IN2015KN00262A - - Google Patents
Info
- Publication number
- IN2015KN00262A IN2015KN00262A IN262KON2015A IN2015KN00262A IN 2015KN00262 A IN2015KN00262 A IN 2015KN00262A IN 262KON2015 A IN262KON2015 A IN 262KON2015A IN 2015KN00262 A IN2015KN00262 A IN 2015KN00262A
- Authority
- IN
- India
- Prior art keywords
- forms
- isoquinoline
- phenoxy
- carbonyl
- hydroxy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Vascular Medicine (AREA)
- Dermatology (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Communicable Diseases (AREA)
- Psychiatry (AREA)
- Pulmonology (AREA)
- Ophthalmology & Optometry (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Rheumatology (AREA)
- AIDS & HIV (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261672191P | 2012-07-16 | 2012-07-16 | |
US201361768297P | 2013-02-22 | 2013-02-22 | |
US201361832566P | 2013-06-07 | 2013-06-07 | |
PCT/US2013/050539 WO2014014835A2 (en) | 2012-07-16 | 2013-07-15 | Crystalline forms of a prolyl hydroxylase inhibitor |
Publications (1)
Publication Number | Publication Date |
---|---|
IN2015KN00262A true IN2015KN00262A (sr) | 2015-06-12 |
Family
ID=48857025
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IN262KON2015 IN2015KN00262A (sr) | 2012-07-16 | 2013-07-15 |
Country Status (27)
Country | Link |
---|---|
US (5) | US9115085B2 (sr) |
EP (3) | EP3470397B1 (sr) |
JP (2) | JP6491093B2 (sr) |
KR (4) | KR20210130849A (sr) |
CN (9) | CN103539735B (sr) |
AU (1) | AU2013290438C1 (sr) |
BR (1) | BR112015001101A2 (sr) |
CA (1) | CA2879242C (sr) |
CY (2) | CY1120805T1 (sr) |
DK (2) | DK2872488T3 (sr) |
ES (2) | ES2905898T3 (sr) |
FR (1) | FR22C1030I1 (sr) |
HK (1) | HK1243409A1 (sr) |
HR (2) | HRP20220182T1 (sr) |
HU (2) | HUE041458T2 (sr) |
IL (1) | IL236626B (sr) |
IN (1) | IN2015KN00262A (sr) |
LT (3) | LT3470397T (sr) |
MX (1) | MX355428B (sr) |
MY (1) | MY182428A (sr) |
NZ (1) | NZ704662A (sr) |
PL (2) | PL2872488T3 (sr) |
PT (2) | PT2872488T (sr) |
RS (2) | RS63122B1 (sr) |
SG (3) | SG10202111314YA (sr) |
SI (2) | SI2872488T1 (sr) |
WO (1) | WO2014014835A2 (sr) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SI1644336T1 (sl) | 2003-06-06 | 2011-06-30 | Fibrogen Inc | Heteroarilne spojine, ki vsebujejo duĺ ik in njihova uporaba pri zviĺ anju endogenega eritropoetina |
EP2370422B1 (en) | 2008-11-14 | 2019-06-05 | Fibrogen, Inc. | Thiochromene derivatives as hif hydroxylase inhibitors |
US8921389B2 (en) | 2011-02-02 | 2014-12-30 | Fibrogen, Inc. | Naphthyridine derivatives as inhibitors of hypoxia inducible factor (HIF) hydroxylase |
IN2015KN00262A (sr) | 2012-07-16 | 2015-06-12 | Fibrogen Inc | |
US8883823B2 (en) | 2012-07-16 | 2014-11-11 | Fibrogen, Inc. | Crystalline forms of a prolyl hydroxylase inhibitor |
DK2872487T3 (en) | 2012-07-16 | 2017-06-06 | Fibrogen Inc | PROCEDURE FOR THE PREPARATION OF ISOQUINOL COMPOUNDS |
PL3003284T3 (pl) | 2013-06-06 | 2020-08-10 | Fibrogen, Inc. | Formulacje farmaceutyczne inhibitora 5 hydroksylazy hif |
CN103694172A (zh) * | 2013-12-26 | 2014-04-02 | 辽宁亿灵科创生物医药科技有限公司 | 含氮杂芳基化合物的衍生物 |
WO2016045125A1 (en) | 2014-09-28 | 2016-03-31 | Merck Sharp & Dohme Corp. | Inhibitors of hif prolyl hydroxylase |
CN104892509B (zh) * | 2015-06-04 | 2018-03-09 | 苏州明锐医药科技有限公司 | 诺得司他的制备方法 |
CN106916105A (zh) * | 2015-12-28 | 2017-07-04 | 徐州万邦金桥制药有限公司 | 一种纯化可博美的方法 |
WO2017143131A1 (en) * | 2016-02-19 | 2017-08-24 | Cornell University | Hif-stabilization and prevention of hyperoxia-induced neonatal lung disease |
CN106187888A (zh) * | 2016-07-18 | 2016-12-07 | 江苏德源药业股份有限公司 | Fg‑4592单晶及其制备方法 |
CN108017583B (zh) * | 2016-11-01 | 2021-04-06 | 徐州万邦金桥制药有限公司 | 一种可博美的制备方法 |
CN107382986B (zh) * | 2017-08-02 | 2022-09-20 | 江苏艾立康医药科技有限公司 | 4-羟基-1-甲基异喹啉衍生物及其在增加内源性促红细胞生成素中的用途 |
WO2019030711A1 (en) * | 2017-08-11 | 2019-02-14 | Dr. Reddy’S Laboratories Limited | POLYMORPHS AND CO-CRYSTALS OF ROXADUSTAT |
WO2019042485A1 (en) | 2017-08-30 | 2019-03-07 | Zentiva, K.S. | FORMS IN THE STRONG STATE OF ROXADUSTAT |
CN111065625A (zh) * | 2017-09-04 | 2020-04-24 | 桑多斯股份公司 | 口服可利用的hif脯氨酰羟化酶抑制剂的共晶 |
CN112166105B (zh) | 2018-06-05 | 2022-03-04 | 沈阳化工大学 | 一种三氟乙基硫醚(亚砜)取代苯类化合物及其用途 |
CN111320583A (zh) * | 2018-12-14 | 2020-06-23 | 广东东阳光药业有限公司 | 诺德司他新晶型及其制备方法 |
CN109369525A (zh) * | 2018-12-29 | 2019-02-22 | 安礼特(上海)医药科技有限公司 | 罗沙司它的新晶型及其制备方法 |
WO2020217190A1 (en) * | 2019-04-26 | 2020-10-29 | Dr. Reddy’S Laboratories Limited | Process for the purification of roxadustat |
CN112679428A (zh) * | 2019-10-17 | 2021-04-20 | 罗欣药业(上海)有限公司 | 罗沙司他新晶型及其制备方法 |
JP2022553706A (ja) * | 2019-10-22 | 2022-12-26 | ▲蘇▼州科睿思制▲葯▼有限公司 | 低酸素誘導因子-プロリルヒドロキシラーゼ阻害剤の結晶形 |
CN110721185B (zh) * | 2019-11-13 | 2022-04-12 | 南京市儿童医院 | 罗沙司他用于心肌保护的用途 |
EP4121009A4 (en) * | 2020-03-17 | 2024-04-17 | Zydus Lifesciences Ltd | FORMULATION COMPRISING HIF PROLYL HYDROXYLASE INHIBITORS |
CN111205224B (zh) * | 2020-04-22 | 2020-08-25 | 南京佰麦生物技术有限公司 | 一种罗沙司他水合物的晶型及其制备方法和应用 |
CN113754569A (zh) * | 2020-06-04 | 2021-12-07 | 四川国为制药有限公司 | 一种中间体化合物及其制备方法和用途 |
CN111533691A (zh) * | 2020-06-08 | 2020-08-14 | 重庆三圣实业股份有限公司 | 一种罗沙司他的制备方法 |
CN114057643B (zh) * | 2020-08-04 | 2023-02-28 | 成都苑东生物制药股份有限公司 | 一种罗沙司他共晶及其制备方法 |
CN112500344B (zh) * | 2020-11-18 | 2022-07-01 | 江苏豪森药业集团有限公司 | 罗沙司他晶型及其制备方法 |
CN112194624A (zh) * | 2020-11-18 | 2021-01-08 | 江苏豪森药业集团有限公司 | 一种异喹啉类化合物的晶型及其制备方法 |
CN113956200A (zh) * | 2021-12-16 | 2022-01-21 | 南京威凯尔生物医药科技有限公司 | 一种粒径控制的罗沙司他原料药的结晶工艺 |
Family Cites Families (77)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4036964A (en) | 1973-10-11 | 1977-07-19 | Beecham Group Limited | Isocarbostyril-3-carboxylic acid derivatives for the prophylaxis of asthma, hayfever and rhinitis |
US3989704A (en) | 1973-10-30 | 1976-11-02 | Sandoz, Inc. | 3-Substituted-4-aryl isoquinolines |
DE2818423A1 (de) | 1978-04-27 | 1979-11-08 | Hoechst Ag | Neue isochinolinderivate und verfahren zu ihrer herstellung |
DE3233424A1 (de) | 1982-09-09 | 1984-03-15 | Hoechst Ag, 6230 Frankfurt | Isochinolinderivate, verfahren zu ihrer herstellung, pharmazeutische praeparate auf basis dieser verbindungen und ihre verwendung |
US4558006A (en) | 1983-02-04 | 1985-12-10 | Kirin-Amgen, Inc. | A.T.C.C. HB8209 and its monoclonal antibody to erythropoietin |
US4559403A (en) | 1983-05-19 | 1985-12-17 | Hoffmann-La Roche Inc. | Substituted isoquinolines |
US4584379A (en) | 1985-01-22 | 1986-04-22 | Merrell Dow Pharmaceuticals Inc. | Isoquinoline thromboxane synthetase inhibitors |
US4667016A (en) | 1985-06-20 | 1987-05-19 | Kirin-Amgen, Inc. | Erythropoietin purification |
US4822800A (en) | 1986-06-09 | 1989-04-18 | Ortho Pharmaceutical Corporation | Isoquinolinol compounds having cardiotonic and phosphodiesterase fraction III inhibiting properties and/or renal vasodilating properties |
US4966906A (en) | 1987-11-27 | 1990-10-30 | Hoechst-Roussel Pharmaceuticals Inc. | 1-aryl-3-isoquinolinecarboxamides |
US4952588A (en) | 1987-11-27 | 1990-08-28 | Hoechst-Roussel Pharmaceuticals Inc. | 1-aryl-3-quinoline-and 1-aryl-3-isoquinoline-carboxamides |
ATE149485T1 (de) | 1993-11-02 | 1997-03-15 | Hoechst Ag | Substituierte heterocyclische carbonsäureamidester, ihre herstellung und ihre verwendung als arzneimittel |
ES2101421T3 (es) | 1993-11-02 | 1997-07-01 | Hoechst Ag | Amidas de acidos carboxilicos heterociclicos sustituidos, su preparacion y su utilizacion como medicamentos. |
NZ270267A (en) | 1993-12-30 | 1997-03-24 | Hoechst Ag | 3-hydroxypyridin-2yl (and -quinolin-2-yl) carboxamide derivatives and pharmaceutical compositions |
AU4515696A (en) | 1994-12-12 | 1996-07-03 | Merck & Co., Inc. | Substituted 2-aminopyridines as inhibitors of nitric oxide synthase |
IL135495A (en) | 1995-09-28 | 2002-12-01 | Hoechst Ag | Intermediate compounds for the preparation of quinoline-converted amines - 2 - carboxylic acid |
CA2272565A1 (en) | 1996-11-27 | 1998-06-04 | Du Pont Pharmaceuticals Company | Integrin receptor antagonists |
DE19746287A1 (de) | 1997-10-20 | 1999-04-22 | Hoechst Marion Roussel De Gmbh | Substituierte Isochinolin-2-Carbonsäureamide, ihre Herstellung und ihre Verwendung als Arzneimittel |
FR2779963A1 (fr) | 1998-06-22 | 1999-12-24 | Centre Nat Rech Scient | Utilisation d'un compose possedant une affinite pour le recepteur mitochondrial des benzodiazepines en therapie du cancer |
IT1302677B1 (it) | 1998-10-15 | 2000-09-29 | Zambon Spa | Derivati benzazinici inibitori della fosfodiesterasi 4 |
WO2000064877A1 (en) | 1999-04-26 | 2000-11-02 | Neurogen Corporation | 2-aminoquinolinecarboxamides: neurokinin receptor ligands |
IT1315220B1 (it) * | 1999-12-13 | 2003-02-03 | Ipm Ind Plastica Monregalese | Telone di foglia pluristrato di materia plastica per pacciamature e/ocome barriera di contenimento di sostanze di trattamento in |
IT1320162B1 (it) | 2000-02-09 | 2003-11-18 | Rotta Research Lab | Derivati della tirosina ad attivita' anti leucotrienica, procedimentoper la loro preparazione e loro uso farmaceutico. |
FI20002044A0 (fi) | 2000-09-15 | 2000-09-15 | Orion Yhtymae Oyj | Comt-entsyymiä estäviä naftaleenijohdannaisia |
DE10110750A1 (de) | 2001-03-07 | 2002-09-12 | Bayer Ag | Neuartige Aminodicarbonsäurederivate mit pharmazeutischen Eigenschaften |
US6855510B2 (en) | 2001-03-20 | 2005-02-15 | Dana Farber Cancer Institute, Inc. | Pharmaceuticals and methods for treating hypoxia and screening methods therefor |
AU2002241154A1 (en) | 2001-03-21 | 2002-10-03 | Isis Innovation Ltd. | Assays, methods and means relating to hypoxia inducible factor (hif) hydroxylase |
JP2005505507A (ja) | 2001-06-13 | 2005-02-24 | ジーンソフト ファーマシューティカルズ インコーポレイテッド | 抗感染活性を有するイソキノリン化合物 |
US6716866B2 (en) | 2001-06-13 | 2004-04-06 | Genesoft Pharmaceuticals, Inc. | Aryl-benzimidazole compounds having antiinfective activity |
US6762318B2 (en) | 2001-12-03 | 2004-07-13 | Novo Nordisk A/S | Glucagon antagonists |
JP2005524612A (ja) | 2001-12-06 | 2005-08-18 | ファイブローゲン、インコーポレーテッド | 内因性エリスロポエチン(epo)を増加させる方法 |
US8318703B2 (en) | 2001-12-06 | 2012-11-27 | Fibrogen, Inc. | Methods for improving kidney function |
US7618940B2 (en) | 2002-12-06 | 2009-11-17 | Fibrogen, Inc. | Fat regulation |
US8124582B2 (en) | 2002-12-06 | 2012-02-28 | Fibrogen, Inc. | Treatment of diabetes |
EP1574215B1 (en) | 2002-12-16 | 2015-07-15 | Kissei Pharmaceutical Co., Ltd. | Solid drug for oral use |
US8614204B2 (en) | 2003-06-06 | 2013-12-24 | Fibrogen, Inc. | Enhanced erythropoiesis and iron metabolism |
US20060251638A1 (en) | 2003-06-06 | 2006-11-09 | Volkmar Guenzler-Pukall | Cytoprotection through the use of hif hydroxylase inhibitors |
SI1644336T1 (sl) | 2003-06-06 | 2011-06-30 | Fibrogen Inc | Heteroarilne spojine, ki vsebujejo duĺ ik in njihova uporaba pri zviĺ anju endogenega eritropoetina |
US20060173046A1 (en) | 2003-07-15 | 2006-08-03 | Bell Ian M | Hydroxypyridine cgrp receptor antagonists |
US20070042937A1 (en) | 2003-08-01 | 2007-02-22 | Fibrogen, Inc. | Inhibitors of 2-oxoglutarate dioxygenase as gamma globin inducers |
JP2007501844A (ja) | 2003-08-08 | 2007-02-01 | トランス テック ファーマ,インコーポレイテッド | アリール及びヘテロアリール化合物、組成物並びに使用方法 |
US7208601B2 (en) | 2003-08-08 | 2007-04-24 | Mjalli Adnan M M | Aryl and heteroaryl compounds, compositions, and methods of use |
JP4789264B2 (ja) | 2004-03-16 | 2011-10-12 | 旭化成ファーマ株式会社 | ファスジル含有製剤及びその安定性を改善する方法 |
JP2008500834A (ja) | 2004-05-28 | 2008-01-17 | ファイブローゲン、インコーポレーテッド | Hifプロリルヒドロキシラーゼ活性アッセイ |
GB2421013B (en) | 2004-12-10 | 2007-07-11 | Amcor Flexibles Europe As | Packaging with an openable top wall |
JP4792048B2 (ja) | 2005-03-02 | 2011-10-12 | ファイブロゲン インコーポレイティッド | チエノピリジン化合物およびその使用方法 |
AU2006254897A1 (en) | 2005-06-06 | 2006-12-14 | Fibrogen, Inc. | Improved treatment for anemia using a HIF-alpha stabilising agent |
US8530404B2 (en) * | 2005-06-15 | 2013-09-10 | Fibrogen, Inc. | Compounds and methods for treatment of cancer |
UA97349C2 (uk) | 2005-09-08 | 2012-02-10 | Х. Луннбэк А/С | Стійкі тверді склади сертиндолу |
EP2476669A1 (en) | 2006-01-27 | 2012-07-18 | Fibrogen, Inc. | Cyanoisoquinoline compounds and methods of use thereof |
WO2007097929A1 (en) | 2006-02-16 | 2007-08-30 | Fibrogen, Inc. | Compounds and methods for treatment of stroke |
KR101084635B1 (ko) | 2006-04-04 | 2011-11-18 | 피브로겐, 인크. | Hif 조절제로서 피롤로- 및 티아졸로-피리딘 화합물 |
WO2007141743A2 (en) | 2006-06-06 | 2007-12-13 | Ranbaxy Laboratories Limited | A tablet dosage form comprising cetirizine and pseudoephedrine |
US7713986B2 (en) | 2006-06-15 | 2010-05-11 | Fibrogen, Inc. | Compounds and methods for treatment of chemotherapy-induced anemia |
US20070293575A1 (en) | 2006-06-15 | 2007-12-20 | Fibrogen, Inc. | Compounds and methods for treatment of cancer-related anemia |
JP5683058B2 (ja) | 2007-04-27 | 2015-03-11 | ニプロ株式会社 | 経口固形製剤及びその製造方法 |
DK2209501T3 (da) | 2007-10-12 | 2012-02-27 | Astrazeneca Ab | Zibotentan-sammensætning, der indeholder mannitol og mikrokrystallinsk cellulose |
US8269008B2 (en) | 2007-12-03 | 2012-09-18 | Fibrogen, Inc. | Oxazolopyridine and isoxazolopyridine derivatives for use in the treatment of HIF-mediated conditions |
WO2009089547A1 (en) | 2008-01-11 | 2009-07-16 | Fibrogen, Inc. | Isothiazole-pyridine derivatives as modulators of hif (hypoxia inducible factor) activity |
WO2009100250A1 (en) | 2008-02-05 | 2009-08-13 | Fibrogen, Inc. | Chromene derivatives and use thereof as hif hydroxylase activity inhibitors |
CN102264740B (zh) | 2008-08-20 | 2014-10-15 | 菲布罗根有限公司 | 一种吡咯[1,2-b]哒嗪衍生物及其作为hif调节剂的用途 |
EP2370422B1 (en) | 2008-11-14 | 2019-06-05 | Fibrogen, Inc. | Thiochromene derivatives as hif hydroxylase inhibitors |
JP5479949B2 (ja) | 2009-04-08 | 2014-04-23 | 株式会社東芝 | 測定装置、測定方法、及び二酸化炭素回収システム |
JP2010248106A (ja) | 2009-04-14 | 2010-11-04 | Dainippon Sumitomo Pharma Co Ltd | フィルムコーティング錠 |
JP2012176899A (ja) | 2009-05-19 | 2012-09-13 | Mitsubishi Tanabe Pharma Corp | 2−(1−ピペラジニル)−5−メチルベンゼンスルホン酸誘導体を含む注射用水溶液 |
US8339523B2 (en) | 2010-05-18 | 2012-12-25 | Kabushiki Kaisha Toshiba | Television apparatus and electronic apparatus |
CN101880914B (zh) | 2010-05-25 | 2012-09-12 | 中国科学院微电子研究所 | 利用等离子体浸没离子注入制备黑硅的方法 |
CN103429239A (zh) | 2011-01-13 | 2013-12-04 | 菲布罗根有限公司 | 增加网织红细胞血红蛋白含量的方法 |
US8921389B2 (en) | 2011-02-02 | 2014-12-30 | Fibrogen, Inc. | Naphthyridine derivatives as inhibitors of hypoxia inducible factor (HIF) hydroxylase |
CN104024227B (zh) * | 2011-07-22 | 2015-12-02 | 北京贝美拓新药研发有限公司 | 抑制脯氨酸羟化酶活性的化合物的晶型及其应用 |
US20140309256A1 (en) | 2011-11-09 | 2014-10-16 | Fibrogen, Inc. | Therapeutic Method |
SG11201405574UA (en) | 2012-03-09 | 2014-10-30 | Fibrogen Inc | 4 -hydroxy- isoquinoline compounds as hif hydroxylase inhibitors |
US8883823B2 (en) | 2012-07-16 | 2014-11-11 | Fibrogen, Inc. | Crystalline forms of a prolyl hydroxylase inhibitor |
IN2015KN00262A (sr) | 2012-07-16 | 2015-06-12 | Fibrogen Inc | |
DK2872487T3 (en) | 2012-07-16 | 2017-06-06 | Fibrogen Inc | PROCEDURE FOR THE PREPARATION OF ISOQUINOL COMPOUNDS |
TWI685487B (zh) | 2013-01-24 | 2020-02-21 | 美商費比羅根公司 | {[1-氰基-5-(4-氯苯氧基)-4-羥基-異喹啉-3-羰基]-胺基}-乙酸之晶形 |
PL3003284T3 (pl) | 2013-06-06 | 2020-08-10 | Fibrogen, Inc. | Formulacje farmaceutyczne inhibitora 5 hydroksylazy hif |
-
2013
- 2013-07-15 IN IN262KON2015 patent/IN2015KN00262A/en unknown
- 2013-07-15 CN CN201310302481.7A patent/CN103539735B/zh active Active
- 2013-07-15 PL PL13740185T patent/PL2872488T3/pl unknown
- 2013-07-15 HU HUE13740185A patent/HUE041458T2/hu unknown
- 2013-07-15 HR HRP20220182TT patent/HRP20220182T1/hr unknown
- 2013-07-15 KR KR1020217034322A patent/KR20210130849A/ko not_active Application Discontinuation
- 2013-07-15 LT LTEP18189607.7T patent/LT3470397T/lt unknown
- 2013-07-15 CN CN201710546191.5A patent/CN107501177B/zh active Active
- 2013-07-15 MX MX2015000504A patent/MX355428B/es active IP Right Grant
- 2013-07-15 AU AU2013290438A patent/AU2013290438C1/en active Active
- 2013-07-15 SG SG10202111314YA patent/SG10202111314YA/en unknown
- 2013-07-15 JP JP2015523160A patent/JP6491093B2/ja active Active
- 2013-07-15 US US13/942,443 patent/US9115085B2/en active Active
- 2013-07-15 CN CN201380037479.XA patent/CN104684897A/zh active Pending
- 2013-07-15 CN CN201710546354.XA patent/CN107382859B/zh active Active
- 2013-07-15 PT PT13740185T patent/PT2872488T/pt unknown
- 2013-07-15 SG SG11201500236SA patent/SG11201500236SA/en unknown
- 2013-07-15 KR KR1020207024326A patent/KR102318720B1/ko active IP Right Grant
- 2013-07-15 CN CN201810750543.3A patent/CN109369524A/zh active Pending
- 2013-07-15 DK DK13740185.7T patent/DK2872488T3/en active
- 2013-07-15 CN CN201710546619.6A patent/CN107382860A/zh active Pending
- 2013-07-15 RS RS20220121A patent/RS63122B1/sr unknown
- 2013-07-15 HU HUE18189607A patent/HUE057925T2/hu unknown
- 2013-07-15 KR KR1020157003613A patent/KR102149380B1/ko active IP Right Grant
- 2013-07-15 EP EP18189607.7A patent/EP3470397B1/en active Active
- 2013-07-15 SI SI201331143T patent/SI2872488T1/sl unknown
- 2013-07-15 ES ES18189607T patent/ES2905898T3/es active Active
- 2013-07-15 DK DK18189607.7T patent/DK3470397T3/da active
- 2013-07-15 CN CN202210791828.8A patent/CN115093370A/zh active Pending
- 2013-07-15 WO PCT/US2013/050539 patent/WO2014014835A2/en active Application Filing
- 2013-07-15 CN CN201710546643.XA patent/CN107540607A/zh active Pending
- 2013-07-15 MY MYPI2015000129A patent/MY182428A/en unknown
- 2013-07-15 PT PT181896077T patent/PT3470397T/pt unknown
- 2013-07-15 ES ES13740185.7T patent/ES2689430T3/es active Active
- 2013-07-15 PL PL18189607T patent/PL3470397T3/pl unknown
- 2013-07-15 LT LTEP13740185.7T patent/LT2872488T/lt unknown
- 2013-07-15 KR KR1020227041256A patent/KR20220164068A/ko not_active Application Discontinuation
- 2013-07-15 RS RS20181268A patent/RS57795B1/sr unknown
- 2013-07-15 NZ NZ704662A patent/NZ704662A/en unknown
- 2013-07-15 SI SI201331973T patent/SI3470397T1/sl unknown
- 2013-07-15 SG SG10201700873UA patent/SG10201700873UA/en unknown
- 2013-07-15 CN CN202111361393.5A patent/CN114409596A/zh active Pending
- 2013-07-15 EP EP13740185.7A patent/EP2872488B1/en not_active Revoked
- 2013-07-15 BR BR112015001101A patent/BR112015001101A2/pt not_active Application Discontinuation
- 2013-07-15 CA CA2879242A patent/CA2879242C/en active Active
- 2013-07-15 EP EP21212372.3A patent/EP4029854A1/en active Pending
-
2015
- 2015-01-11 IL IL236626A patent/IL236626B/en active IP Right Grant
- 2015-07-21 US US14/805,345 patent/US9617218B2/en active Active
-
2017
- 2017-03-17 US US15/462,688 patent/US10118897B2/en active Active
- 2017-10-20 JP JP2017203509A patent/JP2018009034A/ja active Pending
-
2018
- 2018-02-28 HK HK18102870.1A patent/HK1243409A1/zh unknown
- 2018-10-11 US US16/158,242 patent/US20190276408A1/en not_active Abandoned
- 2018-10-24 HR HRP20181751TT patent/HRP20181751T1/hr unknown
- 2018-10-31 CY CY181101128T patent/CY1120805T1/el unknown
-
2019
- 2019-12-16 US US16/716,433 patent/US20200115344A1/en not_active Abandoned
-
2022
- 2022-02-14 CY CY20221100127T patent/CY1125155T1/el unknown
- 2022-06-15 FR FR22C1030C patent/FR22C1030I1/fr active Active
- 2022-06-20 LT LTPA2022510C patent/LTPA2022510I1/lt unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IN2015KN00262A (sr) | ||
PH12016501122A1 (en) | Delayed release compositions of linaclotide | |
MX2015000962A (es) | COMPLEJO CRISTALINO DE 1-CIANO-2-(4-CICLOPROPIL-BENCIL)-4-(ß-D-GLU COPIRANOS-1-IL)-BENCENO, METODOS PARA SU PREPARACION Y SU USO PARA PREPARAR MEDICAMENTOS. | |
HUE049168T2 (hu) | L-aminosav elõállítására képes mikroorganizmus és eljárás L-aminosav elõállítására annak alkalmazásával | |
MX2014010433A (es) | Nueva forma cristalina de sulfato de sitagliptina. | |
IN2015KN00323A (sr) | ||
MX360048B (es) | Formas cristalinas de acido { [1-ciano-5-(4-clorofenoxi)-4-hidroxi -isoquinolin-3-carbonil]-amino}-acetico. | |
MX340983B (es) | Composiciones farmaceuticas y nutraceuticas de acido abscisico. | |
MX362858B (es) | Proceso para la preparacion de pemetrexed y sal de lisina del mismo. | |
IN2015DN00085A (sr) | ||
MX2013013436A (es) | Derivados de indol sustituidos para el tratamiento de transtornos inmunologicos. | |
IN2014KN02722A (sr) | ||
MX347541B (es) | Analogos de acido sialico. | |
MX367773B (es) | Forma salina sólida de la alfa-6-mpeg6-o-hidroxicodona como agonistas opioides y sus usos. | |
MX2014004210A (es) | Derivados de 2-oxo-piperidinilo. | |
WO2014083575A3 (en) | Improved process for the preparation of boceprevir intermediate | |
IN2013CH04314A (sr) | ||
WO2014076616A3 (en) | Formulations of 5-azacytidine | |
WO2014122671A3 (en) | Solid oral compositions of saxagliptin | |
MX351994B (es) | Formas cristalinas de [(s)-1-carbamoil-2-(feniil-pirimidin-2-il-am ino)-etil]-amida del acido 2-(2-metilamino-pirimidin-4-il)-1h-indo l-5-carboxilico. | |
WO2013046233A3 (en) | Process for the preparation of octreotide acetate | |
IN2015DN02660A (sr) | ||
IN2014DN10683A (sr) | ||
WO2013064326A3 (de) | Arjunolsäure zur erhöhung der sebumproduktion | |
IN2013MU02771A (sr) |