Pyrazine derivatives as fgfr inhibitors
US9266892B2 (en) 2012-12-19 2016-02-23 Incyte Holdings Corporation Fused pyrazoles as FGFR inhibitors
WO2014159690A1 (en) 2013-03-12 2014-10-02 Vertex Pharmaceuticals Incorporated Dna-pk inhibitors
KR102269032B1 (ko) 2013-04-19 2021-06-24 인사이트 홀딩스 코포레이션 Fgfr 저해제로서 이환식 헤테로사이클
GB201307577D0 (en) 2013-04-26 2013-06-12 Astex Therapeutics Ltd New compounds
PT3008062T (pt) 2013-06-11 2017-06-07 Bayer Pharma AG Derivados de profármaco de triazolopiridinas substituídas
PL3424920T3 (pl) 2013-10-17 2020-11-16 Vertex Pharmaceuticals Incorporated Kokryształy (S)-N-metylo-8-(1-((2'-metylo-4’,6'-dideutero-[4,5'-bipirymidyn]-6-ylo)amino)propan-2-ylo)chinolino-4-karboksyamidu i ich deuterowane pochodne jako inhibitory DNA-PK
MX370099B (es) 2014-03-26 2019-12-02 Astex Therapeutics Ltd Combinación que comprende un inhibidor de fgfr y un inhibidor de cmet para el tratamiento del cáncer.
KR102479696B1 (ko) 2014-03-26 2022-12-22 아스텍스 테라퓨틱스 리미티드 Fgfr 억제제 및 igf1r 억제제의 조합물
JO3512B1 (ar) 2014-03-26 2020-07-05 Astex Therapeutics Ltd مشتقات كينوكسالين مفيدة كمعدلات لإنزيم fgfr كيناز
US10851105B2 (en) 2014-10-22 2020-12-01 Incyte Corporation Bicyclic heterocycles as FGFR4 inhibitors
JOP20200201A1 (ar) 2015-02-10 2017-06-16 Astex Therapeutics Ltd تركيبات صيدلانية تشتمل على n-(3.5- ثنائي ميثوكسي فينيل)-n'-(1-ميثيل إيثيل)-n-[3-(ميثيل-1h-بيرازول-4-يل) كينوكسالين-6-يل]إيثان-1.2-ثنائي الأمين
MA41551A (fr) 2015-02-20 2017-12-26 Incyte Corp Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4
US9580423B2 (en) 2015-02-20 2017-02-28 Incyte Corporation Bicyclic heterocycles as FGFR4 inhibitors
ES2895769T3 (es) 2015-02-20 2022-02-22 Incyte Corp Heterociclos bicíclicos como inhibidores de FGFR
US10478494B2 (en) 2015-04-03 2019-11-19 Astex Therapeutics Ltd FGFR/PD-1 combination therapy for the treatment of cancer
JP2018516992A (ja) 2015-06-12 2018-06-28 アクソファント サイエンシーズ ゲーエムベーハーAxovant Sciences Gmbh レム睡眠行動障害の予防および処置のために有用なジアリールおよびアリールヘテロアリール尿素誘導体
WO2017011767A2 (en) 2015-07-15 2017-01-19 Axovant Sciences Ltd. Diaryl and arylheteroaryl urea derivatives as modulators of the 5-ht2a serotonin receptor useful for the prophylaxis and treatment of hallucinations associated with a neurodegenerative disease
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KR102691777B1 (ko) 2015-09-23 2024-08-02 얀센 파마슈티카 엔브이 비-헤테로아릴 치환된 1,4-벤조디아제핀 및 암의 치료를 위한 이의 용도
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US11591329B2 (en) 2019-07-09 2023-02-28 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
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