IT1210585B - Composti carbostirilici composizioni che li contengono e procedimenti per la loro preparazione - Google Patents

Composti carbostirilici composizioni che li contengono e procedimenti per la loro preparazione

Info

Publication number
IT1210585B
IT1210585B IT8149588A IT4958881A IT1210585B IT 1210585 B IT1210585 B IT 1210585B IT 8149588 A IT8149588 A IT 8149588A IT 4958881 A IT4958881 A IT 4958881A IT 1210585 B IT1210585 B IT 1210585B
Authority
IT
Italy
Prior art keywords
procedures
preparation
compositions containing
compounds compositions
carbostyryl compounds
Prior art date
Application number
IT8149588A
Other languages
English (en)
Italian (it)
Other versions
IT8149588A0 (it
Inventor
Michiaki Tominaga
Hidenori Hogawa
Yung-Hsiung Yang
Kazuyuki Nakagawa
Original Assignee
Otsuka Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharma Co Ltd filed Critical Otsuka Pharma Co Ltd
Publication of IT8149588A0 publication Critical patent/IT8149588A0/it
Application granted granted Critical
Publication of IT1210585B publication Critical patent/IT1210585B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/40—Nitrogen atoms attached in position 8
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
IT8149588A 1980-10-31 1981-10-29 Composti carbostirilici composizioni che li contengono e procedimenti per la loro preparazione IT1210585B (it)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP55154071A JPS5777676A (en) 1980-10-31 1980-10-31 Carbostyril derivative

Publications (2)

Publication Number Publication Date
IT8149588A0 IT8149588A0 (it) 1981-10-29
IT1210585B true IT1210585B (it) 1989-09-14

Family

ID=15576252

Family Applications (2)

Application Number Title Priority Date Filing Date
IT8149588A IT1210585B (it) 1980-10-31 1981-10-29 Composti carbostirilici composizioni che li contengono e procedimenti per la loro preparazione
IT8547867A IT1226479B (it) 1980-10-31 1985-03-26 Composti di acido carbossilico utili come prodotti intermedi per la preparazione di composti carbostirilici

Family Applications After (1)

Application Number Title Priority Date Filing Date
IT8547867A IT1226479B (it) 1980-10-31 1985-03-26 Composti di acido carbossilico utili come prodotti intermedi per la preparazione di composti carbostirilici

Country Status (24)

Country Link
US (1) US4415572A (en, 2012)
JP (1) JPS5777676A (en, 2012)
KR (1) KR860001944B1 (en, 2012)
AR (2) AR242563A1 (en, 2012)
AT (1) AT381701B (en, 2012)
AU (1) AU524419B2 (en, 2012)
BE (1) BE890942A (en, 2012)
CA (1) CA1209575A (en, 2012)
CH (2) CH656616A5 (en, 2012)
DE (2) DE3153260C2 (en, 2012)
DK (1) DK155665C (en, 2012)
ES (3) ES8306743A1 (en, 2012)
FI (1) FI77450C (en, 2012)
FR (2) FR2493320B1 (en, 2012)
GB (1) GB2086896B (en, 2012)
IT (2) IT1210585B (en, 2012)
MX (1) MX8481A (en, 2012)
NL (2) NL194205C (en, 2012)
NO (1) NO158099C (en, 2012)
PH (1) PH17962A (en, 2012)
PT (1) PT73910B (en, 2012)
SE (2) SE448877B (en, 2012)
SU (1) SU1426452A3 (en, 2012)
ZA (1) ZA817515B (en, 2012)

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US4760064A (en) * 1984-12-18 1988-07-26 Otsuka Pharmaceutical Co., Ltd. Carbostyril compounds, compositions containing same and processes for preparing same
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US5166160A (en) * 1986-12-23 1992-11-24 Burroughs Wellcome Co. Quinoline compound
GB8630702D0 (en) * 1986-12-23 1987-02-04 Wellcome Found Quinoline compound
JPS63225357A (ja) * 1987-03-12 1988-09-20 Otsuka Pharmaceut Co Ltd カルボスチリル誘導体
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JPH0733664A (ja) * 1993-07-26 1995-02-03 Otsuka Pharmaceut Co Ltd 平滑筋細胞増殖抑制剤
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US5684007A (en) * 1996-09-05 1997-11-04 Otsuka Pharmaceutical Co., Ltd. Methods for inhibiting cardiac fibroblast growth and cardiac fibrosis
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Also Published As

Publication number Publication date
NL8104923A (nl) 1982-05-17
FI77450B (fi) 1988-11-30
DK155665C (da) 1989-09-04
SE8106430L (sv) 1982-05-01
IT8149588A0 (it) 1981-10-29
PT73910B (en) 1983-04-18
ATA460281A (de) 1986-04-15
NO158099B (no) 1988-04-05
DE3153260A1 (en, 2012) 1985-05-15
DE3153260C2 (en, 2012) 1989-05-24
ES507198A0 (es) 1983-06-16
SE8406209D0 (sv) 1984-12-06
NO813678L (no) 1982-05-03
FI813408L (fi) 1982-05-01
SE8406209L (sv) 1984-12-06
AR242563A1 (es) 1993-04-30
AT381701B (de) 1986-11-25
ES520637A0 (es) 1984-04-16
NL194205C (nl) 2001-09-04
PH17962A (en) 1985-02-20
CH650782A5 (de) 1985-08-15
NL8403096A (nl) 1985-02-01
FI77450C (fi) 1989-03-10
DK155665B (da) 1989-05-01
AU524419B2 (en) 1982-09-16
BE890942A (fr) 1982-02-15
FR2493320B1 (fr) 1985-08-23
ES520638A0 (es) 1984-04-16
KR830007607A (ko) 1983-11-04
NO158099C (no) 1988-07-13
DE3142982A1 (de) 1982-06-24
JPS5777676A (en) 1982-05-15
GB2086896B (en) 1984-10-10
IT1226479B (it) 1991-01-16
JPH0143747B2 (en, 2012) 1989-09-22
ZA817515B (en) 1982-10-27
SE448877B (sv) 1987-03-23
SU1426452A3 (ru) 1988-09-23
KR860001944B1 (ko) 1986-11-01
SE466655B (sv) 1992-03-16
CH656616A5 (de) 1986-07-15
CA1209575A (en) 1986-08-12
AR242375A1 (es) 1993-03-31
US4415572A (en) 1983-11-15
ES8403885A1 (es) 1984-04-16
FR2552760A1 (fr) 1985-04-05
ES8306743A1 (es) 1983-06-16
PT73910A (en) 1981-11-01
MX8481A (es) 1994-02-28
IT8547867A0 (it) 1985-03-26
GB2086896A (en) 1982-05-19
DK480381A (da) 1982-05-01
DE3142982C2 (de) 1985-12-19
ES8403886A1 (es) 1984-04-16
AU7699681A (en) 1982-05-06
FR2493320A1 (fr) 1982-05-07
FR2552760B1 (fr) 1988-08-05
NL194205B (nl) 2001-05-01

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