IT1320162B1 - Derivati della tirosina ad attivita' anti leucotrienica, procedimentoper la loro preparazione e loro uso farmaceutico. - Google Patents

Derivati della tirosina ad attivita' anti leucotrienica, procedimentoper la loro preparazione e loro uso farmaceutico.

Info

Publication number
IT1320162B1
IT1320162B1 IT2000TO000127A ITTO20000127A IT1320162B1 IT 1320162 B1 IT1320162 B1 IT 1320162B1 IT 2000TO000127 A IT2000TO000127 A IT 2000TO000127A IT TO20000127 A ITTO20000127 A IT TO20000127A IT 1320162 B1 IT1320162 B1 IT 1320162B1
Authority
IT
Italy
Prior art keywords
group
independently
fluoro
chloro
carbon atoms
Prior art date
Application number
IT2000TO000127A
Other languages
English (en)
Inventor
Francesco Makovec
Walter Peris
Lucio Rovati
Original Assignee
Rotta Research Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to IT2000TO000127A priority Critical patent/IT1320162B1/it
Application filed by Rotta Research Lab filed Critical Rotta Research Lab
Priority to DE60126745T priority patent/DE60126745T2/de
Priority to AU33742/01A priority patent/AU776214B2/en
Priority to AT01905744T priority patent/ATE354571T1/de
Priority to JP2001558442A priority patent/JP4817577B2/ja
Priority to ES01905744T priority patent/ES2282234T3/es
Priority to PCT/EP2001/001315 priority patent/WO2001058892A1/en
Priority to PT01905744T priority patent/PT1255749E/pt
Priority to EP01905744A priority patent/EP1255749B1/en
Priority to US10/203,424 priority patent/US6605722B2/en
Priority to CA002399451A priority patent/CA2399451C/en
Publication of ITTO20000127A1 publication Critical patent/ITTO20000127A1/it
Application granted granted Critical
Publication of IT1320162B1 publication Critical patent/IT1320162B1/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D215/14—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/18—Halogen atoms or nitro radicals
IT2000TO000127A 2000-02-09 2000-02-09 Derivati della tirosina ad attivita' anti leucotrienica, procedimentoper la loro preparazione e loro uso farmaceutico. IT1320162B1 (it)

Priority Applications (11)

Application Number Priority Date Filing Date Title
IT2000TO000127A IT1320162B1 (it) 2000-02-09 2000-02-09 Derivati della tirosina ad attivita' anti leucotrienica, procedimentoper la loro preparazione e loro uso farmaceutico.
AU33742/01A AU776214B2 (en) 2000-02-09 2001-02-07 Tyrosine derivatives with anti-leukotriene activity
AT01905744T ATE354571T1 (de) 2000-02-09 2001-02-07 Tyrosin derivate mit leukotriene antagonistischer wirkung
JP2001558442A JP4817577B2 (ja) 2000-02-09 2001-02-07 抗ロイコトリエン活性を持つチロシン誘導体
DE60126745T DE60126745T2 (de) 2000-02-09 2001-02-07 Tyrosin derivate mit leukotriene antagonistischer wirkung
ES01905744T ES2282234T3 (es) 2000-02-09 2001-02-07 Derivados de la tirosina con actividad anti-leucotrienos.
PCT/EP2001/001315 WO2001058892A1 (en) 2000-02-09 2001-02-07 Tyrosine derivatives with anti-leukotriene activity
PT01905744T PT1255749E (pt) 2000-02-09 2001-02-07 Derivados de tirosina com actividade anti-leucotrieno
EP01905744A EP1255749B1 (en) 2000-02-09 2001-02-07 Tyrosine derivatives with anti-leukotriene activity
US10/203,424 US6605722B2 (en) 2000-02-09 2001-02-07 Tyrosine derivatives with anti-leukotrienen activity
CA002399451A CA2399451C (en) 2000-02-09 2001-02-07 Tyrosine derivatives with anti-leukotriene activity

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT2000TO000127A IT1320162B1 (it) 2000-02-09 2000-02-09 Derivati della tirosina ad attivita' anti leucotrienica, procedimentoper la loro preparazione e loro uso farmaceutico.

Publications (2)

Publication Number Publication Date
ITTO20000127A1 ITTO20000127A1 (it) 2001-08-09
IT1320162B1 true IT1320162B1 (it) 2003-11-18

Family

ID=11457397

Family Applications (1)

Application Number Title Priority Date Filing Date
IT2000TO000127A IT1320162B1 (it) 2000-02-09 2000-02-09 Derivati della tirosina ad attivita' anti leucotrienica, procedimentoper la loro preparazione e loro uso farmaceutico.

Country Status (11)

Country Link
US (1) US6605722B2 (it)
EP (1) EP1255749B1 (it)
JP (1) JP4817577B2 (it)
AT (1) ATE354571T1 (it)
AU (1) AU776214B2 (it)
CA (1) CA2399451C (it)
DE (1) DE60126745T2 (it)
ES (1) ES2282234T3 (it)
IT (1) IT1320162B1 (it)
PT (1) PT1255749E (it)
WO (1) WO2001058892A1 (it)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001261654A (ja) * 2000-03-21 2001-09-26 Mitsui Chemicals Inc キノリン誘導体およびそれを有効成分として含有する核内レセプター作動薬
EP1558581A4 (en) * 2002-10-07 2007-07-25 Bristol Myers Squibb Co DERIVATIVES OF TRIAZOLONE AND TRIAZOLETHIONE
WO2004108681A1 (en) 2003-06-06 2004-12-16 Fibrogen, Inc. Nitrogen-containing heteroaryl compounds and their use in increasing endogenous erythropoietin
CN103382216B (zh) 2006-01-27 2016-04-20 菲布罗根有限公司 使低氧诱导因子（hif）稳定的氰基异喹啉化合物
WO2007115315A2 (en) 2006-04-04 2007-10-11 Fibrogen, Inc. Pyrrolo- and thiazolo-pyridine compounds as hif modulators
US7687705B2 (en) * 2006-04-10 2010-03-30 Alabama A&M University Institute Efficient thermoelectric device
EP2370422B1 (en) 2008-11-14 2019-06-05 Fibrogen, Inc. Thiochromene derivatives as hif hydroxylase inhibitors
JP6129217B2 (ja) 2012-03-09 2017-05-17 フィブロジェン インコーポレイテッド Ｈｉｆヒドロキシラーゼインヒビターとしての４−ヒドロキシ−イソキノリン化合物
US8883823B2 (en) 2012-07-16 2014-11-11 Fibrogen, Inc. Crystalline forms of a prolyl hydroxylase inhibitor
US9340511B2 (en) 2012-07-16 2016-05-17 Fibrogen, Inc. Process for making isoquinoline compounds
RS63122B1 (sr) 2012-07-16 2022-05-31 Fibrogen Inc Kristalni oblici inhibitora prolil hidroksilaze
TWI685487B (zh) 2013-01-24 2020-02-21 美商費比羅根公司 ｛［１-氰基-５-（４-氯苯氧基）-４-羥基-異喹啉-３-羰基］-胺基｝-乙酸之晶形
US10604520B2 (en) * 2016-09-07 2020-03-31 Pliant Therapeutics, Inc. N-acyl amino acid compounds and methods of use

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1261835A (en) 1984-08-20 1989-09-26 Masaaki Toda (fused) benz(thio)amides
GB8607294D0 (en) 1985-04-17 1986-04-30 Ici America Inc Heterocyclic amide derivatives
IL89713A0 (en) 1988-03-29 1989-09-28 Ciba Geigy Ag Novel alkanophenones
DK0480717T3 (da) 1990-10-12 1999-02-08 Merck Frosst Canada Inc Umættede hydroxyalkylquinolinsyrer som leukotrienantagonister
US5508408A (en) 1993-09-10 1996-04-16 Ciba-Geigy Corporation Quinoline compound
ES2103180B1 (es) * 1994-08-01 1998-04-01 Menarini Lab Fenilacetamidas con accion antagonista de los leucotrienos.
WO1996033181A1 (en) 1995-04-21 1996-10-24 Daiichi Pharmaceutical Co., Ltd. Ethynylthiazole derivative
DE19823722A1 (de) * 1998-05-27 1999-12-02 Merckle Gmbh Chinolinylmethoxyaryl-Verbindungen als duale Inhibitoren der Cyclooxygenase und 5-Lipoxygenase

Also Published As

Publication number Publication date
ITTO20000127A1 (it) 2001-08-09
JP2003522768A (ja) 2003-07-29
CA2399451A1 (en) 2001-08-16
EP1255749A1 (en) 2002-11-13
DE60126745T2 (de) 2007-10-31
WO2001058892A1 (en) 2001-08-16
DE60126745D1 (de) 2007-04-05
CA2399451C (en) 2009-09-22
JP4817577B2 (ja) 2011-11-16
ES2282234T3 (es) 2007-10-16
PT1255749E (pt) 2007-05-31
AU3374201A (en) 2001-08-20
EP1255749B1 (en) 2007-02-21
US20030087910A1 (en) 2003-05-08
ATE354571T1 (de) 2007-03-15
AU776214B2 (en) 2004-09-02
US6605722B2 (en) 2003-08-12

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