SG11201500236SA - Crystalline forms of the prolyl hydroxylase inhibitor [(4-hydroxy-1-methyl-7-phenoxy-isoquinoline-3-carbonyl)-amino]-acetic acid - Google Patents
Crystalline forms of the prolyl hydroxylase inhibitor [(4-hydroxy-1-methyl-7-phenoxy-isoquinoline-3-carbonyl)-amino]-acetic acidInfo
- Publication number
- SG11201500236SA SG11201500236SA SG11201500236SA SG11201500236SA SG11201500236SA SG 11201500236S A SG11201500236S A SG 11201500236SA SG 11201500236S A SG11201500236S A SG 11201500236SA SG 11201500236S A SG11201500236S A SG 11201500236SA SG 11201500236S A SG11201500236S A SG 11201500236SA
- Authority
- SG
- Singapore
- Prior art keywords
- isoquinoline
- phenoxy
- carbonyl
- hydroxy
- amino
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
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- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Vascular Medicine (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Dermatology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- AIDS & HIV (AREA)
- Emergency Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Toxicology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Psychiatry (AREA)
- Rheumatology (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261672191P | 2012-07-16 | 2012-07-16 | |
US201361768297P | 2013-02-22 | 2013-02-22 | |
US201361832566P | 2013-06-07 | 2013-06-07 | |
PCT/US2013/050539 WO2014014835A2 (en) | 2012-07-16 | 2013-07-15 | Crystalline forms of a prolyl hydroxylase inhibitor |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201500236SA true SG11201500236SA (en) | 2015-02-27 |
Family
ID=48857025
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG10201700873UA SG10201700873UA (en) | 2012-07-16 | 2013-07-15 | Crystalline forms of the prolyl hydroxylase inhibitor [(4-hydroxy-1-methyl-7-phenoxy-isoquinoline-3-carbonyl)-amino]-acetic acid |
SG10202111314YA SG10202111314YA (en) | 2012-07-16 | 2013-07-15 | Crystalline forms of the prolyl hydroxylase inhibitor [(4-hydroxy-1-methyl-7-phenoxy-isoquinoline-3-carbonyl)-amino]-acetic acid |
SG11201500236SA SG11201500236SA (en) | 2012-07-16 | 2013-07-15 | Crystalline forms of the prolyl hydroxylase inhibitor [(4-hydroxy-1-methyl-7-phenoxy-isoquinoline-3-carbonyl)-amino]-acetic acid |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG10201700873UA SG10201700873UA (en) | 2012-07-16 | 2013-07-15 | Crystalline forms of the prolyl hydroxylase inhibitor [(4-hydroxy-1-methyl-7-phenoxy-isoquinoline-3-carbonyl)-amino]-acetic acid |
SG10202111314YA SG10202111314YA (en) | 2012-07-16 | 2013-07-15 | Crystalline forms of the prolyl hydroxylase inhibitor [(4-hydroxy-1-methyl-7-phenoxy-isoquinoline-3-carbonyl)-amino]-acetic acid |
Country Status (27)
Country | Link |
---|---|
US (5) | US9115085B2 (en) |
EP (3) | EP2872488B1 (en) |
JP (2) | JP6491093B2 (en) |
KR (4) | KR20210130849A (en) |
CN (9) | CN109369524A (en) |
AU (1) | AU2013290438C1 (en) |
BR (1) | BR112015001101A2 (en) |
CA (1) | CA2879242C (en) |
CY (2) | CY1120805T1 (en) |
DK (2) | DK2872488T3 (en) |
ES (2) | ES2689430T3 (en) |
FR (1) | FR22C1030I2 (en) |
HK (1) | HK1243409A1 (en) |
HR (2) | HRP20220182T1 (en) |
HU (2) | HUE057925T2 (en) |
IL (1) | IL236626B (en) |
IN (1) | IN2015KN00262A (en) |
LT (3) | LT2872488T (en) |
MX (1) | MX355428B (en) |
MY (1) | MY182428A (en) |
NZ (1) | NZ704662A (en) |
PL (2) | PL3470397T3 (en) |
PT (2) | PT2872488T (en) |
RS (2) | RS57795B1 (en) |
SG (3) | SG10201700873UA (en) |
SI (2) | SI3470397T1 (en) |
WO (1) | WO2014014835A2 (en) |
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KR102145272B1 (en) | 2012-07-16 | 2020-08-18 | 피브로겐, 인크. | Process for making isoquinoline compounds |
US8883823B2 (en) | 2012-07-16 | 2014-11-11 | Fibrogen, Inc. | Crystalline forms of a prolyl hydroxylase inhibitor |
DK2872488T3 (en) | 2012-07-16 | 2018-10-29 | Fibrogen Inc | CRYSTALLINIC FORMS OF A PROLYL HYDROXYLASE INHIBITOR |
CN110448537A (en) | 2013-06-06 | 2019-11-15 | 菲布罗根有限公司 | The pharmaceutical preparation of HIF hydroxylase inhibitors |
CN103694172A (en) * | 2013-12-26 | 2014-04-02 | 辽宁亿灵科创生物医药科技有限公司 | Derivative of aza-aryl compound |
WO2016045125A1 (en) | 2014-09-28 | 2016-03-31 | Merck Sharp & Dohme Corp. | Inhibitors of hif prolyl hydroxylase |
CN104892509B (en) * | 2015-06-04 | 2018-03-09 | 苏州明锐医药科技有限公司 | Nuo get Si Ta preparation method |
CN106916105A (en) * | 2015-12-28 | 2017-07-04 | 徐州万邦金桥制药有限公司 | A kind of method that purifying can win U.S. |
WO2017143131A1 (en) * | 2016-02-19 | 2017-08-24 | Cornell University | Hif-stabilization and prevention of hyperoxia-induced neonatal lung disease |
CN106187888A (en) * | 2016-07-18 | 2016-12-07 | 江苏德源药业股份有限公司 | FG 4592 monocrystalline and preparation method thereof |
CN108017583B (en) * | 2016-11-01 | 2021-04-06 | 徐州万邦金桥制药有限公司 | Preparation method of kebomei |
CN107382986B (en) * | 2017-08-02 | 2022-09-20 | 江苏艾立康医药科技有限公司 | 4-hydroxy-1-methylisoquinoline derivatives and their use in increasing endogenous erythropoietin |
US11168057B2 (en) | 2017-08-11 | 2021-11-09 | Dr. Reddy's Laboratories Limited | Polymorphs and co-crystals of roxadustat |
WO2019042485A1 (en) | 2017-08-30 | 2019-03-07 | Zentiva, K.S. | Solid forms of roxadustat |
JP7144510B2 (en) * | 2017-09-04 | 2022-09-29 | サンド・アクチエンゲゼルシヤフト | Co-crystals of orally administrable HIF prolyl hydroxylase inhibitors |
CN111978226B (en) | 2018-06-05 | 2022-03-04 | 沈阳化工大学 | Trifluoroethyl sulfide (sulfoxide) substituted benzene compound and application thereof |
CN111320583A (en) * | 2018-12-14 | 2020-06-23 | 广东东阳光药业有限公司 | New crystal form of nodestat and preparation method thereof |
CN109369525A (en) * | 2018-12-29 | 2019-02-22 | 安礼特(上海)医药科技有限公司 | Its novel crystal forms and preparation method thereof of Luo Shasi |
WO2020217190A1 (en) * | 2019-04-26 | 2020-10-29 | Dr. Reddy’S Laboratories Limited | Process for the purification of roxadustat |
CN112679428A (en) * | 2019-10-17 | 2021-04-20 | 罗欣药业(上海)有限公司 | New crystal form of roxasistat and preparation method thereof |
CN114344301B (en) * | 2019-10-22 | 2023-06-23 | 苏州科睿思制药有限公司 | Crystal form of hypoxia inducible factor prolyl hydroxylase inhibitor |
CN110721185B (en) * | 2019-11-13 | 2022-04-12 | 南京市儿童医院 | Use of Rosxastat for myocardial protection |
CN112961107B (en) * | 2019-12-13 | 2024-06-25 | 罗欣药业(上海)有限公司 | Luo Shasi his crystal form and preparation method thereof |
US20230190731A1 (en) * | 2020-03-17 | 2023-06-22 | Zydus Lifesciences Limited | Formulation comprising hif prolyl hydroxylase inhibitors |
CN111205224B (en) * | 2020-04-22 | 2020-08-25 | 南京佰麦生物技术有限公司 | Crystal form of roxasistat hydrate, and preparation method and application thereof |
CN113754569B (en) * | 2020-06-04 | 2024-07-02 | 四川国为制药有限公司 | Intermediate compound and preparation method and application thereof |
CN111533691A (en) * | 2020-06-08 | 2020-08-14 | 重庆三圣实业股份有限公司 | Preparation method of Rosxastat |
CN114057643B (en) * | 2020-08-04 | 2023-02-28 | 成都苑东生物制药股份有限公司 | Rosemastat eutectic crystal and preparation method thereof |
CN112500344B (en) * | 2020-11-18 | 2022-07-01 | 江苏豪森药业集团有限公司 | Crystalline form of roxasistat and preparation method thereof |
CN112194624A (en) * | 2020-11-18 | 2021-01-08 | 江苏豪森药业集团有限公司 | Crystal form of isoquinoline compound and preparation method thereof |
CN115724796A (en) * | 2021-08-26 | 2023-03-03 | 成都苑东生物制药股份有限公司 | New crystal form of roxasistat and preparation method thereof |
CN113956200A (en) * | 2021-12-16 | 2022-01-21 | 南京威凯尔生物医药科技有限公司 | Crystallization process of roxasistat bulk drug with controlled particle size |
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